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Ren Iwata, Claudio Pascali, Kazunori Terasaki, Yoichi Ishikawa, Shozo Furumoto, Kazuhiko Yanai
Conversion of aqueous [(18)F]fluoride to reactive [(18)F]fluoride is an important first step in the radiosynthesis of (18)F-labeled compounds by nucleophilic substitution. A versatile method for the rapid preparation of reactive [(18)F]fluoride by the combined use of an Oasis MAX cartridge and a methanolic solution of the Kryptofix 222-KHCO3 complex (K.222/KHCO3) was developed. The latter amount was optimized with the aim to keep it as low as possible while achieving recovery yields of [(18)F]fluoride comparable to those attained with the commonly used QMA cartridge...
April 13, 2017: Applied Radiation and Isotopes
G I Walters, A S Robertson, V C Moore, P S Burge
Background: Acrylic monomers (acrylates), methacrylates and cyanoacrylates all cause asthma by respiratory sensitization. Occupational inhalation exposures occur across a variety of industries including health care and dental work, beauty, laboratory science, assembly and plastic moulding. Aims: To examine notifications of occupational asthma caused by acrylic compounds from a UK-based regional surveillance scheme, in order to highlight prevalent exposures and trends in presentation...
April 20, 2017: Occupational Medicine
Anna M Stecher, Jennifer Yeung, Catrina C Crisp, Rachel N Pauls
OBJECTIVES: Appropriate perineal protection may reduce rates of obstetric anal sphincter injuries (OASIS). We sought to investigate the knowledge and attitudes of obstetrics and gynecology residents concerning perineal protection, OASIS, and episiotomy before and after an educational workshop. METHODS: This was an institutional review board-approved cross-sectional survey study of obstetrics and gynecology residents. Two experts in perineal protection, whose methods have been shown to reduce OASIS by 50%, provided 1 week of education...
April 20, 2017: Female Pelvic Medicine & Reconstructive Surgery
Yang Zheng, Xiuli Xu, Fei Yuan, Meiyi Yao, Shunli Ji, Zhiqiang Huang, Feng Zhang
A sensitive, high-throughput analytical method based on a GC-MS method was established for the simultaneous quantitative determination of two categories of harmful coumarins: simple coumarins (coumarin, 6-methylcoumarin, 7-methoxycoumarin, 3,4-dihydrocoumarin, and 7-ethoxy-4-methylcoumarin) and furocoumarines (psoralen, 8-methoxypsoralen, 5-methoxypsoralen, and trioxysalen). The nine analytes were extracted with ethyl acetate, purified with Oasis HLB solid-phase extraction (SPE) cartridges, and identified and quantitatively determined by GC-MS in selected-ion monitoring mode...
April 20, 2017: Journal of AOAC International
Jennifer Tjia, Jacob N Hunnicutt, Laurie Herndon, Carolyn R Blanks, Kate L Lapane, Susan Wehry
Importance: Off-label antipsychotic prescribing in nursing homes (NHs) is common and is associated with increased risk of mortality in older adults. Prior large-scale, controlled trials in the NH setting failed to show meaningful reductions in antipsychotic use. Objective: To quantify the influence of a large-scale communication training program on NH antipsychotic use called OASIS. Design, Setting, and Participants: This investigation was a quasi-experimental longitudinal study of NHs in Massachusetts enrolled in the OASIS intervention...
April 17, 2017: JAMA Internal Medicine
Kaleb J Duelge, Upul Nishshanka, Hemakanthi G De Alwis
Antibiotics are used in ethanol production to discourage the growth of bacteria that would result in lower ethanol content and a lower quality product. A survey conducted by the FDA (FY 2010 Nationwide Survey of Distillers Grains for Antibiotic Residues, 2009 [1]) revealed that the residues of these antibiotics can remain in the distillers grains (DG) by-product, which is used as an animal feed ingredient. The low levels of antibiotic residues in DG could be a public health concern, as they could lead to antimicrobial resistance...
April 1, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
Marine Rousset, Karine Titier, Stephane Bouchet, Caroline Dutriaux, Anne Pham-Ledard, Sorilla Prey, Mireille Canal-Raffin, Mathieu Molimard
Targeted therapies for cancers are fast-growing therapies. For instance kinase inhibitors such as BRAF inhibitors (BRAFi) and MEK inhibitors (MEKi) are increasingly used to treat malignant melanoma. The metabolic profile of these drugs can result in great interindividual variability, justifying therapeutic drug monitoring (TDM). We describe a rapid and specific method for quantification of 2 BRAFi (vemurafenib, dabrafenib) and 3 MEKi (cobimetinib, trametinib and binimetinib). Chromatography was performed on a Waters Acquity-UPLC system with CORTECS C18+ column, under a gradient of 10% acetic acid in water/acetonitrile...
