keyword
MENU ▼
Read by QxMD icon Read
search

Ambition

keyword
https://www.readbyqxmd.com/read/28930330/chemistry-and-engineering-of-cyclodextrins-for-molecular-imaging
#1
REVIEW
Wing-Fu Lai, Andrey L Rogach, Wing-Tak Wong
Cyclodextrins (CDs) are naturally occurring cyclic oligosaccharides bearing a basket-shaped topology with an "inner-outer" amphiphilic character. The abundance of hydroxyl groups enables CDs to be functionalized with multiple targeting ligands and imaging elements. The imaging time, and the payload of different imaging elements, can be tuned by taking advantage of the commercial availability of CDs with different sizes of the cavity. This review aims to offer an outlook of the chemistry and engineering of CDs for the development of molecular probes...
September 20, 2017: Chemical Society Reviews
https://www.readbyqxmd.com/read/28928261/paris-agreement-s-ambition-to-limit-global-warming-to-1-5%C3%A2-c-still-possible-analysis-shows
#2
Ingrid Torjesen
No abstract text is available yet for this article.
September 19, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28926414/exploration-of-quantitative-sensory-testing-in-latent-trigger-points-and-referred-pain-areas
#3
Silvia Ambite-Quesada, José L Arías-Buría, Carol A Courtney, Lars Arendt-Nielsen, César Fernández-de-Las-Peñas
OBJECTIVE: To investigate somato-sensory nerve fibre function by applying different quantitative sensory testing including thermal, mechanical and vibration thresholds over latent trigger points (TrP) and in its associated referred pain area. METHODS: A total of 20 subjects with unilateral latent TrPs in the extensor carpi radialis brevis were included. Warmth detection threshold (WDT), cold detection threshold CDT) and heat/cold pain thresholds (HPT, CPT), mechanical detection (MDT) and pain (MPT) thresholds, vibration threshold (VT), and pressure pain thresholds (PPT) were blinded assessed over the TrP, in the referred pain area, and in the respective contra-lateral mirror areas...
September 15, 2017: Clinical Journal of Pain
https://www.readbyqxmd.com/read/28916366/measuring-progress-and-projecting-attainment-on-the-basis-of-past-trends-of-the-health-related-sustainable-development-goals-in-188-countries-an-analysis-from-the-global-burden-of-disease-study-2016
#4
(no author information available yet)
BACKGROUND: The UN's Sustainable Development Goals (SDGs) are grounded in the global ambition of "leaving no one behind". Understanding today's gains and gaps for the health-related SDGs is essential for decision makers as they aim to improve the health of populations. As part of the Global Burden of Diseases, Injuries, and Risk Factors Study 2016 (GBD 2016), we measured 37 of the 50 health-related SDG indicators over the period 1990-2016 for 188 countries, and then on the basis of these past trends, we projected indicators to 2030...
September 8, 2017: Lancet
https://www.readbyqxmd.com/read/28914395/repetitive-on-demand-drug-release-from-polymeric-matrices-containing-a-macroscopic-spherical-iron-core
#5
Stefan A Rovers, Maartje F Kemmere, Jos T F Keurentjes, Richard Hoogenboom
A system for multiple on-demand drug release has been prepared that can be activated with an alternating magnetic field as external trigger. The core/shell samples have been developed based on a macroscopic spherical iron core coated with a thermoresponsive polymer, poly(styrene-stat-butyl methacrylate), containing ibuprofen as a model drug. During exposure of the samples to the magnetic field (ON state), the release rate of ibuprofen is significantly increased, up to 35 times the release rate without the magnetic field (OFF state)...
September 15, 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/28904449/james-wenceslaus-papez-his-circuit-and-emotion
#6
Kalyan B Bhattacharyya
James Papez worked on the anatomical substrates of emotion and described a circuit, mainly composed of the hippocampus, thalamus and cingulum, and published his observations in 1937. However, such an idea existed before him, as evidenced by the rudimentary indications from Paul Broca, and Paul MacLean added some other structures like, septum, amygdala, and hypothalamus in its ambit and called it the limbic system. Paul Ivan Yakovlev, proposed a circuit which also referred to orbitofrontal, insular, anterior temporal lobe, and other nuclei of thalamus...
