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Volker Wenzel, Nikolaus Gravenstein
PURPOSE OF REVIEW: Mentoring is fundamentally valuable and important to students considering a path into our specialty, as well as to colleagues already in it and with ambition to advance. General principles and personal experiences are collected and described to help inform future mentors and to reinforce the value of having a mentor and the satisfaction (and work) that is associated with such a role. RECENT FINDINGS: Detecting a latent talent among medical students or residents may be challenging but is worth the effort to develop personal careers and the specialty itself...
October 18, 2016: Current Opinion in Anaesthesiology
Cees van Kooten, Ton J Rabelink, Johan W de Fijter, Marlies E J Reinders
PURPOSE OF REVIEW: Progress in the improvement of short-term and long-term outcomes of kidney transplantation seems to have reached a plateau, partially due to consequences of very efficient, but nonspecific immunosuppressive drugs. In recent years, various forms of cell therapy, including the use of mesenchymal stromal cells, have been put forward as an alternative strategy for more defined therapy. It is thought that these therapies will not only allow controlled tapering of immunosuppressive medication, but might bring us also closer to the ambition of generating donor-specific immune regulation and tolerance...
October 15, 2016: Current Opinion in Organ Transplantation
Loretta Pobłocka-Olech, Daniel Głód, Maria E Żebrowska, Małgorzata Sznitowska, Miroslawa Krauze-Baranowska
This study comprises the optimization and validation of a new TLC method for determination of flavonols in the bulbs of seven cultivars of onions and shallots. Separation was performed on RP-18 plates with the solvent mixture tetrahydrofuran/water/formic acid (40+60+6, V/V/V) as a mobile phase. The method was evaluated for precision, linearity, LOD, LOQ, accuracy and robustness. Chromatographic analysis of the extracts revealed the presence of three main flavonols, quercetin, quercetin-4'-O-glucoside and quercetin-3,4'-O-diglucoside in the majority of analyzed cultivars...
December 1, 2016: Acta Pharmaceutica
Marius M Hoeper, Vallerie V McLaughlin, Joan Albert Barberá, Adaani E Frost, Hossein-Ardeschir Ghofrani, Andrew J Peacock, Gérald Simonneau, Stephan Rosenkranz, Ronald J Oudiz, R James White, Karen L Miller, Jonathan Langley, Julia H N Harris, Christiana Blair, Lewis J Rubin, Jean-Luc Vachiery
BACKGROUND: In treatment-naive patients with pulmonary arterial hypertension, initial combination therapy with ambrisentan and tadalafil reduces the risk of clinical failure events compared with monotherapy. We did this secondary analysis to further investigate the effect of combination therapy on survival. METHODS: We analysed survival data from the modified intention-to-treat population of the Ambrisentan and Tadalafil in Patients with Pulmonary Arterial Hypertension (AMBITION) trial...
October 10, 2016: Lancet Respiratory Medicine
Jennifer Fang, Kelley Lee, Nidhi Sejpal
The China National Tobacco Corporation (CNTC), which produces one-third of the world's cigarettes, is the largest tobacco company in the world. Over the past 60 years, the CNTC has been focused on supplying a huge domestic market. As the market has become increasingly saturated, and potential foreign competition looms, the company has turned to expansion abroad. This paper examines the ambitions and prospects of the CNTC to 'go global'. Using Chinese and English language sources, this paper describes the globalisation ambitions of the CNTC, and its global business strategy focused on internal restructuring, brand development and expansion of overseas operations in selected markets...
October 13, 2016: Global Public Health
Lydie Ryšavá, Jaroslav Kříž, Lucie Kašparová, Tereza Křížová, Monika Žoltá, Petra Lisníková
Monitoring of Ioduria and Iodine saturation are essential tools for evaluation of effectivness of measures aimed at elimination of diseases caused by iodine deficiency. Between 1995 and 2016 monitoring of ioduria was udertaken in various population groups in Czech Republic. The most recent study (2015) found only 37 % of pregnant women in optimal range of ioduria (150-300 mcg/l), in iodopenic range 27 %, while 6 % of these had severe iodopenia below 50 mcg/l. In a group of 3y old children investigated in the same year, 57 % were found to have Ioduria within the recommended range (90-299 mcg/l), 24 % had higher than recommended Ioduria (300-499 mcg/l) and 8 % excessive saturation (over 500 mcg/l)...
