keyword
MENU ▼
Read by QxMD icon Read
search

molecular evolution

keyword
https://www.readbyqxmd.com/read/29779206/old-new-and-emerging-immunohistochemical-markers-in-pheochromocytoma-and-paraganglioma
#1
REVIEW
Veronica K Y Cheung, Anthony J Gill, Angela Chou
The evolution of genetic research over the past two decades has greatly improved the understanding of pheochromocytomas and paragangliomas. It is now accepted that more than one third of pheochromocytoma and paragangliomas arise in the context of syndromic disease, usually hereditary. The genetic profile of these tumors also has important prognostic implications which may help guide treatment. Accompanying the changing molecular landscape is the development of new immunohistochemical markers. Initially used in assisting with diagnosis, immunohistochemical markers have now become an important adjunct to screening programs for inherited conditions and subsequently as prognostic markers...
May 19, 2018: Endocrine Pathology
https://www.readbyqxmd.com/read/29778877/an-insight-into-the-multi-scale-structures-and-pasting-behaviors-of-starch-following-citric-acid-treatment
#2
Yinqiang Huo, Binjia Zhang, Meng Niu, Caihua Jia, Siming Zhao, Qilin Huang, Hongying Du
Using combined analytical techniques, this work discloses how citric acid (CA) treatment affects the pasting features of starch from a view of multi-scale structural evolutions. The treatment induced disruption events in starch multi-level structures and thus modulated the pasting behaviors. A structure-property relationship was proposed to rationalize CA effects on starch pasting properties. Specifically, CA disrupted starch structures from molecular scale to micron scale, eventually reducing pasting temperature and paste viscosities...
May 17, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29778724/a-tangle-of-forms-and-phylogeny-extensive-morphological-homoplasy-and-molecular-clock-heterogeneity-in-bonnetina-and-related-tarantulas
#3
David Ortiz, Oscar F Francke, Jason E Bond
Tarantula spider systematics has long been considered problematic. Species diagnosis and phylogenetic hypotheses have historically relied on morphological features, which are known to be relatively conserved and/or highly homoplastic across the family. Morphology-based attempts to clarify the phylogeny of the highly diverse New World Theraphosinae, have only been moderately successful, and the time-frame of tarantulas' evolution is nearly terra incognita. Here we present a molecular phylogenetic analysis of the Theraphosinae genus Bonnetina and related lineages, employing one mitochondrial (COI) and five nuclear (ITS1, EF1G, MID1IP1, MRPL44, and I3568) loci...
May 17, 2018: Molecular Phylogenetics and Evolution
https://www.readbyqxmd.com/read/29777767/biglycan-is-a-new-high-affinity-ligand-for-cd14-in-macrophages
#4
Heiko Roedig, Madalina V Nastase, Helena Frey, Kristin Moreth, Jinyang Zeng-Brouwers, Chiara Poluzzi, Louise Tzung-Harn Hsieh, Christian Brandts, Simone Fulda, Malgorzata Wygrecka, Liliana Schaefer
Sterile inflammation is a therapeutic target in many diseases where it represents an important initiator of disease progression. However, the detailed mechanisms underlying its evolution and biological relevance are not yet completely elucidated. Biglycan, a prototype extracellular matrix-derived damage-associated molecular pattern, mediates sterile inflammation in macrophages through Toll-like receptor (TLR) 2 and/or TLR4-dependent signaling pathways. Here we discovered that soluble biglycan is a novel high-affinity ligand for CD14, a well-known GPI-anchored co-receptor for TLRs...
May 16, 2018: Matrix Biology: Journal of the International Society for Matrix Biology
https://www.readbyqxmd.com/read/29777157/transient-metal-centered-states-mediate-isomerization-of-a-photochromic-ruthenium-sulfoxide-complex
#5
Amy A Cordones, Jae Hyuk Lee, Kiryong Hong, Hana Cho, Komal Garg, Martial Boggio-Pasqua, Jeffrey J Rack, Nils Huse, Robert W Schoenlein, Tae Kyu Kim
Ultrafast isomerization reactions underpin many processes in (bio)chemical systems and molecular materials. Understanding the coupled evolution of atomic and molecular structure during isomerization is paramount for control and rational design in molecular science. Here we report transient X-ray absorption studies of the photo-induced linkage isomerization of a Ru-based photochromic molecule. X-ray spectra reveal the spin and valence charge of the Ru atom and provide experimental evidence that metal-centered excited states mediate isomerization...
