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https://www.readbyqxmd.com/read/29684723/dual-role-of-the-serine-protease-homolog-bmsph-1-in-the-development-and-immunity-of-the-silkworm-bombyx-mori
#1
Kwang Sik Lee, Bo Yeon Kim, Young Moo Choo, Byung Rae Jin
Serine proteases and serine protease homologs are involved in the prophenoloxidase (proPO)-activating system leading to melanization. The Bombyx mori serine protease homolog BmSPH-1 regulates nodule melanization. Here, we show the dual role of BmSPH-1 in the development and immunity of B. mori. BmSPH-1 was expressed in hemocytes after molting and during the larval-pupal transformation in normal development. In contrast, following infection, BmSPH-1 was expressed in hemocytes and cleaved in the hemolymph, which resulted in the induction of PO activity...
April 11, 2018: Developmental and Comparative Immunology
https://www.readbyqxmd.com/read/29684704/nitrate-mediated-control-of-root-nodule-symbiosis
#2
REVIEW
Hanna Nishida, Takuya Suzaki
Nitrogen is an indispensable inorganic nutrient that is required by plants throughout their life. Root nodule symbiosis (RNS) is an important strategy mainly adopted by legumes to enhance nitrogen acquisition, where several key processes required for the establishment of the symbiosis, are pleiotropically controlled by nitrate availability in soil. Although the autoregulation of nodulation (AON), a systemic long-range signaling, has been suggested to be implicated in nitrate-induced control of RNS, AON alone is insufficient to fully explain the pleiotropic regulation that is induced by nitrate...
April 20, 2018: Current Opinion in Plant Biology
https://www.readbyqxmd.com/read/29684254/frequencies-and-malignancy-rates-of-6-tiered-bethesda-categories-of-thyroid-nodules-according-to-ultrasound-assessment-and-nodule-size
#3
Vivian Youngjean Park, Hye Sun Lee, Eun-Kyung Kim, Jin Young Kwak, Jung Hyun Yoon, Hee Jung Moon
BACKGROUND: The malignancy risk of thyroid nodules differs according to Bethesda category, ultrasound features, and nodule size. METHODS: In 2725 thyroid nodules that underwent ultrasound-guided fine-needle aspiration, frequencies and malignancy rates of Bethesda categories were compared according to size and ultrasound assessment. RESULTS: When comparing the ultrasound suspicious nodules ≤10 mm and >10 mm, the frequency of the benign cytology was statistically higher in the >10 mm group, whereas the nondiagnostic and suspicious for malignancy cytology were higher in the ≤10 mm group...
April 23, 2018: Head & Neck
https://www.readbyqxmd.com/read/29684251/image-guided-chemical-and-thermal-ablations-for-thyroid-disease-review-of-efficacy-and-complications
#4
REVIEW
Iain J Nixon, Peter Angelos, Ashok R Shaha, Alessandra Rinaldo, Michelle D Williams, Alfio Ferlito
Image-guided ablation of thyroid disease is increasingly being commonly reported. Techniques including ethanol injection and thermal ablation using radio-frequency, laser, and microwave devices have been described. Minimally invasive approaches to the management of benign cystic, solid, and functional thyroid nodules as well as both primary and recurrent thyroid malignancy have been reported. The purpose of this article is to review the current evidence relating to image-guided ablation of thyroid disease with a focus on clinical outcomes and complication rates for patients treated with this minimally invasive approach...
April 23, 2018: Head & Neck
https://www.readbyqxmd.com/read/29683969/diagnostic-accuracy-of-preoperative-imaging-for-differentiation-of-branch-duct-versus-mixed-duct-intraductal-papillary-mucinous-neoplasms
#5
Emmanuel E Ugbarugba, Carmen Grieco, Phil A Hart, Feng Li, Brett Sklaw, Kevin Cronley, Veeral M Oza, Benjamin J Swanson, Jon P Walker, Samer El-Dika, Darwin L Conwell, Somashekar G Krishna
OBJECTIVE: The aim of this study is to determine the diagnostic accuracy of preoperative evaluation to detect main pancreatic duct involvement in pancreatic cystic lesions thus differentiating mixed intraductal papillary mucinous neoplasm (IPMN) from branch duct (BD)-IPMN. METHODS: The pathology database of pancreatic resections from 2000 to 2014 was reviewed. Main pancreatic duct-IPMNs and IPMNs with intracystic mass/nodules were excluded. The preoperative test characteristics were analyzed using surgical histopathology as the "gold standard...
