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https://www.readbyqxmd.com/read/28087691/imaging-proteins-at-the-single-molecule-level
#1
Jean-Nicolas Longchamp, Stephan Rauschenbach, Sabine Abb, Conrad Escher, Tatiana Latychevskaia, Klaus Kern, Hans-Werner Fink
Imaging single proteins has been a long-standing ambition for advancing various fields in natural science, as for instance structural biology, biophysics, and molecular nanotechnology. In particular, revealing the distinct conformations of an individual protein is of utmost importance. Here, we show the imaging of individual proteins and protein complexes by low-energy electron holography. Samples of individual proteins and protein complexes on ultraclean freestanding graphene were prepared by soft-landing electrospray ion beam deposition, which allows chemical- and conformational-specific selection and gentle deposition...
January 13, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28078429/aims-and-tasks-in-parental-caregiving-for-children-receiving-palliative-care-at-home-a-qualitative-study
#2
Lisa M Verberne, Marijke C Kars, Antoinette Y N Schouten-van Meeteren, Diederik K Bosman, Derk A Colenbrander, Martha A Grootenhuis, Johannes J M van Delden
: In paediatric palliative care (PPC), parents are confronted with increasing caregiving demands. More children are cared for at home, and the need for PPC of children is lengthened due to technical and medical improvements. Therefore, a clear understanding of the content of parental caregiving in PPC becomes increasingly important. The objective is to gain insight into parental caregiving based on the lived experience of parents with a child with a life-limiting disease. An interpretative qualitative study using thematic analysis was performed...
January 11, 2017: European Journal of Pediatrics
https://www.readbyqxmd.com/read/28076579/factors-that-influence-career-choice-in-primary-care-among-medical-students-starting-social-service-in-honduras
#3
E Benjamín Puertas, Tamara Y Rivera
Objective: To 1) describe patterns of specialty choice; 2) investigate relationships between career selection and selected demographic indicators; and 3) identify salary perception, factors that influence career choice in primary care, and factors that influence desired location of future medical practice. Methods: The study used a mixed-methods approach that included a cross-sectional questionnaire survey applied to 234 last-year medical students in Honduras (September 2014), and semi-structured interviews with eight key informants (October 2014)...
November 2016: Revista Panamericana de Salud Pública, Pan American Journal of Public Health
https://www.readbyqxmd.com/read/28049182/the-ambition-of-the-european-respiratory-journal-continues-chapter-5
#4
EDITORIAL
Marc Humbert, Anh Tuan Dinh-Xuan, Elin L Reeves, Matthew G Broadhead, Neil J Bullen
No abstract text is available yet for this article.
January 2017: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/28043952/implementing-electronic-records-in-nhs-secondary-care-organizations-in-england-policy-and-progress-since-1998
#5
REVIEW
Arabella Clarke, Ian Watt, Laura Sheard, John Wright, Joy Adamson
BACKGROUND: A number of different policies have aimed to introduce electronic records into National Health Service (NHS) secondary care organizations in England over recent years. There has been little formal attempt to explore the overall impact of these policies (as opposed to evaluations of individual initiatives) and how they have developed and progressed over time. SOURCES OF DATA: National NHS IT policy documents and evaluations of national NHS IT policy between 1998 and 2015...
January 1, 2017: British Medical Bulletin
https://www.readbyqxmd.com/read/28039187/initial-combination-therapy-with-ambrisentan-and-tadalafil-in-connective-tissue-disease-associated-pulmonary-arterial-hypertension-ctd-pah-subgroup-analysis-from-the-ambition-trial
#6
John Gerry Coghlan, Nazzareno Galiè, Joan Albert Barberà, Adaani E Frost, Hossein-Ardeschir Ghofrani, Marius M Hoeper, Masataka Kuwana, Vallerie V McLaughlin, Andrew J Peacock, Gérald Simonneau, Jean-Luc Vachiéry, Christiana Blair, Hunter Gillies, Karen L Miller, Julia H N Harris, Jonathan Langley, Lewis J Rubin
BACKGROUND: Patients with connective tissue disease-associated pulmonary arterial hypertension (CTD-PAH), in particular systemic sclerosis (SSc), had an attenuated response compared with idiopathic PAH in most trials. Thus, there is uncertainty regarding the benefit of PAH-targeted therapy in some forms of CTD-PAH. OBJECTIVE: To explore the safety and efficacy of initial combination therapy with ambrisentan and tadalafil versus ambrisentan or tadalafil monotherapy in patients with CTD-PAH and SSc-PAH enrolled in the AMBITION trial...
