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https://www.readbyqxmd.com/read/28214182/opportunistic-autoimmunity-secondary-to-cancer-immunotherapy-oasi-an-emerging-challenge
#1
M Kostine, L Chiche, E Lazaro, P Halfon, C Charpin, D Arniaud, F Retornaz, P Blanco, N Jourde-Chiche, C Richez, C Stavris
With "checkpoint inhibitors" targeting PD1/PD-1-ligands or CTLA-4/CD28 pathways, immunotherapy has profoundly modified therapeutic strategies in oncology. First approved in refractory metastatic neoplasms (melanoma and lung adenocarcinoma), it is now being tested broadly in other cancers and/or as adjuvant treatment. For a significant proportion of patients, immunotherapy is responsible for "immunological" events, identified as Immune-Related Adverse Events (irAEs). Owing to the increasing number of prescriptions, identification and management of specific immunological side effects is crucial and requires close collaboration between oncologists and internists and/or other organ specialists...
February 14, 2017: La Revue de Médecine Interne
https://www.readbyqxmd.com/read/28212505/long-term-validity-of-the-at-risk-mental-state-arms-for-predicting-psychotic-and-non-psychotic-mental-disorders
#2
P Fusar-Poli, G Rutigliano, D Stahl, C Davies, A De Micheli, V Ramella-Cravaro, I Bonoldi, P McGuire
BACKGROUND: The long-term clinical validity of the At Risk Mental State (ARMS) for the prediction of non-psychotic mental disorders is unknown. METHODS: Clinical register-based cohort study including all non-psychotic individuals assessed by the Outreach And Support in South London (OASIS) service (2002-2015). The primary outcome was risk of developing any mental disorder (psychotic or non-psychotic). Analyses included Cox proportional hazard models, Kaplan-Meier survival/failure function and C statistics...
December 6, 2016: European Psychiatry: the Journal of the Association of European Psychiatrists
https://www.readbyqxmd.com/read/28211186/sacral-neuromodulation-compared-with-injection-of-bulking-agents-for-faecal-incontinence-following-obstetric-anal-sphincter-injury-a-randomised-controlled-trial
#3
M Rydningen, T Dehli, T Wilsgaard, A Rydning, M Kumle, R O Lindsetmo, S Norderval
AIM: The purpose of this trial was to compare the effectiveness of sacral neuromodulation (SNM) with a sub-mucosal injection of collagen (Permacol(®) ) in women with faecal incontinence following obstetric anal sphincter injury (OASIS). METHOD: This single blinded randomized controlled trial at two hospital units in Norway included women with faecal incontinence following OASIS. Eligible women who had had a successful percutaneous nerve evaluation were randomly assigned to SNM or Permacol(®) ...
February 17, 2017: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
https://www.readbyqxmd.com/read/28205148/ocular-autoimmune-systemic-inflammatory-infectious-study-oasis-report-4-analysis-and-outcome-of-scleritis-in-an-east-asian-population
#4
Muhammad Amir Bin Ismail, Rachel Hui Fen Lim, Helen Mi Fang, Elizabeth Poh Ying Wong, Ho Su Ling, Wee Kiak Lim, Stephen C Teoh, Rupesh Agrawal
BACKGROUND: The purpose of this study is to evaluate the spectrum of scleritis from database of Ocular Autoimmune Systemic Inflammatory Infectious Study (OASIS) at a tertiary eye referral eye institute in Singapore. Clinical records of 120 patients with scleritis from a database of 2200 patients from Ocular Autoimmune Systemic Inflammatory Infectious Study (OASIS) were reviewed. RESULTS: 56.6% were females, with a mean age of 48.6 ± 15.9 years. 75 (62.5%) had diffuse anterior scleritis, 25 (20...
December 2017: Journal of Ophthalmic Inflammation and Infection
https://www.readbyqxmd.com/read/28198785/evaluation-of-full-field-electroretinogram-reductions-after-ocriplasmin-treatment-results-of-the-oasis-trial-erg-substudy
#5
David G Birch, Matthew S Benz, Daniel M Miller, Andrew N Antoszyk, Joseph Markoff, Petra Kozma, Esmeralda Meunier, Robert C Sergott
PURPOSE: To explore a possible association between full-field electroretinograms with vitreomacular adhesion resolution and best-corrected visual acuity as part of the prospective, randomized, double-masked, sham-controlled Ocriplasmin for Treatment for Symptomatic Vitreomacular Adhesion Including Macular Hole (OASIS) trial studying ocriplasmin. METHODS: The ERG substudy enrolled 62 of 220 OASIS subjects (randomized 2:1) and analyzed full-field electroretinograms and their association with both vitreomacular adhesion resolution and best-corrected visual acuity from baseline through Month 24...
