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https://www.readbyqxmd.com/read/28213876/update-on-neoadjuvant-regimens-for-patients-with-operable-oesophageal-gastrooesophageal-junction-adenocarcinomas-and-squamous-cell-carcinomas
#1
REVIEW
Samantha J Cox, Sean M O'Cathail, Bernadette Coles, Tom Crosby, Somnath Mukherjee
Survival outcomes following multimodal treatment of operable oesophageal and gastrooesophageal cancer remain disappointingly poor. Although an appreciation of the impact of both tumour location and histological subtype is now shaping the design of clinical trials, there has been a lack of consensus of the optimal neoadjuvant treatment strategy. This update article will review recent advances in the use of both neoadjuvant chemotherapy and chemoradiotherapy. The emerging role of PET imaging to direct appropriate neoadjuvant treatment regimens and the additive benefit of biological agents are also discussed...
January 2017: Current Oncology Reports
https://www.readbyqxmd.com/read/28196067/body-weight-trajectories-and-risk-of-oesophageal-and-gastric-cardia-adenocarcinomas-a-pooled-analysis-of-nih-aarp-and-plco-studies
#2
Jessica L Petrick, Scott P Kelly, Linda M Liao, Neal D Freedman, Barry I Graubard, Michael B Cook
BACKGROUND: Elevated body mass index (BMI, kg m(-2)) has been consistently associated with oesophageal adenocarcinoma (EA) and gastric cardia adenocarcinoma (GCA) incidence. However, effects of adiposity over the life course in relation to EA/GCA have not been thoroughly explored. METHODS: We pooled two prospective cohort studies: NIH-AARP Diet and Health Study and Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial, with data on 409 796 individuals (633 EA, 415 GCA)...
February 14, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28196063/long-term-results-and-recurrence-patterns-from-scope-1-a-phase-ii-iii-randomised-trial-of-definitive-chemoradiotherapy-cetuximab-in-oesophageal-cancer
#3
T Crosby, C N Hurt, S Falk, S Gollins, J Staffurth, R Ray, J A Bridgewater, J I Geh, D Cunningham, J Blazeby, R Roy, T Maughan, G Griffiths, S Mukherjee
BACKGROUND: The SCOPE-1 study tested the role of adding cetuximab to conventional definitive chemoradiotherapy (dCRT), and demonstrated greater toxicity and worse survival outcomes. We present the long-term outcomes and patterns of recurrence. METHODS: SCOPE-1 was a phase II/III trial in which patients were randomised to cisplatin 60 mg m(-2) (day 1) and capecitabine 625 mg m(-2) bd (days 1-21) for four cycles +/- cetuximab 400 mg m(-2) day 1 then by 250 mg m(-2) weekly...
February 14, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28188753/mir-498-in-oesophageal-squamous-cell-carcinoma-clinicopathological-impacts-and-functional-interactions
#4
Farhadul Islam, Vinod Gopalan, Simon Law, Johnny Cheuk-On Tang, Kwok-Wah Chan, Alfred King-Yin Lam
MicroRNA-498 plays a crucial role in progression of many carcinomas. The signalling pathways that miR-498 modulates carcinogenesis are still unknown. Also, miR-498 associated molecular pathogenesis has never been studied in the oesophageal squamous cell carcinoma (ESCC). Herein, we aimed to examine the expression and functional roles of miR-498 in the ESCC as well as its influences on the clinicopathological features in patients with ESCC. Expression of miR-498 was investigated in 93 ESCC tissues and five ESCC cell lines using quantitative real-time polymerase chain reaction...
February 8, 2017: Human Pathology
https://www.readbyqxmd.com/read/28188605/-cancer-and-mycoses-and-literature-review
#5
M Develoux
Various infectious agents are classical risk factors for cancer including bacteria, viruses and parasites. There is less evidence concerning the implication of fungal infection in carcinogenesis. The role of chronic Candida infection in the development of squamous cell carcinoma has been suspected for years. Candida sp are more prevalent in potentially malignant disorder and cancer of the oral mucosa. Other epidemiological evidence of a link between Candida infection and cancer is what is observed in patients with Autoimmune Polyendocrinopathy Candidiasis Ectodermal Dystrophy (APECED)...
