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https://www.readbyqxmd.com/read/27712107/light-therapy-with-scheduled-rise-times-in-young-adults-with-delayed-sleep-phase-disorder-therapeutic-outcomes-and-possible-predictors
#1
Katarina Danielsson, Markus Jansson-Fröjmark, Jan-Erik Broman, Agneta Markström
Clinical trials with light therapy (LT) for delayed sleep phase disorder (DSPD) are sparse and little is known about factors that are favorable for improvements. In this study, LT with scheduled rise times was conducted at home for 14 days by 44 participants with DSPD aged 16-26 years. Primary outcomes were sleep onset and sleep offset. Potential predictors were demographic characteristics, chronotype, dim light melatonin onset, the number of days the LT lamp was used, the daily duration of LT, daytime sleepiness, anxiety, depression, worry, and rumination...
August 11, 2016: Behavioral Sleep Medicine
https://www.readbyqxmd.com/read/27692050/prevalence-of-circadian-misalignment-and-its-association-with-depressive-symptoms-in-delayed-sleep-phase-disorder
#2
Jade M Murray, Tracey L Sletten, Michelle Magee, Christopher Gordon, Nicole Lovato, Delwyn J Bartlett, David J Kennaway, Leon C Lack, Ronald R Grunstein, Steven W Lockley, Shantha M W Rajaratnam
STUDY OBJECTIVE: To examine the prevalence of circadian misalignment in clinically diagnosed DSPD, and compare mood and daytime functioning in those with and without a circadian basis for the disorder. METHODS: 182 DSPD patients aged 16 to 64 years, engaged in regular employment or school, underwent sleep-wake monitoring in the home, followed by a sleep laboratory visit for assessment of salivary dim light melatonin onset (DLMO). Based on the DLMO assessments, patients were classified into two groups: circadian DSPD, defined as DLMO occurring at or after desired bedtime, or non-circadian DSPD, defined as DLMO occurring before desired bedtime...
September 26, 2016: Sleep
https://www.readbyqxmd.com/read/27611743/can-the-circadian-phase-be-estimated-from-self-reported-sleep-timing-in-patients-with-delayed-sleep-wake-phase-disorder-to-guide-timing-of-chronobiologic-treatment
#3
Nicole Lovato, Gorica Micic, Michael Gradisar, Sally A Ferguson, Helen J Burgess, David J Kennaway, Leon Lack
INTRODUCTION: The efficacy of bright light and/or melatonin treatment for Delayed Sleep Wake Phase Disorder (DSWPD) is contingent upon an accurate clinical assessment of the circadian phase. However, the process of determining this circadian phase can be costly and is not yet readily available in the clinical setting. The present study investigated whether more cost-effective and convenient estimates of the circadian phase, such as self-reported sleep timing, can be used to predict the circadian phase and guide the timing of light and/or melatonin treatment (i...
2016: Chronobiology International
https://www.readbyqxmd.com/read/27537980/delayed-sleep-phase-disorder-in-a-swedish-cohort-of-adolescents-and-young-adults-prevalence-and-associated-factors
#4
Katarina Danielsson, Agneta Markström, Jan-Erik Broman, Lars von Knorring, Markus Jansson-Fröjmark
A delayed sleep-wake and circadian rhythm often occurs during puberty. While some individuals only develop a delayed sleep phase (DSP), others will fulfill the criteria for the diagnosis of delayed sleep phase disorder (DSPD). All previous studies have however not separated DSP from DSPD, and, as a result, the prevalence and associated factors are largely unknown for the two conditions individually. We estimated the prevalence of DSP and DSPD in a Swedish cohort of adolescents and young adults. We also investigated associated factors in the two conditions relative to each other and individuals with no DSP...
2016: Chronobiology International
https://www.readbyqxmd.com/read/27322730/wearing-blue-light-blocking-glasses-in-the-evening-advances-circadian-rhythms-in-the-patients-with-delayed-sleep-phase-disorder-an-open-label-trial
#5
Yuichi Esaki, Tsuyoshi Kitajima, Yasuhiro Ito, Shigefumi Koike, Yasumi Nakao, Akiko Tsuchiya, Marina Hirose, Nakao Iwata
It has been recently discovered that blue wavelengths form the portion of the visible electromagnetic spectrum that most potently regulates circadian rhythm. We investigated the effect of blue light-blocking glasses in subjects with delayed sleep phase disorder (DSPD). This open-label trial was conducted over 4 consecutive weeks. The DSPD patients were instructed to wear blue light-blocking amber glasses from 21:00 p.m. to bedtime, every evening for 2 weeks. To ascertain the outcome of this intervention, we measured dim light melatonin onset (DLMO) and actigraphic sleep data at baseline and after the treatment...
