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restrictive lung disease

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https://www.readbyqxmd.com/read/28075489/cough-augmentation-techniques-for-extubation-or-weaning-critically-ill-patients-from-mechanical-ventilation
#1
REVIEW
Louise Rose, Neill Kj Adhikari, David Leasa, Dean A Fergusson, Douglas McKim
BACKGROUND: There are various reasons why weaning and extubation failure occur, but ineffective cough and secretion retention can play a significant role. Cough augmentation techniques, such as lung volume recruitment or manually- and mechanically-assisted cough, are used to prevent and manage respiratory complications associated with chronic conditions, particularly neuromuscular disease, and may improve short- and long-term outcomes for people with acute respiratory failure. However, the role of cough augmentation to facilitate extubation and prevent post-extubation respiratory failure is unclear...
January 11, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28067257/enhanced-tumor-targeting-selectivity-by-modulating-bispecific-antibody-binding-affinity-and-format-valence
#2
Yariv Mazor, Kris F Sachsenmeier, Chunning Yang, Anna Hansen, Jessica Filderman, Kathy Mulgrew, Herren Wu, William F Dall'Acqua
Bispecific antibodies are considered attractive bio-therapeutic agents owing to their ability to target two distinct disease mediators. Cross-arm avidity targeting of antigen double-positive cancer cells over single-positive normal tissue is believed to enhance the therapeutic efficacy, restrict major escape mechanisms and increase tumor-targeting selectivity, leading to reduced systemic toxicity and improved therapeutic index. However, the interplay of factors regulating target selectivity is not well understood and often overlooked when developing clinically relevant bispecific therapeutics...
January 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28062220/sleep-lung-function-and-quality-of-life-in-patients-with-myasthenia-gravis-a-cross-sectional-study
#3
Ezequiel Fernandes Oliveira, Sergio Roberto Nacif, Jessica Julioti Urbano, Anderson Soares Silva, Claudia Santos Oliveira, Eduardo Araujo Perez, Melissa Nunes Polaro, Berenice Cataldo Oliveira Valerio, Roberto Stirbulov, Giuseppe Insalaco, Acary Sousa Bulle Oliveira, Luis Vicente Franco Oliveira
The purpose of this study was to investigate the physiological variables of lung function, respiratory muscle strength, and sleep in clinically stable patients with myasthenia gravis. This was a prospective cross-sectional study conducted in accordance with the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement. Patients adhering to the eligibility criteria were consecutively recruited from the Research Department of Neuromuscular Diseases at the Federal University of Sao Paulo and the Department of Neurology at Santa Casa de Misericordia of Sao Paulo and were referred to the Nove de Julho University Sleep Laboratory (Sao Paulo, Brazil)...
November 25, 2016: Neuromuscular Disorders: NMD
https://www.readbyqxmd.com/read/28058795/transplant-size-mismatch-in-restrictive-lung-disease
#4
Asvin M Ganapathi, Michael S Mulvihill, Brian R Englum, Paul J Speicher, Brian C Gulack, Asishana A Osho, Babatunde A Yerokun, Laurie R Snyder, Duane Davis, Matthew G Hartwig
BACKGROUND: To maximize the benefit of lung transplantation, the effect of size mismatch on survival in lung transplant recipients with restrictive lung disease (RLD) was examined. METHODS: All single and bilateral RLD lung transplants from 1987-2011 in the UNOS Database were identified. Donor pTLC:Recipient pTLC ratio (pTLCr), quantified mismatch. pTLCr was segregated into 5 strata. A Cox proportional hazards model evaluated the association of pTLCr with mortality hazard...
January 6, 2017: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/28056112/association-of-delayed-adjuvant-chemotherapy-with-survival-after-lung-cancer-surgery
#5
Michelle C Salazar, Joshua E Rosen, Zuoheng Wang, Brian N Arnold, Daniel C Thomas, Roy S Herbst, Anthony W Kim, Frank C Detterbeck, Justin D Blasberg, Daniel J Boffa
Importance: Adjuvant chemotherapy offers a survival benefit to a number of staging scenarios in non-small-cell lung cancer. Variable recovery from lung cancer surgery may delay a patient's ability to tolerate adjuvant chemotherapy, yet the urgency of chemotherapy initiation is unclear. Objective: To assess differences in survival according to the time interval between non-small-cell lung cancer resection and the initiation of postoperative chemotherapy to determine the association between adjuvant treatment timing and efficacy...
