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Delayed onset sleep phase

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https://www.readbyqxmd.com/read/28621018/sleep-structure-in-blindness-is-influenced-by-circadian-desynchrony
#1
Sébrina Aubin, Poul Jennum, Tore Nielsen, Ron Kupers, Maurice Ptito
We examined the structure, duration and quality of sleep, including non-rapid eye movement sleep and rapid eye movement sleep, in 11 blind individuals without conscious light perception and 11 age- and sex-matched sighted controls. Because blindness is associated with a greater incidence of free-running circadian rhythms, we controlled for circadian phase by a measure of melatonin onset timing. When circadian rhythm was entrained and melatonin onset occurred at normal times, sleep structure did not differ between blind and sighted individuals...
June 16, 2017: Journal of Sleep Research
https://www.readbyqxmd.com/read/28607474/irregular-sleep-wake-patterns-are-associated-with-poorer-academic-performance-and-delayed-circadian-and-sleep-wake-timing
#2
Andrew J K Phillips, William M Clerx, Conor S O'Brien, Akane Sano, Laura K Barger, Rosalind W Picard, Steven W Lockley, Elizabeth B Klerman, Charles A Czeisler
The association of irregular sleep schedules with circadian timing and academic performance has not been systematically examined. We studied 61 undergraduates for 30 days using sleep diaries, and quantified sleep regularity using a novel metric, the sleep regularity index (SRI). In the most and least regular quintiles, circadian phase and light exposure were assessed using salivary dim-light melatonin onset (DLMO) and wrist-worn photometry, respectively. DLMO occurred later (00:08 ± 1:54 vs. 21:32 ± 1:48; p < 0...
June 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28522096/sleep-and-circadian-variability-in-people-with-delayed-sleep-wake-phase-disorder-versus-healthy-controls
#3
Helen J Burgess, Margaret Park, James K Wyatt, Muneer Rizvydeen, Louis F Fogg
OBJECTIVE/BACKGROUND: To compare sleep and circadian variability in adults with delayed sleep-wake phase disorder (DSWPD) to healthy controls. PATIENTS/METHODS: Forty participants (22 DSWPD, 18 healthy controls) completed a ten-day protocol, consisting of DLMO assessments on two consecutive nights, a five-day study break, followed by two more DLMO assessments. All participants were instructed to sleep within one hour of their self-reported average sleep schedule for the last four days of the study break...
June 2017: Sleep Medicine
https://www.readbyqxmd.com/read/28522084/circadian-phase-dynamics-of-subjective-sleepiness-and-sensitivity-to-blue-light-in-young-adults-complaining-of-a-delayed-sleep-schedule
#4
Christophe Moderie, Solenne Van der Maren, Marie Dumont
OBJECTIVE: To assess factors that might contribute to a delayed sleep schedule in young adults with sub-clinical features of delayed sleep phase disorder. METHODS: Two groups of 14 young adults (eight women) were compared: one group complaining of a delayed sleep schedule and a control group with an earlier bedtime and no complaint. For one week, each subject maintained a target bedtime reflecting their habitual sleep schedule. Subjects were then admitted to the laboratory for the assessment of circadian phase (dim light melatonin onset), subjective sleepiness, and non-visual light sensitivity...
June 2017: Sleep Medicine
https://www.readbyqxmd.com/read/28470767/sleep-wake-rhythm-disturbances-and-perceived-sleep-in-adolescent-chronic-fatigue-syndrome
#5
Maria Pedersen, Mirjam Ekstedt, Milada C Småstuen, Vegard B Wyller, Dag Sulheim, Even Fagermoen, Anette Winger, Edvard Pedersen, Harald Hrubos-Strøm
Chronic fatigue syndrome (CFS) is characterized by long-lasting, disabling and unexplained fatigue that is often accompanied by unrefreshing sleep. The aim of this cross-sectional study was to investigate sleep-wake rhythm and perceived sleep in adolescent CFS patients compared to healthy individuals. We analysed baseline data on 120 adolescent CFS patients and 39 healthy individuals included in the NorCAPITAL project. Activity measures from a uniaxial accelerometer (activPAL) were used to estimate mid-sleep time (mid-point of a period with sleep) and time in bed...
