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https://www.readbyqxmd.com/read/28087102/feature-selection-for-outcome-prediction-in-oesophageal-cancer-using-genetic-algorithm-and-random-forest-classifier
#1
Desbordes Paul, Ruan Su, Modzelewski Romain, Vauclin Sébastien, Vera Pierre, Gardin Isabelle
The outcome prediction of patients can greatly help to personalize cancer treatment. A large amount of quantitative features (clinical exams, imaging, …) are potentially useful to assess the patient outcome. The challenge is to choose the most predictive subset of features. In this paper, we propose a new feature selection strategy called GARF (genetic algorithm based on random forest) extracted from positron emission tomography (PET) images and clinical data. The most relevant features, predictive of the therapeutic response or which are prognoses of the patient survival 3 years after the end of treatment, were selected using GARF on a cohort of 65 patients with a local advanced oesophageal cancer eligible for chemo-radiation therapy...
December 28, 2016: Computerized Medical Imaging and Graphics: the Official Journal of the Computerized Medical Imaging Society
https://www.readbyqxmd.com/read/28078109/prognostic-impact-of-tumour-associated-b-cells-and-plasma-cells-in-oesophageal-and-gastric-adenocarcinoma
#2
Richard Fristedt, David Borg, Charlotta Hedner, Jonna Berntsson, Björn Nodin, Jakob Eberhard, Patrick Micke, Karin Jirström
BACKGROUND: While it is well established that the cell-mediated immune response plays an important role in cancer progression and spread, the role of the humoral immune response in this regard has been less studied. According to the existing literature, dense infiltration of B cells or plasma cells appears to correlate mainly with an improved prognosis in several types of cancer, but their prognostic impact in oesophageal and gastric cancer has not yet been described. METHODS: Immunohistochemistry was applied on tissue microarrays (TMA) to assess the stromal density of B cells (CD20+) and plasma cells [CD138+ or immunoglobulin kappa C (IGKC+)] in chemo-/radiotherapy-naive tumours from a consecutive cohort of 174 patients with resected oesophageal or gastric adenocarcinoma...
December 2016: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/28072768/effect-of-low-dose-aspirin-use-on-survival-of-patients-with-gastrointestinal-malignancies-an-observational-study
#3
M A Frouws, E Bastiaannet, R E Langley, W K Chia, M P P van Herk-Sukel, V E P P Lemmens, H Putter, H H Hartgrink, B A Bonsing, C J H Van de Velde, J E A Portielje, G J Liefers
BACKGROUND: Previous studies suggested a relationship between aspirin use and mortality reduction. The mechanism for the effect of aspirin on cancer outcomes remains unclear. The aim of this study was to evaluate aspirin use and survival in patients with gastrointestinal tract cancer. METHODS: Patients with gastrointestinal tract cancer diagnosed between 1998 and 2011 were included. The population-based Eindhoven Cancer Registry was linked to drug-dispensing data from the PHARMO Database Network...
January 10, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28072456/systemic-inflammatory-markers-and-outcome-in-patients-with-locally-advanced-adenocarcinoma-of-the-oesophagus-and-gastro-oesophageal-junction
#4
V P Jagadesham, S M Lagarde, A Immanuel, S M Griffin
BACKGROUND: Raised levels of systemic inflammatory markers are associated with poor survival in patients with cancer. The aim of this study was to assess the prognostic value of markers of systemic inflammation in patients with adenocarcinoma of the oesophagus or gastro-oesophageal junction. METHODS: Data from a consecutive series of patients undergoing transthoracic oesophagectomy following neoadjuvant therapy at a single centre were analysed. Fibrinogen, albumin, C-reactive protein, leucocyte differential and platelet counts were measured before surgery...
January 10, 2017: British Journal of Surgery
https://www.readbyqxmd.com/read/28062432/epirubicin-extravasation-consequences-of-delayed-management
#5
Olivia Hale, Peter George Deutsch, Anindya Lahiri
Epirubicin is an anthracycline chemotherapy agent used for treatment of several cancers including oesophageal, breast and gastric. Extravasation is a well-recognised and serious complication of any intravenous therapies but especially chemotherapeutic agents. Signs of the injury can be subtle and without prompt recognition and treatment there can be extensive tissue damage and depending on location of injury this can result in significant functional loss. In this article, a case of delayed management of epirubicin extravasation from a cannula situated at the dorsum of the hand is discussed...
