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https://www.readbyqxmd.com/read/28324267/chemotherapy-induced-irreversible-alopecia-in-early-breast-cancer-patients
#1
Gun Min Kim, Sanghwa Kim, Hyung Seok Park, Jee Ye Kim, Sanggen Nam, Seho Park, Seung Il Kim, DoYoung Kim, Joohyuk Sohn
PURPOSE: The purpose of this work is to determine the prevalence of chemotherapy-induced irreversible alopecia (CIIA), which is defined as an alopecia that exists at least 6 months after completion of chemotherapy and factors affecting CIIA in early breast cancer patients. METHODS: We performed a cross-sectional study. We retrospectively identified breast cancer patients who had received AC (Adriamycin, Cyclophosphamide) or AC-T (AC followed by Taxane) as neoadjuvant or adjuvant chemotherapy...
March 21, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28323539/guns-in-the-home-and-the-possibility-of-aggressive-tendencies-exploring-a-community-sample-of-adolescents-in-low-income-communities
#2
Brad Lian, Beatrice Abiero, Paula Kamara
Firearm violence has been the second leading cause of death among adolescents and young adults in the United States since 2000 and is a major public health concern. But firearms may be related to less lethal forms of violence as well. Here we examine the relationship between the presence of a gun in the home and several behavioral and psychosocial measures related to aggression and violence among adolescents using data from a community-based survey of nearly 2,000 youths living in low-income neighborhoods. Our results indicate that adolescents living in homes where a gun is present display more aggressive attitudes and behaviors than their counterparts living in homes with no gun present...
March 21, 2017: Social Work in Public Health
https://www.readbyqxmd.com/read/28319176/insight-into-the-mechanism-of-action-of-temporin-sha-a-new-broad-spectrum-antiparasitic-and-antibacterial-agent
#3
Zahid Raja, Sonia André, Feten Abbassi, Vincent Humblot, Olivier Lequin, Tahar Bouceba, Isabelle Correia, Sandra Casale, Thierry Foulon, Denis Sereno, Bruno Oury, Ali Ladram
Antimicrobial peptides (AMPs) are promising drugs to kill resistant pathogens. In contrast to bacteria, protozoan parasites, such as Leishmania, were little studied. Therefore, the antiparasitic mechanism of AMPs is still unclear. In this study, we sought to get further insight into this mechanism by focusing our attention on temporin-SHa (SHa), a small broad-spectrum AMP previously shown to be active against Leishmania infantum. To improve activity, we designed analogs of SHa and compared the antibacterial and antiparasitic mechanisms...
2017: PloS One
https://www.readbyqxmd.com/read/28319125/spatio-temporal-patterns-of-gun-violence-in-syracuse-new-york-2009-2015
#4
David A Larsen, Sandra Lane, Timothy Jennings-Bey, Arnett Haygood-El, Kim Brundage, Robert A Rubinstein
Gun violence in the United States of America is a large public health problem that disproportionately affects urban areas. The epidemiology of gun violence reflects various aspects of an infectious disease including spatial and temporal clustering. We examined the spatial and temporal trends of gun violence in Syracuse, New York, a city of 145,000. We used a spatial scan statistic to reveal spatio-temporal clusters of gunshots investigated and corroborated by Syracuse City Police Department for the years 2009-2015...
2017: PloS One
https://www.readbyqxmd.com/read/28316964/the-fixation-method-according-to-the-fracture-type-of-the-greater-trochanter-in-unstable-intertrochanteric-fractures-undergoing-arthroplasty
#5
Doohoon Sun, Byeong-Seop Park, Gun-Il Jang, Bongjoo Lee
PURPOSE: We conducted a study on patients who underwent hip joint arthroplasty because of unstable femur intertrochanteric fractures with greater trochanter bony fragments. After dividing patients into three groups depending on their fracture patterns, we evaluated the clinical and radiological outcomes of different operation methods applied to each of these groups. MATERIALS AND METHODS: Using Evan's classification, we defined an unstable intertrochanteric fracture as those characterized as stage 4 or 5...
