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Simon Innes, chief executive of CVS, shares his thoughts on vet salaries, recruitment challenges and his ambition for CVS global domination. By Adele Waters.
March 17, 2018: Veterinary Record
Eli Gibson, Wenqi Li, Carole Sudre, Lucas Fidon, Dzhoshkun I Shakir, Guotai Wang, Zach Eaton-Rosen, Robert Gray, Tom Doel, Yipeng Hu, Tom Whyntie, Parashkev Nachev, Marc Modat, Dean C Barratt, Sébastien Ourselin, M Jorge Cardoso, Tom Vercauteren
BACKGROUND AND OBJECTIVES: Medical image analysis and computer-assisted intervention problems are increasingly being addressed with deep-learning-based solutions. Established deep-learning platforms are flexible but do not provide specific functionality for medical image analysis and adapting them for this domain of application requires substantial implementation effort. Consequently, there has been substantial duplication of effort and incompatible infrastructure developed across many research groups...
May 2018: Computer Methods and Programs in Biomedicine
Anne Bernhardt, Birgit Paul, Michael Gelinsky
BACKGROUND: Collagens of marine origin are applied increasingly as alternatives to mammalian collagens in tissue engineering. The aim of the present study was to develop a biphasic scaffold from exclusively marine collagens supporting both osteogenic and chondrogenic differentiation and to find a suitable setup for in vitro chondrogenic and osteogenic differentiation of human mesenchymal stroma cells (hMSC). METHODS: Biphasic scaffolds from biomimetically mineralized salmon collagen and fibrillized jellyfish collagen were fabricated by joint freeze-drying and crosslinking...
March 13, 2018: Marine Drugs
William Sledge, Julia Rozanova, Julianne Dorset
OBJECTIVE: To provide a follow up of a 1976 study of the impact of captivity on U.S. Air Force (USAF) POWs and USAF Controls matched for time in Southeast Asia, military rank and aircraft crew position. METHOD: Qualitative study of replies to open ended questions of positive and negative changes due to their captivity/combat experiences made by participants (POWs and Controls) who replied in both 1976 and in 2003. RESULTS: Both groups acknowledged positive and negative effects of the experiences in 1976...
March 13, 2018: Psychiatry
Yijun Lin, Dimitrios Stripelis, Yao-Yi Chiang, José Luis Ambite, Rima Habre, Fan Pan, Sandrah P Eckel
Air quality models are important for studying the impact of air pollutant on health conditions at a fine spatiotemporal scale. Existing work typically relies on area-specific, expert-selected attributes of pollution emissions (e,g., transportation) and dispersion (e.g., meteorology) for building the model for each combination of study areas, pollutant types, and spatiotemporal scales. In this paper, we present a data mining approach that utilizes publicly available OpenStreetMap (OSM) data to automatically generate an air quality model for the concentrations of fine particulate matter less than 2...
November 2017: Proceedings of the ... ACM SIGSPATIAL International Conference on Advances in Geographic Information Systems: ACM GIS
Neil Bodagh, R Andrew Archbold, Roshan Weerackody, Meredith K D Hawking, Michael R Barnes, Aaron M Lee, Surjeet Janjuha, Charles Gutteridge, John Robson, Adam Timmis
OBJECTIVES: The electronic health record (EHR) is underused in the hospital setting. The aim of this service evaluation study was to respond to National Health Service (NHS) Digital's ambition for a paperless NHS by capturing routinely collected cardiac outpatient data in the EHR to populate summary patient reports and provide a resource for audit and research. DESIGN: A PowerForm template was developed within the Cerner EHR, for real-time entry of routine clinical data by clinicians attending a cardiac outpatient clinic...
March 8, 2018: BMJ Open
María José Fernández-Megía, Isabel Font Noguera, Matilde Merino Sanjuán, José Luis Poveda Andrés
OBJECTIVE: To analyze the results of sentinel patient program to monitoring the  quality pharmacoterapeutic process in the hospitalized patient through  medication errors. METHOD: Design: Observational, prospective and transversal study. Ambit: General hospital of 1,000 beds. PERIOD: From May 2011 to June 2016.  Sample: Patients with treatment prescribe within 24 hours of being admitted  with 4 or more medications. VARIABLES: Medication error, drugs prescribed,  medications and doses dispensing, drugs administered...
