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magnetic resonance fingerprinting

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https://www.readbyqxmd.com/read/28075583/amyloid-fibril-polymorphism-almost-identical-on-the-atomic-level-mesoscopically-very-different
#1
Carolin Seuring, Joeri Verasdonck, Philippe Ringler, Riccardo Cadalbert, Henning Stahlberg, Anja Böckmann, Beat H Meier, Roland Riek
Amyloid polymorphism of twisted and straight β-endorphin fibril was studied by negative-stain transmission electron microscopy, scanning transmission electron microscopy, and solid-state nuclear magnetic resonance spectroscopy. While fibrils assembled in the presence of salt form flat, striated ribbons, in the absence of salt they formed mainly twisted filaments. To get insights into their structural differences at the atomic level, 3D solid-state NMR spectra on both fibril types were acquired allowing the detection of the differences in chemical shifts of 13C and 15N atoms in both preparations...
January 11, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28074530/slice-profile-and-b1-corrections-in-2d-magnetic-resonance-fingerprinting
#2
Dan Ma, Simone Coppo, Yong Chen, Debra F McGivney, Yun Jiang, Shivani Pahwa, Vikas Gulani, Mark A Griswold
PURPOSE: The goal of this study is to characterize and improve the accuracy of 2D magnetic resonance fingerprinting (MRF) scans in the presence of slice profile (SP) and B1 imperfections, which are two main factors that affect quantitative results in MRF. METHODS: The SP and B1 imperfections are characterized and corrected separately. The SP effect is corrected by simulating the radiofrequency pulse in the dictionary, and the B1 is corrected by acquiring a B1 map using the Bloch-Siegert method before each scan...
January 11, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28050906/gelified-biofluids-for-hrmas-1-h-nmr-analysis-the-case-of-urine
#3
Panteleimon G Takis, Leonardo Tenori, Enrico Ravera, Claudio Luchinat
In this letter we propose an alternative, effective protocol for metabolomic characterization of biofluids based on their gelification and subsequent application of high resolution magic angle spinning (HRMAS) (1)H nuclear magnetic resonance (NMR). The sample handling is very rapid and reproducible, and much less than 40 μl of neat urine are needed to obtain a sample. Our results indicate that the HRMAS spectra of gelified urine encompass all metabolites in the NMR fingerprint, as observed by solution NMR...
January 3, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28043909/magnetic-resonance-fingerprinting-based-on-realistic-vasculature-in-mice
#4
Philippe Pouliot, Louis Gagnon, Tina Lam, Pramod K Avti, Chris Bowen, Michèle Desjardins, Ashok K Kakkar, E Thorin, Sava Sakadzic, David A Boas, Frédéric Lesage
Magnetic resonance fingerprinting (MRF) was recently proposed as a novel strategy for MR data acquisition and analysis. A variant of MRF called vascular MRF (vMRF) followed, that extracted maps of three parameters of physiological importance: cerebral oxygen saturation (SatO2), mean vessel radius and cerebral blood volume (CBV). However, this estimation was based on idealized 2-dimensional simulations of vascular networks using random cylinders and the empirical Bloch equations convolved with a diffusion kernel...
December 30, 2016: NeuroImage
https://www.readbyqxmd.com/read/28019022/use-of-pattern-recognition-for-unaliasing-simultaneously-acquired-slices-in-simultaneous-multislice-mr-fingerprinting
#5
Yun Jiang, Dan Ma, Himanshu Bhat, Huihui Ye, Stephen F Cauley, Lawrence L Wald, Kawin Setsompop, Mark A Griswold
PURPOSE: The purpose of this study is to accelerate an MR fingerprinting (MRF) acquisition by using a simultaneous multislice method. METHODS: A multiband radiofrequency (RF) pulse was designed to excite two slices with different flip angles and phases. The signals of two slices were driven to be as orthogonal as possible. The mixed and undersampled MRF signal was matched to two dictionaries to retrieve T1 and T2 maps of each slice. Quantitative results from the proposed method were validated with the gold-standard spin echo methods in a phantom...
