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https://www.readbyqxmd.com/read/27918562/resting-state-connectivity-biomarkers-define-neurophysiological-subtypes-of-depression
#1
Andrew T Drysdale, Logan Grosenick, Jonathan Downar, Katharine Dunlop, Farrokh Mansouri, Yue Meng, Robert N Fetcho, Benjamin Zebley, Desmond J Oathes, Amit Etkin, Alan F Schatzberg, Keith Sudheimer, Jennifer Keller, Helen S Mayberg, Faith M Gunning, George S Alexopoulos, Michael D Fox, Alvaro Pascual-Leone, Henning U Voss, B J Casey, Marc J Dubin, Conor Liston
Biomarkers have transformed modern medicine but remain largely elusive in psychiatry, partly because there is a weak correspondence between diagnostic labels and their neurobiological substrates. Like to other neuropsychiatric disorders, depression is not a unitary disease, but rather a heterogeneous syndrome that encompasses varied, co-occurring symptoms and divergent responses to treatment. By using functional magnetic resonance imaging (fMRI) in a large multisite sample (n = 1,188), we show here that patients with depression can be subdivided into four neurophysiological subtypes ('biotypes') defined by distinct patterns of dysfunctional connectivity in limbic and frontostriatal networks...
December 5, 2016: Nature Medicine
https://www.readbyqxmd.com/read/27915376/eco-friendly-approach-for-nanoparticles-synthesis-and-mechanism-behind-antibacterial-activity-of-silver-and-anticancer-activity-of-gold-nanoparticles
#2
REVIEW
Maheshkumar Prakash Patil, Gun-Do Kim
This review covers general information about the eco-friendly process for the synthesis of silver nanoparticles (AgNP) and gold nanoparticles (AuNP) and focuses on mechanism of the antibacterial activity of AgNPs and the anticancer activity of AuNPs. Biomolecules in the plant extract are involved in reduction of metal ions to nanoparticle in a one-step and eco-friendly synthesis process. Natural plant extracts contain wide range of metabolites including carbohydrates, alkaloids, terpenoids, phenolic compounds, and enzymes...
December 3, 2016: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/27913401/the-barrel-of-the-smoking-gun-finding-diastolic-pathways-during-sinus-rhythm
#3
EDITORIAL
Nicholas S Peters, Edward J Ciaccio
No abstract text is available yet for this article.
December 2016: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/27913219/tbx2-regulates-anterior-neural-specification-by-repressing-fgf-signaling-pathway
#4
Gun-Sik Cho, Dong-Seok Park, Sun-Cheol Choi, Jin-Kwan Han
During early embryogenesis, FGF signals regulate the antero-posterior (AP) patterning of the neural plate by promoting posterior cell fates. In particular, BMP signal-mediated attenuation of FGF pathway plays a critical role in the determination of the anterior neural region. Here we show that Tbx2, a T-box transcriptional repressor regulates anterior neural specification by suppressing FGF8 signaling pathway in Xenopus embryo. Tbx2 is expressed in the anterior edge of the neural plate in early neurulae. Overexpression and knockdown of Tbx2 induce expansion and reduction in the expression of anterior neural markers, respectively...
November 30, 2016: Developmental Biology
https://www.readbyqxmd.com/read/27911389/testing-of-nanoparticle-release-from-a-composite-containing-nanomaterial-using-a-chamber-system
#5
Gun Ho Lee, Kang-Ho Ahn, Il Je Yu
With the rapid development of nanotechnology as one of the most important technologies in the 21(st) century, interest in the safety of consumer products containing nanomaterials is also increasing. Evaluating the nanomaterial release from products containing nanomaterials is a crucial step in assessing the safety of these products, and has resulted in several international efforts to develop consistent and reliable technologies for standardizing the evaluation of nanomaterial release. In this study, the release of nanomaterials from products containing nanomaterials is evaluated using a chamber system that includes a condensation particle counter, optical particle counter, and sampling ports to collect filter samples for electron microscopy analysis...
