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Hosein Naseri, Håkan Johansson, Karin Brolin
Finite element human body models are nowdays commonly used to simulate pre- and in-crash occupant response in order to develop advanced safety systems. In this study a biofidelic model for adipose tissue is developed for this application. It is a nonlinear viscoelastic model based on the Reese et al. formulation. The model is formulated in a large strain framework and applied for finite element simulation of two types of experiments: rheological experiments and ramped-displacement experiments. The adipose tissue behavior in both experiments are represented well by this model...
October 16, 2017: Journal of Biomechanical Engineering
Mengjia Xu, Dimitrios P Papageorgiou, Sabia Z Abidi, Ming Dao, Hong Zhao, George Em Karniadakis
Sickle cell disease (SCD) is a hematological disorder leading to blood vessel occlusion accompanied by painful episodes and even death. Red blood cells (RBCs) of SCD patients have diverse shapes that reveal important biomechanical and bio-rheological characteristics, e.g. their density, fragility, adhesive properties, etc. Hence, having an objective and effective way of RBC shape quantification and classification will lead to better insights and eventual better prognosis of the disease. To this end, we have developed an automated, high-throughput, ex-vivo RBC shape classification framework that consists of three stages...
October 2017: PLoS Computational Biology
Xinpeng Zhang, Weixian Xi, Sijia Huang, Katelyn Long, Christopher N Bowman
We report a wavelength-selective polymerization process controlled by visible/UV light, whereby a base is generated for anion-mediated thiol-Michael polymerization reaction upon exposure at one wavelength (400-500 nm), while radicals are subsequently generated for a second stage radical polymerization at a second, independent wavelength (365 nm). Dual wavelength, light controlled sequential polymerization not only provides a relatively soft intermediate polymer that facilitates optimum processing and modification under visible light exposure but also enables a highly cross-linked, rigid final material after the UV-induced second stage radical polymerization...
August 8, 2017: Macromolecules
Khanh-Hoa Tran-Ba, Daniel J Lee, Jieling Zhu, Keewook Paeng, Laura J Kaufman
Fibrillar type I collagen-based hydrogels are commonly used in tissue engineering and as matrices for biophysical studies. Mechanical and structural properties of these gels are known to be governed by the conditions under which fibrillogenesis occurs, exhibiting variation as a function of protein concentration, temperature, pH, and ionic strength. Deeper understanding of how macroscopic structure affects viscoelastic properties of collagen gels over the course of fibrillogenesis provides fundamental insight into biopolymer gel properties and promises enhanced control over the properties of such gels...
October 17, 2017: Biophysical Journal
Siyang Xiao, Yongchao Zeng, Eric D Vavra, Peng He, Maura C Puerto, George J Hirasaki, Sibani Lisa Biswal
Foam flooding in porous media is of increasing interest due to its numerous applications such as enhanced oil recovery, aquifer remediation, and hydraulic fracturing. However, the mechanisms of oil-foam interactions have yet to be fully understood at the pore level. Here, we present three characteristic zones identified in experiments involving the displacement of crude oil from model porous media via surfactant-stabilized foam, and we describe a series of pore-level dynamics in these zones which were not observed in experiments involving paraffin oil...
October 18, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
Sarah Bertlein, Gabriella Brown, Khoon S Lim, Tomasz Jungst, Thomas Boeck, Torsten Blunk, Joerg Tessmar, Gary J Hooper, Tim B F Woodfield, Juergen Groll
Bioprinting can be defined as the art of combining materials and cells to fabricate designed, hierarchical 3D hybrid constructs. Suitable materials, so called bioinks, have to comply with challenging rheological processing demands and rapidly form a stable hydrogel postprinting in a cytocompatible manner. Gelatin is often adopted for this purpose, usually modified with (meth-)acryloyl functionalities for postfabrication curing by free radical photopolymerization, resulting in a hydrogel that is cross-linked via nondegradable polymer chains of uncontrolled length...
October 17, 2017: Advanced Materials
Hao Cai, Bartosz Gabryelczyk, Malathy S S Manimekalai, Gerhard Grüber, Stefan Salentinig, Ali Miserez
The beak of the Humboldt squid is a biocomposite material made solely of organic components - chitin and proteins - which exhibits 200-fold stiffness and hardness gradients from the soft base to the exceptionally hard tip (rostrum). The outstanding mechanical properties of the squid beak are achieved via controlled hydration and impregnation of the chitin-based scaffold by protein coacervates. Molecular-based understanding of these proteins is essential to mimic the natural beak material. Here, we present detailed studies of two histidine-rich beak proteins (HBP-1 and -2) that play central roles during beak bio-fabrication...
