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https://www.readbyqxmd.com/read/29350255/nuclear-magnetic-resonance-and-high-performance-liquid-chromatography-techniques-for-the-characterization-of-bioactive-compounds-from-humulus-lupulus-l-hop
#1
Davide Bertelli, Virginia Brighenti, Lucia Marchetti, Anna Reik, Federica Pellati
Humulus lupulus L. (hop) represents one of the most cultivated crops, it being a key ingredient in the brewing process. Many health-related properties have been described for hop extracts, making this plant gain more interest in the field of pharmaceutical and nutraceutical research. Among the analytical tools available for the phytochemical characterization of plant extracts, quantitative nuclear magnetic resonance (qNMR) represents a new and powerful technique. In this ambit, the present study was aimed at the development of a new, simple, and efficient qNMR method for the metabolite fingerprinting of bioactive compounds in hop cones, taking advantage of the novel ERETIC 2 tool...
January 19, 2018: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/29334324/the-rite-of-passage-of-becoming-a-humanitarian-health-worker-experiences-of-retention-in-sweden
#2
Sara Albuquerque, Anneli Eriksson, Helle M Alvesson
BACKGROUND: Low retention of humanitarian workers poses constraints on humanitarian organisations' capacity to respond effectively to disasters. Research has focused on reasons for humanitarian workers leaving the sector, but little is known about the factors that can elucidate long-term commitment. OBJECTIVE: To understand what motivates and supports experienced humanitarian health workers to remain in the sector. METHODS: Semi-structured interviews were conducted with 10 experienced nurses who had been on at least three field missions with Médecins Sans Frontières Sweden...
2018: Global Health Action
https://www.readbyqxmd.com/read/29327367/the-free-healthcare-initiative-in-sierra-leone-evaluating-a-health-system-reform-2010-2015
#3
Sophie Witter, Nouria Brikci, Tim Harris, Richard Williams, Sarah Keen, Ana Mujica, Alex Jones, Alex Murray-Zmijewski, Barbara Bale, Bailah Leigh, Ade Renner
This article presents the findings of a theory-based evaluation of the Sierra Leone Free Health Care Initiative (FHCI), using mixed methods. Analytical approaches included time-series analysis of national survey data to examine mortality and morbidity trends, as well as modelling of impact using the Lives Saved Tool and expenditure trend analysis. We find that the FHCI responded to a clear need in Sierra Leone, was well designed to bring about needed changes in the health system to deliver services to the target beneficiaries, and did indeed bring funds and momentum to produce important systemic reforms...
January 12, 2018: International Journal of Health Planning and Management
https://www.readbyqxmd.com/read/29326196/young-adults-perspectives-on-living-with-kidney-failure-a-systematic-review-and-thematic-synthesis-of-qualitative-studies
#4
Phillippa K Bailey, Alexander J Hamilton, Rhian L Clissold, Carol D Inward, Fergus J Caskey, Yoav Ben-Shlomo, Amanda Owen-Smith
INTRODUCTION: Young adults fare worse than younger adolescents or older adults on a broad range of health indicators. Those with a chronic illness such as renal failure are a particularly vulnerable group, who experience poor outcomes compared with both children and older adults. Understanding how being in receipt of renal replacement therapy (RRT) affects the lives of young adults might help us to better prepare and support these individuals for and on RRT, and improve outcomes. This study aimed to synthesise research describing young adults' experiences of the psychosocial impact of kidney failure and RRT...
January 10, 2018: BMJ Open
https://www.readbyqxmd.com/read/29316424/tfiid-and-myb-share-a-therapeutic-handshake-in-aml
#5
Charles C Bell, Mark A Dawson
Selectively disrupting oncogenic transcription factors in cancer remains an elusive ambition of targeted therapeutics. In this issue of Cancer Cell, Xu et al. provide an elegant proof-of-concept study demonstrating that interaction between MYB and the general transcriptional coactivator TFIID can be specifically disrupted to mediate a therapeutic effect in AML.
January 8, 2018: Cancer Cell
https://www.readbyqxmd.com/read/29315542/making-unformulated-experience-real-through-painting-painting-and-psychoanalytic-psychotherapy-practice-as-two-ways-of-making-sense
#6
Karen M Schwartz
I contend that painting, like psychoanalytic psychotherapy, is an intersubjective process able to connect hearts and minds of painters and viewers alike, because the creative process of making a painting brings painters into more complex and more animated relationship with themselves. My own painting process is largely nonverbal. Interactions between me and my evolving artwork-in-process reveal experiences, thoughts, and feelings not yet formulated in words, and so, not available explicitly to conscious awareness until visual representation allows questions of meaning and intention to be thought about and elaborated in the usual, verbal sense...
January 5, 2018: Journal of Clinical Psychology
https://www.readbyqxmd.com/read/29303716/offline-are-china-s-global-ambitions-good-for-global-health
#7
Richard Horton
No abstract text is available yet for this article.