January 5, 2017: JAMA Oncology
https://www.readbyqxmd.com/read/28046308/su-d-207b-05-robust-intra-tumor-partitioning-to-identify-high-risk-subregions-for-prognosis-in-lung-cancer
#6
J Wu, M Gensheimer, X Dong, D Rubin, S Napel, M Diehn, B Loo, R Li
PURPOSE: To develop an intra-tumor partitioning framework for identifying high-risk subregions from 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) and CT imaging, and to test whether tumor burden associated with the high-risk subregions is prognostic of outcomes in lung cancer. METHODS: In this institutional review board-approved retrospective study, we analyzed the pre-treatment FDG-PET and CT scans of 44 lung cancer patients treated with radiotherapy...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28043612/post-tuberculosis-pulmonary-function-and-noninfectious-pulmonary-disorders
#7
Muhammad Irfan
Tuberculosis (TB) is among the top infectious causes of morbidity and mortality worldwide and is associated with frequent pulmonary damage despite microbiological cure. Patients with treated TB may remain lifelong sufferers of disabling structural and functional sequelae of the disease, which subsequently impair quality of life. Long-term follow-up studies have revealed that many patients with treated pulmonary TB show signs of permanent impairment of their lung function. Impairment is variable in pattern and severity, ranging from none to severe, and shows restrictive, obstructive, or mixed patterns...
December 2016: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/28042972/a-conservative-treatment-of-patent-ductus-arteriosus-in-very-low-birth-weight-infants
#8
J B Letshwiti, J Semberova, K Pichova, E M Dempsey, O M Franklin, J Miletin
BACKGROUND: Treatment of the patent ductus arteriosus (PDA) in the preterm infant remains contentious. There are numerous options of the PDA management from early targeted treatment, late (symptomatic) treatment to no treatment at all. AIMS: To evaluate a three different PDA management approaches in very low birth weight (VLBW) infants. STUDY DESIGN: A retrospective observational time series study of three cohorts of VLBW infants born between 2004 and 2011...
December 30, 2016: Early Human Development
https://www.readbyqxmd.com/read/28034914/the-regulation-of-acute-immune-responses-to-the-bacterial-lung-pathogen-legionella-pneumophila
#9
REVIEW
Andrew Stephen Brown, Chao Yang, Elizabeth Louise Hartland, Ian Richard van Driel
Legionella pneumophila causes Legionnaires' disease, a severe and potentially fatal bacterial pneumonia in immunocompromised individuals. Despite the understanding that a robust inflammatory response is important for control of L. pneumophila infection, our understanding of the network of molecular and cellular events within the lung that function to clear the bacterium is not clearly understood. This review compiles our understanding of the various molecular and cellular pathways stimulated upon infection with L...
December 29, 2016: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/28019009/restrictive-versus-liberal-red-blood-cell-transfusion-strategy-after-hip-surgery-a-decision-model-analysis-of-healthcare-costs
#10
Mario V Fusaro, Nathan D Nielsen, Alexandra Nielsen, Magali J Fontaine, John R Hess, Robert M Reed, Sylvain DeLisle, Giora Netzer
BACKGROUND: Red blood cell transfusion related to select surgical procedures accounts for approximately 2.8 million transfusions in the United States yearly and occurs commonly after hip fracture surgeries. Randomized controlled trials have demonstrated lack of clinical benefit with higher versus lower transfusion thresholds in postoperative hip fracture repair patients with cardiac disease or risk factors for cardiac disease. The economic implications of a higher versus lower hemoglobin (Hb) threshold have not yet been investigated...
