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https://www.readbyqxmd.com/read/29923028/genomic-convergence-of-locus-based-gwas-meta-analysis-identifies-axin1-as-a-novel-parkinson-s-gene
#1
Mohammad Saeed
Parkinson's disease (PD) is a common, disabling neurodegenerative disorder with significant genetic underpinnings. Multiple genome-wide association studies (GWAS) have been conducted with identification of several PD loci. However, these only explain about 25% of PD genetic risk indicating that additional loci of modest effect remain to be discovered. Association clustering methods such as gene-based tests are more powerful than single-variant analysis for identifying modest genetic effects. Combined with the locus-based algorithm, OASIS, the most significant association signals can be homed in...
June 19, 2018: Immunogenetics
https://www.readbyqxmd.com/read/29921684/enhancing-recognition-of-obstetric-anal-sphincter-injuries-in-six-maternity-units-in-palestine-an-interventional-quality-improvement-study
#2
Hadil Ali-Masri, Sahar Hassan, Khaled Ismail, Kaled Zimmo, Mohammed Zimmo, Erik Fosse, Åse Vikanes, Katariina Laine
OBJECTIVE: To explore the impact of a training intervention on obstetric anal sphincter injuries' (OASIS) detection rate. DESIGN: Prospective quality improvement interventional study. SETTING: Six secondary and tertiary maternity units in Palestine. POPULATION: Women having singleton vaginal births ≥23 weeks' gestation or babies weighing ≥500 g (n=22 922). Caesarean births (n=5431), multiple gestations (n=443) and vaginal births of unregistered perineum status (n=800) were excluded...
June 19, 2018: BMJ Open
https://www.readbyqxmd.com/read/29917078/reported-changes-in-oral-health-related-quality-of-life-in-children-and-adolescents-before-during-and-after-orthodontic-treatment-a-longitudinal-study
#3
Katrien Jaeken, Maria Cadenas de Llano-Pérula, Jurgen Lemiere, Anna Verdonck, Steffen Fieuws, Guy Willems
Objectives: To investigate the changes in oral health-related quality of life (OHRQoL) before, during, and after orthodontic treatment, determine the relationship with the original treatment need and evaluate the influence of self-esteem (SE). Materials and methods: OHRQoL questionnaires were used in an ongoing observational prospective cohort study at baseline (T0), 1 year after start (T1), and 1 month after the end of active orthodontic treatment (T2). Participants were 11-16-year-old at baseline and 215 complete cases were obtained from a total of 498...
June 18, 2018: European Journal of Orthodontics
https://www.readbyqxmd.com/read/29915692/suitable-oasis-scales-under-a-government-plan-in-the-kaidu-konqi-river-basin-of-northwest-arid-region-china
#4
Aihong Fu, Weihong Li, Yaning Chen, Yuting Liu
The Yanqi Basin and the Konqi River Basin of the Kaidu-Konqi River Basin were chosen as the study sites in this paper in order to investigate suitable scales of natural and artificial oases with a specified water resource and water quantity planned by the local government. Combined with remote-sensing images from 2013, water resources in 2013, 2025 and 2035, and weather and socioeconomic data, suitable scales of oases were analyzed. The results showed that: (1) The total available water quantities in the Yanqi Basin and the Konqi River Basin without river base flow, and the input of water into Bosten Lake and Tarim River, over high-, normal and low-flow periods, in 2025 and 2035, were 19...
2018: PeerJ
https://www.readbyqxmd.com/read/29902622/detection-of-sand-encroachment-patterns-in-desert-oases-the-case-of-erg-chebbi-morocco
#5
Arnald Puy, Manuel Herzog, Pedro Escriche, Amou Marouche, Yousef Oubana, Olaf Bubenzer
Desert oases are fragile agrarian areas, very vulnerable to sand encroachment by wind. Ensuring their conservation highly depends on our capacity to identify sand encroachment patterns, e.g. the origin of sand and its spatial distribution in the irrigated plots. Here we show how to tackle this issue using the case study of Erg Chebbi (Morocco), where two oases (Hassilabiad and Merzouga) are surrounded by dunes, Hamada and alluvial sediments from the Wadi Ziz. We combine field interviews with the study of wind dynamics, sediment sampling, Particle Size Distribution (PSD) tests and End-Member Modelling Analysis (EMMA)...
