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https://www.readbyqxmd.com/read/29221240/composite-metrics-in-response-assessment-new-hope-in-oesophageal-cancer
#1
EDITORIAL
Janusz Włodarczyk, Jarosław Kużdżał
No abstract text is available yet for this article.
September 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29221227/pet-guided-treatment-algorithms-in-oesophageal-cancer-the-promise-of-the-near-future
#2
EDITORIAL
Lioe-Fee de Geus-Oei, Marije Slingerland
No abstract text is available yet for this article.
September 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29221150/comparison-of-gross-tumor-volume-of-primary-oesophageal-cancer-based-on-contrast-enhanced-three-dimensional-four-dimensional-and-cone-beam-computed-tomography
#3
Chao-Yue Hu, Jian-Bin Li, Jin-Zhi Wang, Wei Wang, Feng-Xiang Li, Yan-Luan Guo
Background: To explore motion information included in 3DCT, 4DCT and CBCT by comparing volumetric and positional differences of GTV. Results: Independent of tumor location, significant differences were observed among volumes [IGTV10 > (IGTVCBCT or IGTVMIP) > (GTV3D or GTV4D50)]. The underestimations or overestimations between IGTV10 and IGTVCBCT were larger than those between IGTV10 and IGTVMIP (p < 0.001-0.011; p < 0.001-0.023). For upper oesophageal tumors, GTV4D50/IGTVCBCT negatively correlated with motion vector (r = -0...
November 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/29218619/cervical-ultrasonography-has-no-additional-value-over-negative-18f-fdg-pet-ct-scans-for-diagnosing-cervical-lymph-node-metastases-in-patients-with-oesophageal-cancer
#4
Lucas Goense, Jihane Meziani, Peter S N van Rossum, Frank J Wessels, Marnix G E H Lam, Richard van Hillegersberg, Jelle P Ruurda
OBJECTIVES: To investigate the additional value of cervical ultrasonography over 18F-FDG PET/CT for diagnosing cervical lymph node metastases in patients with newly diagnosed oesophageal cancer. METHODS: Between January 2013 and January 2016, 163 patients with newly diagnosed oesophageal cancer underwent both cervical ultrasonography and 18F-FDG PET/CT at a tertiary referral centre in the Netherlands. Retrospective clinical data analysis was performed to assess the diagnostic value of cervical ultrasonography and 18F-FDG PET/CT for the detection of cervical lymph node metastases...
December 7, 2017: European Radiology
https://www.readbyqxmd.com/read/29216650/-have-multimodal-and-perioperative-therapeutic-strategies-changed-the-survival-after-oncological-oesophageal-surgery-in-the-last-two-decades-a-retrospective-cohort-analysis-over-23-years
#5
Philipp Lingohr, Julia Zender, Cornelius van Beekum, Jonas Dohmen, Hanno Matthaei, Nico Schaefer, Jörg C Kalff, Tim Oliver Vilz
Background Esophageal malignoma is among the most frequent causes for cancer-related deaths. The only definite curative therapy is esophagectomy embedded in various multimodal treatment regimens. The aim of this study was to evaluate long-term development after esophageal surgery in the last two decades in order to observe possible trends and their influence on short, medium and long term survival. Patients and Methods Cases of 301 patients who underwent esophagectomy between 1989 and 2012 were analysed retrospectively...
December 7, 2017: Zentralblatt Für Chirurgie
https://www.readbyqxmd.com/read/29216556/influence-of-water-activity-and-temperature-on-growth-and-fumonisin-production-by-fusarium-proliferatum-strains-on-irradiated-wheat-grains
#6
Eugenia Cendoya, María Del Pilar Monge, Stella Maris Chiacchiera, María Cecilia Farnochi, María Laura Ramirez
Wheat is the most important cereal consumed by the Argentine population. In previous studies performed in durum and common wheat grains in this country it has been observed fumonisin contamination as well as high incidence of Fusarium proliferatum. Fumonisins are toxic fungal metabolites, and consumption of fumonisin-contaminated maize has been epidemiologically associated with oesophageal cancer and neural tube defects in some human populations. Using irradiated wheat-grains, the effects of abiotic factors, temperature (15, 25, and 30°C) and water activity (aW; 0...
