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Chikatsugu Tsuchida, Sumiyo Sakuramoto-Tsuchida, Maiko Taked, Asako Itaya-Hironaka, Akiyo Yamauchi, Masayasu Misu, Ryogo Shobatake, Tomoko Uchiyama, Mai Makino, Irma Pujol-Autonell, Marta Vives-Pi, Chiho Ohbayashi, Shin Takasawa
The pathophysiology of inflammatory bowel disease (IBD) reflects a balance between mucosal injury and reparative mechanisms. Some regenerating gene (Reg) family members have been reported to be expressed in Crohn's disease (CD) and ulcerative colitis (UC) and to be involved as proliferative mucosal factors in IBD. However, expression of all REG family genes in IBD is still unclear. Here, we analyzed expression of all REG family genes (REG Iα, REG Iβ, REG III, HIP/PAP, and REG IV) in biopsy specimens of UC and CD by real-time RT-PCR...
December 2017: Biochemistry and Biophysics Reports
Tomoko Uchiyama, Hiroyo Ota, Asako Itaya-Hironaka, Ryogo Shobatake, Akiyo Yamauchi, Sumiyo Sakuramoto-Tsuchida, Mai Makino, Hiroshi Kimura, Maiko Takeda, Chiho Ohbayashi, Shin Takasawa
Sleep apnea syndrome is characterized by recurrent episodes of oxygen desaturation and reoxygenation (intermittent hypoxia [IH]) and is a risk factor for insulin resistance/type 2 diabetes. However, the mechanisms linking IH stress and insulin resistance remain elusive. We exposed human hepatocytes (JHH5, JHH7, and HepG2) to experimental IH or normoxia for 24 h, measured mRNA levels by real-time reverse transcription polymerase chain reaction (RT-PCR), and found that IH significantly increased the mRNA levels of selenoprotein P (SELENOP) - a hepatokine - and hepatocarcinoma-intestine-pancreas/pancreatitis-associated protein (HIP/PAP) - one of REG (Regenerating gene) family...
September 2017: Biochemistry and Biophysics Reports
Antonio Dello Iacono, Johnny Padulo, Laurent D Seitz
This study aimed to investigate the acute effects of two barbell hip thrust-based (BHT) post-activation potentiation (PAP) protocols on subsequent sprint performance. Using a crossover design, eighteen handball athletes performed maximal 15-m sprints before and 15s, 4min and 8min after two experimental protocols consisting of BHT loaded with either 50% or 85% 1RM (50PAP and 85PAP, respectively), in order to profile the transient PAP effects. The resulting sprint performances were significantly impaired at 15s only after the 85PAP protocol, which induced likely and very likely greater decreases compared to the 50PAP...
September 5, 2017: Journal of Sports Sciences
Thelonius Hawellek, Jan Hubert, Sandra Hischke, Matthias Krause, Jessica Bertrand, Thomas Pap, Klaus Püschel, Wolfgang Rüther, Andreas Niemeier
OBJECTIVES: Based on the concept of a systemic predisposition for articular cartilage calcification (CC), the aim of this study was to determine the prevalence and amount of bilateral CC of hip and knee joints in an unselected sample cohort by high-resolution digital contact radiography (DCR) and to analyze the association of CC with histological OA. METHODS: Both hip and knee joints of 87 donors (48 m and 39 f; mean age 62) were analyzed by DCR in this post-mortem study of an unselected cohort of donors...
July 4, 2016: Osteoarthritis and Cartilage
Felipe García-Pinillos, Alejandro Molina-Molina, Pedro Á Latorre-Román
This study aimed to determine whether kinematic data during countermovement jump (CMJ) might explain post-activation potentiation (PAP) phenomenon after an exhausting running test. Thirty-three trained endurance runners performed the Léger Test; an incremental test which consists of continuous running between two lines 20 m apart. CMJ performance was determined before (pre-test) and immediately after the protocol (post-test). Sagittal plane, video of CMJs was recorded and kinematic data were obtained throughout 2-Dimensional analysis...
