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https://www.readbyqxmd.com/read/28944896/microrna%C3%A2-186-targets-igf%C3%A2-1r-and-exerts-tumor%C3%A2-suppressing-functions-in-glioma
#1
Jian Jiang, Weijie Wang, Dazhao Fang, Xiaodong Jin, Lianshu Ding, Xiaoyang Sun
Glioma is the most common malignant brain tumor in adults and represents one of the most aggressive and life‑threatening types of cancer in humans. Increasing studies have revealed that microRNAs are abnormally expressed in various types of human cancer, and have oncogenic or tumor suppressive roles, which depend primarily on the type of cancer. The present study aimed to investigate the expression level and effects of microRNA‑186 (miR‑186) on glioma, and its underlying molecular mechanism. Reverse transcription‑quantitative polymerase chain reaction (RT‑qPCR) analysis was performed to detect the expression of miR‑186 in glioma tissues and cell lines...
September 21, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28944624/immediate-autologous-breast-reconstruction-after-neoadjuvant-chemoradiotherapy-for-breast-cancer-initial-results-of-the-first-29-patients
#2
Damien Grinsell, Meron Pitcher, Shirley Wong, Mario Guerrieri, Hans H M Nielsen
BACKGROUND: Breast reconstruction after mastectomy in the treatment of locally advanced breast cancer is often done in stages and before radiotherapy. We have previously published an algorithm for immediate free autologous reconstruction after neoadjuvant chemotherapy and preoperative radiotherapy. This protocol was designed to provide a shorter and simpler reconstructive path whilst improving cosmesis and maintaining oncological efficiency. METHODS: A total of 29 patients were included and underwent surgery for 30 cancers by the first author between 2010 and September 2015...
September 24, 2017: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/28944562/autoantibodies-against-aldehyde-modified-collagen-type-iv-are-associated-with-risk-of-development-of-myocardial-infarction
#3
J Vallejo, P Dunér, G N Fredrikson, J Nilsson, E Bengtsson
BACKGROUND: Oxidation of LDL particles entrapped in the extracellular matrix of the arterial wall is a key factor in the development of atherosclerosis. Lipid oxidation products, such as malondialdehyde (MDA), react with surrounding extracellular matrix proteins and cause modifications that are recognized by the immune system. MDA modification of collagen type IV is increased in carotid lesions from symptomatic patients and correlates with autoantibodies against MDA-modified collagen type IV in plasma...
September 25, 2017: Journal of Internal Medicine
https://www.readbyqxmd.com/read/28944403/prediction-of-disease-free-survival-by-the-pet-ct-radiomic-signature-in-non-small-cell-lung-cancer-patients-undergoing-surgery
#4
Margarita Kirienko, Luca Cozzi, Lidija Antunovic, Lisa Lozza, Antonella Fogliata, Emanuele Voulaz, Alexia Rossi, Arturo Chiti, Martina Sollini
PURPOSE: Radiomic features derived from the texture analysis of different imaging modalities e show promise in lesion characterisation, response prediction, and prognostication in lung cancer patients. The present study aimed to identify an images-based radiomic signature capable of predicting disease-free survival (DFS) in non-small cell lung cancer (NSCLC) patients undergoing surgery. METHODS: A cohort of 295 patients was selected. Clinical parameters (age, sex, histological type, tumour grade, and stage) were recorded for all patients...
September 24, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28944331/assessment-of-the-relationship-between-neutrophil-lymphocyte-ratio-and-prognostic-factors-in-non-metastatic-colorectal-cancer
#5
Ersin Borazan, Ahmet Abdulhalik Balık, Zehra Bozdağ, Muhammed Kasım Arık, Alper Aytekin, Latif Yılmaz, Muhsin Elçi, İlyas Başkonuş
OBJECTIVE: Neutrophil-lymphocyte ratio still has a limited clinical use due to many non-cancer factors affecting neutrophils or lymphocytes in the present time. We aimed to evaluate the association between preoperative neutrophil-lymphocyte ratio and poor prognostic factors after curative elective colorectal surgery. MATERIAL AND METHODS: This clinical retrospective study was initiated with 95 patients, who had a curative surgical resection between 2003 and 2013...
