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Needle phobia

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https://www.readbyqxmd.com/read/28974451/combining-amino-amide-salts-in-mucoadhesive-films-enhances-needle-free-buccal-anesthesia-in-adults
#1
Renê Oliveira do Couto, Camila Cubayachi, Paulo Linares Calefi, Renata Fonseca Vianna Lopez, Vinícius Pedrazzi, Cristiane Masetto De Gaitani, Osvaldo de Freitas
Needle-phobia is usually a great concern in dentistry, and the replacement of painful injections by patient-friendly needle-free topical formulations would bring several advantages in dental practice worldwide. In this pursuit, the effects of combining prilocaine hydrochloride (PCL) and lidocaine hydrochloride (LCL) in different proportions in mucoadhesive films on their in vitro permeation and retention through porcine esophageal mucosa was studied. Complementarily, the permeation and retention of isolated LCL was investigated...
September 30, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28938877/glibenclamide-and-metformin-versus-standard-care-in-gestational-diabetes-graces-a-feasibility-open-label-randomised-trial
#2
Rebecca M Reynolds, Fiona C Denison, Ed Juszczak, Jennifer L Bell, Jessica Penneycard, Mark W J Strachan, Robert S Lindsay, Claire I Alexander, Corinne D B Love, Sonia Whyte, Fiona Mackenzie, Ben Stenson, Jane E Norman
BACKGROUND: Metformin is widely used to treat gestational diabetes (GDM), but many women remain hyperglycaemic and require additional therapy. We aimed to determine recruitment rate and participant throughput in a randomised trial of glibenclamide compared with standard therapy insulin (added to maximum tolerated metformin) for treatment of GDM. METHODS: We conducted an open label feasibility study in 5 UK antenatal clinics among pregnant women 16 to 36 weeks' gestation with metformin-treated GDM...
September 22, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/28879311/recent-advances-in-topical-anesthesia
#3
REVIEW
Hyo-Seol Lee
Topical anesthetics act on the peripheral nerves and reduce the sensation of pain at the site of application. In dentistry, they are used to control local pain caused by needling, placement of orthodontic bands, the vomiting reflex, oral mucositis, and rubber-dam clamp placement. Traditional topical anesthetics contain lidocaine or benzocaine as active ingredients and are used in the form of solutions, creams, gels, and sprays. Eutectic mixtures of local anesthesia cream, a mixture of various topical anesthetics, has been reported to be more potent than other anesthetics...
December 2016: J Dent Anesth Pain Med
https://www.readbyqxmd.com/read/28826627/neurostimulation-for-abdominal-pain-related-functional-gastrointestinal-disorders-in-adolescents-a-randomised-double-blind-sham-controlled-trial
#4
Katja Kovacic, Keri Hainsworth, Manu Sood, Gisela Chelimsky, Rachel Unteutsch, Melodee Nugent, Pippa Simpson, Adrian Miranda
BACKGROUND: Development of safe and effective therapies for paediatric abdominal pain-related functional gastrointestinal disorders is needed. A non-invasive, US Food and Drug Administration-cleared device (Neuro-Stim, Innovative Health Solutions, IN, USA) delivers percutaneous electrical nerve field stimulation (PENFS) in the external ear to modulate central pain pathways. In this study, we evaluated the efficacy of PENFS in adolescents with abdominal pain-related functional gastrointestinal disorders...
October 2017: Lancet. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28747647/delivery-of-intracavernosal-therapies-using-needle-free-injection-devices
#5
D O'Kane, L Gibson, J du Plessis, A Davidson, D Bolton, N Lawrentschuk
ED affects a significant proportion of males worldwide. With an ever-aging population the prevalence of ED is predicted to double in the next decade. Oral PDE-5 inhibitors are the first-line treatment for ED and have revolutionised its management. These agents are however ineffective in some men. Intracavernosal injection (ICI) of vasoactive agents is an effective second-line therapy for ED. Despite proven efficacy, needle phobia and anxiety with self-needling limit the use of intracavernosal (IC) therapies...
November 2017: International Journal of Impotence Research
https://www.readbyqxmd.com/read/28530151/microneedles-for-vaccine-delivery-challenges-and-future-perspectives
#6
Chong In Shin, Seong Dong Jeong, N Sanoj Rejinold, Yeu-Chun Kim
Vaccine delivery to the skin using conventional needles is associated with needle-stick injuries and needle-phobia, which are all major obstacles to vaccination. The development of microneedles has enabled to overcome these limitations and as a result viral, DNA and bacterial vaccines have been studied for the delivery into the skin. Research has shown the superiority of microneedle vaccination over conventional needles in terms of immunogenicity, vaccine stability and dose-sparing abilities in animals and humans...
