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https://www.readbyqxmd.com/read/29334123/cancer-associated-fibroblasts-tailored-tumor-microenvironment-of-therapy-resistance-in-gastrointestinal-cancers
#1
REVIEW
Yeqi Sun, Ruifen Wang, Meng Qiao, Yanchun Xu, Wenbin Guan, Lifeng Wang
Gastrointestinal cancers (GI) are a group of highly aggressive malignancies with heavy cancer-related mortalities. Even if continued development of therapy methods, therapy resistance has been a great obstruction for cancer treatment and thereby inevitably leads to depressed final mortality. Peritumoral cancer associated fibroblasts (CAFs), a versatile population assisting cancer cells to build a facilitated tumor microenvironment (TME), has been demonstrated exerting a promotion influence on cancer proliferation, migration, invasion, metastasis and also therapy resistance...
January 15, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29330232/interventions-must-be-realistic-to-be-useful-and-completed-in-family-medicine
#2
EDITORIAL
Marjorie A Bowman, Dean A Seehusen, Anne Victoria Neale
Being realistic while helping our patients is this issue's theme. Given the volume of tasks required in family medicine, recommendations for improvements in direct care or care measurement cannot just be evidence-based but must also be realistic. On the list of realistic: ordering antipsychotics for symptoms of dementia in the elderly, despite recommendations to not do so; ordering antidepressants without fear that the patient could develop hypertension; mental health care providers in primary care offices; forced choice for opioid management; plus agenda setting for visit efficiency...
January 2018: Journal of the American Board of Family Medicine: JABFM
https://www.readbyqxmd.com/read/29320600/providing-physicians-with-feedback-on-medication-adherence-for-people-with-chronic-diseases-taking-long-term-medication
#3
REVIEW
Vincent Zaugg, Virginie Korb-Savoldelli, Pierre Durieux, Brigitte Sabatier
BACKGROUND: Poor medication adherence decreases treatment efficacy and worsens clinical outcomes, but average rates of adherence to long-term pharmacological treatments for chronic illnesses are only about 50%. Interventions for improving medication adherence largely focus on patients rather than on physicians; however, the strategies shown to be effective are complex and difficult to implement in clinical practice. There is a need for new care models addressing the problem of medication adherence, integrating this problem into the patient care process...
January 10, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29316297/prevalence-defining-characteristics-and-related-factors-of-the-nursing-diagnosis-of-anxiety-in-hospitalized-medical-surgical-patients
#4
Gianfranco Sanson, Annalisa Perrone, Adriana Fascì, Fabio D'Agostino
PURPOSE: To document the prevalence of the nursing diagnosis of anxiety in hospital patients, based on its level of severity, defining characteristics (DCs), and other related factors, and to identify the key DCs that serve as predictors of clinically significant anxiety (CSA). DESIGN: Cross-sectional study. We enrolled 116 consecutive adult patients hospitalized from October 10 to 16, 2016, in medical-surgical wards within the first 48 hr of admission. METHODS: The potential DCs and related factors of anxiety were collected based on the NANDA International terminology...
January 8, 2018: Journal of Nursing Scholarship
https://www.readbyqxmd.com/read/29306891/community-pharmacists-services-for-women-during-pregnancy-and-breast-feeding-in-kuwait-a-cross-sectional-study
#5
Abdullah Albassam, Abdelmoneim Awad
OBJECTIVES: This study was designed to identify the services provided by community pharmacists in Kuwait and their views regarding self-care in pregnancy and lactation. In addition, it determined the pharmacists' recommendations for treatment of pregnancy-related and breast feeding-related ailments. DESIGN: Cross-sectional questionnaire-based survey. SETTING: Community pharmacies in Kuwait. PARTICIPANTS: 207 pharmacies were randomly selected from the Ministry of Health database...
