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https://www.readbyqxmd.com/read/29475171/intrahepatic-splenosis-mimicking-hepatic-neoplasia
#1
Gabriel Neves Saad Teles, Paulo Eduardo Zerati Monteiro, Raphael Raphe
INTRODUCTION: Splenosis is defined as the heterotopic autoimplantation of splenic tissue following trauma to or surgery on the spleen. CLINICAL CASE: We present a case of an asymptomatic 73-year-old male in whom hypervascular lesions were detected during routine exams. The patient reported a history of carotid artery surgery and cholecystectomy; he had a laparotomy incision from childhood but was unaware of the reason for it. The patient exhibited slightly elevated carcinoembryonic antigen (CEA) levels...
February 17, 2018: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29474830/erythema-nodosum-leprosum-update-and-challenges-on-the-treatment-of-a-neglected-condition
#2
REVIEW
Perpétua do Socorro Silva Costa, Lucas Rosa Fraga, Thayne Woycinck Kowalski, Egon Luiz Rodrigues Daxbacher, Lavínia Schuler-Faccini, Fernanda Sales Luiz Vianna
Erythema Nodosum Leprosum (ENL) occurs due to the immunological complication of multibacillary leprosy and is characterized by painful nodules and systemic compromising. It is usually recurrent and/or chronic and has both physical and economic impact on the patient, being a very important cause of disability. In addition, ENL is a major health problem in countries where leprosy is endemic. Therefore, adequate control of this condition is important. The management of ENL aims to control acute inflammation and neuritis and prevent the onset of new episodes...
February 20, 2018: Acta Tropica
https://www.readbyqxmd.com/read/29474644/dicer1-mutations-are-frequent-in-adolescent-onset-papillary-thyroid-carcinoma
#3
Jonathan D Wasserman, Nelly Sabbaghian, Somayyeh Fahiminiya, Rose Chami, Ozgur Mete, Meryl Acker, Mona K Wu, Adam Shlien, Leanne de Kock, William D Foulkes
Context: Papillary thyroid carcinoma (PTC) is a common malignancy in adolescence and is molecularly and clinically distinct from adult PTC. Mutations in the DICER1 gene are associated with thyroid abnormalities including multinodular goitre and differentiated thyroid carcinoma. Objective: In this study, we sought to characterize the prevalence of DICER1 variants in paediatric PTC, specifically in tumours without conventional PTC oncogenic alterations. Patients: Patients (n = 40) who underwent partial or total thyroidectomy and who were <18 years of age at the time of surgery were selected...
February 21, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29473958/is-tissue-still-the-issue-lobectomy-for-suspicious-lung-nodules-without-confirmation-of-malignancy
#4
Suha Kaaki, Biniam Kidane, Sadeesh Srinathan, Lawrence Tan, Gordon Buduhan
BACKGROUND: Histologic confirmation of malignancy has been indicated for a suspicious lung nodule prior to resection. The purpose of this study was to determine whether or not foregoing routine tissue biopsy increased the incidence of lobectomy for benign lesions. METHODS: Retrospective cohort of 256 patients who underwent thoracoscopic or open lobectomy for a confirmed or suspected pulmonary malignancy, with or without tissue diagnosis. Clinical, radiographic, and pathologic data were compared...
February 23, 2018: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29473946/can-pet-ct-help-manage-ground-glass-nodules
#5
EDITORIAL
Francine L Jacobson, Jeffrey N Tarascio, Sam W Fox
No abstract text is available yet for this article.
