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oesophage cancer

Dimitra P Vageli, Sotirios G Doukas, Todd Spock, Clarence T Sasaki
The presence of bile is not an uncommon finding in acidic oesophageal and extra-oesophageal refluxate, possibly affecting the hypopharyngeal mucosa and leading to neoplastic events. We recently demonstrated that acidic bile (pH ≤ 4.0) can induce NF-κB activation and oncogenic mRNA phenotype in normal hypopharyngeal cells and generate premalignant changes in treated hypopharyngeal mucosa. We hypothesize that curcumin, a dietary inhibitor of NF-κB, may effectively inhibit the acidic bile-induced cancer-related mRNA phenotype, in treated human hypopharyngeal primary cells (HHPC), supporting its potential preventive use in vivo...
June 17, 2018: Journal of Cellular and Molecular Medicine
Corinne N Johnson, Gareth J Price, Corinne Faivre-Finn, Marianne C Aznar, Marcel van Herk
BACKGROUND: and Purpose: Image-guided radiotherapy (IGRT) is widely used but data directly relating setup errors to patient outcome is scarce. This study investigates the relationship between residual IGRT shifts and overall patient survival, and uses the observed relations to identify structures sensitive to radiation dose. MATERIALS AND METHODS: Residual shift data for 780 NSCLC patients was summarised for each patient over the course of treatment by determining the mean shifts, standard deviations and the vector shift in the direction of the heart...
June 1, 2018: International Journal of Radiation Oncology, Biology, Physics
Huaying Zhao, Changying Diao, Xiaohui Wang, Yilin Xie, Yaqing Liu, Xianzheng Gao, Jing Han, Shenglei Li
This study was aimed at exploring the effect of lncRNA BDNF-AS on cell proliferation, migration, invasion and epithelial-to-mesenchymal transition (EMT) of oesophageal cancer (EC) cells. The expression of BDNF-AS and miR-214 in tissue samples and cells was measured by qRT-PCR. The targeted relationship between BDNF-AS and miR-214 was analysed by dual-luciferase reporter assay. After cell transfection, the cell proliferation activity was assessed by MTS method, while the migrating and invading abilities were evaluated by transwell assay...
June 12, 2018: Journal of Cellular and Molecular Medicine
Katie E O' Sullivan, Adriana J Michielsen, Esther O' Regan, Mary C Cathcart, Gillian Moore, Eamon Breen, Ricardo Segurado, John V Reynolds, Joanne Lysaght, Jacintha O' Sullivan
Signal transducers and activator of transcription (STAT)-3 is activated in cancers, where it promotes growth, inflammation, angiogenesis, and inhibits apoptosis. Tissue microarrays were generated using tissues from 154 patients, with oesophageal adenocarcinoma (OAC) ( n = 116) or squamous cell carcinoma (SCC) ( n = 38) tumours. The tissues were stained for pSTAT3 and IL-6R using immunohistochemistry. The OE33 (OAC) and OE21 (SCC) cell lines were treated with the STAT3 inhibitor, STATTIC. The Univariate cox regression analysis revealed that a positive pSTAT3 in SCC was adversely associated with survival (Hazard ratio (HR) 6...
June 10, 2018: International Journal of Molecular Sciences
Harry Kaltsidis, Wasat Mansoor, Jung-Hoon Park, Ho-Young Song, Derek William Edwards, Hans-Ulrich Laasch
Oesophageal stents are widely used for palliating dysphagia from malignant obstruction. They are also used with increasing frequency in the treatment of oesophageal perforation, as well as benign strictures from a variety of causes. Improved oncological treatments have led to prolonged survival of patients treated with palliative intent; as a consequence, stents need to function and last longer in order to avoid repeat procedures. There is also increasing need for meticulous procedure planning, careful selection of the device most appropriate for the individual patient and planned follow-up...
June 11, 2018: British Journal of Radiology
Edith Lahner, Marina Capasso, Marilia Carabotti, Bruno Annibale
BACKGROUND: Pernicious anaemia (PA) is associated with increased gastric cancer risk, but the evidence is conflicting regarding the associated risk of other cancers. AIM: To systematically determine the incidence rates of gastro-intestinal cancers other than gastric cancers (GI-other-than-GC) and non-gastrointestinal cancers (non-GIC) in PA adults, globally and per tumour site, and the risk associated with PA for GI-other than GC and non-GIC. METHODS: Studies of PA patients reporting the incidence of GI-other-than-GCs and non-GICs were identified with MEDLINE (PubMed)-EMBASE (from first date available to April 2017)...
May 24, 2018: Digestive and Liver Disease
Ryohei Ono, Hidemitsu Ogino, Jun Kawachi, Rai Shimoyama, Hiroyuki Kashiwagi, Naoko Isogai, Katsunori Miyake, Ryuta Fukai, Takaaki Murata, Yuto Igarashi, Nobuaki Shinozaki
INTRODUCTION: Small intestinal metastasis from oesophageal carcinoma is rare. We report a case of small intestinal metastases from oesophageal carcinoma presenting as a perforation and discuss the aetiology with other cases of small intestinal metastasis from oesophageal carcinoma reported in previous literature. PRESENTATION: An 86-year-old man presented with fever and coughing. He had choked while eating and had history of weight loss. He was diagnosed with aspiration pneumonia...
