Clara Chrétienneau, Leticia M Spindola, Florence Vorspan, Trine Vik Lagerberg, Cynthia Marie-Claire, Frank Bellivier, Stéphane Mouly, Jean-Louis Laplanche, Vanessa Bloch, Stéphanie Le Hellard, Romain Icick
Suicide attempts (SA) are prevalent in substance use disorders (SUD). Epigenetic mechanisms may play a pivotal role in the molecular mechanisms of environmental effects eliciting suicidal behaviour in this population. Hypothalamic-pituitary-adrenal axis (HPA), oxytocin and neurotrophin pathways have been consistently involved in SA, yet , their interplay with childhood adversity remains unclear, particularly in SUD. In 24 outpatients with SUDs, we examined the relation between three parental dysfunctional styles and history of SA with methylation of 32 genes from these pathways, eventually analysing 823 methylation sites...
April 2024: Addiction Biology