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magnetic resonance fingerprinting

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https://www.readbyqxmd.com/read/28333946/structural-and-functional-connectional-fingerprints-in-mild-cognitive-impairment-and-alzheimer-s-disease-patients
#1
Seong-Jin Son, Jonghoon Kim, Hyunjin Park
Regional volume atrophy and functional degeneration are key imaging hallmarks of Alzheimer's disease (AD) in structural and functional magnetic resonance imaging (MRI), respectively. We jointly explored regional volume atrophy and functional connectivity to better characterize neuroimaging data of AD and mild cognitive impairment (MCI). All data were obtained from the Alzheimer's Disease Neuroimaging Initiative (ADNI) database. We compared regional volume atrophy and functional connectivity in 10 subcortical regions using structural MRI and resting-state functional MRI (rs-fMRI)...
2017: PloS One
https://www.readbyqxmd.com/read/28328013/validation-of-surface-to-volume-ratio-measurements-derived-from-oscillating-gradient-spin-echo-on-a-clinical-scanner-using-anisotropic-fiber-phantoms
#2
Gregory Lemberskiy, Steven H Baete, Martijn A Cloos, Dmitry S Novikov, Els Fieremans
A diffusion measurement in the short-time surface-to-volume ratio (S/V) limit (Mitra et al., Phys Rev Lett. 1992;68:3555) can disentangle the free diffusion coefficient from geometric restrictions to diffusion. Biophysical parameters, such as the S/V of tissue membranes, can be used to estimate microscopic length scales non-invasively. However, due to gradient strength limitations on clinical MRI scanners, pulsed gradient spin echo (PGSE) measurements are impractical for probing the S/V limit. To achieve this limit on clinical systems, an oscillating gradient spin echo (OGSE) sequence was developed...
March 22, 2017: NMR in Biomedicine
https://www.readbyqxmd.com/read/28326027/accessible-neurobehavioral-anger-related-markers-for-vulnerability-to-post-traumatic-stress-symptoms-in-a-population-of-male-soldiers
#3
Tamar Lin, Gadi Gilam, Gal Raz, Ayelet Or-Borichev, Yair Bar-Haim, Eyal Fruchter, Talma Hendler
Identifying vulnerable individuals prone to develop post-traumatic stress symptoms (PTSS) is of paramount importance, especially in populations at high risk for stress exposure such as combat soldiers. While several neural and psychological risk factors are known, no post-traumatic stress disorder (PTSD) biomarker has yet progressed to clinical use. Here we present novel and clinically applicable anger-related neurobehavioral risk markers for military-related PTSS in a large cohort of Israeli soldiers. The psychological, electrophysiological and neural (Simultaneous recording of scalp electroencephalography [EEG] and functional magnetic resonance imaging [fMRI]) reaction to an anger-inducing film were measured prior to advanced military training and PTSS were recorded at 1-year follow-up...
2017: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/28296209/the-urinary-1-h-nmr-metabolomics-profile-of-an-italian-autistic-children-population-and-their-unaffected-siblings
#4
Milena Lussu, Antonio Noto, Alice Masili, Andrea C Rinaldi, Angelica Dessì, Maria De Angelis, Andrea De Giacomo, Vassilios Fanos, Luigi Atzori, Ruggiero Francavilla
Autism spectrum disorders (ASD) make a dishomogeneous group of psychiatric diseases having either genetic and environmental components, including changes of the microbiota. The rate of diagnosis, based on a series of psychological tests and observed behavior, dramatically increased in the past few decades. Currently, no biological markers are available and the pathogenesis is not defined. The purpose of this study was to evaluate the potential use of (1) H-NMR metabolomics to analyze the global biochemical signature of ASD patients (n = 21) and controls (n = 21), these being siblings of autistic patients...
