keyword
MENU ▼
Read by QxMD icon Read
search

Th1/th2

keyword
https://www.readbyqxmd.com/read/28923981/pillars-article-m-1-m-2-macrophages-and-the-th1-th2-paradigm-j-immunol-2000-164-6166-6173
#1
Charles D Mills, Kristi Kincaid, Jennifer M Alt, Michelle J Heilman, Annette M Hill
No abstract text is available yet for this article.
October 1, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28923825/qualitative-differences-in-t-cell-activation-by-dendritic-cell-derived-extracellular-vesicle-subtypes
#2
Mercedes Tkach, Joanna Kowal, Andres E Zucchetti, Lotte Enserink, Mabel Jouve, Danielle Lankar, Michael Saitakis, Lorena Martin-Jaular, Clotilde Théry
Exosomes, nano-sized secreted extracellular vesicles (EVs), are actively studied for their diagnostic and therapeutic potential. In particular, exosomes secreted by dendritic cells (DCs) have been shown to carry MHC-peptide complexes allowing efficient activation of T lymphocytes, thus displaying potential as promoters of adaptive immune responses. DCs also secrete other types of EVs of different size, subcellular origin and protein composition, whose immune capacities have not been yet compared to those of exosomes...
September 18, 2017: EMBO Journal
https://www.readbyqxmd.com/read/28923131/innate-and-adaptive-immune-response-to-chronic-pulmonary-infection-of-hyphae-of-aspergillus-fumigatus-in-a-new-murine-model
#3
Fengyuan Wang, Caiyun Zhang, Yuan Jiang, Caixia Kou, Qingtao Kong, Nanbiao Long, Ling Lu, Hong Sang
PURPOSE: The pathogenesis of chronic pulmonary aspergillosis (CPA) has seldom been studied due partly to a lack of animal models. Since hypha is the main morphology colonizing the airway in CPA, it's critical to study the immune reaction to chronic pulmonary infection of hyphae of Aspergillus fumigatus, which also has seldom been studied in vivo before. METHODOLOGY: We established a novel murine model of chronic pulmonary infection of hyphae by challenging immunocompetent mice with tightly-structured hyphae balls intratracheally, and described the ensuing immunoreaction to hyphae and conidia, and the pathogenesis of CPA...
September 19, 2017: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/28922426/a-dna-vaccine-for-crimean-congo-hemorrhagic-fever-protects-against-disease-and-death-in-two-lethal-mouse-models
#4
Aura R Garrison, Charles J Shoemaker, Joseph W Golden, Collin J Fitzpatrick, John J Suschak, Michelle J Richards, Catherine V Badger, Carolyn M Six, Jacqueline D Martin, Drew Hannaman, Marko Zivcec, Eric Bergeron, Jeffrey W Koehler, Connie S Schmaljohn
Crimean-Congo hemorrhagic fever virus (CCHFV) is a tick-borne virus capable of causing a severe hemorrhagic fever disease in humans. There are currently no licensed vaccines to prevent CCHFV-associated disease. We developed a DNA vaccine expressing the M-segment glycoprotein precursor gene of CCHFV and assessed its immunogenicity and protective efficacy in two lethal mouse models of disease: type I interferon receptor knockout (IFNAR-/-) mice; and a novel transiently immune suppressed (IS) mouse model. Vaccination of mice by muscle electroporation of the M-segment DNA vaccine elicited strong antigen-specific humoral immune responses with neutralizing titers after three vaccinations in both IFNAR-/- and IS mouse models...
September 18, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28921728/undifferentiated-connective-tissue-diseases-and-adverse-pregnancy-outcomes-an-undervalued-association
#5
REVIEW
Arsenio Spinillo, Fausta Beneventi, Roberto Caporali, Veronique Ramoni, Carlomaurizio Montecucco
Undifferentiated connective tissue diseases (UCTDs) are a heterogeneous group of disorders characterized by symptoms and signs suggestive of systemic autoimmune rheumatic disease (ARD), but which do not fulfill all the established criteria for definite diagnosis of a condition. Although a third of UCTDs can progress to a definite ARD within months or years, most UCTDs can remain stable for years with minimal disease activity. The annual incidence of UCTD in the general population ranges from 14 to 140 per 100 000 people...