February 11, 2017: Bulletin de la Société de Pathologie Exotique
https://www.readbyqxmd.com/read/28188501/effect-of-extending-the-original-eligibility-criteria-for-the-cross-neoadjuvant-chemoradiotherapy-on-toxicity-and-survival-in-esophageal-cancer
#6
E C de Heer, J B Hulshoff, D Klerk, J G M Burgerhof, D J A de Groot, J Th M Plukker, G A P Hospers
BACKGROUND: Patients with curable esophageal cancer (EC) who proceed beyond the original Chemoradiotherapy for Oesophageal Cancer Followed by Surgery Study (CROSS) eligibility criteria are also treated with neoadjuvant chemoradiotherapy (nCRT). This study assessed the effect that extending the CROSS eligibility criteria for nCRT has on treatment-related toxicity and overall survival (OS) in EC. METHODS: The study enrolled 161 patients with locally advanced EC (T1N1-3/T2-4aN0-3/M0) treated with the CROSS schedule followed by esophagectomy...
February 10, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28186102/cancer-cell-secreted-igf2-instigates-fibroblasts-and-bone-marrow-derived-vascular-progenitor-cells-to-promote-cancer-progression
#7
Wen Wen Xu, Bin Li, Xin Yuan Guan, Sookja K Chung, Yang Wang, Yim Ling Yip, Simon Y K Law, Kin Tak Chan, Nikki P Y Lee, Kwok Wah Chan, Li Yan Xu, En Min Li, Sai Wah Tsao, Qing-Yu He, Annie L M Cheung
Local interactions between cancer cells and stroma can produce systemic effects on distant organs to govern cancer progression. Here we show that IGF2 secreted by inhibitor of differentiation (Id1)-overexpressing oesophageal cancer cells instigates VEGFR1-positive bone marrow cells in the tumour macroenvironment to form pre-metastatic niches at distant sites by increasing VEGF secretion from cancer-associated fibroblasts. Cancer cells are then attracted to the metastatic site via the CXCL5/CXCR2 axis. Bone marrow cells transplanted from nude mice bearing Id1-overexpressing oesophageal tumours enhance tumour growth and metastasis in recipient mice, whereas systemic administration of VEGFR1 antibody abrogates these effects...
February 10, 2017: Nature Communications
https://www.readbyqxmd.com/read/28163000/peri-operative-chemotherapy-with-or-without-bevacizumab-in-operable-oesophagogastric-adenocarcinoma-uk-medical-research-council-st03-primary-analysis-results-of-a-multicentre-open-label-randomised-phase-2-3-trial
#8
David Cunningham, Sally P Stenning, Elizabeth C Smyth, Alicia F Okines, William H Allum, Sam Rowley, Laura Stevenson, Heike I Grabsch, Derek Alderson, Thomas Crosby, S Michael Griffin, Wasat Mansoor, Fareeda Y Coxon, Stephen J Falk, Suzanne Darby, Kate A Sumpter, Jane M Blazeby, Ruth E Langley
BACKGROUND: Peri-operative chemotherapy and surgery is a standard of care for patients with resectable oesophagogastric adenocarcinoma. Bevacizumab, a monoclonal antibody against VEGF, improves the proportion of patients responding to treatment in advanced gastric cancer. We aimed to assess the safety and efficacy of adding bevacizumab to peri-operative chemotherapy in patients with resectable gastric, oesophagogastric junction, or lower oesophageal adenocarcinoma. METHODS: In this multicentre, randomised, open-label phase 2-3 trial, we recruited patients aged 18 years and older with histologically proven, resectable oesophagogastric adenocarcinoma from 87 UK hospitals and cancer centres...
