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https://www.readbyqxmd.com/read/28921462/bifidobacterium-pseudocatenulatum-cect-7765-ameliorates-neuroendocrine-alterations-associated-with-an-exaggerated-stress-response-and-anhedonia-in-obese-mice
#1
Ana Agusti, A Moya-Pérez, I Campillo, S Montserrat-de la Paz, V Cerrudo, A Perez-Villalba, Yolanda Sanz
Obesity, besides being a problem of metabolic dysfunction, constitutes a risk factor for psychological disorders. Experimental models of diet-induced obesity have revealed that obese animals are prone to anxious and depressive-like behaviors. The present study aimed to evaluate whether Bifidobacterium pseudocatenulatum CECT 7765 could reverse the neurobehavioral consequences of obesity in a high-fat diet (HFD) fed mouse model via regulation of the gut-brain axis. Adult male wild-type C57BL-6 mice were fed a standard diet or HFD, supplemented with either placebo or the bifidobacterial strain for 13 weeks...
September 18, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28918107/depression-evening-salivary-cortisol-and-inflammation-in-chronic-fatigue-syndrome-a-psychoneuroendocrinological-structural-regression-model
#2
Sara F Milrad, Daniel L Hall, Devika R Jutagir, Emily G Lattie, Sara J Czaja, Dolores M Perdomo, Mary Ann Fletcher, Nancy Klimas, Michael H Antoni
INTRODUCTION: Chronic Fatigue Syndrome (CFS) is a poorly understood illness that is characterized by diverse somatic symptoms, hypothalamic pituitary adrenal (HPA) axis dysfunction and heightened inflammatory indicators. These symptoms are often exacerbated and accompanied by psychological distress states and depression. Since depression is known to be associated with HPA axis dysfunction and greater inflammation, a psychoneuroendocrinological (PNE) model of inflammation was examined in persons diagnosed with CFS in order to uncover underlying biopsychosocial mechanisms in this poorly understood chronic illness...
September 13, 2017: International Journal of Psychophysiology
https://www.readbyqxmd.com/read/28886135/differential-regulation-of-innate-immune-cytokine-production-through-pharmacological-activation-of-nuclear-factor-erythroid-2-related-factor-2-nrf2-in-burn-patient-immune-cells-and-monocytes
#3
Timothy K Eitas, Wesley Stepp, Lucas Sjeklocha, Clayton Long, Caitlin Riley, James Callahan, Yolanda Sanchez, Peter Gough, Laquanda Knowlin, David van Duin, Shiara Ortiz-Pujols, Samuel Jones, Robert Maile, Zhi Hong, Scott Berger, Bruce Cairns
Burn patients suffer from immunological dysfunction for which there are currently no successful interventions. Similar to previous observations, we find that burn shock patients (≥15% Total Burn Surface Area (TBSA) injury) have elevated levels of the innate immune cytokines Interleukin-6 (IL-6) and Monocyte Chemoattractant Protein-1 (MCP-1)/CC-motif Chemokine Ligand 2(CCL2) early after hospital admission (0-48 Hours Post-hospital Admission (HPA). Functional immune assays with patient Peripheral Blood Mononuclear Cells (PBMCs) revealed that burn shock patients (≥15% TBSA) produced elevated levels of MCP-1/CCL2 after innate immune stimulation ex vivo relative to mild burn patients...
2017: PloS One
https://www.readbyqxmd.com/read/28875366/saikosaponin-d-relieves-unpredictable-chronic-mild-stress-induced-depressive-like-behavior-in-rats-involvement-of-hpa-axis-and-hippocampal-neurogenesis
#4
Hong-Yan Li, Ying-Hua Zhao, Min-Jie Zeng, Fang Fang, Min Li, Ting-Ting Qin, Lu-Yu Ye, Hong-Wei Li, Rong Qu, Shi-Ping Ma
RATIONALE: Saikosaponin D (SSD), a major bioactive component isolated from Radix Bupleuri, has been reported to exert neuroprotective properties. OBJECTIVES: The present study was designed to investigate the anti-depressant-like effects and the potential mechanisms of SSD. METHODS: Behavioural tests including sucrose preference test (SPT), open field test (OFT) and forced swim test (FST) were performed to study the antidepressant-like effects of SSD...
