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https://www.readbyqxmd.com/read/28426890/fine-mapping-of-lipid-regions-in-global-populations-discovers-ethnic-specific-signals-and-refines-previously-identified-lipid-loci
#1
Niha Zubair, Mariaelisa Graff, Jose Luis Ambite, William S Bush, Gleb Kichaev, Yingchang Lu, Ani Manichaikul, Wayne H-H Sheu, Devin Absher, Themistocles L Assimes, Suzette J Bielinski, Erwin P Bottinger, Petra Buzkova, Lee-Ming Chuang, Ren-Hua Chung, Barbara Cochran, Logan Dumitrescu, Omri Gottesman, Jeffrey W Haessler, Christopher Haiman, Gerardo Heiss, Chao A Hsiung, Yi-Jen Hung, Chii-Min Hwu, Jyh-Ming J Juang, Loic Le Marchand, I-Te Lee, Wen-Jane Lee, Li-An Lin, Danyu Lin, Shih-Yi Lin, Rachel H Mackey, Lisa W Martin, Bogdan Pasaniuc, Ulrike Peters, Irene Predazzi, Thomas Quertermous, Alex P Reiner, Jennifer Robinson, Jerome I Rotter, Kelli K Ryckman, Pamela J Schreiner, Eli Stahl, Ran Tao, Michael Y Tsai, Lindsay L Waite, Tzung-Dau Wang, Steven Buyske, Yii-Der Ida Chen, Iona Cheng, Dana C Crawford, Ruth J F Loos, Stephen S Rich, Myriam Fornage, Kari E North, Charles Kooperberg, Cara L Carty
Genome-wide association studies have identified over 150 loci associated with lipid traits, however, no large-scale studies exist for Hispanics and other minority populations. Additionally, the genetic architecture of lipid-influencing loci remains largely unknown. We performed one of the most racially/ethnically diverse fine-mapping genetic studies of HDL-C, LDL-C, and triglycerides to-date using SNPs on the MetaboChip array on 54,119 individuals: 21,304 African Americans, 19,829 Hispanic Americans, 12,456 Asians, and 530 American Indians...
December 15, 2016: Human Molecular Genetics
https://www.readbyqxmd.com/read/28425346/ambrisentan-a-review-of-its-use-in-pulmonary-arterial-hypertension
#2
Belinda N Rivera-Lebron, Michael G Risbano
Pulmonary arterial hypertension (PAH) is a progressive disease defined by an elevation in pulmonary arterial pressure that can lead to right heart failure and death. Ambrisentan is a selective endothelin receptor antagonist approved for the treatment of idiopathic, heritable PAH and connective tissue disease-associated PAH. Ambrisentan has been shown to improve exercise capacity and hemodynamics with an acceptable side-effect profile. It has also proven to be safely used in combination with other PAH-specific medications, especially with phosphodiesterase-5 inhibitors...
April 1, 2017: Therapeutic Advances in Respiratory Disease
https://www.readbyqxmd.com/read/28423792/acronym-disambiguation-in-spanish-electronic-health-narratives-using-machine-learning-techniques
#3
Ignacio Rubio-López, Roberto Costumero, Héctor Ambit, Consuelo Gonzalo-Martín, Ernestina Menasalvas, Alejandro Rodríguez González
Electronic Health Records (EHRs) are now being massively used in hospitals what has motivated current developments of new methods to process clinical narratives (unstructured data) making it possible to perform context-based searches. Current approaches to process the unstructured texts in EHRs are based in applying text mining or natural language processing (NLP) techniques over the data. In particular Named Entity Recognition (NER) is of paramount importance to retrieve specific biomedical concepts from the text providing the semantic type of the concept retrieved...
2017: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/28406202/finding-pathways-to-national-scale-land-sector-sustainability
#4
Lei Gao, Brett A Bryan
The 17 Sustainable Development Goals (SDGs) and 169 targets under Agenda 2030 of the United Nations map a coherent global sustainability ambition at a level of detail general enough to garner consensus amongst nations. However, achieving the global agenda will depend heavily on successful national-scale implementation, which requires the development of effective science-driven targets tailored to specific national contexts and supported by strong national governance. Here we assess the feasibility of achieving multiple SDG targets at the national scale for the Australian land-sector...
