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https://www.readbyqxmd.com/read/29465751/prognostic-value-of-pathological-lymph-node-status-and-primary-tumour-regression-grading-following-neoadjuvant-chemotherapy-results-from-the-mrc-oe02-oesophageal-cancer-trial
#1
Nasser Davarzani, Gordon G A Hutchins, Nicholas P West, Lindsay C Hewitt, Mathew Nankivell, David Cunningham, William H Allum, Elizabeth Smyth, Nicola Valeri, Ruth E Langley, Heike I Grabsch
AIMS: Neoadjuvant chemotherapy (NAC) remains an important therapeutic option for advanced oesophageal cancer (OC). Pathological tumour regression grade (TRG) may offer additional information by directing adjuvant treatment and/or follow-up but clinical value remains unclear. We analysed the prognostic value of TRG and associated pathological factors in OC patients enrolled in the Medical Research Council OE02 trial. METHODS: Histopathology was reviewed in 497 resections from OE02 trial participants randomised to surgery (S-group;n=244) or NAC followed by surgery (CS-group;n=253)...
February 21, 2018: Histopathology
https://www.readbyqxmd.com/read/29465746/using-textbook-outcome-as-a-measure-of-quality-of-care-in-oesophagogastric-cancer-surgery
#2
R T van der Kaaij, M V de Rooij, F van Coevorden, F E M Voncken, P Snaebjornsson, H Boot, J W van Sandick
BACKGROUND: Textbook outcome is a multidimensional measure representing an ideal course after oesophagogastric cancer surgery. It comprises ten perioperative quality-of-care parameters and has been developed recently using population-based data. Its association with long-term outcome is unknown. The objectives of this study were to validate the clinical relevance of textbook outcome at a hospital level, and to assess its relation with long-term survival after treatment for oesophagogastric cancer...
February 21, 2018: British Journal of Surgery
https://www.readbyqxmd.com/read/29460796/effects-of-goal-directed-fluid-therapy-on-enhanced-postoperative-recovery-an-interventional-comparative-observational-study-with-a-historical-control-group-on-oesophagectomy-combined-with-eras-program
#3
Hideki Taniguchi, Toshio Sasaki, Hisae Fujita, Hiroko Kobayashi, Rieko Kawasaki, Takashi Ogata, Haruhiko Cho, Takaki Yoshikawa, Keiko Ushigome, Akemi Tanaka, Osami Takano
BACKGROUND AND AIMS: The Enhanced Recovery after Surgery (ERAS) program has been proposed as a postoperative recovery-enhancing strategy. We frequently apply the Modified-ERAS program following oesophagectomy. This study aims to elucidate the impact of goal-directed fluid therapy (GDT) for the perioperative management of oesophageal cancer on the postoperative recovery of patients undergoing oesophagectomy. METHODS: This is an interventional before-after comparative observational study conducted at Kanagawa Cancer Centre, Japan...
February 2018: Clinical Nutrition ESPEN
https://www.readbyqxmd.com/read/29458786/ecco-essential-requirements-for-quality-cancer-care-oesophageal-and-gastric-cancer
#4
REVIEW
William Allum, Florian Lordick, Maria Alsina, Elisabeth Andritsch, Ahmed Ba-Ssalamah, Marc Beishon, Marco Braga, Carmela Caballero, Fatima Carneiro, Fernando Cassinello, Jan Willem Dekker, Roberto Delgado-Bolton, Karin Haustermans, Geoffrey Henning, Bettina Hutter, József Lövey, Irena Štenglová Netíková, Radka Obermannová, Simon Oberst, Siri Rostoft, Tiina Saarto, Thomas Seufferlein, Sapna Sheth, Venetia Wynter-Blyth, Alberto Costa, Peter Naredi
BACKGROUND: ECCO essential requirements for quality cancer care (ERQCC) are checklists and explanations of organisation and actions that are necessary to give high-quality care to patients who have a specific type of cancer. They are written by European experts representing all disciplines involved in cancer care. ERQCC papers give oncology teams, patients, policymakers and managers an overview of the elements needed in any healthcare system to provide high quality of care throughout the patient journey...