September 5, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/28866130/differential-effects-of-imipramine-and-cort118335-glucocorticoid-receptor-modulator-mineralocorticoid-receptor-antagonist-on-brain-endocrine-stress-responses-and-depression-like-behavior-in-female-rats
#5
Elizabeth T Nguyen, Jody L Caldwell, Joshua Streicher, Valentina Ghisays, Nikolaus J Balmer, Christina M Estrada, Matia B Solomon
Depression is commonly associated with hypothalamic-pituitary adrenal (HPA) axis dysfunction that primarily manifests as aberrant glucocorticoid secretion. Glucocorticoids act on Type I mineralocorticoid (MR) and Type II glucocorticoid receptors (GR) to modulate mood and endocrine responses. Successful antidepressant treatment normalizes HPA axis function, in part due to modulatory effects on MR and GR in cortico-limbic structures. Although women are twice as likely to suffer from depression, little is known about how antidepressants modulate brain, endocrine, and behavioral stress responses in females...
September 1, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28859148/stellate-ganglion-block-attenuates-chronic-stress-induced-depression-in-rats
#6
Weiwei Wang, Weidong Shi, Hua Qian, Xijin Deng, Tong Wang, Wenzhi Li
BACKGROUND: Stress is a significant factor in the etiology of depression. Stellate ganglion block (SGB) has been shown to maintain the stability of the autonomic system and to affect the neuroendocrine system, including the hypothalamic-pituitary-adrenal (HPA) axis. The objective of this study was to determine the antidepressant-like effects of SGB on the autonomic system and the HPA axis, apoptosis-related proteins, related spatial learning and memory impairment, and sensorimotor dysfunction...
2017: PloS One
https://www.readbyqxmd.com/read/28771175/association-between-mastication-the-hippocampus-and-the-hpa-axis-a-comprehensive-review
#7
REVIEW
Kagaku Azuma, Qian Zhou, Masami Niwa, Kin-Ya Kubo
Mastication is mainly involved in food intake and nutrient digestion with the aid of teeth. Mastication is also important for preserving and promoting general health, including hippocampus-dependent cognition. Both animal and human studies indicate that mastication influences hippocampal functions through the end product of the hypothalamic-pituitary-adrenal (HPA) axis, glucocorticoid (GC). Epidemiologic studies suggest that masticatory dysfunction in aged individuals, such as that resulting from tooth loss and periodontitis, acting as a source of chronic stress, activates the HPA axis, leading to increases in circulating GCs and eventually inducing various physical and psychological diseases, such as cognitive impairment, cardiovascular disorders, and osteoporosis...
August 3, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28740098/puerarin-ameliorated-the-behavioral-deficits-induced-by-chronic-stress-in-rats
#8
Zhi-Kun Qiu, Guan-Hua Zhang, De-Sheng Zhong, Jia-Li He, Xu Liu, Ji-Sheng Chen, Da-Nian Wei
The present study aimed to investigate the mechanisms underlying the antidepressant-like effects of puerarin via the chronic unpredictable stress (CUS) procedure in rats. Similar to Sertraline (Ser), Chronic treatment of puerarin (60 and 120 mg/kg, i.g) elicited the antidepressant-like effects by reversing the decreased sucrose preference in sucrose preference test (SPT), by blocking the increased latency to feed in novelty-suppressed feeding test (NSFT) and the increased immobility time in forced swimming test (FST) without affecting locomotor activity...
July 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28738312/habitual-sleep-quality-and-diurnal-rhythms-of-salivary-cortisol-and-dehydroepiandrosterone-in-postmenopausal-women
#9
Tianyi Huang, Elizabeth M Poole, Celine Vetter, Kathryn M Rexrode, Laura D Kubzansky, Eva Schernhammer, Nicolas Rohleder, Frank B Hu, Susan Redline, Shelley S Tworoger
Dysregulation of the hypothalamus-pituitary-adrenal (HPA) axis has been suggested as a potential mechanism linking sleep and cardiometabolic disorders. However, the associations of two primary outputs of the HPA axis, cortisol and its antagonist dehydroepiandrosterone (DHEA), with sleep are less well studied. In the Nurses' Health Study II, 233 postmenopausal women provided five timed saliva samples over one day (immediately upon waking, 45min, 4h, and 10h after waking, and prior to going to sleep) to measure cortisol and DHEA...
October 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28733038/ferulic-acid-reverses-depression-like-behavior-and-oxidative-stress-induced-by-chronic-corticosterone-treatment-in-mice
#10
Ana Lúcia Bertarello Zeni, Anderson Camargo, Ana Paula Dalmagro
Corticosterone (CORT) treatment has been evidenced to develop a depression-like state in animals, that mimic hypothalamic-pituitary-adrenal (HPA)-axis dysregulation implicated in the development of depression. The present study aimed to examine the ferulic acid (FA), a natural phenolic compound, antidepressant and antioxidant activities on the CORT chronic model. Mice orally treated with 20mg/kg of CORT for 21days were connsidered control group, while mice treated with FA (1mg/kg) or fluoxetine (10mg/kg) for the last week of CORT treatment, as drug groups...
