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https://www.readbyqxmd.com/read/27909416/combining-gender-work-and-family-identities-the-cross-over-and-spill-over-of-gender-norms-into-young-adults-work-and-family-aspirations
#1
Loes Meeussen, Jenny Veldman, Colette Van Laar
The current study investigates how descriptive and prescriptive gender norms that communicate work and family identities to be (in)compatible with gender identities limit or enhance young men and women's family and career aspirations. Results show that young adults (N = 445) perceived gender norms to assign greater compatibility between female and family identities and male and work identities than vice versa, and that young men and women mirror their aspirations to this traditional division of tasks. Spill-over effects of norms across life domains and cross-over effects of norms across gender-groups indicated that young women, more than young men, aimed to 'have it all': mirroring their career ambitions to a male career model, while keeping their family aspirations high...
2016: Frontiers in Psychology
https://www.readbyqxmd.com/read/27909081/five-year-efficacy-and-safety-of-tocilizumab-monotherapy-in-patients-with-rheumatoid-arthritis-who-were-methotrexate-and-biologic-naive-or-free-of-methotrexate-for-6-months-the-ambition-study
#2
Graeme Jones, Thomas Wallace, Matthew J McIntosh, Laura Brockwell, Juan J Gómez-Reino, Anthony Sebba
OBJECTIVE: To report on the 5-year efficacy and safety results of the AMBITION (Actemra versus Methotrexate double-Blind Investigative Trial In mONotherapy) monotherapy study (ClinicalTrials.gov: NCT00109408, NCT00720798). METHODS: Patients with rheumatoid arthritis for whom biologics had not failed or who did not discontinue methotrexate because of lack of efficacy or tolerability were followed up for 5 years to assess the efficacy and serious adverse events (SAE) of tocilizumab (TCZ) monotherapy...
December 1, 2016: Journal of Rheumatology
https://www.readbyqxmd.com/read/27905261/beneath-the-sword-of-damocles-regenerative-medicine-and-the-shadow-of-immunogenicity
#3
Paul J Fairchild, Christopher Horton, Priyoshi Lahiri, Kumaran Shanmugarajah, Timothy J Davies
Few topics in regenerative medicine have inspired such impassioned debate as the immunogenicity of cell types and tissues differentiated from pluripotent stem cells. While early predictions suggested that tissues derived from allogeneic sources may evade immune surveillance altogether, the pendulum has since swung to the opposite extreme, with reports that the ectopic expression of a few developmental antigens may prompt rejection, even of tissues differentiated from autologous cell lines. Here we review the evidence on which these contradictory claims are based in order to reach an objective assessment of the likely magnitude of the immunological challenges ahead...
December 2016: Regenerative Medicine
https://www.readbyqxmd.com/read/27896967/methods-to-ensure-the-reproducibility-of-biomedical-research
#4
Konrad J Karczewski, Nicholas P Tatonetti, Arjun K Manrai, Chirag J Patel, C Titus Brown, John P A Ioannidis
Science is not done in a vacuum - across fields of biomedicine, scientists have built on previous research and used data published in previous papers. A mainstay of scientific inquiry is the publication of one's research and recognition for this work is given in the form of citations and notoriety - ideally given in proportion to the quality of the work. Academic incentives, however, may encourage individual researchers to prioritize career ambitions over scientific truth. Recently, the New England Journal of Medicine published a commentary calling scientists who repurpose data "research parasites" who misuse data generated by others to demonstrate alternative hypotheses...
2016: Pacific Symposium on Biocomputing
https://www.readbyqxmd.com/read/27896605/personalized-medicine-in-a-new-genomic-era-ethical-and-legal-aspects
#5
Maria Shoaib, Mansoor Ali Merchant Rameez, Syed Ather Hussain, Mohammed Madadin, Ritesh G Menezes
The genome of two completely unrelated individuals is quite similar apart from minor variations called single nucleotide polymorphisms which contribute to the uniqueness of each and every person. These single nucleotide polymorphisms are of great interest clinically as they are useful in figuring out the susceptibility of certain individuals to particular diseases and for recognizing varied responses to pharmacological interventions. This gives rise to the idea of 'personalized medicine' as an exciting new therapeutic science in this genomic era...
November 28, 2016: Science and Engineering Ethics
https://www.readbyqxmd.com/read/27896385/pictorial-review-the-pearls-and-pitfalls-of-the-radiological-manifestations-of-gallstone-ileus
#6
REVIEW
Phei Shan Chuah, John Curtis, Nikhil Misra, Dina Hikmat, Sumita Chawla
We present a pictorial review of a range of typical and atypical cases of gallstone ileus (GI), across a wide range of imaging modalities. GI is a complication of gallstone disease causing mechanical intestinal obstruction due to impaction of gallstone in the gastrointestinal tract. The spectrum of presentation can vary enormously, and we highlight the importance of accurate imaging diagnosis of GI especially early use of computed tomography. This will lead to timely and appropriate surgical intervention with the potential avoidance of unnecessary outcomes...
