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Needle phobia

Jordana A Waxman, Miranda G DiLorenzo, Rebecca R Pillai Riddell, David B Flora, Saul Greenberg, Hartley Garfield
The current study sets forth to provide both descriptive data for preschool vaccination pain responding and examine longitudinal relationships over early childhood. Growth mixture modeling (GMM) was first used to describe stable subgroups of preschoolers based on their pain response patterns over 2-minutes post-needle. Secondly, a parallel-process growth curve model was used to assess the stability of acute pain responding from 12-months of age to preschool age. Specifically, we examined whether preschool pain-related distress or regulation could be predicted from 12-month acute pain responding...
February 11, 2017: Journal of Pain: Official Journal of the American Pain Society
Christian Moro, Jessica Bass, Anna Mae Scott, Elisa F D Canetti
BACKGROUND: Nicotinic acid and nonivamide are often applied topically during capillary blood collection to induce vasodilation. These molecules may have an influence on immune effector cell activity in nearby tissues. This study investigates whether the induction of flushing by nicotinic acid and nonivamide causes an inflammatory response that influences the composition of immune cells present in a capillary blood sample. METHODS: Females aged between 18 and 30 years old provided capillary blood samples...
January 19, 2017: Journal of Clinical Laboratory Analysis
Le Luo, Chunhua Lai
No abstract text is available yet for this article.
December 15, 2016: American Family Physician
Nasser Mikhail
Technosphere insulin (TI), Afrezza, is a powder form of short-acting regular insulin taken by oral inhalation with meals. Action of TI peaks after approximately 40-60 min and lasts for 2-3 h. TI is slightly less effective than subcutaneous insulin aspart, with mean hemoglobin A1c (HbA1c) reduction of 0.21% and 0.4%, respectively. When compared with technosphere inhaled placebo, the decrease in HbA1c levels was 0.8% and 0.4% with TI and placebo, respectively. Compared with insulin aspart, TI is associated with lower risk of late post-prandial hypoglycemia and weight gain...
December 15, 2016: World Journal of Diabetes
Norazirah Md Nor, Rasimah Ismail, Adawiyah Jamil, Shamsul Azhar Shah, Farah Hani Imran
BACKGROUND AND OBJECTIVE: Keloid is conventionally treated with intra-lesional (IL) triamcinolone, which is highly operator dependent and has its own adverse effects. Topical steroid and silicone dressings are a patient friendly and non-invasive treatment alternative. We therefore sought to determine the efficacy and safety of topical clobetasol propionate (Dermovate(®)) 0.05% cream under occlusion with Mepiform(®) silicone dressing compared to IL triamcinolone in the treatment of keloid...
March 2017: Clinical Drug Investigation
Xinxin Li, Bryan Ruddy, Andrew Taberner
Hypodermic injections have been the standard for transcutaneous drug delivery for many years. However, needle phobia, pain, and risks of needle-stick injuries have manifested in poor patient compliance. Needle-free jet injections (NFJI) have been developed to address these drawbacks but the reliability of dose and depth of delivery have been limited by a lack of control over jet parameters, and by variability in the skin's mechanical properties among individuals. Moreover, the device size and cost have been restrained by the high pressure (>20MPa) required to penetrate the skin...
December 10, 2016: Journal of Controlled Release: Official Journal of the Controlled Release Society
Tilman R Rohrer, Reiko Horikawa, Anne-Marie Kappelgaard
Adherence to daily growth hormone (GH) injections optimizes treatment benefit; however, adherence rates are sometimes poor. Reasons for poor adherence and persistence are multifaceted. GH injection devices are undergoing continual improvement to enhance adherence. Areas covered: This review evaluates published data on the evolution of GH injection devices to meet patients' needs and preferences, patients' perception of new devices and the projected impact of device developments on adherence. Published studies were identified through literature database searches including EMBASE and PubMed (January 1985-November 2015)...
