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https://www.readbyqxmd.com/read/28636236/assessment-of-silibinin-as-a-potential-antifungal-agent-and-investigation-of-its-mechanism-of-action
#1
Dae Gyu Yun, Dong Gun Lee
Silibinin, which is derived from Silybum marianum (milk thistle), has used as a traditional remedy for liver or biliary disorders and known to have superior antioxidant activity. In addition, silibinin was recently reported to have antifungal effect related to fungal apoptosis against Candida albicans and the interest in the therapeutic effect is increasing. In this study, we found another mode of antifungal action of silibinin and its antibiofilm activity on C. albicans. To investigate influence on fungal plasma membrane, propidium iodide and bis-(1, 3-dibutylbarbituric acid) trimethineoxonol [DiBAC4 (3)] assay were primarily carried out...
June 21, 2017: IUBMB Life
https://www.readbyqxmd.com/read/28633513/gram-scale-production-of-ginsenoside-f1-using-a-recombinant-bacterial-%C3%AE-glucosidase
#2
Dong-Shan An, Chang-Hao Cui, Muhammad Zubair Siddiqi, Hong Shan Yu, Feng-Xie Jin, Song-Gun Kim, Wan-Taek Im
Naturally occurring ginsenoside F1 (20-O-β-D-glucopyranosyl-20(S)-protopanaxatriol) is rare. Here, we produced gram-scale quantities of ginsenoside F1 from a crude protopanaxatriol saponin mixture comprised mainly of Re and Rg1 through enzyme-mediated biotransformation using recombinant β-glucosidase (BgpA) cloned from a soil bacterium, Terrabacter ginsenosidimutans Gsoil3082(T). In a systematic, step-by-step process, the concentrations of substrate, enzyme, and NaCl were determined for maximal production of F1...
June 21, 2017: Journal of Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28632556/watertight-sealing-without-lumbar-drainage-for-incidental-ventral-dural-defect-in-transthoracic-spine-surgery-a-retrospective-review-of-53-cases
#3
Sang-Hyeop Jeon, Sang-Ho Lee, Yi Sheng Tsang, Tag-Geun Jung, Ki-Hyoung Moon, Gun Choi, Ketan D Dilip
STUDY DESIGN: A retrospective review. OBJECTIVES: To evaluate the therapeutic efficacy of the triple layer closure technique to establish watertight sealing without diversion of lumbar drainage, in preventing persistent incidental subarachnoid-pleural fistula and other neurological complications related to excessive drainage of cerebrospinal fluid (CSF) after dural defect in transthoracic ossified posterior longitudinal ligament (OPLL) surgery. SUMMARY OF BACKGROUND DATA: CSF leakage into the pleural cavity leads to unfavorable conditions for natural healing of incidental durotomy due to the negative pressure environment of the pleural space and lack of wound healing around the bony cavity near the decompressed spinal cord...
July 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28632138/monitoring-lung-contusion-in-a-porcine-polytrauma-model-using-eit-an-application-study
#4
Susana Aguiar Santos, Carlos Castelar Wembers, Klemens Horst, Roman Pfeifer, Tim-Philipp Simon, Hans-Christoph Pape, Frank Hildebrand, Michael Czaplik, Steffen Leonhardt, Daniel Teichmann
Lung contusion is the most common lung injury following blunt chest trauma which, in turn, is associated with high mortality rates (Gavelli et al., 2002). Lung contusion is characterized by hemorrhage and edema with consecutively reduced compliance. In this study, unilateral lung contusion and other traumata were induced in 12 pigs by using a bolt gun machine. To investigate the pathophysiological consequences of lung contusion, information on clinical parameters was collected and monitored regularly while animals were additionally monitored with electrical impedance tomography (EIT) before trauma, and at 4, 24, 48 and 72 h after polytrauma...