December 26, 2016: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28019021/multiparametric-estimation-of-brain-hemodynamics-with-mr-fingerprinting-asl
#6
Pan Su, Deng Mao, Peiying Liu, Yang Li, Marco C Pinho, Babu G Welch, Hanzhang Lu
PURPOSE: Assessment of brain hemodynamics without exogenous contrast agents is of increasing importance in clinical applications. This study aims to develop an MR perfusion technique that can provide noncontrast and multiparametric estimation of hemodynamic markers. METHODS: We devised an arterial spin labeling (ASL) method based on the principle of MR fingerprinting (MRF), referred to as MRF-ASL. By taking advantage of the rich information contained in MRF sequence, up to seven hemodynamic parameters can be estimated concomitantly...
December 26, 2016: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/27986172/magnetic-resonance-imaging-of-liver-metastasis
#7
Ali Devrim Karaosmanoglu, Mehmet Ruhi Onur, Mustafa Nasuh Ozmen, Deniz Akata, Musturay Karcaaltincaba
Liver magnetic resonance imaging (MRI) is becoming the gold standard in liver metastasis detection and treatment response assessment. The most sensitive magnetic resonance sequences are diffusion-weighted images and hepatobiliary phase images after Gd-EOB-DTPA. Peripheral ring enhancement, diffusion restriction, and hypointensity on hepatobiliary phase images are hallmarks of liver metastases. In patients with normal ultrasonography, computed tomography (CT), and positron emission tomography (PET)-CT findings and high clinical suspicion of metastasis, MRI should be performed for diagnosis of unseen metastasis...
December 2016: Seminars in Ultrasound, CT, and MR
https://www.readbyqxmd.com/read/27981641/magnetic-resonance-fingerprinting-using-echo-planar-imaging-joint-quantification-of-t1-and-t2%C3%A2-relaxation-times
#8
Benedikt Rieger, Fabian Zimmer, Jascha Zapp, Sebastian Weingärtner, Lothar R Schad
PURPOSE: To develop an implementation of the magnetic resonance fingerprinting (MRF) paradigm for quantitative imaging using echo-planar imaging (EPI) for simultaneous assessment of T1 and T2∗. METHODS: The proposed MRF method (MRF-EPI) is based on the acquisition of 160 gradient-spoiled EPI images with rapid, parallel-imaging accelerated, Cartesian readout and a measurement time of 10 s per slice. Contrast variation is induced using an initial inversion pulse, and varying the flip angles, echo times, and repetition times throughout the sequence...
December 16, 2016: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/27937040/multiparametric-or-practical-quantitative-liver-mri-towards-millisecond-fat-fraction-kilopascal-and-function-era
#9
Emre Unal, Ilkay Sedakat Idilman, Muşturay Karçaaltıncaba
New advances in liver magnetic resonance imaging (MRI) may enable diagnosis of unseen pathologies by conventional techniques. Normal T1 (550-620 ms for 1.5 T and 700-850 ms for 3 T), T2, T2* (>20 ms), T1rho (40-50 ms) mapping, proton density fat fraction (PDFF) (≤5%) and stiffness (2-3kPa) values can enable differentiation of a normal liver from chronic liver and diffuse diseases. Gd-EOB-DTPA can enable assessment of liver function by using postcontrast hepatobiliary phase or T1 reduction rate (normally above 60%)...
February 2017: Expert Review of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/27929400/a-systematic-evaluation-of-blood-serum-and-plasma-pre-analytics-for-metabolomics-cohort-studies
#10
Elodie Jobard, Olivier Trédan, Déborah Postoly, Fabrice André, Anne-Laure Martin, Bénédicte Elena-Herrmann, Sandrine Boyault
The recent thriving development of biobanks and associated high-throughput phenotyping studies requires the elaboration of large-scale approaches for monitoring biological sample quality and compliance with standard protocols. We present a metabolomic investigation of human blood samples that delineates pitfalls and guidelines for the collection, storage and handling procedures for serum and plasma. A series of eight pre-processing technical parameters is systematically investigated along variable ranges commonly encountered across clinical studies...