November 4, 2016: Expert Opinion on Drug Delivery
Byeongsang Oh, Thomas Eade, Andrew Kneebone, Nick Pavlakis, Stephen Clarke, Guy Eslick, Jo River, Michael Back
OBJECTIVE: To explore the factors associated with utilisation of an acupuncture service in a tertiary oncology setting in an Australian public hospital. METHOD: Cancer patients attending oncology clinics at a university teaching hospital were invited to participate in the evaluation of acupuncture services from June 2014 to May 2015. Patients had a prior diagnosis of cancer (albeit at different stages) and were planning to receive, or were already receiving, systemic and/or radiation cancer treatment...
September 22, 2016: Acupuncture in Medicine: Journal of the British Medical Acupuncture Society
T Charles Witzel, Alison J Rodger, Fiona M Burns, Tim Rhodes, Peter Weatherburn
INTRODUCTION: Innovative strategies, such as HIV self-testing (HIVST), could increase HIV testing rates and diagnosis. Evidence to inform the design of an HIVST intervention in the UK is scarce with very little European data on this topic. This study aims to understand values and preferences for HIVST interventions targeting MSM in the UK. We explore the acceptability of HIVST among MSM in the context of known barriers and facilitators to testing for HIV; assess preferences for, and the concerns about, HIVST...
2016: PloS One
Lynda S Cook
Venipuncture is generally associated with some degree of pain, discomfort, and/or apprehension. Yet most patients accept it with tolerance, even nonchalance. A few, not only pediatric patients, exhibit a higher degree of anxiety and face the procedure with tears, tension, and a variety of bargaining techniques (ie, stick on the count of 3; use only this vein). But for 1 group of people, venipuncture is associated with such fear that avoidance of the procedure is practiced. The end results are detrimental to the patient and may have an impact on society as well...
September 2016: Journal of Infusion Nursing: the Official Publication of the Infusion Nurses Society
Yeon Jin Jeong, Ho Jun Kim, Ho Kwon, Hyung-Sup Shim, Bommie Florence Seo, Sung-No Jung
This study aimed to validate the usefulness of lidocaine gel during intermaxillary fixation using arch bars in patients with mandible fracture by comparing 2 patient groups: one group using lidocaine gel in intermaxillary fixation and the other group undergoing traditional local infiltration.Subjects were patients with mandible fracture undergoing intermaxillary fixation using arch bars from March 2003 to February 2007. Twenty-three patients were anesthetized in the upper and lower gingiva by 2% local lidocaine solution injection; another 23 underwent topical anesthesia with 2% lidocaine hydrochloride gel applied to the upper and lower gingiva...
July 2016: Journal of Craniofacial Surgery
T Kavanagh, A Dube, A Albert, V Gunka
BACKGROUND: Between 10-22% of the general population experience needle phobia. Needle phobic parturients are at increased risk of adverse outcomes. We assessed the efficacy of topical Ametop™ (tetracaine 4%) gel in reducing the pain associated with local anesthetic skin infiltration before neuraxial block in non-laboring women. METHODS: This was a prospective, randomized, double-blind, placebo-controlled study. Ametop™ or placebo was applied to the skin of the lower back at least 20min before neuraxial block using a standardized technique with 1% lidocaine skin infiltration...
August 2016: International Journal of Obstetric Anesthesia
Jane L Tuckerman, Lexa Shrestha, Joanne E Collins, Helen S Marshall
Understanding motivators and barriers of health care worker (HCW) vaccination programs is important for determining strategies to improve uptake. The aim of this study was to explore key drivers and HCW decision making related to recommended vaccines and seasonal influenza vaccination programs. We used a qualitative approach with semi-structured one-to-one interviews with 22 HCWs working at a tertiary pediatric and obstetric hospital in South Australia. A thematic analysis and coding were used to examine data...
July 2, 2016: Human Vaccines & Immunotherapeutics
Rana Malek, Stephen N Davis
INTRODUCTION: Gestational diabetes mellitus (GDM) complicates 10% of all pregnancies and is defined as hyperglycemia first noted during pregnancy. Rates of GDM are rising and untreated GDM results in complications for both mother and fetus. GDM is often managed by diet and exercise but 30-40% of women will require pharmacological intervention. Insulin has traditionally been the treatment of choice but since 2007, glyburide, a second generation sulfonylurea has become the most prescribed medication for GDM...