November 28, 2016: Abdominal Radiology
https://www.readbyqxmd.com/read/27885038/design-fiction-and-the-medical-humanities
#7
Christopher Gordon Strachan
This paper sets out to explore the similarities between the developing discipline of speculative and critical design (SCD) and science fiction, and their relevance to the medical humanities. SCD looks beyond 'commercial design' to consider what sort of things we should, or should not, be designing in order to create preferable futures. It does so by extrapolating from current social, economic, political and scientific knowledge, designing artefacts, experiences and scenarios which communicate futures and alternative realities in tangible ways...
December 2016: Medical Humanities
https://www.readbyqxmd.com/read/27884083/the-globalisation-strategies-of-five-asian-tobacco-companies-an-analytical-framework
#8
Kelley Lee, Jappe Eckhardt
With 30% of the world's smokers, two million deaths annually from tobacco use, and rising levels of tobacco consumption, the Asian region is recognised as central to the future of global tobacco control. There is less understanding, however, of how Asian tobacco companies with regional and global aspirations are contributing to the global burden of tobacco-related disease and death. This introductory article sets out the background and rationale for this special issue on 'The Emergence of Asian Tobacco Companies: Implications for Global Health Governance' the globalisation of the Asian tobacco industry...
November 25, 2016: Global Public Health
https://www.readbyqxmd.com/read/27879455/diagnostic-care-pathways-in-dementia-a-review-of-the-involvement-of-primary-care-in-practice-and-innovation
#9
REVIEW
Christine E Wells, Sarah J Smith
OBJECTIVES: Increasing diagnostic rates of dementia is a national health priority; to meet this priority, improvement needs to be made to diagnostic services. It has been increasingly recognized that primary can play a significant role in the diagnostic journey for people with dementia, with some diagnostic services entirely located in primary care. This article reviews the extent of the involvement of primary care in diagnostic care pathways for people presenting with memory complaints within England, and presents examples of innovative approaches, which may be of interest to practitioners...
November 22, 2016: Journal of Primary Care & Community Health
https://www.readbyqxmd.com/read/27866835/over-using-chemotherapy-in-the-adjuvant-setting
#10
Giuseppe Curigliano, Carmen Criscitiello, Angela Esposito, Giancarlo Pruneri
Avoidance of unnecessary or ineffective treatment should be one of the main goals in adjuvant breast oncology today. Unfortunately, both patients and doctors hunt for tiny statistical differences in survival curves. This search could not only lead to an oncological approach of unlimited addition that we will not be able to afford, but would also end inevitably in indeterminate overtreatment with substantial risks of unexpected toxic effects eating away whatever progress we might make. "Do not harm" remains the main principle in medicine...
November 17, 2016: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/27866153/exploring-personality-and-readiness-to-change-in-patients-with-substance-use-disorders-with-and-without-adhd
#11
L Flores-García, E Ytterstad, M B Lensing, M Eisemann
OBJECTIVE: To explore personality and readiness to change among substance use disorders (SUD) patients with and without ADHD. METHOD: SUD + ADHD versus SUD - ADHD patients consecutively entering treatment between 2010 and 2012 were compared concerning personality (Temperament and Character Inventory) and readiness to change (Stages of Change Readiness and Treatment Eagerness Scale). RESULTS: Among 103 SUD patients (76 men, age M = 43.3, SD = 11...
November 19, 2016: Journal of Attention Disorders
https://www.readbyqxmd.com/read/27817927/assessing-the-cumulative-environmental-effects-of-marine-renewable-energy-developments-establishing-common-ground
#12
REVIEW
Edward Willsteed, Andrew B Gill, Silvana N R Birchenough, Simon Jude
Assessing and managing the cumulative impacts of human activities on the environment remains a major challenge to sustainable development. This challenge is highlighted by the worldwide expansion of marine renewable energy developments (MREDs) in areas already subject to multiple activities and climate change. Cumulative effects assessments in theory provide decision makers with adequate information about how the environment will respond to the incremental effects of licensed activities and are a legal requirement in many nations...
January 15, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/27803210/can-multiple-mini-interviews-predict-academic-performance-of-dental-students-a-two-year-follow-up
#13
Sumer M Alaki, Ibrahim A Yamany, Lana A Shinawi, Mona H A Hassan, Ara Tekian
Prior research has shown that students' previous grade point average (GPA) is the best predictor for future academic success. However, it can only partly predict the variability in dental school performance. The aim of this study was to assess the predictive value of multiple mini-interviews (MMI) as an admission criterion by comparing them with the academic performance of dental students over a two-year period. All incoming undergraduate dental students at the King Abdulaziz University Faculty of Dentistry (KAUFD) during academic year 2013-14 were invited to participate in MMI...
November 2016: Journal of Dental Education
https://www.readbyqxmd.com/read/27792434/expanding-the-use-of-digital-technology-across-the-nhs
#14
Alan Glasper
Emeritus Professor Alan Glasper, from the University of Southampton, discusses the Government's ambition to roll out advances in digital healthcare technology to improve patient care in the NHS.