March 1, 2018: Farmacia Hospitalaria
Sally C Davies
Antibiotics are indispensable for treating bacterial infections, but their effectiveness is threatened by the emergence and spread of antibacterial resistance. Antibiotics are unique among drugs since the more they are used, the less effective they become because bacterial resistance is likely to develop. In response to this threat, the UK government aims to reduce inappropriate antibiotic prescribing in humans by 50% by 2020. A team at Public Health England has found that at least 20% of antibiotic prescriptions in primary care in England were inappropriate, which, if correct, implies that antibiotic prescribing nationally needs to be reduced by 10% by 2020...
February 27, 2018: Journal of Antimicrobial Chemotherapy
Hanns Lochmüller, Dorota M Badowska, Rachel Thompson, Nine V Knoers, Annemieke Aartsma-Rus, Ivo Gut, Libby Wood, Tina Harmuth, Andre Durudas, Holm Graessner, Franz Schaefer, Olaf Riess
Although individually uncommon, rare diseases (RDs) collectively affect 6-8% of the population. The unmet need of the rare disease community was recognized by the European Commission which in 2012 funded three flagship projects, RD-Connect, NeurOmics, and EURenOmics, to help move the field forward with the ambition of advancing -omics research and data sharing at their core in line with the goals of IRDiRC (International Rare Disease Research Consortium). NeurOmics and EURenOmics generate -omics data and improve diagnosis and therapy in rare renal and neurological diseases, with RD-Connect developing an infrastructure to facilitate the sharing, systematic integration and analysis of these data...
February 27, 2018: European Journal of Human Genetics: EJHG
Delphine Destoumieux-Garzón, Patrick Mavingui, Gilles Boetsch, Jérôme Boissier, Frédéric Darriet, Priscilla Duboz, Clémentine Fritsch, Patrick Giraudoux, Frédérique Le Roux, Serge Morand, Christine Paillard, Dominique Pontier, Cédric Sueur, Yann Voituron
Over the past decade, a significant increase in the circulation of infectious agents was observed. With the spread and emergence of epizootics, zoonoses, and epidemics, the risks of pandemics became more and more critical. Human and animal health has also been threatened by antimicrobial resistance, environmental pollution, and the development of multifactorial and chronic diseases. This highlighted the increasing globalization of health risks and the importance of the human-animal-ecosystem interface in the evolution and emergence of pathogens...
2018: Frontiers in Veterinary Science
Elina Lämsä, Johanna Timonen, Riitta Ahonen
BACKGROUND: One of the forerunners in electronic health, Finland has introduced electronic prescriptions (ePrescriptions) nationwide by law. This has led to significant changes for pharmacy customers. Despite the worldwide ambition to develop ePrescription services, there are few reports of nationally adopted systems and particularly on the experiences of pharmacy customers. OBJECTIVE: The aim of this study was to investigate Finnish pharmacy customers' (1) experiences with purchasing medicines with ePrescriptions; (2) experiences with renewing ePrescriptions and acting on behalf of someone else at the pharmacy; (3) ways in which customers keep up to date with their ePrescriptions; and (4) overall satisfaction with ePrescriptions...
February 23, 2018: Journal of Medical Internet Research
James Pickett, Cathy Bird, Clive Ballard, Sube Banerjee, Carol Brayne, Katherine Cowan, Linda Clare, Adelina Comas-Herrera, Lynne Corner, Stephanie Daley, Martin Knapp, Louise Lafortune, Gill Livingston, Jill Manthorpe, Natalie Marchant, Jo Moriarty, Louise Robinson, Clare van Lynden, Gill Windle, Bob Woods, Katherine Gray, Clare Walton
OBJECTIVE: National and global dementia plans have focused on the research ambition to develop a cure or disease-modifying therapy by 2025, with the initial focus on investment in drug discovery approaches. We set out to develop complementary research ambitions in the areas of prevention, diagnosis, intervention, and care and strategies for achieving them. METHODS: Alzheimer's Society facilitated a taskforce of leading UK clinicians and researchers in dementia, UK funders of dementia research, people with dementia, and carer representatives to develop, using iterative consensus methodology, goals and recommendations to advance dementia research...
February 22, 2018: International Journal of Geriatric Psychiatry
Jaspreet Singh Sangha Brar, Saurav Gupta, Salahudeen M Haja Mohideen, Lishya Liauw, Narayan Lath
The association between immunoglobulin IgG4 and autoimmune pancreatitis was first shown in 2001. Since then many previously established fibrosclerotic diseases demonstrating synchronous or metachronous multiorgan involvement have been included within the ambit of IgG4-related disease. Diagnostic criteria have been proposed involving 1) serum IgG4 level elevated beyond 135 mg/dL, 2) IgG4+ to IgG+ plasma cell ratio >40% and >10 IgG4+ cells per high power field of biopsy sample and 3) a constellation of imaging features which involve a variety of organ systems...