2016: Chronobiology International
https://www.readbyqxmd.com/read/27110143/delayed-sleep-phase-disorder-clinical-perspective-with-a-focus-on-light-therapy
#6
REVIEW
Mariana G Figueiro
Delayed sleep phase disorder (DSPD) is common among adolescents and further increases their susceptibility to chronic sleep restriction and associated detrimental outcomes, including increased risk of depression, drug and alcohol use, behavioral problems, and poor scholastic performance. DSPD is characterized by sleep onset that occurs significantly later than desired bedtimes and societal norms. Individuals with DSPD exhibit long sleep latencies when attempting to sleep at conventional bedtimes. Circadian sleep disorders such as DSPD can occur when there is misalignment between sleep timing and societal norms...
2016: Nature and Science of Sleep
https://www.readbyqxmd.com/read/26847016/home-dim-light-melatonin-onsets-with-measures-of-compliance-in-delayed-sleep-phase-disorder
#7
Helen J Burgess, Margaret Park, James K Wyatt, Louis F Fogg
The dim light melatonin onset (DLMO) assists with the diagnosis and treatment of circadian rhythm sleep disorders. Home DLMOs are attractive for cost savings and convenience, but can be confounded by home lighting and sample timing errors. We developed a home saliva collection kit with objective measures of light exposure and sample timing. We report on our first test of the kit in a clinical population. Thirty-two participants with delayed sleep phase disorder (DSPD; 17 women, aged 18-52 years) participated in two back-to-back home and laboratory phase assessments...
June 2016: Journal of Sleep Research
https://www.readbyqxmd.com/read/26434674/the-etiology-of-delayed-sleep-phase-disorder
#8
REVIEW
Gorica Micic, Nicole Lovato, Michael Gradisar, Sally A Ferguson, Helen J Burgess, Leon C Lack
According to classification manuals for sleep disorders, nine disorders are directly related to biological clock timing misalignments. Of all, delayed sleep phase disorder (DSPD) is the most commonly diagnosed, predominantly affecting adolescents, young adults, and insomnia patients. It is a persistent inability to fall asleep at earlier, more desirable and socially conventional times, coupled with extreme difficulty awakening in the morning. Considerable evidence shows a delay in the circadian clock to be associated with DSPD...
June 2016: Sleep Medicine Reviews
https://www.readbyqxmd.com/read/26244417/cognitive-behavioral-therapy-as-an-adjunct-treatment-to-light-therapy-for-delayed-sleep-phase-disorder-in-young-adults-a-randomized-controlled-feasibility-study
#9
RANDOMIZED CONTROLLED TRIAL
Katarina Danielsson, Markus Jansson-Fröjmark, Jan-Erik Broman, Agneta Markström
Delayed sleep phase disorder (DSPD) is common among young people, but there is still no evidence-based treatment available. In the present study, the feasibility of cognitive behavioral therapy (CBT) was evaluated as an additive treatment to light therapy (LT) in DSPD. A randomized controlled trial with participants aged 16 to 26 years received LT for two weeks followed by either four weeks of CBT or no treatment (NT). LT advanced sleep-wake rhythm in both groups. Comparing LT+CBT with LT+NT, no significant group differences were observed in the primary endpoints...
2016: Behavioral Sleep Medicine
https://www.readbyqxmd.com/read/26149168/nocturnal-melatonin-profiles-in-patients-with-delayed-sleep-wake-phase-disorder-and-control-sleepers
#10
Gorica Micic, Nicole Lovato, Michael Gradisar, Helen J Burgess, Sally A Ferguson, David J Kennaway, Leon Lack
A significant delay in the timing of endogenous circadian rhythms has been associated with delayed sleep phase disorder (DSPD). More recently, other mechanisms have also been proposed to account for this disorder. To further explore the etiology of DSPD, the present study compared nocturnal melatonin profiles of 26 DSPD patients (18 males, 8 females; age, 21.73 ± 4.98 years) and 17 normally timed good sleepers (10 males, 7 females; age, 23.82 ± 5.23 years) in a time-free, dim-light (<10 lux) laboratory environment...