February 14, 2017: Retina
https://www.readbyqxmd.com/read/28183055/equilibrium-partitioning-of-organic-compounds-to-oasis-hlb-%C3%A2-as-a-function-of-compound-concentration-ph-temperature-and-salinity
#6
Yoonah Jeong, Andreas Schäffer, Kilian Smith
Oasis hydrophilic lipophilic balance(®) (Oasis HLB) is commonly employed in solid phase extraction (SPE) of environmental contaminants and within polar organic chemical integrative passive samplers (POCIS). In this study batch experiments were carried out to evaluate the relative affinity of a range of relevant organic pollutants to Oasis HLB in aqueous systems. The influence of sorbate concentration, temperature, pH, and salinity on the equilibrium sorption was investigated. Equilibrium partition ratios (KD) of 28 compounds were determined, ranging over three orders of magnitude from 1...
January 26, 2017: Chemosphere
https://www.readbyqxmd.com/read/28176379/care-solution-effects-on-contact-lens-in-vivo-wettability
#7
Raied Fagehi, E Ian Pearce, Katherine Oliver, Ali A Abusharha, Alan Tomlinson
BACKGROUND: The aim of the study was to evaluate the effect of care solutions on contact lens in vivo wettability using Doane's interferometric technique. METHODS: Thirteen subjects (aged 26.6 ± 6.3 years) participated for contact lens wettability evaluation after soaking in five care solutions namely Opti-Free EverMoist (now called puremoist), Opti-Free Express (Alcon), COMPLETE (AMO), ReNu and Biotrue (Bausch & Lomb). A new pair of lenses was soaked in the solutions for eight hours (prior to wear) or taken directly from pack solutions (as control) and worn by the subjects...
February 8, 2017: Clinical & Experimental Optometry: Journal of the Australian Optometrical Association
https://www.readbyqxmd.com/read/28164580/comparative-study-of-five-commercially-available-saliva-collection-kits-for-dna-extraction
#8
Kathleen Deeley, Jacqueline Noel, Alexandre R Vieira
BACKGROUND: Obtaining DNA samples through saliva samples is becoming more common, and more companies are responding to this demand with saliva collection/DNA extraction kits. METHODS: The University of Pittsburgh's School of Dental Medicine maintains a DNA bank, which our lab helps direct. While we have always used Oragene (DNAGenotek, Kanata, Canada) kits to collect samples in the past, we recently compared 5 alternative kits/methods in an effort to reduce costs while maintaining quality...
September 1, 2016: Clinical Laboratory
https://www.readbyqxmd.com/read/28162101/fasciola-hepatica-infections-in-cattle-and-the-freshwater-snail-galba-truncatula-from-dakhla-oasis-egypt
#9
W M Arafa, A I Hassan, S A M Snousi, Kh M El-Dakhly, P J Holman, T M Craig, S M Aboelhadid
Infection by Fasciola species was investigated in seven districts of Dakhla Oasis, Egypt, through abattoir inspection of cattle livers for adult worms and sedimentation of faecal samples from local cattle to detect Fasciola eggs. In addition, lymnaeid snails collected from the study area were examined microscopically for developmental stages of Fasciola spp. Abattoir inspection revealed that 51 out of 458 cattle livers (11.1%) contained adult flukes, which were identified morphologically as Fasciola hepatica...
February 6, 2017: Journal of Helminthology
https://www.readbyqxmd.com/read/28156616/developing-an-ehealth-intervention-for-cancer-symptom-management-for-rural-residents
#10
Chi Yeung, Keri Nace Mercer, Dorota Bartoczszyk, Todd Papke
: 207 Background: A disproportionate number of late-stage cancer diagnoses occur in rural residents. Paradoxically this population, with an increased need for palliative care, has minimal access to these services. As smartphone and high-speed internet connectivity reaches near universal penetrance across the country, eHealth technologies have the potential to address this palliative care access gap. Oncology Associated Symptoms and Individualized Strategies (OASIS) web-app was developed to provide tailored cancer symptom self-management support and address this gap...