March 2017: Hip & Pelvis
https://www.readbyqxmd.com/read/28316903/network-guided-transcranial-magnetic-stimulation-for-depression
#6
Marc J Dubin, Conor Liston, Michael A Avissar, Irena Llieva, Faith M Gunning
PURPOSE OF REVIEW: First, we will identify candidate predictive biomarkers of antidepressant response of TMS based on the neuroimaging literature. Next, we will review the effects of TMS on networks involved in depression. Finally, we will discuss ways in which our current understanding of network engagement by TMS may be used to optimize its antidepressant effect. RECENT FINDINGS: The past few years has seen significant interest in the antidepressant mechanisms of TMS...
March 2017: Current Behavioral Neuroscience Reports
https://www.readbyqxmd.com/read/28315800/comparative-outcomes-of-cortical-screw-trajectory-fixation-and-pedicle-screw-fixation-in-lumbar-spinal-fusion-a-systematic-review-and-meta-analysis
#7
REVIEW
Gun Keorochana, Saran Pairuchvej, Warayos Trathitephun, Alisara Arirachakaran, Pradit Predeeprompan, Jatupon Kongtharvonskul
No abstract text is available yet for this article.
March 15, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28300263/size-specific-emission-in-peptide-capped-gold-quantum-clusters-with-tunable-photoswitching-behavior
#8
Abhishek Baral, Kingshuk Basu, Sirshendu Ghosh, Kalishankar Bhattacharyya, Subhasish Roy, Ayan Datta, Arindam Banerjee
Three different types of fluorescent gold clusters (namely blue, green and red emitting) have been prepared from a gold precursor (chloroauric acid) under moderate conditions in aqueous medium. A cysteine containing dipeptide has been used for the formation of these quantum clusters as this peptide molecule contains a thiol group in the side chain to cap these nascently formed clusters and the free amino and carboxylic moieties assist in water solubility. Thus, the clusters are also environmentally friendly as the capped peptide is made up of only naturally occurring protein amino acids...
March 16, 2017: Nanoscale
https://www.readbyqxmd.com/read/28297270/the-feasibility-of-using-microsoft-kinect-v2-sensors-during-radiotherapy-delivery
#9
David M Edmunds, Sophie E Bashforth, Fatemeh Tahavori, Kevin Wells, Ellen M Donovan
Consumer-grade distance sensors, such as the Microsoft Kinect devices (v1 and v2), have been investigated for use as marker-free motion monitoring systems for radiotherapy. The radiotherapy delivery environment is challenging for such sensors because of the proximity to electromagnetic interference (EMI) from the pulse forming network which fires the magnetron and electron gun of a linear accelerator (linac) during radiation delivery, as well as the requirement to operate them from the control area. This work investigated whether using Kinect v2 sensors as motion monitors was feasible during radiation delivery...
November 2016: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28297145/5q14-3-microdeletions-a-contiguous-gene-syndrome-with-capillary-malformation-arteriovenous-malformation-syndrome-and-neurologic-findings
#10
Sung-Min Park, Jeong-Min Kim, Gun-Wook Kim, Hoon-Soo Kim, Byung-Soo Kim, Moon-Bum Kim, Hyun-Chang Ko
Deletions within chromosome region 5q14.3q15 have been associated with a spectrum of disorders including developmental delay, hypotonia, absent speech, mild facial dysmorphism, seizures, and brain anomalies. Some cases of concomitant neurologic abnormalities and cutaneous vascular malformation associated with 5q14.3 deletion have been reported. Previously reported cases had similar features, including multiple capillary malformations, and neurologic abnormalities, including epilepsy, hypotonia, and developmental delay...
March 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/28294383/the-association-between-gun-ownership-and-statewide-overall-suicide-rates
#11
Michael D Anestis, Claire Houtsma
An extensive body of research has demonstrated an association between gun ownership and suicide that extends beyond the effects of a range of covariates. We aimed to expand on extant research by examining the extent to which gun ownership predicts statewide overall suicide rates beyond the effects of demographic, geographic, religious, psychopathological, and suicide-related variables. By extending the list of covariates utilized, considering those covariates simultaneously, and using more recent data, we sought to present a more stringent test...
