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pratip bhattacharya

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https://www.readbyqxmd.com/read/27784287/induction-of-autophagy-by-arhi-diras3-alters-fundamental-metabolic-pathways-in-ovarian-cancer-models
#1
Argentina Ornelas, Christopher R McCullough, Zhen Lu, Niki M Zacharias, Lindsay E Kelderhouse, Joshua Gray, Hailing Yang, Brian J Engel, Yan Wang, Weiqun Mao, Margie N Sutton, Pratip K Bhattacharya, Robert C Bast, Steven W Millward
BACKGROUND: Autophagy is a bulk catabolic process that modulates tumorigenesis, therapeutic resistance, and dormancy. The tumor suppressor ARHI (DIRAS3) is a potent inducer of autophagy and its expression results in necroptotic cell death in vitro and tumor dormancy in vivo. ARHI is down-regulated or lost in over 60 % of primary ovarian tumors yet is dramatically up-regulated in metastatic disease. The metabolic changes that occur during ARHI induction and their role in modulating death and dormancy are unknown...
October 26, 2016: BMC Cancer
https://www.readbyqxmd.com/read/27742110/interrogating-metabolism-in-brain-cancer
#2
REVIEW
Travis C Salzillo, Jingzhe Hu, Linda Nguyen, Nicholas Whiting, Jaehyuk Lee, Joseph Weygand, Prasanta Dutta, Shivanand Pudakalakatti, Niki Zacharias Millward, Seth T Gammon, Frederick F Lang, Amy B Heimberger, Pratip K Bhattacharya
This article reviews existing and emerging techniques of interrogating metabolism in brain cancer from well-established proton magnetic resonance spectroscopy to the promising hyperpolarized metabolic imaging and chemical exchange saturation transfer and emerging techniques of imaging inflammation. Some of these techniques are at an early stage of development and clinical trials are in progress in patients to establish the clinical efficacy. It is likely that in vivo metabolomics and metabolic imaging is the next frontier in brain cancer diagnosis and assessing therapeutic efficacy; with the combined knowledge of genomics and proteomics a complete understanding of tumorigenesis in brain might be achieved...
November 2016: Magnetic Resonance Imaging Clinics of North America
https://www.readbyqxmd.com/read/27547777/developing-hyperpolarized-silicon-particles-for-in-vivo-mri-targeting-of-ovarian-cancer
#3
Nicholas Whiting, Jingzhe Hu, Niki M Zacharias, Ganesh L R Lokesh, David E Volk, David G Menter, Rajesha Rupaimoole, Rebecca Previs, Anil K Sood, Pratip Bhattacharya
Silicon-based nanoparticles are ideally suited for use as biomedical imaging agents due to their biocompatibility, biodegradability, and simple surface chemistry that facilitates drug loading and targeting. A method of hyperpolarizing silicon particles using dynamic nuclear polarization, which increases magnetic resonance imaging signals by several orders-of-magnitude through enhanced nuclear spin alignment, has recently been developed to allow silicon particles to function as contrast agents for in vivo magnetic resonance imaging...
July 2016: Journal of Medical Imaging
https://www.readbyqxmd.com/read/27547490/towards-real-time-metabolic-profiling-of-cancer-with-hyperpolarized-succinate
#4
Niki M Zacharias, Christopher R McCullough, Shawn Wagner, Napapon Sailasuta, Henry R Chan, Youngbok Lee, Jingzhe Hu, William H Perman, Cameron Henneberg, Brian D Ross, Pratip Bhattacharya
PURPOSE: The energy-yielding mitochondrial Krebs cycle has been shown in many cancers and other diseases to be inhibited or mutated. In most cells, the Krebs cycle with oxidative phosphorylation generates approximately 90% of the adenosine triphosphate in the cell. We designed and hyperpolarized carbon-13 labeled succinate (SUC) and its derivative diethyl succinate (DES) to interrogate the Krebs cycle in real-time in cancer animal models. PROCEDURES: Using Parahydrogen Induced Polarization (PHIP), we generated hyperpolarized SUC and DES by hydrogenating their respective fumarate precursors...