June 2016: Sports Biomechanics
Thelonius Hawellek, Jan Hubert, Sandra Hischke, Eik Vettorazzi, Karl Wegscheider, Jessica Bertrand, Thomas Pap, Matthias Krause, Klaus Püschel, Wolfgang Rüther, Andreas Niemeier
Articular cartilage calcification is considered a pathological albeit incompletely understood process which is known to be associated with osteoarthritis of the knee and hip. The goal of this study was to determine the prevalence of articular cartilage calcification of the shoulder as a non-weight-bearing joint and to analyze the interrelationship of calcification with age and histological severity of shoulder osteoarthritis in the general population. In a cross-sectional study of 180 humeral heads from 90 donors (n = 49 male, n = 41 female; mean age 62...
November 2016: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
John David Spencer, Ashley R Jackson, Birong Li, Christina B Ching, Martin Vonau, Robert S Easterling, Andrew L Schwaderer, Kirk M McHugh, Brian Becknell
Recent evidence indicates that antimicrobial peptides (AMPs) serve key roles in defending the urinary tract against invading uropathogens. To date, the individual contribution of AMPs to urinary tract host defense is not well defined. In this study, we identified Regenerating islet-derived 3 gamma (RegIIIγ) as the most transcriptionally up-regulated AMP in murine bladder transcriptomes following uropathogenic Escherichia coli (UPEC) infection. We confirmed induction of RegIIIγ mRNA during cystitis and pyelonephritis by quantitative RT-PCR...
2015: PloS One
Gang Wang, Xin Zhao, De-Chun Li
OBJECTIVE: To investigate the expression of HIP/PAP in hepatocellular carcinoma (HCC) patients and explore its role in migration and invasion of HCC. METHODS: The expression of HIP/PAP in HCC tissue and corresponding adjacent noncancerous tissue was assessed by IHC, RT-PCR and Western blot. The correlation between clinicopathological features and HIP/PAP expression was analyzed. The role of HIP/PAP on invasion and migration of HCC cells was observed by RNA interference, wound healing and Transwell assay...
October 2015: Asian Pacific Journal of Tropical Medicine
Antonella Agodi, Francesco Auxilia, Martina Barchitta, Maria Luisa Cristina, Ida Mura, Marta Nobile, Cesira Pasquarella
BACKGROUND: The Perioperative Antibiotic Prophylaxis (PAP) contributes considerably to the total amount of antibiotics used in hospitals and has been shown to be associated with increase in antibiotic resistance and healthcare costs. The level of compliance with the national guidelines of current practices of PAP for elective hip and knee prosthesis procedures in a network of Italian hospitals (the multicentre Surgical Site Infection surveillance project GISIO-ISChIA), has been evaluated...
May 2015: Annali di Igiene: Medicina Preventiva e di Comunità
Nicolas Moniaux, Marion Darnaud, Kévin Garbin, Alexandre Dos Santos, Catherine Guettier, Didier Samuel, Gilles Amouyal, Paul Amouyal, Christian Bréchot, Jamila Faivre
BACKGROUND AND AIMS: Acute liver failure (ALF) is a rapidly progressive heterogeneous illness with high mortality rate and no widely accessible cure. A promising drug candidate according to previous preclinical studies is the Reg3α (or HIP/PAP) lectin, which alleviates ALF through its free-radical scavenging activity. Here we study the therapeutic targets of Reg3α in order to gain information on the nature of the oxidative stress associated with ALF. METHODS: Primary hepatocytes stressed with the reactive oxygen species (ROS) inducers TNFα and H2O2 were incubated with a recombinant Reg3α protein...