February 2018: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/29455047/prospective-cohort-study-of-neoadjuvant-therapy-toxicity-in-the-treatment-of-oesophageal-adenocarcinoma
#5
David Bunting, Richard Berrisford, Tim Wheatley, Lee Humphreys, Arun Ariyarathenam, Grant Sanders
BACKGROUND: Early studies investigating the benefits of neoadjuvant therapy in oesophageal cancer showed conflicting results, taking many years before a survival advantage was demonstrated in randomised trials. Gains are modest, limited by progressive disease and toxicity. This study aimed to investigate the relationship between neoadjuvant therapy-associated toxicity and clinical outcomes including survival in patients with potentially curable oesophageal adenocarcinoma. MATERIALS AND METHODS: A cohort of 286 patients undergoing neoadjuvant therapy followed by surgical resection at a single institution was identified from a prospective database...
February 15, 2018: International Journal of Surgery
https://www.readbyqxmd.com/read/29454737/adjuvant-radiotherapy-for-positive-lymph-nodes-of-oesophageal-squamous-cell-carcinoma-can-it-earn-promising-benefits-at-long-term-follow-up
#6
Y Ren, J Ye, W Xiong, J Zuo, Y He, M Tan, Y Yuan
PURPOSE: The value of adjuvant radiotherapy for patients with positive lymph nodes after curative resection of oesophageal squamous cell carcinoma is controversial. This study aims to investigate its long-term benefits in a specific cohort. PATIENTS AND METHODS: The charts between 1990 and 2003 from patients with positive lymph nodes were retrospectively reviewed. Those subjects were divided into adjuvant radiotherapy and surgery alone groups, with two subgroups defined by radiation dose (cutoff value: 50Gy)...
February 14, 2018: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
https://www.readbyqxmd.com/read/29437560/drinking-very-hot-tea-linked-to-oesophageal-cancer
#7
Jacqui Wise
No abstract text is available yet for this article.
February 5, 2018: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/29437041/preoperative-exercise-halves-the-postoperative-complication-rate-in-patients-with-lung-cancer-a-systematic-review-of-the-effect-of-exercise-on-complications-length-of-stay-and-quality-of-life-in-patients-with-cancer
#8
REVIEW
Daniel Steffens, Paula R Beckenkamp, Mark Hancock, Michael Solomon, Jane Young
OBJECTIVE: To investigate the effectiveness of preoperative exercises interventions in patients undergoing oncological surgery, on postoperative complications, length of hospital stay and quality of life. DESIGN: Intervention systematic review with meta-analysis. DATA SOURCES: MEDLINE, Embase and PEDro. ELIGIBILITY CRITERIA FOR SELECTING STUDIES: Trials investigating the effectiveness of preoperative exercise for any oncological patient undergoing surgery were included...
February 1, 2018: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/29435872/a-phase-ii-trial-of-concurrent-chemoradiotherapy-with-weekly-paclitaxel-and-carboplatin-in-advanced-oesophageal-carcinoma
#9
Kuai-Le Zhao, Yi Xia, Yun-Hai Li, Yun Chen, Qi Liu, Jun-Hua Zhang, Jia-Ying Deng, Ta-Shan Ai, Han-Ting Zhu, Harun Badakhshi
BACKGROUND: This study was performed to assess the efficacy and feasibility of definitive chemoradiotherapy consisting of weekly doses of combined paclitaxel and carboplatin concurrent with radiation therapy, followed by 2 cycles of consolidation chemotherapy for advanced esophageal carcinoma. METHODS: Eligibility criteria included local, advanced, newly diagnosed and postoperative local regional lymph node metastasis; Eastern Cooperative Oncology Group (ECOG) score ≤ 2; and adequate organ function...
February 12, 2018: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29433991/changes-in-volume-clinical-practice-and-outcome-after-reorganisation-of-oesophago-gastric-cancer-care-in-england-a-longitudinal-observational-study
#10
M Varagunam, R Hardwick, S Riley, G Chadwick, D A Cromwell, O Groene
AIM: The centralisation of oesophago-gastric (O-G) cancer services in England was recommended in 2001, partly because of evidence for a volume-outcome effect for patients having surgery. This study investigated the changes in surgical services for O-G cancer and postoperative mortality since centralisation. METHODS: Patients with O-G cancer who had an oesophageal or gastric resection between April 2003 and March 2014 were identified in the national Hospital Episodes Statistics database...