May 18, 2018: Nature Communications
https://www.readbyqxmd.com/read/29776632/molecular-diagnosis-of-hematopoietic-neoplasms-2018-update
#6
REVIEW
Radhakrishnan Ramchandren, Tarek Jazaerly, Martin H Bluth, Ali M Gabali
Diagnosis of hematologic malignancies have matured to encompass molecular as well as phenotypic characteristics. Cytogenetic abnormalities are considered common events in this regard. These abnormalities generally consist of structural chromosomal abnormalities or gene mutations, which often are integral to the pathogenesis and subsequent evolution of an individual malignancy. Improvements made in identifying and interpreting these molecular alterations have resulted in advances in the diagnosis, prognosis, monitoring, and therapy for cancer...
June 2018: Clinics in Laboratory Medicine
https://www.readbyqxmd.com/read/29776407/comparative-genomics-of-the-miniature-wasp-and-pest-control-agent-trichogramma-pretiosum
#7
Amelia R I Lindsey, Yogeshwar D Kelkar, Xin Wu, Dan Sun, Ellen O Martinson, Zhichao Yan, Paul F Rugman-Jones, Daniel S T Hughes, Shwetha C Murali, Jiaxin Qu, Shannon Dugan, Sandra L Lee, Hsu Chao, Huyen Dinh, Yi Han, Harsha Vardhan Doddapaneni, Kim C Worley, Donna M Muzny, Gongyin Ye, Richard A Gibbs, Stephen Richards, Soojin V Yi, Richard Stouthamer, John H Werren
BACKGROUND: Trichogrammatids are minute parasitoid wasps that develop within other insect eggs. They are less than half a millimeter long, smaller than some protozoans. The Trichogrammatidae are one of the earliest branching families of Chalcidoidea: a diverse superfamily of approximately half a million species of parasitoid wasps, proposed to have evolved from a miniaturized ancestor. Trichogramma are frequently used in agriculture, released as biological control agents against major moth and butterfly pests...
May 18, 2018: BMC Biology
https://www.readbyqxmd.com/read/29776375/range-wide-genetic-analysis-of-dermacentor-variabilis-and-its-francisella-like-endosymbionts-demonstrates-phylogeographic-concordance-between-both-taxa
#8
Emily L Kaufman, Nathan E Stone, Glen A Scoles, Crystal M Hepp, Joseph D Busch, David M Wagner
BACKGROUND: The American dog tick, Dermacentor variabilis, is an important vector of pathogens to humans, wildlife and domestic animals in North America. Although this tick species is widely distributed in the USA and Canada, knowledge of its range-wide phylogeographic patterns remains incomplete. METHODS: We carried out a phylogenetic analysis of D. variabilis using samples collected from 26 USA states and five Canadian provinces. Tick samples (n = 1053 in total) originated from two main sources: existing archives (2000-2011), and new collections made from 2012 to 2013...
May 18, 2018: Parasites & Vectors
https://www.readbyqxmd.com/read/29775319/operando-evidence-for-a-universal-oxygen-evolution-mechanism-on-thermal-and-electrochemical-iridium-oxides
#9
Viktoriia A Saveleva, Li Wang, Detre Teschner, Travis E Jones, Aldo S Gago, K Andreas Friedrich, Spyridon Zafeiratos, Robert Schloegl, Elena R Savinova
Progress in the development of the proton exchange membrane (PEM) water electrolysis technology requires decreasing the anode overpotential, where the sluggish multistep oxygen evolution reaction (OER) occurs. This calls for the understanding of the nature of the active OER sites and reaction intermediates, which are still being debated. In this work, we apply synchrotron radiation - based near ambient pressure X-ray photoelectron and absorption spectroscopies under operando conditions in order to unveil the nature of the reaction intermediates and shed light on the OER mechanism on electrocatalysts most widely used in PEM electrolyzers - electrochemical and thermal iridium oxides...
May 18, 2018: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/29774338/trace-metals-in-oysters-molecular-and-cellular-mechanisms-and-ecotoxicological-impacts
#10
REVIEW
Wen-Xiong Wang, Jie Meng, Nanyan Weng
Oysters are important benthic bivalves in coastal and estuarine environments. They are widely farmed due to their rapid growth and taste; they are also widely applied in environmental monitoring of coastal pollution due to their accumulation of contaminants. Most importantly, oysters are among the few marine organisms that are considered to be hyper-accumulators of many toxic metals, such as cadmium, copper and zinc. As such, there is a tremendous call to study the interactions between metals and oysters, especially due to the increasing metal pollution in many coastal and estuarine waters...