December 26, 2016: Transfusion
https://www.readbyqxmd.com/read/28012496/an-autopsy-case-of-bronchiolitis-obliterans-as-a-previously-unrecognized-adverse-event-of-afatinib-treatment
#11
Nobuhiro Kanaji, Yoichi Chiba Md PhD, Akira Sato Md PhD, Masaki Ueno Md PhD, Akira Tadokoro Md PhD, Nobuyuki Kita Md, Tomoya Ishii Md PhD, Naoki Watanabe Md, Norimitsu Kadowaki Md PhD, Shuji Bandoh Md PhD
Interstitial lung disease is a well-known pulmonary adverse event that occurs during epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI) therapy and results in restrictive ventilatory dysfunction. However, obstructive changes such as those associated with bronchiolitis obliterans (BO) have never been reported as adverse events resulting from the use of any approved EGFR-TKI. This report documents an autopsy case of BO that developed during afatinib treatment for adenocarcinoma of the lung...
January 2017: Respiratory Investigation
https://www.readbyqxmd.com/read/28011759/-end-stage-heart-failure-therapy-potential-lessons-from-congenital-heart-disease-from-pulmonary-artery-banding-and-interatrial-communication-to-parallel-circulation
#12
REVIEW
Dietmar Schranz, Hakan Akintuerk, Norbert F Voelkel
The final therapy of 'end-stage heart failure' is orthotopic heart, lung or heart-lung transplantation. However, these options are not available for many patients worldwide. Therefore, novel therapeutical strategies are needed. Based on pathophysiological insights regarding (1) the long-term impact of an obstructive pulmonary outflow tract in neonates with congenitally corrected transposition of the great arteries, (2) the importance of a restrictive versus a non-restrictive atrial septum in neonates born with a borderline left ventricle and (3) the significance of both, a patent foramen ovale and/or open ductus arteriosus for survival of newborns with persistent pulmonary hypertension, the current review introduces some therapeutical strategies that may be applicable to selected patients with heart failure...
December 23, 2016: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/28002595/matrix-metalloproteinase-gene-polymorphisms-and-susceptibility-to-systemic-sclerosis
#13
T F Rech, S B C Moraes, M Bredemeier, J de Paoli, J C T Brenol, R M Xavier, J A B Chies, D Simon
The major pathological hallmark of the systemic sclerosis (SSc) is skin and internal organ fibrosis, which results from normal tissue architecture alterations and extracellular matrix (ECM) protein deposition. ECM components are degraded by matrix metalloproteinases (MMP). Promoter region polymorphisms in MMP genes may influence gene expression, resulting in an imbalance between ECM protein production and degradation. Here, we analyzed MMP1 -1607 1G/2G (rs1799750), MMP3 -1171 5A/6A (rs3025058), and MMP9 -1562 C/T (rs3918242) polymorphisms in relation to susceptibility to SSc and its clinical features...
December 19, 2016: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/27995010/tsukamurella-tyrosinosolvens-bacteremia-with-coinfection-of-mycobacterium-bovis-pneumonia-case-report-and-literature-review
#14
Chang-Hung Chen, Chao-Tai Lee, Tsung-Chain Chang
INTRODUCTION: We describe an immunocompromised patient with Tsukamurella tyrosinosolvens bacteremia and coinfection of Mycobacterium bovis pneumonia. CASE DESCRIPTION: A 75-year-old male was admitted to our hospital complaining of persistent fever with general malaise. His medical history showed that he had diabetes mellitus (HbA1C 9.2%). A chest computed tomography (CT) showed left upper lung consolidation . Two sets of blood culture at admission finally showed Tsukamurella tyrosinosolvens...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27977587/levodopa-reverse-stridor-and-prevent-subsequent-endotracheal-intubation-in-parkinson-disease-patients-with-bilateral-vocal-cord-palsy-a-case-report
#15
Chia-Chan Tsai, Meng-Ni Wu, Li-Min Liou, Yang-Pei Chang
BACKGROUND: Respiratory abnormalities are often overlooked; however, because of their potential comorbidity, they must be analyzed to determine the most effective treatment for patients with Parkinson disease (PD). Among various theories on respiratory abnormalities in PD, "upper airway obstruction" and "restrictive respiratory disorders" are 2 of the most accepted etiologies; both appear to be related to basal ganglia dysfunction. Complex vocal cord muscle dysfunction contributes to stridor, which can be a manifestation of nigrostriatal dopaminergic dysfunction...