June 2017: Therapeutic Delivery
https://www.readbyqxmd.com/read/28196739/preschool-needle-pain-responding-establishing-normal
#7
Jordana A Waxman, Miranda G DiLorenzo, Rebecca R Pillai Riddell, David B Flora, Saul Greenberg, Hartley Garfield
The current study sets forth to provide descriptive data for preschool vaccination pain responding as well as examine longitudinal relationships over early childhood. Growth mixture modeling was first used to describe stable subgroups of preschoolers on the basis of their pain response patterns over 2-minutes post-needle. Secondly, a parallel-process growth curve model was used to assess the stability of acute pain responding from 12 months of age to preschool age. Specifically, we examined whether preschool pain-related distress or regulation could be predicted from 12-month acute pain responding...
February 11, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28102549/enhancing-capillary-blood-collection-the-influence-of-nicotinic-acid-and-nonivamide
#8
Christian Moro, Jessica Bass, Anna Mae Scott, Elisa F D Canetti
BACKGROUND: Nicotinic acid and nonivamide are often applied topically during capillary blood collection to induce vasodilation. These molecules may have an influence on immune effector cell activity in nearby tissues. This study investigates whether the induction of flushing by nicotinic acid and nonivamide causes an inflammatory response that influences the composition of immune cells present in a capillary blood sample. METHODS: Females aged between 18 and 30 years old provided capillary blood samples...
January 19, 2017: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/28075095/needle-phobia-a-vasovagal-response-during-acupuncture
#9
Le Luo, Chunhua Lai
No abstract text is available yet for this article.
December 15, 2016: American Family Physician
https://www.readbyqxmd.com/read/28031777/place-of-technosphere-inhaled-insulin-in-treatment-of-diabetes
#10
REVIEW
Nasser Mikhail
Technosphere insulin (TI), Afrezza, is a powder form of short-acting regular insulin taken by oral inhalation with meals. Action of TI peaks after approximately 40-60 min and lasts for 2-3 h. TI is slightly less effective than subcutaneous insulin aspart, with mean hemoglobin A1c (HbA1c) reduction of 0.21% and 0.4%, respectively. When compared with technosphere inhaled placebo, the decrease in HbA1c levels was 0.8% and 0.4% with TI and placebo, respectively. Compared with insulin aspart, TI is associated with lower risk of late post-prandial hypoglycemia and weight gain...
December 15, 2016: World Journal of Diabetes
https://www.readbyqxmd.com/read/27888448/a-randomized-single-blind-trial-of-clobetasol-propionate-0-05-cream-under-silicone-dressing-occlusion-versus-intra-lesional-triamcinolone-for-treatment-of-keloid
#11
RANDOMIZED CONTROLLED TRIAL
Norazirah Md Nor, Rasimah Ismail, Adawiyah Jamil, Shamsul Azhar Shah, Farah Hani Imran
BACKGROUND AND OBJECTIVE: Keloid is conventionally treated with intra-lesional (IL) triamcinolone, which is highly operator dependent and has its own adverse effects. Topical steroid and silicone dressings are a patient friendly and non-invasive treatment alternative. We therefore sought to determine the efficacy and safety of topical clobetasol propionate (Dermovate(®)) 0.05% cream under occlusion with Mepiform(®) silicone dressing compared to IL triamcinolone in the treatment of keloid...
March 2017: Clinical Drug Investigation
https://www.readbyqxmd.com/read/27746273/characterization-of-needle-assisted-jet-injections
#12
Xinxin Li, Bryan Ruddy, Andrew Taberner
Hypodermic injections have been the standard for transcutaneous drug delivery for many years. However, needle phobia, pain, and risks of needle-stick injuries have manifested in poor patient compliance. Needle-free jet injections (NFJI) have been developed to address these drawbacks but the reliability of dose and depth of delivery have been limited by a lack of control over jet parameters, and by variability in the skin's mechanical properties among individuals. Moreover, the device size and cost have been restrained by the high pressure (>20MPa) required to penetrate the skin...
December 10, 2016: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/27718757/growth-hormone-delivery-devices-current-features-and-potential-for-enhanced-treatment-adherence
#13
Tilman R Rohrer, Reiko Horikawa, Anne-Marie Kappelgaard
Adherence to daily growth hormone (GH) injections optimizes treatment benefit; however, adherence rates are sometimes poor. Reasons for poor adherence and persistence are multifaceted. GH injection devices are undergoing continual improvement to enhance adherence. Areas covered: This review evaluates published data on the evolution of GH injection devices to meet patients' needs and preferences, patients' perception of new devices and the projected impact of device developments on adherence. Published studies were identified through literature database searches including EMBASE and PubMed (January 1985-November 2015)...
November 4, 2016: Expert Opinion on Drug Delivery
https://www.readbyqxmd.com/read/27658799/factors-affecting-whether-or-not-cancer-patients-consider-using-acupuncture
#14
Byeongsang Oh, Thomas Eade, Andrew Kneebone, Nick Pavlakis, Stephen Clarke, Guy Eslick, Jo River, Michael Back
OBJECTIVE: To explore the factors associated with utilisation of an acupuncture service in a tertiary oncology setting in an Australian public hospital. METHOD: Cancer patients attending oncology clinics at a university teaching hospital were invited to participate in the evaluation of acupuncture services from June 2014 to May 2015. Patients had a prior diagnosis of cancer (albeit at different stages) and were planning to receive, or were already receiving, systemic and/or radiation cancer treatment...