March 11, 2017: Autism Research: Official Journal of the International Society for Autism Research
https://www.readbyqxmd.com/read/28268369/optimal-experiment-design-for-magnetic-resonance-fingerprinting
#5
Bo Zhao, Justin P Haldar, Kawin Setsompop, Lawrence L Wald
Magnetic resonance (MR) fingerprinting is an emerging quantitative MR imaging technique that simultaneously acquires multiple tissue parameters in an efficient experiment. In this work, we present an estimation-theoretic framework to evaluate and design MR fingerprinting experiments. More specifically, we derive the Cramér-Rao bound (CRB), a lower bound on the covariance of any unbiased estimator, to characterize parameter estimation for MR fingerprinting. We then formulate an optimal experiment design problem based on the CRB to choose a set of acquisition parameters (e...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28268366/low-rank-magnetic-resonance-fingerprinting
#6
Gal Mazor, Lior Weizman, Assaf Tal, Yonina C Eldar
Magnetic Resonance Fingerprinting (MRF) is a relatively new approach that provides quantitative MRI using randomized acquisition. Extraction of physical quantitative tissue values is preformed off-line, based on acquisition with varying parameters and a dictionary generated according to the Bloch equations. MRF uses hundreds of radio frequency (RF) excitation pulses for acquisition, and therefore high under-sampling ratio in the sampling domain (k-space) is required. This under-sampling causes spatial artifacts that hamper the ability to accurately estimate the quantitative tissue values...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28267626/bayesian-switching-factor-analysis-for-estimating-time-varying-functional-connectivity-in-fmri
#7
Jalil Taghia, Srikanth Ryali, Tianwen Chen, Kaustubh Supekar, Weidong Cai, Vinod Menon
There is growing interest in understanding the dynamical properties of functional interactions between distributed brain regions. However, robust estimation of temporal dynamics from functional magnetic resonance imaging (fMRI) data remains challenging due to limitations in extant multivariate methods for modeling time-varying functional interactions between multiple brain areas. Here, we develop a Bayesian generative model for fMRI time-series within the framework of hidden Markov models (HMMs). The model is a dynamic variant of the static factor analysis model (Ghahramani and Beal, 2000)...
March 3, 2017: NeuroImage
https://www.readbyqxmd.com/read/28261851/low-rank-alternating-direction-method-of-multipliers-reconstruction-for-mr-fingerprinting
#8
Jakob Assländer, Martijn A Cloos, Florian Knoll, Daniel K Sodickson, Jürgen Hennig, Riccardo Lattanzi
PURPOSE: The proposed reconstruction framework addresses the reconstruction accuracy, noise propagation and computation time for magnetic resonance fingerprinting. METHODS: Based on a singular value decomposition of the signal evolution, magnetic resonance fingerprinting is formulated as a low rank (LR) inverse problem in which one image is reconstructed for each singular value under consideration. This LR approximation of the signal evolution reduces the computational burden by reducing the number of Fourier transformations...
March 5, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28229920/in-vitro-wound-healing-and-cytotoxic-activity-of-the-gel-and-whole-leaf-materials-from-selected-aloe-species
#9
Lizelle T Fox, Anisha Mazumder, Anupma Dwivedi, Minja Gerber, Jeanetta du Plessis, Josias H Hamman
ETHNOPHARMACOLOGICAL RELEVANCE: Aloe vera is one of the most important medicinal plants in the world with applications in the cosmetic industry and also in the tonic or health drink product market. Different parts of Aloe ferox and Aloe marlothii are used as traditional medicines for different applications. Although wound healing has been shown for certain aloe gel materials (e.g. A. vera) previously, there are conflicting reports on this medicinal application of aloe leaf gel materials...
