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https://www.readbyqxmd.com/read/28534835/emulsion-based-intradermal-delivery-of-melittin-in-rats
#1
Sang Mi Han, Se Gun Kim, Sok Cheon Pak
Bee venom (BV) has long been used as a traditional medicine. The aim of the present study was to formulate a BV emulsion with good rheological properties for dermal application and investigate the effect of formulation on the permeation of melittin through dermatomed rat skin. A formulated emulsion containing 1% (w/v) BV was prepared. The emulsion was compared with distilled water (DW) and 25% (w/v) N-methyl-2-pyrrolidone (NMP) in DW. Permeation of melittin from aqueous solution through the dermatomed murine skin was evaluated using the Franz diffusion cells...
May 19, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28534018/hyperthermic-intrathoracic-chemotherapy-with-cisplatin-for-ovarian-cancer-with-pleural-metastasis
#2
Su Youn Jun, Yang Ki Seok, Tomoyasu Kato, Da Som Chun, Yoon Hee Lee, Gun Oh Chong, Yoon Soon Lee, Young Lae Cho, Dae Gy Hong
Intrathoracic metastasis of ovarian cancer has poor prognosis regardless of treatment modality. Recent development of surgical techniques and the new concept of direct infusion of chemotherapeutic agents with hyperthermia could help with the treatment of disseminated diseases in ovarian cancer. Using video-assisted thoracoscopic surgery and intracavitary chemotherapy with hyperthermia, we tried hyperthermic intrathoracic chemotherapy for a case of stage IV high-grade serous ovarian cancer with pleural metastasis...
May 2017: Obstetrics & Gynecology Science
https://www.readbyqxmd.com/read/28532991/estimating-population-density-for-disease-risk-assessment-the-importance-of-understanding-the-area-of-influence-of-traps-using-wild-pigs-as-an-example
#3
Amy J Davis, Bruce Leland, Michael Bodenchuk, Kurt C VerCauteren, Kim M Pepin
Population density is a key driver of disease dynamics in wildlife populations. Accurate disease risk assessment and determination of management impacts on wildlife populations requires an ability to estimate population density alongside management actions. A common management technique for controlling wildlife populations to monitor and mitigate disease transmission risk is trapping (e.g., box traps, corral traps, drop nets). Although abundance can be estimated from trapping actions using a variety of analytical approaches, inference is limited by the spatial extent to which a trap attracts animals on the landscape...
June 1, 2017: Preventive Veterinary Medicine
https://www.readbyqxmd.com/read/28532084/incorporation-of-bmp-2-loaded-collagen-conjugated-bcp-granules-in-calcium-phosphate-cement-based-injectable-bone-substitutes-for-improved-bone-regeneration
#4
Gun Hee Lee, Preeti Makkar, Kallyanshis Paul, ByongTaek Lee
The objective of the present study was to incorporate surface modified porous multichannel BCP granule into CPC to enhance its in vivo biodegradation and bone tissue growth. The multichannel BCP granule (15wt%) was first coated with collagen subsequent to BMP-2 loading (ccMCG-B). It was then embedded into CPC to form CPC-ccMCG-B system. The newly developed CPC-ccMCG-B system was then examined for SEM, EDX, XRD, setting time, compressive strength, injectability, pH change, BMP-2 release, in vitro as well as in vivo studies and further compared with CPC...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28530507/the-reliability-and-sensitivity-of-performance-measures-in-a-novel-pace-bowling-test
#5
Simon A Feros, Warren B Young, Brendan J O'Brien
OBJECTIVES: Evaluate the reliability and sensitivity of performance measures in a novel pace bowling test. METHODS: Thirteen male amateur club fast bowlers completed a novel pace bowling test on two separate occasions, 4-7 days apart. Participants delivered 48 balls (8 overs), at five targets on a suspended sheet, situated behind a 'live' batter who stood in a right-handed and left-handed stance for an equal amount of deliveries. Delivery instruction was frequently changed, with all deliveries executed in a pre-planned sequence...
