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https://www.readbyqxmd.com/read/28538712/comment-programmed-to-fulfill-global-ambitions
#1
Wang Qi
No abstract text is available yet for this article.
May 24, 2017: Nature
https://www.readbyqxmd.com/read/28511937/hot-start-to-european-pluripotent-stem-cell-banking
#2
Paul A De Sousa, Rachel Steeg, Beate Kreisel, Timothy E Allsopp
Achieving consistency in standards of access to and quality of human induced pluripotent stem cells has lagged behind their use. In Europe, a network of academic and industrial partners has been established to overcome this challenge. The experience reveals the devil in the detail of worthy ambitions informing future efforts.
May 13, 2017: Trends in Biotechnology
https://www.readbyqxmd.com/read/28508957/genetic-and-environmental-correlations-between-subjective-wellbeing-and-experience-of-life-events-in-adolescence
#3
Robyn E Wootton, Oliver S P Davis, Abigail L Mottershaw, R Adele H Wang, Claire M A Haworth
Some life events appear heritable due to the genetic influence on related behaviours. Shared genetic influence between negative behaviours and negative life events has previously been established. This study investigated whether subjective wellbeing and positive life events were genetically associated. Participants in the Twins Early Development Study (aged 16.32 ± .68 years) completed subjective wellbeing and life events assessments via two separate studies (overlapping N for wellbeing and life events measures ranged from 3527 to 9350)...
May 16, 2017: European Child & Adolescent Psychiatry
https://www.readbyqxmd.com/read/28497502/improving-outcome-of-fungal-diseases-guiding-experts-and-patients-towards-excellence
#4
Oliver A Cornely, Cornelia Lass-Flörl, Katrien Lagrou, Valentina Arsic-Arsenijevic, Martin Hoenigl
Invasive fungal infections are on the rise and during recent years understanding the epidemiology of fungal infections improved. Over 1 billion people are affected and 25 million patients are at imminent risk of severe organ damage or death due to fungal infection. The European Confederation of Medical Mycology (ECMM), founded in 1993, is the roof organisation of 23 National Medical Mycology Societies in Europe. ECMM fights fungal infections at various levels, by creating and distributing scientific knowledge and promoting scientific exchange...
May 12, 2017: Mycoses
https://www.readbyqxmd.com/read/28495977/modelling-the-implications-of-reducing-smoking-prevalence-the-public-health-and-economic-benefits-of-achieving-a-tobacco-free-uk
#5
Daniel Hunt, André Knuchel-Takano, Abbygail Jaccard, Arti Bhimjiyani, Lise Retat, Chit Selvarajah, Katrina Brown, Laura L Webber, Martin Brown
INTRODUCTION: Smoking is still the most preventable cause of cancer, and a leading cause of premature mortality and health inequalities in the UK. This study modelled the health and economic impacts of achieving a 'tobacco-free' ambition (TFA) where, by 2035, less than 5% of the population smoke tobacco across all socioeconomic groups. METHODS: A non-linear multivariate regression model was fitted to cross-sectional smoking data to create projections to 2035. These projections were used to predict the future incidence and costs of 17 smoking-related diseases using a microsimulation approach...
May 11, 2017: Tobacco Control
https://www.readbyqxmd.com/read/28494336/metabolite-profiling-of-flavonols-and-in-vitro-antioxidant-activity-of-young-shoots-of-wild-humulus-lupulus-l-hop
#6
Annalisa Maietti, Virginia Brighenti, Gianpiero Bonetti, Paola Tedeschi, Francesco Pio Prencipe, Stefania Benvenuti, Vincenzo Brandolini, Federica Pellati
Humulus lupulus L., commonly named hop, is well-known for its sedative and estrogenic activity. While hop cones are widely characterized, only few works have been carried out on the young shoots of this plant. In the light of this, the aim of this study was to identify for the first time the flavonoids present in young hop shoots and to compare the composition of samples harvested from different locations in Northern Italy with their antioxidant activity. The samples were extracted by means of dynamic maceration with methanol...
April 29, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28479802/treatment-discontinuation-in-schizophrenia-a-qualitative-exploration-from-a-rural-south-indian-community
#7
K Shanivaram Reddy, Jagadisha Thirthalli, C Naveen Kumar, N Krishna Reddy, Somashekar Bijjal, N R Renuka Devi, Vikram Singh Rawat
BACKGROUND: Medication discontinuation remains a big hurdle for retaining persons with schizophrenia under the treatment AMBIT. It is imperative to understand reasons for the same to effectively tackle it. METHODS: The study was carried out in Turuvekere, a rural South Indian taluk (an administrative block). Qualitative interviews were conducted with consenting consecutive nineteen patients (along with their family members) who had discontinued medications. All interviews were transcribed...
April 2017: Journal of Neurosciences in Rural Practice
https://www.readbyqxmd.com/read/28474585/introduction-of-new-vaccines-in-state-immunization-schedule-delhi-s-experience
#8
Amita Raoot, Dharmendra Kumar Dewan, A P Dubey, Suresh Seth
Immunization is an established, cost-effective, preventive intervention to improve child survival. To provide protection against vaccine preventable diseases, all countries in the world have an immunization program that offers selected vaccines to the eligible beneficiaries. In India, Expanded Program of Immunization was started in 1978, and then Universal Immunization Program was launched in 1985 with six antigens. This article describes the experience with institutionalization of four state-specific vaccines by Delhi in its immunization schedule to enlarge the ambit of immunization services...