February 13, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28226533/optimal-experiment-design-for-magnetic-resonance-fingerprinting
#10
Bo Zhao, Justin P Haldar, Kawin Setsompop, Lawrence L Wald, Bo Zhao, Justin P Haldar, Kawin Setsompop, Lawrence L Wald, Bo Zhao, Lawrence L Wald, Justin P Haldar, Kawin Setsompop
Magnetic resonance (MR) fingerprinting is an emerging quantitative MR imaging technique that simultaneously acquires multiple tissue parameters in an efficient experiment. In this work, we present an estimation-theoretic framework to evaluate and design MR fingerprinting experiments. More specifically, we derive the Cramér-Rao bound (CRB), a lower bound on the covariance of any unbiased estimator, to characterize parameter estimation for MR fingerprinting. We then formulate an optimal experiment design problem based on the CRB to choose a set of acquisition parameters (e...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226530/low-rank-magnetic-resonance-fingerprinting
#11
Gal Mazor, Lior Weizman, Assaf Tal, Yonina C Eldar, Gal Mazor, Lior Weizman, Assaf Tal, Yonina C Eldar, Gal Mazor, Assaf Tal, Lior Weizman, Yonina C Eldar
Magnetic Resonance Fingerprinting (MRF) is a relatively new approach that provides quantitative MRI using randomized acquisition. Extraction of physical quantitative tissue values is preformed off-line, based on acquisition with varying parameters and a dictionary generated according to the Bloch equations. MRF uses hundreds of radio frequency (RF) excitation pulses for acquisition, and therefore high under-sampling ratio in the sampling domain (k-space) is required. This under-sampling causes spatial artifacts that hamper the ability to accurately estimate the quantitative tissue values...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28223063/matrix-completion-based-reconstruction-for-undersampled-magnetic-resonance-fingerprinting-data
#12
Mariya Doneva, Thomas Amthor, Peter Koken, Karsten Sommer, Peter Börnert
An iterative reconstruction method for undersampled magnetic resonance fingerprinting data is presented. The method performs the reconstruction entirely in k-space and is related to low rank matrix completion methods. A low dimensional data subspace is estimated from a small number of k-space locations fully sampled in the temporal direction and used to reconstruct the missing k-space samples before MRF dictionary matching. Performing the iterations in k-space eliminates the need for applying a forward and an inverse Fourier transform in each iteration required in previously proposed iterative reconstruction methods for undersampled MRF data...
February 18, 2017: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/28188914/connectivity-based-parcellation-reveals-distinct-cortico-striatal-connectivity-fingerprints-in-autism-spectrum-disorder
#13
Joshua H Balsters, Dante Mantini, Nicole Wenderoth
Autism Spectrum Disorder (ASD) has been associated with abnormal synaptic development causing a breakdown in functional connectivity. However, when measured at the macro scale using resting state fMRI, these alterations are subtle and often difficult to detect due to the large heterogeneity of the pathology. Recently, we outlined a novel approach for generating robust biomarkers of resting state functional magnetic resonance imaging (RS-fMRI) using connectivity based parcellation of gross morphological structures to improve single-subject reproducibility and generate more robust connectivity fingerprints...
February 7, 2017: NeuroImage
https://www.readbyqxmd.com/read/28187264/development-of-a-combined-mr-fingerprinting-and-diffusion-examination-for-prostate-cancer
#14
Alice C Yu, Chaitra Badve, Lee E Ponsky, Shivani Pahwa, Sara Dastmalchian, Matthew Rogers, Yun Jiang, Seunghee Margevicius, Mark Schluchter, William Tabayoyong, Robert Abouassaly, Debra McGivney, Mark A Griswold, Vikas Gulani
Purpose To develop and evaluate an examination consisting of magnetic resonance (MR) fingerprinting-based T1, T2, and standard apparent diffusion coefficient (ADC) mapping for multiparametric characterization of prostate disease. Materials and Methods This institutional review board-approved, HIPAA-compliant retrospective study of prospectively collected data included 140 patients suspected of having prostate cancer. T1 and T2 mapping was performed with fast imaging with steady-state precession-based MR fingerprinting with ADC mapping...
February 10, 2017: Radiology
https://www.readbyqxmd.com/read/28177875/metabolomic-signature-associated-with-reproduction-regulated-aging-in-caenorhabditis-elegans
#15
Qin-Li Wan, Xiaohuo Shi, Jiangxin Liu, Ai-Jun Ding, Yuan-Zhu Pu, Zhigang Li, Gui-Sheng Wu, Huai-Rong Luo
In Caenorhabditis elegans (C. elegans), ablation of germline stem cells (GSCs) leads to infertility, which extends lifespan. It has been reported that aging and reproduction are both inextricably associated with metabolism. However, few studies have investigated the roles of polar small molecules metabolism in regulating longevity by reproduction. In this work, we combined the nuclear magnetic resonance (NMR) and ultra-performance liquid chromatography-mass spectrometry (UPLC-MS) to profile the water-soluble metabolome in C...
