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https://www.readbyqxmd.com/read/27899287/pre-treatment-with-vinpocetine-protects-against-retinal-ischemia
#1
Lisa Nivison-Smith, Pauline Khoo, Monica L Acosta, Michael Kalloniatis
Vinpocetine has been shown to have beneficial effects for tissues of the central nervous system subjected to ischemia and other related metabolic insults. We recently showed vinpocetine promotes glucose availability, prevents unregulated cation channel permeability and regulates glial reactivity when present during retinal ischemia. Less is known however about the ability of vinpocetine to protect against future ischemic insults. This study explores the effect of vinpocetine when used as a pre-treatment in an ex vivo model for retinal ischemia using cation channel permeability of agmatine (AGB) combined with immunohistochemistry as a measure for cell functionality...
November 26, 2016: Experimental Eye Research
https://www.readbyqxmd.com/read/27873165/analysing-the-effect-of-i1-imidazoline-receptor-ligands-on-dss-induced-acute-colitis-in-mice
#2
Ágnes Fehér, Viktória E Tóth, Mahmoud Al-Khrasani, Mihály Balogh, Bernadette Lázár, Zsuzsanna Helyes, Klára Gyires, Zoltán S Zádori
Imidazoline receptors (IRs) have been recognized as promising targets in the treatment of numerous diseases; and moxonidine and rilmenidine, agonists of I1-IRs, are widely used as antihypertensive agents. Some evidence suggests that IR ligands may induce anti-inflammatory effects acting on I1-IRs or other molecular targets, which could be beneficial in patients with inflammatory bowel disease (IBD). On the other hand, several IR ligands may stimulate also alpha2-adrenoceptors, which were earlier shown to inhibit, but in more recent studies to rather aggravate colitis...
November 21, 2016: Inflammopharmacology
https://www.readbyqxmd.com/read/27846445/mammalian-agmatinases-constitute-unusual-members-in-the-family-of-mn-2-dependent-ureahydrolases
#3
Nicol Romero, José Benítez, David Garcia, Arlette González, Leonardo Bennun, María A García-Robles, Vasthi López, Liam A Wilson, Gerhard Schenk, Nelson Carvajal, Elena Uribe
Agmatine (1-amino-4-guanidinobutane) plays an important role in a range of metabolic functions, in particular in the brain. Agmatinases (AGMs) are enzymes capable of converting agmatine to the polyamine putrescine and urea. AGMs belong to the family of Mn(2+)-dependent ureahydrolases. However, no AGM from a mammalian source has yet been extracted in catalytically active form. While in human AGM the six amino acid ligands that coordinate the two Mn(2+) ions in the active site are conserved, four mutations are observed in the murine enzyme...
November 9, 2016: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/27836390/agmatine-a-potential-novel-therapeutic-strategy-for-depression
#4
Andiara E Freitas, Vivian B Neis, Ana Lúcia S Rodrigues
Major depressive disorder is the most common psychiatric disorder with lifetime prevalence of up to 20% worldwide. It is responsible for more years lost to disability than any other disorder. Despite the fact that current available antidepressant drugs are safe and effective, they are far from ideal. In addition to the need to administer the drugs for weeks or months to obtain clinical benefit, side effects are still a serious problem. Agmatine is an endogenous polyamine synthesized by the enzyme arginine decarboxylase...
November 8, 2016: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/27810390/agmatine-ameliorates-type-2-diabetes-induced-alzheimer-s-disease-like-alterations-in-high-fat-diet-fed-mice-via-reactivation-of-blunted-insulin-signalling
#5
Somang Kang, Chul-Hoon Kim, Hosung Jung, Eosu Kim, Ho-Taek Song, Jong Eun Lee
The risk of Alzheimer's disease (AD) is higher in patients with type 2 diabetes mellitus (T2DM). Previous studies in high-fat diet-induced AD animal models have shown that brain insulin resistance in these animals leads to the accumulation of amyloid beta (Aβ) and the reduction in GSK-3β phosphorylation, which promotes tau phosphorylation to cause AD. No therapeutic treatments that target AD in T2DM patients have yet been discovered. Agmatine, a primary amine derived from l-arginine, has exhibited anti-diabetic effects in diabetic animals...