April 19, 2018: Pancreas
https://www.readbyqxmd.com/read/29683931/value-of-18f-fdg-pet-ct-imaging-in-the-staging-restaging-monitoring-of-response-to-therapy-and-surveillance-of-uterine-leiomyosarcomas
#6
Ophélie Bélissant, Laurence Champion, Hind Thevenet, Pierre Weinmann, Jean-Louis Alberini
OBJECTIVE: Leiomyosarcoma (LMS) is the most common subtype of uterine sarcomas. It is a rare and aggressive tumour. The aim of the present study was to assess the performance of fluorine-18-fluorodeoxyglucose (F-FDG) PET/CT imaging in four clinical settings: initial staging, restaging, monitoring of response to therapy and post-therapy surveillance of uterine LMS. PATIENTS AND METHODS: A bicentric retrospective study was carried out on a group of 21 patients with uterine LMS for whom a total of 52 PET/CT scans were available in initial staging (n=11), restaging (n=11), monitoring of response to therapy (n=17) and post-therapy surveillance (n=13)...
April 20, 2018: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/29683529/morphology-combined-with-ancillary-techniques-an-algorithm-approach-for-thyroid-nodules
#7
Esther Diana Rossi, Maurizio Martini, Sara Capodimonti, Tonia Cenci, Mirna Bilotta, Francesco Pierconti, Alfredo Pontecorvi, Celestino Pio Lombardi, Guido Fadda, Luigi Maria Larocca
OBJECTIVE: Several authors have underlined the limits of morphological analysis mostly in the diagnosis of follicular neoplasms (FN). The application of ancillary techniques (AT), including immunocytochemistry(ICC) and molecular testing (MT), contributes to a better definition of the risk of malignancy(ROM) and management of FN. According to literature, the application of models, including the evaluation of ICC, somatic mutations (i.e. BRAFV 600E ), miRNA analysis is proposed for FNs...
April 23, 2018: Cytopathology: Official Journal of the British Society for Clinical Cytology
https://www.readbyqxmd.com/read/29683022/transarterial-chemoembolization-plus-multi-imaging-guided-radiofrequency-ablation-for-elimination-of-hepatocellular-carcinoma-nodules-measuring-3-1-to-5-0-cm-a-single-center-study
#8
Wang Haochen, Wang Jian, Song Li, Lv Tianshi, Tong Xiaoqiang, Zou Yinghua
Objective This study was performed to determine whether transarterial chemoembolization (TACE) plus multi-imaging-guided radiofrequency ablation (MIG-RFA) can completely eliminate 3.1- to 5.0-cm hepatocellular carcinoma (HCC) nodules and identify factors that may influence the complete elimination rate (CER) of this therapy. Methods Patients who underwent TACE+MIG-RFA for initial treatment of HCC from January 2008 to January 2016 were retrospectively reviewed. In total, 162 patients with 216 HCC nodules (3...
January 1, 2018: Journal of International Medical Research
https://www.readbyqxmd.com/read/29682391/a-case-of-prostatic-carcinoma-manifesting-as-cutaneous-facial-nodule
#9
Israel Antonio Esquivel-Pinto, Bertha Torres-Alvarez, Ramiro Jetzabel Gómez-Villa, Juan Pablo Castanedo-Cázares
Prostate cancer is the second most frequently diagnosed cancer worldwide and the fifth most common cause of cancer deaths among men. Cutaneous metastasis is an uncommon phenomenon in prostatic cancer, occurring in 0.06-0.3% of cases. Case Presentation. A 56-year-old man presented to our outpatient clinic with a one-month history of a 1.5 cm in diameter, solitary, asymptomatic, purple nodule located on his upper right cheek. After biopsy, prostatic cancer metastasis was diagnosed. Discussion. A literature review revealed 59 articles documenting 71 cases of this diagnosis...