June 2016: Journal of Molecular Imaging & Dynamics
https://www.readbyqxmd.com/read/26819345/role-of-increased-n-acetylaspartate-levels-in-cancer
#5
Behrouz Zand, Rebecca A Previs, Niki M Zacharias, Rajesha Rupaimoole, Takashi Mitamura, Archana Sidalaghatta Nagaraja, Michele Guindani, Heather J Dalton, Lifeng Yang, Joelle Baddour, Abhinav Achreja, Wei Hu, Chad V Pecot, Cristina Ivan, Sherry Y Wu, Christopher R McCullough, Kshipra M Gharpure, Einav Shoshan, Sunila Pradeep, Lingegowda S Mangala, Cristian Rodriguez-Aguayo, Ying Wang, Alpa M Nick, Michael A Davies, Guillermo Armaiz-Pena, Jinsong Liu, Susan K Lutgendorf, Keith A Baggerly, Menashe Bar Eli, Gabriel Lopez-Berestein, Deepak Nagrath, Pratip K Bhattacharya, Anil K Sood
BACKGROUND: The clinical and biological effects of metabolic alterations in cancer are not fully understood. METHODS: In high-grade serous ovarian cancer (HGSOC) samples (n = 101), over 170 metabolites were profiled and compared with normal ovarian tissues (n = 15). To determine NAT8L gene expression across different cancer types, we analyzed the RNA expression of cancer types using RNASeqV2 data available from the open access The Cancer Genome Atlas (TCGA) website (http://www...
June 2016: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/26686630/long-noncoding-rna-ceruloplasmin-promotes-cancer-growth-by-altering-glycolysis
#6
Rajesha Rupaimoole, Jaehyuk Lee, Monika Haemmerle, Hui Ling, Rebecca A Previs, Sunila Pradeep, Sherry Y Wu, Cristina Ivan, Manuela Ferracin, Jennifer B Dennison, Niki M Zacharias Millward, Archana S Nagaraja, Kshipra M Gharpure, Michael McGuire, Nidhin Sam, Guillermo N Armaiz-Pena, Nouara C Sadaoui, Cristian Rodriguez-Aguayo, George A Calin, Ronny I Drapkin, Jeffery Kovacs, Gordon B Mills, Wei Zhang, Gabriel Lopez-Berestein, Pratip K Bhattacharya, Anil K Sood
Long noncoding RNAs (lncRNAs) significantly influence the development and regulation of genome expression in cells. Here, we demonstrate the role of lncRNA ceruloplasmin (NRCP) in cancer metabolism and elucidate functional effects leading to increased tumor progression. NRCP was highly upregulated in ovarian tumors, and knockdown of NRCP resulted in significantly increased apoptosis, decreased cell proliferation, and decreased glycolysis compared with control cancer cells. In an orthotopic mouse model of ovarian cancer, siNRCP delivered via a liposomal carrier significantly reduced tumor growth compared with control treatment...
December 22, 2015: Cell Reports
https://www.readbyqxmd.com/read/26603259/hypoxia-activated-prodrug-th-302-targets-hypoxic-bone-marrow-niches-in-preclinical-leukemia-models
#7
Juliana Benito, Marc S Ramirez, Niki Zacharias Millward, Juliana Velez, Karine G Harutyunyan, Hongbo Lu, Yue-Xi Shi, Polina Matre, Rodrigo Jacamo, Helen Ma, Sergej Konoplev, Teresa McQueen, Andrei Volgin, Marina Protopopova, Hong Mu, Jaehyuk Lee, Pratip K Bhattacharya, Joseph R Marszalek, R Eric Davis, James A Bankson, Jorge E Cortes, Charles P Hart, Michael Andreeff, Marina Konopleva
PURPOSE: To characterize the prevalence of hypoxia in the leukemic bone marrow, its association with metabolic and transcriptional changes in the leukemic blasts and the utility of hypoxia-activated prodrug TH-302 in leukemia models. EXPERIMENTAL DESIGN: Hyperpolarized magnetic resonance spectroscopy was utilized to interrogate the pyruvate metabolism of the bone marrow in the murine acute myeloid leukemia (AML) model. Nanostring technology was used to evaluate a gene set defining a hypoxia signature in leukemic blasts and normal donors...