May 18, 2018: Environmental Science. Processes & Impacts
https://www.readbyqxmd.com/read/29773785/revealing-isoelectronic-size-conversion-dynamics-of-metal-nanoclusters-by-a-noncrystallization-approach
#11
Qiaofeng Yao, Victor Fung, Cheng Sun, Sida Huang, Tiankai Chen, De-En Jiang, Jim Yang Lee, Jianping Xie
Atom-by-atom engineering of nanomaterials requires atomic-level knowledge of the size evolution mechanism of nanoparticles, which remains one of the greatest mysteries in nanochemistry. Here we reveal atomic-level dynamics of size evolution reaction of molecular-like nanoparticles, i.e., nanoclusters (NCs) by delicate mass spectrometry (MS) analyses. The model size-conversion reaction is [Au23 (SR)16 ]- → [Au25 (SR)18 ]- (SR = thiolate ligand). We demonstrate that such isoelectronic (valence electron count is 8 in both NCs) size-conversion occurs by a surface-motif-exchange-induced symmetry-breaking core structure transformation mechanism, surfacing as a definitive reaction of [Au23 (SR)16 ]-  + 2 [Au2 (SR)3 ]- → [Au25 (SR)18 ]-  + 2 [Au(SR)2 ]- ...
May 17, 2018: Nature Communications
https://www.readbyqxmd.com/read/29772506/slow-pyrolysis-polygeneration-of-bamboo-phyllostachys-pubescens-product-yield-prediction-and-biochar-formation-mechanism
#12
Huihui Wang, Xin Wang, Yanshan Cui, Zhongcai Xue, Yuxin Ba
Slow pyrolysis of bamboo was conducted at 400-600 °C and pyrolysis products were characterized with FTIR, BET, XRD, SEM, EDS and GC to establish a pyrolysis product yield prediction model and biochar formation mechanism. Pyrolysis biochar yield was predicted based on content of cellulose, hemicellulose and lignin in biomass with their carbonization index of 0.20, 0.35 and 0.45. The formation mechanism of porous structure in pyrolysis biochar was established based on its physicochemical property evolution and emission characteristics of pyrolysis gas...
May 11, 2018: Bioresource Technology
https://www.readbyqxmd.com/read/29772374/evolution-expression-and-characterisation-of-liver-expressed-antimicrobial-peptide-genes-in-ancient-chondrostean-sturgeons
#13
Shuhuan Zhang, Qiaoqing Xu, Hao Du, Zhitao Qi, Youshen Li, Jun Huang, Jun Di, Qiwei Wei
Liver-expressed antimicrobial peptide 2 (leap-2) is an evolutionarily ancient molecule that acts as the key component in vertebrate innate immunity against invading pathogens. Leap-2 has been identified and characterised in several teleosts, but not yet in chondrosteans. Herein, the complete coding sequences of leap-2b and leap-2c were identified from expressed sequence tags (ESTs) isolated from Dabry's sturgeon (Acipenser dabryanus) and Chinese sturgeon (A. sinensis), designated as adleap-2b, adleap-2c, asleap-2b, and asleap-2c, respectively...
May 14, 2018: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29772096/signatures-of-diversifying-selection-and-convergence-acting-on-passerine-toll-like-receptor-4-in-an-evolutionary-context
#14
Tereza Králová, Tomáš Albrecht, Josef Bryja, David Hořák, Arild Johnsen, Jan T Lifjeld, Marian Novotný, Ondřej Sedláček, Hana Velová, Michal Vinkler
Positive selection acting on Toll-like receptors (TLRs) has been recently investigated to reveal evolutionary mechanisms of host-pathogen molecular co-adaptation. Much of this research, however, has focused mainly on the identification of sites predicted to be under positive selection, bringing little insight into the functional differences and similarities among species and a limited understanding of convergent evolution in the innate immune molecules. In this study we provide evidence of phenotypic variability in the avian TLR4 ligand-binding region (LBR), the direct interface between host and pathogen molecular structures...
May 17, 2018: Molecular Ecology
https://www.readbyqxmd.com/read/29772073/julius-sachs-1868-the-father-of-plant-physiology
#15
Ulrich Kutschera, Karl J Niklas
The year 2018 marks the 150th anniversary of the first publication of Julius von Sachs' (1832-1897) Lehrbuch der Botanik (Textbook of Botany), which provided a comprehensive summary of what was then known about the plant sciences. Three years earlier, in 1865, Sachs produced the equally impressive Handbuch der Experimental-Physiologie der Pflanzen (Handbook of Experimental Plant Physiology), which summarized the state of knowledge in all aspects of the discipline known today as plant physiology. Both of these books provided numerous insights based on Sachs' seminal experiments...
