keyword
MENU ▼
Read by QxMD icon Read
search

Hpa dysfunction

keyword
https://www.readbyqxmd.com/read/27887997/a-role-for-leptin-regulated-neurocircuitry-in-subordination-stress
#1
REVIEW
Jonathan N Flak
The visible burrow system produces a distinct combination of psychological and metabolic stress on, primarily, subordinate individuals that results in pronounced physiologic and behavioral dysfunction. However, the mechanisms underlying the consequences of chronic subordination stress are largely unknown. The simplest mechanistic explanation is that adaptations within brain systems with overlapping functions of both psychological and metabolic control provide immediate benefits that result in lasting susceptibility to diseases, disorders, and increased mortality rates in subordinates...
November 22, 2016: Physiology & Behavior
https://www.readbyqxmd.com/read/27883963/hypothalamic-pituitary-adrenal-axis-activity-and-cognition-in-major-depression-the-role-of-remission-status
#2
Neus Salvat-Pujol, Javier Labad, Mikel Urretavizcaya, Aida de Arriba-Arnau, Cinto Segalàs, Eva Real, Alex Ferrer, José M Crespo, Susana Jiménez-Murcia, Carles Soriano-Mas, José M Menchón, Virginia Soria
OBJECTIVES: Neuropsychological deficits and hypothalamic-pituitary-adrenal (HPA) axis dysfunction have been described in major depressive disorder (MDD). We conducted an exploratory study to investigate the role of remission status in the relationship between HPA axis and cognition in MDD. METHODS: Ninety-seven MDD patients (44 remitted, 53 non-remitted) and 97 healthy controls (HC) were evaluated. We measured verbal and visual memory, working memory, processing speed, attention, and executive function...
November 10, 2016: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/27857954/heat-stress-gastrointestinal-permeability-and-interleukin-6-signaling-implications-for-exercise-performance-and-fatigue
#3
REVIEW
Nicole Vargas, Frank Marino
Exercise in heat stress exacerbates performance decrements compared to normothermic environments. It has been documented that the performance decrements are associated with reduced efferent drive from the central nervous system (CNS), however, specific factors that contribute to the decrements are not completely understood. During exertional heat stress, blood flow is preferentially distributed away from the intestinal area to supply the muscles and brain with oxygen. Consequently, the gastrointestinal barrier becomes increasingly permeable, resulting in the release of lipopolysaccharides (LPS, endotoxin) into the circulation...
April 2016: Temperature: Multidisciplinary Biomedical Journal
https://www.readbyqxmd.com/read/27845056/antidepressant-like-effects-of-yl-ipa08-a-potent-ligand-for-the-translocator-protein-18%C3%A2-kda-in-chronically-stressed-rats
#4
Li-Ming Zhang, Yu-Lu Wang, Yan-Qin Liu, Rui Xue, You-Zhi Zhang, Ri-Fang Yang, Yun-Feng Li
The present study aimed to examine the molecular and cellular mechanisms underlying the antidepressant-like effect of YL-IPA08, a novel TSPO ligand designed and synthesized at our institute. We firstly used the chronic unpredictable stress (CUS) procedure of rats, a well validated stress-related animal model of depression, to further determine the antidepressant-like of YL-IPA08. And we found that YL-IPA08 caused significant suppression of inhibiting of locomotor activity, reducing the sucrose preference and increasing the latency to eat induced by CUS...
November 11, 2016: Neuropharmacology
https://www.readbyqxmd.com/read/27843437/paraventricular-hypothalamic-mechanisms-of-chronic-stress-adaptation
#5
REVIEW
James P Herman, Jeffrey G Tasker
The hypothalamic paraventricular nucleus (PVN) is the primary driver of hypothalamo-pituitary-adrenocortical (HPA) responses. At least part of the role of the PVN is managing the demands of chronic stress exposure. With repeated exposure to stress, hypophysiotrophic corticotropin-releasing hormone (CRH) neurons of the PVN display a remarkable cellular, synaptic, and connectional plasticity that serves to maximize the ability of the HPA axis to maintain response vigor and flexibility. At the cellular level, chronic stress enhances the production of CRH and its co-secretagogue arginine vasopressin and rearranges neurotransmitter receptor expression so as to maximize cellular excitability...
2016: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/27830572/inflammation-associated-co-morbidity-between-depression-and-cardiovascular-disease
#6
Angelos Halaris
Morbidity and mortality of cardiovascular disease (CVD) is exceedingly high worldwide. Depressive illness is a serious psychiatric illness that afflicts a significant portion of the world population. Epidemiological studies have confirmed the high co-morbidity between these two disease entities. The co-morbidity is bidirectional and the mechanisms responsible for it are complex and multifaceted. In addition to genetic, biological systems, psychosocial, and behavioral factors that are involved include the central and autonomic nervous systems, the neuroendocrine, immune, and the vascular and hematologic systems...