July 19, 2017: Steroids
https://www.readbyqxmd.com/read/28714388/the-prospective-role-of-micrornas-in-depression
#11
Zhiying Hu, Yuting Jiang, Xue Huo, Yang Yang, Henry Davies, Benson O A Botchway, Marong Fang
Depression is a debilitating disease that is affecting a growing number of patients both physically and mentally. In addition to the mood changes, depression causes cognitive impairment, including learning and memory dysfunction. Although depression studies have been going on for decades, the underlying mechanism still remains unclear. MicroRNAs (miRNAs), a type of small non-coding RNAs, predominantly control the expression of their target mRNAs to exert their functions. Some evidence has revealed the importance of miRNAs in the mechanism of depression though the studies are still in their infancy...
July 14, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28694701/high-levels-of-nesfatin-1-in-relation-to-the-dysfunction-of-the-hypothalamic-pituitary-adrenal-and-hypothalamus-pituitary-thyroid-axes-in-depressed-patients-with-subclinical-hypothyroidism
#12
Ya-Yun Xu, Jun Liang, Yin Cao, Feng Shan, Yang Liu, Qing-Rong Xia
Despite the increasing amount of evidence suggesting a relationship between depression and subclinical hypothyroidism (SCH), the exact mechanism underlying this relationship remains unclear. The main purpose of this study was to investigate the roles of plasma Nesfatin-1 levels and dysfunction of the hypothalamic-pituitary-adrenal (HPA) and hypothalamus-pituitary-thyroid (HPT) axes in the comorbidity of depression and SCH. Dysfunctions of the HPA and HPT axes were detected by measuring plasma corticosterone and thyroid-stimulating hormone (TSH) concentrations, respectively...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28694433/antidepressant-effect-of-taurine-in-chronic-unpredictable-mild-stress-induced-depressive-rats
#13
Gao-Feng Wu, Shuang Ren, Ri-Yi Tang, Chang Xu, Jia-Qi Zhou, Shu-Mei Lin, Ying Feng, Qun-Hui Yang, Jian-Min Hu, Jian-Cheng Yang
Depression, a psychiatric and dysthymic disorder, severely affects the learning, work and life quality. The main pathogenesis of depression is associated with central nervous system (CNS) dysfunction. Taurine has been demonstrated to exert protective effects on the brain development and can improve learning ability and memory. Our study investigated the antidepressant-like effects of taurine pre-treatment by examining the changes in depression-like behavior, hormones, neurotransmitters, inflammatory factors and neurotrophic factors in the hippocampus of a chronic unpredictable mild stress (CUMS)-induced depressive rat model...
July 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28686326/single-nucleotide-polymorphisms-in-genes-related-to-the-hypothalamic-pituitary-adrenal-axis-as-risk-factors-for-posttraumatic-stress-disorder
#14
REVIEW
Carolina M Carvalho, Bruno M Coimbra, Vanessa K Ota, Marcelo F Mello, Sintia I Belangero
Posttraumatic stress disorder (PTSD) is a common psychiatric disorder. The etiology of PTSD is multifactorial, depending on many environmental and genetic risk factors, and the exposure to life or physical integrity-threatening events. Several studies have shown significant correlations of many neurobiological findings with PTSD. Hypothalamic-pituitary-adrenal (HPA) axis dysfunction is strongly correlated with this disorder. One hypothesis is that HPA axis dysfunction may precede the traumatic event, suggesting that genes expressed in the HPA axis may be involved in the development of PTSD...
July 7, 2017: American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics
https://www.readbyqxmd.com/read/28669898/relevance-of-tissue-specific-subunit-expression-in-channelopathies
#15
REVIEW
Hartwig Seitter, Alexandra Koschak
Channelopathies are a diverse group of human disorders that are caused by mutations in genes coding for ion channels or channel-regulating proteins. Several dozen channelopathies have been identified that involve both non-excitable cells as well as electrically active tissues like brain, skeletal and smooth muscle or the heart. In this review, we start out from the general question which ion channel genes are expressed tissue-selectively. We mined the human gene expression database Human Protein Atlas (HPA) for tissue-enriched ion channel genes and found 85 genes belonging to the ion channel families...