2017: Turk J Surg
https://www.readbyqxmd.com/read/28944218/diabetes-mitigates-the-role-of-memory-complaint-in-predicting-dementia-risk-results-from-the-prevention-of-alzheimer-s-disease-with-vitamin-e-and-selenium-study
#6
X Zhang, F A Schmitt, A M Caban-Holt, X Ding, R J Kryscio, E Abner
BACKGROUND: Subjective memory complaints (SMCs) are associated with increased risk of dementia in older adults, but the role of comorbidities in modifying this risk is unknown. OBJECTIVES: To assess whether comorbidities modify estimated dementia risk based on SMCs. DESIGN: The Prevention of Alzheimer's Disease with Vitamin E and Selenium Study (PREADVISE) was designed as an ancillary study to the Selenium and Vitamin E Cancer Prevention Trial (SELECT), a randomized, multi-center prostate cancer prevention trial with sites in the Unites States, Puerto Rico, and Canada...
2017: Journal of Prevention of Alzheimer's Disease
https://www.readbyqxmd.com/read/28943963/expression-of-the-tumor-suppressor-gene-p16-and-lymph-node-metastasis-in-patients-with-ovarian-cancer
#7
Hongyan Wang, Jingfang Zheng, Qiang Li, Min Zhou, Dongmei Ai, Hui Zhang
This study examined the relationship between the expression of p16, a tumor suppressor gene, and lymph node metastasis, as well as patient prognosis, in cases with ovarian cancer. SKOV-3, an ovarian cancer cell line, and IOSE80, a normal human ovarian cell line, were selected for testing. Western blot analysis was used to detect the p16 expression in ovarian cell culture samples. In the study, 20 cases with normal ovarian tissue and 64 cases with ovarian cancer tissue, including 38 cases with lymph node metastasis and 26 cases without lymph node metastasis, were also selected for testing...
October 2017: Oncology Letters
https://www.readbyqxmd.com/read/28943957/microrna-141-is-a-tumor-regulator-and-prognostic-biomarker-in-human-glioblastoma
#8
Xuehua Xiong, Jianping Deng, Chun Zeng, Yongming Jiang, Shuang Tang, Xiaochuan Sun
Human glioblastoma is one of the most malignant types of brain tumor in the world. In the present study, the functional mechanisms of microRNA-141 (miR-141) were assessed, and the potential role of miR-141 as a prognostic biomarker in glioblastoma was examined. The gene expression of miR-141 in glioblastoma cell lines and glioblastoma tumors was assessed by reverse transcription-quantitative polymerase chain reaction. Glioblastoma LN229 and U89 cell lines were transfected with synthetic miR-141 mimics to upregulate endogenous miR-141...
October 2017: Oncology Letters
https://www.readbyqxmd.com/read/28943955/p53-inhibits-the-upregulation-of-sirtuin-1-expression-induced-by-c-myc
#9
Fang Yuan, Lu Liu, Yonghong Lei, Peifu Tang
Sirtuin 1 (Sirt1), a conserved NAD(+) dependent deacetylase, is a mediator of life span by calorie restriction. However, Sirt1 may paradoxically increase the risk of cancer. Accordingly, the expression level of Sirt1 is selectively elevated in numerous types of cancer cell; however, the mechanisms underlying the differential regulation remain largely unknown. The present study demonstrated that oncoprotein c-Myc was a direct regulator of Sirt1, which accounts for the upregulation of Sirt1 expression only in the cells without functional p53...
October 2017: Oncology Letters
https://www.readbyqxmd.com/read/28943939/low-expression-of-microrna-1908-predicts-a-poor-prognosis-for-patients-with-ovarian-cancer
#10
Changcai Teng, Hong Zheng
MicroRNAs (miRs) serve important roles in cancer genesis and progression. The expression of miR-1908 has been reported in a number of types of cancer; however, the clinical significance of miR-1908 in human ovarian cancer (OC) remains unclear. A total of 491 patients with OC from The Cancer Genome Atlas project cohort were selected and divided into two groups according to the median expression level of miR-1908. Univariate and multivariate analyses, using the Kaplan-Meier method and Cox regression, were performed to identify the characteristics that predict OC prognosis...