February 2, 2017: Lancet Oncology
https://www.readbyqxmd.com/read/28139076/gamma-knife-radiosurgery-for-brain-metastases-from-gastrointestinal-primary
#9
Brandi R Page, Edina C Wang, Lance White, Emory McTyre, Ann Peiffer, Angela Alistar, Frank Mu, Amritraj Loganathan, John Daniel Bourland, Adrian W Laxton, Stephen B Tatter, Michael D Chan
INTRODUCTION: In this study, we assessed clinical outcomes of patients with brain metastases from a gastrointestinal (GI) primary cancer and patterns of failure after stereotactic radiosurgery including failure within the radiosurgical volume, distant failure and leptomeningeal failure (LMF). We also assessed other factors associated with the patients' neurologic and extraneuraxial disease that may affect clinical outcomes. METHODS: We reviewed our institutional series of 62 consecutive patients with brain metastases treated with stereotactic radiosurgery, which included 17 patients with oesophageal, 44 patients with colorectal and one patient with anal canal primary...
January 31, 2017: Journal of Medical Imaging and Radiation Oncology
https://www.readbyqxmd.com/read/28139003/mortality-and-cardiovascular-diseases-risk-in-patients-with-barrett-s-oesophagus-a-population-based-nationwide-cohort-study
#10
R Erichsen, E Horvath-Puho, J L Lund, E S Dellon, N J Shaheen, L Pedersen, G D Smith, H T Sørensen
BACKGROUND: Patients with Barrett's oesophagus may be at increased risk of mortality overall, and cardiovascular disease has been suggested as the main underlying cause of death. AIM: To examine cause-specific mortality and risk of cardiovascular events among patients with Barrett's oesophagus. METHODS: Utilising existing Danish data sources (1997-2011), we identified all patients with histologically verified Barrett's oesophagus (n = 13 435) and 123 526 members of the general population matched by age, sex and individual comorbidities...
January 31, 2017: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28138154/corrigendum-mutational-signatures-in-esophageal-adenocarcinoma-define-etiologically-distinct-subgroups-with-therapeutic-relevance
#11
Maria Secrier, Xiaodun Li, Nadeera de Silva, Matthew D Eldridge, Gianmarco Contino, Jan Bornschein, Shona MacRae, Nicola Grehan, Maria O'Donovan, Ahmad Miremadi, Tsun-Po Yang, Lawrence Bower, Hamza Chettouh, Jason Crawte, Núria Galeano-Dalmau, Anna Grabowska, John Saunders, Tim Underwood, Nicola Waddell, Andrew P Barbour, Barbara Nutzinger, Achilleas Achilleos, Paul A W Edwards, Andy G Lynch, Simon Tavaré, Rebecca C Fitzgerald
No abstract text is available yet for this article.
January 31, 2017: Nature Genetics
https://www.readbyqxmd.com/read/28134566/oesophageal-cancer-staging-a-minefield-of-measurements-author-s-reply
#12
Francesco Giganti, Alessandro Ambrosi, Antonio Esposito, Alessandro Del Maschio, Francesco De Cobelli
No abstract text is available yet for this article.
January 30, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28134565/oesophageal-cancer-staging-a-minefield-of-measurements
#13
Aditya Borakati
No abstract text is available yet for this article.
January 30, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28132182/applications-of-metabolomics-in-cancer-studies
#14
Emily Grace Armitage, Michal Ciborowski
Since the start of metabolomics as a field of research, the number of studies related to cancer has grown to such an extent that cancer metabolomics now represents its own discipline. In this chapter, the applications of metabolomics in cancer studies are explored. Different approaches and analytical platforms can be employed for the analysis of samples depending on the goal of the study and the aspects of the cancer metabolome being investigated. Analyses have concerned a range of cancers including lung, colorectal, bladder, breast, gastric, oesophageal and thyroid, amongst others...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28128203/rhomboid-family-member-2-regulates-cytoskeletal-stress-associated-keratin-16
#15
Thiviyani Maruthappu, Anissa Chikh, Benjamin Fell, Paul J Delaney, Matthew A Brooke, Clemence Levet, Angela Moncada-Pazos, Akemi Ishida-Yamamoto, Diana Blaydon, Ahmad Waseem, Irene M Leigh, Matthew Freeman, David P Kelsell
Keratin 16 (K16) is a cytoskeletal scaffolding protein highly expressed at pressure-bearing sites of the mammalian footpad. It can be induced in hyperproliferative states such as wound healing, inflammation and cancer. Here we show that the inactive rhomboid protease RHBDF2 (iRHOM2) regulates thickening of the footpad epidermis through its interaction with K16. K16 expression is absent in the thinned footpads of irhom2(-/-) mice compared with irhom2(+/+)mice, due to reduced keratinocyte proliferation. Gain-of-function mutations in iRHOM2 underlie Tylosis with oesophageal cancer (TOC), characterized by palmoplantar thickening, upregulate K16 with robust downregulation of its type II keratin binding partner, K6...