April 1, 2016: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/26239953/real-time-mri-guided-catheter-tracking-using-hyperpolarized-silicon-particles
#8
Nicholas Whiting, Jingzhe Hu, Jay V Shah, Maja C Cassidy, Erik Cressman, Niki Zacharias Millward, David G Menter, Charles M Marcus, Pratip K Bhattacharya
Visualizing the movement of angiocatheters during endovascular interventions is typically accomplished using x-ray fluoroscopy. There are many potential advantages to developing magnetic resonance imaging-based approaches that will allow three-dimensional imaging of the tissue/vasculature interface while monitoring other physiologically-relevant criteria, without exposing the patient or clinician team to ionizing radiation. Here we introduce a proof-of-concept development of a magnetic resonance imaging-guided catheter tracking method that utilizes hyperpolarized silicon particles...
2015: Scientific Reports
https://www.readbyqxmd.com/read/26232369/metabolic-imaging-as-a-biomarker-of-early-radiation-response-in-tumors
#9
COMMENT
Stephen Y Lai, C David Fuller, Pratip K Bhattacharya, Steven J Frank
(13)C-pyruvate hyperpolarized magnetic resonance imaging (HP-MRI) is emerging as a viable quantitative biomarker for solid tumor response and normal tissue toxicity after radiotherapy. This technology effectively predicts response related to metabolic agents or alterations in the tumor microenvironment, but challenges remain to be addressed to ensure successful translational implementation. See related article by Saito et al., p. 5073.
November 15, 2015: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/23469570/prevalence-of-hiv-seropositivity-among-surgical-patients-in-a-tertiary-care-hospital
#10
Susmita Bhattacharya, Banya Chakrabarty, Pratip Kumar Kundu, Abhiram Maji, S R Ghosal, Krishna Kamal Dey
The incidence of HIV infection has increased tremendously over the last few years. The new 2006 estimates released by the National AIDS Control Organisation (NACO), supported by UNAIDS and WHO, indicate that national adult HIV prevalence in India is approximately 0.36%, which corresponds to an estimated 2 million to 3.1 million people living with HIV in this country. The positive rate of HIV tested persons has shown a rising trend. So, a study was conducted on patients attending the surgery department for different operative procedures and 13 patients were HIV reactive out of 1697 patients tested...
December 2011: Journal of the Indian Medical Association
https://www.readbyqxmd.com/read/22996746/hyperpolarized-water-as-an-mr-imaging-contrast-agent-feasibility-of-in-vivo-imaging-in-a-rat-model
#11
Mark D Lingwood, Ting Ann Siaw, Napapon Sailasuta, Osama A Abulseoud, Henry R Chan, Brian D Ross, Pratip Bhattacharya, Songi Han
PURPOSE: To assess the feasibility of a perfusion magnetic resonance (MR) imaging technique that uses Overhauser dynamic nuclear polarization (DNP) to provide contrast during the continuous delivery of hyperpolarized water in rats. MATERIALS AND METHODS: Protocols approved by the local institutional animal care and use committees were followed. Twelve male Wistar rats were anesthetized and prepared by placing injection tubing in the subcutaneous layer (n=3), peritoneum (n=3), aorta (n=3), or carotid artery (n=3)...
November 2012: Radiology
https://www.readbyqxmd.com/read/22146049/real-time-molecular-imaging-of-tricarboxylic-acid-cycle-metabolism-in-vivo-by-hyperpolarized-1-13-c-diethyl-succinate
#12
Niki M Zacharias, Henry R Chan, Napapon Sailasuta, Brian D Ross, Pratip Bhattacharya
The Krebs tricarboxylic acid cycle (TCA) is central to metabolic energy production and is known to be altered in many disease states. Real-time molecular imaging of the TCA cycle in vivo will be important in understanding the metabolic basis of several diseases. Positron emission tomography (PET) with FDG-glucose (2-[(18)F]fluoro-2-deoxy-d-glucose) is already being used as a metabolic imaging agent in clinics. However, FDG-glucose does not reveal anything past glucose uptake and phosphorylation. We have developed a new metabolic imaging agent, hyperpolarized diethyl succinate-1-(13)C-2,3-d(2) , that allows for real-time in vivo imaging and spectroscopy of the TCA cycle...
