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https://www.readbyqxmd.com/read/28104073/af-ablation-guided-by-spatiotemporal-electrogram-dispersion%C3%A2-without-pulmonary-vein-isolation-a-wholly-patient-tailored-approach
#1
Julien Seitz, Clément Bars, Guillaume Théodore, Sylvain Beurtheret, Nicolas Lellouche, Michel Bremondy, Ange Ferracci, Jacques Faure, Guillaume Penaranda, Masatoshi Yamazaki, Uma Mahesh R Avula, Laurence Curel, Sabrina Siame, Omer Berenfeld, André Pisapia, Jérôme Kalifa
BACKGROUND: The use of intracardiac electrograms to guide atrial fibrillation (AF) ablation has yielded conflicting results. OBJECTIVES: The authors evaluated the usefulness of spatiotemporal dispersion, a visually recognizable electric footprint of AF drivers, for the ablation of all forms of AF. METHODS: The authors prospectively enrolled 105 patients admitted for AF ablation. AF was sequentially mapped in both atria with a 20-pole PentaRay catheter...
January 24, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28100216/antispasmodic-bronchodilator-vasorelaxant-and-cardiosuppressant-effects-of-buxus-papillosa
#2
Arif-Ullah Khan, Shamsher Ali, Anwarul-Hassan Gilani, Manzoor Ahmed, Muhammad Iqbal Choudhary
BACKGROUND: The present research was carried out to investigate pharmacological properties of Buxus papillosa C.K. Schneid. (Buxaceae). METHODS: Buxus papillosa extracts of leaves (BpL), stem (BpS), roots (BpR) and BpL fractions: hexane (BpL-H), aqueous (BpL-A) also plant constituent, cyclomicrobuxine effect were studied in jejunum, atria, aorta and tracheal preparations from rabbit and guine-peg. RESULTS: Ca(++) antagonistic effect of BpS, BpR, BpL-H, BpL-A and cyclomicrobuxine were conclusively suggested, when spontaneous contractions of rabbit jejunal preparation was relaxed along with subsequent relaxation of potassium chloride (80 mM) induced contractions...
January 18, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28091410/molecular-mechanisms-of-increased-heart-rate-in-shenxianshengmai-treated-bradycardia-rabbits
#3
Zhou-Ying Liu, Jian Huang, Na-Na Liu, Min Zheng, Tao Zhao, Bu-Chang Zhao, Yi-Min Wang, Jie-Lin Pu
BACKGROUND: The molecular mechanisms of Shenxianshengmai (SXSM), a traditional Chinese medicine, on bradycardia have been incompletely understood. The study tried to investigate the gene expression profile and proteomics of bradycardia rabbits' hearts after SXSM treatment. METHODS: Twenty-four adult rabbits were randomly assigned in four groups: sham, model, model plus SXSM treatment, and sham plus SXSM treatment groups. Heart rate was recorded in all rabbits. Then, total RNA of atria and proteins of ventricle were isolated and quantified, respectively...
2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28059795/evidence-of-a-cardiovascular-function-for-microtubule-associated-protein-tau
#4
Ashenafi H Betrie, Scott Ayton, Ashley I Bush, James A Angus, Peng Lei, Christine E Wright
Aggregation of tau protein into intracellular deposits is a pathognomonic feature of tauopathies such as Alzheimer's disease (AD) and lowering tau is a prominent therapeutic strategy under development. However, the physiological function of tau protein is not well known, particularly in the periphery. Lowering tau protein risks disrupting its physiological role leading to unwanted effects. In this study, the presence of tau protein in cardiac tissue is confirmed and the functional role in the cardiovascular system and the consequences of its loss were explored...
December 3, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28011828/changes-in-p-wave-morphology-after-pulmonary-vein-isolation-insights-from-computer-simulations
#5
Mirabeau Saha, Giulio Conte, Maria Luce Caputo, François Regoli, Rolf Krause, Angelo Auricchio, Vincent Jacquemet
AIMS: Apparently conflicting clinical measurements of P-wave duration (PWD) pre- vs. post-ablation have been reported. To assist the interpretation of these clinical data, we used a computer model of the atria and torso to simulate P waves before and after pulmonary vein (PV) isolation. METHODS AND RESULTS: Twenty ablation patterns were designed (segmental or ipsilateral ablation; five distances to PV sleeves; addition of a roof line or not). Possible PV reconnections were introduced as gaps in the ablation lines...
