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lactate elevation in pediatrics

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https://www.readbyqxmd.com/read/27698778/scrub-typhus-associated-with-hemophagocytic-lymphohistiocytosis-a-report-of-six-pediatric-patients
#1
Yingkang Jin, Li Huang, Huifeng Fan, Gen Lu, Yi Xu, Zhiyuan Wu
Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening immune disorder that may be inherited or secondary to infection, malignancy or rheumatological disease. The aim of the present study was to highlight the clinical features of scrub typhus-associated HLH in children. A retrospective study was performed on 6 pediatric patients with scrub typhus-associated HLH. For each patient, medical records were reviewed and analyzed, and demographic, clinical and laboratory data and outcomes were collected. The duration of fever prior to admission ranged between 4 and 12 days...
October 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/27596079/-relationship-between-changes-of-increased-amylase-or-lipase-levels-and-pancreas-injury-in-critically-ill-children
#2
(no author information available yet)
OBJECTIVE: To observe the occurrence rate of elevated serum amylase and lipase in critically ill children, to explore the relationship between elevated pancreatic enzymes and pancreatic injury, and the effect of elevated pancreatic enzymes on state of illness and the prognosis. METHOD: The data of cases treated in pediatric intensive care unit(ICU) of 17 children's hospitals were collected prospectively from January 2012 to March 2014 according to the inclusion and exclusion criteria...
September 2016: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
https://www.readbyqxmd.com/read/27503020/clinical-and-molecular-characteristics-in-100-chinese-pediatric-patients-with-m-3243a-g-mutation-in-mitochondrial-dna
#3
Chang-Yu Xia, Yu Liu, Hui Liu, Yan-Chun Zhang, Yi-Nan Ma, Yu Qi
BACKGROUND: Mitochondrial diseases are a group of energy metabolic disorders with multisystem involvements. Variable clinical features present a major challenge in pediatric diagnoses. We summarized the clinical spectrum of m.3243A>G mutation in Chinese pediatric patients, to define the common clinical manifestations and study the correlation between heteroplasmic degree of the mutation and clinical severity of the disease. METHODS: Clinical data of one-hundred pediatric patients with symptomatic mitochondrial disease harboring m...
August 20, 2016: Chinese Medical Journal
https://www.readbyqxmd.com/read/27490602/biomarkers-in-pediatric-cardiac-critical-care
#4
Michele Domico, Meredith Allen
OBJECTIVES: In this review, we discuss the physiology, pathophysiology, and clinical role of troponin, lactate, and B-type natriuretic peptide in the assessment and management of children with critical cardiac disease. DATA SOURCE: MEDLINE, PubMed. CONCLUSION: Lactate, troponin, and B-type natriuretic peptide continue to be valuable biomarkers in the assessment and management of critically ill children with cardiac disease. However, the use of these markers as a single measurement is handicapped by the wide variety of clinical scenarios in which they may be increased...
August 2016: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/27383405/elevated-baseline-cortisol-levels-are-predictive-of-bad-outcomes-in-critically-ill-children
#5
Yael Levy-Shraga, Orit Pinhas-Hamiel, Vered Molina-Hazan, Liran Tamir-Hostovsky, Zeev Motti Eini, Liat Lerner-Geva, Gideon Paret
OBJECTIVE: The definition of an adequate adrenal response in critically ill children continues to be controversial. We aimed to evaluate the cortisol levels at baseline and after adrenocorticotropin (ACTH) stimulation and determine their association to clinical outcome of critically ill children. METHODS: All children who underwent an ACTH test in the pediatric intensive care unit (PICU) in a tertiary medical center between 2006 and 2013 were included in the study...
July 2, 2016: Pediatric Emergency Care
https://www.readbyqxmd.com/read/27316915/french-intensive-care-society-international-congress-r%C3%A3-animation-2016
#6
(no author information available yet)
No abstract text is available yet for this article.