June 11, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29900375/data-on-the-evaluation-of-structural-index-from-aeromagnetic-enhanced-datasets-with-the-application-of-euldph-%C3%AE-semi-automatic-algorithm
#6
John Stephen Kayode, Yusri Yusup
A secondary dataset was generated from the Euldph-λ semi-automatic Algorithm, (ESA) developed to automatically computes various depths to the magnetic anomalies using a primary data set from gridded aeromagnetic data obtained in the study area. Euler Deconvolution techniques, (EDT), was adopted in the identification and definition of the magnetic anomaly source rocks in the study area. The aim is to use the straightforward technique to pinpoint magnetic anomalies at a depth which substantiate mineralization potential of the area...
August 2018: Data in Brief
https://www.readbyqxmd.com/read/29888065/accurate-and-interpretable-intensive-care-risk-adjustment-for-fused-clinical-data-with-generalized-additive-models
#7
Ben J Marafino, R Adams Dudley, Nigam H Shah, Jonathan H Chen
Risk adjustment models for intensive care outcomes have yet to realize the full potential of data unlocked by the increasing adoption of EHRs. In particular, they fail to fully leverage the information present in longitudinal, structured clinical data - including laboratory test results and vital signs - nor can they infer patient state from unstructured clinical narratives without lengthy manual abstraction. A fully electronic ICU risk model fusing these two types of data sources may yield improved accuracy and more personalized risk estimates, and in obviating manual abstraction, could also be used for real-time decision-making...
2018: AMIA Summits on Translational Science Proceedings
https://www.readbyqxmd.com/read/29885253/long-term-outcomes-of-the-stop-traumatic-oasi-morbidity-project-stomp
#8
Maya Basu, Dot Smith
OBJECTIVE: To evaluate long-term sustainability of the Stop Traumatic OASI Morbidity Project (STOMP) in reducing the incidence of obstetric anal sphincter injury (OASI). METHODS: A prospective observational study of women undergoing vaginal delivery at a UK district general hospital between September 1, 2014, and February 28, 2017. The principles of STOMP involve encouraging upright positioning, verbal coaching to avoid expulsive pushing and to slow down delivery, and tactile support to the vertex to judge speed and slow down delivery...
June 9, 2018: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/29875729/childhood-maltreatment-pathological-personality-dimensions-and-suicide-risk-in-young-adults
#9
Giorgio Falgares, Daniela Marchetti, Giovanna Manna, Pasquale Musso, Osmano Oasi, Daniel C Kopala-Sibley, Sandro De Santis, Maria C Verrocchio
Several studies have demonstrated that child maltreatment (psychological, physical, and sexual abuse, and neglect) may be a significant factor in the development of pathological personality traits that increase the risk for suicidal ideation and behavior from adolescence to adulthood. Currently, the challenge is to understand how different forms of early negative experiences render an individual prone to develop specific personality traits and, in turn, be more vulnerable to suicide risk. To understand the relationship between childhood maltreatment and personality dimensions in suicide risk, our study aims to explore the role of self-criticism and dependency, two different pathological personality traits, as potential mediators of the link between different types of childhood maltreatment and suicide risk in young adults...
2018: Frontiers in Psychology
https://www.readbyqxmd.com/read/29870316/first-molecular-identification-and-phylogeny-of-moroccan-anopheles-sergentii-diptera-culicidae-based-on-second-internal-transcribed-spencer-its2-and-cytochrome-c-oxidase-i-coi-sequences
#10
Oumama Benabdelkrim Filali, Mostafa Kabine, Adil El Hamouchi, Meryem Lemrani, Mustapha Debboun, M'hammed Sarih
Anopheles sergentii known as the "oasis vector" or the "desert malaria vector" is considered the main vector of malaria in the southern parts of Morocco. Its presence in Morocco is confirmed for the first time through sequencing of mitochondrial DNA (mDNA) cytochrome c oxidase subunit I (COI) barcodes and nuclear ribosomal DNA (rDNA) second internal transcribed spacer (ITS2) sequences and direct comparison with specimens of A. sergentii of other countries. The DNA barcodes (n = 39) obtained from A...
