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Allergy, Th2 cells

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https://www.readbyqxmd.com/read/28392331/maternal-phthalate-exposure-promotes-allergic-airway-inflammation-over-two-generations-via-epigenetic-modifications
#1
Susanne Jahreis, Saskia Trump, Mario Bauer, Tobias Bauer, Loreen Thürmann, Ralph Feltens, Qi Wang, Lei Gu, Konrad Grützmann, Stefan Röder, Marco Averbeck, Dieter Weichenhan, Christoph Plass, Ulrich Sack, Michael Borte, Virginie Dubourg, Gerrit Schüürmann, Jan C Simon, Martin von Bergen, Jörg Hackermüller, Roland Eils, Irina Lehmann, Tobias Polte
BACKGROUND: Prenatal and early postnatal exposures to environmental factors are considered responsible for the increasing prevalence of allergic diseases. Although there is some evidence for allergy-promoting effects in children due to exposure to plasticizers like phthalates, findings of previous studies are inconsistent and lack mechanistic information. OBJECTIVE: We investigated the effect of maternal phthalate exposure on asthma development in the subsequent generations and their underlying mechanisms including epigenetic alterations...
April 6, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28390860/basophil-derived-interleukin-4-promotes-epicutaneous-antigen-sensitization-concomitant-with-the-development-of-food-allergy
#2
Maryam Hussain, Loïc Borcard, Kevin P Walsh, Maria Pena Rodriguez, Christoph Mueller, Brian S Kim, Masato Kubo, David Artis, Mario Noti
BACKGROUND: Exaggerated TSLP production and infiltration of basophils are associated with the pathogenesis of atopic dermatitis (AD), a recognized risk factor for the development of food allergies. While TSLP and basophils have been implicated to promote food-induced allergic disorders in response to epicutaneous sensitization, the mechanisms by which TSLP-elicited basophils guide the progression of allergic inflammation in the skin to distant mucosal sites such as the gastrointestinal tract are poorly understood...
April 5, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28380410/quercetin-exhibits-adjuvant-activity-by-enhancing-th2-immune-response-in-ovalbumin-immunized-mice
#3
Divya Singh, Himanshi Tanwar, Bindhya Jayashankar, Jyoti Sharma, Swetha Murthy, Sudipta Chanda, Shashi Bala Singh, Lilly Ganju
Quercetin, one of the most abundant of plant flavonoids, has been studied with a great deal of attention over the last several decades mainly for its properties in inflammation and allergy. In this study, we are reporting for the first time the in vivo immunostimulatory activity of quercetin in ovalbumin immunized Balb/c mice. Administration of quercetin (50mg/kg body weight) along with ovalbumin antigen showed increased ovalbumin specific serum IgG antibody titres in comparison to the control group (p<0...
April 2, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28368013/structure-and-antagonism-of-the-receptor-complex-mediated-by-human-tslp-in-allergy-and-asthma
#4
Kenneth Verstraete, Frank Peelman, Harald Braun, Juan Lopez, Dries Van Rompaey, Ann Dansercoer, Isabel Vandenberghe, Kris Pauwels, Jan Tavernier, Bart N Lambrecht, Hamida Hammad, Hans De Winter, Rudi Beyaert, Guy Lippens, Savvas N Savvides
The pro-inflammatory cytokine thymic stromal lymphopoietin (TSLP) is pivotal to the pathophysiology of widespread allergic diseases mediated by type 2 helper T cell (Th2) responses, including asthma and atopic dermatitis. The emergence of human TSLP as a clinical target against asthma calls for maximally harnessing its therapeutic potential via structural and mechanistic considerations. Here we employ an integrative experimental approach focusing on productive and antagonized TSLP complexes and free cytokine...
April 3, 2017: Nature Communications
https://www.readbyqxmd.com/read/28349869/modulation-of-regulatory-t-cells-by-intranasal-allergen-immunotherapy-in-an-experimental-rat-model-of-airway-allergy
#5
Saibal Moitra, Ankur Datta, Somnath Mondal, Iman Hazra, Sk Md Omar Faruk, Prasanta K Das, Anjan K Basu, Santanu K Tripathi, Swapna Chaudhuri
Allergic airway diseases such as asthma and allergic rhinitis are increasing in prevalence worldwide. The theory of an altered Th1/Th2 balance in allergic diathesis has recently been termed a "procrustean paradigm" as it failed to explain many preclinical findings. Regulatory T cells (Treg) have now been shown to be critical in T-cell homeostasis and in the maintenance of peripheral tolerance to allergens. Allergen specific immunotherapy (SIT) has been shown to induce regulatory T cells in allergic patients...