May 4, 2017: Journal of Sleep Research
https://www.readbyqxmd.com/read/28442311/sleep-phase-delay-in-cystic-fibrosis-a-potential-new-manifestation-of-cystic-fibrosis-transmembrane-regulator-dysfunction
#6
Judy L Jensen, Christopher R Jones, Christiana Kartsonaki, Kristyn A Packer, Frederick R Adler, Theodore G Liou
BACKGROUND: Cystic fibrosis (CF) transmembrane regulator (CFTR) protein dysfunction causes CF. Improving survival allows detection of increasingly subtle disease manifestations. CFTR dysfunction in the central nervous system (CNS) may disturb circadian rhythm and thus sleep phase. We studied sleep in adults to better understand potential CNS CFTR dysfunction. METHODS: We recruited participants from April 2012 through April 2015 and administered the Munich Chronotype Questionnaire (MCTQ)...
April 22, 2017: Chest
https://www.readbyqxmd.com/read/28440811/evaluation-of-circadian-phenotypes-utilizing-fibroblasts-from-patients-with-circadian-rhythm-sleep-disorders
#7
A Hida, Y Ohsawa, S Kitamura, K Nakazaki, N Ayabe, Y Motomura, K Matsui, M Kobayashi, A Usui, Y Inoue, H Kusanagi, Y Kamei, K Mishima
We evaluated the circadian phenotypes of patients with delayed sleep-wake phase disorder (DSWPD) and non-24-hour sleep-wake rhythm disorder (N24SWD), two different circadian rhythm sleep disorders (CRSDs) by measuring clock gene expression rhythms in fibroblast cells derived from individual patients. Bmal1-luciferase (Bmal1-luc) expression rhythms were measured in the primary fibroblast cells derived from skin biopsy samples of patients with DSWPD and N24SWD, as well as control subjects. The period length of the Bmal1-luc rhythm (in vitro period) was distributed normally and was 22...
April 25, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/28424614/relationship-between-cognitive-and-sleep-wake-variables-in-asymptomatic-offspring-of-patients-with-late-onset-alzheimer-s-disease
#8
Carolina Abulafia, Bárbara Duarte-Abritta, Mirta F Villarreal, María S Ladrón-de-Guevara, Celeste García, Geraldine Sequeyra, Gustavo Sevlever, Leticia Fiorentini, Karl-Jürgen Bär, Deborah R Gustafson, Daniel E Vigo, Salvador M Guinjoan
Early neuropathological changes characteristic of late-onset Alzheimer's disease (LOAD) involve brain stem and limbic structures that regulate neurovegetative functions, including sleep-wake rhythm. Indeed, sleep pattern is an emerging biomarker and a potential pathophysiological mechanism in LOAD. We hypothesized that cognitively asymptomatic, middle-aged offspring of patients with LOAD (O-LOAD) would display a series of circadian rhythm abnormalities prior to the onset of objective cognitive alterations. We tested 31 children of patients with LOAD (O-LOAD) and 19 healthy individuals without family history of Alzheimer's disease (control subjects, CS) with basic tests of cognitive function, as well as actigraphy measures of sleep-wake rhythm, cardiac autonomic function, and bodily temperature...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/28367676/are-individual-differences-in-sleep-and-circadian-timing-amplified-by-use-of-artificial-light-sources
#9
Krithika Swaminathan, Elizabeth B Klerman, Andrew J K Phillips
Within the human population, there is large interindividual variability in the timing of sleep and circadian rhythms. This variability has been attributed to individual differences in sleep physiology, circadian physiology, and/or light exposure. Recent experimental evidence suggests that the latter is necessary to evoke large interindividual differences in sleep and circadian timing. We used a validated model of human sleep and circadian physiology to test the hypothesis that intrinsic differences in sleep and circadian timing are amplified by self-selected use of artificial light sources...
April 2017: Journal of Biological Rhythms
https://www.readbyqxmd.com/read/28364473/prevalence-of-circadian-misalignment-and-its-association-with-depressive-symptoms-in-delayed-sleep-phase-disorder
#10
Jade M Murray, Tracey L Sletten, Michelle Magee, Christopher Gordon, Nicole Lovato, Delwyn J Bartlett, David J Kennaway, Leon C Lack, Ronald R Grunstein, Steven W Lockley, Shantha M W Rajaratnam
Study Objective: To examine the prevalence of circadian misalignment in clinically diagnosed delayed sleep phase disorder (DSPD) and to compare mood and daytime functioning in those with and without a circadian basis for the disorder. Methods: One hundred and eighty-two DSPD patients aged 16-64 years, engaged in regular employment or school, underwent sleep-wake monitoring in the home, followed by a sleep laboratory visit for assessment of salivary dim light melatonin onset (DLMO)...
