Dumitru Ciolac, Gabriel Gonzalez-Escamilla, Yaroslav Winter, Nico Melzer, Felix Luessi, Angela Radetz, Vinzenz Fleischer, Stanislav A Groppa, Michael Kirsch, Stefan Bittner, Frauke Zipp, Muthuraman Muthuraman, Sven G Meuth, Matthias Grothe, Sergiu Groppa
BACKGROUND: To investigate the relevance of compartmentalized grey matter (GM) pathology and network reorganization in MS patients with concomitant epilepsy. METHODS: From 3T MRI scans of 30 MS patients with epilepsy (MSE; age 41±15 years, 21 females, disease duration 8±6 years, median Expanded Disability Status Scale (EDSS) 3), 60 MS patients without epilepsy (MS; age 41±12 years, 35 females, disease duration 6±4 years, EDSS 2), and 60 healthy subjects (HS; age 40±13 years, 27 females) regional volumes of GM lesions and of cortical, subcortical, and hippocampal structures were quantified...
May 18, 2022: European Journal of Neurology