October 9, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28153282/utilizing-online-dual-spe-lc-with-hrms-for-the-simultaneous-quantification-of-amphotericin-b-fluconazole-and-fluorocytosine-in-human-plasma-and-cerebrospinal-fluid
#11
Lihua Qu, Jing Qian, Ping Ma, Zheng Yin
Amphotericin B (AMB), fluconazole (FZ), and fluorocytosine (FC) are recommended for HIV-associated cryptococcal meningitis (CM) patients as preferred antibiotics. This study presents a fast and automated online-dual-solid phase extraction (SPE)-LC coupled with high resolution mass spectrometer (HRMS) method to simultaneously measure the concentrations of AMB, FZ, and FC in human plasma and cerebrospinal fluid (CSF). Automated sample clean-up was performed on the human plasma and CSF samples with stop-flow heart-cutting two dimensional (2D) separation using a online-dual-SPE system, allowing retention and accumulation of AMB, FZ, and carbamazepine (CBZ, Internal standard (IS)) by the Oasis(®)HLB cartridge, and retention and accumulation of FC and 5-methylcytosine hydrochloride (MC, IS) by the HyperSep Hypercarb cartridge respectively...
April 1, 2017: Talanta
https://www.readbyqxmd.com/read/28131588/simplified-solid-phase-extraction-procedure-combined-with-liquid-chromatography-tandem-mass-spectrometry-for-multiresidue-assessment-of-pharmaceutical-compounds-in-environmental-liquid-samples
#12
C Afonso-Olivares, T Čadková, Z Sosa-Ferrera, J J Santana-Rodríguez, L Nováková
To follow the twelve "green analytical chemistry" (GAC) principles, it is necessary to continuously develop analytical extraction and determination methodologies to assess the presence of micropollutants, such as pharmaceuticals, in environmental samples. A reduction in the analysis time and solvent quantity, which is one of the GAC principles, has been achieved through a simplified solid-phase extraction (SPE) procedure combined with high-performance liquid chromatography-tandem mass spectrometry (LC-MS/MS) for the determination of twenty-three pharmaceuticals in liquid environmental samples using N-vinylpyrrolidone-divinylbenzene copolymer (OASIS HLB) cartridges...
January 23, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28124898/chemical-characterization-of-low-molecular-weight-soluble-microbial-products-in-an-anaerobic-membrane-bioreactor
#13
Chinagarn Kunacheva, Chencheng Le, Yan Ni Annie Soh, David C Stuckey
Effluents from wastewater treatment systems contain a variety of organic compounds, including end products from the degradation of influent substrates, nonbiodegradable feed compounds, and soluble microbial products (SMPs) produced by microbial metabolism. It is important to identify the major components of these SMPs to understand what is in wastewater effluents. In this study, physical pretreatments to extract and concentrate low molecular weight SMPs (MW< 580 Da) from effluents were optimized. Liquid-liquid extraction (LLE) of a 200 mL effluent sample showed the best performance using a mixture of n-hexane, chloroform, and dichloromethane (70 mL) for extraction...
February 8, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28111064/a-rapid-uplc-ms-ms-assay-for-eicosanoids-in-human-plasma-application-to-evaluate-niacin-responsivity
#14
Tricia M Miller, Samuel M Poloyac, Kacey B Anderson, Brooke L Waddell, Erik Messamore, Jeffrey K Yao
A rapid and sensitive method using ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) was developed to simultaneously quantify hydroxyeicosatetraenoic (HETE), dihydroxyeicosatrienoic (DiHETrE), epoxyeicosatrienoic acid (EET), and prostaglandin metabolites of arachidonic acid in human plasma. Sample preparation consisted of solid phase extraction with Oasis HLB (30mg) cartridges for all metabolites. Separation of HETEs, EETs, and DiHETrEs was achieved on an Acquity UPLC BEH C18, 1...
January 18, 2017: Prostaglandins, Leukotrienes, and Essential Fatty Acids
https://www.readbyqxmd.com/read/28107701/simultaneous-determination-of-amantadine-rimantadine-and-memantine-in-processed-products-chicken-tissues-and-eggs-by-liquid-chromatography-with-tandem-mass-spectrometry
#15
Yumi Tsuruoka, Takayuki Nakajima, Maki Kanda, Hiroshi Hayashi, Yoko Matsushima, Souichi Yoshikawa, Marie Nagata, Hiroshi Koike, Chieko Nagano, Kotaro Sekimura, Tsuneo Hashimoto, Ichiro Takano, Tetsuya Shindo
A simultaneous determination of amantadine, rimantadine, and memantine in processed products (deep-fried chicken, fried chicken, fried quail egg, and grilled chicken) with liquid chromatography tandem mass spectrometry (LC-MS/MS) was developed. This new method was also applicable for chicken tissue (muscle, liver, and gizzard) and eggs. The chromatographic separation was performed on a Kinetex(®) XB-C18 core-shell technology column using a mobile phase of acetonitrile and 0.1% formic acid in a 10mmol/L ammonium formate solution, resulting in the complete separation of isomers (rimantadine and memantine) and any other obstructive peaks from the sample matrices...