November 10, 2016: Current Topics in Behavioral Neurosciences
https://www.readbyqxmd.com/read/27810935/disruption-of-glucagon-like-peptide-1-signaling-in-sim1-neurons-reduces-physiological-and-behavioral-reactivity-to-acute-and-chronic-stress
#7
Sriparna Ghosal, Amy E B Packard, Parinaz Mahbod, Jessica M McKlveen, Randy J Seeley, Brent Myers, Yvonne Ulrich-Lai, Eric P Smith, David A D'Alessio, James P Herman
Organismal stress initiates a tightly orchestrated set of responses involving complex physiological and neurocognitive systems. Here, we present evidence for glucagon-like peptide 1 (GLP-1) mediated paraventricular hypothalamic circuit coordinating the global stress response. The GLP-1 receptor (Glp1r) in mice was knocked down in neurons expressing single-minded 1 (Sim1), a transcription factor abundantly expressed in the paraventricular nucleus (PVN) of the hypothalamus. Mice with Sim1-mediated Glp1r knockdown had reduced hypothalamic-pituitary-adrenal (HPA) axis responses to both acute and chronic stress and were protected against weight loss associated with chronic stress...
November 3, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/27751733/the-link-between-aberrant-hypothalamic-pituitary-adrenal-axis-activity-during-development-and-the-emergence-of-aggression-animal-studies
#8
Sophie E Walker, Aurélie Papilloud, Damien Huzard, Carmen Sandi
Aggressive behavior is not uniform, including proactive and reactive forms of aggression. Aberrant functioning of the hypothalamic-pituitary-adrenal (HPA) axis is frequently associated with abnormal aggression. Here, we review the rodent literature in order to assess whether developmental abnormalities in the HPA axis can be causally linked with the emergence of abnormal aggression. We examine studies that involve genetic models and life challenges (e.g., early life stress, drug exposure) that course with developmental alterations in the HPA axis...
October 14, 2016: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/27697410/time-dependence-of-radiation-induced-hypothalamic-pituitary-axis-dysfunction-in-adults-treated-for-non-pituitary-intracranial-neoplasms
#9
N Taku, M Gurnell, N Burnet, R Jena
AIMS: Hypothalamic-pituitary axis (HPA) dysfunction is a sequela of cranial radiotherapy. The purpose of this study was to use endocrine data from existing publications to characterise the baseline endocrine status, the effects of radiotherapy on the HPA during the first follow-up year and the time dependence of radiation-induced HPA dysfunction in patients treated with radiotherapy for non-pituitary intracranial neoplasms. MATERIALS AND METHODS: A systematic search of databases was carried out for articles that reported the results of endocrine testing for patients aged 16 years and older who were treated with neurosurgery for non-pituitary intracranial neoplasms or radiotherapy for nasopharyngeal neoplasms...
September 30, 2016: Clinical Oncology: a Journal of the Royal College of Radiologists
https://www.readbyqxmd.com/read/27677093/hypothalamus-pituitary-adrenocortical-dysfunction-in-elderly-male-marathon-runners-feedback-sensitivity-stress-response-and-effects-on-verbal-memory
#10
Michael Deuschle, Ulrike Gotthardt, Ulrich Schweiger, Michael Dettling, Florian Holsboer, Isabella Heuser
Animal studies suggest that repeated episodes of elevated glucocorticoids lead to a dysregulation of the hypothalamus-pituitary-adrenal (HPA) system at a supra-pituitary level, and to impaired mnemonic function. We compared cognitive tests and both, feedback integrity and stress responsivity of the HPA system, between 11 elderly, male marathon runners - a model of repeated HPA system activation - and 10 sedentary controls. Marathon runners had significantly increased baseline, stress and post-stress ACTH, but not cortisol concentrations...
September 28, 2016: Neuroendocrinology
https://www.readbyqxmd.com/read/27641324/long-lasting-monoaminergic-and-behavioral-dysfunctions-in-a-mice-model-of-socio-environmental-stress-during-adolescence
#11
A P N de Lima, T M Sandini, T M Reis-Silva, C O Massoco
Adolescence is one of the critical periods of development and has great importance to health for an individual as an adult. Stressors or traumatic events during this period are associated with several psychiatric disorders as related to anxiety or depression and cognitive impairments, but whether negative experiences continue to hinder individuals as they age is not as well understood. We determined how stress during adolescence affects behavior and neurochemistry in adulthood. Using an unpredictable paradigm (2 stressors per day for 10days) in Balb/c mice, behavioral, hormonal, and neurochemical changes were identified 20days after the cessation of treatment...