February 23, 2018: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29473311/her3-expression-is-enhanced-during-progression-of-lung-adenocarcinoma-without-egfr-mutation-from-stage-0-to-ia1
#6
Toru Kumagai, Yasuhiko Tomita, Shin-Ichi Nakatsuka, Madoka Kimura, Kei Kunimasa, Takako Inoue, Motohiro Tamiya, Kazumi Nishino, Yoshiyuki Susaki, Takashi Kusu, Toshiteru Tokunaga, Jiro Okami, Masahiko Higashiyama, Fumio Imamura
BACKGROUND: Activating EGFR mutations, HER2, and HER3 are implicated in lung cancer; however, with the exception of EGFR gene amplification in lung adenocarcinoma harboring EGFR mutations, their involvement in disease progression during the early stages is poorly understood. In this paper, we focused on which receptor is correlated with lung adenocarcinoma progression in the presence or absence of EGFR mutation from stage 0 to IA1. METHODS: HER2 and HER3 expression and activating EGFR mutations in surgically resected lung adenocarcinoma exhibiting ground glass nodules on chest computed tomography and re-classified to stage 0 and IA1 were examined by immunohistochemistry and peptide nucleic acid-locked nucleic acid PCR clamp method, respectively...
February 23, 2018: Thoracic Cancer
https://www.readbyqxmd.com/read/29473157/nodule-of-achilles-tendon-in-a-patient-with-kidney-transplant-revealing-phaeohyphomycosis
#7
Sébastien Ottaviani, Ghislaine Gill, Laurence Choudat, Christophe Rioux, Philippe Dieudé
No abstract text is available yet for this article.
February 23, 2018: International Journal of Dermatology
https://www.readbyqxmd.com/read/29473129/agile-convolutional-neural-network-for-pulmonary-nodule-classification-using-ct-images
#8
Xinzhuo Zhao, Liyao Liu, Shouliang Qi, Yueyang Teng, Jianhua Li, Wei Qian
OBJECTIVE: To distinguish benign from malignant pulmonary nodules using CT images is critical for their precise diagnosis and treatment. A new Agile convolutional neural network (CNN) framework is proposed to conquer the challenges of a small-scale medical image database and the small size of the nodules, and it improves the performance of pulmonary nodule classification using CT images. METHODS: A hybrid CNN of LeNet and AlexNet is constructed through combining the layer settings of LeNet and the parameter settings of AlexNet...
February 23, 2018: International Journal of Computer Assisted Radiology and Surgery
https://www.readbyqxmd.com/read/29472768/effect-of-zhen-qi-fu-zheng-granules-on-the-bone-marrow-depression-model-induced-by-zidorf
#9
Mingsan Miao, Lihua Cao, Ming Bai, Gangling Chen
Zidorf is a commonly used drug for the treatment of AIDS, the most common side effects of AZT was bone marrow depression. Therefore, we investigated the effects of Zhen Qi Fu Zheng (AQFZ) granules on the model of bone marrow depression induced by AZT. We showed that the high, medium and low doses of AQFZ granules could increase the number of WBC in the mice model induced by AZT, and the difference was significant ( P  < 0.01) compared with the model group. Each dose of AQFZ granules can increase the thymus cortex thickness, the number of thymus lymphocytes, spleen nodule size, the number of lymphocytes in the spleen ( P  < 0...
February 2018: Saudi Journal of Biological Sciences
https://www.readbyqxmd.com/read/29472492/angiomatoid-fibrous-histiocytoma-with-paraneoplastic-platelet-storage-pool-deficiency
#10
Lerraughn M Morgan, Emily R Miller, Ashok B Raj, Susan C Coventry, Jennifer D Elster
Angiomatoid fibrous histiocytoma is a rare soft tissue tumor usually discovered in young individuals. This tumor is often mistaken for a hematoma and typically misdiagnosed. It is commonly found in the extremities and may be associated with a site of recent or previous trauma. Characteristic histology includes nodules of histiocytoid spindle cells with pseudoangiomatoid spaces, fibrous pseudocapsules, and lymphoid cuffing. We describe the case of an 8-year-old girl who presented after incision and drainage of a superficial thigh lesion and experienced subsequent chronic bleeding of her wound...