June 5, 2018: International Journal of Surgery Case Reports
Thuy-My N Nguyen, Richard Hummel, Tim Bright, Sarah K Thompson, Bjorn Tornqvist, David I Watson
BACKGROUND: Most oesophageal outcome research focuses on surgical treatment, despite most patients not undergoing surgery as they are unfit or have metastatic disease. Few studies have evaluated the patterns of care for all patients presenting with oesophageal cancer. METHODS: All patients with oesophageal cancer, and high-grade dysplasia (HGD), presented at the South Australian state-wide upper gastrointestinal cancer multidisciplinary team from 2012 to 2015 were reviewed to determine the patterns of presentation and treatment...
June 9, 2018: ANZ Journal of Surgery
Ming Yu, Sean K Maden, Matthew Stachler, Andrew M Kaz, Jessica Ayers, Yuna Guo, Kelly T Carter, Amber Willbanks, Tai J Heinzerling, Rachele M O'Leary, Xinsen Xu, Adam Bass, Apoorva K Chandar, Amitabh Chak, Robin Elliott, Joseph E Willis, Sanford D Markowitz, William M Grady
OBJECTIVE: To identify and characterise DNA methylation subtypes in oesophageal adenocarcinoma (EAC) and its precursor Barrett's oesophagus (BE). DESIGN: We performed genome-wide DNA methylation profiling on samples of non-dysplastic BE from cancer-free patients (n=59), EAC (n=23), normal squamous oesophagus (n=33) and normal fundus (n=9), and identified methylation subtypes using a recursively partitioned mixture model. We assessed genomic alterations for 9 BE and 22 EAC samples with massively parallel sequencing of 243 EAC-associated genes, and we conducted integrative analyses with transcriptome data to identify epigenetically repressed genes...
June 8, 2018: Gut
Margreet van Putten, Brian T Johnston, Liam J Murray, Anna T Gavin, Damian T McManus, Shivaram Bhat, Richard C Turkington, Helen G Coleman
Background: A systematic review suggests that 25% of oesophageal adenocarcinomas (OAC) are 'missed' at index endoscopy for Barrett's oesophagus (BO); however, this included few population-based studies and may be an overestimate. Objective: The objective of this article is to quantify the 'missed' rates of high-grade dysplasia (HGD) and OAC at index BO endoscopy. Methods: Patients from the Northern Ireland BO register diagnosed between 1993 and 2010 ( n  = 13,159) were linked to the Northern Ireland Cancer Registry to identify patients who developed OAC or HGD...
May 2018: United European Gastroenterology Journal
Kohei Shitara, Mustafa Özgüroğlu, Yung-Jue Bang, Maria Di Bartolomeo, Mario Mandalà, Min-Hee Ryu, Lorenzo Fornaro, Tomasz Olesiński, Christian Caglevic, Hyun C Chung, Kei Muro, Eray Goekkurt, Wasat Mansoor, Raymond S McDermott, Einat Shacham-Shmueli, Xinqun Chen, Carlos Mayo, S Peter Kang, Atsushi Ohtsu, Charles S Fuchs
BACKGROUND: Patients with advanced gastric or gastro-oesophageal junction cancer that progresses on chemotherapy have poor outcomes. We compared pembrolizumab with paclitaxel in patients with advanced gastric or gastro-oesophageal junction cancer that progressed on first-line chemotherapy with a platinum and fluoropyrimidine. METHODS: This randomised, open-label, phase 3 study was done at 148 medical centres in 30 countries. Eligible patients were randomised (1:1) in blocks of four per stratum with an interactive voice-response and integrated web-response system to receive either pembrolizumab 200 mg every 3 weeks for up to 2 years or standard-dose paclitaxel...
June 4, 2018: Lancet
Stephanie Vitz, Holger Göbel, Bernhard Leibl, Thomas Aigner, Gerhard G Grabenbauer
PURPOSE: To retrospectively evaluate long-term treatment results following neoadjuvant chemoradiation (CRT) and radical surgery in patients with advanced adenocarcinoma (AC) of the oesophagus. PATIENTS AND METHODS: Between 2005 and 2015, a total of 102 consecutive patients with a median age of 64 years (range, 44-86 years) and AC of the oesophagus were evaluated of whom 84 received a full CRT. A group of 51 patients was treated with neoadjuvant intent followed by radical surgery...
June 5, 2018: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
Ronald Mbiine, Ronald Kabuye, Herve Monka Lekuya, William Manyillirah
BACKGROUND: Tuberculous (TB) oesophagitis is a rare manifestation of dysphagia occurring in 0.3% of all gastro-intestinal tract TB infections as well as 0.15% of all cases of dysphagia and often is misdiagnosed. This report presents a rare manifestation of TB as a cause of oesophageal stricture. CASE PRESENTATION: We describe a rare presentation of a patient with grade IV dysphagia due to an oesophageal stricture. Oesophagoscopy revealed a pinhole stricture with evidence of high grade dysplasia on histology...