May 22, 2017: International Journal of Sports Physiology and Performance
https://www.readbyqxmd.com/read/28529523/epidemiological-and-clinical-parameters-features-of-patients-with-clonorchiasis-in-the-geum-river-basin-republic-of-korea
#6
Hee-Eun Shin, Myoung-Ro Lee, Jung-Won Ju, Byong-Suk Jeong, Mi-Yeoun Park, Keoung-Sook Lee, Shin-Hyeong Cho
This study was conducted to evaluate the infection rates of Clonorchis sinensis and laboratory findings in infected people. The 3,167 fecal samples, from nine villages in Okcheon-gun, were examined.
2017: Interdisciplinary Perspectives on Infectious Diseases
https://www.readbyqxmd.com/read/28528742/patterns-of-gun-deaths-across-us-counties-1999-2013
#7
Bindu Kalesan, Sandro Galea
PURPOSE: We examined the socio-demographic distribution of gun deaths across 3143 counties in 50 United States' states to understand the spatial patterns and correlates of high and low gun deaths. METHODS: We used aggregate counts of gun deaths and population in all counties from 1999 to 2013 from the Centers for Disease Control and Prevention's Wide-ranging Online Data for Epidemiologic Research (WONDER). We characterized four levels of gun violence, as distinct levels of gun death rates of relatively safe, unsafe, violent, and extremely violent counties, based on quartiles of 15-year county-specific gun death rates per 100,000 and used negative binomial regression models allowing clustering by state to calculate incidence rate ratios and 95% confidence intervals (95% CIs)...
April 27, 2017: Annals of Epidemiology
https://www.readbyqxmd.com/read/28527100/parents-expectations-of-high-schools-in-firearm-violence-prevention
#8
Erica Payton, Jagdish Khubchandani, Amy Thompson, James H Price
Firearm violence remains a significant problem in the US (with 2787 adolescents killed in 2015). However, the research on school firearm violence prevention practices and policies is scant. Parents are major stakeholders in relation to firearm violence by youths and school safety in general. The purpose of this study was to examine what parents thought schools should be doing to reduce the risk of firearm violence in schools. A valid and reliable questionnaire was mailed to a national random sample of 600 parents who had at least one child enrolled in a public secondary school (response rate = 47%)...
May 19, 2017: Journal of Community Health
https://www.readbyqxmd.com/read/28525644/risk-factors-and-clinical-outcomes-of-breakthrough-yeast-bloodstream-infections-in-patients-with-hematological-malignancies-in-the-era-of-newer-antifungal-agents
#9
Si-Hyun Kim, Jae-Ki Choi, Sung-Yeon Cho, Hyo-Jin Lee, Sun Hee Park, Su-Mi Choi, Dong-Gun Lee, Jung-Hyun Choi, Jin-Hong Yoo, Jong-Wook Lee
Although yeast bloodstream infections (BSIs) are increasingly being reported in patients with hematological malignancies undergoing antifungal therapy, clinical information regarding breakthrough infections is scarce. The aim of this study was to determine the risk factors for and clinical outcomes of breakthrough yeast BSIs in patients with hematological malignancies in the era of newer antifungal agents. Between 2011 and 2014, all consecutive patients with hematological malignancies who developed yeast BSIs were included in a case-control study wherein breakthrough infections (cases) and de novo infections (controls) were compared...
May 19, 2017: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
https://www.readbyqxmd.com/read/28524045/assessment-of-itch-and-sensory-characteristics-in-patients-with-hand-eczema
#10
Sung-Min Park, Jeong-Min Kim, Gun-Wook Kim, Won-Jeong Kim, Hoon-Soo Kim, Hyung-Chang Ko, Moon-Bum Kim, Byung-Soo Kim
No abstract text is available yet for this article.