December 2016: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/27875722/progenitor-cells-from-atria-ventricle-and-peripheral-blood-of-the-same-patients-exhibit-functional-differences-associated-with-cardiac-repair
#6
Parul Dixit, Hayden Donnelly, Midori Edamatsu, Ivor Galvin, Richard Bunton, Rajesh Katare
AIM: Deciding the best cell type for cardiac regeneration remains a big challenge. No studies have directly compared the functional efficacy of cardiac progenitor cells (CPCs) with extra-cardiac stem cells isolated from the same patient. METHODS AND RESULTS: We compared the functional characteristics of endothelial progenitor cells (EPCs), right atrial (RAA) CPCs and left ventricular (LV) CPCs isolated from the same patients (n=14). Within the same heart, RAA and LV CPCs exhibited marked differences in surface marker expression, with RAA CPCs exhibiting better expansion potential and migration properties...
February 1, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/27863381/probucol-prevents-atrial-ion-channel-remodeling-in-an-alloxan-induced-diabetes-rabbit-model
#7
Huaying Fu, Guangping Li, Changle Liu, Jian Li, Lijun Cheng, Wansong Yang, Gary Tse, Jichao Zhao, Tong Liu
Diabetes mellitus (DM) increases the risk of developing atrial fibrillation (AF), but the molecular mechanisms of diabetes-induced atrial remodeling processes have not been fully characterized. The aim of this study was to examine the mechanisms underlying atrial ion channel remodeling in alloxan-induced diabetes model in rabbits. A total of 40 Japanese rabbits were randomly assigned to a control group (C), alloxan-induced diabetic group (DM), probucol-treated control group (Control-P), and probucol-treated diabetic group (DM-P)...
November 14, 2016: Oncotarget
https://www.readbyqxmd.com/read/27773652/refractoriness-in-human-atria-time-and-voltage-dependence-of-sodium-channel-availability
#8
Lasse Skibsbye, Thomas Jespersen, Torsten Christ, Mary M Maleckar, Jonas van den Brink, Pasi Tavi, Jussi T Koivumäki
BACKGROUND: Refractoriness of cardiac cells limits maximum frequency of electrical activity and protects the heart from tonic contractions. Short refractory periods support major arrhythmogenic substrates and augmentation of refractoriness is therefore seen as a main mechanism of antiarrhythmic drugs. Cardiomyocyte excitability depends on availability of sodium channels, which involves both time- and voltage-dependent recovery from inactivation. This study therefore aims to characterise how sodium channel inactivation affects refractoriness in human atria...
December 2016: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/27706179/noninvasive-imaging-of-human-atrial-activation-during-atrial-flutter-and-normal-rhythm-from-body-surface-potential-maps
#9
Zhaoye Zhou, Qi Jin, Long Yu, Liqun Wu, Bin He
BACKGROUND: Knowledge of atrial electrophysiological properties is crucial for clinical intervention of atrial arrhythmias and the investigation of the underlying mechanism. This study aims to evaluate the feasibility of a novel noninvasive cardiac electrical imaging technique in imaging bi-atrial activation sequences from body surface potential maps (BSPMs). METHODS: The study includes 7 subjects, with 3 atrial flutter patients, and 4 healthy subjects with normal atrial activations...
2016: PloS One
https://www.readbyqxmd.com/read/27660028/angiotensin-1-5-an-active-mediator-of-renin-angiotensin-system-stimulates-anp-secretion-via-mas-receptor
#10
Lamei Yu, Kuichang Yuan, Hoang Thi Ai Phuong, Byung Mun Park, Suhn Hee Kim
Angiotensin-(1-5) [Ang-(1-5)], which is a metabolite of Angiotensin-(1-7) [Ang-(1-7)] catalyzed by angiotensin-converting enzyme (ACE), is a pentapeptide of the renin-angiotensin system (RAS). It has been reported that Ang-(1-7) and Ang-(1-9) stimulate the secretion of atrial natriuretic peptide (ANP) via Mas receptor (Mas R) and Ang II type 2 receptor (AT2R), respectively. However, it still remains unknown whether Ang-(1-5) has a similar function to Ang-(1-7). We investigated the effect of Ang-(1-5) on ANP secretion and to define its signaling pathway using isolated perfused beating rat atria...