October 2017: Oncology Letters
https://www.readbyqxmd.com/read/28943928/recq-helicase-blm-regulates-prostate-cancer-cell-proliferation-and-apoptosis
#11
Xiaosong Qian, Sujuan Feng, Dawei Xie, Dalin Feng, Yihang Jiang, Xiaodong Zhang
Prostate cancer (PCa) is a common malignant tumor and the second leading cause of morbidity and mortality in men worldwide. Considering the prevalence and effects of PCa in males, an understanding of the molecular mechanisms underlying PCa tumorigenesis are essential and may provide novel therapeutic strategies for treating PCa. Bloom syndrome protein (BLM) is a member of the RecQ helicase family. The major function of BLM is to uncoil the double-stranded DNA structure. It has previously been demonstrated that BLM acts as a 'genome caretaker', and dysregulation of BLM function has been implicated in the development of multiple tumor types; however, its potential for inducing PCa tumorigenesis remains undetermined...
October 2017: Oncology Letters
https://www.readbyqxmd.com/read/28943919/braf-v600e-mutation-is-not-associated-with-central-lymph-node-metastasis-in-all-patients-with-papillary-thyroid-cancer-different-histological-subtypes-and-preoperative-lymph-node-status-should-be-taken-into-account
#12
Si-Yang Dong, Rui-Chao Zeng, Lang-Ping Jin, Fan Yang, Xiang-Jian Zhang, Zhi-Han Yao, Xiao-Hua Zhang, Ou-Chen Wang
The association between central lymph node metastasis (LNM) and risk factors, including the presence of the BRAF mutation, BRAF(V600E), in patients with papillary thyroid cancer (PTC) requires further investigation. A potent risk factor that can indicate LNM in different histological subtypes of PTC and in different preoperative central lymph node statuses also requires further research. A total of 287 patients with PTC who accepted thyroidectomy were included in the present study. Clinicopathological data of these patients were reviewed to examine the risk factors for central LNM through univariate and multivariate analyses...
October 2017: Oncology Letters
https://www.readbyqxmd.com/read/28943640/exercise-dependent-regulation-of-the-tumour-microenvironment
#13
REVIEW
Graeme J Koelwyn, Daniela F Quail, Xiang Zhang, Richard M White, Lee W Jones
The integrity and composition of the tumour microenvironment (TME) is highly plastic, undergoing constant remodelling in response to instructive signals derived from alterations in the availability and nature of systemic host factors. This 'systemic milieu' is directly modulated by host exposure to modifiable lifestyle factors such as exercise. Host exposure to regular exercise markedly reduces the risk of the primary development of several cancers and might improve clinical outcomes following a diagnosis of a primary disease...
September 25, 2017: Nature Reviews. Cancer
https://www.readbyqxmd.com/read/28943330/comparison-of-surgery-and-radiation-as-local-treatments-in-the-risk-of-locoregional-complications-in-men-subsequently-dying-from-prostate-cancer
#14
Jason Hu, Armen G Aprikian, Fabio L Cury, Marie Vanhuyse, Ahmed S Zakaria, Patrick O Richard, Sylvie Perreault, Alice Dragomir
INTRODUCTION: Late locoregional complications in prostate cancer (PCa) affect quality of life and require medical interventions. Our objective was to compare late locoregional complications in men dying of castration-resistant PCa (CRPC) who previously received external-beam radiotherapy (EBRT) to radical prostatectomy (RP). No group without previous primary local treatment was included. PATIENTS AND METHODS: The cohort consists of CRPC patients who died between 2001 and 2013 and who underwent previous EBRT or RP...
September 5, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/28943178/factors-associated-with-degree-of-tumour-response-to-neo-adjuvant-radiotherapy-in-rectal-cancer-and-subsequent-corresponding-outcomes
#15
K J Gash, O Baser, R P Kiran
BACKGROUND: Tumour response to neo-adjuvant radiotherapy for rectal cancer varies significantly between patients, as classified by Tumour Regression Grade (TRG 0-3), with 0 equating to pathological complete response (pCR) and 3 denoting minimal/no response. pCR is associated with significantly better local recurrence rates and survival, but is achieved in only 20-30% of patients. The literature contains limited data reporting factors predictive of tumour response and corresponding outcomes according to degree of regression...