January 6, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28058012/evolving-management-of-metaplasia-and-dysplasia-in-barrett-s-epithelium
#6
REVIEW
Richard P T Evans, Moustafa Mabrouk Mourad, Simon G Fisher, Simon R Bramhall
Oesophageal cancer affects more than 450000 people worldwide and despite continued medical advancements the incidence of oesophageal cancer is increasing. Oesophageal cancer has a 5 year survival of 15%-25% and now globally attempts are made to more aggressively diagnose and treat Barrett's oesophagus the known precursor to invasive disease. Currently diagnosis the of Barrett's oesophagus is predominantly made after endoscopic visualisation and histopathological confirmation. Minimally invasive techniques are being developed to improve the viability of screening programs...
December 21, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28053055/cancer-incidence-and-mortality-risks-in-a-large-us-barrett-s-oesophagus-cohort
#7
Michael B Cook, Sally B Coburn, Jameson R Lam, Philip R Taylor, Jennifer L Schneider, Douglas A Corley
OBJECTIVE: Barrett's oesophagus (BE) increases the risk of oesophageal adenocarcinoma by 10-55 times that of the general population, but no community-based cancer-specific incidence and cause-specific mortality risk estimates exist for large cohorts in the USA. DESIGN: Within Kaiser Permanente Northern California (KPNC), we identified patients with BE diagnosed during 1995-2012. KPNC cancer registry and mortality files were used to estimate standardised incidence ratios (SIR), standardised mortality ratios (SMR) and excess absolute risks...
January 4, 2017: Gut
https://www.readbyqxmd.com/read/28052061/integrated-genomic-characterization-of-oesophageal-carcinoma
#8
(no author information available yet)
Oesophageal cancers are prominent worldwide; however, there are few targeted therapies and survival rates for these cancers remain dismal. Here we performed a comprehensive molecular analysis of 164 carcinomas of the oesophagus derived from Western and Eastern populations. Beyond known histopathological and epidemiologic distinctions, molecular features differentiated oesophageal squamous cell carcinomas from oesophageal adenocarcinomas. Oesophageal squamous cell carcinomas resembled squamous carcinomas of other organs more than they did oesophageal adenocarcinomas...
January 4, 2017: Nature
https://www.readbyqxmd.com/read/28049126/comorbidities-in-interstitial-lung-diseases
#9
REVIEW
George A Margaritopoulos, Katerina M Antoniou, Athol U Wells
Fibrosing lung disorders include a large number of diseases with diverse behaviour. Patients can die because of the progression of their illness, remain stable or even improve after appropriate treatment has been instituted. Comorbidities, such as acute and chronic infection, gastro-oesophageal reflux, pulmonary hypertension, lung cancer, cardiovascular diseases, and obstructive sleep apnoea, can pre-exist or develop at any time during the course of the disease and, if unidentified and untreated, may impair quality of life, impact upon the respiratory status of the patients, and ultimately lead to disease progression and death...
January 2017: European Respiratory Review: An Official Journal of the European Respiratory Society
https://www.readbyqxmd.com/read/28040757/surgery-for-malignant-pulmonary-nodules-in-patients-with-a-history-of-oesophageal-cancer
#10
Ryu Kanzaki, Toru Kimura, Tomohiro Kawamura, Soichiro Funaki, Yasushi Shintani, Masato Minami, Makoto Yamasaki, Masaki Mori, Yuichiro Doki, Meinoshin Okumura
OBJECTIVES: The objective of this study is to analyse the short- and long-term results of surgery for malignant pulmonary nodules in patients with a history of oesophageal cancer (EC) in order to assess the significance of surgery in these patients. METHODS: The data of 28 consecutive patients with a history of EC who underwent pulmonary resection for malignant pulmonary nodules were reviewed. The perioperative and long-term results were analysed. RESULTS: The histological type of oesophageal cancer was squamous cell carcinoma in all of the patients...
December 31, 2016: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/28035969/the-neurobiological-impact-of-ghrelin-suppression-after-oesophagectomy
#11
REVIEW
Conor F Murphy, Carel W le Roux
Ghrelin, discovered in 1999, is a 28-amino-acid hormone, best recognized as a stimulator of growth hormone secretion, but with pleiotropic functions in the area of energy homeostasis, such as appetite stimulation and energy expenditure regulation. As the intrinsic ligand of the growth hormone secretagogue receptor (GHS-R), ghrelin appears to have a broad array of effects, but its primary role is still an area of debate. Produced mainly from oxyntic glands in the stomach, but with a multitude of extra-metabolic roles, ghrelin is implicated in complex neurobiological processes...