February 6, 2017: Aging
https://www.readbyqxmd.com/read/28107809/plasma-protein-profiling-for-potential-biomarkers-in-the-early-diagnosis-of-alzheimer-s-disease
#16
Yuki Kitamura, Ryoko Usami, Sahoko Ichihara, Hirotaka Kida, Masayuki Satoh, Hidekazu Tomimoto, Mariko Murata, Shinji Oikawa
OBJECTIVES: Alzheimer's disease (AD) is the most common cause of dementia in elderly persons. Since the pathology of AD develops slowly from a preclinical or early phase into a fully expressed clinical syndrome, at the time of diagnosis the disease has been progressing for many years. To facilitate the early diagnosis of AD, we performed protein profiling of blood in patients with mild AD as defined by the Functional Assessment Staging (FAST) scale. METHODS: Plasma samples from mild AD patients and healthy controls were analyzed using two-dimensional differential gel electrophoresis (2D-DIGE) combined with matrix-assisted laser desorption ionization time-of-flight tandem mass spectrometry (MALDI-TOF/TOF/MS) followed by peptide mass fingerprinting...
March 2017: Neurological Research
https://www.readbyqxmd.com/read/28103873/masquelier-s-grape-seed-extract-from-basic-flavonoid-research-to-a-well-characterized-food-supplement-with-health-benefits
#17
REVIEW
Antje R Weseler, Aalt Bast
Careful characterization and standardization of the composition of plant-derived food supplements is essential to establish a cause-effect relationship between the intake of that product and its health effect. In this review we follow a specific grape seed extract containing monomeric and oligomeric flavan-3-ols from its creation by Jack Masquelier in 1947 towards a botanical remedy and nutraceutical with proven health benefits. The preparation's research history parallels the advancing insights in the fields of molecular biology, medicine, plant and nutritional sciences during the last 70 years...
January 19, 2017: Nutrition Journal
https://www.readbyqxmd.com/read/28075583/amyloid-fibril-polymorphism-almost-identical-on-the-atomic-level-mesoscopically-very-different
#18
Carolin Seuring, Joeri Verasdonck, Philippe Ringler, Riccardo Cadalbert, Henning Stahlberg, Anja Böckmann, Beat H Meier, Roland Riek
Amyloid polymorphism of twisted and straight β-endorphin fibrils was studied by negative-stain transmission electron microscopy, scanning transmission electron microscopy, and solid-state nuclear magnetic resonance spectroscopy. Whereas fibrils assembled in the presence of salt formed flat, striated ribbons, in the absence of salt they formed mainly twisted filaments. To get insights into their structural differences at the atomic level, 3D solid-state NMR spectra of both fibril types were acquired, allowing the detection of the differences in chemical shifts of (13)C and (15)N atoms in both preparations...
February 20, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28074530/slice-profile-and-b1-corrections-in-2d-magnetic-resonance-fingerprinting
#19
Dan Ma, Simone Coppo, Yong Chen, Debra F McGivney, Yun Jiang, Shivani Pahwa, Vikas Gulani, Mark A Griswold
PURPOSE: The goal of this study is to characterize and improve the accuracy of 2D magnetic resonance fingerprinting (MRF) scans in the presence of slice profile (SP) and B1 imperfections, which are two main factors that affect quantitative results in MRF. METHODS: The SP and B1 imperfections are characterized and corrected separately. The SP effect is corrected by simulating the radiofrequency pulse in the dictionary, and the B1 is corrected by acquiring a B1 map using the Bloch-Siegert method before each scan...
January 11, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28050906/gelified-biofluids-for-hrmas-1-h-nmr-analysis-the-case-of-urine
#20
Panteleimon G Takis, Leonardo Tenori, Enrico Ravera, Claudio Luchinat
In this letter we propose an alternative, effective protocol for metabolomic characterization of biofluids based on their gelification and subsequent application of high resolution magic angle spinning (HRMAS) (1)H nuclear magnetic resonance (NMR). The sample handling is very rapid and reproducible, and much less than 40 μl of neat urine are needed to obtain a sample. Our results indicate that the HRMAS spectra of gelified urine encompass all metabolites in the NMR fingerprint, as observed by solution NMR...
January 3, 2017: Analytical Chemistry
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