June 5, 2018: Vector Borne and Zoonotic Diseases
https://www.readbyqxmd.com/read/29845550/contamination-levels-and-health-risk-assessments-of-heavy-metals-in-an-oasis-desert-zone-a-case-study-in-northwest-china
#11
Qingyu Guan, Na Song, Feifei Wang, Liqin Yang, Zeyu Liu
Rapid and extensive social and economic development has caused severe soil contamination by heavy metals in China. The spatial distribution, pollution levels, and health risks of metals were identified in an oasis-desert zone of northwest China. The mean concentrations of six heavy metals exceeded their corresponding background contents, and each metal concentration in farmland samples was higher than that in Gobi samples. Moreover, these heavy metals followed a similar spatial pattern and showed significant positive correlations with each other, indicating that they have the same sources...
May 29, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29844294/supervoxels-based-histon-as-a-new-alzheimer-s-disease-imaging-biomarker
#12
César A Ortiz Toro, Consuelo Gonzalo Martín, Angel García-Pedrero, Ernestina Menasalvas Ruiz
Alzheimer's disease (AD) represents the prevalent type of dementia in the elderly, and is characterized by the presence of neurofibrillary tangles and amyloid plaques that eventually leads to the loss of neurons, resulting in atrophy in specific brain areas. Although the process of degeneration can be visualized through various modalities of medical imaging and has proved to be a valuable biomarker, the accurate diagnosis of Alzheimer's disease remains a challenge, especially in its early stages. In this paper, we propose a novel classification method for Alzheimer's disease/cognitive normal discrimination in structural magnetic resonance images (MRI), based on the extension of the concept of histons to volumetric images...
May 29, 2018: Sensors
https://www.readbyqxmd.com/read/29843563/sub-critical-water-extraction-of-thyreostats-from-bovine-muscle-followed-by-liquid-chromatography-tandem-mass-spectrometry
#13
Silvia Rocchi, Fulvia Caretti, Lucia Mainero Rocca, Virginia Pérez-Fernández, Pierpaolo Tomai, Chiara Dal Bosco, Roberta Curini, Alessandra Gentili
Thyreostats can be used fraudulently to promote a rapid weight increase of breeding animals at low cost. Their severe toxicological effects impose the development of reliable analytical methods to be used in monitoring plans. This work describes an alternative approach to isolate residues of thiouracil, methyl-thiouracil, propyl-thiouracil, phenyl-thiouracil, tapazole and mercaptobenzimidazole from bovine muscle tissue. The developed procedure is based on three steps: i) matrix solid phase dispersion with C18 for the preliminary sample preparation; ii) subcritical water extraction (SWE) at 160°C and 100 bar; iii) clean-up on an Oasis HLB cartridge...
May 29, 2018: Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
https://www.readbyqxmd.com/read/29805832/uplc-ms-ms-method-for-simultaneous-determination-of-three-major-metabolites-of-mequindox-in-holothurian
#14
Huihui Liu, Chuanbo Ren, Dianfeng Han, Hui Huang, Rongjie Zou, Huawei Zhang, Yingjiang Xu, Xianghong Gong, Xiuzhen Zhang, Yanshen Li
This study developed an ultraperformance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) method for the detection of three major metabolites of mequindox, including 3-methyl-quinoxaline-2-carboxylic acid, 1-desoxymequindox, and 1,4-bisdesoxymequindox (MQCA, 1-DMEQ, and BDMEQ), in holothurian. Target analytes were simplified with ultrasound-assisted acidolysis extracted without complicated enzymolysis steps. After that, each sample was centrifuged and purified by an Oasis MAX cartridge. Then, the processed samples were separated and monitored by UPLC-MS/MS...
2018: Journal of Analytical Methods in Chemistry
https://www.readbyqxmd.com/read/29804027/obstetrical-anal-sphincter-injuries-and-symptoms-after-subsequent-deliveries-a-60-patient-study
#15
Carine Fradet-Menard, Julia Deparis, Bertrand Gachon, Joanna Sichitiu, Fabrice Pierre, Xavier Fritel, David Desseauve
INTRODUCTION: More than half of women with a history of prior obstetric anal sphincter injuries (OASIS) will have another pregnancy. Currently, little is known concerning post-partum perineal symptoms in cases of a subsequent vaginal delivery. The aim of this study was to assess the frequency of perineal functional symptoms following a vaginal delivery after OASIS while comparing them to patients who did not have a subsequent delivery. MATERIAL AND METHOD: Retrospective cohort study between January 2000 and December 2011...