December 30, 2016: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28024361/monitoring-dynamic-cellular-redox-homeostasis-using-fluorescence-switchable-graphene-quantum-dots
#7
Nan Li, Aung Than, Chencheng Sun, Jingqi Tian, Jie Chen, Kanyi Pu, Xiaochen Dong, Peng Chen
Monitoring cellular redox homeostasis is critical to the understanding of many physiological functions ranging from immune reactions to metabolism, as well as to the understanding of pathological development ranging from tumorigenesis to aging. Nevertheless, there is currently a lack of appropriate probes for this ambition, which should be reversibly, sensitively, and promptly responsive to a wide range of physiological oxidants and reductants. In this work, a redox-sensitive fluorescence-switchable probe is designed based on graphene quantum dots (GQDs) functionalized with a chelated redox Fe(2+)/Fe(3+) couple...
December 27, 2016: ACS Nano
https://www.readbyqxmd.com/read/28018856/time-and-circumstances-cancer-cell-metabolism-at-various-stages-of-disease-progression
#8
REVIEW
Georg F Weber
Over the past decade, research into the unique ways, in which cancer cells skew their metabolism, has had a renaissance-for the repeated time over more than 80 years since the discovery of an inherent preference for glycolysis. Importantly, the Warburg effect that arises in primary neoplasms is not the sole prominent metabolic phenomenon. Once the transformed cells are shed from their initial growth and begin the process of metastasis, their energy requirements change and they adapt to the increased demand for adenosine triphosphate, which if not satisfied would lead to anoikis...
2016: Frontiers in Oncology
https://www.readbyqxmd.com/read/28009246/locating-risk-in-the-adolescent-brain-ethical-challenges-in-the-use-of-biomarkers-for-adolescent-health-and-social-policy
#9
Suparna Choudhury, Sheehan Moore
Technological developments in neuroscience over the last 20 years have generated excitement about the potential of neuroscientific insights for the understanding of and intervention in children's and adolescents' behavior. This article introduces some ways in which new results from developmental cognitive neuroscience have been appropriated in the context of adolescent mental health. We also consider social and interpersonal factors that drive the use of neurobiological markers of mental disorders in pediatric psychiatry...
December 1, 2016: AMA Journal of Ethics
https://www.readbyqxmd.com/read/28003793/visual-semantic-based-3d-video-retrieval-system-using-hdfs
#10
C Ranjith Kumar, S Suguna
This paper brings out a neoteric frame of reference for visual semantic based 3d video search and retrieval applications. Newfangled 3D retrieval application spotlight on shape analysis like object matching, classification and retrieval not only sticking up entirely with video retrieval. In this ambit, we delve into 3D-CBVR (Content Based Video Retrieval) concept for the first time. For this purpose, we intent to hitch on BOVW and Mapreduce in 3D framework. Instead of conventional shape based local descriptors, we tried to coalesce shape, color and texture for feature extraction...
August 2016: Data Mining and Knowledge Discovery
https://www.readbyqxmd.com/read/27998328/-apostles-of-continence-doctors-and-the-doctrine-of-sexual-necessity-in-progressive-era-america
#11
Timothy Verhoeven
In the first decades of the twentieth century, a group of doctors under the banner of the social hygiene movement set out on what seemed an improbable mission: to convince American men that they did not need sex. This was in part a response to venereal disease. Persuading young men to adopt the standard of sexual discipline demanded of women was the key to preserving the health of the nation from the ravages of syphilis and gonorrhoea. But their campaign ran up against the doctrine of male sexual necessity, a doctrine well established in medical thought and an article of faith for many patients...
January 2017: Medical History
https://www.readbyqxmd.com/read/27986235/building-a-sustainable-global-surgery-nonprofit-organization-at-an-academic-institution
#12
Margaret M Frisella
BACKGROUND: Surgical Outreach for the Americas is a 501(c)3 nonprofit organization providing surgical care to those in need in developing countries of the Western Hemisphere. Every year since its inception in 2008, teams of surgeons, nurses, and allied health professionals have traveled to areas of need and performed primarily hernia repair surgeries for those without access to affordable health care. METHODS: Surgical Outreach for the Americas (SOfA) began as a general concept based on World Health Organization statistics claiming that 11% of the global burden of disease can be resolved via surgery...
July 2016: Annals of Global Health
https://www.readbyqxmd.com/read/27958674/gaining-momentum-sulfonimidamides-in-medicinal-and-agrochemistry
#13
Praveen K Chinthakindi, Tricia Naicker, Niranjan Thota, Thavendran Govender, Hendrik G Kruger, Per I Arvidsson
Synthesis and evaluation of structural analogues and isosteres represent a cornerstone methodology among the practitioners of medicinal- and agrochemistry. The sulfonamide functional group represents one of the most important amide isosteres in contemporary drug design, with some 500 compounds that has overcome both the pharmacological and regulatory hurdles that precede studies in humans. We note that mono aza-analogues of sulfonamides, i.e. sulfonimidamides, are rapidly gaining popularity as a novel functional group among molecular architects involved in the design of biologically active compounds for both pharmaceutical- and agrochemical applications...