November 22, 2016: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/27910693/characterization-of-compact-toroid-injection-during-formation-translation-and-field-penetration
#6
T Matsumoto, T Roche, I Allfrey, J Sekiguchi, T Asai, H Gota, M Cordero, E Garate, J Kinley, T Valentine, W Waggoner, M Binderbauer, T Tajima
We have developed a compact toroid (CT) injector system for particle refueling of the advanced beam-driven C-2U field-reversed configuration (FRC) plasma. The CT injector is a magnetized coaxial plasma gun (MCPG), and the produced CT must cross the perpendicular magnetic field surrounding the FRC for the refueling of C-2U. To simulate this environment, an experimental test stand has been constructed. A transverse magnetic field of ∼1 kG is established, which is comparable to the C-2U axial magnetic field in the confinement section, and CTs are fired across it...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27910580/analysis-of-magnetically-immersed-electron-guns-with-non-adiabatic-fields
#7
Alexander Pikin, James G Alessi, Edward N Beebe, Deepak Raparia, John Ritter
Electron diode guns, which have strongly varying magnetic or electric fields in a cathode-anode gap, were investigated in order to generate laminar electron beams with high current density using magnetically immersed guns. By creating a strongly varying radial electric field in a cathode-anode gap of the electron gun, it was demonstrated that the optical properties of the gun can be significantly altered, which allows the generation of a laminar, high-current electron beam with relatively low magnetic field on the cathode...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27909652/percutaneous-transpedicular-lumbar-endoscopy-a-case-report
#8
Priyank Uniyal, Gun Choi, Bhushan Khedkkar
INTRODUCTION: Since Kambin introduced the concept of percutaneous transforaminal disc surgery in 1973, there has been numerous advances in the field of spine endoscopy and the concept of central debulking of the disc has changed to targeted fragmentectomy and disc preservation. The lumbar disc fragments which are down migrated and to the medial aspect of the pedicle are extremely challenging to deal by transforaminal approach even after foraminoplasties and by various other approaches...
2016: International Journal of Spine Surgery
https://www.readbyqxmd.com/read/27909562/educating-restaurant-owners-and-cooks-to-lower-their-own-sodium-intake-is-a-potential-strategy-for-reducing-the-sodium-contents-of-restaurant-foods-a-small-scale-pilot-study-in-south-korea
#9
Sohyun Park, Heeseung Lee, Dong-Il Seo, Kwang-Hwan Oh, Taik Gun Hwang, Bo Youl Choi
BACKGROUND/OBJECTIVES: This study was conducted to evaluate the feasibility of a sodium reduction program at local restaurants through nutrition education and examination of the health of restaurant owners and cooks. SUBJECTS/METHODS: The study was a single-arm pilot intervention using a pre-post design in one business district with densely populated restaurants in Seoul, South Korea. The intervention focused on improving nutrition behaviors and psychosocial factors through education, health examination, and counseling of restaurant personnel...
December 2016: Nutrition Research and Practice
https://www.readbyqxmd.com/read/27904758/penetrating-thoracic-spinal-cord-injury-with-ice-pick-extending-into-the-aorta-a-technical-note-and-review-of-the-literature
#10
Rani Nasser, Jonathan Nakhla, Saadat Sharif, Merritt Kinon, Reza Yassari
BACKGROUND: Penetrating spinal cord injuries pose a great challenge to both patients and the treating physicians. Although the overall incidence of penetrating spinal cord injury is the highest in the military, the ubiquity of guns in our society continues to make penetrating spinal cord injury prevalent in the civilian population. These types of injuries are particularly complicated because, beyond the trauma to the neural elements and supporting structures, other organs can be affected and a team approach is required for successful treatment...
