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https://www.readbyqxmd.com/read/28421200/detection-of-urine-metabolites-in-a-rat-model-of-chronic-fatigue-syndrome-before-and-after-exercise
#1
Changzhuan Shao, Yiming Ren, Zinan Wang, Chenzhe Kang, Hongke Jiang, Aiping Chi
Purpose. The aim of the present study was to elucidate the metabolic mechanisms associated with chronic fatigue syndrome (CFS) via an analysis of urine metabolites prior to and following exercise in a rat model. Methods. A rat model of CFS was established using restraint-stress, forced exercise, and crowded and noisy environments over a period of 4 weeks. Behavioral experiments were conducted in order to evaluate the model. Urine metabolites were analyzed via gas chromatography-mass spectrometry (GC-MS) in combination with multivariate statistical analysis before and after exercise...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28388873/changes-in-the-dna-methylation-and-hydroxymethylation-status-of-the-intercellular-adhesion-molecule-1-gene-promoter-in-thyrocytes-from-autoimmune-thyroiditis-patients
#2
Tingting Liu, Jie Sun, Zhaojun Wang, Wenqing Yang, Hao Zhang, Chenling Fan, Zhongyan Shan, Weiping Teng
BACKGROUND: The intercellular adhesion molecule 1 (ICAM1) gene is not expressed in normal thyroid tissue but was shown to be expressed in the thyroid tissue of autoimmune thyroiditis (AIT) patients. METHODS: This study aimed to explore whether the DNA methylation and hydroxymethylation status of the ICAM1 promoter are aberrantly altered in the thyroid cells of AIT patients and whether this change is associated with dysfunctional expression of ICAM1. A total of 35 AIT patients and 35 sex- and age-matched controls were studied...
April 7, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/28366738/the-heartbreak-of-depression-psycho-cardiac-coupling-in-myocardial-infarction
#3
REVIEW
John P Headrick, Jason N Peart, Boris P Budiono, David H K Shum, David L Neumann, Nicolas J C Stapelberg
Ample evidence identifies strong links between major depressive disorder (MDD) and both risk of ischemic or coronary heart disease (CHD) and resultant morbidity and mortality. The molecular mechanistic bases of these linkages are poorly defined. Systemic factors linked to MDD, including vascular dysfunction, atherosclerosis, obesity and diabetes, together with associated behavioral changes, all elevate CHD risk. Nonetheless, experimental evidence indicates the myocardium is also directly modified in depression, independently of these factors, impairing infarct tolerance and cardioprotection...
March 31, 2017: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/28334933/disrupted-in-schizophrenia-1is-essential-for-normal-hypothalamic-pituitary-interrenal-hpi-axis-function
#4
Helen Eachus, Charlotte Bright, Vincent T Cunliffe, Marysia Placzek, Jonathan D Wood, Penelope J Watt
Psychiatric disorders arise due to an interplay of genetic and environmental factors, including stress. Studies in rodents have shown that mutants for Disrupted-In-Schizophrenia-1 (DISC1), a well-accepted genetic risk factor for mental illness, display abnormal behaviours in response to stress, but the mechanisms through which DISC1 affects stress responses remain poorly understood. Using two lines of zebrafish homozygous mutant for disc1, we investigated behaviour and functioning of the hypothalamic-pituitary-interrenal (HPI) axis, the fish equivalent of the hypothalamic-pituitary-adrenal (HPA) axis...
March 1, 2017: Human Molecular Genetics
https://www.readbyqxmd.com/read/28319688/attenuated-dhea-and-dhea-s-response-to-acute-psychosocial-stress-in-individuals-with-depressive-disorders
#5
Xiaoling Jiang, Wen Zhong, Haiyan An, Mingyu Fu, Yuanyuan Chen, Zhenggang Zhang, Zhongju Xiao
BACKGROUND: In recent years, a relationship between depression and basal dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulfate (DHEA-S) levels has frequently been suggested, but responses of these adrenal steroids to psychosocial stress have not been examined in individuals with depressive disorders. In this study, we examined salivary DHEA, DHEA-S, and cortisol/DHEA response to the Trier Social Stress Test (TSST) in individuals with depressive disorders and in healthy controls to discover whether the responses of DHEA and DHEA-S to acute psychosocial stress could be a more sensitive marker of HPA dysfunction in depressive disorders...