January 5, 2018: BMJ Open
https://www.readbyqxmd.com/read/29305633/-globalization-in-medical-research
#6
REVIEW
H-J Ehni, U Wiesing
The globalization of clinical research is gaining momentum. In particular, emerging countries, such as Brazil, India, Russia and South Africa show a significant increase in clinical trials. This trend is generating various ethical problems, which are examined in the present article. Sometimes, generally accepted ethical rules, such as the evaluation of clinical trials by ethics commissions are not respected and sometimes conflicts are generated which are difficult to resolve. For instance, it is controversial which standard of care researchers and sponsors have to provide in an international study...
January 5, 2018: Der Chirurg; Zeitschrift Für Alle Gebiete der Operativen Medizen
https://www.readbyqxmd.com/read/29301111/a-deep-learning-framework-for-causal-shape-transformation
#7
Kin Gwn Lore, Daniel Stoecklein, Michael Davies, Baskar Ganapathysubramanian, Soumik Sarkar
Recurrent neural network (RNN) and Long Short-term Memory (LSTM) networks are the common go-to architecture for exploiting sequential information where the output is dependent on a sequence of inputs. However, in most considered problems, the dependencies typically lie in the latent domain which may not be suitable for applications involving the prediction of a step-wise transformation sequence that is dependent on the previous states only in the visible domain with a known terminal state. We propose a hybrid architecture of convolution neural networks (CNN) and stacked autoencoders (SAE) to learn a sequence of causal actions that nonlinearly transform an input visual pattern or distribution into a target visual pattern or distribution with the same support and demonstrated its practicality in a real-world engineering problem involving the physics of fluids...
December 18, 2017: Neural Networks: the Official Journal of the International Neural Network Society
https://www.readbyqxmd.com/read/29285857/update-on-research-and-application-of-problem-based-learning-in-medical-science-education
#8
Chuifeng Fan, Biying Jiang, Xiuying Shi, Enhua Wang, Qingchang Li
Problem-based learning (PBL) is a unique form of pedagogy dedicated to developing students' self-learning and clinical practice skills. After several decades of development, although applications vary, PBL has been recognized all over the world and implemented by many medical schools. This review summarizes and updates the application and study of PBL in medical education through the literature published between 1993 and early 2017. It focuses on understanding real medical PBL courses and ways to improve PBL to achieve better learning outcomes...
December 29, 2017: Biochemistry and Molecular Biology Education
https://www.readbyqxmd.com/read/29278620/95th-anniversary-of-pathophysiology-in-croatia
#9
Zdenko Kovač
University level of Pathophysiology research and teaching in Croatia had started with the third year of Medical School of Zagreb in academic year 1919./20. Ever since, despite historical changes of the main university stake holder, the state of Croatia, Department of Pathophysiology development progressed and has made visible academic achievements, with a broader effect in medical community. The first 95 years of academic tradition and major achievements are shortly described in this paper. Professor Miroslav Mikuličić envisioned Pathophysiology in close relations with Pharmacology and made the pioneering steps of establishing the "double" department at Šalata...
December 2017: Psychiatria Danubina
https://www.readbyqxmd.com/read/29262486/-association-between-elective-cesarean-section-and-infants-developmental-behaviors-a-cohort-study
#10
Y F Sun, K Huang, Y B Hu, H Gao, Y Niu, X Y Tao, R W Tao, P Zhu, F B Tao
Objective: To investigate the effect of elective cesarean section (ECS) on infants' developmental behaviors. Methods: A total of 3 474 pregnant women living in Ma'anshan more than 6 months and accepting obstetric examination in Ma'anshan Maternal and Child Care Center were recruited from May 2013 to September 2014. Excluding participants with pregnancy termination (162), twin pregnancy (39), assisted delivery (14), emergency cesarean section (76) and unclear delivery mode (141), 3 042 pair of mother and infant entered the final analysis...