June 5, 2018: Journal of Cardiothoracic Surgery
Philippe Bulens, Melissa Thomas, Christophe M Deroose, Karin Haustermans
Radiotherapy is the standard of care in the multimodality treatment of a variety of gastrointestinal (GI) tumours, such as oesophageal cancer, gastric cancer, rectal cancer and anal cancer. Additionally, radiotherapy has served as an alternative for surgery in patients with liver cancer, cancer of the biliary tract and pancreatic cancer. Positron-emission tomography (PET), generally in combination with computed tomography (CT), has an established role in the diagnosis, response assessment and (re-)staging of several GI tumours...
June 4, 2018: Quarterly Journal of Nuclear Medicine and Molecular Imaging
K G Foley, P Fielding, W G Lewis, S A Roberts
BACKGROUND: Lymph node metastases are a major prognostic indicator in oesophageal cancer. Radiological staging largely influences treatment decisions and is becoming more reliant on PET and CT. However, the sensitivity of these modalities is suboptimal and is known to under-stage disease. The primary aim of this study was to validate a published prognostic model in oesophageal cancer patients staged N0 with PET/CT, which showed that EUS nodal status was an independent predictor of survival...
June 4, 2018: Surgical Endoscopy
Rebecca C Fitzgerald
No abstract text is available yet for this article.
May 31, 2018: Lancet Oncology
Bo Jan Noordman, Manon C W Spaander, Roelf Valkema, Bas P L Wijnhoven, Mark I van Berge Henegouwen, Joël Shapiro, Katharina Biermann, Ate van der Gaast, Richard van Hillegersberg, Maarten C C M Hulshof, Kausilia K Krishnadath, Sjoerd M Lagarde, Grard A P Nieuwenhuijzen, Liekele E Oostenbrug, Peter D Siersema, Erik J Schoon, Meindert N Sosef, Ewout W Steyerberg, J Jan B van Lanschot
BACKGROUND: After neoadjuvant chemoradiotherapy for oesophageal cancer, roughly half of the patients with squamous cell carcinoma and a quarter of those with adenocarcinoma have a pathological complete response of the primary tumour before surgery. Thus, the necessity of standard oesophagectomy after neoadjuvant chemoradiotherapy should be reconsidered for patients who respond sufficiently to neoadjuvant treatment. In this study, we aimed to establish the accuracy of detection of residual disease after neoadjuvant chemoradiotherapy with different diagnostic approaches, and the optimal combination of diagnostic techniques for clinical response evaluations...
May 31, 2018: Lancet Oncology
Robert Munashe Maweni, Venughanan Manikavasagar, Nicholas Sunderland, Sajid Chaudhry
An 83-year-old woman, with a background of treated squamous cell oesophageal cancer, presented with a 3-week history of stridor. Of note, the patient had no risk factors for oesophageal cancer other than age. Clinical examination was unremarkable apart from stridor. Laboratory investigations, including arterial blood gas on room air, were unremarkable. Radiological examination revealed a 4.5×3.5×3.6 cm mass involving the posterior trachea and invading the tracheal orifice. Oesophagogastroduodenoscopy and rigid bronchoscopy confirmed an extensive tumour arising from the lower oesophagus and invading the trachea, causing 90% airway obstruction for a 6 mm length ending 1...
May 29, 2018: BMJ Case Reports
Lauren M Quinn, Alexander C Hollis, James Hodson, Mona A Elshafie, Mike T Hallissey, John L Whiting, Ewen A Griffiths
INTRODUCTION: The utility of Circumferential Resection Margin (CRM) status in predicting prognosis in oesophageal cancer is controversial, with different definitions used by the College of American Pathologists and the Royal College of Pathologists. We aimed to determine prognostic significance of CRM involvement and evaluate which system is the best predictor of prognosis. METHODS: A cohort of 390 patients who had potentially curative oesophagectomy (- + neoadjuvant chemotherapy) were analysed...
May 17, 2018: European Journal of Surgical Oncology
Martin R Gill, Jyothi U Menon, Paul J Jarman, Joshua Owen, Irini Skaripa-Koukelli, Sarah Able, Jim A Thomas, Robert Carlisle, Katherine A Vallis
Radiolabelled, drug-loaded nanoparticles may combine the theranostic properties of radionuclides, the controlled release of chemotherapy and cancer cell targeting. Here, we report the preparation of poly(lactic-co-glycolic acid) (PLGA) nanoparticles surface conjugated to DTPA-hEGF (DTPA = diethylenetriaminepentaacetic acid, hEGF = human epidermal growth factor) and encapsulating the ruthenium-based DNA replication inhibitor and radiosensitizer Ru(phen)2(tpphz)2+ (phen = 1,10-phenanthroline, tpphz = tetrapyridophenazine) Ru1...
June 7, 2018: Nanoscale
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