April 12, 2017: Nature
https://www.readbyqxmd.com/read/28383620/-integrated-project-of-personalisation-school-curricula-and-training
#5
A Zanon, R Tomassoni, N Santangelo, M Gargano, E Treglia, M G Granai, A Incagnoli
OBJECTIVES: To strengthen the motivation to study, promote awareness of their attitudes and actions of orientation / re-orientation to the profession, making the learning experience more stimulating and training in order to staunch the sharp drop-out affecting the school. MATERIALS AND METHODS: The project, coordinated by psychologists, involved the administration of AMOS Test as a tool to detect the variables of interest (self-image, ambitions and motivations, concerns for the future, soft skills etc...
March 2017: La Clinica Terapeutica
https://www.readbyqxmd.com/read/28382670/marijuana-and-alcohol-use-as-predictors-of-academic-achievement-a-longitudinal-analysis-among-youth-in-the-compass-study
#6
Karen A Patte, Wei Qian, Scott T Leatherdale
BACKGROUND: We tested the effect of initiating marijuana and alcohol use at varying frequencies on academic indices. METHODS: In a sample of 26,475 grade 9-12 students with at least 2 years of linked longitudinal data from year 1 (Y1: 2012-2013), year 2 (Y2: 2013-2014), and year 3 (Y3: 2014-2015) of the COMPASS study, separate multinomial generalized estimating equations models tested the likelihood of responses to measures of academic goals, engagement, preparedness, and performance when shifting from never using alcohol or marijuana at baseline to using them at varying frequencies at follow -up...
May 2017: Journal of School Health
https://www.readbyqxmd.com/read/28380003/cause-of-death-in-patients-with-poststroke-epilepsy-results-from-a-nationwide-cohort-study
#7
Julia Hansen, Signild Åsberg, Eva Kumlien, Johan Zelano
The risk of death is increased for persons with epilepsy. The literature on causes of death in epilepsy is based mainly on cohorts with epilepsy of mixed aetiologies. For clinical purposes and improved understanding of mortality in different epilepsies, more information is needed on mortality in epilepsies of specific causes. In poststroke epilepsy (PSE), seizures occur in a setting of vascular disease and high mortality rates. The extent to which epilepsy contributes to mortality in this patient group is poorly understood...
2017: PloS One
https://www.readbyqxmd.com/read/28375501/seven-ethical-issues-affecting-neurosurgeons-in-the-context-of-health-care-reform
#8
T Forcht Dagi
Ethical discussions around health care reform typically focus on problems of social justice and health care equity. This review, in contrast, focuses on ethical issues of particular importance to neurosurgeons, especially with respect to potential changes in the physician-patient relationship that may occur in the context of health care reform.The Patient Protection and Affordable Care Act (ACA) of 2010 (H.R. 3590) was not the first attempt at health care reform in the United States but it is the one currently in force...
April 1, 2017: Neurosurgery
https://www.readbyqxmd.com/read/28367679/initial-perceptions-of-palliative-care-an-exploratory-qualitative-study-of-patients-with-advanced-cancer-and-their-family-caregivers
#9
Anna Collins, Sue-Anne McLachlan, Jennifer Philip
BACKGROUND: Despite evidence for early integration of palliative care for people with advanced cancer and their families, patterns of late engagement continue. Prior research has focused on health professionals' attitudes to palliative care with few studies exploring the views of patients and their carers. AIM: To explore initial perceptions of palliative care when this is first raised with patients with advanced cancer and their families in Australian settings...
March 1, 2017: Palliative Medicine
https://www.readbyqxmd.com/read/28336805/what-is-data-ethics
#10
Luciano Floridi, Mariarosaria Taddeo
This theme issue has the founding ambition of landscaping data ethics as a new branch of ethics that studies and evaluates moral problems related to data (including generation, recording, curation, processing, dissemination, sharing and use), algorithms (including artificial intelligence, artificial agents, machine learning and robots) and corresponding practices (including responsible innovation, programming, hacking and professional codes), in order to formulate and support morally good solutions (e.g. right conducts or right values)...