January 27, 2017: Nature Communications
https://www.readbyqxmd.com/read/28120720/the-role-of-epidermal-growth-factor-receptor-in-the-management-of-gastrointestinal-carcinomas-present-status-and-future-perspectives
#16
Malik Quasir Mahmood, Shakti Dhar Shukla, Kamal Dua, Madhur D Shastri
BACKGROUND: The global burden of gastrointestinal cancers, including colorectal, stomach, and esophageal cancers is rising steadily. Several therapeutic approaches have been considered for the treatment of GI carcinomas. However, none showed to halt or cure the disease. There is a need to develop effective targeted molecular therapies; mainly to overcome the adverse effects of currently used treatment regimens, as well as, to benefit a large proportion of cancer patients who do not respond well to chemotherapeutics...
January 24, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28120520/chemoradiation-combined-with-regional-hyperthermia-for-advanced-oesophageal-cancer-a-systematic-review-and-meta-analysis
#17
REVIEW
Y Hu, Z Li, D-H Mi, N Cao, S-W Zu, Z-Z Wen, X-L Yu, Y Qu
WHAT IS KNOWN AND OBJECTIVE: Hyperthermia is an effective treatment modality that augments the anticancer effects of radiotherapy and chemotherapy. Hyperthermia-chemo-radiotherapy (HCRT) is a combination therapy that can strengthen anticancer effects through a synergistic interaction between heat, chemotherapy and radiation. Here, we carried out a systematic review and meta-analysis to evaluate the clinical efficacy and safety of chemoradiation combined with regional hyperthermia (HCRT) for oesophageal carcinoma...
January 25, 2017: Journal of Clinical Pharmacy and Therapeutics
https://www.readbyqxmd.com/read/28120338/the-effect-of-medications-which-cause-inflammation-of-the-gastro-oesophageal-tract-on-cancer-risk-a-nested-case-control-study-of-routine-scottish-data
#18
John Busby, Peter Murchie, Liam Murray, Lisa Iversen, Amanda J Lee, Andrew Spence, Margaret C Watson, Chris R Cardwell
Bisphosphonate, tetracycline and spironolactone use has been shown to increase gastro-oesophageal inflammation, an accepted risk factor for cancer. However, evidence on the effect of these medications on gastro-oesophageal cancer risk are mixed or missing entirely. Therefore, we conducted a nested case-control study using the Primary Care Clinical Information Unit Research (PCCIUR) database from Scotland. Cases with oesophageal or gastric cancer between 1999 and 2011 were matched to up to five controls based on age, gender, year of diagnosis and general practice...
January 24, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28117415/genetics-oesophageal-cancer-not-all-alike
#19
Diana Romero
No abstract text is available yet for this article.
January 24, 2017: Nature Reviews. Clinical Oncology
https://www.readbyqxmd.com/read/28105699/neat1-a-novel-cancer-related-long-non-coding-rna
#20
REVIEW
Xin Yu, Zheng Li, Heyi Zheng, Matthew T V Chan, William Ka Kei Wu
Aberrant overexpression of the long non-coding RNA NEAT1 (nuclear paraspeckle assembly transcript 1) has been documented in different types of solid tumours, such as lung cancer, oesophageal cancer, colorectal cancer and hepatocellular carcinoma, in which its high levels are associated with poor prognosis. In contrast, NEAT1 is downregulated in acute promyelocytic leukaemia where it promotes leucocyte differentiation. In this review, we provide an overview of current evidence concerning the oncogenic role and potential clinical utilities of NEAT1...
January 19, 2017: Cell Proliferation
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