October 2015: Journal of Biological Rhythms
https://www.readbyqxmd.com/read/25940511/the-ticking-clock-of-cayo-santiago-macaques-and-its-implications-for-understanding-human-circadian-rhythm-disorders
#11
REVIEW
Irina V Zhdanova, Jeffrey Rogers, Janis González-Martínez, Lindsay A Farrer
The circadian clock disorders in humans remain poorly understood. However, their impact on the development and progression of major human conditions, from cancer to insomnia, metabolic or mental illness becomes increasingly apparent. Addressing human circadian disorders in animal models is, in part, complicated by inverse temporal relationship between the core clock and specific physiological or behavioral processes in diurnal and nocturnal animals. Major advantages of a macaque model for translational circadian research, as a diurnal vertebrate phylogenetically close to humans, are further emphasized by the discovery of the first familial circadian disorder in non-human primates among the rhesus monkeys originating from Cayo Santiago...
January 2016: American Journal of Primatology
https://www.readbyqxmd.com/read/25609048/an-efficient-approach-for-pixel-decomposition-to-increase-the-spatial-resolution-of-land-surface-temperature-images-from-modis-thermal-infrared-band-data
#12
Fei Wang, Zhihao Qin, Wenjuan Li, Caiying Song, Arnon Karnieli, Shuhe Zhao
Land surface temperature (LST) images retrieved from the thermal infrared (TIR) band data of Moderate Resolution Imaging Spectroradiometer (MODIS) have much lower spatial resolution than the MODIS visible and near-infrared (VNIR) band data. The coarse pixel scale of MODIS LST images (1000 m under nadir) have limited their capability in applying to many studies required high spatial resolution in comparison of the MODIS VNIR band data with pixel scale of 250-500 m. In this paper we intend to develop an efficient approach for pixel decomposition to increase the spatial resolution of MODIS LST image using the VNIR band data as assistance...
2015: Sensors
https://www.readbyqxmd.com/read/25603315/sleep-arousal-and-circadian-rhythms-in-adults-with-obsessive-compulsive-disorder-a-meta-analysis
#13
REVIEW
Jacob A Nota, Katherine M Sharkey, Meredith E Coles
Findings of this meta-analysis show that obsessive-compulsive disorder (OCD) is related to disruptions in both the duration and timing of sleep. PsycINFO and Google Scholar database searches identified 12 relevant studies that compared measures of sleep in individuals with OCD to those of either a healthy control group or published norms. Sleep measures included sleep onset latency, sleep duration, awakening after sleep onset, percentage of rapid eye movement (REM) sleep, percentage of slow wave sleep, and prevalence of delayed sleep phase disorder (DSPD)...
April 2015: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/25156750/difficult-morning-awakening-from-rapid-eye-movement-sleep-and-impaired-cognitive-function-in-delayed-sleep-phase-disorder-patients
#14
Brandy Solheim, Knut Langsrud, Håvard Kallestad, Alexander Olsen, Bjørn Bjorvatn, Trond Sand
OBJECTIVES: Difficult awakening is a key symptom of delayed sleep phase disorder (DSPD), but no studies have quantified awakening thresholds in a sleep laboratory. This study assessed whether cognitive function was impaired after awakening and whether difficult awakening was associated with specific polysomnographic features such as slow wave sleep stage N3. METHODS: Nine patients with DSPD and nine sex- and age-matched healthy controls were included. Polysomnography was performed at our university hospital from midnight...
October 2014: Sleep Medicine
https://www.readbyqxmd.com/read/25149451/a-molecular-mechanism-of-mitotic-centrosome-assembly-in-drosophila
#15
Paul T Conduit, Jennifer H Richens, Alan Wainman, James Holder, Catarina C Vicente, Metta B Pratt, Carly I Dix, Zsofia A Novak, Ian M Dobbie, Lothar Schermelleh, Jordan W Raff
Centrosomes comprise a pair of centrioles surrounded by pericentriolar material (PCM). The PCM expands dramatically as cells enter mitosis, but it is unclear how this occurs. In this study, we show that the centriole protein Asl initiates the recruitment of DSpd-2 and Cnn to mother centrioles; both proteins then assemble into co-dependent scaffold-like structures that spread outwards from the mother centriole and recruit most, if not all, other PCM components. In the absence of either DSpd-2 or Cnn, mitotic PCM assembly is diminished; in the absence of both proteins, it appears to be abolished...