2016: Vnitr̆ní Lékar̆ství
Ines Ambite, Manoj Puthia, Karoly Nagy, Caterina Cafaro, Aftab Nadeem, Daniel S C Butler, Gustav Rydström, Nina A Filenko, Björn Wullt, Thomas Miethke, Catharina Svanborg
The clinical studies were approved by the Human Ethics Committee at Lund University (approval numbers LU106-02, LU236-99 and Clinical Trial Registration RTP-A2003, International Committee of Medical Journal Editors,
October 2016: PLoS Pathogens
Vincenzo N Talesa, Ivana Ferri, Guido Bellezza, Harold D Love, Angelo Sidoni, Cinzia Antognelli
BACKGROUND: Glyoxalase 2 (Glo2), together with glyoxalase 1 (Glo1), forms the main scavenging system of methylglyoxal, a potent pro-apoptotic agent mainly generated by glycolysis. An increased rate of glycolysis is a well known signature of cancer cells. As a survival strategy, Glo1 is overexpressed in many human malignant cells, including prostate cancer (PCa), where it plays a crucial role in progression. No information is available on the role of Glo2 in the same ambit. PCa is the most common malignancy affecting men in the western world...
October 3, 2016: Prostate
Janine O'Flynn
Many public policy programs fail to translate ambitious headlines to on-the-ground action. The reasons for this are many and varied, but for public administration and management scholars a large part of the gap between ambition and achievement is the challenge associated with the operation of the machinery of government itself, and how it relates to the other parties that it relies on to fulfill these outcomes. In their article, Carey and Friel set out key reasons why public health scholars should seek to better understand important ideas in public administration...
April 30, 2016: International Journal of Health Policy and Management
S Loland, Mike McNamee
The European College of Sport Science (ECSS) was established in part to promote the integrated study of sports and related phenomena from multi- and interdisciplinary perspectives. There are significant and enduring philosophical, epistemological and professional challenges and opportunities that arise from this integrationist perspective. In this article, we reflect upon the challenges that have arisen in the development of sport sciences in the attempt to realize the ECSS mission. We identify three paradigmatic approaches to sports science: (1) the mechanistic; (2) the hermeneutic and (3) the critical...
August 16, 2016: European Journal of Sport Science
(no author information available yet)
No abstract text is available yet for this article.
2016: Nature
Michael Obersteiner, Brian Walsh, Stefan Frank, Petr Havlík, Matthew Cantele, Junguo Liu, Amanda Palazzo, Mario Herrero, Yonglong Lu, Aline Mosnier, Hugo Valin, Keywan Riahi, Florian Kraxner, Steffen Fritz, Detlef van Vuuren
The 17 Sustainable Development Goals (SDGs) call for a comprehensive new approach to development rooted in planetary boundaries, equity, and inclusivity. The wide scope of the SDGs will necessitate unprecedented integration of siloed policy portfolios to work at international, regional, and national levels toward multiple goals and mitigate the conflicts that arise from competing resource demands. In this analysis, we adopt a comprehensive modeling approach to understand how coherent policy combinations can manage trade-offs among environmental conservation initiatives and food prices...
September 2016: Science Advances
Luca Sala, Milena Bellin, Christine L Mummery
Cardiotoxicity is a severe side effect of drugs that induce structural or electrophysiological changes in heart muscle cells. As a result, the heart undergoes failure and potentially lethal arrhythmias. It is still a major reason for drug failure in preclinical and clinical phases of drug discovery. Current methods for predicting cardiotoxicity are based on guidelines which combine electrophysiological analysis of cell lines expressing ion channels ectopically in vitro with animal models and clinical trials...