2015: PloS One
Akiyo Yamauchi, Asako Itaya-Hironaka, Sumiyo Sakuramoto-Tsuchida, Maiko Takeda, Kiyomi Yoshimoto, Tomoko Miyaoka, Takanori Fujimura, Hiroki Tsujinaka, Chikatsugu Tsuchida, Hiroyo Ota, Shin Takasawa
Reg (Regenerating gene) gene was originally isolated from rat regenerating islets and its encoding protein was revealed as an autocrine/paracrine growth factor for β cells. Rat Reg gene is activated in inflammatory conditions for β cell regeneration. In human, although five functional REG family genes (REG Iα, REG Iβ, REG III, HIP/PAP, and REG IV) were isolated, their expressions in β cells under inflammatory conditions remained unclear. In this study, we found that combined addition of IL-6 and dexamethasone (Dx) induced REG Iα and REG Iβ expression in human 1...
2015: Journal of Diabetes Research
Maurizio Marvisi, Maurizio Giuseppe Vento, Laura Balzarini, Chiara Mancini, Chiara Marvisi
OBJECTIVE: Data are sparse regarding the prevalence of pulmonary hypertension (PH) in obstructive sleep apnoea (OSA) patients without COPD and clinically manifest cardiac diseases and the role of continuous positive airway pressure (CPAP) and Uvulopalatopharyngoplasty (UPPP) in normalizing this parameter. PATIENTS/METHODS: We studied 75 consecutive OSA patients, 55 of them men, using transthoracic echocardiography. A mild PH [pulmonary artery pressure (PAPs) 38...
April 2015: Lung
Chi-Chih Lai, Michael Friedman, Hsin-Ching Lin, Pa-Chun Wang, Michelle S Hwang, Cheng-Ming Hsu, Meng-Chih Lin, Chien-Hung Chin
OBJECTIVES/HYPOTHESIS: To identify standard clinical parameters that may predict the optimal level of continuous positive airway pressure (CPAP) in adult patients with obstructive sleep apnea/hypopnea syndrome (OSAHS). STUDY DESIGN: This is a retrospective study in a tertiary academic medical center that included 129 adult patients (117 males and 12 females) with OSAHS confirmed by diagnostic polysomnography (PSG). METHODS: All OSAHS patients underwent successful full-night manual titration to determine the optimal CPAP pressure level for OSAHS treatment...
August 2015: Laryngoscope
Parthiv Haldipur, Nina Dupuis, Vincent Degos, Nicolas Moniaux, Vibol Chhor, Sowmyalakshmi Rasika, Leslie Schwendimann, Tifenn le Charpentier, Elodie Rougier, Paul Amouyal, Gilles Amouyal, Pascal Dournaud, Christian Bréchot, Vincent El Ghouzzi, Jamila Faivre, Bobbi Fleiss, Shyamala Mani, Pierre Gressens
OBJECTIVES: Excitotoxicity plays a significant role in the pathogenesis of perinatal brain injuries. Among the consequences of excessive activation of the N-methyl-d-aspartate (NMDA)-type glutamate are oxidative stress caused by free radical release from damaged mitochondria, neuronal death and subsequent loss of connectivity. Drugs that could protect nervous tissue and support regeneration are attractive therapeutic options. The hepatocarcinoma intestine pancreas protein/pancreatitis-associated protein I (HIP/PAP) or Reg3α, which is approved for clinical testing for the protection and regeneration of the liver, is upregulated in the central nervous system following injury or disease...
October 2014: Annals of Clinical and Translational Neurology
Sofie Jansen, Rudolph W Koster, Frederik J de Lange, J Carel Goslings, Matthias U Schafroth, Sophia E de Rooij, Nathalie van der Velde
BACKGROUND: Several risk factors for falls and hip-fractures have been recognized, but controversy still exists toward the importance of structural cardiac abnormalities as a potentially modifiable risk factor for recurrent falls. Aim of this study was to determine the association between echocardiographic abnormalities and hip-fractures. METHODS: Design case-control study within consecutive patients undergoing hip-surgery in an academic hospital. CASES: patients with traumatic hip-fractures...