September 15, 2016: Behavioural Brain Research
https://www.readbyqxmd.com/read/27638035/association-between-fkbp5-and-crhr1-genes-with-suicidal-behavior-a-systematic-review
#12
Eduardo De la Cruz-Cano
Suicide is one of the leading causes of death around the world with approximately one million suicides per year. An increasing number of neurobiological studies implicate HPA system dysfunction in suicide behavior, stimulating genetic research to focus on genes related to this system. This systematic review was focused on searching a correlation between FKBP5 and CRHR1 genes with suicidal behavior. Therefore, an electronic search strategy, using PubMed, EBSCO and Cochrane Library databases, was conducted from the inception of the studies into the databases to July 2016...
September 13, 2016: Behavioural Brain Research
https://www.readbyqxmd.com/read/27619171/further-evidence-of-hpa-axis-dysregulation-and-its-correlation-with-depression-in-autism-spectrum-disorders-data-from-girls
#13
Christopher F Sharpley, Vicki Bitsika, Nicholas M Andronicos, Linda L Agnew
To further describe Hypothalamus-Pituitary-Adrenal (HPA) axis activity in children with Autism Spectrum Disorder (ASD), the Diurnal Fluctuation (DF) and Cortisol Awakening Response (CAR) were investigated in a sample of 39 high functioning girls with ASD. Although group mean data conformed to the DF and CAR models, over half of the participants showed inverse CAR and over 14% had inverted DF cortisol concentrations. Examination of three potential sets of predictor factors (physiological, ASD-related, and mood) revealed that only self-reported Major Depressive Disorder was significantly associated with CAR status, and that the girls' concern about dying or suicide was the most powerful contributor to the variance in CAR status...
September 13, 2016: Physiology & Behavior
https://www.readbyqxmd.com/read/27618384/methylation-of-glucocorticoid-receptor-gene-promoter-modulates-morphine-dependence-and-accompanied-hypothalamus-pituitary-adrenal-axis-dysfunction
#14
Jie Zhu, Feng Zhu, Na Zhao, Xin Mu, Pingping Li, Wei Wang, Jian Liu, Xiancang Ma
Previous studies demonstrated that dysfunction of the hypothalamus-pituitary-adrenal (HPA) axis played an important role in morphine dependence. Nonetheless, the molecular mechanism underlying morphine-induced HPA axis dysfunction and morphine dependence remains unclear. In the current study, 5'-aza-2'-deoxycytidine (5-aza), an inhibitor of DNA methyltransferases (DNMTs), was used to examine the effects of glucocorticoid receptor (GR) promoter 17 methylation on chronic morphine-induced HPA axis dysfunction and behavioral changes in rats and the underlying mechanism...
September 12, 2016: Journal of Neuroscience Research
https://www.readbyqxmd.com/read/27535914/a-basal-forebrain-site-coordinates-the-modulation-of-endocrine-and-behavioral-stress-responses-via-divergent-neural-pathways
#15
Shane B Johnson, Eric B Emmons, Rachel M Anderson, Ryan M Glanz, Sara A Romig-Martin, Nandakumar S Narayanan, Ryan T LaLumiere, Jason J Radley
UNLABELLED: The bed nuclei of the stria terminalis (BST) are critically important for integrating stress-related signals between the limbic forebrain and hypothalamo-pituitary-adrenal (HPA) effector neurons in the paraventricular hypothalamus (PVH). Nevertheless, the circuitry underlying BST control over the stress axis and its role in depression-related behaviors has remained obscure. Utilizing optogenetic approaches in rats, we have identified a novel role for the anteroventral subdivision of BST in the coordinated inhibition of both HPA output and passive coping behaviors during acute inescapable (tail suspension, TS) stress...