December 13, 2016: Angewandte Chemie
https://www.readbyqxmd.com/read/27942074/modelling-and-the-nation-institutionalising-climate-prediction-in-the-uk-1988-92
#14
Martin Mahony, Mike Hulme
How climate models came to gain and exercise epistemic authority has been a key concern of recent climate change historiography. Using newly released archival materials and recently conducted interviews with key actors, we reconstruct negotiations between UK climate scientists and policymakers which led to the opening of the Hadley Centre for Climate Prediction and Research in 1990. We historicize earlier arguments about the unique institutional culture of the Hadley Centre, and link this culture to broader characteristics of UK regulatory practice and environmental politics...
2016: Minerva
https://www.readbyqxmd.com/read/27942029/predictors-of-participation-of-sophomore-medical-students-in-a-health-promoting-intervention-an-observational-study
#15
Thomas Kötter, Johanna Ritter, Alexander Katalinic, Edgar Voltmer
Medical students and doctors have to be particularly stress-resilient, as both medical education and practice are considered very stressful. Specific stressors can lead to increased risks of developing, for example, depression, anxiety and burnout. Relaxation techniques have proven to be effective for the prevention of these outcomes in student populations. However, only a very few medical students practice relaxation techniques regularly early on in their studies. Furthermore, it is unclear which students make use of stress-management offers and hence whether vulnerable students are generally reachable...
2016: PloS One
https://www.readbyqxmd.com/read/27941159/identifying-barriers-to-diagnosing-dementia-following-incentivisation-and-policy-pressures-general-practitioners-perspectives
#16
Anita Chithiramohan, Steve Iliffe, Iram Khattak
Overcoming barriers to earlier diagnosis of dementia in primary care is a core ambition of several government initiatives in the UK, with incentives put in place to promote earlier recognition by general practitioners and referral to specialists. This study was designed to explore general practitioners' opinions concerning barriers to diagnosing dementia, following implementation of strategies aimed at reducing them. The study involved in-depth, semi-structured interviews with 13 general practitioners from seven practices in North London or the West Midlands...
December 9, 2016: Dementia
https://www.readbyqxmd.com/read/27932869/person-centered-dementia-care-current-perspectives
#17
REVIEW
Jill Manthorpe, Kritika Samsi
Person-centered dementia care is widely accepted as a value-based commitment to supporting people with dementia and is a guiding principle in care services. Policy ambitions to put people at the center of their own care are being developed internationally. These may be seen as part of the evolution of person-centered care which has its origins in critical perspectives on practice and social responses to people with dementia. In England, one further development of person-centered care has been personalization - a government policy to extend individuals' choice and control over their social care and, latterly, ways to meet their health care needs...
2016: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/27928825/patient-involvement-in-own-rehabilitation-after-early-discharge
#18
Britta Hørdam, Merete Watt Boolsen
BACKGROUND: A European Union Commission report in 2015 concluded that the concept of patient involvement refers specially to the right of patients to have a central position in the healthcare process (EU Commission 2012, http://ec.europa.eu/public_opinion/archives/quali/ql_5937_patient_en.pdf). Recent research suggests that patient involvement after hip replacement is a very effective strategy in older adults with regard to improving walking ability and reducing pain and thereby lessening loss of physical, mental and social aspects of the quality of life...
December 8, 2016: Scandinavian Journal of Caring Sciences
https://www.readbyqxmd.com/read/27909416/combining-gender-work-and-family-identities-the-cross-over-and-spill-over-of-gender-norms-into-young-adults-work-and-family-aspirations
#19
Loes Meeussen, Jenny Veldman, Colette Van Laar
The current study investigates how descriptive and prescriptive gender norms that communicate work and family identities to be (in)compatible with gender identities limit or enhance young men and women's family and career aspirations. Results show that young adults (N = 445) perceived gender norms to assign greater compatibility between female and family identities and male and work identities than vice versa, and that young men and women mirror their aspirations to this traditional division of tasks. Spill-over effects of norms across life domains and cross-over effects of norms across gender-groups indicated that young women, more than young men, aimed to 'have it all': mirroring their career ambitions to a male career model, while keeping their family aspirations high...
2016: Frontiers in Psychology
https://www.readbyqxmd.com/read/27909081/five-year-efficacy-and-safety-of-tocilizumab-monotherapy-in-patients-with-rheumatoid-arthritis-who-were-methotrexate-and-biologic-naive-or-free-of-methotrexate-for-6-months-the-ambition-study
#20
Graeme Jones, Thomas Wallace, Matthew J McIntosh, Laura Brockwell, Juan J Gómez-Reino, Anthony Sebba
OBJECTIVE: To report on the 5-year efficacy and safety results of the AMBITION (Actemra versus Methotrexate double-Blind Investigative Trial In mONotherapy) monotherapy study (ClinicalTrials.gov: NCT00109408, NCT00720798). METHODS: Patients with rheumatoid arthritis for whom biologics had not failed or who did not discontinue methotrexate because of lack of efficacy or tolerability were followed up for 5 years to assess the efficacy and serious adverse events (SAE) of tocilizumab (TCZ) monotherapy...
December 1, 2016: Journal of Rheumatology
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