June 29, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/28666938/death-of-adrenocortical-cells-during-murine-acute-t-cruzi-infection-is-not-associated-with-tnf-r1-signaling-but-mostly-with-the-type-ii-pathway-of-fas-mediated-apoptosis
#16
Ana R Pérez, Flavia Lambertucci, Florencia B González, Eduardo A Roggero, Oscar A Bottasso, Juliana de Meis, Maria T Ronco, Silvina R Villar
Earlier studies from our laboratory demonstrated that acute experimental Trypanosoma cruzi infection promotes an intense inflammation along with a sepsis-like dysregulated adrenal response characterized by normal levels of ACTH with raised glucocorticoid secretion. Inflammation was also known to result in adrenal cell apoptosis, which in turn may influence HPA axis uncoupling. To explore factors and pathways which may be involved in the apoptosis of adrenal cells, together with its impact on the functionality of the gland, we carried out a series of studies in mice lacking death receptors, such as TNF-R1 (C57BL/6-(Tnfrsf1a tm1Imx) or TNF-R1(-/-)) or Fas ligand (C57BL/6 Fas-deficient lpr mice), undergoing acute T...
June 27, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/28639383/longitudinal-associations-between-low-morning-cortisol-in-infancy-and-anger-dysregulation-in-early-childhood-in-a-cps-referred-sample
#17
Allison Frost, Caitlin Jelinek, Kristin Bernard, Teresa Lind, Mary Dozier
Children who experience early adversity are at increased risk for developing psychopathology, and dysfunction of the hypothalamic pituitary adrenal (HPA) axis is a possible mechanism conferring this risk. This study sought to characterize the association between morning cortisol during different developmental periods and deficits in children's emotion regulation, a core feature of many psychological disorders. Morning cortisol was collected at two time points (i.e., during infancy, M = 13.0 months old, and during early childhood, M = 36...
June 21, 2017: Developmental Science
https://www.readbyqxmd.com/read/28623763/saturated-high-fat-feeding-independent-of-obesity-alters-hypothalamus-pituitary-adrenal-axis-function-but-not-anxiety-like-behaviour
#18
Cecile Hryhorczuk, Léa Décarie-Spain, Sandeep Sharma, Caroline Daneault, Christine Des Rosiers, Thierry Alquier, Stephanie Fulton
Overconsumption of dietary fat can elicit impairments in emotional processes and the response to stress. While excess dietary lipids have been shown to alter hypothalamus-pituitary-adrenal (HPA) axis function and promote anxiety-like behaviour, it is not known if such changes rely on elevated body weight and if these effects are specific to the type of dietary fat. The objective of this study was to investigate the effect of a saturated and a monounsaturated high-fat diet (HFD) on HPA axis function and anxiety-like behaviour in rats...
June 10, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28618657/antidepressive-effects-of-ginsenoside-rg1-via-regulation-of-hpa-and-hpg-axis
#19
Zheng Mou, Qian Huang, Shi-Feng Chu, Mei-Jin Zhang, Jin-Feng Hu, Nai-Hong Chen, Jun-Tian Zhang
BACKGROUND: Hypothalamic-pituitary-adrenal (HPA) axis hyperactivity is a well-established pathological feature of major depression, accompanied by the persistent increase of glucocorticoid level and the dysfunction of hypothalamic-pituitary-gonadal (HPG) axis. Ginsenoside Rg1 (Rg1) is one of the most active ingredients of Panax ginseng, which has various biological activity. OBJECTIVE: This study aimed to investigate the antidepressive effects of Rg1 and elucidate its impact on neuroendocrine system...
August 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28584278/environmental-novelty-exacerbates-stress-hormones-and-a%C3%AE-pathology-in-an-alzheimer-s-model
#20
Kimberley E Stuart, Anna E King, Carmen M Fernandez-Martos, Mathew J Summers, James C Vickers
Cognitive stimulation has been proposed as a non-pharmacological intervention to be used in primary, secondary and tertiary prevention approaches for Alzheimer's disease. A common familial Alzheimer's disease transgenic model showed heightened levels of the stress hormone, corticosterone. When exposed to periodic enhanced cognitive stimulation, these animals demonstrated further heightened levels of corticosterone as well as increased Aβ pathology. Hence, Alzheimer's disease may be associated with hypothalamic-pituitary-adrenal (HPA) axis dysfunction, causing stimulatory environments to become stress-inducing, leading to a glucocorticoid-pathology cycle contributing to further Aβ release and plaque formation...
June 5, 2017: Scientific Reports
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