August 10, 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28943022/patient-reported-quality-of-life-outcomes-following-treatment-for-oral-cancer
#16
J Breeze, A Rennie, D Dawson, J Tipper, K-U Rehman, N Grew, N Pigadas
Patient-reported quality of life (QoL) outcomes have the potential to assist clinicians in providing individually tailored treatment decisions. QoL assessments were collected prospectively for 168 consecutive patients treated for oral cancer between 1 January 2010 and 31 December 2014 using the University of Washington Quality of Life Questionnaire. Patients were followed up for 18 months post-treatment. Sub-group analyses were performed using paired t-tests and analysis of variance (ANOVA) to compare the effects of adjunctive chemoradiotherapy, type of bone resection, and methods of soft and hard tissue flap reconstruction...
September 21, 2017: International Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28943004/importance-of-postprocedural-wound-ischemia-and-foot-infection-wifi-restaging-in-predicting-limb-salvage
#17
Charles Leithead, Zdenek Novak, Emily Spangler, Marc A Passman, Adam Witcher, Mark A Patterson, Adam W Beck, Benjamin J Pearce
OBJECTIVE: The Wound, Ischemia, and foot Infection (WIfI) classification system was created to encompass demographic changes and expanding techniques of revascularization to perform meaningful analyses of outcomes in the treatment of the threatened limb. The WIfI index is intended to be analogous to the TNM staging system for cancer, with restaging to be done after control of infection and after revascularization. Our goal was to evaluate the effectiveness of WIfI restaging after therapy in the prediction of limb outcomes...
September 21, 2017: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/28942909/a-systematic-review-of-exercise-systematic-reviews-in-the-cancer-literature-2005-2017
#18
REVIEW
Nicole L Stout, Jennifer Baima, Anne K Swisher, Kerri M Winters-Stone, Judith Welsh
BACKGROUND: Evidence supports the benefits of exercise for patients with cancer; however, specific guidance for clinical decision making regarding exercise timing, frequency, duration, and intensity is lacking. Efforts are needed to optimize clinical recommendations for exercise in the cancer population. OBJECTIVES: To aggregate information regarding the benefit of exercise through a systematic review of existing systematic reviews in the cancer exercise literature...
September 2017: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/28942747/prevalence-correlates-and-impact-of-depressive-and-anxiety-disorder-in-cancer-findings-from-a-multicenter-study
#19
Eun-Jung Shim, Bong-Jin Hahm, Eun-Seung Yu, Ha Kyoung Kim, Seong Jin Cho, Sung Man Chang, Jong-Chul Yang, Jong-Heun Kim
OBJECTIVE: Our aim was to examine the prevalence, correlates, and association of depressive and anxiety disorders with quality of life (QoL) and such other outcomes as the need for psychosocial services in cancer patients. METHOD: A total of 400 patients participated in a multicenter survey involving five cancer centers located throughout Korea. The Short-Form Health Survey, the MD Anderson Symptom Inventory, the Mini-Mental Adjustment to Cancer (MINI-MAC), and Mini-International Neuropsychiatric Interview were administered...
September 25, 2017: Palliative & Supportive Care
https://www.readbyqxmd.com/read/28942671/a-new-2-alkylhydroquinone-glucoside-from-phagnalon-saxatile-l-cass
#20
Hanene Cherchar, Meriem Lehbili, Djemaa Berrehal, Hamid Morjani, Abdulmagid Alabdul Magid, Laurence Voutquenne-Nazabadioko, Ahmed Kabouche, Zahia Kabouche
A new 2-alkylhydroquinone glucoside, 1-O-β-d-glucopyranosyl-1,4-dihydroxy-2-((E) 2-oxo-3-butenyl)benzene (1), in addition to nine known compounds were isolated from the aerial parts of Phagnalon saxatile (L.) Cass. (Asteraceae). Their structures were identified based on spectroscopic methods including 1D and 2D NMR, mass spectrometry (HR-ESI-MS), UV spectral analyses and by comparison with literature data. The cytotoxic activity of three isolated compounds (1-3) was evaluated against fibrosarcoma (HT1080), human lung cancer (A549) and breast cancer (MCF7) cell lines...
September 25, 2017: Natural Product Research
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