September 16, 2017: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/28921566/pegylation-of-cationic-liposomes-encapsulating-soluble-leishmania-antigens-sla-reduces-the-adjuvant-efficacy-of-liposomes-in-murine-model
#6
Hadi Naseri, Faezeh Eskandari, Mahmoud Reza Jaafari, Ali Khamesipour, Azam Abbasi, Ali Badiee
Although there have been several attempts to develop a vaccine against leishmaniasis; no vaccine in human has been developed yet. Liposomes consisting of 1, 2-dioleoyl-3-trimethylammonium-propane (DOTAP) encapsulating soluble Leishmania antigens (SLA) enhance protective immunity of SLA against L. major infection in mice. However, they immobilized at the injection site because of their positive charge. To overcome the problem, shielding the surface charge with polyethylene glycol (PEGylation) was chosen in this study...
September 16, 2017: Parasite Immunology
https://www.readbyqxmd.com/read/28917537/hbcag-produced-in-transgenic-tobacco-triggers-th1-and-th2-response-when-intramuscularly-delivered
#7
Marcin Pyrski, Anna Rugowska, Kamil Robert Wierzbiński, Anna Kasprzyk, Maria Bogusiewicz, Piotr Bociąg, Sławomir Samardakiewicz, Marcin Czyż, Maciej Kurpisz, Tomasz Pniewski
Hepatitis B core Antigen (HBcAg) assembled into Capsid-Like Particles (CLPs) is investigated as a therapeutic vaccine in treatment of chronic hepatitis B (CHB) and in diagnostic tests or as a carrier for various epitopes. While the expression of HBcAg has been thoroughly clarified in E. coli and yeast, it has also been investigated in other expression systems. Stably transformed tobacco expressed HBcAg at a level of 110-250µg/g fresh weight, therefore in view of its large leaf biomass it offers a production platform comparable with transient expression systems regarding the final yield of HBcAg...
September 13, 2017: Vaccine
https://www.readbyqxmd.com/read/28917326/serum-levels-of-cytokines-in-water-buffaloes-experimentally-infected-with-fasciola-gigantica
#8
Fu-Kai Zhang, Ai-Jiang Guo, Jun-Ling Hou, Miao-Miao Sun, Zhao-An Sheng, Xiao-Xuan Zhang, Wei-Yi Huang, Hany M Elsheikha, Xing-Quan Zhu
Fasciola gigantica infection in water buffaloes causes significant economic losses especially in developing countries. Although modulation of the host immune response by cytokine neutralization or vaccination is a promising approach to control infection with this parasite, our understanding of cytokine's dynamic during F. gigantica infection is limited. To address this, we quantified the levels of serum cytokines produced in water buffaloes following experimental infection with F. gigantica. Five buffaloes were infected via oral gavage with 500 viable F...
September 15, 2017: Veterinary Parasitology
https://www.readbyqxmd.com/read/28914568/human-embryonic-stem-cell-derived-mesenchymal-stromal-cells-decrease-the-development-of-severe-experimental-autoimmune-uveitis-in-b10-riii-mice
#9
Yu Qin, Ann M Chan, Yu-Ling Chang, Anna Matynia, Nicholas A Kouris, Erin A Kimbrel, Negin Ashki, Sachin Parikh, Michael B Gorin, Robert Lanza, Ralph D Levinson, Lynn K Gordon
PURPOSE: We investigated the effect of exogenously administered human embryonic stem cell-derived mesenchymal stromal cells (hESC-MSCs) in experimental autoimmune uveitis (EAU) in B10.RIII mice, a murine model of severe uveitis. METHODS: B10.RIII mice were immunized with an uveitogenic peptide, and intraperitoneal injections of 5 million hESC-MSCs per animal were given on the same day. Behavioral light sensitivity assays, histological evaluation, cytokine production, and regulatory T cells were analyzed at the peak of the disease...
September 15, 2017: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/28906131/effects-of-immunomodulators-on-the-response-induced-by-vaccines-against-autoimmune-diseases
#10
Dante J Marciani
A promising treatment for T-cell-mediated autoimmune diseases is the induction of immune tolerance by modulating the immune response against self-antigens, an objective that may be achieved by vaccination. There are two main types of vaccines currently under development. The tolerogenic vaccines, composed of proteins formed by a cytokine fused to a self-antigen, which usually induce tolerance by eliminating the T-cells that are immune reactive against the self-antigen. The immunogenic vaccines, comprised of a self-antigen plus a sole Th2 adjuvant either free or conjugated, that alleviate autoimmunity by switching the immune response against the self-antigen, from a damaging pro-inflammatory Th1/Th17 to an anti-inflammatory Th2 immunity...