January 1, 2017: Sleep
https://www.readbyqxmd.com/read/28327443/correcting-delayed-circadian-phase-with-bright-light-therapy-predicts-improvement-in-adhd-symptoms-a-pilot-study
#11
Rachel E Fargason, Aaron D Fobian, Lauren M Hablitz, Jodi R Paul, Brittny A White, Karen L Cropsey, Karen L Gamble
Attention-deficit/hyperactivity disorder (ADHD) is a common condition with comorbid insomnia reported in >70% of children and adults. These patients demonstrate delays in sleep-wake rhythms, nocturnal rise in melatonin, and early morning rise in cortisol. Given that standard psychopharmacologic treatments for ADHD often do not completely control symptoms in participants with circadian rhythm delay, we sought to test whether bright light therapy (BLT) advances circadian rhythms and further reduces ADHD symptoms over standard treatments...
March 6, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/28321642/circadian-rhythm-dysregulation-in-bipolar-spectrum-disorders
#12
REVIEW
Lauren B Alloy, Tommy H Ng, Madison K Titone, Elaine M Boland
PURPOSE OF REVIEW: We review recent evidence for circadian rhythm dysregulation in bipolar spectrum disorders (BSDs). We examine evidence for endogenous abnormalities in the biological clock and disruptions in the external entrainment of circadian rhythms in BSDs. We also address whether circadian dysregulation provides vulnerability to onset of BSD and evidence for a new integration of reward and circadian dysregulation in BSD. RECENT FINDINGS: Relative circadian phase delay (e...
April 2017: Current Psychiatry Reports
https://www.readbyqxmd.com/read/28285255/relationships-between-circadian-measures-depression-and-response-to-antidepressant-treatment-a-preliminary-investigation
#13
Leslie M Swanson, Helen J Burgess, Edward D Huntley, Holli Bertram, Ann Mooney, Jennifer Zollars, Richard Dopp, Robert Hoffmann, Roseanne Armitage, J Todd Arnedt
Few studies have examined relationships between circadian rhythms and unipolar major depressive disorder. Further, no study to date has examined circadian markers as predictors of response to depression treatment. In the present study, we examined associations between circadian timing and its alignment with sleep and depression severity in 30 adults with major depressive disorder who completed a randomized controlled trial of two weeks of time in bed (TIB) restriction administered adjunctive to fluoxetine, with a focus on sex differences...
June 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28064405/a-systematic-review-of-circadian-function-chronotype-and-chronotherapy-in-attention-deficit-hyperactivity-disorder
#14
REVIEW
Andrew N Coogan, Niall M McGowan
Reports of sleep disturbances in attention deficit hyperactivity disorder (ADHD) are common in both children and adults; however, the aetiology of such disturbances is poorly understood. One potentially important mechanism which may be implicated in disrupted sleep in ADHD is the circadian clock, a known key regulator of the sleep/wake cycle. In this systematic review, we analyse the evidence for circadian rhythm changes associated with ADHD, as well as assessing evidence for therapeutic approaches involving the circadian clock in ADHD...
January 7, 2017: Attention Deficit and Hyperactivity Disorders
https://www.readbyqxmd.com/read/28042611/bedtime-and-evening-light-exposure-influence-circadian-timing-in-preschool-age-children-a-field-study
#15
Lameese D Akacem, Kenneth P Wright, Monique K LeBourgeois
Light exposure and sleep timing are two factors that influence inter-individual variability in the timing of the human circadian clock. The aim of this study was to quantify the degree to which evening light exposure predicts variance in circadian timing over and above bedtime alone in preschool children. Participants were 21 children ages 4.5-5.0 years (4.7 ± 0.2 years; 9 females). Children followed their typical sleep schedules for 4 days during which time they wore a wrist actigraph to assess sleep timing and a pendant light meter to measure minute-by-minute illuminance levels in lux...