April 12, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
Souhila Moussouni, Jean-Christophe Pintaud, Yves Vigouroux, Nadia Bouguedoura
Date palm (Phoenix dactyliferaL.) is the mainstay of oasis agriculture in the Saharan region. It is cultivated in a large part of the Mediterranean coastal area of the Sahara and in most isolated oases in the Algerian desert. We sampled 10 oases in Algeria to understand the structure of date palm diversity from the coastal area to a very isolated desert location. We used 18 microsatellite markers and a chloroplast minisatellite to characterize 414 individual palm trees corresponding to 114 named varieties. We found a significant negative inbreeding coefficient, suggesting active farmer selection for heterozygous individuals...
2017: PloS One
Lisa K G Persson, Abelone Sakse, Jens Langhoff-Roos, Hanna Jangö
PURPOSE: To evaluate prevalence and risk factors for long-term anal incontinence in women with two prior vaginal deliveries without obstetric anal sphincter injury (OASIS) and to assess the impact of anal incontinence-related symptoms on quality of life. METHODS: This is a nation-wide cross-sectional survey study. One thousand women who had a first vaginal delivery and a subsequent delivery, both without OASIS, between 1997 and 2008 in Denmark were identified in the Danish Medical Birth Registry...
April 13, 2017: Archives of Gynecology and Obstetrics
Xiaowei Li, Ping Guo, Yawen Shan, Yuebin Ke, Hui Li, Qin Fu, Yingyu Wang, Tianhe Liu, Xi Xia
This work reports the development of a multi-residue method for the identification and quantification of 82 veterinary drugs belonging to different chemical classes in swine waste lagoon. The proposed method applies a solid-phase extraction procedure with Oasis PRiME HLB cartridges that combines isolation of the compounds and sample clean-up in a single step. Analysis is performed by ultra-high performance liquid chromatography-tandem mass spectrometry, in one single injection with a chromatographic run time of only 9...
March 23, 2017: Journal of Chromatography. A
F Previtali, P Bertolazzi, G Felici, E Weitschek
BACKGROUND AND OBJECTIVE: The cause of the Alzheimer's disease is poorly understood and to date no treatment to stop or reverse its progression has been discovered. In developed countries, the Alzheimer's disease is one of the most financially costly diseases due to the requirement of continuous treatments as well as the need of assistance or supervision with the most cognitively demanding activities as time goes by. The objective of this work is to present an automated approach for classifying the Alzheimer's disease from magnetic resonance imaging (MRI) patient brain scans...
May 2017: Computer Methods and Programs in Biomedicine
Yepu Li, Shengli Wang, Daniel Prete, Suyin Xue, Zhongren Nan, Fei Zang, Qian Zhang
Contamination of agricultural soil with high concentrations of fluorine (F) and cadmium (Cd) have raised significant concerns regarding their impacts on human health but the relationship between F and Cd in soil-wheat plant system in an oasis region has not been investigated. This paper aims to study the accumulation and interaction of F and total Cd in the soil-wheat plant system while considering the potential risks of F and Cd to human health. Soil samples were collected from wastewater-irrigated oasis regions, Dongdagou and Xidagou...
April 5, 2017: Science of the Total Environment
Sophia Ait Errayess, Abdellatif Ait Lahcen, Laila Idrissi, Caterina Marcoaldi, Salvatore Chiavarini, Aziz Amine
The authors have developed a sensitive spectrophotometric method for determination of sulfonamide derivatives such as sulfanilamide (SAA), sulfadiazine (SDZ), sulfacetamide (SCT) sulfamethoxazole (SMX), sulfamerazine (SMR), sulfadimethoxine (SDX), sulfamethiazole (SMT) and Sulfathiazole (STZ). This method is based on the Bratton-Marshall reaction, which involves the diazotization of sulfonamides with sodium nitrite under acidic conditions, followed by coupling with N-(1-naphtyl) ethylenediamine dihydrochloride (NED) to form a pink colored compound...
March 28, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
Ying Zhang, Yan Li, Xiao-Juan Zhu, Min Li, Hao-Yu Chen, Xiao-Ling Lv, Jian Zhang
A reliable and accurate method for the determination of seven biogenic amines (BAs) has been developed and validated with Chinese rice wine samples. The BAs were derivatized with dansyl chloride, cleaned up using solid-phase extraction (SPE), and separated by high-performance liquid chromatography (HPLC) coupled with ultraviolet (UV) detection. The optimized derivatization reaction, conducted at pH 9.6 and 60 °C for 30 min, ensured baseline separation and peak symmetry for each BA. SPE clean-up using Oasis MCX cartridges yielded good recovery rates for all BAs and effectively reduced matrix effects...