January 11, 2018: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29431541/an-update-on-the-use-of-raman-spectroscopy-in-molecular-cancer-diagnostics-current-challenges-and-further-prospects
#11
E Upchurch, M Isabelle, Gavin Rhys Lloyd, C Kendall, H Barr
Introduction Cancer is responsible for an extraordinary burden of disease, affecting 90.5 million people worldwide in 2015. Outcomes for these patients are improved when the disease is diagnosed at an early, or even precancerous, stage. Raman spectroscopy is demonstrating results that show its ability to detect the molecular changes that are diagnostic of precancerous and cancerous tissue. This review highlights the new advances occurring in this domain. Areas Covered PubMed searches were undertaken to identify new research in the utilisation of Raman spectroscopy in cancer diagnostics...
February 12, 2018: Expert Review of Molecular Diagnostics
https://www.readbyqxmd.com/read/29412450/intrathoracic-versus-cervical-anastomosis-and-predictors-of%C3%A2-anastomotic-leakage-after-oesophagectomy-for-cancer
#12
J A H Gooszen, L Goense, S S Gisbertz, J P Ruurda, R van Hillegersberg, M I van Berge Henegouwen
BACKGROUND: Studies comparing the anastomotic leak rate in patients with an intrathoracic versus a cervical anastomosis after oesophagectomy are equivocal. The aim of this study was to compare clinical outcome after oesophagectomy in patients with an intrathoracic or cervical anastomosis, and to identify predictors of anastomotic leakage in a nationwide audit. METHODS: Between January 2011 and December 2015, all consecutive patients who underwent oesophagectomy for cancer were identified from the Dutch Upper Gastrointestinal Cancer Audit...
February 7, 2018: British Journal of Surgery
https://www.readbyqxmd.com/read/29409469/neoadjuvant-chemoradiotherapy-plus-surgery-versus-active-surveillance-for-oesophageal-cancer-a-stepped-wedge-cluster-randomised-trial
#13
Bo Jan Noordman, Bas P L Wijnhoven, Sjoerd M Lagarde, Jurjen J Boonstra, Peter Paul L O Coene, Jan Willem T Dekker, Michael Doukas, Ate van der Gaast, Joos Heisterkamp, Ewout A Kouwenhoven, Grard A P Nieuwenhuijzen, Jean-Pierre E N Pierie, Camiel Rosman, Johanna W van Sandick, Maurice J C van der Sangen, Meindert N Sosef, Manon C W Spaander, Roelf Valkema, Edwin S van der Zaag, Ewout W Steyerberg, J Jan B van Lanschot
BACKGROUND: Neoadjuvant chemoradiotherapy (nCRT) plus surgery is a standard treatment for locally advanced oesophageal cancer. With this treatment, 29% of patients have a pathologically complete response in the resection specimen. This provides the rationale for investigating an active surveillance approach. The aim of this study is to assess the (cost-)effectiveness of active surveillance vs. standard oesophagectomy after nCRT for oesophageal cancer. METHODS: This is a phase-III multi-centre, stepped-wedge cluster randomised controlled trial...
February 6, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29405281/health-related-quality-of-life-after-open-transhiatal-and-transthoracic-oesophagectomy-for-cancer
#14
J H Kauppila, A Johar, J A Gossage, A R Davies, J Zylstra, J Lagergren, P Lagergren
BACKGROUND: Transhiatal and transthoracic oesophagectomy in patients with oesophageal cancer have similar survival rates. Whether these approaches differ in health-related quality of life (HRQoL) is uncertain and was examined in this study. METHODS: Patients undergoing transhiatal or transthoracic surgery for lower-third oesophageal or gastro-oesophageal junctional cancer between 2011 and 2015 were selected from an institutional database. HRQoL outcomes were measured at 6 and 12 months after surgery using validated written questionnaires (European Organisation for Research and Treatment of Cancer QLQ-C30 and QLQ-OG25)...
February 2018: British Journal of Surgery
https://www.readbyqxmd.com/read/29396851/medications-that-relax-the-lower-oesophageal-sphincter-and-risk-of-oesophageal-cancer-an-analysis-of-two-independent-population-based-databases
#15
Andrew D Spence, John Busby, Peter Murchie, Andrew T Kunzmann, Úna C McMenamin, Helen G Coleman, Brian T Johnston, Michael A O'Rorke, Liam J Murray, Lisa Iversen, Amanda J Lee, Chris R Cardwell
Excessive lower oesophageal sphincter relaxation increases gastro-oesophageal acid reflux, an oesophageal adenocarcinoma risk factor. Medications that relax this sphincter (benzodiazepines, calcium channel blockers, nitrates, β2 agonists and xanthines) could promote cancer. These medications were investigated in two independent datasets. In the Scottish Primary Care Clinical Informatics Unit (PCCIU) database, a nested case-control study of oesophageal cancer was performed using GP prescription records. Conditional logistic regression was used to calculate odds ratios (OR) and 95% confidence intervals (CIs) for medication use and oesophageal cancer...