December 2016: Peptides
https://www.readbyqxmd.com/read/27609676/ganglion-plexus-ablation-in-advanced%C3%A2-atrial-fibrillation-the-afact-study
#11
Antoine H G Driessen, Wouter R Berger, Sébastien P J Krul, Nicoline W E van den Berg, Jolien Neefs, Femke R Piersma, Dean R P P Chan Pin Yin, Jonas S S G de Jong, WimJan P van Boven, Joris R de Groot
BACKGROUND: Patients with long duration of atrial fibrillation (AF), enlarged atria, or failed catheter ablation have advanced AF and may require more extensive treatment than pulmonary vein isolation. OBJECTIVES: The aim of this study was to investigate the efficacy and safety of additional ganglion plexus (GP) ablation in patients undergoing thoracoscopic AF surgery. METHODS: Patients with paroxysmal AF underwent pulmonary vein isolation...
September 13, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27525575/cardiac-n-methyl-d-aspartate-receptors-as-a-pharmacological-target
#12
Asya Makhro, Qinghai Tian, Lars Kaestner, Dmitry Kosenkov, Giuseppe Faggian, Max Gassmann, Colin Schwarzwald, Anna Bogdanova
This study focuses on characterization of the cardiac N-methyl D-aspartate receptors (NMDARs) as a target for endogenous and synthetic agonists and antagonists. Using isolated perfused rat hearts, we have shown that intracoronary administration of the NMDAR agonists and antagonists has a pronounced effect on autonomous heart function. Perfusion of rat hearts with autologous blood supplemented with NMDAR agonists was associated with induction of tachycardia, sinus arrhythmia and ischemia occurring within physiological plasma concentration range for glutamate and glycine...
August 10, 2016: Journal of Cardiovascular Pharmacology
https://www.readbyqxmd.com/read/27496871/c-type-natriuretic-peptide-and-natriuretic-peptide-receptor-b-signalling-inhibits-cardiac-sympathetic-neurotransmission-and-autonomic-function
#13
Jens Buttgereit, Julia Shanks, Dan Li, Guoliang Hao, Arvinder Athwal, Thomas H Langenickel, Hannah Wright, Andrey C da Costa Goncalves, Jan Monti, Ralph Plehm, Elena Popova, Fatimunnisa Qadri, Irina Lapidus, Brent Ryan, Cemil Özcelik, David J Paterson, Michael Bader, Neil Herring
AIMS: B-type natriuretic peptide (BNP)-natriuretic peptide receptor A (NPR-A) receptor signalling inhibits cardiac sympathetic neurotransmission, although C-type natriuretic peptide (CNP) is the predominant neuropeptide of the nervous system with expression in the heart and vasculature. We hypothesized that CNP acts similarly to BNP, and that transgenic rats (TGRs) with neuron-specific overexpression of a dominant negative NPR-B receptor would develop heightened sympathetic drive. METHODS AND RESULTS: Mean arterial pressure and heart rate (HR) were significantly (P < 0...
December 2016: Cardiovascular Research
https://www.readbyqxmd.com/read/27465664/design-synthesis-and-negative-inotropic-evaluation-of-4-phenyl-1h-1-2-4-triazol-5-4h-one-derivatives-containing-triazole-or-piperazine-moieties
#14
Zhi-Yu Wei, Bai-Ri Cui, Xun Cui, Yan-Ling Wu, Yang Fu, Li-Ping Liu, Hu-Ri Piao
In this study, four novel series of 4-phenyl-1H-1,2,4-triazol-5(4H)-one derivatives containing triazole or piperazine moieties were designed, synthesized, and evaluated for negative inotropic activity by measuring the left atrium stroke volume in isolated rabbit heart preparations. Almost all of the compounds showed an ability to moderate the cardiac workload by decreasing the heart rate and contractility. Among them, 7h was found to be the most potent with a change in stroke volume of -48.22 ± 0.36% at a concentration of 3 × 10(-5)  mol/L (metoprolol: -9...
January 2017: Chemical Biology & Drug Design
https://www.readbyqxmd.com/read/27417385/synthesis-and-in-vitro-pharmacological-evaluation-of-5-alkoxymethyl-2-3-alkylamino-2-hydroxypropoxy-phenylethanones-related-to-acebutolol-and-celiprolol
#15
Katarína Bruchatá, Andrej Némethy, Ružena Čižmáriková, Eva Račanská, Ladislav Habala
The structure-activity relationships of 13 analogs of aryloxyaminopropanol type derived from 2-hydroxyphenylethanone as potential β-blockers are described. The synthesized compounds possess an isopropyl or a tert-butyl group in the hydrophilic part of the molecule and an alkoxymethyl substitution in the lipophilic moiety. The target compounds were prepared by an established four-step method and their structures were confirmed by interpretation of their UV, IR, (1) H NMR and (13) C NMR spectra, and by elemental analysis...