June 20, 2017: Physiological Measurement
https://www.readbyqxmd.com/read/28631138/college-student-attitudes-towards-smart-guns-results-from-a-nationwide-survey
#5
Lacey N Wallace, Kaylin C Dunn
Existing studies focusing on "smart" guns, weapons that can only be fired by an authorized user, have focused largely on overall views towards the topic. Little is known about how views differ within key demographics or why Americans feel positively or negatively towards smart guns. This study used data from a nationwide web survey of 520 college students to address these concerns. Multinomial regression was used to identify patterns of smart gun preference in quantitative data. Respondents' open-ended reasoning for their views was examined through common themes and descriptive statistics...
June 19, 2017: Journal of Community Health
https://www.readbyqxmd.com/read/28630118/childhood-firearm-injuries-in-the-united-states
#6
Katherine A Fowler, Linda L Dahlberg, Tadesse Haileyesus, Carmen Gutierrez, Sarah Bacon
OBJECTIVES: Examine fatal and nonfatal firearm injuries among children aged 0 to 17 in the United States, including intent, demographic characteristics, trends, state-level patterns, and circumstances. METHODS: Fatal injuries were examined by using data from the National Vital Statistics System and nonfatal injuries by using data from the National Electronic Injury Surveillance System. Trends from 2002 to 2014 were tested using joinpoint regression analyses. Incident characteristics and circumstances were examined by using data from the National Violent Death Reporting System...
June 19, 2017: Pediatrics
https://www.readbyqxmd.com/read/28630031/response-to-david-s-article-on-the-use-of-pellet-guns-in-kashmir
#7
Ratna Magotra
I am distressed by the political inclination of the journal reflected in publishing the article by Siddarth David in a recent issue of Indian Journal of Medical Ethics. The journal has tried to redeem its image by publishing a counterview by Ravindra Ghooi. I feel more voices need to be heard on the utter unsuitability of David's comments on the use of pellet guns by security forces in Kashmir in a medical ethics journal.
June 13, 2017: Indian Journal of Medical Ethics
https://www.readbyqxmd.com/read/28627522/dot1l-safeguards-cartilage-homeostasis-and-protects-against-osteoarthritis
#8
Silvia Monteagudo, Frederique M F Cornelis, Carolina Aznar-Lopez, Ploi Yibmantasiri, Laura-An Guns, Peter Carmeliet, Frédéric Cailotto, Rik J Lories
Osteoarthritis is the most prevalent and crippling joint disease, and lacks curative treatment, as the underlying molecular basis is unclear. Here, we show that DOT1L, an enzyme involved in histone methylation, is a master protector of cartilage health. Loss of DOT1L disrupts the molecular signature of healthy chondrocytes in vitro and causes osteoarthritis in mice. Mechanistically, the protective function of DOT1L is attributable to inhibition of Wnt signalling, a pathway that when hyper-activated can lead to joint disease...
June 19, 2017: Nature Communications
https://www.readbyqxmd.com/read/28624036/firearm-injuries-due-to-legal-intervention-in-children-and-adolescents-a-national-analysis
#9
Noor Joudi, Jun Tashiro, Samuel Golpanian, Sarah A Eidelson, Eduardo A Perez, Juan E Sola
BACKGROUND: Firearm injuries related to legal intervention have come under scrutiny because of recent events. METHODS: The Kids' Inpatient Database (1997-2012) was searched for firearm injuries due to legal interventions (International Classification of Diseases, ninth revision, Clinical Modification E970) requiring inpatient admission in children aged <20 y. Cases were weighted to provide national estimates. The Brady Campaign criteria were used to identify lenient versus strict gun law states...
June 15, 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/28620269/cold-steel-weak-flesh-mechanism-masculinity-and-the-anxieties-of-late-victorian-empire
#10
Michael Brown
This article considers the reception and representation of advanced military technology in late nineteenth- and early twentieth-century Britain. It argues that technologies such as the breech-loading rifle and the machine gun existed in an ambiguous relationship with contemporary ideas about martial masculinities and in many cases served to fuel anxieties about the physical prowess of the British soldier. In turn, these anxieties encouraged a preoccupation in both military and popular domains with that most visceral of weapons, the bayonet, an obsession which was to have profound consequences for British military thinking at the dawn of the First World War...