June 2016: Annals of Intensive Care
https://www.readbyqxmd.com/read/27269180/associations-between-inflammatory-cytokines-and-organ-damage-in-pediatric-patients-with-hemophagocytic-lymphohistiocytosis
#7
Shi-Long Yang, Xiao-Jun Xu, Yong-Min Tang, Hua Song, Wei-Qun Xu, Fen-Ying Zhao, Di-Ying Shen
Hemophagocytic lymphohistiocytosis (HLH) is a potentially fatal disease characterized by overwhelming inflammation response and multiple organ damage. Most of the clinical and laboratory manifestations of HLH are thought to be related to hypercytokinemia and organ infiltration with lymphocytes and histiocytes. The aim of this study was to investigate the associations between cytokines and various manifestations of HLH. A total of 105 patients diagnosed with HLH were enrolled in this retrospective study. The information including the patients' demographic characteristics, clinical and laboratory findings at presentation and cytokine data were collected...
September 2016: Cytokine
https://www.readbyqxmd.com/read/27124563/procalcitonin-in-the-early-course-post-pediatric-cardiac-surgery
#8
Robert Zant, Christian Stocker, Luregn Jan Schlapbach, Sara Mayfield, Tom Karl, Andreas Schibler
OBJECTIVE: Procalcitonin has emerged as a promising infection marker, but previous reports from small-sized studies suggest nonspecific elevation of procalcitonin after pediatric heart surgery. As procalcitonin is increasingly used as a marker for infection in the PICU, the aim of this study was to identify factors associated with postoperative procalcitonin elevation and to investigate the role of procalcitonin as an early marker of outcome after cardiac surgery. DESIGN: Prospective observational study...
July 2016: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/27061429/high-serum-april-levels-strongly-correlate-with-disease-severity-in-pediatric-atopic-eczema
#9
Mohamed H Mohamed Ezzat, Ahmed A Mohammed, Rania I H Ismail, Kareem Y A Shaheen
BACKGROUND: Expression of the tumor necrosis factor (TNF) family member APRIL (a proliferation-inducing ligand) is low in normal tissues but is elevated in various autoimmune diseases. OBJECTIVES: This study explored serum APRIL in children with atopic eczema (AE) during flare and quiescence. METHODS: A case-control study including 50 patients with AE and 40 control subjects was conducted. The severity of AE was assessed according to each of the Leicester Sign Score (LSS), the Simple Scoring System (SSS), the SCORing of Atopic Dermatitis (SCORAD) index, and the Objective SCORAD...
September 2016: International Journal of Dermatology
https://www.readbyqxmd.com/read/26821544/study-of-acute-exogenous-lipoid-pneumonia
#10
Gen Lu, Yaping Xie, Li Huang, Zhijie Tong, Zhiwei Xie, Jialu Yu, Peiqiong Wu
OBJECTIVE: To analyze the clinical and imagenological characteristics of acute Exogenous lipoid pneumonia (ELP), explore its risk factors, and assess the potential role of multiple bronchoalveolar lavages (BALs) and steroid therapy in the treatment of children with acute ELP. METHODS: Between May 2011 and July 2014, 33 pediatric patients with pneumonia caused by aspiration of oil-based substances were admitted to the Guangzhou Women and Children's Medical Center, Guangdong, China...
August 2016: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/26714990/vasoactive-drugs-and-hemodynamic-monitoring-in-pediatric-cardiac-intensive-care-an-italian-survey
#11
MULTICENTER STUDY
Alessandra Rizza, Elena Bignami, Alessandro Belletti, Angelo Polito, Zaccaria Ricci, Giuseppe Isgrò, Alessandro Locatelli, Paola Cogo
BACKGROUND: Little is known about practitioner preference, the availability of technology, and variability in practice with respect to hemodynamic monitoring and vasoactive drug use after congenital heart surgery. The aim of this study was to characterize current hospital practices related to the management of low cardiac output syndrome (LCOS) across Italy. METHODS: We issued a 22-item questionnaire to 14 Italian hospitals performing pediatric cardiac surgery. RESULTS: Electrocardiogram, invasive blood pressure, central venous pressure, pulse oximetry, diuresis, body temperature, arterial lactate, and blood gas analysis were identified as routine in hemodynamic monitoring...