September 2016: Archiv der Pharmazie
https://www.readbyqxmd.com/read/27372606/early-left-atrial-tissue-features-in-patients-with-chronic-mitral-regurgitation-and-sinus-rhythm-alterations-of-not-remodeled-left-atria
#16
Chiara Foglieni, Raffaella Rusconi, Maria Elena Mantione, Gabriele Fragasso, Ottavio Alfieri, Francesco Maisano
OBJECTIVE: Left atrial (LA) enlargement, a compensatory mechanism in chronic mitral regurgitation (MR) increasing the risk of atrial fibrillation (AF) and predictive of cardiac events, involves structural alterations. We characterized LA features in patients in sinus rhythm with severe degree of MR, similar degrees of left ventricular remodeling but divergent LA size. METHODS: Among a consecutive series of 163 patients in stable sinus rhythm undergoing isolated mitral valve surgery for severe non-rheumatic MR, two groups were arbitrarily selected according to their LA size (antero-posterior): NRLA group (non-remodeled LA) included 8 patients with LA≤40mm, RLA group (remodeled LA) included 8 patients with LA>55mm...
September 15, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27353237/acute-effects-of-unilateral-temporary-stellate-ganglion-block-on-human-atrial-electrophysiological-properties-and-atrial-fibrillation-inducibility
#17
Dionyssios Leftheriotis, Panayota Flevari, Charalampos Kossyvakis, Dimitrios Katsaras, Chrysanthi Batistaki, Chrysa Arvaniti, Georgios Giannopoulos, Spyridon Deftereos, Georgia Kostopanagiotou, Ioannis Lekakis
BACKGROUND: In experimental models, stellate ganglion block (SGB) reduces the induction of atrial fibrillation (AF), while data in humans are limited. OBJECTIVE: The aim of this study was to assess the effect of unilateral SGB on atrial electrophysiological properties and AF induction in patients with paroxysmal AF. METHODS: Thirty-six patients with paroxysmal AF were randomized in a 2:1 order to temporary, transcutaneous, pharmaceutical SGB with lidocaine or placebo before pulmonary vein isolation...
June 21, 2016: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/27345093/long-term-success-for-the-convergent-atrial-fibrillation-procedure-4-year-outcomes
#18
Borut Geršak, Matevž Jan
BACKGROUND: The objective of this single-center study was to report long-term efficacy outcomes of the convergent procedure for the treatment of atrial fibrillation. METHODS: Outcomes for the convergent procedure were determined by clinical presentation and interrogating implanted loop recorders. Rhythm status and required interventions for atrial fibrillation recurrence (antiarrhythmic drugs, cardioversions, and repeat ablations) were quantified 1 to 4 years after the procedure...
June 24, 2016: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/27308259/the-instance-when-a-general-surgeon-lost-heart-isolated-blunt-traumatic-rupture-of-both-atria-and-pericardium
#19
Mahir Gachabayov, Dmitriy Neronov
No abstract text is available yet for this article.
April 2016: International Journal of Critical Illness and Injury Science
https://www.readbyqxmd.com/read/27302368/predictors-of-late-onset-atrial-fibrillation-following-isolated-mitral-valve-repairs-in-patients-with-preserved-ejection-fraction
#20
J Trent Magruder, Sarah Collica, Stephen Belmustakov, Todd C Crawford, Joshua C Grimm, Duke E Cameron, William A Baumgartner, Kaushik Mandal
BACKGROUND: We sought to determine the incidence of and risk factors for late-onset atrial fibrillation (LOAF) in patients with preserved ejection fractions undergoing mitral valve repair METHODS: We included patients undergoing isolated mitral valve repair (MVR) for degenerative disease between 1997-2014 at our institution with EF ≥60%. Patients who had AF preoperatively were excluded from the final analysis. Our primary outcome, LOAF, was defined as AF occurring after discharge following MVR (≥9 days)...
August 2016: Journal of Cardiac Surgery
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