June 2016: Expert Opinion on Drug Metabolism & Toxicology
Xueting Wang, Ning Wang, Ning Li, Yuanyuan Zhen, Ting Wang
To overcome drawbacks of current injection vaccines, such as causing needle phobia, needing health professionals for inoculation, and generating dangerous sharps wastes, researchers have designed novel vaccines that are combined with various microneedle arrays (MAs), in particular, with the multifunctional particle-constructed MAs (MPMAs). MPMAs prove able to enhance vaccine stability through incorporating vaccine ingredients in the carrier, and can be painlessly inoculated by minimally trained workers or by self-administration, leaving behind no metal needle pollution while eliciting robust systemic and mucosal immunity to antigens, thanks to delivering vaccines to cutaneous or mucosal compartments enriched in professional antigen-presenting cells (APCs)...
August 2, 2016: Human Vaccines & Immunotherapeutics
Susana Rebelo Pacheco, Clara Abadesso, Ana Monteiro, Anna Taddio
No abstract text is available yet for this article.
August 2016: Acta Paediatrica
Rima B Shah, Manhar Patel, David M Maahs, Viral N Shah
Many patients with advanced type 2 diabetes mellitus (T2DM) and all patients with T1DM require insulin to keep blood glucose levels in the target range. The most common route of insulin administration is subcutaneous insulin injections. There are many ways to deliver insulin subcutaneously such as vials and syringes, insulin pens, and insulin pumps. Though subcutaneous insulin delivery is the standard route of insulin administration, it is associated with injection pain, needle phobia, lipodystrophy, noncompliance and peripheral hyperinsulinemia...
January 2016: International Journal of Pharmaceutical Investigation
Clement A Meseda, Vajini Atukorale, Jordan Kuhn, Falko Schmeisser, Jerry P Weir
The robustness of immune responses to an antigen could be dictated by the route of vaccine inoculation. Traditional smallpox vaccines, essentially vaccinia virus strains, that were used in the eradication of smallpox were administered by percutaneous inoculation (skin scarification). The modified vaccinia virus Ankara is licensed as a smallpox vaccine in Europe and Canada and currently undergoing clinical development in the United States. MVA is also being investigated as a vector for the delivery of heterologous genes for prophylactic or therapeutic immunization...
2016: PloS One
Tjalf Ziemssen, Lauren Sylvester, Mark Rametta, Amy Perrin Ross
INTRODUCTION: Multiple sclerosis (MS) typically requires life-long management with disease-modifying therapies (DMTs). Many DMTs require regular self-injection, and can be associated with injection site reactions, pain, and needle/injection phobia-but these can be addressed by improvements in autoinjector design. The aim of this study was to investigate patient satisfaction and preference for BETACONNECT™ (Bayer Pharma AG), a novel interferon beta-1b autoinjector. METHODS: Patients in Germany performing self-injections using BETACONNECT took part in the study...
December 2015: Neurology and Therapy
Nicole Prinz, Christina Bächle, Marianne Becker, Gabriele Berger, Angela Galler, Holger Haberland, Michael Meusers, Joaquina Mirza, Paul L Plener, Simone von Sengbusch, Michaela Thienelt, Reinhard W Holl
BACKGROUND: The latest American Association of Clinical Endocrinologists/American College of Endocrinologists consensus statement published in 2014 does not recommend continuous subcutaneous insulin infusion (CSII) in patients with mental health problems. This study investigated the use and discontinuation of CSII in daily routine care of type 1 diabetes (T1D) patients with or without comorbid mental disorders. MATERIALS AND METHODS: Insulin-treated T1D patients (n = 48,700) between 5 and 30 years of age (median [interquartile range], 15...
January 2016: Diabetes Technology & Therapeutics
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