December 5, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27889428/spectroscopic-and-e-tongue-evaluation-of-medicinal-plants-a-taste-of-how-rasa-can-be-studied
#11
Rama Jayasundar, Somenath Ghatak
BACKGROUND: The use of medicinal plants in Ayurveda is based on rasa, generally taken to represent taste as a sensory perception. This chemosensory parameter plays an important role in Ayurvedic pharmacology. OBJECTIVE: The aim is to explore the use of structuro-functional information deduced from analytical techniques for the rasa-based classification of medicinal plants in Ayurveda. MATERIALS AND METHODS: Methods of differential sensing and spectroscopic metabolomics have been used in select medicinal plants from three different taste categories (sweet, pungent and multiple taste): Tribulus terrestris, Vitis vinifera and Glycyrrhiza glabra from sweet category; Piper longum, Cuminum cyminum and Capsicum annum from pungent group; Emblica officinalis with five tastes...
October 2016: Journal of Ayurveda and Integrative Medicine
https://www.readbyqxmd.com/read/27851871/robust-sliding-window-reconstruction-for-accelerating-the-acquisition-of-mr-fingerprinting
#12
Xiaozhi Cao, Congyu Liao, Zhixing Wang, Ying Chen, Huihui Ye, Hongjian He, Jianhui Zhong
PURPOSE: To develop a method for accelerated and robust MR fingerprinting (MRF) with improved image reconstruction and parameter matching processes. THEORY AND METHODS: A sliding-window (SW) strategy was applied to MRF, in which signal and dictionary matching was conducted between fingerprints consisting of mixed-contrast image series reconstructed from consecutive data frames segmented by a sliding window, and a precalculated mixed-contrast dictionary. The effectiveness and performance of this new method, dubbed SW-MRF, was evaluated in both phantom and in vivo...
November 7, 2016: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/27834866/staphylococcus-aureus-infection-reduces-nutrition-uptake-and-nucleotide-biosynthesis-in-a-human-airway-epithelial-cell-line
#13
Philipp Gierok, Manuela Harms, Karen Methling, Falko Hochgräfe, Michael Lalk
The Gram positive opportunistic human pathogen Staphylococcus aureus induces a variety of diseases including pneumonia. S. aureus is the second most isolated pathogen in cystic fibrosis patients and accounts for a large proportion of nosocomial pneumonia. Inside the lung, the human airway epithelium is the first line in defence with regard to microbial recognition and clearance as well as regulation of the immune response. The metabolic host response is, however, yet unknown. To address the question of whether the infection alters the metabolome and metabolic activity of airway epithelial cells, we used a metabolomics approach...
November 9, 2016: Metabolites
https://www.readbyqxmd.com/read/27829500/a-serum-nuclear-magnetic-resonance-based-metabolomic-signature-of-antiphospholipid-syndrome
#14
Angelica Palisi, Manuela Grimaldi, Paola Sabatini, Paola Montoro, Mario Scrima, Manuela Rodriquez, Anna Maria D'Ursi
Antiphospholipid syndrome (APS) is a rheumatic inflammatory chronic autoimmune disease inducing hypercoagulable state associated with vascular thrombosis and pregnancy loss in women. Cardiac, cerebral and vascular strokes in these patients are responsible for reduction in life expectancy. Timely diagnosis and accurate monitoring of disease are decisive to improve the accuracy of therapy. In the present work, we present a NMR-based metabolomic study of blood sera of APS patients. Our data show that individuals suffering APS have a characteristic metabolomic profile with abnormalities associated to the metabolism of methyl group donors, ketone bodies and amino acids...
January 30, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/27824358/you-say-prefrontal-cortex-and-i-say-anterior-cingulate-meta-analysis-of-spatial-overlap-in-amygdala-to-prefrontal-connectivity-and-internalizing-symptomology
#15
H A Marusak, M E Thomason, C Peters, C Zundel, F Elrahal, C A Rabinak
Connections between the amygdala and medial prefrontal cortex (mPFC) are considered critical for the expression and regulation of emotional behavior. Abnormalities in frontoamygdala circuitry are reported across several internalizing conditions and associated risk factors (for example, childhood trauma), which may underlie the strong phenotypic overlap and co-occurrence of internalizing conditions. However, it is unclear if these findings converge on the same localized areas of mPFC or adjacent anterior cingulate cortex (ACC)...