December 23, 2018: Lancet
https://www.readbyqxmd.com/read/29290633/sam-caam-a-concept-for-acquiring-systematic-aircraft-measurements-to-characterize-aerosol-air-masses
#8
Ralph A Kahn, Tim A Berkoff, Charles Brock, Gao Chen, Richard A Ferrare, Steven Ghan, Thomas F Hansico, Dean A Hegg, J Vanderlei Martins, Cameron S McNaughton, Daniel M Murphy, John A Ogren, Joyce E Penner, Peter Pilewskie, John H Seinfeld, Douglas R Worsnop
A modest operational program of systematic aircraft measurements can resolve key satellite-aerosol-data-record limitations. Satellite observations provide frequent, global aerosol-amount maps, but offer only loose aerosol property constraints needed for climate and air quality applications. We define and illustrate the feasibility of flying an aircraft payload to measure key aerosol optical, microphysical, and chemical properties in situ. The flight program could characterize major aerosol air-mass types statistically, at a level-of-detail unobtainable from space...
October 2017: Bulletin of the American Meteorological Society
https://www.readbyqxmd.com/read/29282050/changes-in-professionals-beliefs-following-a-palliative-care-implementation-programme-at-a-surgical-department-a-qualitative-evaluation
#9
Pia Hahne, Staffan Lundström, Helena Leveälahti, Janet Winnhed, Joakim Öhlén
BACKGROUND: One ambition regarding palliative care is that it should be more accessible to patients and families regardless of care setting. Previous studies show many difficulties and shortcomings in the care of patients with palliative care needs in acute care facilities, but also challenges regarding efforts to implement palliative care. The aim of this study is to evaluate how the implementation of palliative care, using a combination of integration and consultation strategies, can change beliefs regarding palliative care among professionals in a surgical department...
December 28, 2017: BMC Palliative Care
https://www.readbyqxmd.com/read/29243555/philanthropy-and-the-nation-state-in-global-health-the-gates-foundation-in-india
#10
Manjari Mahajan
In recent years, philanthropic actors such as the Gates Foundation have been understood as commanding sweeping influence in global health. They have been associated with the outsourcing of public health services, shifting of policy priorities, and the eventual sidelining of national governments. This article makes a different argument about the impact of global philanthropic actors. It focuses on the work of the Gates Foundation in India over the last decade and a half, tracing how the foundation initially circumvented the national government but then moved on to a discourse of partnership...
December 15, 2017: Global Public Health
https://www.readbyqxmd.com/read/29232465/new-treatments-in-ovarian-cancer
#11
E Pujade-Lauraine
In targeting DNA repair pathways of the most genomic instable cancer, poly-(adenosine diphosphate [ADP])-ribose polymerase inhibitors (PARPi) have been demonstrated as the most effective drug since platinum in high grade serous or endometrioid ovarian cancer. Immunotherapy is strongly pushing the door of ovarian cancer and has the ambition to change the fate of this deadly disease when combined with chemotherapy, vascular endothelial growth factor inhibitor or PARPi. The activity of PARPi could also be improved by modulators of the cell cycle, which are required to give time enough for DNA repair...
November 1, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/29225390/immigrant-bilingualism-in-spain-an-asset-or-a-liability
#12
Maria Medvedeva, Alejandro Portes
This study contributes to the ongoing debate about bilingual advantage and examines whether bilingual immigrant youths fare better, as well as, or worse academically than the matching group of monolinguals. Using data from Spain, where close to half of immigrants speak Spanish as their native language, we found no evidence of costs of bilingualism: bilingual youths did benefit from their linguistic skills. Their advantage, however, manifested itself not uniformly across discrete outcomes, but in a direct trajectory toward higher educational attainment...
2017: International Migration Review
https://www.readbyqxmd.com/read/29218890/democratizing-data-science-through-data-science-training
#13
John Darrell Van Horn, Lily Fierro, Jeana Kamdar, Jonathan Gordon, Crystal Stewart, Avnish Bhattrai, Sumiko Abe, Xiaoxiao Lei, Caroline O'Driscoll, Aakanchha Sinha, Priyambada Jain, Gully Burns, Kristina Lerman, José Luis Ambite
The biomedical sciences have experienced an explosion of data which promises to overwhelm many current practitioners. Without easy access to data science training resources, biomedical researchers may find themselves unable to wrangle their own datasets. In 2014, to address the challenges posed such a data onslaught, the National Institutes of Health (NIH) launched the Big Data to Knowledge (BD2K) initiative. To this end, the BD2K Training Coordinating Center (TCC; bigdatau.org) was funded to facilitate both in-person and online learning, and open up the concepts of data science to the widest possible audience...