July 2017: Annals of Indian Academy of Neurology
https://www.readbyqxmd.com/read/28895138/feed-backs-among-inbreeding-inbreeding-depression-in-sperm-traits-and-sperm-competition-can-drive-evolution-of-costly-polyandry
#7
Greta Bocedi, Jane M Reid
Ongoing ambitions are to understand the evolution of costly polyandry and its consequences for species ecology and evolution. Emerging patterns could stem from feed-back dynamics between the evolving mating system and its genetic environment, defined by interactions among kin including inbreeding. However, such feed-backs are rarely considered in non-selfing systems. We use a genetically-explicit model to demonstrate a mechanism by which inbreeding depression can select for polyandry to mitigate the negative consequences of mating with inbred males rather than avoiding inbreeding...
September 12, 2017: Evolution; International Journal of Organic Evolution
https://www.readbyqxmd.com/read/28894686/risk-factors-for-delirium-after-spine-surgery-in-extremely-elderly-patients-aged-80-years-or-older-and-review-of-the-literature-japan-association-of-spine-surgeons-with-ambition-multicenter-study
#8
Kazuyoshi Kobayashi, Shiro Imagama, Kei Ando, Naoki Ishiguro, Masaomi Yamashita, Yawara Eguchi, Morio Matsumoto, Ken Ishii, Tomohiro Hikata, Shoji Seki, Hidetomi Terai, Akinobu Suzuki, Koji Tamai, Masaaki Aramomi, Tetsuhiro Ishikawa, Atsushi Kimura, Hirokazu Inoue, Gen Inoue, Masayuki Miyagi, Wataru Saito, Kei Yamada, Michio Hongo, Yuji Matsuoka, Hidekazu Suzuki, Atsushi Nakano, Kazuyuki Watanabe, Hirotaka Chikuda, Junichi Ohya, Yasuchika Aoki, Masayuki Shimizu, Toshimasa Futatsugi, Keijiro Mukaiyama, Masaichi Hasegawa, Katsuhito Kiyasu, Haku Iizuka, Yoichi Iizuka, Ryoichi Kobayashi, Kotaro Nishida, Kenichiro Kakutani, Hideaki Nakajima, Hideki Murakami, Satoru Demura, Satoshi Kato, Katsuhito Yoshioka, Takashi Namikawa, Kei Watanabe, Kazuyoshi Nakanishi, Yukihiro Nakagawa, Mitsunori Yoshimoto, Hiroyasu Fujiwara, Norihiro Nishida, Yasuaki Imajo, Masashi Yamazaki, Masataka Sakane, Tetsuya Abe, Kengo Fujii, Takashi Kaito, Takeo Furuya, Sumihisa Orita, Seiji Ohtori
STUDY DESIGN: Retrospective database analysis. OBJECTIVE: Spine surgeries in elderly patients have increased in recent years due to aging of society and recent advances in surgical techniques, and postoperative complications have become more of a concern. Postoperative delirium is a common complication in elderly patients that impairs recovery and increases morbidity and mortality. The objective of the study was to analyze postoperative delirium associated with spine surgery in patients aged 80 years or older with cervical, thoracic, and lumbar lesions...
September 2017: Global Spine Journal
https://www.readbyqxmd.com/read/28894480/patient-participation-in-ers-guidelines-and-research-projects-the-embarc-experience
#9
REVIEW
James D Chalmers, Alan Timothy, Eva Polverino, Marta Almagro, Thomas Ruddy, Pippa Powell, Jeanette Boyd
The European Multicentre Bronchiectasis Audit and Research Collaboration (EMBARC) is a European Respiratory Society (ERS) Clinical Research Collaboration dedicated to improving research and clinical care for people with bronchiectasis. EMBARC has created a European Bronchiectasis Registry, funded by the ERS and by the European Union (EU) Innovative Medicines Initiative Programme. From the outset, EMBARC had the ambition to be a patient-focussed project. In contrast to many respiratory diseases, however, there are no specific patient charities or European patient organisations for patients with bronchiectasis and no existing infrastructure for patient engagement...