October 31, 2016: Neuropharmacology
https://www.readbyqxmd.com/read/27801550/herring-and-chicken-pork-meals-lead-to-differences-in-plasma-levels-of-tca-intermediates-and-arginine-metabolites-in-overweight-and-obese-men-and-women
#6
Andrew Vincent, Otto I Savolainen, Partho Sen, Nils-Gunnar Carlsson, Annette Almgren, Helen Lindqvist, Mads Vendelbo Lind, Ingrid Undeland, Ann-Sofie Sandberg, Alastair B Ross
SCOPE: What effect does replacing chicken or pork with herring as the main dietary source of protein have on the human plasma metabolome. METHOD AND RESULTS: A randomized crossover trial with fifteen healthy obese men and women (age 24-70 years). Subjects were randomly assigned to four weeks of herring diet or a reference diet of chicken and lean pork, five meals per week, followed by a washout and the other intervention arm. Fasting blood serum metabolites were analysed at 0, 2 and 4 weeks for eleven subjects with available samples, using GC-MS based metabolomics...
November 1, 2016: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/27774136/combined-interactions-with-i1-i2-imidazoline-binding-sites-and-%C3%AE-2-adrenoceptors-to-manage-opioid-addiction
#7
Maria Elena Giusepponi, Carlo Cifani, Maria Vittoria Micioni Di Bonaventura, Laura Mattioli, Alan Hudson, Eleonora Diamanti, Fabio Del Bello, Mario Giannella, Valerio Mammoli, Corinne Dalila Paoletti, Alessandro Piergentili, Maria Pigini, Wilma Quaglia
Tolerance and dependence associated with chronic opioid exposure result from molecular, cellular, and neural network adaptations. Such adaptations concern opioid and nonopioid systems, including α2-adrenoceptors (α2-ARs) and I1- and I2-imidazoline binding sites (IBS). Agmatine, one of the hypothesized endogenous ligands of IBS, targeting several systems including α2-ARs and IBS, proved to be able to regulate opioid-induced analgesia and to attenuate the development of tolerance and dependence. Interested in the complex pharmacological profile of agmatine and considering the nature of its targets, we evaluated two series of imidazolines, rationally designed to simultaneously interact with I1-/I2-IBS or I1-/I2-IBS/α2-ARs...
October 13, 2016: ACS Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/27743829/acute-agmatine-administration-similar-to-ketamine-reverses-depressive-like-behavior-induced-by-chronic-unpredictable-stress-in-mice
#8
Vivian B Neis, Luis E B Bettio, Morgana Moretti, Priscila B Rosa, Camille M Ribeiro, Andiara E Freitas, Filipe M Gonçalves, Rodrigo B Leal, Ana Lúcia S Rodrigues
Agmatine is an endogenous neuromodulator that has been shown to have antidepressant-like properties. We have previously demonstrated that it can induce a rapid increase in BDNF levels after acute administration, suggesting that agmatine may be a fast-acting antidepressant. To investigate this hypothesis, the present study evaluated the effects of a single administration of agmatine in mice subjected to chronic unpredictable stress (CUS), a model of depression responsive only to chronic treatment with conventional antidepressants...
October 12, 2016: Pharmacology, Biochemistry, and Behavior
https://www.readbyqxmd.com/read/27729248/new-2-aminothiazoline-derivatives-lower-blood-pressure-of-spontaneously-hypertensive-rats-shr-via-i1-imidazoline-and-alpha-2-adrenergic-receptors-activation
#9
Renan B Ferreira, Mariana G de Oliveira, Edson Antunes, Wanda P Almeida, Badr M Ibrahim, Abdel A Abdel-Rahman
2-Aminothiazolines share an isosteric relationship with imidazolines and oxazolines with antihypertensive activity mainly mediated by the imidazoline I1-receptor. In the present work, we have prepared five aminothiazolines, following a previously described synthetic pathway. Aminothiazolines derived from dicyclopropylmethylamine (ATZ1) and cyclohexylamine (3) are unprecedented in the literature. Competitive radioligand assay was carried out with all synthetic compounds, and the I1 receptor affinity in comparison to rilmenidine in PC12 cells was determined...
October 8, 2016: European Journal of Pharmacology
https://www.readbyqxmd.com/read/27685463/agmatine-reduces-lipopolysaccharide-mediated-oxidant-response-via-activating-pi3k-akt-pathway-and-up-regulating-nrf2-and-ho-1-expression-in-macrophages
#10
Jianshen Chai, Li Luo, Fengyan Hou, Xia Fan, Jing Yu, Wei Ma, Wangqi Tang, Xue Yang, Junyu Zhu, Wenyuan Kang, Jun Yan, Huaping Liang
Macrophages are key responders of inflammation and are closely related with oxidative stress. Activated macrophages can enhance oxygen depletion, which causes an overproduction of reactive oxygen species (ROS) and leads to further excessive inflammatory response and tissue damage. Agmatine, an endogenous metabolite of L-arginine, has recently been shown to have neuroprotective effects based on its antioxidant properties. However, the antioxidant effects of agmatine in peripheral tissues and cells, especially macrophages, remain unclear...