March 16, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28292649/increased-methylation-of-glucocorticoid-receptor-gene-promoter-1f-in-peripheral-blood-of-patients-with-generalized-anxiety-disorder
#6
Wei Wang, Junqin Feng, Cui Ji, Xin Mu, Qingyan Ma, Yajuan Fan, Ce Chen, Chengge Gao, Xian-Cang Ma, Feng Zhu
Previous findings on the dysfunction of hypothalamic-pituitary-adrenal (HPA) axis in generalized anxiety disorder (GAD) are controversial, and the molecular mechanisms underlying such dysfunction remain unclear. We analyzed the methylation status of the NR3C1 1F promoter and the expression of glucocorticoid receptor-α isoform (GRα) in peripheral blood mononuclear cells (PMBCs), the basal cortisol level in serum, and a functional neuroendocrine marker for GR sensitivity in the PMBCs in 64 patients with current GAD and 85 healthy controls...
March 3, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/28275643/a-translational-approach-to-clinical-practice-via-stress-responsive-glucocorticoid-receptor-signaling
#7
COMMENT
Mario F Juruena, Bruno Agustini, Anthony J Cleare, Allan H Young
A recent article by Kwan and colleagues could elegantly demonstrate the necessary interaction between neuronal serotonin (5-HT) systems and the hypothalamic-pituitary-adrenal (HPA) axis through glucocorticoid receptors (GR), producing an adequate stress response, in this case, responding to hypoxia with an increase in hematopoietic stem and progenitor cells (HSPC). There is an intricate system connecting brain, body and mind and this exchange is only possible when all these systems-nervous, endocrine, and immune-have receptors on critical cells to receive information (via messenger molecules) from each of the other systems...
2017: Stem Cell Investigation
https://www.readbyqxmd.com/read/28161195/activation-of-atp-sensitive-potassium-channel-by-iptakalim-normalizes-stress-induced-hpa-axis-disorder-and-depressive-behaviour-by-alleviating-inflammation-and-oxidative-stress-in-mouse-hypothalamus
#8
Xiao-Jie Zhao, Zhan Zhao, Dan-Dan Yang, Lu-Lu Cao, Ling Zhang, Juan Ji, Jun Gu, Ji-Ye Huang, Xiu-Lan Sun
Stress-induced disturbance of the hypothalamic-pituitary-adrenal (HPA) axis is strongly implicated in incidence of mood disorders. A heightened neuroinflammatory response and oxidative stress play a fundamental role in the dysfunction of the HPA axis. We have previously demonstrated that iptakalim (Ipt), a new ATP-sensitive potassium (K-ATP) channel opener, could prevent oxidative injury and neuroinflammation against multiple stimuli-induced brain injury. The present study was to demonstrate the impacts of Ipt in stress-induced HPA axis disorder and depressive behavior...
February 1, 2017: Brain Research Bulletin
https://www.readbyqxmd.com/read/28159647/alcohol-stress-and-glucocorticoids-from-risk-to-dependence-and-relapse-in-alcohol-use-disorders
#9
REVIEW
Sara K Blaine, Rajita Sinha
In this review, we detail the clinical evidence supporting the role of psychological and physiological stress in instrumental motivation for alcohol consumption during the development of mild to moderate alcohol use disorders (AUDs) and in the compulsive, habitual alcohol consumption seen in severe, chronic, relapsing AUDs. Traditionally, the study of AUDs has focused on the direct and indirect effects of alcohol on striatal dopaminergic pathways and their role in the reinforcing effects of alcohol. However, growing evidence also suggests that alcohol directly stimulates the hypothalamic pituitary adrenal (HPA) axis and has effects on glucocorticoid receptors in extrahypothalamic, limbic forebrain, and medial Prefrontal Cortex (PFC) circuits, which contribute to the development of AUDs and their progression in severity, chronicity, and relapse risk...
February 1, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/28137660/effects-of-moderate-treadmill-exercise-and-fluoxetine-on-behavioural-and-cognitive-deficits-hypothalamic-pituitary-adrenal-axis-dysfunction-and-alternations-in-hippocampal-bdnf-and-mrna-expression-of-apoptosis-related-proteins-in-a-rat-model-of-post-traumatic
#10
Sakineh Shafia, Abbas Ali Vafaei, Seyed Afshin Samaei, Ahmad Reza Bandegi, Alireza Rafiei, Reza Valadan, Zahra Hosseini-Khah, Raziyeh Mohammadkhani, Ali Rashidy-Pour
Post-traumatic stress disorder (PTSD) is a condition that develops after an individual has experienced a major trauma. Currently, selective serotonin reuptake inhibitors (SSRIs) like fluoxetine are the first-line choice in PTSD drug treatment but their moderate response rates and side effects indicate an urgent need for the development of new treatment. Physical activity is known to improve symptoms of certain neuropsychiatric disorders. The present study investigated the effects of moderate treadmill exercise, the antidepressant fluoxetine and the combined treatment on behavioural deficits, and hypothalamic-pituitary-adrenal (HPA) axis dysfunction...