September 14, 2017: Autoimmunity
https://www.readbyqxmd.com/read/28903402/impact-of-chronic-methamphetamine-treatment-on-the-atherosclerosis-formation-in-apoe-mice-fed-a-high-cholesterol-diet
#11
Pengfei Zhu, Lun Li, Bo Gao, Mingjing Zhang, Yuting Wang, Ye Gu, Liqun Hu
BACKGROUND: We previously reported that methamphetamine could promote atherosclerosis (AS) in ApoE-/- mice fed normal chow. We herein observed the impact of methamphetamine on AS in ApoE-/- mice fed a high cholesterol diet and explored the potential mechanisms. RESULTS AND MATERIALS AND METHODS: Male ApoE-/- mice fed a high cholesterol diet were treated with saline (NS, n = 5) or methamphetamine [8 mg/kg/day (M8, n = 6) through intraperitoneal injection] for 24 weeks...
August 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28900758/in-utero-development-of-memory-t-cells
#12
REVIEW
Dania Zhivaki, Richard Lo-Man
Pathogen-specific immune memory develops subsequent to primary exposure to antigen, mainly in the context of infection or vaccination to provide protection. Although a safe fetal life requires a tolerogenic environment in order to circumvent unnecessary inflammatory responses, it needs to be prepared in utero to face the microbial environment outside the womb. The possibility of immune memory generation in the fetus would help such transition providing protection in early life. This requires fetal T cell exposure to foreign antigens presented by dendritic cells...
September 12, 2017: Seminars in Immunopathology
https://www.readbyqxmd.com/read/28900244/il-4-enhances-il-10-production-in-th1-cells-implications-for-th1-and-th2-regulation
#13
Ruth E Mitchell, Masriana Hassan, Bronwen R Burton, Graham Britton, Elaine V Hill, Johan Verhagen, David C Wraith
IL-10 is an immunomodulatory cytokine with a critical role in limiting inflammation in immune-mediated pathologies. The mechanisms leading to IL-10 expression by CD4(+) T cells are being elucidated, with several cytokines implicated. We explored the effect of IL-4 on the natural phenomenon of IL-10 production by a chronically stimulated antigen-specific population of differentiated Th1 cells. In vitro, IL-4 blockade inhibited while addition of exogenous IL-4 to Th1 cultures enhanced IL-10 production. In the in vivo setting of peptide immunotherapy leading to a chronically stimulated Th1 phenotype, lack of IL-4Rα inhibited the induction of IL-10...
September 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28899400/impact-of-combined-sodium-chloride-and-saturated-long-chain-fatty-acid-challenge-on-the-differentiation-of-t-helper-cells-in-neuroinflammation
#14
Anna Hammer, Anne Schliep, Stefanie Jörg, Aiden Haghikia, Ralf Gold, Markus Kleinewietfeld, Dominik N Müller, Ralf A Linker
BACKGROUND: There has been a marked increase in the incidence of autoimmune diseases like multiple sclerosis (MS) in the last decades which is most likely driven by a change in environmental factors. Here, growing evidence suggests that ingredients of a Western diet like high intake of sodium chloride (NaCl) or saturated fatty acids may impact systemic immune responses, thus increasing disease susceptibility. Recently, we have shown that high dietary salt or long-chain fatty acid (LCFA) intake indeed aggravates T helper (Th) cell responses and neuroinflammation...
September 12, 2017: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/28898911/lactobacilus-delbrueckii-subsp-bulgaricus-modulates-the-secretion-of-th1-th2-and-treg-cell-related-cytokines-by-pbmcs-from-patients-with-atopic-dermatitis
#15
Abdolkarim Sheikhi, Hojjat Giti, Mohammad Reza Heibor, Abdollah Jafarzadeh, Mansour Shakerian, Narges Baharifar, Fereidon Niruzad, Ali Sadeghi Moghaddam, Parviz Kokhaei, Mohammad Baghaeifar
Background Atopic dermatitis (AD) is an inflammatory skin disease which may be due to the imbalance between Th1-, Th2 and Treg cell-related immune responses. Evidences suggest that appropriate stimulation with probiotics may correct the skewed immune response in children with AD. The aim was to determine the effects of the yogurt culture lactobacillus Bulgaricus on the secretion of Th1/Th2/Treg type cytokines by PBMCs from children with AD. MethodsL. Bulgaricus was cultivated on MRS broth. The PBMCs from 20 children with AD were separated by Ficoll-Hypaque centrifugation and co-cultured with different concentrations of UV killed bacteria in RPMI-1640 plus 10% FCS for 48/72 h...