December 26, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28028809/geridonin-a-novel-derivative-of-oridonin-inhibits-proliferation-of-mgc-803-cells-both-in-vitro-and-in-vivo-through-elevating-the-intracellular-ros
#12
Sai-Qi Wang, Cong Wang, Jun-Wei Wang, Dong-Xiao Yang, Ran Wang, Chuan-Jin Wang, Hui-Ju Li, Hong-Ge Shi, Yu Ke, Hong-Min Liu
OBJECTIVES: To study the antitumour activity of a novel derivative of oridonin named geridonin in vitro and in vivo. METHODS: MTT and colony formation assay were used to test the cytotoxicity of geridonin; apoptosis, cell cycle arrest and the levels of reactive oxygen species were measured by flow cytometry; JC-1 staining assay was used to examine the mitochondrial membrane potential; the MGC 803 xenograft model was established to evaluate the antitumour effect of geridonin in vivo; H&E staining was performed for the histological analysis...
December 28, 2016: Journal of Pharmacy and Pharmacology
https://www.readbyqxmd.com/read/28024799/assessment-of-older-patients-with-cancer-edmonton-frail-scale-efs-as-a-predictor-of-adverse-outcomes-in-older-patients-undergoing-radiotherapy
#13
Lorna G Keenan, Michelle O'Brien, Tim Ryan, Mary Dunne, Orla McArdle
OBJECTIVE: In this study we evaluate the usefulness of the Edmonton Frail Scale (EFS) in predicting which older patients are at risk of developing serious toxicities during radiotherapy. MATERIALS AND METHODS: This prospective study was carried out over an 18month period. Our primary aim was to examine the Edmonton Frail Scale (EFS) as a predictor of toxicity in patients over 70years undergoing radical radiotherapy for any malignant diagnosis. RESULTS: 63 patients were recruited: 29% experienced grade 3 or greater toxicities, with very few having multiple grade 3 or greater toxicities...
December 23, 2016: Journal of Geriatric Oncology
https://www.readbyqxmd.com/read/28011472/kif11-is-required-for-spheroid-formation-by-oesophageal-and-colorectal-cancer-cells
#14
Takeharu Imai, Naohide Oue, Kazuhiro Sentani, Naoya Sakamoto, Naohiro Uraoka, Hiroyuki Egi, Takao Hinoi, Hideki Ohdan, Kazuhiro Yoshida, Wataru Yasui
BACKGROUND: Oesophageal squamous cell carcinoma (ESCC) and colorectal cancer (CRC) are common types of human cancer. Spheroid colony formation is used to characterize cancer stem cell (CSCs). In the present study, we analyzed the significance of kinesin family 11 (KIF11 in human ESCC and CRC. MATERIALS AND METHODS: Expression of KIF11 in 105 ESCC and 100 CRC cases was determined using immunohistochemistry. RNA interference was used to inhibit KIF11 expression in ESCC and CRC cell lines...
January 2017: Anticancer Research
https://www.readbyqxmd.com/read/28008773/radiotherapy-response-evaluation-using-fdg-pet-ct-established-and-emerging-applications
#15
Helen Cliffe, Chirag Patel, Robin Prestwich, Andrew Scarsbrook
Radiation therapy is a common component of curative cancer treatment. However, there is a significant incidence of treatment failure. In these cases salvage surgical options are sometimes appropriate. Accurate assessment of response and early recognition of treatment success or failure is therefore critical to guide treatment decisions and impacts on survival and the morbidity of treatment. Traditionally, treatment response has depended upon anatomical measurement of disease. However, this may not correlate well with the presence of disease, especially after radiotherapy...