March 13, 2017: Suicide & Life-threatening Behavior
https://www.readbyqxmd.com/read/28292279/the-quality-of-severe-mental-disorder-diagnoses-in-a-national-health-registry-as-compared-to-research-diagnoses-based-on-structured-interview
#12
Ragnar Nesvåg, Erik G Jönsson, Inger Johanne Bakken, Gun Peggy Knudsen, Thomas D Bjella, Ted Reichborn-Kjennerud, Ingrid Melle, Ole A Andreassen
BACKGROUND: Utilization of diagnostic information from national patient registries rests on the quality of the registered diagnoses. We aimed to investigate the agreement and consistency of diagnoses of psychotic and bipolar disorders in the Norwegian Patient Registry (NPR) compared to structured interview-based diagnoses given as part of a clinical research project. METHODS: Diagnostic data from NPR were obtained for the period 01.01.2008-31.12.2013 for all patients who had been included in the Thematically Organized Psychosis (TOP) study between 18...
March 14, 2017: BMC Psychiatry
https://www.readbyqxmd.com/read/28291866/long-term-safety-and-efficacy-of-achieving-very-low-levels-of-low-density-lipoprotein-cholesterol-a-prespecified-analysis-of-the-improve-it-trial
#13
Robert P Giugliano, Stephen D Wiviott, Michael A Blazing, Gaetano M De Ferrari, Jeong-Gun Park, Sabina A Murphy, Jennifer A White, Andrew M Tershakovec, Christopher P Cannon, Eugene Braunwald
Importance: In the Improved Reduction of Outcomes: Vytorin Efficacy International Trial, intensive low-density lipoprotein cholesterol (LDL-C)-reducing therapy with ezetimibe/simvastatin compared with simvastatin alone was associated with a significant reduction in cardiovascular events in 18 144 patients after acute coronary syndrome. The safety of very low LDL-C levels over the long-term is unknown. Objective: To assess the safety and clinical efficacy of achieving a very low (<30 mg/dL) level of LDL-C at 1 month using data from the Improved Reduction of Outcomes: Vytorin Efficacy International Trial...
March 14, 2017: JAMA Cardiology
https://www.readbyqxmd.com/read/28290922/the-peace-gun-and-the-eradication-of-smallpox
#14
Gwen Nelmes
No abstract text is available yet for this article.
March 2017: Military Medicine
https://www.readbyqxmd.com/read/28290127/jumping-the-gun-faster-response-latencies-to-deceptive-questions-in-a-realistic-scenario
#15
Tessa Mapala, Lara Warmelink, Sally A Linkenauger
Most theories of lie detection assume that lying increases cognitive load, resulting in longer response latencies during questioning. However, the studies supporting this theory are typically laboratory-based, in settings with no specific validity in security contexts. Consequently, using virtual reality (VR), we investigated how response latencies were influenced in an ecologically valid environment of interest to security professionals. In a highly realistic airport security terminal presented in VR, a security officer asked participants yes/no questions about their belongings...
March 13, 2017: Psychonomic Bulletin & Review
https://www.readbyqxmd.com/read/28289633/improved-gait-speed-after-robot-assisted-gait-training-in-patients-with-motor-incomplete-spinal-cord-injury-a-preliminary-study
#16
Seungwon Hwang, Hye-Ri Kim, Zee-A Han, Bum-Suk Lee, Soojeong Kim, Hyunsoo Shin, Jae-Gun Moon, Sung-Phil Yang, Mun-Hee Lim, Duk-Youn Cho, Hayeon Kim, Hye-Jin Lee
OBJECTIVE: To evaluate the clinical features that could serve as predictive factors for improvement in gait speed after robotic treatment. METHODS: A total of 29 patients with motor incomplete spinal cord injury received 4-week robot-assisted gait training (RAGT) on the Lokomat (Hocoma AG, Volketswil, Switzerland) for 30 minutes, once a day, 5 times a week, for a total of 20 sessions. All subjects were evaluated for general characteristics, the 10-Meter Walk Test (10MWT), the Lower Extremity Motor Score (LEMS), the Functional Ambulatory Category (FAC), the Walking Index for Spinal Cord Injury version II (WISCI-II), the Berg Balance Scale (BBS), and the Spinal Cord Independence Measure version III (SCIM-III) every 0, and 4 weeks...