January 28, 2017: Neurobiology of Learning and Memory
https://www.readbyqxmd.com/read/28135239/hypothalamic-crfr1-is-essential-for-hpa-axis-regulation-following-chronic-stress
#11
Assaf Ramot, Zhiying Jiang, Jin-Bin Tian, Tali Nahum, Yael Kuperman, Nicholas Justice, Alon Chen
The hypothalamic-pituitary-adrenal axis is a pivotal component of an organism's response to stressful challenges, and dysfunction of this neuroendocrine axis is associated with a variety of physiological and psychological pathologies. We found that corticotropin-releasing factor type 1 receptor within the paraventricular nucleus of the hypothalamus is an important central component of hypothalamic-pituitary-adrenal axis regulation that prepares the organism for successive exposure to stressful stimuli.
March 2017: Nature Neuroscience
https://www.readbyqxmd.com/read/28122298/stress-vulnerability-in-male-youth-with-internet-gaming-disorder
#12
Michael Kaess, Peter Parzer, Laura Mehl, Luisa Weil, Esther Strittmatter, Franz Resch, Julian Koenig
Internet Gaming Disorder [IGD] was introduced as new behavioral addiction in DSM-5 Section 3. Vulnerability to stress is a potential predisposing factor for IGD. Given a lack of preexisting empirical data, the study investigated differences in the psychological and neurobiological response to acute stress in patients with IGD. 24 young men (mean age 18.38 years; range 13-25 years) fulfilling DSM-5 criteria for IGD and 25 matched controls underwent the Trier Social Stress Test [TSST]. Participants provided hair samples for the analysis of basal hypothalamic-pituitary-adrenal [HPA] axis activity and clinical interviews were conducted to assess psychopathology...
January 10, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28035585/effect-of-exercise-on-ovulation-a-systematic-review
#13
REVIEW
Osnat Hakimi, Luiz-Claudio Cameron
BACKGROUND: Infertility has been described as a devastating life crisis for couples, and has a particularly severe effect on women, in terms of anxiety and depression. Anovulation accounts for around 30% of female infertility, and while lifestyle factors such as physical activity are known to be important, the relationship between exercise and ovulation is multi-factorial and complex, and to date there are no clear recommendations concerning exercise regimes. OBJECTIVES: The objective of this review was to systematically assess the effect of physical activity on ovulation and to discuss the possible mechanisms by which exercise acts to modulate ovulation in reproductive-age women...
December 29, 2016: Sports Medicine
https://www.readbyqxmd.com/read/28024808/total-and-free-cortisol-responses-and-their-relation-to-outcomes-after-cardiopulmonary-bypass-in-infants
#14
Eric L Wald, Carl L Backer, Joseph A Dearani, Zhuo Li, William C Oliver, Sheri S Crow
BACKGROUND: Hypothalamic-pituitary-adrenal (HPA) axis dysfunction may be partially responsible for the hemodynamic instability experienced by infants after cardiopulmonary bypass (CPB). We report the full spectrum of the HPA response surrounding CPB for infant congenital cardiac surgery. METHODS: We enrolled 84 infants who received 1 mg/kg of dexamethasone before initiation of CPB. Total cortisol (TC), free cortisol (FC), adrenocorticotropic hormone (ACTH), and corticosteroid-binding globulin (CBG) were measured at 3 time points: immediately before CPB (TP1), on intensive care unit arrival (TP2), and at 24 hours after surgery (TP3)...
May 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28024274/heterogeneity-in-hpa-axis-dysregulation-and-serotonergic-vulnerability-to-depression
#15
Marie-Laure Ancelin, Jacqueline Scali, Joanna Norton, Karen Ritchie, Anne-Marie Dupuy, Isabelle Chaudieu, Joanne Ryan
Variability in the serotonin transporter (5-HTTLPR) gene can influence the risk of depression associated with adversity, as well as cortisol stress reactivity, although not consistently. No study has examined the impact of both a stressful environment and corticotropic-axis dysfunction on depression, as a function of 5-HTTLPR. This population-based study included 334 subjects aged 65 and older. Depression was measured at both diagnostic (major depression according to DSM-IV) and symptomatic (subthreshold depression) levels of caseness, in addition to 5-HTTLPR and rs25531 genotyping and diurnal cortisol measures...