May 21, 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29779692/development-and-validation-of-an-uhplc-hrms-ms-assay-for-nine-toxic-alkaloids-from-endophyte-infected-pasture-grasses-in-horse-serum
#16
Wiebke Rudolph, Daniela Remane, Dirk K Wissenbach, Frank T Peters
Endophyte fungi (e.g. Epichloë ssp. and Neotyphodium ssp.) in symbiosis with pasture grasses (e.g. Festuca arundinacaea and Lolium perenne) can produce toxic alkaloids, which are suspected to be involved in equine diseases such as fescue toxicosis, ryegrass staggers, and equine fescue oedema. The aim of this study was, therefore, to develop and validate a quantification method for these and related alkaloids: ergocristine, ergocryptine, ergotamine, ergovaline, lolitrem B, lysergic acid, N-acetylloline, N-formylloline, peramine, and paxilline in horse serum...
May 7, 2018: Journal of Chromatography. A
https://www.readbyqxmd.com/read/29772053/delivery-outcome-after-trial-of-labor-in-nulliparous-women-over-40-years-of-age-a-population-based-study
#17
Victoria Ankarcrona, Daniel Altman, Anna-Karin Wikström, Bo Jacobsson, Sophia Brismar Wendel
INTRODUCTION: An increasing proportion of nulliparous women are over 40 years and labor is more often induced. The aim of this study was to assess delivery outcome in women over 40 years, accounting for the interaction between age and induction. MATERIAL AND METHODS: Population-based study of 1 644 598 nulliparous women with live singleton cephalic term deliveries 1992 to 2011. Risks of intrapartum cesarean section, operative vaginal delivery, obstetric anal sphincter injury (OASIS), and 5-minutes Apgar score <7 were calculated in women ≥40 years with induced or spontaneous labor, and women <40 years with induced labor by unconditional logistic regression, and presented with crude and adjusted odds ratios (aOR) with 95% confidence intervals (95%CI)...
May 17, 2018: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/29768662/immersion-in-water-during-labour-and-birth
#18
REVIEW
Elizabeth R Cluett, Ethel Burns, Anna Cuthbert
BACKGROUND: Water immersion during labour and birth is increasingly popular and is becoming widely accepted across many countries, and particularly in midwifery-led care settings. However, there are concerns around neonatal water inhalation, increased requirement for admission to neonatal intensive care unit (NICU), maternal and/or neonatal infection, and obstetric anal sphincter injuries (OASIS). This is an update of a review last published in 2011. OBJECTIVES: To assess the effects of water immersion during labour and/or birth (first, second and third stage of labour) on women and their infants...
May 16, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29766613/cortical-thickness-estimations-of-freesurfer-and-the-cat12-toolbox-in-patients-with-alzheimer-s-disease-and-healthy-controls
#19
Rene Seiger, Sebastian Ganger, Georg S Kranz, Andreas Hahn, Rupert Lanzenberger
BACKGROUND AND PURPOSE: Automated cortical thickness (CT) measurements are often used to assess gray matter changes in the healthy and diseased human brain. The FreeSurfer software is frequently applied for this type of analysis. The computational anatomy toolbox (CAT12) for SPM, which offers a fast and easy-to-use alternative approach, was recently made available. METHODS: In this study, we compared region of interest (ROI)-wise CT estimations of the surface-based FreeSurfer 6 (FS6) software and the volume-based CAT12 toolbox for SPM using 44 elderly healthy female control subjects (HC)...
May 15, 2018: Journal of Neuroimaging: Official Journal of the American Society of Neuroimaging
https://www.readbyqxmd.com/read/29765702/is-radiographic-progression-in-radiographic-axial-spondyloarthritis-related-to-matrix-metalloproteinase-degradation-of-extracellular-matrix
#20
Anne Sofie Siebuhr, Desirée van der Heijde, Anne-C Bay-Jensen, Morten Asser Karsdal, Robert Landewé, Astrid van Tubergen, Sofia Ramiro
Background: Radiographic axial spondyloarthritis (r-axSpA) is associated with extracellular matrix (ECM) remodelling of affected tissues. We investigated whether there was a relationship between biomarkers of ECM remodelling and 2-year radiographic progression in r-axSpA. Methods: Patients from the Outcome in Ankylosing Spondylitis International Study (OASIS) were included if they had serum, clinical and spinal radiographic assessments available at baseline and 2 years later...
2018: RMD Open
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