2018: Case Reports in Urology
https://www.readbyqxmd.com/read/29682290/british-thoracic-society-quality-standards-for-the-investigation-and-management-of-pulmonary-nodules
#10
David Baldwin, Matthew Callister, Ahsan Akram, Paul Cane, Jeanette Draffan, Kevin Franks, Fergus Gleeson, Richard Graham, Puneet Malhotra, Philip Pearson, Manil Subesinghe, David Waller, Ian Woolhouse
Introduction: The purpose of the quality standards document is to provide healthcare professionals, commissioners, service providers and patients with a guide to standards of care that should be met for the investigation and management of pulmonary nodules in the UK, together with measurable markers of good practice. Methods: Development of British Thoracic Society (BTS) Quality Standards follows the BTS process of quality standard production based on the National Institute for Health and Care Excellence process manual for the development of quality standards...
2018: BMJ Open Respiratory Research
https://www.readbyqxmd.com/read/29682139/pulmonary-epithelioid-angiosarcoma-responsive-to-chemotherapy-a-case-report
#11
Lora Shirey, Demetrius Coombs, Aditya Talwar, Timothy Mickus
Primary pulmonary epithelioid angiosarcoma (AS) is an extremely rare cancer with a poor prognosis. The presenting symptoms and imaging results are nonspecific and hold similarities with more common lung pathology, contributing to missed or delayed diagnosis. Complementing radiological imaging with patient information, such as presenting symptoms and exposures, is important for early consideration of pulmonary epithelioid AS. Even with supportive imaging findings and clinical suspicion for pulmonary epithelioid AS, the most reliable and definitive method for diagnosis is through immunohistochemistry...
April 2018: Radiology Case Reports
https://www.readbyqxmd.com/read/29682040/widespread-intra-abdominal-carcinomatosis-from-a-rhabdoid-meningioma-after-placement-of-a-ventriculoperitoneal-shunt-a-case-report-and-review-of-the-literature
#12
Jun Jie Ng, Kok Ann Teo, Asim Shabbir, Tseng Tsai Yeo
Intra-abdominal metastasis (IAM) of central nervous system (CNS) tumors through ventriculoperitoneal shunt (VPS) is rare but has been previously reported (e.g., germinomas and medulloblastomas). However, there has been no previous reports in literature involving meningiomas. A case of primary rhabdoid meningioma with widespread intra-abdominal carcinomatosis after placement of a VPS in a 36-year-old man is described. The patient underwent preoperative angioembolization of the tumor, craniotomy, and surgical excision, followed by postoperative gamma knife radiosurgery...
April 2018: Asian Journal of Neurosurgery
https://www.readbyqxmd.com/read/29681842/adult-coats-disease-presenting-as-subfoveal-nodule
#13
Salim Z Asaad, Nazimul Hussain
A 21-year-old female presented with decreased vision in the right eye. Best corrected visual acuity was 6/60 in the right eye and 6/6 in the left eye. Funduscopy of the right eye revealed a subfoveal nodule with surrounding exudates and temporal peripheral retinal vessel telangiectasia with exudation. The patient underwent retinal laser in the areas of telangiectatic vessels and capillary non-perfusion as seen on fundus fluorescein angiography. It was combined with an intravitreal injection of bevacizumab which was repeated twice at monthly intervals...
January 2018: Case Reports in Ophthalmology
https://www.readbyqxmd.com/read/29681839/long-term-follow-up-of-congenital-simple-hamartoma-of-the-retinal-pigment-epithelium-a-case-report
#14
Yuka Ito, Masahito Ohji
Background: Congenital simple hamartoma of the retinal pigment epithelium (CSHRPE) is a rare benign tumor of the retinal pigment epithelium characterized by a focal, darkly pigmented nodule in the macular lesion in healthy persons. We report a case of CSHRPE with long-term follow-up. Case: A 41-year-old Japanese woman was incidentally discovered to have a dark lesion on the fundus of the left eye. We evaluated the patient by measuring her best-corrected visual acuity (BCVA) and by slit-lamp biomicroscopy, fundus color photography, and optical coherence tomography (OCT) over a 10-year period...