2014: ELife
https://www.readbyqxmd.com/read/24927739/the-westgate-service-and-related-referral-assessment-and-treatment-processes
#16
Alice L Bennett
The formerly named "Dangerous and Severe Personality Disorder" (DSPD) units are no longer standalone services within the criminal justice system in England and Wales. These sites now provide personality disorder treatment services in the high-security prison estate as part of the new national Offender Personality Disorder (OPD) Pathway Strategy. The OPD Pathway intends to take responsibility for the assessment, treatment, and management of offenders who are likely to have a personality disorder and who present a high risk of re-offending (men and women) and serious harm to others (men)...
December 2015: International Journal of Offender Therapy and Comparative Criminology
https://www.readbyqxmd.com/read/24548144/identifying-advanced-and-delayed-sleep-phase-disorders-in-the-general-population-a-national-survey-of-new-zealand-adults
#17
COMPARATIVE STUDY
Sarah-Jane Paine, Jo Fink, Philippa H Gander, Guy R Warman
The aim was to estimate the prevalence of, and identify independent risk factors for, Advanced (ASPD) and Delayed Sleep Phase Disorder (DSPD) among Māori (indigenous New Zealanders) and non-Māori adults using a self-report questionnaire. The Munich Chronotype Questionnaire was mailed to a stratified sample of 9100 adults (5100 Māori and 4000 non-Māori) aged 20-59 years randomly selected from the electoral rolls (54% response rate). Different definitions for ASPD and DSPD were developed using combinations of symptoms including self-reported bed and rising times, current chronotype, and a desire to change sleep schedule...
June 2014: Chronobiology International
https://www.readbyqxmd.com/read/24482087/-dependence-of-nitrite-assimilation-in-green-algae-on-energy-supplied-by-respiration-and-photosynthesis
#18
A Hofmann
Inhibitors and uncouplers of phosphorylation, i.e., arsenate, 2.4-dinitrophenol (DNP), pentachlorophenol (PCP), and carbonyl cyanide m-chlorophenylhydrazone (CCCP), inhibit the assimilation of nitrite by the green alga Ankistrodesmus braunii in the dark and in the light. In a medium containing nitrate, these inhibitors interrupt nitrate reduction at the level of nitrite. In phosphatedeficient algae, the assimilation of nitrite can be decreased by a concomitant, energy-dependent uptake of chloride and phosphate ions...
March 1971: Planta
https://www.readbyqxmd.com/read/24425256/the-hydrogenase-nitrogenase-relationship-in-the-blue-green-algaanabaena-cylindrica
#19
H Bothe, J Tennigkeit, G Eisbrenner, M G Yates
Nitrogen-fixingAnabaena cylindrica cells are found to evolve hydrogen in high quantities in the presence of CO plus C2H2. Studies with the inhibitors dichlorophenyldimethylurea (DCMU), disalicylidenepropanediamine (DSPD), dibromothymoquinone (DBMIB), undecylbenzimidazole (UDB) and chloro-carbonyl-cyanide-phenylhydrazone (CCCP) and also withAnabaena grown on nitrate- and ammonia-nitrogen show that the H2-formation is due to the ATP-dependent H3O(+)-reduction catalysed by nitrogenase. In control experiments CO plus C2H2 inhibited the activities of a cell-free hydrogenase fromClostridium pasteurianum...
January 1977: Planta
https://www.readbyqxmd.com/read/24283705/the-personality-profile-of-young-adults-with-delayed-sleep-phase-disorder
#20
Ane Wilhelmsen-Langeland, Ingvild W Saxvig, Ståle Pallesen, Inger-Hilde Nordhus, Oystein Vedaa, Eli Sørensen, Bjørn Bjorvatn
Delayed sleep phase disorder (DSPD) is a circadian rhythm sleep disorder characterized by a substantial delay in the major sleep period, resulting in difficulties falling asleep and awakening at a socially desirable time in the morning. This study is the first to investigate the NEO-Personality Inventory-Revised profile of young adults with DSPD. The study includes 40 patients diagnosed with DSPD (mean age = 20.7) and 21 healthy controls (mean age = 21.1). Results showed that young adults with DSPD scored higher on Neuroticism, lower on Extroversion, and much lower on Conscientiousness than the control group...
2014: Behavioral Sleep Medicine
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