March 24, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28346719/reduced-th22-cell-proportion-and-prevention-of-atopic-dermatitis-in-infants-following-maternal-probiotic-supplementation
#6
Anne Dorthea Bjerkenes Rø, Melanie Rae Simpson, Torstein Baade Rø, Ola Storrø, Roar Johnsen, Vibeke Videm, Torbjørn Øien
In the randomized, controlled study Probiotics in the Prevention of Allergy among Children in Trondheim (ProPACT), maternal probiotic supplementation reduced the incidence of atopic dermatitis (AD) in the offspring. In the current study, we hypothesized that the effect was mediated by a shift in the T helper (Th) cells in the children. OBJECTIVE: To examine whether Th cell proportions were affected by maternal probiotic supplementation and thus could mediate the preventive effect of probiotics on AD...
March 27, 2017: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28339013/immunological-effects-of-occupational-exposure-to-lead-review
#7
Concettina Fenga, Silvia Gangemi, Valentina Di Salvatore, Luca Falzone, Massimo Libra
It is well-known that occupational and environmental exposure to several factors, including benzene, heavy metals, chemicals and mineral fibers, is associated with the risk of developing a great number of diseases. Numerous studies have been carried out in order to investigate the mechanisms of toxicity of these substances, with particular regard to the possible toxic effects on the immune system. However, little is known about the influence of heavy metals, such as lead, on the immune system in human populations...
May 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28297747/enterococcus-faecium-fc-k-derived-from-kimchi-is-a-probiotc-lactic-acid-bacteria-that-shows-anti-allergic-activity
#8
Man-Kwang Rho, Young-Eun Kim, Hyun-In Rho, Tae-Rahk Kim, Yoon-Bum Kim, Won-Kyung Sung, Taw-Woo Kim, Dae-Ok Kim, Hee Kang
A rise in the occurrence of allergic diseases is attributed to the dysregulated balance of type 1/type 2 immunity, where type 2 T helper (Th2) cells predominate over type 1 T helper (Th1) cells, leading to an abnormally increased production of IgE in response to unharmful antigens. Kimchi, a traditional Korean fermented food, is a rich source of beneficial lactic acid bacteria. In this study, we investigated the ability of Enterococcus faecium FC-K derived from kimchi to induce type I immunity in the presence of Th2 polarizing conditions in vitro and in vivo...
March 15, 2017: Journal of Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28277274/therapeutic-reversal-of-food-allergen-sensitivity-by-mature-retinoic-acid-differentiated-dendritic-cell-induction-of-lag3-cd49b-foxp3-regulatory-t%C3%A2-cells
#9
Wojciech Dawicki, Chunyan Li, Jennifer Town, Xiaobei Zhang, John R Gordon
BACKGROUND: Anaphylaxis is a life-threatening condition for which we have limited therapeutic options. Although specific immunotherapy for food allergies is becoming more effective, it is still laborious and carries substantial risk of adverse events. On the other hand, regulatory dendritic cell (DC) therapy is effective in mouse models of allergic disease and has been shown to work with TH2 cells from atopic asthmatic patients. OBJECTIVE: We assessed whether DC immunotherapy could reverse food allergen sensitivity in mouse models to provide proof of concept relating to their use in the clinic...
October 20, 2016: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28266165/il33-and-il1rl1-variants-are-associated-with-asthma-and-atopy-in-a-brazilian-population
#10
G A Queiroz, R S Costa, N M Alcantara-Neves, G Nunes de Oliveira Costa, M L Barreto, V L Carneiro, C A Figueiredo
Atopic asthma is a chronic inflammatory disease in airways resulting from genetic and environmental factors, characterized by production of the Th2 cytokines interleukin-4 (IL-4), interleukin-5 (IL-5) and interleukin-13 (IL-13). Interleukin-33 (IL-33) appears to be a potent inducer of Th2 immune response. This occurs when IL-33 binds and activates its receptor, the membrane ST2 (ST2L) in mast cells, dendritic cells, basophils, eosinophils, innate lymphoids and Th2 cells, leading to the release of these cytokines and intensifying allergic inflammation...
