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https://www.readbyqxmd.com/read/29034252/age-and-outcome-in-gastrointestinal-cancers-a-population-based-evaluation-of-oesophageal-gastric-and-colorectal-cancer
#1
Anne Schlesinger-Raab, Jens Werner, Helmut Friess, Dieter Hölzel, Jutta Engel
BACKGROUND: With demographic changes and partial representativeness of randomized studies the question arises which results are achieved in the treatment of the elderly. The objective was to analyse population-based data on gastrointestinal cancers in terms of age. METHODS: Analyses included data of the Munich Cancer Registry, i.e. 4,014, 10,127 and 42,809 invasive oesophageal, gastric and colorectal cancer patients, respectively, which were diagnosed between 1998 and 2014...
August 2017: Visceral Medicine
https://www.readbyqxmd.com/read/29029833/interim-18-f-fdg-pet-ct-during-chemo-radiotherapy-in-the-management-of-oesophageal-cancer-patients-a-systematic-review
#2
REVIEW
Marta Cremonesi, Cristina Garibaldi, Robert Timmerman, Mahila Ferrari, Sara Ronchi, Chiara Maria Grana, Laura Travaini, Laura Gilardi, Anna Starzyńska, Delia Ciardo, Roberto Orecchia, Barbara Alicja Jereczek-Fossa, Maria Cristina Leonardi
Oesophageal cancer is an aggressive disease. The possibility to early stratify patients as responsive and non-responsive with a non-invasive method is extremely appealing. The uptake of Fluorodeoxyglucose ((18)F-FDG) in tumours, provided by positron emission tomography (PET) images, has been proved to be useful to assess the initial staging of the disease, recurrence, and response to chemotherapy and chemo-radiotherapy (CRT). In the last years, efforts have been focused on the possibility to use ad interim (18)F-FDG-PET/CT (PETint) to evaluate response during radiation therapy...
October 10, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29029002/infrared-intraoperative-fluorescence-imaging-using-indocyanine-green-in-thoracic-surgery
#3
Olugbenga T Okusanya, Nicholas R Hess, James D Luketich, Inderpal S Sarkaria
Thoracic surgery faces many unique challenges that require innovative solutions. The increase in utilization of minimally invasive practices, poor overall cancer survival and significant morbidity of key operations remain key obstacles to overcome. Intraoperative fluorescence imaging is a process by which fluorescent dyes and imaging systems are used as adjuncts for surgeons in the operating room. Other surgical subspecialists have shown that intraoperative fluorescence imaging can be applied as a practical adjunct to their practices...
September 27, 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/29027485/concentration-dependent-effect-of-fumonisin-b1-on-apoptosis-in-oesophageal-cancer-cells
#4
R B Khan, A Phulukdaree, A A Chuturgoon
The geographical distribution of oesophageal cancer is linked to the exposure of fumonisin B1 (FB1), a mycotoxin produced by fungi that contaminates staple food worldwide. Non-genotoxic carcinogens like FB1 disturb homeostasis through increased cell proliferation or suppression of apoptosis. This study investigated the involvement of FB1 (0-20 μM) in spindle-shaped N-cadherin (+) CD45 (-) osteoblastic (SNO) cell death. Cell viability and death were assessed using the MTS and Annexin V-Fluos assays, respectively...
January 1, 2017: Human & Experimental Toxicology
https://www.readbyqxmd.com/read/29027279/long-non-coding-rna-pvt1-emerging-biomarker-in-digestive-system-cancer
#5
REVIEW
Dan-Dan Zhou, Xiu-Fen Liu, Cheng-Wei Lu, Om Prakash Pant, Xiao-Dong Liu
The digestive system cancers are leading cause of cancer-related death worldwide, and have high risks of morbidity and mortality. More and more long non-coding RNAs (lncRNAs) have been studied to be abnormally expressed in cancers and play a key role in the process of digestive system tumour progression. Plasmacytoma variant translocation 1 (PVT1) seems fairly novel. Since 1984, PVT1 was identified to be an activator of MYC in mice. Its role in human tumour initiation and progression has long been a subject of interest...