September 12, 2017: Drug Research
https://www.readbyqxmd.com/read/28895901/delayed-activation-kinetics-of-th2-and-th17-cells-compared-to-th1-cells
#16
Andrea Duechting, Anna Przybyla, Stefanie Kuerten, Paul V Lehmann
During immune responses, different classes of T cells arise: Th1, Th2, and Th17. Mobilizing the right class plays a critical role in successful host defense and therefore defining the ratios of Th1/Th2/Th17 cells within the antigen-specific T cell repertoire is critical for immune monitoring purposes. Antigen-specific Th1, Th2, and Th17 cells can be detected by challenging peripheral blood mononuclear cells (PBMC) with antigen, and establishing the numbers of T cells producing the respective lead cytokine, IFN-γ and IL-2 for Th1 cells, IL-4 and IL-5 for Th2, and IL-17 for Th-17 cells, respectively...
September 12, 2017: Cells
https://www.readbyqxmd.com/read/28894978/hydrogen-rich-saline-ameliorates-allergic-rhinitis-by-reversing-the-imbalance-of-th1-th2-and-up-regulation-of-cd4-cd25-foxp3-regulatory-t-cells-interleukin-10-and-membrane-bound-transforming-growth-factor-%C3%AE-in-guinea-pigs
#17
Feifei Xu, Shaoqing Yu, Mali Qin, Yong Mao, Ling Jin, Na Che, Shuangxi Liu, Rongming Ge
It is well known that CD4+CD25+Foxp3+Treg cells play an important role in the development of allergic rhinitis (AR); the defect of cell numbers and functions contribute to AR. Hydrogen has been proven effective in alleviating symptoms of AR. We herein aim to verify the protective effects of hydrogen on CD4+CD25+Foxp3+Treg cells in guinea pigs with AR and to explore the effect of hydrogen-rich saline (HRS) on CD4+CD25+Foxp3+Treg cells in animals with AR and investigate the underlying anti-inflammatory mechanism...
September 11, 2017: Inflammation
https://www.readbyqxmd.com/read/28892752/graphene-quantum-dots-suppress-proinflammatory-t-cell-responses-via-autophagy-dependent-induction-of-tolerogenic-dendritic-cells
#18
Sergej Tomić, Kristina Janjetović, Dušan Mihajlović, Marina Milenković, Tamara Kravić-Stevović, Zoran Marković, Biljana Todorović-Marković, Zdenko Spitalsky, Matej Micusik, Dragana Vučević, Miodrag Čolić, Vladimir Trajković
Graphene quantum dots (GQD) are atom-thick nanodimensional carbon sheets with excellent physico-chemical and biological properties, making them attractive for application in theranostics. However, their immunoregulatory properties are insufficiently investigated, especially in human primary immune cells. We found that non-toxic doses of GQD inhibit the production of proinflammatory and T helper (Th)1 cytokines, and augment the production of anti-inflammatory and Th2 cytokines by human peripheral blood mononuclear cells...
August 29, 2017: Biomaterials
https://www.readbyqxmd.com/read/28892576/pregnancy-modulates-the-allergen-induced-cytokine-production-differently-in-allergic-and-non-allergic-women
#19
Martina Sandberg Abelius, Malin Jedenfalk, Jan Ernerudh, Camilla Janefjord, Göran Berg, Leif Matthiesen, Maria C Jenmalm
BACKGROUND: The immunological environment during pregnancy may differ between allergic and non-allergic women. This study investigates the effect of maternal allergy on the allergen-induced cytokine and chemokine levels and if pregnancy modulates these immune responses differently in allergic and non-allergic women. METHODS: The birch-, cat-, phytohemagglutinin- and tetanus toxoid-induced interferon-γ (IFN-γ), interleukin-4 (IL)-4, IL-5, IL-10, IL-13, the T-helper 1 (Th1)-associated chemokine CXCL10 and the Th2-associated chemokine CCL17 levels were quantified in 20 women with allergic symptoms (sensitised, n=13) and 36 women without allergic symptoms (non-sensitised, n=30) at gestational weeks 10-12, 15-16, 25, 35 and 2 and 12 months postpartum...
September 11, 2017: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/28889953/role-of-b-cells-in-t-helper-cell-responses-in-a-mouse-model-of-asthma
#20
Tomasz Piotr Wypych, Roberta Marzi, Gregory F Wu, Antonio Lanzavecchia, Federica Sallusto
BACKGROUND: The importance of B lymphocytes to present antigens for antibody production is well documented. In contrast, very little is known about their capacity to influence CD4(+) T cell activation during primary or secondary response to allergens. OBJECTIVE: Using mouse models of asthma, we investigated the role of B cells as antigen presenting cells in propagation and initiation of T helper cell responses. METHODS: Mice were immunized via intranasal route with house dust mite extract (HDM) derived from Dermatophagoides pteronyssinus...
September 7, 2017: Journal of Allergy and Clinical Immunology
keyword
keyword
69213
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"