November 2016: Neurobiology of Sleep and Circadian Rhythms
https://www.readbyqxmd.com/read/27990327/circadian-based-therapies-for-circadian-rhythm-sleep-wake-disorders
#16
Helen J Burgess, Jonathan S Emens
This review summarizes recent developments relevant to the treatment of circadian rhythm sleep-wake disorders. The clinical practice guidelines for the treatment of intrinsic circadian rhythm sleep-wake disorders is described, followed by recent treatment studies for delayed sleep-wake phase disorder, non-24 hour sleep-wake disorder, irregular sleep-wake disorder and shift work. New methods to estimate circadian phase, including home saliva collection to estimate the dim light melatonin onset, circadian questionnaires and general rules to guide light and exogenous melatonin treatments are described...
September 2016: Current Sleep Medicine Reports
https://www.readbyqxmd.com/read/27912863/circadian-rhythm-and-sleep-during-prolonged-antarctic-residence-at-chinese-zhongshan-station
#17
Nan Chen, Quan Wu, Yanlei Xiong, Guang Chen, Dandan Song, Chengli Xu
OBJECTIVE: Residence at Zhongshan Station (69°22'24″S, 76°22'40″E) for over 1 year exposes winter-over members to marked changes of light-dark cycle, ranging from the constant daylight of polar days to the constant darkness of polar nights, in addition to geographic and social isolation. This extreme photoperiodic environment may increase the risk of sleep disturbances and circadian desynchrony. The aim of this study was to investigate the circadian rhythm and sleep phase of Chinese winter-over expeditioners at Zhongshan Station...
December 2016: Wilderness & Environmental Medicine
https://www.readbyqxmd.com/read/27887821/-sleep-disorders-in-internet-addiction
#18
REVIEW
Aymeric Petit, Laurent Karila, Candice Estellat, Delphine Moisan, Michel Reynaud, Marie-Pia D'Ortho, Michel Lejoyeux, Fanny Levy
BACKGROUND: The relationship between sleep disorders and Internet addiction has been little work. Given the importance of these disorders, we felt it appropriate to make a synthesis of available data and to establish causality or accountability between Internet addiction and the onset of sleep disorders. METHODS: A literature review was then performed. We selected scientific articles in English and French, published between 1987 and 2016 by consulting the databases Medline, Embase, PsycINFO and Google Scholar...
December 2016: La Presse Médicale
https://www.readbyqxmd.com/read/27868260/an-experimental-study-of-adolescent-sleep-restriction-during-a-simulated-school-week-changes-in-phase-sleep-staging-performance-and-sleepiness
#19
Alex Agostini, Mary A Carskadon, Jillian Dorrian, Scott Coussens, Michelle A Short
This laboratory study investigated the impact of restricted sleep during a simulated school week on circadian phase, sleep stages and daytime functioning. Changes were examined across and within days and during a simulated weekend recovery. Participants were 12 healthy secondary school students (six male) aged 15-17 years [mean = 16.1 years, standard deviation (SD) = 0.9]. After 2 nights with 10 h (21:30-07:30 hours), time in bed was restricted to 5 h for 5 nights (02:30-07:30 hours), then returned to 10 h time in bed for 2 nights (21:30-07:30 hours)...
November 21, 2016: Journal of Sleep Research
https://www.readbyqxmd.com/read/27754700/effect-of-aptensio-xr-methylphenidate-hcl-extended-release-capsules-on-sleep-in-children-with-attention-deficit-hyperactivity-disorder
#20
Judith Owens, Margaret Weiss, Earl Nordbrock, Greg Mattingly, Sharon Wigal, Laurence L Greenhill, Wei-Wei Chang, Ann Childress, Robert J Kupper, Akwete Adjei
OBJECTIVE: To evaluate measures of sleep (exploratory endpoints) in two pivotal studies of a multilayer bead extended-release methylphenidate (MPH-MLR) treatment of attention-deficit/hyperactivity disorder in children. METHODS: Study 1 evaluated the time course of response to MPH-MLR (n = 26) patients in an analog classroom setting through four phases: screening (≤28 days), open label (OL) dose optimization (4 weeks), double-blind (DB) crossover (2 weeks; placebo vs...
December 2016: Journal of Child and Adolescent Psychopharmacology
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