January 11, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28107238/roles-of-the-endoplasmic-reticulum-stress-transducer-oasis-in-ossification-of-the-posterior-longitudinal-ligament
#16
Yu Chen, Haisong Yang, Jinhao Miao, Xiaowei Liu, Xinwei Wang, Deyu Chen
STUDY DESIGN: In vitro molecular research on the posterior longitudinal ligament fibroblasts. OBJECTIVE: To investigate different expression of old astrocyte specifically induced substance (OASIS) between spinal ligament fibroblasts from the patients with ossification of the posterior longitudinal ligament (OPLL) and from non-OPLL patients and demonstrate knockdown of OASIS protein expression by RNA interference inhibiting expression of type I collagen (COL I) in OPLL cells...
February 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28105902/cost-effectiveness-of-using-adjunctive-porcine-small-intestine-submucosa-tri-layer-matrix-compared-with-standard-care-in-managing-diabetic-foot-ulcers-in-the-us
#17
J F Guest, D Weidlich, H Singh, J La Fontaine, A Garrett, C J Abularrage, C R Waycaster
OBJECTIVE: To estimate the cost-effectiveness of using tri-layer porcine small intestine submucosa (SIS; Oasis Ultra) as an adjunct to standard care compared with standard care alone in managing diabetic foot ulcers (DFUs) in the US, from the perspective of Medicare. METHOD: A Markov model was constructed to simulate the management of diabetic neuropathic lower extremity ulcers over a period of one year in the US. The model was used to estimate the cost-effectiveness of initially using adjunctive SIS compared with standard care alone to treat a DFU in the US at 2016 prices...
January 2, 2017: Journal of Wound Care
https://www.readbyqxmd.com/read/28061422/can-we-predict-obstetric-anal-sphincter-injury
#18
Kristina Drusany Starič, Petra Bukovec, Katja Jakopič, Eftim Zdravevski, Vladimir Trajkovik, Adolf Lukanović
OBJECTIVE: The aim of the study was to identify primiparous pregnant women with a higher risk for obstetric anal sphincter injuries (OASIS) based on obstetric characteristics (risk factors). STUDY DESIGN: In the retrospective case control study primiparous women were examined using endoanal ultrasonography (EUS) for OASIS identification 6-12 weeks after delivery. Obstetric characteristics for OASIS were collected from the mothers' medical records. The univariate analysis of maternal (age at delivery, maternal height, weight, BMI), infant (length, weight and head circumference) and birth (pregnancy duration, labour and delivery duration, episiotomy, vacuum extraction and oxytocin augmentation) risk factors, Pearson correlations and information gain were carried out...
December 23, 2016: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28054131/global-and-regional-annual-brain-volume-loss-rates-in-physiological-aging
#19
Sven Schippling, Ann-Christin Ostwaldt, Per Suppa, Lothar Spies, Praveena Manogaran, Carola Gocke, Hans-Jürgen Huppertz, Roland Opfer
The objective is to estimate average global and regional percentage brain volume loss per year (BVL/year) of the physiologically ageing brain. Two independent, cross-sectional single scanner cohorts of healthy subjects were included. The first cohort (n = 248) was acquired at the Medical Prevention Center (MPCH) in Hamburg, Germany. The second cohort (n = 316) was taken from the Open Access Series of Imaging Studies (OASIS). Brain parenchyma (BP), grey matter (GM), white matter (WM), corpus callosum (CC), and thalamus volumes were calculated...
January 4, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/28045130/sex-related-difference-in-human-white-matter-volumes-studied-inspection-of-the-corpus-callosum-and-other-white-matter-by-vbm
#20
Akihiko Shiino, Yen-Wei Chen, Kenji Tanigaki, Atsushi Yamada, Piers Vigers, Toshiyuki Watanabe, Ikuo Tooyama, Ichiro Akiguchi
It has been contended that any observed difference of the corpus callosum (CC) size between men and women is not sex-related but brain-size-related. A recent report, however, showed that the midsagittal CC area was significantly larger in women in 37 brain-size-matched pairs of normal young adults. Since this constituted strong evidence of sexual dimorphism and was obtained from publicly available data in OASIS, we examined volume differences within the CC and in other white matter using voxel-based morphometry (VBM)...
January 3, 2017: Scientific Reports
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