January 18, 2012: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/21538638/parahydrogen-induced-polarization-phip-hyperpolarized-mr-receptor-imaging-in-vivo-a-pilot-study-of-13c-imaging-of-atheroma-in-mice
#13
Pratip Bhattacharya, Eduard Y Chekmenev, Wanda F Reynolds, Shawn Wagner, Niki Zacharias, Henry R Chan, Rolf Bünger, Brian D Ross
MR techniques using hyperpolarized (13)C have successfully produced examples of angiography and intermediary metabolic imaging, but, to date, no receptor imaging has been attempted. The goal of this study was to synthesize and evaluate a novel hyperpolarizable molecule, 2,2,3,3-tetrafluoropropyl 1-(13)C-propionate-d(2,3,3) (TFPP), for the detection of atheromatous plaques in vivo. TFPP binds to lipid bilayers and its use in hyperpolarized MR could prove to be a major step towards receptor imaging. The precursor, 2,2,3,3-tetrafluoropropyl 1-(13)C-acrylate-d(2,3,3) (TFPA), binds to 1,2-dimyristoylphosphatidylcholine lipid bilayers with a 1...
October 2011: NMR in Biomedicine
https://www.readbyqxmd.com/read/20809893/application-of-nmr-spectroscopy-in-medicinal-chemistry-and-drug-discovery
#14
REVIEW
Brian Ross, Thao Tran, Pratip Bhattacharya, D Martin Watterson, Napapon Sailasuta
We describe the details of the magnetic resonance spectroscopy and chemical shift imaging techniques for the human brain which have been developed over the last two decades. With these non-invasive tools, it is now readily possible to repeatedly assay up to 20 common brain metabolites. From the perspective of drug discovery, each of these metabolites could fulfill a number of useful functions: disease biomarker, surrogate marker of drug delivery, surrogate marker of drug efficacy and so on. To facilitate the possible utility of clinical magnetic resonance spectroscopy in future drug discovery, the major portion of the review is devoted to a detailed description of the well-validated neurochemical profiles of many common human brain disorders, for which MRS data now exists...
2011: Current Topics in Medicinal Chemistry
https://www.readbyqxmd.com/read/20541445/continuous-flow-overhauser-dynamic-nuclear-polarization-of-water-in-the-fringe-field-of-a-clinical-magnetic-resonance-imaging-system-for-authentic-image-contrast
#15
Mark D Lingwood, Ting Ann Siaw, Napapon Sailasuta, Brian D Ross, Pratip Bhattacharya, Songi Han
We describe and demonstrate a system to generate hyperpolarized water in the 0.35 T fringe field of a clinical 1.5 T whole-body magnetic resonance imaging (MRI) magnet. Once generated, the hyperpolarized water is quickly and continuously transferred from the 0.35 T fringe to the 1.5 T center field of the same magnet for image acquisition using standard MRI equipment. The hyperpolarization is based on Overhauser dynamic nuclear polarization (DNP), which effectively and quickly transfers the higher spin polarization of free radicals to nuclear spins at ambient temperatures...
August 2010: Journal of Magnetic Resonance
https://www.readbyqxmd.com/read/20171034/fast-volumetric-spatial-spectral-mr-imaging-of-hyperpolarized-13c-labeled-compounds-using-multiple-echo-3d-bssfp
#16
William H Perman, Pratip Bhattacharya, Jochen Leupold, Alexander P Lin, Kent C Harris, Valerie A Norton, Jan-Bernd Hövener, Brian D Ross
PURPOSE: The goal of this work was to develop a fast 3D chemical shift imaging technique for the noninvasive measurement of hyperpolarized (13)C-labeled substrates and metabolic products at low concentration. MATERIALS AND METHODS: Multiple echo 3D balanced steady state magnetic resonance imaging (ME-3DbSSFP) was performed in vitro on a syringe containing hyperpolarized [1,3,3-2H3; 1-(13)C]2-hydroxyethylpropionate (HEP) adjacent to a (13)C-enriched acetate phantom, and in vivo on a rat before and after intravenous injection of hyperpolarized HEP at 1...