2018: Pacific Symposium on Biocomputing
https://www.readbyqxmd.com/read/29214123/pay-for-performance-motivation-to-succeed-in-advanced-trauma-life-support-courses-a-question-of-background-or-funding
#14
Roman Klein, Wolfgang Armbruster, Martin Grotz, Bernd Höner, Matthias Münzberg, Paul Alfred Grützner, Christoph Georg Wölfl
Objective: To correlate students' performance with their professional background and motivation to take part in Advanced Trauma Life Support (ATLS) courses. We base our analysis on the self-determination theory that differentiates intrinsic (ambition to perform by individual itself) from extrinsic motivation (incentive by external stimuli). Design: We present a non-blinded, monocentric, non-randomized descriptive study of 376 students taking part in an ATLS course at one course site in Germany. Part of a two-day ATLS course are two written tests; we correlate test scores with background information provided by the students in a questionnaire of 13 items (age, sex, adress, board certification, specialty, subspecialty, position, hospital level of care, hospital operator and hospital participation in trauma network, motivation, funding source, condition of funding)...
2017: GMS Interdisciplinary Plastic and Reconstructive Surgery DGPW
https://www.readbyqxmd.com/read/29198278/brain-based-biomarkers-for-the-treatment-of-depression-evolution-of-an-idea
#15
Allison C Waters, Helen S Mayberg
An ambition of depression biomarker research is to augment psychometric and cognitive assessment of clinically relevant phenomena with neural measures. Although such applications have been slow to arrive, we observe a steady evolution of the idea and anticipate emerging technologies with some optimism. To highlight critical themes and innovations in depression biomarker research, we take as our point of reference a specific research narrative. We begin with an early model of frontal-limbic dysfunction, which represents a conceptual shift from localized pathology to understanding symptoms as an emergent property of distributed networks...
October 2017: Journal of the International Neuropsychological Society: JINS
https://www.readbyqxmd.com/read/29190850/mri-cartilage-assessment-of-the-subtalar-and-midtarsal-joints-during-a-transcontinental-ultramarathon-new-insights-into-human-locomotion
#16
Uwe Hans-Werner Schütz, Christian Billich, Daniel Schoss, Meinrad Beer, Jutta Ellermann
MR measurements can be accurately performed during 4486 km of running, opening a window into in vivo assessment of hindfoot articular cartilage under extreme ultra-endurance loading. This observational cross-sectional study included 22 randomized participants of TransEurope FootRace between Italy and the North Cape, which was accompanied by a trailer-mounted 1.5T MRI scanner over 9 weeks. Four follow up MR examinations of subtalar and midtarsal joints were performed. Statistics of cartilage T2*  and thickness were obtained...
November 30, 2017: International Journal of Sports Medicine
https://www.readbyqxmd.com/read/29187756/pilot-study-on-microvascular-anastomosis-performance-and-future-educational-prospects
#17
G Berretti, G Colletti, G Parrinello, A Iavarone, P Vannucchi, A Deganello
The introduction of microvascular free flaps has revolutionised modern reconstructive surgery. Unfortunately, access to training opportunities at standardised training courses is limited and expensive. We designed a pilot study on microvascular anastomoses with the aim of verifying if a short course, easily reproducible, could transmit microvascular skills to participants; if the chosen pre-test was predictive of final performance; and if age could influence the outcome. A total of 30 participants (10 students, 10 residents and 10 surgeons) without any previous microvascular experience were instructed and tested during a single 3 to 5 hour course...
November 30, 2017: Acta Otorhinolaryngologica Italica
https://www.readbyqxmd.com/read/29180541/neonatal-brain-injuries-in-england-population-based-incidence-derived-from-routinely-recorded-clinical-data-held-in-the-national-neonatal-research-database
#18
Chris Gale, Yevgeniy Statnikov, Sena Jawad, Sabita N Uthaya, Neena Modi
OBJECTIVE: In 2015, the Department of Health in England announced an ambition to reduce 'brain injuries occurring during or soon after birth'. We describe the development of a pragmatic case definition and present annual incidence rates. DESIGN: Retrospective cohort study using data held in the National Neonatal Research Database (NNRD) extracted from neonatal electronic patient records from all National Health Service (NHS) neonatal units in England, Wales and Scotland...
October 22, 2017: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://www.readbyqxmd.com/read/29162096/carer-involvement-in-compulsory-out-patient-psychiatric-care-in-england
#19
Jorun Rugkåsa, Krysia Canvin
BACKGROUND: There is an expectation in current heath care policy that family carers are involved in service delivery. This is also the case with compulsory outpatient mental health care, Community Treatment Orders (CTOs) that were introduced in England in 2008. No study has systematically investigated family involvement through the CTO process. METHOD: We conducted qualitative interviews with 24 family carers to ascertain their views and experiences of involvement in CTOs...
November 21, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/29161391/an-overview-of-space-medicine
#20
P D Hodkinson, R A Anderton, B N Posselt, K J Fong
Space medicine is fundamental to the human exploration of space. It supports survival, function and performance in this challenging and potentially lethal environment. It is international, intercultural and interdisciplinary, operating at the boundaries of exploration, science, technology and medicine. Space medicine is also the latest UK specialty to be recognized by the Royal College of Physicians in the UK and the General Medical Council. This review introduces the field of space medicine and describes the different types of spaceflight, environmental challenges, associated medical and physiological effects, and operational medical considerations...
December 1, 2017: British Journal of Anaesthesia
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