2016: Surgical Neurology International
https://www.readbyqxmd.com/read/27904716/is-anterior-bridge-plating-for-mid-shaft-humeral-fractures-a-suitable-option-for-patients-predominantly-involved-in-overhead-activities-a-functional-outcome-study-in-athletes-and-manual-laborers
#11
Abhishek S Mahajan, Young Gun Kim, Jae Hwa Kim, Prashanth D'sa, Azhar Lakhani, Hyun Soo Ok
BACKGROUND: To assess the functional and radiological outcomes of minimally invasive anterior bridge plating (ABP) for mid-shaft humerus fractures in patients predominantly involved in overhead activities (athletes and manual laborers). METHODS: Forty-eight patients fulfilling inclusion criteria were treated with ABP at a level-I trauma center using a 4.5-mm dynamic/locking compression plate and followed for a period of 1 year. Functional outcome was assessed using the Constant, Mayo elbow, and Disabilities of the Arm, Shoulder and Hand (DASH) scores...
December 2016: Clinics in Orthopedic Surgery
https://www.readbyqxmd.com/read/27903141/does-the-second-amendment-protect-the-gun-rights-of-persons-with-mental-illness
#12
Paul S Appelbaum
Under federal law, persons who have been involuntarily hospitalized for psychiatric reasons are permanently barred from gun possession. That policy was challenged in 2012 by a Michigan man who had been committed 25 years earlier and who was blocked in 2011 from buying a gun. Considering his claim, the Sixth Circuit held that people with mental illness are not categorically excluded from Second Amendment protection and that an irreversible lifetime ban was unconstitutional. Although many mental health organizations and practitioners favor gun restrictions, they oppose discriminatory treatment of persons with mental illness, creating ambivalence about the decision, which presages greater involvement of mental health professionals in decisions regarding gun rights restoration...
December 1, 2016: Psychiatric Services: a Journal of the American Psychiatric Association
https://www.readbyqxmd.com/read/27902476/stromal-p16-expression-is-significantly-increased-in-endometrial-carcinoma
#13
Gun Yoon, Chang Won Koh, Nara Yoon, Ji-Ye Kim, Hyun-Soo Kim
p16 is a negative regulator of cell proliferation and is considered a tumor suppressor protein. Alterations in p16 protein expression are associated with tumor development and progression. However, the p16 expression status in the peritumoral stroma has not been investigated in the endometrium. Therefore, we evaluated stromal p16 expression in different types of endometrial lesions using immunohistochemistry. Differences in the p16 expression status according to the degree of malignancy and histological type were analyzed...
November 25, 2016: Oncotarget
https://www.readbyqxmd.com/read/27902211/flavobacterium-eburneum-sp-nov-isolated-from-reclaimed-saline-land-soil
#14
Woon Mo Hwang, Dohak Kim, Keunsoo Kang, Tae-Young Ahn
A novel Gram-stain-negative, motile by gliding, and aerobic bacterial strain, designated SA31T, was isolated from reclaimed saline land soil near a lake in Taean-gun, South Korea. Cells of the isolate formed ivory-colored colonies. Growth occurred at 10-35 ºC (optimum 25-30 ºC), pH 6.0-9.0 (optimum pH 7.0-7.5), and 0-2.0 % (w/v) NaCl (optimum 0 %). Based on similarities of 16S rRNA gene sequences, strain SA31T was mostly affiliated with the genus Flavobacterium, exhibiting the highest sequence similarities with Flavobacterium palustre S44T (96...
October 12, 2016: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/27902181/pedobacter-lycopersici-sp-nov-isolated-from-rhizosphere-of-tomato-plant-solanum-lycopersicum-l
#15
Hayoung Cho, Jae-Hyung Ahn, Hang-Yeon Weon, Jae-Ho Joa, Soon-Wo Kwon, Soo-Jin Kim
A Gram-staining-negative, rod-shaped, white-colored bacterium, designated strain T16R-88T, was isolated from a rhizosphere soil sample collected in Buyeo-gun of Chungcheongnam-do, South Korea. A phylogenetic tree based on 16S rRNA gene sequences showed that strain T16R-88T formed a lineage within the genus Pedobacter. It showed the highest sequence similarities with Pedobacter ginsengisoli Gsoil 104T (97.4%), Pedobacter nutrimenti J22T (97.2%), Pedobacter nyackensis NWG-II14T (97.1%), 'Pedobacter seoulensis' THG-G12T (97...