April 2017: International Journal of Immunogenetics
https://www.readbyqxmd.com/read/28250847/oral-administration-of-clostridium-butyricum-cgmcc0313-1-inhibits-%C3%AE-lactoglobulin-induced-intestinal-anaphylaxis-in-a-mouse-model-of-food-allergy
#11
Juan Zhang, Hui Su, Qiuhong Li, Haixia Wu, Mengyun Liu, Jianqiong Huang, Minghua Zeng, Yuejie Zheng, Xin Sun
BACKGROUND: Probiotic bacteria can induce immune regulation or immune tolerance in patients with allergic diseases, but the underlying mechanisms are still unclear. There has been a growing interest in the use of beneficial bacteria for allergic diseases recently. This study aimed at exploring whether Clostridium butyricum CGMCC0313-1 (C. butyricum) can reduce β-lactoglobulin(BLG)-induced intestinal anaphylaxis in a murine model of food allergy. METHODS: The preventive and therapeutic effects of oral C...
2017: Gut Pathogens
https://www.readbyqxmd.com/read/28240301/pplase-of-dermatophagoides-farinae-promotes-ovalbumin-induced-airway-allergy-by-modulating-the-functions-of-dendritic-cells-in-a-mouse-model
#12
Hui Wang, Lihua Mo, Xiaojun Xiao, Shu An, Xiaoyu Liu, Jinge Ba, Weifang Wu, Pixin Ran, Pingchang Yang, Zhigang Liu
Our previous studies revealed that many proteins in addition to the known allergens of D. farinae have not been fully characterized. We observed that Pplase did not respond to serum collected from patients sensitized to D. farinae. In a mouse model, Pplase significantly enhanced airway hyperresponsiveness (AHR) and Th2 responses induced by ovalbumin (OVA) compared with mice treated with OVA alone. Moreover, exposure to Pplase significantly increased the expression of IRF4, CD80, CD83, MHCII and TNF-α in DC2...
February 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28235772/frontline-science-shh-production-and-gli-signaling-is-activated-in-vivo-in-lung-enhancing-the-th2-response-during-a-murine-model-of-allergic-asthma
#13
Ariane S I Standing, Diana C Yánez, Rosie Ross, Tessa Crompton, Anna L Furmanski
The pathophysiology of allergic asthma is driven by Th2 immune responses after aeroallergen inhalation. The mechanisms that initiate, potentiate, and regulate airway allergy are incompletely characterized. We have shown that Hh signaling to T cells, via downstream Gli transcription factors, enhances T cell conversion to a Th2 phenotype. In this study, we showed for the first time, to our knowledge, that Gli-dependent transcription is activated in T cells in vivo during murine AAD, a model for the immunopathology of asthma, and that genetic repression of Gli signaling in T cells decreases the differentiation and recruitment of Th2 cells to the lung...
February 24, 2017: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/28231571/luminex-liquichip-system-for-the-evaluation-of-cytokine-levels-in-patients-with-contact-dermatitis-to-potassium-dichromate
#14
Lehavit Akerman, Tirza Klein, Moshe Israeli, Abigail Fraser, Eti Sagy, Igor Snast, Daniel Mimouni, Michael David, Akiva Trattner
BACKGROUND: Allergic contact dermatitis (ACD) is associated with increased production of cytokines. The patch test is the "gold-standard" diagnostic method, but it poses a risk of false results. OBJECTIVE: To evaluate a novel laboratory technique, the Luminex LiquiChip, which simultaneously measures blood levels of multiple cytokines, as a diagnostic tool in patients with chrome-induced ACD. METHODS: The study group included 20 patients with ACD and relevant patch test results for potassium dichromate and 19 patients with ACD for nickel or fragrance as control...
February 24, 2017: Dermatology: International Journal for Clinical and Investigative Dermatology
https://www.readbyqxmd.com/read/28216433/lifelong-memory-responses-perpetuate-humoral-th2-immunity-and-anaphylaxis-in-food-allergy
#15
Rodrigo Jiménez-Saiz, Derek K Chu, Talveer S Mandur, Tina D Walker, Melissa E Gordon, Roopali Chaudhary, Joshua Koenig, Sarah Saliba, Heather J Galipeau, Adam Utley, Irah L King, Kelvin Lee, Rachel Ettinger, Susan Waserman, Roland Kolbeck, Manel Jordana
BACKGROUND: A number of food allergies (e.g. fish, shellfish, nuts) are lifelong, without any disease-transforming therapies and unclear in their underlying immunology. Clinical manifestations of food allergy are largely mediated by IgE. Although persistent IgE titres have conventionally been attributed to long-lived IgE(+) plasma cells (PCs), this has not been directly and comprehensively tested. OBJECTIVE: To evaluate mechanisms underlying persistent IgE and allergic responses to food allergens...