December 4, 2017: International Journal of Food Microbiology
https://www.readbyqxmd.com/read/29212656/the-relevance-and-implications-of-signet-ring-cell-adenocarcinoma-of-the-oesophagus
#7
REVIEW
Christopher William Bleaney, Mickhaiel Barrow, Stephen Hayes, Yeng Ang
AIM: To review the current understanding of signet-ring type oesophageal adenocarcinoma including evidence for prognosis. METHODS: We conducted a literature search of nine healthcare literature databases for articles detailing the biology and clinical outcomes of signet-ring cell adenocarcinoma of the oesophagus. The impact of signet-ring cell morphology was analysed and detailed in written text and tabular format. Current understanding of the biology of signet-ring cell adenocarcinoma of the oesophagus was summarised...
December 6, 2017: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/29211685/optimisation-of-sampling-parameters-for-standardised-exhaled-breath-sampling
#8
Sophie L F Doran, Andrea Romano, George B Hanna
The lack of standardisation of breath sampling is a major contributing factor to the poor repeatability of results and hence represents a barrier to the adoption of breath tests in clinical practice. On-line and bag breath sampling have advantages but do not suit multicentre clinical studies whereas storage and robust transport are essential for the conduct of wide-scale studies. Several devices have been developed to control sampling parameters and to concentrate volatile organic compounds (VOCs) onto thermal desorption (TD) tubes and subsequently transport those tubes for laboratory analysis...
December 6, 2017: Journal of Breath Research
https://www.readbyqxmd.com/read/29209536/activating-her2-mutations-as-emerging-targets-in-multiple-solid-cancers
#9
REVIEW
Claire M Connell, Gary J Doherty
The epidermal growth factor receptor (EGFR) family of transmembrane receptor tyrosine kinases activates signalling pathways regulating cellular proliferation and survival. HER2 is a non-ligand-binding member of this family and exerts its activity through heterodimerisation with other EGFR family members. HER2 functional activation promotes oncogenesis, leading to the investigation of HER2-directed agents in cancers with HER2 alterations. This has been best characterised in the context of HER2 gene amplification in breast and gastro-oesophageal cancers, for which HER2-directed drugs form part of standard treatment regimens...
2017: ESMO Open
https://www.readbyqxmd.com/read/29208442/defining-a-global-research-and-policy-agenda-for-betel-quid-and-areca-nut
#10
REVIEW
Hedieh Mehrtash, Kalina Duncan, Mark Parascandola, Annette David, Ellen R Gritz, Prakash C Gupta, Ravi Mehrotra, Amer Siddiq Amer Nordin, Paul C Pearlman, Saman Warnakulasuriya, Chi-Pang Wen, Rosnah Binti Zain, Edward L Trimble
Betel quid and areca nut are known risk factors for many oral and oesophageal cancers, and their use is highly prevalent in the Asia-Pacific region. Additionally, betel quid and areca nut are associated with health effects on the cardiovascular, nervous, gastrointestinal, metabolic, respiratory, and reproductive systems. Unlike tobacco, for which the WHO Framework Convention on Tobacco Control provides evidence-based policies for reducing tobacco use, no global policy exists for the control of betel quid and areca nut use...
December 2017: Lancet Oncology
https://www.readbyqxmd.com/read/29207170/bmi-1-suppression-increases-the-radiosensitivity-of-oesophageal-carcinoma-via-the-pi3k-akt-signaling-pathway
#11
Xing-Xiao Yang, Ming Ma, Mei-Xiang Sang, Xue-Yuan Zhang, Zhi-Kun Liu, Heng Song, Shu-Chai Zhu
B-cell‑specific Moloney murine leukaemia virus integration site-1 (BMI-1) contributes to the growth of tumour cells post-irradiation (IR). The aim of the present study was to characterize the effects of BMI-1 on cell viability, radiosensitivity and its mechanisms of action in oesophageal squamous cell cancer (ESCC). Western blotting and immunohistochemistry were employed to evaluate the protein expression of BMI-1 in ESCC cells and specimens, respectively. Additionally, the protein expression levels of BMI-1, H2AK119ub and γH2AX in ESCC cells were detected following different doses of IR and at different times after IR...