May 17, 2018: American Journal of Botany
https://www.readbyqxmd.com/read/29771985/another-cat-and-mouse-game-deciphering-the-evolution-of-the-scgb-superfamily-and-exploring-the-molecular-similarity-of-major-cat-allergen-fel-d-1-and-mouse-abp-using-computational-approaches
#16
Rajesh Durairaj, Patrick Pageat, Cécile Bienboire-Frosini
The mammalian secretoglobin (SCGB) superfamily contains functionally diverse members, among which the major cat allergen Fel d 1 and mouse salivary androgen-binding protein (ABP) display similar subunits. We searched for molecular similarities between Fel d 1 and ABP to examine the possibility that they play similar roles. We aimed to i) cluster the evolutionary relationships of the SCGB superfamily; ii) identify divergence patterns, structural overlap, and protein-protein docking between Fel d 1 and ABP dimers; and iii) explore the residual interaction between ABP dimers and steroid binding in chemical communication using computational approaches...
2018: PloS One
https://www.readbyqxmd.com/read/29771530/evolution-of-biocatalytic-and-chemocatalytic-c-h-functionalization-strategy-in-the-synthesis-of-manzacidin-c
#17
Christian R Zwick, Hans Renata
Due to their unique molecular architecture, the manzacidins have been the subject of intense synthetic efforts in the past two decades. Here, we describe two synthetic approaches towards manzacidin C that center on the enzymatic hydroxylation of unprotected L-leucine. This study also resulted in the discovery of novel synthetic methodologies, including a photocatalytic C-H azidation of unprotected amino acids. Additionally, we describe the use of hydroxylated L-leucine in the preparation of various densely-substituted pyrrolidines...
May 17, 2018: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/29770900/insights-into-mutation-effect-in-three-poikiloderma-with-neutropenia-patients-by-transcript-analysis-and-disease-evolution-of-reported-patients-with-the-same-pathogenic-variants
#18
Elisa A Colombo, Nursel H Elcioglu, Claudio Graziano, Pamela Farinelli, Elisabetta Di Fede, Iria Neri, Elena Facchini, Mariangela Greco, Cristina Gervasini, Lidia Larizza
PURPOSE: Poikiloderma with neutropenia (PN) is a genodermatosis currently described in 77 patients, all presenting with early-onset poikiloderma, neutropenia, and several additional signs. Biallelic loss-of-function mutations in USB1 gene are detected in all molecularly tested patients but genotype-phenotype correlation remains elusive. Cancer predisposition is recognized among PN features and pathogenic variants found in patients who developed early in life myelodysplasia (n = 12), acute myeloid leukemia (n = 2), and squamous cell carcinoma (n = 2) should be kept into account in management and follow-up of novel patients...
May 16, 2018: Journal of Clinical Immunology
https://www.readbyqxmd.com/read/29770590/genomic-and-antigenic-characterization-of-porcine-epidemic-diarrhoea-virus-strains-isolated-from-south-korea-2017
#19
Sunhee Lee, Changhee Lee
Porcine epidemic diarrhoea virus (PEDV) is a globally emerging and re-emerging enteric coronavirus in pigs causing serious economic threats to the world swine industry. Since the re-emergence of massive PEDV outbreaks in South Korea in 2013-2014, domestic pig farms have continued to experience PED epidemics or endemics. This study represents the molecular characterization of PEDV isolates identified in diarrhoeic animals collected across the country in 2017. Initial sequencing analysis of the full-length S genes revealed that 70% of the 2017 isolates (7/10) belong to the G2b subgroup, while the remaining isolates were classified as G1b...
May 16, 2018: Transboundary and Emerging Diseases
https://www.readbyqxmd.com/read/29770273/westwards-and-northwards-dispersal-of-triosteum-himalayanum-caprifoliaceae-from-the-hengduan-mountains-region-based-on-chloroplast-dna-phylogeography
#20
Hai-Rui Liu, Qing-Bo Gao, Fa-Qi Zhang, Gulzar Khan, Shi-Long Chen
The varying topography and environment that resulted from paleoorogeny and climate fluctuations of the Himalaya-Hengduan Mountains (HHM) areas had a considerable impact on the evolution of biota during the Quaternary. To understand the phylogeographic pattern and historical dynamics of Triosteum himalayanum (Caprifoliaceae), we sequenced three chloroplast DNA fragments ( rbcL-accD , rps15-ycf1 , and trnH-psbA ) from 238 individuals representing 20 populations. Nineteen haplotypes (H1-H19) were identified based on 23 single-site mutations and eight indels...
2018: PeerJ
keyword
keyword
69166
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"