December 6, 2017: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
https://www.readbyqxmd.com/read/29250306/a-3d-scan-model-and-thermal-image-data-fusion-algorithms-for-3d-thermography-in-medicine
#11
Adam Chromy, Ondrej Klima
Objectives: At present, medical thermal imaging is still considered a mere qualitative tool enabling us to distinguish between but lacking the ability to quantify the physiological and nonphysiological states of the body. Such a capability would, however, facilitate solving the problem of medical quantification, whose presence currently manifests itself within the entire healthcare system. Methods: A generally applicable method to enhance captured 3D spatial data carrying temperature-related information is presented; in this context, all equations required for other data fusions are derived...
2017: Journal of Healthcare Engineering
https://www.readbyqxmd.com/read/29247874/a-novel-nonlinear-parameter-estimation-method-of-soft-tissues
#12
Qianqian Tong, Zhiyong Yuan, Mianlun Zheng, Xiangyun Liao, Weixu Zhu, Guian Zhang
The elastic parameters of soft tissues are important for medical diagnosis and virtual surgery simulation. In this study, we propose a novel nonlinear parameter estimation method for soft tissues. Firstly, an in-house data acquisition platform was used to obtain external forces and their corresponding deformation values. To provide highly precise data for estimating nonlinear parameters, the measured forces were corrected using the constructed weighted combination forecasting model based on a support vector machine (WCFM_SVM)...
December 13, 2017: Genomics, Proteomics & Bioinformatics
https://www.readbyqxmd.com/read/29236970/seen-through-the-patients-eyes-quality-of-chronic-illness-care
#13
Melissa Desmedt, Sonja Vertriest, Mirko Petrovic, Jochen Bergs, Hubertus Vrijhoef, Ezra Dessers, Johan Hellings, Dominique Vandijck
Background: Most well-developed healthcare systems are facing the challenge of managing the increasing prevalence of patients with chronic diseases. Comprehensive frameworks, such as the chronic care model (CCM), receive widespread acceptance for improving care processes, clinical outcomes and costs. Objective: The purpose of this study was to explore chronic patients' perceptions of the quality of chronic care and the alignment with the CCM. Since previous research indicated that a patient's assessment may depend on socio-demographic or disease-related characteristics, the relationship between the mean Patient Assessment of Chronic Illness Care (PACIC) score and possible aforementioned predictors was also explored...
December 10, 2017: Family Practice
https://www.readbyqxmd.com/read/29235746/clinical-problem-solving-a-tobacco-merchant-who-can-t-spit
#14
Sandra Benizri, Nancy Agmon-Levin, Noam D Kitrey, Dan Carter, Elinor Goshen, Yehonathan Sharabi
A 47 year old man presented with a combination of dry mouth and lightheadedness while standing. His medical background was unremarkable except for cigarette smoking and hyperlipidemia. Sjögren's syndrome was ruled out, and he was referred for evaluation of orthostatic hypotension, which by then included syncopal episodes and injuries. Additional symptoms included dry eyes, constipation, reduced sweating, and erectile dysfunction. After excluding medications and structural cardiac abnormalities as causes of orthostatic hypotension, a clinical autonomic evaluation was performed...
December 2017: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/29233441/professional-and-pre-professional-pharmacy-students-perceptions-of-team-based-learning-tbl-at-a-private-research-intensive-university
#15
Danielle M Miller, Karen Khalil, Olivia Iskaros, Jenny A Van Amburgh
BACKGROUND AND PURPOSE: Pharmacy students need to develop critical thinking and problem-solving skills as well as be a valuable team member. The use of team based learning (TBL) fosters effective team collaboration, enables continuous active and self-directed learning, and requires both individual and team accountability. The purpose was to evaluate pharmacy students' perceptions and experiences related to TBL in different years of the pharmacy curriculum. EDUCATIONAL ACTIVITY AND SETTING: Two classes, Introduction to the Profession of Pharmacy (intro), a required course, and Self-Care/Non-Prescription Medications (self-care), an elective course, utilize the TBL approach...