March 15, 2017: Cultural and Social History: the Journal of the Social History Society
https://www.readbyqxmd.com/read/28619245/the-risk-of-metachronous-neoplasia-on-surveillance-colonoscopy-in-young-patients-with-colorectal-neoplasia
#11
Hyun Gun Kim, Young-Seok Cho, Jae Myung Cha, Jeong Eun Shin, Kyeong Ok Kim, Hyo-Joon Yang, Hoon Sup Koo, Young-Eun Joo, Sun-Jin Boo
BACKGROUND AND AIMS: Few prior reports exist that address the appropriate colonoscopy surveillance interval for individuals <50 years old. We compared the risk of metachronous neoplasia between younger (20-49 years) and older (50-54 years) cohorts. METHODS: This multicenter retrospective cohort study compared the incidence of metachronous neoplasia in younger and older cohorts according to baseline risk stratification. Subjects were eligible if they underwent their first colonoscopy between June 2006 and May 2010, and had at least one or more surveillance colonoscopy up to June 2015...
June 12, 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/28618373/structural-changes-in-cell-wall-pectins-during-strawberry-fruit-development
#12
Candelas Paniagua, Nieves Santiago-Doménech, Andrew R Kirby, A Patrick Gunning, Victor J Morris, Miguel A Quesada, Antonio J Matas, José A Mercado
Strawberry (Fragaria × anannasa Duch.) is one of the most important soft fruit. Rapid loss of firmness occurs during the ripening process, resulting in a short shelf life and high economic losses. To get insight into the role of pectin matrix in the softening process, cell walls from strawberry fruit at two developmental stages, unripe-green and ripe-red, were extracted and sequentially fractionated with different solvents to obtain fractions enriched in a specific component. The yield of cell wall material as well as the per fresh weight contents of the different fractions decreased in ripe fruit...
June 2, 2017: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/28617476/fight-the-silencing-of-gun-research
#13
David Hemenway
No abstract text is available yet for this article.
June 13, 2017: Nature
https://www.readbyqxmd.com/read/28617211/-docs-vs-glocks-and-the-regulation-of-physicians-speech
#14
Paul S Appelbaum
Physicians increasingly have recognized the importance of asking patients whether they own firearms and suggesting safe means of storage. Florida's legislature perceived these questions as threats to patients' rights to keep guns and passed a law restricting physicians from making such inquiries. When a number of physicians and their organizations challenged the law in 2011, a six-year odyssey through the courts ensued. In the end, the U.S. 11th Circuit Court of Appeals struck down the statute, recognizing that physicians' free speech rights extend to communications with patients, a decision that may influence other attempts to restrict clinicians' speech...
June 15, 2017: Psychiatric Services: a Journal of the American Psychiatric Association
https://www.readbyqxmd.com/read/28617092/determination-of-the-smoking-gun-of-intent-significance-testing-of-forced-choice-results-in-social-security-claimants
#15
Laurence M Binder, Michael D Chafetz
OBJECTIVE: Significantly below-chance findings on forced choice tests have been described as revealing "the smoking gun of intent" that proved malingering. The issues of probability levels, one-tailed vs. two-tailed tests, and the combining of PVT scores on significantly below-chance findings were addressed in a previous study, with a recommendation of a probability level of .20 to test the significance of below-chance results. The purpose of the present study was to determine the rate of below-chance findings in a Social Security Disability claimant sample using the previous recommendations...