February 22, 2018: Pediatrics
https://www.readbyqxmd.com/read/29472113/revised-value-of-contrast-enhanced-ultrasound-for-solid-hypo-echoic-thyroid-nodules-graded-with-the-thyroid-imaging-reporting-and-data-system
#11
YanFang Wang, Fang Nie, Ting Liu, Dan Yang, Qi Li, Jing Li, AiLing Song
The use of ultrasound in differentiation of benign and malignant solid hypo-echoic thyroid nodules is a dilemma in clinical practice. The aim of this study was to investigate the revised value of contrast-enhanced ultrasound (CEUS) for differentiating solid hypo-echoic thyroid nodules using the Thyroid Imaging Reporting and Data System (TI-RADS).The study included 135 patients with 135 nodules confirmed by fine-needle aspiration and/or surgery. Every nodule underwent both conventional US and CEUS. Binary logistic regression analysis for conventional US features revealed that irregular shape, microcalcification and height greater than width were significant malignant predictive features...
February 19, 2018: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/29471619/post-surgical-recurrence-of-hcc-along-resection-margin-treated-by-percutaneous-us-guided-ablation
#12
Marco Calandri, Carlo Gazzera, Steven Yevich, Katia Lapenna, Maria Marenco, Andrea Veltri, Gianluca Paraluppi, Paolo Fonio
BACKGROUND: To evaluate the safety and efficacy of percutaneous ablation for HCC hepatic recurrence along surgical resection margins to achieve complete cure or bridge for additional treatment. No current recommendations exist for these lesions. METHODS: Retrospective review of post-surgical recurrent HCC located along surgical margins treated by percutaneous ultrasound-guided ablation from 2006-2014. Ablation was performed by radiofrequency ablation (RFA) or percutaneous ethanol injection (PEI), selected for recurrence in proximity to extrahepatic organs...
February 21, 2018: Minerva Chirurgica
https://www.readbyqxmd.com/read/29471517/the-role-of-the-ground-glass-opacity-ratio-in-resected-lung-adenocarcinoma
#13
Tsai-Wang Huang, Kuan-Hsun Lin, Hsu-Kai Huang, Yi-I Chen, Kai-Hsiung Ko, Cheng-Kuang Chang, Hsian-He Hsu, Hung Chang, Shih-Chun Lee
OBJECTIVES: The goal of this study was to investigate the role of the ground-glass opacity (GGO) ratio in lung adenocarcinoma in predicting surgical outcomes. METHODS: Patients who underwent surgical resection for pulmonary adenocarcinoma between January 2004 and December 2013 were reviewed. The clinical data, imaging characteristics of nodules, surgical approaches and outcomes were analysed with a mean follow-up of 87 months. RESULTS: Of 789 enrolled patients, 267 cases were categorized as having a GGO ratio ≥0...
February 19, 2018: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/29470700/incidental-diagnosis-of-parathyroid-lesions-by-preoperative-use-of-next-generation-molecular-testing
#14
Wu Bo, Karen E Schoedel, Sally E Carty, Lisa A Radkay, N Paul Ohori, Yuri E Nikiforov, Marina N Nikiforova, Linwah Yip
BACKGROUND: Parathyroid glands can mimic thyroid follicular lesions on fine-needle aspiration (FNA) cytology and can lead to unnecessary or incorrect surgery. Newer molecular panel tests using next-generation sequencing (NGS) include analysis of cell type-specific gene expression profiles such as parathyroid. The study aim is to determine the frequency and clinical implications of parathyroid tissue identification by molecular testing in cytologically indeterminate "thyroid" lesions...