December 5, 2016: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/27998231/hypothalamic-pituitary-axis-dysfunction-in-survivors-of-childhood-cns-tumors-importance-of-systematic-follow-up-and-early-endocrine-consultation
#16
Wassim Chemaitilly, Gregory T Armstrong, Amar Gajjar, Melissa M Hudson
The Oncology Grand Rounds series is designed to place original reports published in the Journal into clinical context. A case presentation is followed by a description of diagnostic and management challenges, a review of the relevant literature, and a summary of the authors' suggested management approaches. The goal of this series is to help readers better understand how to apply the results of key studies, including those published in Journal of Clinical Oncology, to patients seen in their own clinical practice...
December 20, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/27981187/the-microbiome-a-key-regulator-of-stress-and-neuroinflammation
#17
REVIEW
Kieran Rea, Timothy G Dinan, John F Cryan
There is a growing emphasis on the relationship between the complexity and diversity of the microorganisms that inhabit our gut (human gastrointestinal microbiota) and health/disease, including brain health and disorders of the central nervous system. The microbiota-gut-brain axis is a dynamic matrix of tissues and organs including the brain, glands, gut, immune cells and gastrointestinal microbiota that communicate in a complex multidirectional manner to maintain homeostasis. Changes in this environment can lead to a broad spectrum of physiological and behavioural effects including hypothalamic-pituitary-adrenal (HPA) axis activation, and altered activity of neurotransmitter systems and immune function...
October 2016: Neurobiology of Stress
https://www.readbyqxmd.com/read/27965624/ru486-mitigates-hippocampal-pathology-following-status-epilepticus
#18
Aynara C Wulsin, James P Herman, Steve C Danzer
Status epilepticus (SE) induces rapid hyper-activation of the hypothalamo-pituitary-adrenocortical (HPA) axis. HPA axis hyperactivity results in excess exposure to high levels of circulating glucocorticoids, which are associated with neurotoxicity and depression-like behavior. These observations have led to the hypothesis that HPA axis dysfunction may exacerbate SE-induced brain injury. To test this hypothesis, we used the mouse pilocarpine model of epilepsy to determine whether use of the glucocorticoid receptor antagonist RU486 can attenuate hippocampal pathology following SE...
2016: Frontiers in Neurology
https://www.readbyqxmd.com/read/27930953/adolescent-binge-alcohol-exposure-increases-risk-assessment-behaviors-in-male-wistar-rats-after-exposure-to-an-acute-psychological-stressor-in-adulthood
#19
Audrey Torcaso, AnnaDorothea Asimes, Margaret Meagher, Toni R Pak
Teenage binge drinking is a common practice that has been shown to increase the risk for developing mood disorders in adulthood. The hypothalamo-pituitary-adrenal (HPA) axis is often dysfunctional in mood disorder patients, and animal models of adolescent binge alcohol exposure similarly show disordered HPA axis function, even after long periods of alcohol abstinence. Here, we sought to investigate the anxiety-like behavioral consequences of binge alcohol exposure in a Wistar rat model. Male rats were administered alcohol in a binge pattern during peri-puberty, and one month later, anxiety-like behaviors were measured using the elevated plus maze...
February 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/27922635/increased-plasma-levels-of-circulating-cell-free-mitochondrial-dna-in-suicide-attempters-associations-with-hpa-axis-hyperactivity
#20
D Lindqvist, J Fernström, C Grudet, L Ljunggren, L Träskman-Bendz, L Ohlsson, Å Westrin
Preclinical data suggest that chronic stress may cause cellular damage and mitochondrial dysfunction, potentially leading to the release of mitochondrial DNA (mtDNA) into the bloodstream. Major depressive disorder has been associated with an increased amount of mtDNA in leukocytes from saliva samples and blood; however, no previous studies have measured plasma levels of free-circulating mtDNA in a clinical psychiatric sample. In this study, free circulating mtDNA was quantified in plasma samples from 37 suicide attempters, who had undergone a dexamethasone suppression test (DST), and 37 healthy controls...
December 6, 2016: Translational Psychiatry
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