October 18, 2017: Soft Matter
Sang-Hun Yoo, Yoon Hyuk Chang
The purposes of this study were to produce polysaccharides from red pepper stems using different extraction methods and evaluate their chemical composition, in vitro biological capacities, and rheological properties. Two polysaccharides were extracted from red pepper stems using an autoclave and alkali treatments, and the extracts were named PAU and PAL, respectively. The contents of total phenolics and flavonoids were significantly higher in PAU than those in PAL. PAU exhibited greater scavenging activities on 2,2-diphenyl-1-picrylhydrazyl radicals, 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt radicals, superoxide radicals, and nitrite compared to PAL, suggesting that PAU served as better antioxidants...
September 2017: Preventive Nutrition and Food Science
Simin Belali, Ganapathi Emandi, Atillio A Cafolla, Barry O'Connell, Benjamin Haffner, Matthias E Möbius, Alireza Karimi, Mathias O Senge
3,5-Diformyl-4,4-difluoro-4-bora-3a,4a-diaza-s-indacene (3,5-diformyl-BODIPY) can be used as an efficient biofunctional cross-linker to generate a new class of chitosan-based hydrogels with fluorescence resonance energy transfer (FRET) dynamics and good solubility in water. The hydrogel was fully characterized by FT-IR, UV-vis, fluorescence, FE-SEM, AFM, rheology and picosecond time-resolved spectroscopic techniques. The self-healing ability was demonstrated by rheological recovery and macroscopic and microscopic observations...
October 17, 2017: Photochemical & Photobiological Sciences
Pasquale Sacco, Franco Furlani, Michela Cok, Andrea Travan, Massimiliano Borgogna, Eleonora Marsich, Sergio Paoletti, Ivan Donati
The present manuscript explored the effect of boric acid on Chitlac, a lactose-modified chitosan which had previously shown interesting biological and physical-chemical features. The herewith-reported experimental evidences demonstrated that boric acid binds to Chitlac, producing conformational and association effects on the chitosan derivative. The thermodynamics of boric acid binding to Chitlac was explored by means of 11B-NMR, Circular Dichroism (CD) and UV-Vis spectroscopy, while macromolecular effects were investigated by means of viscometry and Dynamic Light Scattering (DLS)...
October 17, 2017: Biomacromolecules
Jemima Daniela Dias Moraes, Silvana Raquel Alina Bertolino, Silvia Lucia Cuffini, Diego Fernando Ducart, Pedro Eriberto Bretzke, Gislaine Ricci Leonardi
Clay minerals are layered materials with a number of peculiar properties, which find many relevant applications in various industries. Since they are easily found everywhere, they are particularly attractive due to their economic viability. In the cosmetic industry, clay minerals are often used as excipients to stabilize emulsions or suspensions and to modify the rheological behavior of these systems. They also play an important role as adsorbents or absorbents, not only in cosmetics but also in other industries, such as pharmaceuticals...
October 13, 2017: International Journal of Pharmaceutics
Xufeng Wang, Maomao Zeng, Fang Qin, Benu Adhikari, Zhiyong He, Jie Chen
The effects of CaSO4-induced pre-aggregation on the rheological and structural properties of soy protein isolate (SPI) emulsion gels were investigated. As the Ca(2+) concentration during pre-aggregation increased (from 0mM to 7.5mM), the elastic modulus of the gels showed substantial increase, indicating stiffer gel structures. Large-deformation rheology suggested stronger but more brittle networks formed at higher Ca(2+) concentration during pre-aggregation. However, when the pre-aggregated Ca(2+) concentration reached 10mM, the corresponding gel became weaker...
March 1, 2018: Food Chemistry
Cheng-Mei Liu, Xiao-Hong He, Rui-Hong Liang, Wei Liu, Wen-Li Guo, Jun Chen
This study aims to analyze the effect of physicochemical properties of alginate-high methoxyl pectin (HMP)complexes on their performance as drug delivery systems.Rheology, textural propertiesand swelling behavior of alginate-HMP complexes were determined. HMP alone showed weak gelling ability.As ratio of alginate increased, gel capability, hardness and adhesiveness of gels increased, but swelling rate decreased. Bovine serum albumin (BSA) was used as a model drug and entrapped in the alginate-HMP beads. Morphology of beads was correlated with adhesiveness...