September 19, 2016: British Journal of Pharmacology
Troels Ring, John A Kellum
Understanding acid-base regulation is often reduced to pigeonholing clinical states into categories of disorders based on arterial blood sampling. An earlier ambition to quantitatively explain disorders by measuring production and elimination of acid has not become standard clinical practice. Seeking back to classical physical chemistry we propose that in any compartment, the requirement of electroneutrality leads to a strong relationship between charged moieties. This relationship is derived in the form of a general equation stating charge balance, making it possible to calculate [H+] and pH based on all other charged moieties...
2016: PloS One
Ines Ambite, Gustav Rydstrom, Andrew L Schwaderer, David S Hains
The urinary tract is a sterile organ system. Urinary tract infections (UTIs) are common and often serious infections. Research has focused on uropathogen, environment, and host factors leading to UTI pathogenesis. A growing body of evidence exists implicating genetic factors that can contribute to UTI risks. In this review, we highlight genetic variations in aspects of the innate immune system critical to the host response to uropathogens. This overview includes genetic variations in pattern recognition receptor molecules, chemokines/cytokines, and neutrophil activation...
March 2016: Journal of Pediatric Genetics
Michael Shulman
Analysts have often described their work as depriving, painful, and hard to endure, while its pleasures have been the subject of little commentary. The real history and ongoing temptations of boundary violation long ago made the gratifications of psychoanalytic work a matter of anxiety. Analysts' pleasure in their work was problematized. Some of this problematizing is necessary because of real risk, but much of it is not only unnecessary but misleading and destructive. Psychoanalysts pursue achievement of a unique form of human intimacy, yet acquired habits of professional modesty and humility have encouraged the illusion that analyzing can occur without desire or ambition on the analyst's part...
August 2016: Journal of the American Psychoanalytic Association
Ruth Macklin
In his excellent article about commercial conflict of interest, Mark Wilson quotes Dennis Thompson, a political scientist who provided a searching analysis of the concept of conflict of interest (Col). Using Thompson's analysis, Wilson writes: "Determining whether factors such as ambition, the pursuit of fame and financial gain had biased a judgment was challenging. Motives are not always clear to either the conflicted party or to an outside observer." In this commentary, I aim to broaden the discussion beyond the narrowly commercial aspects of Col...
October 2016: Indian Journal of Medical Ethics
Elizabeth Pisani, Maarten Olivier Kok, Kharisma Nugroho
In 2013 Indonesia, the world's fourth most populous country, declared that it would provide affordable health care for all its citizens within seven years. This crystallised an ambition first enshrined in law over five decades earlier, but never previously realised. This paper explores Indonesia's journey towards universal health coverage (UHC) from independence to the launch of a comprehensive health insurance scheme in January 2014. We find that Indonesia's path has been determined largely by domestic political concerns - different groups obtained access to healthcare as their socio-political importance grew...
September 6, 2016: Health Policy and Planning
Charlotte Bevan
Extract: Growing up, I never understood why so many people professed to have no interest in science. How could understanding how things work not be the most fascinating thing? And how we, as organisms, develop and function (or fail to) seemed to me the most fascinating thing of all. One of my most inspiring school teachers was the head of Biology and 6th-form, Dr Chris Haworth, who undertook to nurture my ambition to gain a place at "Oxbridge" (no-one from our comprehensive school in the far north of England had previously gone to either Cambridge or Oxford)...
September 6, 2016: Endocrine-related Cancer
Ronald P Rubin
While scientists were always cognizant of the fact that they must be objective about the questions they ask of nature, there was a time when they were less willing to consider the diverse views that could be contributed by female participation. Undervalued in terms of their intellect, ambition, and curiosity, women found it difficult to compete for and/or retain a research post, particularly when they married. As a result, many women undaunted by existing convention had to work without remuneration or were financially supported by colleagues and/ or relatives...
August 2016: Acta Medico-historica Adriatica: AMHA
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