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Gunilla Pousette Lundgren, Gun-Inger Morling Vestlund, Göran Dahllöf
OBJECTIVES: Amelogenesis imperfecta (AI) is a rare, genetically determined defect in enamel mineralization. Several problems are associated with AI: hypersensitivity, wear, restorations requiring replacement, gingivitis, aesthetic problems, and social avoidance. We conducted a randomized controlled trial of crown therapy in young individuals with AI showing excellent results. This study reports results from a long-term-follow-up with focus on quality, longevity and adverse events. METHODS: The RCT included 27 patients (aged 11-22 years) with severe AI in need of crown therapy and used a split-mouth technique...
July 9, 2018: Journal of Dentistry
Hilda W Chan, Andrea M Russell, Meredith Y Smith
BACKGROUND: Poor-quality patient drug information has been identified as a major cause of preventable medication errors in the United States. The US Food and Drug Administration (FDA) has the authority to require marketing authorization holders of medicinal products to implement risk evaluation and mitigation strategies (REMS) to ensure that the benefits of a drug or biological product outweigh its risks. Aside from medication guides, no research has been conducted to assess the quality of patient-targeted REMS materials, including whether, and to what extent, patients find these materials understandable and actionable...
July 13, 2018: Pharmacoepidemiology and Drug Safety
Carral-Santander Irving Enrique, Acón-Ramírez Dhariana, Soberón-Ventura Vidal, Peñaranda-Henao Carlos Felipe, Wheelock-Gutiérrez Lorena, García-Aguirre Gerardo
Purpose: To report the conservative management of a penetrating ocular trauma caused by a nail gun with a six-month follow up. Observations: A 21 year-old healthy female suffered an ocular penetrating trauma with a nail gun. She presented with a metallic foreign body that partially entered her left eye through the nasal sclera via pars plana, 3 mm posterior to the limbus, but did not reach the retina. Surgical removal of the foreign body and closure of the scleral wound, without vitrectomy, was performed 16 h after the injury...
September 2018: American Journal of Ophthalmology Case Reports
Andrea J Romero, Sheri Bauman, Mark Borgstrom, Sei Eun Kim
Latino/a youth have reported the highest rates of suicide attempts compared to White and African American youth for over 40 years. The data from the Youth Risk Behavior Surveillance System (YRBSS) cross-sectional subsamples of Latino/a youth (N = 13,378) at every year of data collection between 2005 and 2015 were examined for bullying, gun carrying, and suicidality. Results indicate that Latina girls are significantly more likely than boys to make a suicide attempt and report more bullying and more cyberbullying, but are less likely to carry a gun...
2018: American Journal of Orthopsychiatry
Woon-Mok Sohn, Byoung-Kuk Na, Shin-Hyeong Cho, Jung-Won Ju, Soon-Won Lee, Won-Seok Seok
To investigate the infection status of zoonotic trematode metacercariae in yellowfin goby, Acanthogobius flavimanus, from coastal areas of the Republic of Korea (Korea), we examined total 344 gobies from 21 localities with an artificial digestion method from 2013 to 2017. The metacercariae of Stictodora lari were most frequently detected in 45.3% goby from 7 localities, i.e., Taean-gun (Chungcheongnam-do), Gochang-gun (Jeollabuk-do), Muan-gun, Shinan-gun, Haenam-gun (Jeollanam-do), Hadong-gun and Goseong-gun (Gyeongsangnam-do)...
June 2018: Korean Journal of Parasitology
Jinfeng Yang, Yoichi Yoshida, Hidehiro Yasuda
Ultrafast electron microscopy (UEM) with femtosecond temporal resolution is a 'dream machine' that has been long envisioned for the study of ultrafast structural dynamics in materials. For this purpose, we developed a prototype UEM with relativistic femtosecond electron pulses generated by a radio-frequency acceleration-based photoemission gun. TEM images of polystyrene latex particles and gold nanoparticles were observed using approximately 100-fs-long electron pulses with energies of 3.1 MeV. The effect of emittance and the number of pulses on the images were investigated...
July 9, 2018: Microscopy
W E Feeman
No abstract text is available yet for this article.