June 15, 2017: Clinical Neuropsychologist
https://www.readbyqxmd.com/read/28613228/rna-seq-reveals-transcriptomic-differences-in-inflamed-and-noninflamed-intestinal-mucosa-of-crohn-s-disease-patients-compared-with-normal-mucosa-of-healthy-controls
#16
Sung Noh Hong, Je-Gun Joung, Joon Seol Bae, Chan Soo Lee, Ja Seol Koo, Soo Jung Park, Jong Pil Im, You Sun Kim, Ji Won Kim, Woong Yang Park, Young-Ho Kim
BACKGROUND: Aberrant gene expression in the gut mucosa might contribute to the initiation and progression of Crohn's disease (CD). RNA sequencing (RNA-seq) provides precise measurements of expression levels of transcripts and their isoforms. The aim of this study was to use RNA-seq to investigate transcriptomic differences and identify significantly differentially expressed transcripts in inflamed and noninflamed intestinal mucosa of CD patients. METHODS: RNA-seq was performed on 13 pairs of inflamed and noninflamed intestinal mucosa from 13 CD patients and on sex-matched normal mucosa of 13 healthy controls...
July 2017: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/28611731/the-genomic-architecture-of-novel-simulium-damnosum-wolbachia-prophage-sequence-elements-and-implications-for-onchocerciasis-epidemiology
#17
James L Crainey, Jacob Hurst, Poppy H L Lamberton, Robert A Cheke, Claire E Griffin, Michael D Wilson, Cláudia P Mendes de Araújo, María-Gloria Basáñez, Rory J Post
Research interest in Wolbachia is growing as new discoveries and technical advancements reveal the public health importance of both naturally occurring and artificial infections. Improved understanding of the Wolbachia bacteriophages (WOs) WOcauB2 and WOcauB3 [belonging to a sub-group of four WOs encoding serine recombinases group 1 (sr1WOs)], has enhanced the prospect of novel tools for the genetic manipulation of Wolbachia. The basic biology of sr1WOs, including host range and mode of genomic integration is, however, still poorly understood...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28610778/a-comparison-between-non-powder-gun-and-powder-gun-injuries-in-a-young-pediatric-population
#18
Jennifer J Freeman, Marielena Bachier-Rodriguez, Jessica Staszak, Alexander Feliz
INTRODUCTION: Non-powder guns (NPG) are viewed as toys for children by the general public. Literature on firearm injuries in the pediatric population is increasing, however there are still large gaps in the published literature regarding NPG. We intended to identify and compare the epidemiology, circumstances of injury and outcomes of children with NPG versus powder-gun injuries (GSW). PATIENTS AND METHODS: We performed a 6-year retrospective analysis of children 0-14 years old treated for NPG and GSW injuries at our level one pediatric trauma center...
May 29, 2017: Injury
https://www.readbyqxmd.com/read/28610362/a-new-species-of-i-cavernocypris-i-hartmann-1964-crustacea-ostracoda-from-caves-in-south-korea
#19
Robin James Smith, Takahiro Kamiya, Yong-Gun Choi, Jimin Lee, Cheon Young Chang
Surveys of caves in South Korea yielded a new species of the ostracod genus Cavernocypris Hartmann, 1964, herein described as Cavernocypris danielopoli Smith & Kamiya n. sp. This is the fifth described species in this widely distributed genus, and can be discriminated from its congeners by the highly triangular shape of the carapace in lateral view, caused by a large dorsal protrusion on the left valve. A second triangular-shaped morphotype was also collected, differing from the first by a lower carapace and less pronounced dorsal protrusion...
May 17, 2017: Zootaxa
https://www.readbyqxmd.com/read/28608928/self-care-management-of-type-1-diabetes-has-improved-in-swedish-schools-according-to-children-and-adolescents
#20
Anna Ottosson Bixo, Karin Åkesson, Rosita Ilvered, Gun Forsander, Stefan Särnblad
AIM: Age-appropriate support for diabetes self-care is essential during school time and we investigated the perceived quality of support children and adolescents received in 2015 and 2008. METHODS: This national study was based on questionnaires answered by children and adolescents aged 6-15 years of age with type 1 diabetes attending schools or preschools in 2008 (n=317) and 2015 (n=570) and separate parental questionnaires. The subjects were recruited by Swedish paediatric diabetes units, with 41/44 taking part in 2008 and 41/42 in 2015...
June 13, 2017: Acta Paediatrica
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