September 2017: Breathe
https://www.readbyqxmd.com/read/28890455/internationalism-and-engineering-in-unesco-during-the-end-game-of-empire-1943-68
#10
Casper Andersen
When UNESCO was founded in 1945 the organization aimed to become a pivotal player in international collaboration in the field of engineering. UNESCO based its engineering initiatives on the World Engineering Conference, an organization espousing a politically motivated "technocratic internationalism" and on the World Power Conference, an organization promoting a business-friendly stance of "engineering internationalism." These competing models for international collaboration curtailed UNESCO's institutional ambitions...
2017: Technology and Culture
https://www.readbyqxmd.com/read/28888287/the-optimism-trap-migrants-educational-choices-in-stratified-education-systems
#11
Jasper Dag Tjaden, Christian Hunkler
Immigrant children's ambitious educational choices have often been linked to their families' high level of optimism and motivation for upward mobility. However, previous research has mostly neglected alternative explanations such as information asymmetries or anticipated discrimination. Moreover, immigrant children's higher dropout rates at the higher secondary and university level suggest that low performing migrant students could have benefitted more from pursuing less ambitious tracks, especially in countries that offer viable vocational alternatives...
September 2017: Social Science Research
https://www.readbyqxmd.com/read/28880921/urinary-proteomics-in-predicting-heart-transplantation-outcomes-uprophet-rationale-and-database-description
#12
Qi-Fang Huang, Sander Trenson, Zhen-Yu Zhang, Wen-Yi Yang, Lucas Van Aelst, Esther Nkuipou-Kenfack, Fang-Fei Wei, Blerim Mujaj, Lutgarde Thijs, Agnieszka Ciarka, Jerome Zoidakis, Walter Droogné, Antonia Vlahou, Stefan Janssens, Johan Vanhaecke, Johan Van Cleemput, Jan A Staessen
OBJECTIVES: Urinary Proteomics in Predicting Heart Transplantation Outcomes (uPROPHET; NCT03152422) aims: (i) to construct new multidimensional urinary proteomic (UP) classifiers that after heart transplantation (HTx) help in detecting graft vasculopathy, monitoring immune system activity and graft performance, and in adjusting immunosuppression; (ii) to sequence UP peptide fragments and to identify key proteins mediating HTx-related complications; (iii) to validate UP classifiers by demonstrating analogy between UP profiles and tissue proteomic signatures (TP) in diseased explanted hearts, to be compared with normal donor hearts; (iv) and to identify new drug targets...
2017: PloS One
https://www.readbyqxmd.com/read/28876269/info-gap-robustness-pathway-method-for-transitioning-of-urban-drainage-systems-under-deep-uncertainties
#13
Jonatan Zischg, Mariana L R Goncalves, Taneha Kuzniecow Bacchin, Günther Leonhardt, Maria Viklander, Arjan van Timmeren, Wolfgang Rauch, Robert Sitzenfrei
In the urban water cycle, there are different ways of handling stormwater runoff. Traditional systems mainly rely on underground piped, sometimes named 'gray' infrastructure. New and so-called 'green/blue' ambitions aim for treating and conveying the runoff at the surface. Such concepts are mainly based on ground infiltration and temporal storage. In this work a methodology to create and compare different planning alternatives for stormwater handling on their pathways to a desired system state is presented...
September 2017: Water Science and Technology: a Journal of the International Association on Water Pollution Research
https://www.readbyqxmd.com/read/28875992/fluorescence-nanoscopy-in-cell-biology
#14
REVIEW
Steffen J Sahl, Stefan W Hell, Stefan Jakobs
Fluorescence nanoscopy uniquely combines minimally invasive optical access to the internal nanoscale structure and dynamics of cells and tissues with molecular detection specificity. While the basic physical principles of 'super-resolution' imaging were discovered in the 1990s, with initial experimental demonstrations following in 2000, the broad application of super-resolution imaging to address cell-biological questions has only more recently emerged. Nanoscopy approaches have begun to facilitate discoveries in cell biology and to add new knowledge...
September 6, 2017: Nature Reviews. Molecular Cell Biology
https://www.readbyqxmd.com/read/28855950/sea-urchin-growth-dynamics-at-microstructural-length-scale-revealed-by-mn-labeling-and-cathodoluminescence-imaging
#15
Przemysław Gorzelak, Aurélie Dery, Philippe Dubois, Jarosław Stolarski
BACKGROUND: Fluorochrome staining is among the most widely used techniques to study growth dynamics of echinoderms. However, it fails to detect fine-scale increments because produced marks are commonly diffusely distributed within the skeleton. In this paper we investigated the potential of trace element (manganese) labeling and subsequent cathodoluminescence (CL) imaging in fine-scale growth studies of echinoderms. RESULTS: Three species of sea urchins (Paracentrotus lividus, Echinometra sp...