July 2018: Journal of Family Practice
G W S Simanjuntak, G Farinthska, G A M Simanjuntak, W Artini, R Natali
Objective: : To report the risk factors for poor visual outcome in traumatic hyphema. Materials and Methods: A retrospective study was done by collecting data from medical records between January 2011 and December 2015 in Jakarta, Indonesia. Clinical data included initial visual acuity (IVA), final VA at 3 months, slit lamp evaluation with grading of hyphema, intraocular pressure, and fundus findings on direct or indirect ophthalmoscopy. Results: The study included 97 patients, with males showing a preponderance, the ratio being 9:1...
July 2018: Nigerian Journal of Clinical Practice
Hae Lee, Yong-Gun Kim, Heung-Sik Um, Beom-Seok Chang, Si Young Lee, Jae-Kwan Lee
Purpose: The aim of this study was to evaluate the antimicrobial effect of a newly devised toothbrush with light-emitting diodes (LEDs) on Porphyromonas gingivalis attached to sandblasted and acid-etched titanium surfaces. Methods: The study included a control group, a commercial photodynamic therapy (PDT) group, and 3 test groups (B, BL, and BLE). The disks in the PDT group were placed in methylene blue and then irradiated with a diode laser. The B disks were only brushed, the BL disks were brushed with an LED toothbrush, and the BLE disks were placed into erythrosine and then brushed with an LED toothbrush...
June 2018: Journal of Periodontal & Implant Science
Farhan Anwar Khan, Gang Zhao, Yusi Guo, Muhammad Faisal, Jin Chao, Xi Chen, Chenfei He, Harish Menghwar, Rahim Dad, Muhammad Zubair, Changmin Hu, Yingyu Chen, Huanchun Chen, Zhang Rui, Aizhen Guo
Mycoplasma bovis ( M. bovis ) is an important pathogen of cattle. An attenuated live vaccine has recently been developed by this laboratory. However, an effective assay for the differentiation of infected from vaccinated animals (DIVA) is still lacking. Therefore, a comparative immunoproteomics study of the membrane and membrane associated proteins (MAPs) of M. bovis HB0801 and its attenuated strain ( M. bovis -150) was aimed to identify potential antigens for DIVA assay. Triton-X-114 fractionated liposoluble proteins of both the virulent and attenuated strains were separated with 2-DE and proteins reacting with sera against the virulent M...
June 19, 2018: Oncotarget
Sang-Jun Lee, Sumi Oh, Mi-Ja Kim, Gun-Sub Sim, Tae Wha Moon, JaeHwan Lee
Background: Explosive puffing can induce changes in the chemical, nutritional, and sensory quality of red ginseng. The antioxidant properties of ethanolic extracts of red ginseng and puffed red ginseng were determined in bulk oil and oil-in-water (O/W) emulsions. Methods: Bulk oils were heated at 60°C and 100°C and O/W emulsions were treated under riboflavin photosensitization. In vitro antioxidant assays, including 2,2-diphenyl-1-picrylhudrazyl, 2,2'-azinobis-3-ethyl-benzothiazoline-6-sulfonic acid, ferric reducing antioxidant power, total phenolic content, and total flavonoid content, were also performed...
July 2018: Journal of Ginseng Research
Joyce C M Meiring, Nicole S Bryce, Yao Wang, Manuel H Taft, Dietmar J Manstein, Sydney Liu Lau, Jeffrey Stear, Edna C Hardeman, Peter W Gunning
Tropomyosin proteins form stable coiled-coil dimers that polymerize along the α-helical groove of actin filaments [1]. The actin cytoskeleton consists of both co-polymers of actin and tropomyosin and polymers of tropomyosin-free actin [2]. The fundamental distinction between these two types of filaments is that tropomyosin determines the functional capability of actin filaments in an isoform-dependent manner [3-9]. However, it is unknown what portion of actin filaments are associated with tropomyosin. To address this deficit, we have measured the relative distribution between these two filament populations by quantifying tropomyosin and actin levels in a variety of human cell types, including bone (U2OS); breast epithelial (MCF-10A); transformed breast epithelial (MCF-7); and primary (BJpar), immortalized (BJeH), and Ras-transformed (BJeLR) BJ fibroblasts [10]...