January 2016: World Journal for Pediatric & Congenital Heart Surgery
https://www.readbyqxmd.com/read/26555310/simultaneous-acquired-self-limited-hemophagocytic-lymphohistiocytosis-and-kikuchi-necrotizing-lymphadenitis-in-a-16-year-old-teenage-girl-a-case-report-and-review-of-the-literature
#12
Joseph A Sykes, Kamran Badizadegan, Paul Gordon, Dawn Sokol, Marcella Escoto, Irina Ten, Shayan Vyas, Adalberto Torres, Ann-Marie Levine
OBJECTIVES: The aim of this study was to increase education and awareness among pediatric practitioners of possibility of simultaneous hemophagocytic lymphohistiocytosis and Kikuchi-Fujimoto disease/Kikuchi disease occurring in the pediatric population and the diagnostic dilemma it can present. We describe a case presentation of acquired and self-limited simultaneous hemophagocytic lymphohistiocytosis and Kikuchi-Fujimoto disease in a 16-year-old in the United States who presented with fevers, night sweats, and joint pain, along with tiredness and decreased appetite along with pancytopenia and elevated lactate dehydrogenase...
January 16, 2015: Pediatric Emergency Care
https://www.readbyqxmd.com/read/26472950/development-and-evaluation-of-a-guideline-for-monitoring-propylene-glycol-toxicity-in-pediatric-intensive-care-unit-patients-receiving-continuous-infusion-lorazepam
#13
Lizbeth Hansen, Rebecca Lange, Sameer Gupta
OBJECTIVES: To develop and determine the safety of a guideline, by using osmol gap as an indicator of propylene glycol toxicity for pediatric patients receiving continuous infusion lorazepam. METHODS: From existing adult data, a guideline was developed for the use of continuous infusion lorazepam in pediatric critical care patients with recommendations for using osmol gap as an indicator of propylene glycol toxicity. A retrospective medical chart review was performed of patients receiving continuous infusion lorazepam from February 2012 to September 2012 for whom the guideline was used...
September 2015: Journal of Pediatric Pharmacology and Therapeutics: JPPT: the Official Journal of PPAG
https://www.readbyqxmd.com/read/26304458/mice-repeatedly-exposed-to-group-a-%C3%AE-haemolytic-streptococcus-show-perseverative-behaviors-impaired-sensorimotor-gating-and-immune-activation-in-rostral-diencephalon
#14
Simone Macrì, Chiara Ceci, Martina Proietti Onori, Roberto William Invernizzi, Erika Bartolini, Luisa Altabella, Rossella Canese, Monica Imperi, Graziella Orefici, Roberta Creti, Immaculada Margarit, Roberta Magliozzi, Giovanni Laviola
Repeated exposure to Group-A β-Haemolytic Streptococcus (GAS) may constitute a vulnerability factor in the onset and course of pediatric motor disturbances. GAS infections/colonization can stimulate the production of antibodies, which may cross the blood brain barrier, target selected brain areas (e.g. basal ganglia), and exacerbate motor alterations. Here, we exposed developing SJL male mice to four injections with a GAS homogenate and evaluated the following domains: motor coordination; general locomotion; repetitive behaviors; perseverative responses; and sensorimotor gating (pre-pulse inhibition, PPI)...
2015: Scientific Reports
https://www.readbyqxmd.com/read/26116768/pi3k-akt-signaling-mediated-hexokinase-2-expression-inhibits-cell-apoptosis-and-promotes-tumor-growth-in-pediatric-osteosarcoma
#15
Baobiao Zhuo, Yuan Li, Zhengwei Li, Haihui Qin, Qingzeng Sun, Fengfei Zhang, Yang Shen, Yingchun Shi, Rong Wang
Accumulating evidence has shown that PI3K/Akt pathway is frequently hyperactivated in osteosarcoma (OS) and contributes to tumor initiation and progression. Altered phenotype of glucose metabolism is a key hallmark of cancer cells including OS. However, the relationship between PI3K/Akt pathway and glucose metabolism in OS remains largely unexplored. In this study, we showed that elevated Hexokinase-2 (HK2) expression, which catalyzes the first essential step of glucose metabolism by conversion of glucose into glucose-6-phosphate, was induced by activated PI3K/Akt signaling...