May 19, 2017: European Journal of Dermatology: EJD
https://www.readbyqxmd.com/read/28523090/penetrating-craniomaxillofacial-injury-caused-by-a-pneumatic-nail-gun
#11
Kevin Jae Choi, Marisa Ann Ryan, Tracy Cheng, David Powers
Craniomaxillofacial injuries can be complex, requiring a multidisciplinary approach. The primary survey is always the first step in trauma management prior to proceeding with further evaluation and treatment. A 26-year-old man presented with a penetrating nail gun injury through the oral and nasal cavities. He did not present in extremis but required elective endotracheal intubation for intraoperative assessment and treatment. Airway management was enhanced by the use of lingual nerve and inferior alveolar nerve blocks via the Vazirani-Akinosi technique to maintain spontaneous respiration while the tongue was distracted from the palate...
June 2017: Craniomaxillofacial Trauma & Reconstruction
https://www.readbyqxmd.com/read/28522589/identification-of-cancer-targeted-tropomyosin-inhibitors-and-their-synergy-with-microtubule-drugs
#12
Mark A Currier, Justine R Stehn, Ashleigh Swain, Duo Chen, Jeff Hook, Eleanor Eiffe, Andrew Heaton, David Brown, Brooke Nartker, David W Eaves, Nina Kloss, Herbert Treutlein, Jun Zeng, Irina B Alieva, Vera B Dugina, Edna C Hardeman, Peter W Gunning, Timothy P Cripe
Actin filaments, with their associated tropomyosin polymers, and microtubules are dynamic cytoskeletal systems regulating numerous cell functions. While anti-microtubule drugs are well-established, anti-actin drugs have been more elusive. We previously targeted actin in cancer cells by inhibiting the function of a tropomyosin isoform enriched in cancer cells, Tpm3.1, using a first-in-class compound, TR100. Here, we screened over 200 other anti-tropomyosin analogues for anti-cancer and on-target activity using a series of in vitro cell-based and biochemical assays...
May 18, 2017: Molecular Cancer Therapeutics
https://www.readbyqxmd.com/read/28520488/firearm-legislation-and-fatal-police-shootings-in-the-united-states
#13
Aaron J Kivisto, Bradley Ray, Peter L Phalen
OBJECTIVES: To examine whether stricter firearm legislation is associated with rates of fatal police shootings. METHODS: We used a cross-sectional, state-level design to evaluate the effect of state-level firearm legislation on rates of fatal police shootings from January 1, 2015, through October 31, 2016. We measured state-level variation in firearm laws with legislative scorecards from the Brady Center, and for fatal police shootings we used The Counted, an online database maintained by The Guardian...
May 18, 2017: American Journal of Public Health
https://www.readbyqxmd.com/read/28516339/holding-manufacturers-of-defective-firearms-to-account-does-restricting-liability-lawsuits-violate-the-second-amendment
#14
Neil J Nusbaum
Judicial and statutory developments since 2005 have placed considerable roadblocks in the way of legal efforts against the epidemic of gun violence in the United States. Although the Second Amendment is most often cited by those opposed to gun control, it offers a potential opportunity to be invoked in support of harm minimization.
May 17, 2017: Journal of Community Health
https://www.readbyqxmd.com/read/28515222/zebrafish-models-for-functional-and-toxicological-screening-of-nanoscale-drug-delivery-systems-promoting-preclinical-applications
#15
Keon Yong Lee, Gun Hyuk Jang, Cho Hyun Byun, Minhong Jeun, Peter Searson, Kwan Hyi Lee
Preclinical screening with animal models is an important initial step in clinical translation of new drug delivery systems. However, establishing efficacy, biodistribution, and biotoxicity of complex, multicomponent systems in small animal models can be expensive and time consuming. Zebrafish models represent an alternative for preclinical studies of nanoscale drug delivery systems. These models allow easy optical imaging, large sample size, and organ-specific studies, and hence an increasing number of preclinical studies are employing zebrafish models...