February 16, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28199353/oral-administration-of-lactobacillus-paracasei-l9-attenuates-pm2-5-induced-enhancement-of-airway-hyperresponsiveness-and-allergic-airway-response-in-murine-model-of-asthma
#16
Xifan Wang, Yan Hui, Liang Zhao, Yanling Hao, Huiyuan Guo, Fazheng Ren
This study investigated allergy immunotherapy potential of Lactobacillus paracasei L9 to prevent or mitigate the particulate matter 2.5 (PM2.5) enhanced pre-existing asthma in mice. Firstly, we used a mouse model of asthma (a 21-day ovalbumin (OVA) sensitization and challenge model) followed by PM2.5 exposure twice on the same day of the last challenge. PM2.5 was collected from the urban area of Beijing and underwent analysis for metals and polycyclic aromatic hydrocarbon contents. The results showed that PM2...
2017: PloS One
https://www.readbyqxmd.com/read/28185161/the-skin-as-a-route-of-allergen-exposure-part-i-immune-components-and-mechanisms
#17
REVIEW
Anna R Smith, George Knaysi, Jeffrey M Wilson, Julia A Wisniewski
PURPOSE OF REVIEW: To highlight recent contributions in the literature that enhance our understanding of the cutaneous immune response to allergen. RECENT FINDINGS: Defects in skin barrier function in infancy set the stage for the development of atopic dermatitis (AD) and allergy. Both genetic and environmental factors can contribute to damage of the stratum corneum (SC), with activation of specific protease enzymes under high pH conditions playing a key role. Immune cells and mediators in the dermis and epidermis impair SC repair mechanisms and support allergy development...
January 2017: Current Allergy and Asthma Reports
https://www.readbyqxmd.com/read/28159873/the-role-of-pkc%C3%AE-in-cord-blood-t-cell-maturation-towards-th1-cytokine-profile-and-its-epigenetic-regulation-by-fish-oil
#18
Hani Harb, James Irvine, Manori Amarasekera, Charles S Hii, Dörthe A Kesper, Yuefang Ma, Nina D'Vaz, Harald Renz, Daniel P Potaczek, Susan L Prescott, Antonio Ferrante
While immunodeficiency of immaturity of the neonate has been considered important as the basis for unusual susceptibility to infection, it has also been recognized that the ability to progress from an immature Th2 cytokine predominance to a Th1 profile has relevance in determining whether children will develop allergy, providing an opportunity for epigenetic regulation through environmental pressures. However, this notion remains relatively unexplored. Here we present evidence that there are two major control points to explain the immunodeficiency in cord blood (CB) T-cells, a deficiency in interleukin-12 (IL-12) producing and IL-10 overproducing accessory cells, leading to a decreased interferon-γ (IFNγ) synthesis, and the other an intrinsic defect in T-cell protein kinase C zeta (PKCζ) expression...
February 3, 2017: Bioscience Reports
https://www.readbyqxmd.com/read/28142300/dose-dependent-immunomodulating-effects-of-endotoxin-in-allergic-airway-inflammation
#19
Sudhir Kumar, Atin Adhikari
How very high exposure levels to endotoxin in a farming environment provide protection against respiratory allergic symptoms and low-to-moderate levels of endotoxin in urban homes promote allergic response is unclear. Dose-specific bacterial endotoxin or LPS-induced tolerance mechanisms can affect lung inflammations, coupled with the Th2 immune responses. Here, we explored the effects of intranasal exposure of LPS at two different doses (based on occupational exposures during handling of agricultural wastes) in OVA-sensitized allergic wild type (WT) and TLR4-KO mice, particularly, with respect to Th2 cytokines and Tregs level...
January 1, 2017: Innate Immunity
https://www.readbyqxmd.com/read/28107533/improvement-of-therapeutic-efficacy-of-oral-immunotherapy-in-combination-with-regulatory-t-cell-inducer-kakkonto-in-a-murine-food-allergy-model
#20
Yuka Nagata, Takeshi Yamamoto, Michie Hayashi, Shusaku Hayashi, Makoto Kadowaki
Oral immunotherapy (OIT) has been considered a promising approach for food allergies (FAs). However, the current OIT strategy is limited in terms of the long-term efficacy and safety. We have previously demonstrated that kakkonto, a traditional Japanese herbal medicine, suppresses the occurrence of allergic symptoms in a murine model of ovalbumin (OVA)-induced FA, which is attributed to the induction of the Foxp3+ CD4+ regulatory T cells. In this study, we established an OIT model using the FA mice with already established allergic symptoms and determined whether kakkonto could improve the efficacy of OIT...
2017: PloS One
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