February 3, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29395269/global-surveillance-of-trends-in-cancer-survival-2000-14-concord-3-analysis-of-individual-records-for-37%C3%A2-513%C3%A2-025-patients-diagnosed-with-one-of-18-cancers-from-322-population-based-registries-in-71-countries
#16
Claudia Allemani, Tomohiro Matsuda, Veronica Di Carlo, Rhea Harewood, Melissa Matz, Maja Nikšić, Audrey Bonaventure, Mikhail Valkov, Christopher J Johnson, Jacques Estève, Olufemi J Ogunbiyi, Gulnar Azevedo E Silva, Wan-Qing Chen, Sultan Eser, Gerda Engholm, Charles A Stiller, Alain Monnereau, Ryan R Woods, Otto Visser, Gek Hsiang Lim, Joanne Aitken, Hannah K Weir, Michel P Coleman
BACKGROUND: In 2015, the second cycle of the CONCORD programme established global surveillance of cancer survival as a metric of the effectiveness of health systems and to inform global policy on cancer control. CONCORD-3 updates the worldwide surveillance of cancer survival to 2014. METHODS: CONCORD-3 includes individual records for 37·5 million patients diagnosed with cancer during the 15-year period 2000-14. Data were provided by 322 population-based cancer registries in 71 countries and territories, 47 of which provided data with 100% population coverage...
January 30, 2018: Lancet
https://www.readbyqxmd.com/read/29390981/selective-oestrogen-receptor-antagonists-inhibit-oesophageal-cancer-cell-proliferation-in-vitro
#17
Waleed Al-Khyatt, Cristina Tufarelli, Raheela Khan, Syed Yousef Iftikhar
BACKGROUND: Oestrogen receptors (ER) have a well-established role to the initiation, progression and regulation of responses to treatment of breast, prostate, and lung cancers. Previous data indicates altered ER expression in oesophageal cancers (OC). However the role of ER subtypes and ER specific inhibitors in the regulation of OC progression remains unclear. This study sought to assess levels of ERα and ERβ in OC. The effects of highly selective ER antagonists on cell proliferation and apoptosis in two OC adenocarcinoma cell lines was also studied...
February 1, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29378575/effects-of-omegaven%C3%A2-epa-dha-and-oxaliplatin-on-oesophageal-adenocarcinoma-cell-lines-growth-cytokine-and-cell-signal-biomarkers-expression
#18
Amar M Eltweri, Lynne M Howells, Anne L Thomas, Ashley R Dennison, David J Bowrey
BACKGROUND: There is limited evidence assessing the effects of omega-3 polyunsaturated fatty acids (PUFAs) on oesophageal adenocarcinoma, both in vitro and in vivo. We evaluated the effects of the omega-3 PUFA and oxaliplatin on OE33 and OE19 cells. METHOD: The two oesophageal cells were treated with Omegaven® (fish oil emulsion), EPA, DHA and oxaliplatin and incubated for up to 144 h. RESULTS: The following inhibitory effects were observed on OE33 cells: EPA reduced cell growth by 39% (p = 0...
January 30, 2018: Lipids in Health and Disease
https://www.readbyqxmd.com/read/29376555/reply-to-technical-comment-on-g%C3%A3-ller-et-al-lower-hospital-volume-is-associated-with-higher-mortality-after-oesophageal-gastric-pancreatic-and-rectal-cancer-resection
#19
Ulrich Güller, Rene Warschkow, Christoph Jakob Ackermann, Bruno M Schmied, Thomas Cerny, Silvia Ess
No abstract text is available yet for this article.
January 29, 2018: Swiss Medical Weekly
https://www.readbyqxmd.com/read/29376549/technical-comment-on-g%C3%A3-ller-et-al-lower-hospital-volume-is-associated-with-higher-mortality-after-oesophageal-gastric-pancreatic-and-rectal-cancer-resection
#20
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