December 28, 2016: Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences
https://www.readbyqxmd.com/read/28336507/planking-or-the-lying-down-game-two-case-reports
#11
Stefania Barbieri, Paolo Feltracco, Luca Omizzolo, Rossella Snenghi, Rafi El Mazloum, Gianna Vettore, Mauro Bergamini, Armando Stefanati, Daniele Donato, Cecilia Ferronato, Francesco Maria Avato, Alberto Tredese, Rosa Maria Gaudio
BACKGROUND: The monitoring and management of risks regarding children and young people admitted to the emergency department as a result of dangerous behaviors distributed via the Internet should be based on clinical reasoning and knowledge about these social media-related phenomena. Here we examine 2 cases of teenagers who reported severe injuries while performing the "planking" craze, a challenge that consists in lying face-down stiffly like a board on any kind of surface. OBJECTIVE: Our objective is to examine and describe the Internet craze called planking, also known as the "lying-down game," through 2 case reports from our experience, enriching this study with information gained through discussions with secondary school teenagers...
March 23, 2017: Interactive Journal of Medical Research
https://www.readbyqxmd.com/read/28336427/high-resolution-anatomical-and-quantitative-mri-of-the-entire-human-occipital-lobe-ex-vivo-at-9-4t
#12
S Sengupta, F J Fritz, R L Harms, S Hildebrand, D H Y Tse, B A Poser, R Goebel, A Roebroeck
Several magnetic resonance imaging (MRI) contrasts are sensitive to myelin content in gray matter in vivo which has ignited ambitions of MRI-based in vivo cortical histology. Ultra-high field (UHF) MRI, at fields of 7T and beyond, is crucial to provide the resolution and contrast needed to sample contrasts over the depth of the cortex and get closer to layer resolved imaging. Ex vivo MRI of human post mortem samples is an important stepping stone to investigate MRI contrast in the cortex, validate it against histology techniques applied in situ to the same tissue, and investigate the resolutions needed to translate ex vivo findings to in vivo UHF MRI...
March 20, 2017: NeuroImage
https://www.readbyqxmd.com/read/28333786/the-bundled-care-disruption
#13
Carol Anne Boston-Fleischhauer
The new administration and Congress will wrestle with the Affordable Care Act and options. In the meantime, several reimbursement programs designed to disrupt current approaches to patient care delivery continue, including the Centers for Medicare & Medicaid Services bundled payment program. Chief nurse executives must prepare to advance processes and care models that align with bundled payments and the broader ambition to eliminate care variation.
April 2017: Journal of Nursing Administration
https://www.readbyqxmd.com/read/28330567/a-new-year-a-new-journal-new-ambitions
#14
EDITORIAL
C Meyer
No abstract text is available yet for this article.
February 2017: Journal of Stomatology, Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28326722/-application-of-team-approach-and-key-techniques-of-cleft-lip-and-palate
#15
Shi Bing, Fu Yuchuan, Yin Ningbei, Huang Hong-Zhang, Liu Jianhua, Chen Renji, Zhu Hongping, Liu Qiang, Huang Yongqing, Ren Zhanping, Lu Yong, Xiao Wenlin, Song Qinggao, Li Wanshan, Li Sheng, Wang Hongtao, Zhang Junrui, Jiang Liping, Ma Li, Wang Ling, He Dengqi
The development of an expert consensus based on specific domestic situations will provide practical guidance to the efforts aiming at improving cleft care in China. The team approach of twenty-one cleft centers were pooled together, covering pre-surgical orthopedics, primary surgical repair, orthodontic treatment, alveolar bone graft, secondary deformity correction, palatal fistulae repair, the diagnosis and treatment of velopharyngeal incompetence, speech therapy, otitis media management, and skeletal deformity correction...