February 21, 2018: Diagnostic and Interventional Radiology: Official Journal of the Turkish Society of Radiology
Raeanne C Moore, Mariam A Hussain, Caitlin W-M Watson, Pariya L Fazeli, María J Marquine, Brandon C Yarns, Dilip V Jeste, David J Moore
Grit and ambition are psychological factors that may protect neurocognitive function among persons living with HIV (PLWH). We examined associations between grit, ambition, premorbid verbal intellectual function, and current neurocognitive and everyday functioning among PLWH and persons without HIV (HIV-). 120 PLWH and 94 HIV- adults completed the Grit Scale (includes total score and consistency of interests and perseverance of effort subscales), ambition scale, and a comprehensive neurobehavioral battery. PLWH had lower grit scores than HIV- adults...
February 17, 2018: AIDS and Behavior
Caroline Elizabeth Pearson, Allan J Butler, Yaqub Paul Murray
The Vet Futures Report has identified 'exceptional leadership' as a key ambition for the long-term sustainability of the industry. This research investigates what it is like to be a veterinary surgeon in an in-practice leadership position, applying the qualitative methodology of interpretative phenomenological analysis. Through the researchers' interpretation of the seven participants' stories of their leadership experiences, the study advances understanding of the work environment, underlying motivations and the perceived responsibilities of veterinary leaders...
February 14, 2018: Veterinary Record
M Barbateskovic, S R Kraus, M O Collet, O Mathiesen, J C Jakobsen, A Perner, J Wetterslev
BACKGROUND: In the intensive care unit, the prevalence of delirium is high. Delirium has been associated with morbidity and mortality including more ventilator days, longer intensive care unit stay, increased long-term mortality, and cognitive impairment. Thus, the burden of delirium for patients, relatives, and societies is considerable. The objective of this systematic review was to critically access the evidence of randomised clinical trials on the effects of haloperidol vs. placebo or any other agents for delirium in critically ill patients...
February 14, 2018: Acta Anaesthesiologica Scandinavica
Flynn Murphy
No abstract text is available yet for this article.
February 9, 2018: BMJ: British Medical Journal
Charles D Burger, A Burak Ozbay, Howard M Lazarus, Ellen Riehle, Leslie B Montejano, Gregory Lenhart, R James White
BACKGROUND: Despite multiple treatment options, the prognosis of pulmonary arterial hypertension (PAH) remains poor. PAH patients experience a high economic burden due to comorbidities, hospitalizations, and medication costs. Although combination therapy has been shown to reduce hospitalizations, the relationship between treatment, health care utilization, and costs remains unclear. OBJECTIVE: To provide a characterization of health care utilization and costs in real-world settings by comparing periods before and after initiating PAH-specific treatment...
February 13, 2018: Journal of Managed Care & Specialty Pharmacy
Stefania Benvenuti, Virginia Brighenti, Federica Pellati
Anthocyanins represent the most abundant class of bioactive compounds present in Vaccinium myrtillus L. (bilberry) fruit, conferring it several health-promoting properties. The content of anthocyanins in food products produced from bilberries can be affected by many parameters, making the study of their composition a critical issue. In this ambit, this work was aimed at a comprehensive profiling of anthocyanins in bilberry fruit and derivatives from the Italian Northern Apennines, including jam, juice, and liqueur ("Mirtillino")...
February 10, 2018: Analytical and Bioanalytical Chemistry
Charles Bodar, Job Spijker, Johannes Lijzen, Susanne Waaijers-van der Loop, Richard Luit, Evelyn Heugens, Martien Janssen, Pim Wassenaar, Theo Traas
The ambitions for a circular economy are high and unambiguous, but day-to-day experience shows that the transition still has many difficulties to overcome. One of the current hurdles is the presence of hazardous substances in waste streams that enter or re-enter into the environment or the technosphere. The key question is: do we have the appropriate risk management tools to control any risks that might arise from the re-using and recycling of materials? We present some recent cases that illustrate current practice and complexity in the risk management of newly-formed circular economy chains...
February 8, 2018: Journal of Environmental Management
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