October 12, 2017: Cell Proliferation
https://www.readbyqxmd.com/read/29024949/nutritional-optimization-during-neoadjuvant-therapy-prior-to-surgical-resection-of-esophageal-cancer-a-narrative-review
#6
Jeremy R Huddy, Fiona M S Huddy, Sheraz R Markar, Olga Tucker
This narrative review aims to evaluate the evidence for the different nutritional approaches employed during neoadjuvant therapy in patients with loco-regional esophageal cancer. Patients with esophageal cancer are often malnourished and difficult to optimise nutritionally. Whilst evidence suggests neoadjuvant therapy can offer a survival advantage, associated toxicity can exacerbate poor nutritional status. There is currently no accepted standard of care regarding optimal nutritional approach.A systematic literature search was undertaken...
August 30, 2017: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://www.readbyqxmd.com/read/28993052/nivolumab-in-patients-with-advanced-gastric-or-gastro-oesophageal-junction-cancer-refractory-to-or-intolerant-of-at-least-two-previous-chemotherapy-regimens-ono-4538-12-attraction-2-a-randomised-double-blind-placebo-controlled-phase-3-trial
#7
Yoon-Koo Kang, Narikazu Boku, Taroh Satoh, Min-Hee Ryu, Yee Chao, Ken Kato, Hyun Cheol Chung, Jen-Shi Chen, Kei Muro, Won Ki Kang, Kun-Huei Yeh, Takaki Yoshikawa, Sang Cheul Oh, Li-Yuan Bai, Takao Tamura, Keun-Wook Lee, Yasuo Hamamoto, Jong Gwang Kim, Keisho Chin, Do-Youn Oh, Keiko Minashi, Jae Yong Cho, Masahiro Tsuda, Li-Tzong Chen
BACKGROUND: Patients with advanced gastric or gastro-oesophageal junction cancer refractory to, or intolerant of, two or more previous regimens of chemotherapy have a poor prognosis, and current guidelines do not recommend any specific treatments for these patients. We assessed the efficacy and safety of nivolumab, a fully human IgG4 monoclonal antibody inhibitor of programmed death-1 (PD-1), in patients with advanced gastric or gastro-oesophageal junction cancer who had been previously been treated with two or more chemotherapy regimens...
October 5, 2017: Lancet
https://www.readbyqxmd.com/read/28983402/regulatory-t-cell-heterogeneity-and-the-cancer-immune-response
#8
REVIEW
Kirsten A Ward-Hartstonge, Roslyn A Kemp
The frequency of circulating or tumour-infiltrating regulatory T cells (Tregs) has been associated with poor patient survival in many cancers including breast, melanoma and lung. It has been hypothesised that Tregs impact the anti-tumour function of effector T cells, resulting in worse outcomes for patients. However, high infiltrates of Tregs have been associated with a positive outcome of patients in a minority of cancers including colorectal, bladder and oesophageal. In addition, many studies have shown no impact of Tregs in patient outcome...
September 2017: Clinical & Translational Immunology
https://www.readbyqxmd.com/read/28982887/chemoradiotherapy-for-solitary-skeletal-muscle-metastasis-from-oesophageal-cancer-case-report-and-brief-literature-review
#9
REVIEW
Yoshiaki Fujimoto, Yuichiro Nakashima, Shun Sasaki, Tomoko Jogo, Kosuke Hirose, Keitaro Edahiro, Shotaro Korehisa, Daisuke Taniguchi, Kensuke Kudou, Y U Nakaji, Ryota Nakanishi, Koji Ando, Hiroshi Saeki, Eiji Oki, Minako Fujiwara, Yoshinao Oda, Yoshihiko Maehara
BACKGROUND: The incidence of skeletal muscle metastasis from oesophageal cancer is very low, and the treatment strategy has not been established. CASE REPORT: A 77-year-old man underwent oesophagectomy following neoadjuvant chemotherapy for oesophageal squamous cell carcinoma (CT-pT3 N0 M0, CT-pStage II). Fourteen months after surgery, he became aware of a subcutaneous tumour in his left forearm. Computed tomography and fluorodeoxyglucose positron-emission tomography revealed a 65×75 mm intramuscular nodular lesion with a standardized uptake value of 8...
October 2017: Anticancer Research
https://www.readbyqxmd.com/read/28979718/characterisation-and-risk-assessment-of-venous-thromboembolism-in-gastrointestinal-cancers
#10
Robert L Metcalf, Eamon Al-Hadithi, Nicholas Hopley, Thomas Henry, Clare Hodgson, Antony McGurk, Wasat Mansoor, Jurjees Hasan
AIM: To characterise venous thromboembolism (VTE) in gastrointestinal cancer and assess the clinical utility of risk stratification scoring. METHODS: We performed a retrospective analysis using electronic patient records of 910 gastro-oesophageal (GO) cancer and 1299 colorectal cancer (CRC) patients referred to a tertiary cancer centre to identify the incidence of VTE, its relationship to chemotherapy and impact on survival. VTE risk scores were calculated using the Khorana index...