December 23, 2016: British Journal of Radiology
https://www.readbyqxmd.com/read/28008704/effect-of-nursing-care-given-at-home-on-the-quality-of-life-of-patients-with-stomach-cancer-and-their-family-caregivers-nursing-care
#16
S Bilgin, S Gozum
In Turkey, the high incidences of stomach and oesophageal cancers in East and high incidence of stomach cancer in Northeast regions are remarkable. This study was conducted to identify homecare needs of patients with stomach cancer and their caregivers and the effect of family supportive nursing care on the quality of life of patients and families. The patient and his/her caregiver were assessed with respect to their daily life activities and NANDA was used for the identified nursing diagnoses, NIC for the appropriate interventions and NOC for assessment of the results...
December 22, 2016: European Journal of Cancer Care
https://www.readbyqxmd.com/read/27992375/improved-method-for-prioritization-of-disease-associated-lncrnas-based-on-cerna-theory-and-functional-genomics-data
#17
Peng Wang, Qiuyan Guo, Yue Gao, Hui Zhi, Yan Zhang, Yue Liu, Jizhou Zhang, Ming Yue, Maoni Guo, Shangwei Ning, Guangmei Zhang, Xia Li
Although several computational models that predict disease-associated lncRNAs (long non-coding RNAs) exist, only a limited number of disease-associated lncRNAs are known. In this study, we mapped lncRNAs to their functional genomics context using competing endogenous RNAs (ceRNAs) theory. Based on the criteria that similar lncRNAs are likely involved in similar diseases, we proposed a disease lncRNA prioritization method, DisLncPri, to identify novel disease-lncRNA associations. Using a leave-one-out cross validation (LOOCV) strategy, DisLncPri achieved reliable area under curve (AUC) values of 0...
December 15, 2016: Oncotarget
https://www.readbyqxmd.com/read/27968855/improvement-of-cancer-control-in-mainland-china-epidemiological-profiles-during-the-2004-10-national-cancer-prevention-and-control-program
#18
Xin-Zu Chen, Yang Liu, Rui Wang, Wei-Han Zhang, Jian-Kun Hu
BACKGROUND: Following the appeal of the World Health Assembly for national cancer plans and programmes, the Chinese Ministry of Health issued governmental outlines of the National Cancer Prevention and Control Programme (2004-10). This study aimed to evaluate the efficacy of that programme in mainland China. METHODS: The Chinese Ministry of Health outlines aimed to establish a national cancer registry system, enhance the population health education, and organise prevention, early detection, and early treatment for principal cancers, especially in rural areas for high-incidence cancers...
October 2016: Lancet
https://www.readbyqxmd.com/read/27968842/quality-of-life-and-health-utility-scores-for-common-cancers-in-china-a-multicentre-cross-sectional-survey
#19
Ju-Fang Shi, Hui-Yao Huang, Lan-Wei Guo, Dian Shi, Xiu-Ying Gu, Han Liang, Le Wang, Jian-Song Ren, Ya-Na Bai, A-Yan Mao, Guo-Xiang Liu, Xian-Zhen Liao, Kai Zhang, Jie He, Min Dai
BACKGROUND: The measurement of quality-adjusted life-years (QALYs) forms a key component of cost-utility evaluation in cancer intervention; however, detailed data for utility weights by cancer type and health status are still scarce both in China and other regions. The aim of this study was to systematically evaluate utility scores in relation to the most common six cancers in China in 2012 (lung, breast, colorectal, oesophageal, liver, and stomach cancer). METHODS: As a part of a Screening Program in Urban China (CanSPUC) supported by the central government of China, we undertook a cross-sectional survey in 13 provinces across China from 2013 to 2014...
October 2016: Lancet
https://www.readbyqxmd.com/read/27968822/expenditure-and-financial-burden-for-common-cancers-in-china-a-hospital-based-multicentre-cross-sectional-study
#20
Hui-Yao Huang, Ju-Fang Shi, Lan-Wei Guo, Xin-Yu Zhu, Le Wang, Xian-Zhen Liao, Guo-Xiang Liu, Ya-Na Bai, A-Yan Mao, Jian-Song Ren, Xiao-Jie Sun, Kai Zhang, Jie He, Min Dai
BACKGROUND: Comprehensive health economic evaluation, a key component of the Cancer Screening Program in Urban China (CanSPUC), was expected to support government policy-making on screening initiatives for common cancers (lung, breast, colorectal, oesophageal, liver, and stomach cancer) in urban China. Estimation of expenditure for cancer diagnosis and treatment from a societal perspective was an essential component. The aim of this study was to estimate direct medical and non-medical expenditure and to discern the resultant financial burden...
October 2016: Lancet
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