August 17, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/27510168/the-caffeine-binding-adenosine-a2a-receptor-induces-age-like-hpa-axis-dysfunction-by-targeting-glucocorticoid-receptor-function
#16
Vânia L Batalha, Diana G Ferreira, Joana E Coelho, Jorge S Valadas, Rui Gomes, Mariana Temido-Ferreira, Tatiana Shmidt, Younis Baqi, Luc Buée, Christa E Müller, Malika Hamdane, Tiago F Outeiro, Michael Bader, Sebastiaan H Meijsing, Ghazaleh Sadri-Vakili, David Blum, Luísa V Lopes
Caffeine is associated with procognitive effects in humans by counteracting overactivation of the adenosine A2A receptor (A2AR), which is upregulated in the human forebrain of aged and Alzheimer's disease (AD) patients. We have previously shown that an anti-A2AR therapy reverts age-like memory deficits, by reestablishment of the hypothalamic-pituitary-adrenal (HPA) axis feedback and corticosterone circadian levels. These observations suggest that A2AR over-activation and glucocorticoid dysfunction are key events in age-related hippocampal deficits; but their direct connection has never been explored...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27479489/co-morbidity-of-ptsd-and-immune-system-dysfunction-opportunities-for-treatment
#17
REVIEW
Gretchen N Neigh, Fariya F Ali
Posttraumatic stress disorder (PTSD) is defined as a psychiatric disorder; however, PTSD co-occurs with multiple somatic manifestations. People living with PTSD commonly manifest dysregulations in the systems that regulate the stress response, including the hypothalamic-pituitary-adrenal (HPA) axis, and development of a pro-inflammatory state. Additionally, somatic autoimmune and inflammatory diseases and disorders have a high rate of co-morbidity with PTSD. Recognition and understanding of the compounding effect that these disease states can have on each other, evidenced from poorer treatment outcomes and accelerated disease progression in patients suffering from co-morbid PTSD and/or other autoimmune and inflammatory diseases, has the potential to lead to additional treatment opportunities...
August 2016: Current Opinion in Pharmacology
https://www.readbyqxmd.com/read/27460005/dopamine-agonist-therapy-induces-significant-recovery-of-hpa-axis-function-in-prolactinomas-independent-of-tumor-size-a-large-single-center-experience
#18
Christine G Yedinak, Isabelle Cetas, Alp Ozpinar, Shirley McCartney, Aclan Dogan, Maria Fleseriu
Our objective was to compare prevalence and rates of recovery of hypothalamic-pituitary-adrenal axis dysfunction in prolactinoma patients before and after dopamine agonist therapy with nonfunctioning pituitary adenoma patients pre-transsphenoidal and post-transsphenoidal surgery. We retrospectively compared hypothalamic-pituitary-adrenal axis function in patients with prolactinomas naïve to dopamine agonist therapy with a cohort of nonfunctioning pituitary adenoma patients matched for gender and tumor size by classification (n = 57; 30 male/27 female; 27 microadenoma/30 macroadenoma)...
October 2016: Endocrine
https://www.readbyqxmd.com/read/27438830/behavioral-abnormality-induced-by-enhanced-hypothalamo-pituitary-adrenocortical-axis-activity-under-dietary-zinc-deficiency-and-its-usefulness-as-a-model
#19
REVIEW
Atsushi Takeda, Haruna Tamano, Ryusuke Nishio, Taku Murakami
Dietary zinc deficiency increases glucocorticoid secretion from the adrenal cortex via enhanced hypothalamo-pituitary-adrenocortical (HPA) axis activity and induces neuropsychological symptoms, i.e., behavioral abnormality. Behavioral abnormality is due to the increase in glucocorticoid secretion rather than disturbance of brain zinc homeostasis, which occurs after the increase in glucocorticoid secretion. A major target of glucocorticoids is the hippocampus and their actions are often associated with disturbance of glutamatergic neurotransmission, which may be linked to behavioral abnormality, such as depressive symptoms and aggressive behavior under zinc deficiency...
2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27387895/male-specific-effects-of-lipopolysaccharide-on-glucocorticoid-receptor-nuclear-translocation-in-the-prefrontal-cortex-of-depressive-rats
#20
Zeljka Brkic, Zorica Petrovic, Dusanka Franic, Milos Mitic, Miroslav Adzic
RATIONALE: Inflammation plays a key role in the pathogenesis of major depressive disorder (MDD) for a subset of depressed individuals. One of the possible routes by which cytokines can induce depressive symptoms is by promoting the dysregulation of hypothalamic-pituitary-adrenal (HPA) axis via altering glucocorticoid receptor (GR) function. OBJECTIVES: We investigated the mechanisms that finely tune the GR functioning upon lipopolysaccharide (LPS), i.e., subcellular localization of the GR, the levels of its co-chaperones FK506 binding protein 52 (FKBP4) and FK506 binding protein 51 (FKBP5), the receptor phosphorylation status along with its upstream kinases, as well as mRNA levels of GR-regulated genes in the prefrontal cortex (PFC) of male and female Wistar rats...
September 2016: Psychopharmacology
keyword
keyword
69214
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"