September 15, 2017: World Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/28978306/respiratory-gated-4d-contrast-enhanced-fdg-pet-ct-for-radiotherapy-planning-of-lower-oesophageal-carcinoma-feasibility-and-impact-on-planning-target-volume
#11
Andrew Scarsbrook, Gillian Ward, Patrick Murray, Rebecca Goody, Karen Marshall, Garry McDermott, Robin Prestwich, Ganesh Radhakrishna
BACKGROUND: To assess the feasibility and potential impact on target delineation of respiratory-gated (4D) contrast-enhanced (18)Fluorine fluorodeoxyglucose (FDG) positron emission tomography - computed tomography (PET-CT), in the treatment planning position, for a prospective cohort of patients with lower third oesophageal cancer. METHODS: Fifteen patients were recruited into the study. Imaging included 4D PET-CT, 3D PET-CT, endoscopic ultrasound and planning 4D CT...
October 4, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28977486/anatomical-distribution-of-residual-cancer-in-patients-with-oesophageal-squamous-cell-carcinoma-who-achieved-clinically-complete-response-after-neoadjuvant-chemoradiotherapy
#12
Yin-Kai Chao, Wen-Yu Chuang, Chi-Ju Yeh, Hsien-Kun Chang, Chen-Kan Tseng
OBJECTIVES: Recent advances in neoadjuvant chemoradiotherapy (nCRT) have significantly increased the rates of pathological complete response achieved by patients with oesophageal cancer. Consequently, a watchful waiting strategy based on 'active endoscopic surveillance and surgery as needed' has been proposed for cases without clinical evidence of disease after neoadjuvant chemoradiotherapy. Here, we investigated whether endoscopic surveillance is a reliable tool for the detection of the initially unidentified residual cancer in this patient group...
July 20, 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/28977436/the-role-of-individualized-treatment-in-patients-with-oesophageal-cancer-mind-the-patient-and-not-only-the-disease
#13
Demetrios Moris, Dimitrios Schizas, Eleftherios Spartalis, Antonios Athanasiou
No abstract text is available yet for this article.
July 20, 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/28974564/corrigendum-a-comparative-analysis-of-whole-genome-sequencing-of-esophageal-adenocarcinoma-pre-and-post-chemotherapy
#14
Ayesha Noorani, Jan Bornschein, Andy G Lynch, Maria Secrier, Achilleas Achilleos, Matthew Eldridge, Lawrence Bower, Jamie M J Weaver, Jason Crawte, Chin-Ann Ong, Nicholas Shannon, Shona MacRae, Nicola Grehan, Barbara Nutzinger, Maria O'Donovan, Richard Hardwick, Simon Tavaré, Rebecca C Fitzgerald
No abstract text is available yet for this article.
October 2017: Genome Research
https://www.readbyqxmd.com/read/28970029/effect-of-diagnosis-surveillance-and-treatment-of-barrett-s-oesophagus-on-health-related-quality-of-life
#15
REVIEW
James Britton, Richard Keld, Neeraj Prasad, Shaheen Hamdy, John McLaughlin, Yeng Ang
Barrett's oesophagus is a chronic precancerous condition that predisposes patients to the development of oesophageal adenocarcinoma, which, once invasive, carries a poor prognosis. This likelihood of a negative outcome has led to the development of robust surveillance and treatment pathways. The true effect of Barrett's oesophagus on life expectancy and the efficacy of long-term surveillance remains under debate. With these uncertainties and no reliable methods of individual risk stratification, patients must be continually monitored and thus carry the burden of this chronic disease...
September 29, 2017: Lancet. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28969123/prevalence-of-specific-helicobacter-pyloricaga-vaca-icea-urec-genotypes-and-its-clinical-relevance-in-the-patients-with-acid-peptic-diseases
#16
Himani Bhardwaj Pandya, Harihar Hardas Agravat, Jagdish Shantilal Patel
INTRODUCTION: Virulent markers of H. pylori, the vacuolating cytotoxin (vacA), cytotoxin-associated gene A (cagA), induced by contact with epithelium factor antigen (iceA gene) and the urease C gene (ureC) may plays a major role in determining the clinical outcome of Helicobacter infections. AIM: To detect the prevalence of the cagA, vacA, ureC and iceA genotypes of H. pylori from antral biopsy specimens of patients and to associate its role in specific disease...