January 2015: Archives of Gerontology and Geriatrics
Olav Reikerås, Pål Borgen
BACKGROUND: Traumatic injury induces changes in mediators of inflammation and coagulation, but the pivotal roles of inflammation and coagulation has not been precisely clarified. Therefore we have studied markers of inflammation and coagulation after a standardized musculoskeletal trauma like total hip replacement surgery. METHODS: We allocated 21 patients aged 50 to 84 years who underwent total hip replacement surgery. Releases of TNF-α, IL-1β, IL-6, IL-8 and IL-10 and protrombin fragment F1...
2014: PloS One
Geraldo Ângelo Gonçalves, Eduardo Della Valle Prezzi, Guilherme Marinho Carletti, Giuseppe Chindamo, Tito Henrique Noronha Rocha, Eduardo Varella, Arthur Oswaldo de Abreu Vianna
Anesthetic management of patients with severe chronic obstructive pulmonary disease is extensively discussed, due to the high rates of complications in this subtype of patients submitted to medium and high complexity surgical procedures. The objective of this study is to report use of noninvasive positive pressure mechanical ventilation - bilevel positive airway pressure - and spinal anesthesia in a patient with severe chronic obstructive pulmonary disease during total hip arthroplasty. An 81 year old, male patient with severe chronic obstructive pulmonary disease (GOLD 4) was submitted to total hip arthroplasty due to a femoral bone fracture under spinal anestesia and noninvasive positive pressure mechanical ventilation-bilevel positive airway pressure with expiratory pressure of 7 cmH2O, inspiratory pressure of 15 cmH2O and O2 flow of 3 L/min...
September 2008: Revista Brasileira de Terapia Intensiva
Yi-Chih Huang, Chun-Yao Lin, Chou-Chin Lan, Yao-Kuang Wu, Chor-Shen Lim, Chun-Yao Huang, Hsuan-Li Huang, Kuan-Hung Yeh, Yu-Chih Liu, Mei-Chen Yang
BACKGROUND: This retrospective cohort study aimed to determine if there are differences in cardiovascular co-morbidities, blood pressure (BP) and continuous positive airway pressure (CPAP) use between patients with positional-dependent and nonpositional-dependent obstructive sleep apnea (OSA). METHODS: Patients who were referred for overnight polysomnography for suspected OSA between 2007 and 2011 were screened. A total of 371 patients with OSA were included for analysis and divided into six groups according to positional-dependency and severity of OSA: positional mild (n = 52), positional moderate (n = 29), positional severe (n = 24), non-positional mild (n = 18), non-positional moderate (n = 70) and non-positional severe group (n = 178)...
2014: BMC Pulmonary Medicine
Thiruvengadam Arumugam, Vincenzo Paolillo, Daniel Young, XiaoXia Wen, Craig D Logsdon, Louis De Palatis, Mian M Alauddin
INTRODUCTION: Early detection of pancreatic cancer could save many thousands of lives. Non-invasive diagnostic imaging, including PET with [(18)F]FDG, has inadequate resolution for detection of small (2-3 mm) pancreatic tumours. We demonstrated the efficacy of PET imaging with an (18)F-labelled lactose derivative, [(18)F]FEDL, that targets HIP/PAP, a biomarker that is overexpressed in the peritumoural pancreas. We developed another analogue, 1-[(18)F]fluoroethyl lactose ([(18)F]FEL), which is simpler to synthesise, for the same application...
November 2014: Nuclear Medicine and Biology
Atsuki Fukutani, Kosuke Hirata, Naokazu Miyamoto, Hiroaki Kanehisa, Toshimasa Yanai, Yasuo Kawakami
We aimed to examine whether the influence of conditioning contraction intensity on the extent of postactivation potentiation (PAP) is muscle dependent. Eleven healthy males performed both thumb adduction and plantar flexion as a conditioning contraction. The conditioning contraction intensities were set at 20%, 40%, 60%, 80%, or 100% of the maximal voluntary isometric contraction (MVC). Before and after the conditioning contraction, twitch torque was measured for the respective joint to calculate the extent of PAP...
April 2014: Journal of Electromyography and Kinesiology
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