June 22, 2018: Current Biology: CB
Byung Min Lee, Jee Suk Chang, Young Up Cho, Seho Park, Hyung Seok Park, Jee Ye Kim, Joo Hyuk Sohn, Gun Min Kim, Ja Seung Koo, Ki Chang Keum, Chang-Ok Suh, Yong Bae Kim
PURPOSE: IBTR! 2.0 nomogram is web-based nomogram that predicts ipsilateral breast tumor recurrence (IBTR). We aimed to validate the IBTR! 2.0 using an external data set. Materials and. METHODS: The cohort consisted of 2,206 patients, who received breast conserving surgery and radiation therapy from 1992 to 2012 at our institution, where wide surgical excision is been routinely performed. Discrimination and calibration were used for assessing model performance. Patients with predicted 10-year IBTR risk based on an IBTR! 2...
June 2018: Radiation Oncology Journal
Roza G Kamiloglu, Monique A M Smeets, Jasper H B de Groot, Gün R Semin
No abstract text is available yet for this article.
July 5, 2018: Chemical Senses
Yeon Hee Park, Kyung-Hun Lee, Joo Hyuk Sohn, Keun Seok Lee, Kyung Hae Jung, Jee-Hyun Kim, Ki Hyeong Lee, Jin Seok Ahn, Tae-Yong Kim, Gun Min Kim, In Hae Park, Sung-Bae Kim, Se Hyun Kim, Hye Sook Han, Young-Hyuck Im, Jin-Hee Ahn, Jung-Yong Kim, Jahoon Kang, Seock-Ah Im
Although the introduction of human epidermal growth factor receptor (HER)2-directed therapy including trastuzumab, pertuzumab, lapatinib, and trastuzumab emtansine (T-DM1) in the treatment of HER2-positive metastatic breast cancers (mBCs) favorably changed the natural history of this disease, most cases of HER2-positive mBC will eventually progress. Poziotinib is an oral pan-HER kinase inhibitor showing potent activity through irreversible inhibition of these kinases. This open-label, multicenter phase II study was designed to evaluate the efficacy and safety of poziotinib monotherapy in patients with HER2-positive mBC who had progressed from more than two HER2-directed therapies...
July 6, 2018: International Journal of Cancer. Journal International du Cancer
Aadil Rahim, Jonathan Baird-Gunning, David E Ashton, Tobias Angstmann, Rajat Lahoria
No abstract text is available yet for this article.
July 2018: Neurohospitalist
Yoon Hee Lee, Min Kyung Kim, Hee Young Moon, Gun Oh Chong, Hyun Jung Lee, Yoon Soon Lee, Ji Young Park, Chan Hyeong Lee, Moon Chang Baek, Dae Gy Hong
BACKGROUND/AIM: This study was designed to identify candidate proteins which can be used for visualization of pelvic autonomic nerve during nerve-sparing surgery. MATERIALS AND METHODS: Both soft tissue and vesical branch of the inferior hypogastric nerve from five women were collected during surgery. These 10 tissue specimens were analysed using liquid chromatography-mass spectrometry (LC-MS) and Human Protein Atlas (HPA) for protein expression. The existence of nerve fibres was confirmed using haematoxylin and eosin (H&E) and anti-S-100 staining...
July 2018: Cancer Genomics & Proteomics
Susan Jaffe
No abstract text is available yet for this article.
June 23, 2018: Lancet
Jan W Eriksson, Per Lundkvist, Per-Anders Jansson, Lars Johansson, Mats Kvarnström, Linda Moris, Tasso Miliotis, Gun-Britt Forsberg, Ulf Risérus, Lars Lind, Jan Oscarsson
AIMS/HYPOTHESIS: The EFFECT-II study aimed to investigate the effects of dapagliflozin and omega-3 (n-3) carboxylic acids (OM-3CA), individually or combined, on liver fat content in individuals with type 2 diabetes and non-alcoholic fatty liver disease (NAFLD). METHODS: This randomised placebo-controlled double-blind parallel-group study was performed at five clinical research centres at university hospitals in Sweden. 84 participants with type 2 diabetes and NAFLD were randomly assigned 1:1:1:1 to four treatments by a centralised randomisation system, and all participants as well as investigators and staff involved in the study conduct and analyses were blinded to treatments...
July 3, 2018: Diabetologia
Ellicott C Matthay, Jessica Galin, Kriszta Farkas, Kara Rudolph, Garen Wintemute, Jennifer Ahern
No abstract text is available yet for this article.
July 3, 2018: Annals of Internal Medicine
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