August 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28958504/rilotumumab-plus-epirubicin-cisplatin-and-capecitabine-as-first-line-therapy-in-advanced-met-positive-gastric-or-gastro-oesophageal-junction-cancer-rilomet-1-a-randomised-double-blind-placebo-controlled-phase-3-trial
#17
Daniel V T Catenacci, Niall C Tebbutt, Irina Davidenko, André M Murad, Salah-Eddin Al-Batran, David H Ilson, Sergei Tjulandin, Evengy Gotovkin, Boguslawa Karaszewska, Igor Bondarenko, Mohamedtaki A Tejani, Anghel A Udrea, Mustapha Tehfe, Ferdinando De Vita, Cheryl Turkington, Rui Tang, Agnes Ang, Yilong Zhang, Tien Hoang, Roger Sidhu, David Cunningham
BACKGROUND: Rilotumumab is a fully human monoclonal antibody that selectively targets the ligand of the MET receptor, hepatocyte growth factor (HGF). We aimed to assess the efficacy, safety, and pharmacokinetics of rilotumumab combined with epirubicin, cisplatin, and capecitabine, and to assess potential biomarkers, in patients with advanced MET-positive gastric or gastro-oesophageal junction adenocarcinoma. METHODS: This multicentre, randomised, double-blind, placebo-controlled, phase 3 study was done at 152 centres in 27 countries...
September 25, 2017: Lancet Oncology
https://www.readbyqxmd.com/read/28955435/exposure-to-biomass-smoke-as-a-risk-factor-for-oesophageal-and-gastric-cancer-in-low-income-populations-a-systematic-review
#18
REVIEW
Violet Kayamba, Douglas C Heimburger, Douglas R Morgan, Masharip Atadzhanov, Paul Kelly
BACKGROUND: Upper gastrointestinal cancers contribute significantly to cancer-related morbidity and mortality in sub-Saharan Africa, but they continue to receive limited attention. The high incidence in young adults remains unexplained, and the risk factors have not been fully described. METHODS: A literature search was conducted using the electronic database PubMed. Beginning from January 1980 to February 2016, all articles evaluating biomass smoke exposure with oesophageal and gastric cancer were reviewed...
June 2017: Malawi Medical Journal: the Journal of Medical Association of Malawi
https://www.readbyqxmd.com/read/28955421/risk-factors-for-common-cancers-among-patients-at-kamuzu-central-hospital-in-lilongwe-malawi-a-retrospective-cohort-study
#19
Agnes Moses, Albert Mwafongo, Maria Chikasema, Laureen Kafantenganji, Christopher Stanely, Emma Chimzukira, Coxcilly Kampani, Robert Krysiak, Satish Gopal, Nora E Rosenberg, Carol G Shores, Mina C Hosseinipour
BACKGROUND: Little is known about risk factors for different cancers in Malawi. This study aimed to assess risk factors for and epidemiologic patterns of common cancers among patients treated at Kamuzu Central Hospital (KCH) in Lilongwe, and to determine the prevalence of Human Immunodeficiency Virus (HIV) infection in the same population. METHODS: We analysed data from the hospital-based KCH cancer registry, from June 2009 to September 2012, including data from a nested substudy on coinfections among cancer patients...
June 2017: Malawi Medical Journal: the Journal of Medical Association of Malawi
https://www.readbyqxmd.com/read/28955420/characterising-cancer-burden-and-quality-of-care-at-two-palliative-care-clinics-in-malawi
#20
Victoria Mukhula, Daisy Sibale, Lubna Tarmahomed, Charles Dzamalala, Kelias Msyamboza, Steady Chasimpha
BACKGROUND: This paper describes cancer burden and compares characteristics of cancer patients enrolled at 2 palliative care facilities of contrasting resources and geographical locations in Malawi. It also assesses the extent of differences in service delivery and the impact these might have on outcomes. METHODS: Data on all cancer patients registered between October 2010 and October 2015 at Tiyanjane Clinic (at Queen Elizabeth Central Hospital, Blantyre) and Mzuzu Central Hospital (MCH) palliative care clinics were extracted and analysed...
June 2017: Malawi Medical Journal: the Journal of Medical Association of Malawi
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