December 5, 2017: Oncology Reports
https://www.readbyqxmd.com/read/29204834/oesophageal-stem-cells-and-cancer
#12
Maria P Alcolea
Oesophageal cancer remains one of the least explored malignancies. However, in recent years its increasing incidence and poor prognosis have stimulated interest from the cancer community to understand the pathways to the initiation and progression of the disease.Critical understanding of the molecular processes controlling changes in stem cell fate and the cross-talk with their adjacent stromal neighbours will provide essential knowledge on the mechanisms that go awry in oesophageal carcinogenesis. Advances in lineage tracing techniques have represented a powerful tool to start understanding changes in oesophageal cell behaviour in response to mutations and mutagens that favour tumour development...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29203054/on-the-search-to-elucidate-the-role-of-the-microbiota-in-the-genesis-of-cancer-the-cases-of-gastrointestinal-and-cervical-cancer
#13
REVIEW
Francisco Avilés-Jiménez, Yu Guogin, Kirvis Torres-Poveda, Vicente Madrid-Marina, Javier Torres
The microbiota that inhabits the human body plays an important role in health and disease, by their fundamental role in food digestion, training of the immune system or protection against pathogen colonization. However, when the equilibrium with its host is altered, some diseases like cancer might be promoted. In this review we describe the information collected in recent studies between the microbiota and its association with cancer. We conducted the review of the relation of microbiome and cancer etiology focusing on the gastrointestinal and cervical cancer...
December 1, 2017: Archives of Medical Research
https://www.readbyqxmd.com/read/29197960/sarcopenia-during-neoadjuvant-therapy-for-oesophageal-cancer-characterising-the-impact-on-muscle-strength-and-physical-performance
#14
Emer M Guinan, S L Doyle, A E Bennett, L O'Neill, J Gannon, J A Elliott, J O'Sullivan, J V Reynolds, J Hussey
PURPOSE: Preoperative chemo(radio)therapy for oesophageal cancer (OC) may have an attritional impact on body composition and functional status, impacting postoperative outcome. Physical decline with skeletal muscle loss has not been previously characterised in OC and may be amenable to physical rehabilitation. This study characterises skeletal muscle mass and physical performance from diagnosis to post-neoadjuvant therapy in patients undergoing preoperative chemo(radio)therapy for OC...
December 2, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/29195677/do-smoking-and-alcohol-behaviours-influence-gi-cancer-survival
#15
REVIEW
Úna C McMenamin, Stephen McCain, Andrew T Kunzmann
Little is known about the role of alcohol and smoking in GI cancer survival compared to GI cancer development. We systematically reviewed the evidence for a role of smoking and alcohol in prognosis among GI cancer patients and inform whether smoking or alcohol cessation interventions or guidelines for GI cancer patients are likely to improve prognosis. A total of 84 relevant studies were identified. Continued smokers, particularly heavy smokers, had worse prognosis than never smokers in most GI cancers. However, more evidence is needed to establish the likely impact of smoking cessation interventions amongst GI cancer patients...
October 2017: Best Practice & Research. Clinical Gastroenterology
https://www.readbyqxmd.com/read/29195670/alcohol-smoking-and-risk-of-oesophago-gastric-cancer
#16
REVIEW
Jing Dong, Aaron P Thrift
Oesophago-gastric cancers (oesophageal and gastric cancers) are common, highly fatal cancers. Oesophageal squamous cell carcinoma (OSCC) and oesophageal adenocarcinoma (OAC) are the two main histological subtypes of oesophageal cancer. Globally, OSCC remains the most common histological subtype of oesophageal cancer, with the highest burden occurring along two geographic belts, one from north central China through the central Asian republics to northern Iran, and one from eastern to southern Africa. In Western countries, the incidence of OAC has increased dramatically over the past 40 years...