February 1, 2017: Hua Xi Kou Qiang Yi Xue za Zhi, Huaxi Kouqiang Yixue Zazhi, West China Journal of Stomatology
https://www.readbyqxmd.com/read/28304332/a-wellness-mobile-application-for-smart-health-pilot-study-design-and-results
#16
Giovanna Sannino, Manolo Forastiere, Giuseppe De Pietro
Wellness is one of the main factors crucial in the avoidance of illness or disease. Experience has shown that healthy lifestyle programs are an important strategy to prevent the major shared risk factors for many diseases including cardiovascular diseases, strokes, diabetes, obesity, and hypertension. Within the ambit of the Smart Health 2.0 project, a Wellness App has been developed which has the aim of providing people with something similar to a personal trainer. This Wellness App is able to gather information about the subject, to classify her/him by evaluating some of her/his specific characteristics (physical parameters and lifestyle) and to make personal recommendations to enhance her/his well-being...
March 17, 2017: Sensors
https://www.readbyqxmd.com/read/28303232/scandinavian-exceptionalism-civic-integration-and-labour-market-activation-for-newly-arrived-immigrants
#17
Karen N Breidahl
Since the late 1990s, a wide range of so-called new civic integration policies aimed at civilizing or disciplining newcomers have been introduced. Consequently, migration scholars have discussed whether a converging restrictive 'civic turn' has taken place in Western Europe or whether national models have been resilient: Based on an in-depth historical and comparative analysis of labour market activation policies targeting newly arrived immigrants in Sweden, Norway, and Denmark since the early 1990s, the article contributes to the overall question: To what extent do the institutional pathways of the Scandinavian welfare states prevail when confronted with newcomers? Activation policies targeting newly arrived immigrants exemplifies how the ambition of states to promote functional, individual autonomy is also an important, ongoing process in diverse policy areas of the welfare state and not restricted to early integration instruments...
2017: Comparative Migration Studies
https://www.readbyqxmd.com/read/28297888/elasticity-of-smectic-liquid-crystals-with-in-plane-orientational-order-and-dispiration-asymmetry
#18
Jaya Kumar Alageshan, Buddhapriya Chakrabarti, Yashodhan Hatwalne
The Nelson-Peliti formulation of the elasticity theory of isolated fluid membranes with orientational order emphasizes the interplay between geometry, topology, and thermal fluctuations. Fluid layers of lamellar liquid crystals such as smectic-C, hexatic smectics, and smectic-C^{*} are endowed with in-plane orientational order. We extend the Nelson-Peliti formulation so as to bring these smectics within its ambit. Using the elasticity theory of smectics-C^{*}, we show that positive and negative dispirations (topological defects in Smectic-C^{*} liquid crystals) with strengths of equal magnitude have disparate energies-a result that is amenable to experimental tests...
February 2017: Physical Review. E
https://www.readbyqxmd.com/read/28293228/prevention-and-control-strategies-to-counter-zika-epidemic
#19
REVIEW
Irfan A Rather, Sanjay Kumar, Vivek K Bajpai, Jeongheui Lim, Yong-Ha Park
ZIKA virus (ZIKA) has now become a global phenomenon. Since 2007, evidence of ZIKA transmission has been reported over 72 countries and territories. The transmission of ZIKA has made World Health Organization to categorize the situation under the ambit of a health emergency. This situation is serious because there appears to be a highly tangible link between infection during pregnancy and the occurrence of microcephaly and Guillain-Barré syndrome. In the context of this emergency situation, this review article intends to discuss the prevention and control strategies such as avoiding travel to infected area, being careful from mosquito bites, take precautions to reduce the risk of sexual transmission, and seek medical care for any acute illness with rash or fever...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28288580/important-aspects-in-relation-to-patients-attendance-at-exercise-based-cardiac-rehabilitation-facilitators-barriers-and-physiotherapist-s-role-a-qualitative-study
#20
Maria Bäck, Birgitta Öberg, Barbro Krevers
BACKGROUND: In order to improve attendance at exercise-based cardiac rehabilitation (CR), a greater insight into patients' perspectives is necessary. The aim of the study was to explore aspects that influence patients' attendance at exercise-based CR after acute coronary artery disease (CAD) and the role of the physiotherapist in patients' attendance at exercise-based CR. METHODS: A total of 16 informants, (5 women; median age 64.5, range 47-79 years), diagnosed with CAD, were included in the study at the Cardiology Department, Linköping University Hospital, Sweden...
March 14, 2017: BMC Cardiovascular Disorders
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