April 7, 2017: Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
Takahiro Sumimoto, Ryosuke Nakahara, Yuhki Sato, Hiroki Itoh
BACKGROUND: We propose a simple, sensitive, and fast high-performance liquid chromatography ultraviolet detection (HPLC-UV) method for the quantitative determination of bosutinib in human plasma. METHODS: Plasma samples were processed using an Oasis hydrophilic-lipophilic balance extraction cartridge (1 mL, 30 mg). Bosutinib and the internal standard imatinib were separated using a mobile phase of 0.5% Na2 PO4 H2 O (pH 3.5)-acetonitrile-methanol (55:25:20, v/v/v) on a CAPCELL PAK C18 MG II reversed-phase column 250 nm×4...
April 4, 2017: Journal of Clinical Laboratory Analysis
Robin Guibal, Rémy Buzier, Adeline Charriau, Sophie Lissalde, Gilles Guibaud
DGT passive samplers using Oasis(®) HLB or Oasis(®) MAX sorbent were developed for anionic pesticides sampling. They were tested using four model compounds (i.e. bentazon, chlorsulfuron, ioxynil and mecoprop). Polyacrylamide diffusive gel was found to be more suitable than agarose gel for most anionic pesticides sampling. An elution procedure was optimized and diffusion coefficients were determined for quantitative use of the samplers. Depending on the DGT configuration used (HLB or MAX), accuracies better than 30% were demonstrated in laboratory for pH from 3 to 8 and ionic strengths from 10(-2) to 1 M...
May 8, 2017: Analytica Chimica Acta
Faezeh Eslamipour, Farnaz Tajmir Riahi, Milad Etemadi, Alireza Riahi
BACKGROUND: To determine patient orthodontic treatment need, appropriate self-perceived indices are required. The aim of this study was to assess the sensitivity and specificity of esthetic component (AC) of the index of orthodontic treatment need (IOTN), oral esthetic subjective index scale (OASIS), and visual analog scale (VAS) through dental health component (DHC) IOTN as a normative index to determine the more appropriate self-perceived index among young adults. MATERIALS AND METHODS: In this cross-sectional study, a sample of 993 was randomly selected from freshman students of Isfahan University...
January 2017: Dental Research Journal
Angeliki Antonakou, Dimitrios Papoutsis, Karen Henderson, Zahid Qadri, Andrew Tapp
PURPOSE: To identify the incidence of and risk factors for a repeat obstetric anal sphincter injury (OASIS) in women who sustained an OASIS in their first vaginal delivery and have a subsequent vaginal birth. METHODS: Data were collected retrospectively for women having had singleton cephalic presentation vaginal deliveries between 2007 and 2015. Women with breech deliveries, stillbirths, foetal congenital abnormalities and multiple pregnancies were excluded. RESULTS: Over the study period, we identified 11,191 women who had a first vaginal birth, of which 603 (5...
March 24, 2017: Archives of Gynecology and Obstetrics
Barbora Cervinkova, Lenka Kujovska Krcmova, Veronika Sestakova, Dagmar Solichova, Petr Solich
A new, rapid and effective ultra-high-performance liquid chromatography method with mass spectrometry detection is described for the separation and quantification of 8-hydroxy-2-deoxyguanosine, 8-hydroxyguanosine and creatinine in human urine. The present study uses an isotope-labelled internal standard ([(15)N]5-8-hydroxy-2-deoxyguanosine), a BIO core-shell stationary phase and an isocratic elution of methanol and water. Sample preparation of human urine was performed by solid-phase extraction (SPE) on Oasis HLB cartridges with methanol/water 50:50 (v/v) elution...
March 24, 2017: Analytical and Bioanalytical Chemistry
Judith J A E Donners, Kirsten B Kluivers, Jan W de Leeuw, Jeroen van Dillen, Sander M J van Kuijk, Mirjam Weemhoff
INTRODUCTION AND HYPOTHESIS: National and international guidelines do not provide clear recommendations on the mode of delivery in a subsequent pregnancy after obstetric anal sphincter injury (OASI). The aim of this study was to investigate the opinion of gynecologists in The Netherlands on this choice and the extent to which this choice is affected by the gynecologist's characteristics. METHODS: Of 973 gynecologists sent a questionnaire seeking their opinion on the mode of delivery in 16 different case descriptions, 234 (24%) responded...
March 22, 2017: International Urogynecology Journal
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