February 22, 2018: World Journal of Surgery
https://www.readbyqxmd.com/read/29470629/adding-ancillary-features-to-enhancement-patterns-of-hepatocellular-carcinoma-on-gadoxetic-acid-enhanced-magnetic-resonance-imaging-improves-diagnostic-performance
#15
Ji Hye Min, Young Kon Kim, Dong Hyun Sinn, Seo-Youn Choi, Woo Kyoung Jeong, Won Jae Lee, Sang Yun Ha, Soohyun Ahn, Min-Ji Kim
PURPOSE: To assess the added value of intratumoral ancillary features to conventional enhancement pattern-based diagnosis of hepatocellular carcinoma (HCC) on gadoxetic acid-enhanced magnetic resonance imaging (MRI). MATERIALS AND METHODS: A total of 773 consecutive patients with surgically resected 773 primary hepatic tumors (699 HCCs, 63 intrahepatic cholangiocarcinomas, and 11 benign nodules) who underwent gadoxetic acid-enhanced MRI were retrospectively identified...
February 22, 2018: Abdominal Radiology
https://www.readbyqxmd.com/read/29470162/pulmonary-mucormycosis-radiologic-features-at-presentation-and-over-time
#16
Mark M Hammer, Rachna Madan, Hiroto Hatabu
OBJECTIVE: Pulmonary mucormycosis is an aggressive opportunistic fungal infection. We set out to evaluate the CT and MRI features of pulmonary mucormycosis. MATERIALS AND METHODS: Through a search of the electronic medical record from 2007 to 2017, we identified 30 patients with definite or probable mucormycosis. Two radiologists reviewed the initial chest CT examinations for the presence of features including the "reverse halo" sign, large ground-glass halo, and peripheral lesion distribution...
February 22, 2018: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29469994/what-is-your-diagnosis-cutaneous-nodules-and-atypical-blood-cells-in-a-dog
#17
Ricardo Marcos, Ana Canadas, Liliana Leite-Martins, Jorge Ribeiro, Joana Santos, Augusto de Matos, John W Harvey, Marta Santos
No abstract text is available yet for this article.
February 22, 2018: Veterinary Clinical Pathology
https://www.readbyqxmd.com/read/29469798/complete-resolution-of-erythema-elevatum-diutinum-using-oral-sulfasalazine
#18
Michael L Chen, Agata Chlopik, Maija P Hoang, Gideon P Smith
Erythema elevatum diutinum (EED) is a rare, chronic small-vessel vasculitis that presents as firm, red, violaceous, or brown papules and nodules on the extensor surfaces of the limbs. Oral dapsone is considered first-line therapy for EED; in the current case report, a patient presenting with EED began dapsone treatment and symptoms subsided within two weeks. Seven months later, the patient became pregnant and stopped dapsone owing to her concerns with dapsone use during pregnancy, resulting in recurrence of EED symptoms...
October 15, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/29469793/lesiones-subcut%C3%A3-neas-dolorosas-en-paciente-con-melanoma-metast%C3%A3-sico-un-caso-de-paniculitis-linfoc%C3%A3-tica-asociado-a-vemurafenib
#19
Felipe Benavente-Villegas, Francisco Ferrando-Roca, Raquel Dolz-Gaitón, María Royo-Peiró
Vemurafenib ha probado ser una herramienta útil en el tratamiento de melanoma metastásico con mutación BRAF-V600E. Los efectos adversos incluyen artralgias, fatiga y toxicidad cutánea, siendo infrecuente la paniculitis. Presentamos el caso de una paciente de 43 años con melanoma metastásico que desarrolla lesiones subcutáneas dolorosas en miembros inferiores y superiores, asociadas a clínica sistémica después de 2 semanas de inicio de tratamiento con Vemurafenib + Cobimetinib. La histología demostró paniculitis linfocitaria septal y lobulillar...
October 15, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/29469792/kimura-disease
#20
Pengjun Zhou, Weitao Zhang, Wangrong Shi, Yanfei Zhang
Kimura disease is a rare, benign, chronic, immune-mediated inflammatory disorder. We report a 46-year-old man who presented with a cutaneous nodule behind his left ear. Surgical removal of the growth confirmed the histological diagnosis of KD. There was no recurrence found after 3 years follow-up.
October 15, 2017: Dermatology Online Journal
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