May 17, 2017: Bioscience Reports
https://www.readbyqxmd.com/read/28510330/rhesus-macaque-ipsc-generation-and-maintenance
#16
Ravi Chandra Yada, So Gun Hong, Yongshun Lin, Thomas Winkler, Cynthia E Dunbar
The rhesus macaque (Macaca mulatta) is physiologically and phylogenetically similar to humans, and therefore represents an invaluable model for the pre-clinical assessment of the safety and feasibility of iPSC-derived cell therapies. The use of an excisable polycistronic lentiviral STEMCCA vector to reprogram rhesus fibroblasts or bone marrow stromal cells (BMSCs) into RhiPSCs is described. After reprogramming, the pluripotency transgenes can be removed by transient expression of Cre, leaving a residual genetic tag that may be useful for identification of RhiPSC-derived tissues in vivo...
May 16, 2017: Current Protocols in Stem Cell Biology
https://www.readbyqxmd.com/read/28509378/evaluation-of-the-skin-phototoxicity-and-photosensitivity-of-honeybee-venom
#17
Sang Mi Han, In Phyo Hong, Soon Ok Woo, Se Gun Kim, He Rye Jang, Kwan Kyu Park
OBJECTIVE: Bee (Apis mellifera L.) venom (BV) has been used as a cosmetic ingredient owing to its anti-aging, anti-inflammatory, and antibacterial effects. The aim of this study was to assess the skin safety of BV. METHODS: For this purpose, skin phototoxicity and sensitization tests were conducted in healthy male Hartley guinea pigs. The animals were divided into three groups (n=5) for the phototoxicity test: G1 (negative control), G2 (BV gel treatment), and G3 (positive control)...
May 16, 2017: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/28507426/performance-of-high-school-students-in-a-laparoscopic-training-program
#18
Scott Furer, Sarah Alam, James Rosser
BACKGROUND AND OBJECTIVES: We hypothesized that high school students can be subjected to the same laparoscopic surgical training curriculum used by surgeons and successfully complete it. The goal of this study was to evaluate the appropriateness of early training in minimally invasive surgical techniques. METHODS: Thirteen high school students, ages 15-18, participated in the validated Top Gun Surgeon Laparoscopic Skills and Suturing program. The students performed 3 preparatory drills 10 times each...
April 2017: JSLS: Journal of the Society of Laparoendoscopic Surgeons
https://www.readbyqxmd.com/read/28503399/functional-dependence-of-resonant-harmonics-on-nanomechanical-parameters-in-dynamic-mode-atomic-force-microscopy
#19
Federico Gramazio, Matteo Lorenzoni, Francesc Pérez-Murano, Enrique Rull Trinidad, Urs Staufer, Jordi Fraxedas
We present a combined theoretical and experimental study of the dependence of resonant higher harmonics of rectangular cantilevers of an atomic force microscope (AFM) as a function of relevant parameters such as the cantilever force constant, tip radius and free oscillation amplitude as well as the stiffness of the sample's surface. The simulations reveal a universal functional dependence of the amplitude of the 6th harmonic (in resonance with the 2nd flexural mode) on these parameters, which can be expressed in terms of a gun-shaped function...
2017: Beilstein Journal of Nanotechnology
https://www.readbyqxmd.com/read/28502906/anti-inflammatory-effects-of-forsythia-suspensa-in-dextran-sulfate-sodium-induced-colitis
#20
Youn-Hwan Hwang, Dong-Gun Kim, Wei Li, Hye Jin Yang, Nam-Hui Yim, Jin Yeul Ma
ETHNOPHARMACOLOGICAL RELEVANCE: Forsythia suspensa Fructus (FS) is used to treat various inflammatory disorders in traditional Oriental medicine, including gastrointestinal diseases, but its therapeutic potential in ulcerative colitis is unclear. Thus, we investigated any potential therapeutic effects of FS against intestinal inflammation and the bioactive constituents in FS. MATERIALS AND METHODS: After the induction of colitis using 3% dextran sulfate sodium, FS (100mg/kg/day) was administered orally during the experimental period...
May 11, 2017: Journal of Ethnopharmacology
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