January 2018: Case Reports in Ophthalmology
https://www.readbyqxmd.com/read/29681220/reactive-nodular-fibrous-pseudotumor-mimicking-metastatic-gastrointestinal-stromal-tumor-to-perigastric-lymph-node-a-case-report-and-review-of-the-literature
#15
Jinesa Moodley, Jean-Claude Cutz, Miranda Schell
Gastrointestinal stromal tumors (GIST) are the most common mesenchymal lesions of the gastrointestinal tract. Many are treated surgically with or without the use of adjuvant tyrosine kinase inhibitors. Metastases to lymph nodes are infrequent. In this article, we present a case of a perigastric nodule presenting 3 years postsurgical treatment for biopsy-proven GIST, clinically suspicious for a recurrent/metastatic GIST. The patient had also received adjuvant tyrosine kinase inhibitor therapy. Microscopic sections from the perigastric lesion showed a spindle cell nodule felt initially to represent a GIST with posttherapeutic changes...
April 1, 2018: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29680915/medullary-thyroid-carcinoma-application-of-thyroid-imaging-reporting-and-data-system-ti-rads-classification
#16
Gabin Yun, Yeo Koon Kim, Sang Il Choi, Ji-Hoon Kim
PURPOSE: To evaluate the applicability of ultrasound (US)-based Thyroid Imaging Reporting and Data System (TI-RADS) for evaluating medullary thyroid carcinoma (MTC). MATERIALS AND METHODS: US images and medical records of patients with cytopathology-confirmed MTC between June 2003 and November 2016 were retrospectively reviewed. Four independent reviewers (two experienced and two inexperienced radiologists) evaluated 57 pre-operative US images of patients with MTC for shape, composition, echogenicity, margin, calcification of the MTC nodules, and categorized the nodules using TI-RADS classification...
April 21, 2018: Endocrine
https://www.readbyqxmd.com/read/29680408/silicosis-decreases-bone-mineral-density-in-rats
#17
Zhang Hui, Xu Dingjie, Yuan Yuan, Wei Zhongqiu, Mao Na, Bei Mingjian, Gou Yu, Liu Guangyuan, Gao Xuemin, Li Shifeng, Geng Yucong, Yang Fang, Ross Summer, Xu Hong
Silicosis is the most common occupational lung disease in China, and is associated with a variety of complications, many of which are poorly understood. For example, recent data indicate that silicosis associates with the development of osteopenia, and in some cases this bone loss is severe, meeting criteria for osteoporosis. Although many factors are likely to contribute to this relationship, including a sedentary lifestyle in patients with advanced silicotic lung disease, we hypothesized that silica might directly reduce bone mineral density...
April 19, 2018: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/29679780/diagnostic-accuracy-of-mdct-in-differentiating-gallbladder-cancer-from-acute-and-xanthogranulomatous-cholecystitis
#18
Ashish P Wasnik, Mathew S Davenport, Ravi K Kaza, William J Weadock, Aaron Udager, Nahid Keshavarzi, Bin Nan, Katherine E Maturen
OBJECTIVE: To determine the diagnostic accuracy of multi-detector CT (MDCT) for differentiating gallbladder cancer from acute and xanthogranulomatous cholecystitis using previously described imaging features. METHODS: In this IRB approved HIPAA-compliant retrospective cohort study, contrast-enhanced MDCT of histologically confirmed acute cholecystitis (n = 17), xanthogranulomatous cholecystitis (n = 25), and gallbladder cancer (n = 18) were reviewed independently by three abdominal radiologists blinded to outcome...
April 14, 2018: Clinical Imaging
https://www.readbyqxmd.com/read/29679545/the-impact-of-ocular-tuberculosis-on-vision-after-two-months-of-intensive-therapy
#19
Suzana Batista Vereza de Oliveira, Ângelo Ferreira Passos, David Jamil Hadad, Lorena Zbyszynski, Pedro Sousa de Almeida Júnior, Luiz Guilherme Schmidt Castellani, Reynaldo Dietze, Moisés Palaci
Tuberculosis (TB) is an infectious disease of global importance with major economic and social burden accounting for 25% of all avoidable deaths in developing countries. Extrapulmonary involvement may occur either in association with clinically apparent pulmonary tuberculosis or in isolation. This cross-sectional descriptive study aimed to evaluate the impact of ocular tuberculosis in visual acuity at baseline and after two months of intensive anti-tuberculous therapy. A sample of 133 pulmonary TB patients, seven disseminated TB, and three pleural TB patients was evaluated...
April 18, 2018: Brazilian Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29678504/a-deadly-hidden-nodule
#20
Jo Anne Lim
No abstract text is available yet for this article.
April 17, 2018: American Journal of Obstetrics and Gynecology
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