October 7, 2016: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/27899331/comparison-of-7t-and-3t-mri-in-patients-with-moyamoya-disease
#16
Byeong Ho Oh, Hyeong Cheol Moon, Hyeon Man Baek, Youn Joo Lee, Sang Woo Kim, Young Jai Jeon, Gun Seok Lee, Hong Rae Kim, Jai Ho Choi, Kyung Soo Min, Mou Seop Lee, Young Gyu Kim, Dong Ho Kim, Won Seop Kim, Young Seok Park
Magnetic resonance imaging and magnetic resonance angiography (MRI/MRA) are widely used for evaluating the moyamoya disease (MMD). This study compared the diagnostic accuracy of 7Tesla (T) and 3T MRI/MRA in MMD. In this case control study, 12 patients [median age: 34years; range (10-66years)] with MMD and 12 healthy controls [median age: 25years; range (22-59years)] underwent both 7T and 3T MRI/MRA. To evaluate the accuracy of MRI/MRA in MMD, five criteria were compared between imaging systems of 7T and 3T: Suzuki grading system, internal carotid artery (ICA) diameter, ivy sign, flow void of the basal ganglia on T2-weighted images, and high signal intensity areas of the basal ganglia on time-of-flight (TOF) source images...
November 27, 2016: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/27898298/estimation-of-visibility-of-phase-contrast-with-extraction-voltages-for-field-emission-gun-electron-microscopes
#17
Xing Meng
Estimation was made for visibility of phase contrast with varying extraction voltages. The resulting decay rates of visibility show that images with low image contrast from cryo EM will be seriously impacted with high extraction voltages.
November 19, 2016: Ultramicroscopy
https://www.readbyqxmd.com/read/27895401/her2-induced-metastasis-is-mediated-by-akt-jnk-emt-signaling-pathway-in-gastric-cancer
#18
Yiseul Choi, Young San Ko, Jinju Park, Youngsun Choi, Younghoon Kim, Jung-Soo Pyo, Bo Gun Jang, Douk Ho Hwang, Woo Ho Kim, Byung Lan Lee
AIM: To investigated the relationships between HER2, c-Jun N-terminal kinase (JNK) and protein kinase B (AKT) with respect to metastatic potential of HER2-positive gastric cancer (GC) cells. METHODS: Immunohistochemistry was performed on tissue array slides containing 423 human GC specimens. Using HER2-positve GC cell lines SNU-216 and NCI-N87, HER2 expression was silenced by RNA interference, and the activations of JNK and AKT were suppressed by SP600125 and LY294002, respectively...
November 7, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/27893892/gun-violence-and-firearm-safety-in-medical-school-curricula-missed-opportunities-to-improve-patient-health
#19
Arianna F Yanes
No abstract text is available yet for this article.
November 28, 2016: JAMA Internal Medicine
https://www.readbyqxmd.com/read/27892470/vertical-magnetic-separation-of-circulating-tumor-cells-for-somatic-genomic-alteration-analysis-in-lung-cancer-patients
#20
Chang Eun Yoo, Jong-Myeon Park, Hui-Sung Moon, Je-Gun Joung, Dae-Soon Son, Hyo-Jeong Jeon, Yeon Jeong Kim, Kyung-Yeon Han, Jong-Mu Sun, Keunchil Park, Donghyun Park, Woong-Yang Park
Efficient isolation and genetic analysis of circulating tumor cells (CTCs) from cancer patients' blood is a critical step for clinical applications using CTCs. Here, we report a novel CTC-isolation method and subsequent genetic analysis. CTCs from the blood were complexed with magnetic beads coated with antibodies against the epithelial cell adhesion molecule (EpCAM) and separated vertically on a density-gradient medium in a modified well-plate. The recovery rate of model CTCs was reasonable and the cell purity was enhanced dramatically when compared to those parameters obtained using a conventional magnetic isolation method...
November 28, 2016: Scientific Reports
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