November 8, 2016: Translational Psychiatry
https://www.readbyqxmd.com/read/27790751/repeatability-of-magnetic-resonance-fingerprinting-t1-and-t2-estimates-assessed-using-the-ismrm-nist-mri-system-phantom
#16
Yun Jiang, Dan Ma, Kathryn E Keenan, Karl F Stupic, Vikas Gulani, Mark A Griswold
PURPOSE: The purpose of this study was to evaluate accuracy and repeatability of T1 and T2 estimates of a MR fingerprinting (MRF) method using the ISMRM/NIST MRI system phantom. METHODS: The ISMRM/NIST MRI system phantom contains multiple compartments with standardized T1 , T2 , and proton density values. Conventional inversion-recovery spin echo and spin echo methods were used to characterize the T1 and T2 values in the phantom. The phantom was scanned using the MRF-FISP method over 34 consecutive days...
October 27, 2016: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/27777928/cervicovaginal-fluid-acetate-a-metabolite-marker-of-preterm-birth-in-symptomatic-pregnant-women
#17
Emmanuel Amabebe, Steven Reynolds, Victoria Stern, Graham Stafford, Martyn Paley, Dilly O C Anumba
Changes in vaginal microbiota that is associated with preterm birth (PTB) leave specific metabolite fingerprints that can be detected in the cervicovaginal fluid (CVF) using metabolomics techniques. In this study, we characterize and validate the CVF metabolite profile of pregnant women presenting with symptoms of threatened preterm labor (PTL) by both (1)H-nuclear magnetic resonance spectroscopy (NMR) and enzyme-based spectrophotometry. We also determine their predictive capacity for PTB, singly, and in combination, with current clinical screening tools - cervicovaginal fetal fibronectin (FFN) and ultrasound cervical length (CL)...
2016: Frontiers in Medicine
https://www.readbyqxmd.com/read/27765209/cultivar-classification-of-apulian-olive-oils-use-of-artificial-neural-networks-for-comparing-nmr-nir-and-merceological-data
#18
Giulio Binetti, Laura Del Coco, Rosa Ragone, Samanta Zelasco, Enzo Perri, Cinzia Montemurro, Raffaele Valentini, David Naso, Francesco Paolo Fanizzi, Francesco Paolo Schena
The development of an efficient and accurate method for extra-virgin olive oils cultivar and origin authentication is complicated by the broad range of variables (e.g., multiplicity of varieties, pedo-climatic aspects, production and storage conditions) influencing their properties. In this study, artificial neural networks (ANNs) were applied on several analytical datasets, namely standard merceological parameters, near-infra red data and (1)H nuclear magnetic resonance (NMR) fingerprints, obtained on mono-cultivar olive oils of four representative Apulian varieties (Coratina, Ogliarola, Cima di Mola, Peranzana)...
March 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/27760442/metabolomics-guided-isolation-of-anti-trypanosomal-metabolites-from-the-endophytic-fungus-lasiodiplodia-theobromae
#19
Nurkhalida Kamal, Christina V Viegelmann, Carol J Clements, RuAngelie Edrada-Ebel
Fungal endophytes offer diverse and unique secondary metabolites, making these organisms potential sources of promising drug leads. The application of high-resolution-liquid chromatography mass spectrometry and nuclear magnetic resonance-based metabolomics to fungal endophytes is practical in terms of dereplication studies and the mining of bioactive compounds. In this paper, we report the application of metabolomics in parallel with anti-trypanosomal assays to determine the ideal conditions for the medium-scale fermentation of the endophyte Lasiodiplodia theobromae...
October 19, 2016: Planta Medica
https://www.readbyqxmd.com/read/27746236/coexistence-of-obesity-and-asthma-determines-a-distinct-respiratory-metabolic-phenotype
#20
Mauro Maniscalco, Debora Paris, Dominique J Melck, Maria D'Amato, Anna Zedda, Matteo Sofia, Cristiana Stellato, Andrea Motta
BACKGROUND: Epidemiologic and clinical evidence supports the existence of an obesity-related asthma phenotype. No distinct pathophysiologic elements or specific biomarkers have been identified thus far, but increased oxidative stress has been reported. OBJECTIVE: We aimed at verifying whether metabolomics of exhaled breath condensate from obese asthmatic (OA) patients, lean asthmatic (LA) patients, and obese nonasthmatic (ONA) subjects could recognize specific and statistically validated biomarkers for a separate "asthma-obesity" respiratory metabolic phenotype, here defined as "metabotype...
October 14, 2016: Journal of Allergy and Clinical Immunology
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