April 2017: Acupuncture in Medicine: Journal of the British Medical Acupuncture Society
https://www.readbyqxmd.com/read/27611777/hiv-self-testing-among-men-who-have-sex-with-men-msm-in-the-uk-a-qualitative-study-of-barriers-and-facilitators-intervention-preferences-and-perceived-impacts
#15
T Charles Witzel, Alison J Rodger, Fiona M Burns, Tim Rhodes, Peter Weatherburn
INTRODUCTION: Innovative strategies, such as HIV self-testing (HIVST), could increase HIV testing rates and diagnosis. Evidence to inform the design of an HIVST intervention in the UK is scarce with very little European data on this topic. This study aims to understand values and preferences for HIVST interventions targeting MSM in the UK. We explore the acceptability of HIVST among MSM in the context of known barriers and facilitators to testing for HIV; assess preferences for, and the concerns about, HIVST...
2016: PloS One
https://www.readbyqxmd.com/read/27598066/needle-phobia
#16
Lynda S Cook
Venipuncture is generally associated with some degree of pain, discomfort, and/or apprehension. Yet most patients accept it with tolerance, even nonchalance. A few, not only pediatric patients, exhibit a higher degree of anxiety and face the procedure with tears, tension, and a variety of bargaining techniques (ie, stick on the count of 3; use only this vein). But for 1 group of people, venipuncture is associated with such fear that avoidance of the procedure is practiced. The end results are detrimental to the patient and may have an impact on society as well...
September 2016: Journal of Infusion Nursing: the Official Publication of the Infusion Nurses Society
https://www.readbyqxmd.com/read/27391518/the-use-of-topical-lidocaine-gel-during-intermaxillary-fixation-procedure
#17
Yeon Jin Jeong, Ho Jun Kim, Ho Kwon, Hyung-Sup Shim, Bommie Florence Seo, Sung-No Jung
This study aimed to validate the usefulness of lidocaine gel during intermaxillary fixation using arch bars in patients with mandible fracture by comparing 2 patient groups: one group using lidocaine gel in intermaxillary fixation and the other group undergoing traditional local infiltration.Subjects were patients with mandible fracture undergoing intermaxillary fixation using arch bars from March 2003 to February 2007. Twenty-three patients were anesthetized in the upper and lower gingiva by 2% local lidocaine solution injection; another 23 underwent topical anesthesia with 2% lidocaine hydrochloride gel applied to the upper and lower gingiva...
July 2016: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/27317550/a-randomized-controlled-trial-comparing-ametop%C3%A2-with-placebo-for-reducing-pain-associated-with-local-anesthetic-skin-infiltration-before-neuraxial-anesthesia-in-parturients
#18
RANDOMIZED CONTROLLED TRIAL
T Kavanagh, A Dube, A Albert, V Gunka
BACKGROUND: Between 10-22% of the general population experience needle phobia. Needle phobic parturients are at increased risk of adverse outcomes. We assessed the efficacy of topical Ametop™ (tetracaine 4%) gel in reducing the pain associated with local anesthetic skin infiltration before neuraxial block in non-laboring women. METHODS: This was a prospective, randomized, double-blind, placebo-controlled study. Ametop™ or placebo was applied to the skin of the lower back at least 20min before neuraxial block using a standardized technique with 1% lidocaine skin infiltration...
August 2016: International Journal of Obstetric Anesthesia
https://www.readbyqxmd.com/read/27245460/understanding-motivators-and-barriers-of-hospital-based-obstetric-and-pediatric-health-care-worker-influenza-vaccination-programs-in-australia
#19
Jane L Tuckerman, Lexa Shrestha, Joanne E Collins, Helen S Marshall
Understanding motivators and barriers of health care worker (HCW) vaccination programs is important for determining strategies to improve uptake. The aim of this study was to explore key drivers and HCW decision making related to recommended vaccines and seasonal influenza vaccination programs. We used a qualitative approach with semi-structured one-to-one interviews with 22 HCWs working at a tertiary pediatric and obstetric hospital in South Australia. A thematic analysis and coding were used to examine data...
July 2, 2016: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/27163280/pharmacokinetics-efficacy-and-safety-of-glyburide-for-treatment-of-gestational-diabetes-mellitus
#20
REVIEW
Rana Malek, Stephen N Davis
INTRODUCTION: Gestational diabetes mellitus (GDM) complicates 10% of all pregnancies and is defined as hyperglycemia first noted during pregnancy. Rates of GDM are rising and untreated GDM results in complications for both mother and fetus. GDM is often managed by diet and exercise but 30-40% of women will require pharmacological intervention. Insulin has traditionally been the treatment of choice but since 2007, glyburide, a second generation sulfonylurea has become the most prescribed medication for GDM...
June 2016: Expert Opinion on Drug Metabolism & Toxicology
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