May 2010: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/19934362/cardiovascular-applications-of-hyperpolarized-contrast-media-and-metabolic-tracers
#17
REVIEW
Pratip Bhattacharya, Brian D Ross, Rolf Bünger
Modern hyperpolarization technology enhances the recordable magnetic resonance signal four to five orders of magnitude, making in vivo assessments of tracer pathways and metabolic compartments feasible. Existing hyperpolarization instrumentation and previous tracer studies using hydroxyethylpropionate (HEP) as an extracellular marker and 14-carbon label pyruvate as examples are described and reviewed as applicable to the working heart. Future metabolic imaging based on the use of hyperpolarized pyruvate needs to consider extra- and intra-cellular label dilution due to glycolysis, lactate oxidation and protein degradation...
December 2009: Experimental Biology and Medicine
https://www.readbyqxmd.com/read/19256566/hyperpolarized-1-h-nmr-employing-low-gamma-nucleus-for-spin-polarization-storage
#18
Eduard Y Chekmenev, Valerie A Norton, Daniel P Weitekamp, Pratip Bhattacharya
Here, we demonstrate the utility of low gamma nuclei for spin storage of hyperpolarization followed by proton detection, which theoretically can provide up to approximately (gamma[1H]/gamma[X])(2) gain in sensitivity in hyperpolarized biomedical MR. This is exemplified by hyperpolarized 1-(13)C sites of 2,2,3,3-tetrafluoropropyl 1-(13)C-propionate-d(3) (TFPP), (13)C T(1) = 67 s in D(2)O, and 1-(13)C-succinate-d(2), (13)C T(1) = 105 s in D(2)O, pH 11, using PASADENA. In a representative example, the spin polarization was stored on (13)C for 24 and 70 s, respectively, while the samples were transferred from a low magnetic field polarizer operating at 1...
March 11, 2009: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/19067009/quality-assurance-of-pasadena-hyperpolarization-for-13c-biomolecules
#19
Jan-Bernd Hövener, Eduard Y Chekmenev, Kent C Harris, William H Perman, Thao T Tran, Brian D Ross, Pratip Bhattacharya
OBJECT: Define MR quality assurance procedures for maximal PASADENA hyperpolarization of a biological (13)C molecular imaging reagent. MATERIALS AND METHODS: An automated PASADENA polarizer and a parahydrogen generator were installed. (13)C enriched hydroxyethyl acrylate, 1-(13)C, 2,3,3-d(3) (HEA), was converted to hyperpolarized hydroxyethyl propionate, 1-(13)C, 2,3,3-d(3) (HEP) and fumaric acid, 1-(13)C, 2,3-d(2) (FUM) to hyperpolarized succinic acid, 1-(13)C, 2,3-d(2) (SUC), by reaction with parahydrogen and norbornadiene rhodium catalyst...
April 2009: Magma
https://www.readbyqxmd.com/read/19067008/pasadena-hyperpolarization-of-13c-biomolecules-equipment-design-and-installation
#20
Jan-Bernd Hövener, Eduard Y Chekmenev, Kent C Harris, William H Perman, Larry W Robertson, Brian D Ross, Pratip Bhattacharya
OBJECT: The PASADENA method has achieved hyperpolarization of 16-20% (exceeding 40,000-fold signal enhancement at 4.7 T), in liquid samples of biological molecules relevant to in vivo MRI and MRS. However, there exists no commercial apparatus to perform this experiment conveniently and reproducibly on the routine basis necessary for translation of PASADENA to questions of biomedical importance. The present paper describes equipment designed for rapid production of six to eight liquid samples per hour with high reproducibility of hyperpolarization...
April 2009: Magma
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