October 2017: Best Practice & Research. Clinical Gastroenterology
https://www.readbyqxmd.com/read/29189391/blood-biomarkers-for-early-diagnosis-of-oesophageal-cancer-a-systematic-review
#17
Andrew T Kunzmann, Úna C McMenamin, Andrew D Spence, Ronan T Gray, Liam J Murray, Richard C Turkington, Helen G Coleman
BACKGROUND: Oesophageal cancer prognosis remains poor owing to the inability to detect the disease at an early stage. Nontissue (serum, urinary or salivary) biomarkers potentially offer less invasive methods to aid early detection of oesophageal cancer. We aimed to systematically review studies assessing the relationship between nontissue biomarkers and subsequent development of oesophageal cancer. METHODS: Using terms for biomarkers and oesophageal cancer, Medline, EMBASE and Web of Science were systematically searched for longitudinal studies, published until April 2016, which assessed the association between nontissue biomarkers and subsequent oesophageal cancer risk...
November 17, 2017: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29179134/a-randomised-phase-ii-study-of-chemoradiotherapy-with-or-without-nimotuzumab-in-locally-advanced-oesophageal-cancer-nice-trial
#18
Gilberto de Castro Junior, José Getúlio Segalla, Sérgio Jobim de Azevedo, Carlos José Andrade, Daniel Grabarz, Bruno de Araújo Lima França, Auro Del Giglio, Nicolas Silva Lazaretti, Maria Nunes Álvares, José Luiz Pedrini, Celio Kussumoto, João Nunes de Matos Neto, Nora Manoukian Forones, Hezio Jadir Fernandes Júnior, Giuliano Borges, Gustavo Girotto, Ismael Dale Cotrim Guerreiro da Silva, Fauze Maluf-Filho, Nils Gunnar Skare
PURPOSE: Chemoradiotherapy is the standard treatment for patients with inoperable locally advanced oesophageal cancer. We sought to assess the safety and efficacy of chemoradiation combined with nimotuzumab, a humanised antibody directed against epidermal growth factor receptor (EGFR). PATIENTS AND METHODS: Untreated patients with inoperable locally advanced oesophageal cancer and no distant metastases were randomised to chemoradiotherapy (cisplatin and fluorouracil combined with external beam radiation) alone or in combination with nimotuzumab...
November 24, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/29177502/prognostic-value-of-lymph-node-count-on-survival-in-pathologically-node-negative-oesophageal-squamous-cell-cancer
#19
Yue Yu, Wei Wang, Qing Li, Fei Zhao, Yue Zhou, Jing Xu, Chenjun Huang
OBJECTIVES: This study aims to determine whether lymph node (LN) count is an independent predictor of survival in patients with pathologically node-negative (pN0) oesophageal squamous cell carcinoma (OSCC). METHODS: Retrospective analysis was performed on 194 pN0 OSCC patients undergoing radical oesophagectomy between January 2004 and December 2008. The association between the LN count and survival was assessed using the Cox proportional hazard model. The optimal LN count cut-off values were determined using the X-tile program...
November 21, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/29177066/non-acid-gastro-oesophageal-reflux-is-associated-with-squamous-cell-carcinoma-of-the-oesophagus
#20
Mpho Kgomo, Taole R Mokoena, James A Ker
Introduction: Squamous cell carcinoma of the oesophagus is a common cancer among South Africans. Due to the absence of effective screening and surveillance programme for early detection and late presentation, squamous cell carcinoma of the oesophagus is usually diagnosed at an advanced stage or when metastasis has already occurred. The 5-year survival is often quoted at 5%-10%, which is poor. Objectives: To determine the association between oesophageal squamous cell carcinoma (OSCC) and non-acid gastro-oesophageal reflux disease...
2017: BMJ Open Gastroenterology
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