April 15, 2017: Indian Pediatrics
https://www.readbyqxmd.com/read/28474121/optimal-nutrition-and-the-ever-changing-dietary-landscape-a-conference-report
#9
A Shao, A Drewnowski, D C Willcox, L Krämer, C Lausted, M Eggersdorfer, J Mathers, J D Bell, R K Randolph, R Witkamp, J C Griffiths
The field of nutrition has evolved rapidly over the past century. Nutrition scientists and policy makers in the developed world have shifted the focus of their efforts from dealing with diseases of overt nutrient deficiency to a new paradigm aimed at coping with conditions of excess-calories, sedentary lifestyles and stress. Advances in nutrition science, technology and manufacturing have largely eradicated nutrient deficiency diseases, while simultaneously facing the growing challenges of obesity, non-communicable diseases and aging...
May 5, 2017: European Journal of Nutrition
https://www.readbyqxmd.com/read/28469623/protein-delivery-into-plant-cells-toward-in-vivo-structural-biology
#10
Cesyen Cedeño, Kris Pauwels, Peter Tompa
Understanding the biologically relevant structural and functional behavior of proteins inside living plant cells is only possible through the combination of structural biology and cell biology. The state-of-the-art structural biology techniques are typically applied to molecules that are isolated from their native context. Although most experimental conditions can be easily controlled while dealing with an isolated, purified protein, a serious shortcoming of such in vitro work is that we cannot mimic the extremely complex intracellular environment in which the protein exists and functions...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28462708/collaborative-and-defensive-fibroblasts-in-tumor-progression-and-therapy-resistance
#11
Barbara Chiavarina, Andrei Turtoi
Tumor microenvironment is a complex network of epithelial cancer cells and non-transformed stromal cells. Of the many stromal cell types, fibroblasts are the most numerous ones and are traditionally viewed as supportive elements of cancer progression. Many studies show that cancer cells engage in active crosstalk with associated fibroblasts in order to obtain key resources, such as growth factors and nutrients. The facets of fibroblast "complicity to murder" in cancer are multiple. However, recent therapeutic attempts aiming at depleting fibroblasts from tumors, perturbed our rather simplistic picture...
April 27, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28460659/tuberculosis-innovations-mean-little-if-they-cannot-save-lives
#12
Madhukar Pai, Jennifer Furin
The past decade has seen the emergence of new diagnostics and drugs for tuberculosis, a disease that kills over 1.8 million people each year. However, these new tools are yet to reach scale, and access remains a major challenge for patients in low and middle income countries. Urgent action is needed if we are committed to ending the TB epidemic. This means raising the level of ambition, embracing innovation, increasing financial investments, addressing implementation gaps, and ensuring that new technologies reach those who need them to survive...
May 2, 2017: ELife
https://www.readbyqxmd.com/read/28426890/fine-mapping-of-lipid-regions-in-global-populations-discovers-ethnic-specific-signals-and-refines-previously-identified-lipid-loci
#13
Niha Zubair, Mariaelisa Graff, Jose Luis Ambite, William S Bush, Gleb Kichaev, Yingchang Lu, Ani Manichaikul, Wayne H-H Sheu, Devin Absher, Themistocles L Assimes, Suzette J Bielinski, Erwin P Bottinger, Petra Buzkova, Lee-Ming Chuang, Ren-Hua Chung, Barbara Cochran, Logan Dumitrescu, Omri Gottesman, Jeffrey W Haessler, Christopher Haiman, Gerardo Heiss, Chao A Hsiung, Yi-Jen Hung, Chii-Min Hwu, Jyh-Ming J Juang, Loic Le Marchand, I-Te Lee, Wen-Jane Lee, Li-An Lin, Danyu Lin, Shih-Yi Lin, Rachel H Mackey, Lisa W Martin, Bogdan Pasaniuc, Ulrike Peters, Irene Predazzi, Thomas Quertermous, Alex P Reiner, Jennifer Robinson, Jerome I Rotter, Kelli K Ryckman, Pamela J Schreiner, Eli Stahl, Ran Tao, Michael Y Tsai, Lindsay L Waite, Tzung-Dau Wang, Steven Buyske, Yii-Der Ida Chen, Iona Cheng, Dana C Crawford, Ruth J F Loos, Stephen S Rich, Myriam Fornage, Kari E North, Charles Kooperberg, Cara L Carty
Genome-wide association studies have identified over 150 loci associated with lipid traits, however, no large-scale studies exist for Hispanics and other minority populations. Additionally, the genetic architecture of lipid-influencing loci remains largely unknown. We performed one of the most racially/ethnically diverse fine-mapping genetic studies of HDL-C, LDL-C, and triglycerides to-date using SNPs on the MetaboChip array on 54,119 individuals: 21,304 African Americans, 19,829 Hispanic Americans, 12,456 Asians, and 530 American Indians...