October 27, 2016: British Journal of Nursing: BJN
https://www.readbyqxmd.com/read/27787576/-gut-microbiome-and-major-depressive-disorder-the-other-side-of-ourselves
#15
A Manook, A Hiergeist, R Rupprecht, T C Baghai
Microbiological ecology and its ambition to describe the complete genome of complex living communities as a whole, have given us powerful tools to characterize the human gut microbiome on a genetic and, hence, taxonomic and abundance level; for a decade now, they have become sufficiently inexpensive, fast and feasible. Thus, opportunities arose to have a fresh and closer look at the microbiota-gut-brain-axis and its impact on human health; this axis comprises a complex multisystemic network of multidirectional interactions between brain and gut including influences beyond one generation...
October 27, 2016: Der Nervenarzt
https://www.readbyqxmd.com/read/27764048/anesthesiology-mentoring
#16
Volker Wenzel, Nikolaus Gravenstein
PURPOSE OF REVIEW: Mentoring is fundamentally valuable and important to students considering a path into our specialty, as well as to colleagues already in it and with ambition to advance. General principles and personal experiences are collected and described to help inform future mentors and to reinforce the value of having a mentor and the satisfaction (and work) that is associated with such a role. RECENT FINDINGS: Detecting a latent talent among medical students or residents may be challenging but is worth the effort to develop personal careers and the specialty itself...
December 2016: Current Opinion in Anaesthesiology
https://www.readbyqxmd.com/read/27755168/mesenchymal-stromal-cells-in-clinical-kidney-transplantation-how-tolerant-can-it-be
#17
Cees van Kooten, Ton J Rabelink, Johan W de Fijter, Marlies E J Reinders
PURPOSE OF REVIEW: Progress in the improvement of short-term and long-term outcomes of kidney transplantation seems to have reached a plateau, partially due to consequences of very efficient, but nonspecific immunosuppressive drugs. In recent years, various forms of cell therapy, including the use of mesenchymal stromal cells, have been put forward as an alternative strategy for more defined therapy. It is thought that these therapies will not only allow controlled tapering of immunosuppressive medication, but might bring us also closer to the ambition of generating donor-specific immune regulation and tolerance...
October 15, 2016: Current Opinion in Organ Transplantation
https://www.readbyqxmd.com/read/27749248/tlc-determination-of-flavonoids-from-different-cultivars-of-allium-cepa-and-allium-ascalonicum
#18
Loretta Pobłocka-Olech, Daniel Głód, Maria E Żebrowska, Małgorzata Sznitowska, Miroslawa Krauze-Baranowska
This study comprises the optimization and validation of a new TLC method for determination of flavonols in the bulbs of seven cultivars of onions and shallots. Separation was performed on RP-18 plates with the solvent mixture tetrahydrofuran/water/formic acid (40+60+6, V/V/V) as a mobile phase. The method was evaluated for precision, linearity, LOD, LOQ, accuracy and robustness. Chromatographic analysis of the extracts revealed the presence of three main flavonols, quercetin, quercetin-4'-O-glucoside and quercetin-3,4'-O-diglucoside in the majority of analyzed cultivars...
December 1, 2016: Acta Pharmaceutica
https://www.readbyqxmd.com/read/27745818/initial-combination-therapy-with-ambrisentan-and-tadalafil-and-mortality-in-patients-with-pulmonary-arterial-hypertension-a-secondary-analysis-of-the-results-from-the-randomised-controlled-ambition-study
#19
Marius M Hoeper, Vallerie V McLaughlin, Joan Albert Barberá, Adaani E Frost, Hossein-Ardeschir Ghofrani, Andrew J Peacock, Gérald Simonneau, Stephan Rosenkranz, Ronald J Oudiz, R James White, Karen L Miller, Jonathan Langley, Julia H N Harris, Christiana Blair, Lewis J Rubin, Jean-Luc Vachiery
BACKGROUND: In treatment-naive patients with pulmonary arterial hypertension, initial combination therapy with ambrisentan and tadalafil reduces the risk of clinical failure events compared with monotherapy. We did this secondary analysis to further investigate the effect of combination therapy on survival. METHODS: We analysed survival data from the modified intention-to-treat population of the Ambrisentan and Tadalafil in Patients with Pulmonary Arterial Hypertension (AMBITION) trial...
October 10, 2016: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/27737622/the-china-national-tobacco-corporation-from-domestic-to-global-dragon
#20
Jennifer Fang, Kelley Lee, Nidhi Sejpal
The China National Tobacco Corporation (CNTC), which produces one-third of the world's cigarettes, is the largest tobacco company in the world. Over the past 60 years, the CNTC has been focused on supplying a huge domestic market. As the market has become increasingly saturated, and potential foreign competition looms, the company has turned to expansion abroad. This paper examines the ambitions and prospects of the CNTC to 'go global'. Using Chinese and English language sources, this paper describes the globalisation ambitions of the CNTC, and its global business strategy focused on internal restructuring, brand development and expansion of overseas operations in selected markets...
October 13, 2016: Global Public Health
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