August 21, 2015: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/25908988/markedly-elevated-procalcitonin-in-early-postoperative-period-in-pediatric-open-heart-surgery-a-prospective-cohort-study
#16
Etsuko Minami, Shoji Ito, Takeshi Sugiura, Yoshihito Fujita, Hiroshi Sasano, Kazuya Sobue
BACKGROUND: We encountered markedly elevated procalcitonin (PCT) among pediatric patients during the early postoperative period of open heart surgery. The purpose of this study is to investigate what factors are associated with the PCT elevation. METHODS: Fifty-two pediatric patients undergoing cardiac surgery with cardiopulmonary bypass (CPB) were enrolled. Plasma PCT, aspartate aminotransferase/alanine aminotransferase (AST/ALT), creatinine, lactate, and C-reactive protein (CRP) were measured on admission to ICU and during the postoperative period...
2014: Journal of Intensive Care
https://www.readbyqxmd.com/read/25840070/utility-of-admission-serum-lactate-in-pediatric-trauma
#17
Rajesh Ramanathan, Dan W Parrish, Joseph E Hartwich, Jeffrey H Haynes
BACKGROUND/PURPOSE: Serum lactate measurement has a predictive value in adult trauma. To date, there has been no prospective analysis of the predictive value of admission serum lactate in pediatric trauma. METHODS: Admission serum lactate was prospectively measured over a two year period on all children under age 15 years who met trauma alert criteria at an urban Level 1 trauma center. Elevated serum lactate (>2.0 mmol/L) was correlated with Injury Severity Scores (ISS), injury types, and hospital outcomes...
April 2015: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/25513093/high-levels-of-procalcitonin-in-the-early-phase-after-pediatric-liver-transplantation-indicate-poor-postoperative-outcome
#18
R Zant, M Melter, H J Schlitt, M Loss, M Ameres, B Knoppke, Kunkel J
BACKGROUND/AIMS: To date, no data is available about procalcitonin (PCT) levels and its relevance to morbidity and graft function in the early phase after pediatric liver transplantation (pLTx). The aim of this study was to analyse the prognostic relevance of early postoperative PCT elevations in pediatric liver recipients. METHODOLOGY: Thirty pediatric patients who underwent 32 liver transplantations were included into this observational single-center study. RESULTS: Patients with high PCT levels on postoperative day (POD) 2 had higher International Normalized Ratio values on POD 5 (p<0...
July 2014: Hepato-gastroenterology
https://www.readbyqxmd.com/read/25436308/high-levels-of-procalcitonin-in-the-early-phase-after-pediatric-liver-transplantation-indicate-poor-postoperative-outcome
#19
R Zant, M Melter, H J Schlitt, M Loss, M Ameres, B Knoppke, Kunkel J
BACKGROUND/AIMS: To date, no data is available about procalcitonin (PCT) levels and its relevance to morbidity and graft function in the early phase after pediatric liver transplantation (pLTx). The aim of this study was to analyse the prognostic relevance of early postoperative PCT elevations in pediatric liver recipients. METHODOLOGY: Thirty pediatric patients who underwent 32 liver transplantations were included into this observational single-center study. RESULTS: Patients with high PCT levels on postoperative day (POD) 2 had higher International Normalized Ratio values on POD 5 (p<0...
July 2014: Hepato-gastroenterology
https://www.readbyqxmd.com/read/25419904/lymphadenopathy-in-a-series-of-egyptian-pediatric-patients-and-the-role-of-pathology-in-the-diagnostic-workup
#20
Noha M Gwili, Mona A Hadi, Amina N Eldin, Hoda M Hassab, Yasser S Eldin, Shady H Fadel, Nagwa A Mashali
Assessment of lymphadenopathy in children represents a diagnostic challenge because of the extensive differential diagnoses, including reactive and malignant conditions. Knowledge of the etiologic pattern of lymphadenopathy in a given geographical region is essential for making a confident diagnosis or for suspecting a disease. Hence, the present study was carried out to identify different etiologies of lymphadenopathy in children in our region and to assess parameters commonly associated with malignancy, with an emphasis on the role of pathology...
September 2014: Pediatric and Developmental Pathology
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