2016: PloS One
https://www.readbyqxmd.com/read/27638633/agmatine-protects-rat-liver-from-nicotine-induced-hepatic-damage-via-antioxidative-antiapoptotic-and-antifibrotic-pathways
#11
Nagla A El-Sherbeeny, Manar A Nader, Ghalia M Attia, Hayam Ateyya
Tobacco smoking with its various forms is a global problem with proved hazardous effects to human health. The present work was planned to study the defending role of agmatine (AGM) on hepatic oxidative stress and damage induced by nicotine in rats. Thirty-two rats divided into four groups were employed: control group, nicotine-only group, AGM group, and AGM-nicotine group. Measurements of serum hepatic biochemical markers, lipid profile, and vascular cell adhesion molecule-1 were done. In addition, malondialdehyde (MDA), superoxide dismutase (SOD), glutathione (GSH) activity, and nitrate/nitrite (NOx) levels were estimated in the liver homogenates...
September 16, 2016: Naunyn-Schmiedeberg's Archives of Pharmacology
https://www.readbyqxmd.com/read/27604130/evaluation-of-the-protective-effect-of-agmatine-against-cisplatin-nephrotoxicity-with-99mtc-dmsa-renal-scintigraphy-and-cystatin-c
#12
Yavuz Sami Salihoglu, Tarik Elri, Kanat Gulle, Murat Can, Mustafa Aras, Hale Sayan Ozacmak, Mehmet Cabuk
BACKGROUND: The aim of the current study was to investigate whether agmatine (AGM) has a protective effect against cisplatin-induced nephrotoxicity. MATERIALS AND METHODS: Thirty-two rats were randomly divided into four groups: (1) Saline (control); (2) Cisplatin (CDDP; 7.5 mg/kg intraperitoneally); (3) Agmatine (AGM; 10 mg/kg intraperitoneally); (4) Cisplatin plus agmatine (CDDP + AGM). Agmatine was given before and two consecutive days after cisplatin injection...
September 8, 2016: Renal Failure
https://www.readbyqxmd.com/read/27593875/suppression-of-microrna-let-7a-expression-by-agmatine-regulates-neural-stem-cell-differentiation
#13
Juhyun Song, Yumi Oh, Jong Youl Kim, Kyoung Joo Cho, Jong Eun Lee
PURPOSE: Neural stem cells (NSCs) effectively reverse some severe central nervous system (CNS) disorders, due to their ability to differentiate into neurons. Agmatine, a biogenic amine, has cellular protective effects and contributes to cellular proliferation and differentiation in the CNS. Recent studies have elucidated the function of microRNA let-7a (let-7a) as a regulator of cell differentiation with roles in regulating genes associated with CNS neurogenesis. MATERIALS AND METHODS: This study aimed to investigate whether agmatine modulates the expression of crucial regulators of NSC differentiation including DCX, TLX, c-Myc, and ERK by controlling let-7a expression...
November 2016: Yonsei Medical Journal
https://www.readbyqxmd.com/read/27570519/technological-factors-affecting-biogenic-amine-content-in-foods-a-review
#14
REVIEW
Fausto Gardini, Yesim Özogul, Giovanna Suzzi, Giulia Tabanelli, Fatih Özogul
Biogenic amines (BAs) are molecules, which can be present in foods and, due to their toxicity, can cause adverse effects on the consumers. BAs are generally produced by microbial decarboxylation of amino acids in food products. The most significant BAs occurring in foods are histamine, tyramine, putrescine, cadaverine, tryptamine, 2-phenylethylamine, spermine, spermidine, and agmatine. The importance of preventing the excessive accumulation of BAs in foods is related to their impact on human health and food quality...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27565891/arginine-decarboxylase-a-novel-biological-target-of-mercury-compounds-identified-in-pc12-cells
#15
Sufang Wang, Qiyan Lv, Yu Yang, Liang-Hong Guo, Bin Wan, Xiaomin Ren, Hui Zhang
Mercury compounds are well-known toxic environmental pollutants and potently induce severe neurotoxicological effects in human and experimental animals. Previous studies showed that one of the mechanisms of mercury compounds neurotoxicity arose from the over-activation of the N-methyl d-aspartate (NMDA)-type glutamate receptor induced by increased glutamate release. In this work, we aimed to investigate the molecular mechanisms of Hg compounds neurotoxicities by identifying their biological targets in cells...