October 17, 2017: Journal of Biomaterials Science. Polymer Edition
Harrison T Pajovich, Ipsita A Banerjee
Fucoidan (Fuc), a natural polysaccharide derived from brown seaweed algae, and gelatin (Gel) were conjugated to form a template for preparation of biomimetic scaffolds for potential applications in bone tissue regeneration. To the Fuc-Gel we then incorporated the peptide sequence MTNYDEAAMAIASLN (MTN) derived from the E-F hand domain, known for its calcium binding properties. To mimic the components of the extracellular matrix of bone tissue, the Fuc-Gel-MTN assemblies were incubated in simulated body fluid (SBF) to induce biomineralization, resulting in the formation of β-tricalcium phosphate, and hydroxyapatite (HAp)...
September 20, 2017: Journal of Functional Biomaterials
Anita Mester, Zsuzsanna Magyar, Viktoria Sogor, Bence Tanczos, Yoav Stark, Konstantin Cherniavsky, Laszlo Bidiga, Katalin Peto, Norbert Nemeth
BACKGROUND: Intestinal ischemia-reperfusion (I/R) is a potentially life-threatening situation and its pathomechanism is not fully understood yet. OBJECTIVE: To investigate the early micro-rheological, microcirculatory and morphological consequences of intestinal I/R in a rat model. METHODS: CD rats were anesthetized and subjected to Control (n = 7) or I/R (n = 7) groups. Left femoral artery cannulation and median laparotomy were performed...
October 7, 2017: Clinical Hemorheology and Microcirculation
Lian Bai, Radhika Sharma, Xiang Cheng, Christopher W Macosko
Selective localization of graphene in cocontinuous polymer blends is an attractive method for preparing conductive polymer composites. Localization of graphene at the interface between the two polymer phases produces conductivity at the lowest concentration. Although graphene localization ultimately depends on thermodynamic factors such as the surface energy of graphene and the two polymer components, kinetics also strongly affects the migration and localization of graphene in polymer blends during melt compounding...
October 16, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
Jincy Joy, Jessica Pereira, Rachida Aid-Launais, Graciela Pavon-Djavid, Alok R Ray, Didier Letourneur, Anne Meddahi-Pellé, Bhuvanesh Gupta
The present work deals with the fabrication of electrospun tubular scaffold based on in-situ crosslinked blend of gelatin - oxidized carboxymethyl cellulose (OCMC) for vascular tissue engineering. The flow behavior and spinability of the hydrogel despite the in-situ crosslinked gelatin chains evaluated by Raman spectroscopic studies and rheological studies was utilized for electrospinning. The study highlights the tunable pore size and fiber diameter of the nanofibers with the manipulation of electrospinning parameters...
October 12, 2017: International Journal of Biological Macromolecules
Lihua Lin, Mingyue Shen, Suchen Liu, Wei Tang, Zhijun Wang, Mingyong Xie, Jianhua Xie
Polysaccharide from Mesona chinensis is becoming increasingly attractive focus because of its gelling property and biological activities. In this study, the rheological properties of an acidic heteropolysaccharide from Mesona chinensis (MCP) were investigated in dilute and semidilute solutions. Dynamic rheology was systematically conducted to investigate the effects of concentration, temperature, pH values, salts and freeze-thaw variations on the rheological properties of MCP. Results showed that the rheological properties of MCP exhibited pseudoplastic characteristic and "gel-like" behaviour by the flow behavior detection...
October 12, 2017: International Journal of Biological Macromolecules
D Casamassima, M Palazzo, M Nardoia, A G D'Alessandro, F Vizzarri
The effect of water restriction on body weight, body condition score, milk yield, and milk composition and rheological characteristics in intensively reared Lacaune ewes was evaluated. After 7 days of adaptation, the trial lasted 28 days. Thirty lactating ewes (48 ± 5 months of age; mean value ± standard deviation) at the beginning of third lactation month were divided into three groups (n = 10), corresponding to the following water restriction treatment: a group control received no drinking water restriction (W100), and two groups received water to the extent of 80% and 60% of W100 daily consumption (W80 and W60 group respectively)...
October 13, 2017: Journal of Animal Physiology and Animal Nutrition
Dong Cao, Hongxia Wang, Bo Zhang, Baolong Liu, Dengcai Liu, Wenjie Chen, Huaigang Zhang
Avenin-like storage proteins influence the rheological properties and processing quality in common wheat, and the discovery of new alleles will benefit wheat quality improvement. In this study, 13 avenin-like b alleles (TaALPb7D-A-M) were discovered in 108 Aegilops tauschii Coss. accessions. Ten alleles were reported for the first time, while the remaining three alleles were the same as alleles in other species. A total of 15 nucleotide changes were detected in the 13 alleles, resulting in only 11 amino acid changes because of synonymous mutations...
October 13, 2017: Genetica
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