February 2017: Annals of Rehabilitation Medicine
https://www.readbyqxmd.com/read/28287066/neoagarohexaose-activates-dendritic-cells-via-toll-like-receptor-4-leading-to-stimulation-of-natural-killer-cells-and-enhancement-of-antitumor-immunity
#17
Moon Hee Lee, Jong-Hwa Jang, Gun Young Yun, Min-Goo Lee, Tae Heung Kang, Hee Dong Han, Seung Jun Lee, Hyuk Soon Kim, Wahn Soo Choi, Won Sun Park, Yeong-Min Park, In Duk Jung
β-agarase cleaves β-1,4 linkages of agar to produce neoagarooligosaccharides (NAO), which are associated with various physiological functions. However, the immunological functions of NAO are still unclear. In this study, we demonstrated that β-agarase DagA-produced neoagarohexaose (DP6), one among the many NAO products, promotes the maturation of dendritic cells (DCs) by Toll-like receptor 4 (TLR4). DP6 directly and indirectly enhanced the activation of natural killer (NK) cells in a TLR4-dependent manner in vitro and in vivo...
March 13, 2017: BMB Reports
https://www.readbyqxmd.com/read/28286940/comparison-of-tolvaptan-treatment-between-patients-with-the-siadh-and-congestive-heart-failure-a-single-center-experience
#18
Gun Ha Park, Chang Min Lee, Jae Won Song, Moon Chan Jung, Jwa Kyung Kim, Young Rim Song, Hyung Jik Kim, Sung Gyun Kim
Background/Aims: Tolvaptan is a very effective treatment for hypervolemic or euvolemic hyponatremia. We compared the clinical efficacy of and response to tolvaptan in patients with the syndrome of inappropriate antidiuretic hormone secretion (SIADH) and congestive heart failure (CHF). Methods: We retrospectively reviewed the medical records of 50 patients (SIADH, n = 30; CHF, n = 20) who were prescribed tolvaptan between July 2013 and October 2015. Tolvaptan was prescribed when the serum sodium level was < 125 mmol/L and the standard treatment failed...
March 13, 2017: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/28286923/maintenance-therapies-in-indolent-lymphomas-should-recent-data-change-the-standard-of-care
#19
REVIEW
Michael T Tees, Ian W Flinn
The overall benefit of maintenance therapy for patients with an indolent lymphoma continues to go unanswered. A myriad of variables contribute to the lack of clear clinical guidance. First, the disease course is slow and treatment may not be required for years, requiring a long follow-up to prospectively study. Second, due to the long lag time from study initiation to conclusion, many of the induction therapies used at the onset of the study may not be favored at present, providing a conclusion that cannot be reconciled with current clinical practice...
March 2017: Current Treatment Options in Oncology
https://www.readbyqxmd.com/read/28286104/akr1b10-inhibitory-selaginella-tamariscina-extract-and-amentoflavone-decrease-the-growth-of-a549-human-lung-cancer-cells-in-vitro-and-in-vivo
#20
Yu-Jin Jung, Eun Ha Lee, Chang Gun Lee, Ki-Jong Rhee, Woo-Suk Jung, Yongsoo Choi, Cheol-Ho Pan, Kyungsu Kang
ETHNOPHARMACOLOGICAL RELEVANCE: Selaginella tamariscina (P.Beauv.) Spring is a traditional medicinal plant used to treat various human diseases, including cancer, in Asia. The detailed molecular mechanism underlying the anti-cancer effects of this plant and the anti-cancer action of the combinatorial treatment of S. tamariscina and doxorubicin have not yet been investigated. AIM OF THE STUDY: We evaluated the inhibitory activity of S. tamariscina extract (STE) and its major compound, amentoflavone, on human aldo-keto reductase family 1B10 (AKR1B10), which is a detoxification enzyme involved in drug resistance, to evaluate their anti-cancer effects and their potential as adjuvant agents for doxorubicin cancer chemotherapy...
March 9, 2017: Journal of Ethnopharmacology
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