December 15, 2016: Human Molecular Genetics
https://www.readbyqxmd.com/read/28425346/ambrisentan-a-review-of-its-use-in-pulmonary-arterial-hypertension
#14
Belinda N Rivera-Lebron, Michael G Risbano
Pulmonary arterial hypertension (PAH) is a progressive disease defined by an elevation in pulmonary arterial pressure that can lead to right heart failure and death. Ambrisentan is a selective endothelin receptor antagonist approved for the treatment of idiopathic, heritable PAH and connective tissue disease-associated PAH. Ambrisentan has been shown to improve exercise capacity and hemodynamics with an acceptable side-effect profile. It has also proven to be safely used in combination with other PAH-specific medications, especially with phosphodiesterase-5 inhibitors...
April 1, 2017: Therapeutic Advances in Respiratory Disease
https://www.readbyqxmd.com/read/28423792/acronym-disambiguation-in-spanish-electronic-health-narratives-using-machine-learning-techniques
#15
Ignacio Rubio-López, Roberto Costumero, Héctor Ambit, Consuelo Gonzalo-Martín, Ernestina Menasalvas, Alejandro Rodríguez González
Electronic Health Records (EHRs) are now being massively used in hospitals what has motivated current developments of new methods to process clinical narratives (unstructured data) making it possible to perform context-based searches. Current approaches to process the unstructured texts in EHRs are based in applying text mining or natural language processing (NLP) techniques over the data. In particular Named Entity Recognition (NER) is of paramount importance to retrieve specific biomedical concepts from the text providing the semantic type of the concept retrieved...
2017: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/28406202/finding-pathways-to-national-scale-land-sector-sustainability
#16
Lei Gao, Brett A Bryan
The 17 Sustainable Development Goals (SDGs) and 169 targets under Agenda 2030 of the United Nations map a coherent global sustainability ambition at a level of detail general enough to garner consensus amongst nations. However, achieving the global agenda will depend heavily on successful national-scale implementation, which requires the development of effective science-driven targets tailored to specific national contexts and supported by strong national governance. Here we assess the feasibility of achieving multiple SDG targets at the national scale for the Australian land-sector...
April 12, 2017: Nature
https://www.readbyqxmd.com/read/28383620/-integrated-project-of-personalisation-school-curricula-and-training
#17
A Zanon, R Tomassoni, N Santangelo, M Gargano, E Treglia, M G Granai, A Incagnoli
OBJECTIVES: To strengthen the motivation to study, promote awareness of their attitudes and actions of orientation / re-orientation to the profession, making the learning experience more stimulating and training in order to staunch the sharp drop-out affecting the school. MATERIALS AND METHODS: The project, coordinated by psychologists, involved the administration of AMOS Test as a tool to detect the variables of interest (self-image, ambitions and motivations, concerns for the future, soft skills etc...
March 2017: La Clinica Terapeutica
https://www.readbyqxmd.com/read/28382670/marijuana-and-alcohol-use-as-predictors-of-academic-achievement-a-longitudinal-analysis-among-youth-in-the-compass-study
#18
Karen A Patte, Wei Qian, Scott T Leatherdale
BACKGROUND: We tested the effect of initiating marijuana and alcohol use at varying frequencies on academic indices. METHODS: In a sample of 26,475 grade 9-12 students with at least 2 years of linked longitudinal data from year 1 (Y1: 2012-2013), year 2 (Y2: 2013-2014), and year 3 (Y3: 2014-2015) of the COMPASS study, separate multinomial generalized estimating equations models tested the likelihood of responses to measures of academic goals, engagement, preparedness, and performance when shifting from never using alcohol or marijuana at baseline to using them at varying frequencies at follow -up...
May 2017: Journal of School Health
https://www.readbyqxmd.com/read/28380003/cause-of-death-in-patients-with-poststroke-epilepsy-results-from-a-nationwide-cohort-study
#19
Julia Hansen, Signild Åsberg, Eva Kumlien, Johan Zelano
The risk of death is increased for persons with epilepsy. The literature on causes of death in epilepsy is based mainly on cohorts with epilepsy of mixed aetiologies. For clinical purposes and improved understanding of mortality in different epilepsies, more information is needed on mortality in epilepsies of specific causes. In poststroke epilepsy (PSE), seizures occur in a setting of vascular disease and high mortality rates. The extent to which epilepsy contributes to mortality in this patient group is poorly understood...
2017: PloS One
https://www.readbyqxmd.com/read/28375501/seven-ethical-issues-affecting-neurosurgeons-in-the-context-of-health-care-reform
#20
T Forcht Dagi
Ethical discussions around health care reform typically focus on problems of social justice and health care equity. This review, in contrast, focuses on ethical issues of particular importance to neurosurgeons, especially with respect to potential changes in the physician-patient relationship that may occur in the context of health care reform.The Patient Protection and Affordable Care Act (ACA) of 2010 (H.R. 3590) was not the first attempt at health care reform in the United States but it is the one currently in force...
April 1, 2017: Neurosurgery
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