July 2017: Currents in Pharmacy Teaching & Learning
https://www.readbyqxmd.com/read/29233385/traditional-lecture-versus-jigsaw-learning-method-for-teaching-medication-therapy-management-mtm-core-elements
#16
Jennifer A Wilson, Angela H Pegram, Dawn M Battise, April M Robinson
BACKGROUND AND PURPOSE: To determine if traditional didactic lecture or the jigsaw learning method is more effective to teach the medication therapy management (MTM) core elements in a first year pharmacy course. EDUCATIONAL ACTIVITY AND SETTING: Traditional didactic lecture and a pre-class reading assignment were used in the fall semester cohort, and the jigsaw method was used in the spring semester cohort. Jigsaw is a cooperative learning strategy requiring students to assume responsibility for learning, and subsequently teaching peers...
November 2017: Currents in Pharmacy Teaching & Learning
https://www.readbyqxmd.com/read/29233313/pharmacy-student-involvement-in-a-transition-of-care-program
#17
Raquel Hertig, Rina Ackerman, Brenda Zagar, Serina Tart
BACKGROUND AND PURPOSE: Cape Fear Valley Medical Center (CFVMC) implemented a Community Paramedic Program (CPP) to improve the transition of hospitalized patients to the home setting. In this program, paramedics conduct home visits for 30 days after qualifying patients are discharged. This article describes pharmacy services provided to CPP patients by fourth-year pharmacy students on Advanced Pharmacy Practice Experiences (APPE) that assisted with home visits. EDUCATIONAL ACTIVITY AND SETTING: Students were oriented to the CPP and patient interview technique was assessed through a role-play scenario...
September 2017: Currents in Pharmacy Teaching & Learning
https://www.readbyqxmd.com/read/29228528/the-dilemma-of-irrational-antibiotic-and-corticosteroid-prescription-in-iran-how-much-it-can-affect-the-medicine-expenditures
#18
Parisa Mehdizadeh, Nooredin Dopeykar, Mohammad Meskarpour-Amiri, Hediyeh Zekri, Mahmoud Salesi
In recent years the high cost of medicines and the lack of it were one of the major problems in developing countries that despite numerous efforts to solve the root causes of this problem, the issue remains, unfortunately. Therefore, this study aimed to assess the impact of antibiotics and corticosteroids prescription on the medicines expenditures. This was descriptive-analytical study that conducted to assess the function of medical expenditures through prescription letters and analysis the factors affecting medicine expenditures...
October 2017: Acta Medica Iranica
https://www.readbyqxmd.com/read/29227267/-problems-of-immunization-and-shared-responsibility-at-the-level-of-primary-healthcare
#19
Y Uteuliyev, A Amenov, A Asen, A Saktapov, N Iskakova, U Amanzholova
In this article, the authors consider ways to solve problematic issues related to the organization and conduct of immunization among the population in order to prevent vaccine-preventable infectious diseases. An in-depth analysis of the progress of vaccine prevention has been conducted and the results achieved in the world in recent years are reflected. At the same time, the authors identified problematic issues related to the successful implementation of further work on the prevention of vaccine-preventable infectious diseases...
November 2017: Georgian Medical News
https://www.readbyqxmd.com/read/29205440/effect-of-reflection-on-medical-students-situational-interest-an-experimental-study
#20
Ligia M C Ribeiro, Silvia Mamede, Alexandre S Moura, Eliza M de Brito, Rosa M D de Faria, Henk G Schmidt
CONTEXT: Reflection has been considered crucial to learning. Engaging in reflection while solving problems is expected to foster identification of knowledge gaps and interest in learning more about them, the latter being a major motivational force in learning. Although theoretically sound, this assumption still lacks empirical evidence. This experiment investigated whether reflection while diagnosing clinical cases of different levels of difficulty influences medical students' awareness of knowledge gaps and situational interest...
December 4, 2017: Medical Education
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