October 15, 2016: Biochemical Pharmacology
https://www.readbyqxmd.com/read/27565220/pharmacological-analysis-of-the-cardiac-sympatho-inhibitory-actions-of-moxonidine-and-agmatine-in-pithed-spontaneously-hypertensive-rats
#16
Luis E Cobos-Puc, Araceli Sánchez-López, David Centurión
This study shows that in spontaneously hypertensive rats (SHR) of 14-weeks-old, the sympathetically-induced, but not noradrenaline-induced tachycardic response are higher than age-matched Wistar normotensive rats. Furthermore, in SHR the sympathetically-induced tachycardic response was: (1) unaffected by moxonidine (3μg/kgmin); (2) partially inhibited by B-HT 933 (30μg/kgmin), both at the lowest doses; and (3) completely inhibited by the highest doses of B-HT 933 (100μg/kgmin), moxonidine (10μg/kgmin) or agmatine (1000 and 3000μg/kgmin) while the noradrenaline-induced tachycardic responses remained unaffected by the above compounds, except by 3000μg/kgmin agmatine...
August 24, 2016: European Journal of Pharmacology
https://www.readbyqxmd.com/read/27523096/effects-of-agmatine-on-chlorpromazine-toxicity-in-the-liver-of-wistar-rats-the-possible-role-of-oxidant-antioxidant-imbalance
#17
Dejanovic Bratislav, Lavrnja Irena, Ninkovic Milica, Stojanovic Ivana, Djuric Ana, Dilber Sanda, Stevanovic Ivana
Chlorpromazine (CPZ) is a member of a widely used class of antipsychotic agents. The metabolic pathways of CPZ toxicity were examined by monitoring oxidative/nitrosative stress markers. The aim of the study was to investigate the hypothesis that agmatine (AGM) prevents oxidative stress in the liver of Wistar rats 48 hours after administration of CPZ. All tested compounds were administered intraperitoneally (i.p.) in one single dose. The animals were divided into control (C, 0.9% saline solution), CPZ (CPZ, 38...
August 11, 2016: Experimental Animals
https://www.readbyqxmd.com/read/27454783/putrescine-biosynthesis-in-lactococcus-lactis-is-transcriptionally-activated-at-acidic-ph-and-counteracts-acidification-of-the-cytosol
#18
Beatriz Del Rio, Daniel Linares, Victor Ladero, Begoña Redruello, Maria Fernandez, Maria Cruz Martin, Miguel A Alvarez
Lactococcus lactis subsp. cremoris CECT 8666 is a lactic acid bacterium that synthesizes the biogenic amine putrescine from agmatine via the agmatine deiminase (AGDI) pathway. The AGDI genes cluster includes aguR. This encodes a transmembrane protein that functions as a one-component signal transduction system, the job of which is to sense the agmatine concentration of the medium and accordingly regulate the transcription of the catabolic operon aguBDAC. The latter encodes the proteins necessary for agmatine uptake and its conversion into putrescine...
November 7, 2016: International Journal of Food Microbiology
https://www.readbyqxmd.com/read/27453424/agmatine-ameliorates-lipopolysaccharide-induced-depressive-like-behaviour-in-mice-by-targeting-the-underlying-inflammatory-and-oxido-nitrosative-mediators
#19
Nitin B Gawali, Vipin D Bulani, Amrita A Chowdhury, Padmini S Deshpande, Dnyaneshwar M Nagmoti, Archana R Juvekar
Experimental and clinical evidence indicates that pro-inflammatory cytokines, oxidative stress and brain-derived neurotrophic factor (BDNF) signalling mechanisms play a role in the pathophysiology of depression. Agmatine is a neurotransmitter and/or neuromodulator that has emerged as a potential agent to manage diverse central nervous system disorders. Agmatine has been shown to exert antidepressant-like effect. The present study investigated ability of agmatine to abolish the depressive-like behaviour induced by the administration of the lipopolysaccharide (LPS) in mice...
October 2016: Pharmacology, Biochemistry, and Behavior
https://www.readbyqxmd.com/read/27404284/involvement-of-the-agmatinergic-system-in-the-depressive-like-phenotype-of-the-crtc1-knockout-mouse-model-of-depression
#20
E M Meylan, L Breuillaud, T Seredenina, P J Magistretti, O Halfon, R Luthi-Carter, J-R Cardinaux
Recent studies implicate the arginine-decarboxylation product agmatine in mood regulation. Agmatine has antidepressant properties in rodent models of depression, and agmatinase (Agmat), the agmatine-degrading enzyme, is upregulated in the brains of mood disorder patients. We have previously shown that mice lacking CREB-regulated transcription coactivator 1 (CRTC1) associate behavioral and molecular depressive-like endophenotypes, as well as blunted responses to classical antidepressants. Here, the molecular basis of the behavioral phenotype of Crtc1(-/-) mice was further examined using microarray gene expression profiling that revealed an upregulation of Agmat in the cortex of Crtc1(-/-) mice...
2016: Translational Psychiatry
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