2017: Frontiers in Zoology
https://www.readbyqxmd.com/read/28853323/-the-individual-at-the-centre-a-grounded-theory-explaining-how-sport-clubs-retain-young-adults
#16
Eva-Carin Lindgren, Claes Annerstedt, John Dohsten
PURPOSE: There is still a lack of knowledge regarding which social processes occur in sport clubs and what factors influence young adults to want to remain in a sport club context. Thus, the purpose of this study was to construct a grounded theory (GT) explaining how sport clubs can retain their young adults. METHOD: The study uses an intersectional approach. In line with constructivist GT methodology, data from 14 focus-group interviews (27 coaches and 28 young adults) were collected and analysed using a constant comparative method...
December 2017: International Journal of Qualitative Studies on Health and Well-being
https://www.readbyqxmd.com/read/28838300/supporting-global-health-goals-with-information-and-communications-technology
#17
Magnus Boman, Erik Kruse
The objective of this study is to critically assess the possible roles of information and communications technology (ICT) in supporting global health goals. This is done by considering privilege and connectibility. In short, ICT can contribute by providing health information via four different kinds of access, each with its own history and prospective future. All four are analyzed here, in two perspectives: business-as-usual and disruptive. Health data analytics is difficult since the digital representation of past, current, and future health information is lacking...
June 2017: Global Health Action
https://www.readbyqxmd.com/read/28837315/diketopyrrolopyrrole-based-photosensitizers-conjugated-with-chemotherapeutic-agents-for-multimodal-tumor-therapy
#18
Yu Cai, Pingping Liang, Qianyun Tang, Weili Si, Peng Chen, Qi Zhang, Xiaochen Dong
For synergistic cancer therapy, it is highly desirable to devise a single multifunctional agent to combine photodynamic therapy (PDT), photothermal therapy (PTT), and chemotherapy, which is soluble and excitable at low irradiation, as well as able to selectively target tumors and achieve high efficacy. Toward this ambition, here the chemotherapy drugs chlorambucil (Cb), and all trans retinoic acid (ATRA) are covalently conjugated onto a small dye molecule diketopyrrolopyrrole (DPP-Cb and DPP-ATRA). The soluble nanoparticles (NPs) of DPP-Cb and DPP-ATRA formed by reprecipitation can selectively accumulate in tumors, release chemotherapy drugs under acidic conditions, and exhibit efficient reactive oxygen species (ROS) generation and photothermal conversion under the irradiation of a low power xenon lamp (40 mW/cm(2))...
September 13, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28831421/parenting-and-female-dermatologists-perceptions-of-work-life-balance
#19
S Mattessich, K Shea, D Whitaker-Worth
BACKGROUND: Women in medicine may feel pressure to choose between the competing demands of career goals and being a dedicated spouse and parent. OBJECTIVE: The purpose of this survey study is to report on the current opinions of female dermatologists with regard to family planning, maternity leave, and career success. METHODS: We surveyed 183 members of the Women's Dermatologic Society using a 13-question survey that was approved for distribution by the institutional review board committee of the University of Connecticut Health Center...
September 2017: International Journal of Women's Dermatology
https://www.readbyqxmd.com/read/28829298/pathways-for-theoretical-advances-in-visualization
#20
Min Chen, Georges Grinstein, Chris R Johnson, Jessie Kennedy, Melanie Tory
There is little doubt that having a theoretic foundation will benefit the field of visualization, including its main subfields. Because there has been a substantial amount of work on taxonomies and conceptual models in the visualization literature and some recent work on theoretic frameworks, such a theoretic foundation is not a foolish or impractical ambition. This article asks, "How can we build a theoretic foundation for visualization collectively as a community?" The authors envision the pathways for four different aspects of a theoretic foundation: taxonomies and ontologies, principles and guidelines, conceptual models and theoretic frameworks, and quantitative laws and theoretic systems...
2017: IEEE Computer Graphics and Applications
keyword
keyword
69153
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"