December 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27976661/an-approach-to-interpreting-restrictive-spirometric-pattern-results-in-occupational-settings
#16
Federica Tafuro, Massimo Corradi
OBJECTIVES: The aim of this review is to provide an updated overview of definition, epidemiology, diagnostic algorithm and occupational exposures related to abnormal restrictive spirometrical pattern (RSP) in order to improve the correct interpretation of spirometry test results by occupational healthcare providers. METHODS: A review of the scientific English literature of the last 25 years was carried out with MEDLINE and related keywords [(restricti* AND spirometr*) AND occupational]...
December 13, 2016: La Medicina del Lavoro
https://www.readbyqxmd.com/read/27960245/bronchodilators-for-the-prevention-and-treatment-of-chronic-lung-disease-in-preterm-infants
#17
REVIEW
Geraldine Ng, Orlando da Silva, Arne Ohlsson
BACKGROUND: Chronic lung disease (CLD) occurs frequently in preterm infants. Bronchodilators have the potential effect of dilating small airways with muscle hypertrophy. Increased compliance and tidal volume and decreased pulmonary resistance have been documented with the use of bronchodilators in infants with CLD. Therefore, bronchodilators might have a role in the prevention and treatment of CLD. OBJECTIVES: To determine the effect of bronchodilators given as prophylaxis or as treatment for CLD on mortality and other complications of preterm birth in infants at risk for or identified as having CLD...
14, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27957616/developmental-pathways-in-lung-regeneration
#18
REVIEW
Collin T Stabler, Edward E Morrisey
The key processes of lung development have been elucidated in the past several decades, helping to identify and characterize the resident progenitor cells that ultimately generate the mature organ. The adult lung is a complex organ consisting in scores of different cell lineages that are remarkably quiescent in the absence of injury. Despite low cellular turnover, the lung can respond quickly and dramatically to acute damage, with spatially restricted stem and progenitor cells re-entering the cell cycle and differentiating to promote repair...
December 13, 2016: Cell and Tissue Research
https://www.readbyqxmd.com/read/27956734/emphysema-and-airflow-obstruction-in-non-smoking-coal-miners-with-pneumoconiosis
#19
Bülent Altınsoy, İbrahim İlker Öz, Fatma Erboy, Meltem Tor, Figen Atalay
BACKGROUND Accumulating evidence shows that functional impairment in subjects with coal workers' pneumoconiosis (CWP) is principally due to emphysema and airflow obstruction, rather than underlying restrictive mechanisms. However, cigarette smoking has remained a major confounder. The aim of this study was to assess whether coal dust exposure was associated with emphysema and/or airflow obstruction in the absence of smoking history. MATERIAL AND METHODS The subjects evaluated for possible pneumoconiosis between 2013 and 2015 were retrospectively enrolled into this study...
December 13, 2016: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/27938399/adiposity-markers-and-lung-function-in-smokers-a-cross-sectional-study-in-a-mediterranean-population
#20
Mar Sorlí-Aguilar, Francisco Martín-Luján, Gemma Flores-Mateo, Cristina Jardí-Piñana, Estefania Aparicio-Llopis, Josep Basora-Gallisà, Rosa Solà-Alberich
BACKGROUND: The aim of this study was to assess the association of key adiposity markers with lung function in smokers without respiratory disease in a Mediterranean population. METHODS: We performed a cross-sectional study with baseline data from a representative sample of the ESPITAP study in Spain. Participants were 738 smokers (52.3% men) without respiratory disease, aged 35 to 70, selected from 12 primary health care centres. We assessed weight, height, body mass index (BMI), waist circumference (WC) and waist-to-height ratio (WHtR)...
December 9, 2016: BMC Pulmonary Medicine
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