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magnetic resonance fingerprinting

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https://www.readbyqxmd.com/read/29756286/rapid-and-quantitative-chemical-exchange-saturation-transfer-cest-imaging-with-magnetic-resonance-fingerprinting-mrf
#1
Ouri Cohen, Shuning Huang, Michael T McMahon, Matthew S Rosen, Christian T Farrar
PURPOSE: To develop a fast magnetic resonance fingerprinting (MRF) method for quantitative chemical exchange saturation transfer (CEST) imaging. METHODS: We implemented a CEST-MRF method to quantify the chemical exchange rate and volume fraction of the Nα -amine protons of L-arginine (L-Arg) phantoms and the amide and semi-solid exchangeable protons of in vivo rat brain tissue. L-Arg phantoms were made with different concentrations (25-100 mM) and pH (pH 4-6)...
May 13, 2018: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29744935/fast-magnetic-resonance-fingerprinting-for-dynamic-contrast-enhanced-studies-in-mice
#2
Yuning Gu, Charlie Y Wang, Christian E Anderson, Yuchi Liu, He Hu, Mette L Johansen, Dan Ma, Yun Jiang, Ciro Ramos-Estebanez, Susann Brady-Kalnay, Mark A Griswold, Chris A Flask, Xin Yu
PURPOSE: The goal of this study was to develop a fast MR fingerprinting (MRF) method for simultaneous T1 and T2 mapping in DCE-MRI studies in mice. METHODS: The MRF sequences based on balanced SSFP and fast imaging with steady-state precession were implemented and evaluated on a 7T preclinical scanner. The readout used a zeroth-moment-compensated variable-density spiral trajectory that fully sampled the entire k-space and the inner 10 × 10 k-space with 48 and 4 interleaves, respectively...
May 9, 2018: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29743863/metabolic-fingerprinting-of-joint-tissue-of-collagen-induced-arthritis-cia-rat-in-vitro-high-resolution-nmr-nuclear-magnetic-resonance-spectroscopy-based-analysis
#3
Niraj Kumar Srivastava, Shikha Sharma, Rajkumar Sharma, Neeraj Sinha, Sudhir Kumar Mandal, Deepak Sharma
Rheumatoid arthritis (RA) is a systemic autoimmune disease whose major characteristics persistent joint inflammation that results in joint destruction and failure of the function. Collagen-induced arthritis (CIA) rat is an autoimmune disease model and in many ways shares features with RA. The CIA is associated with systemic manifestations, including alterations in the metabolism. Nuclear magnetic resonance (NMR) spectroscopy-based metabolomics has been successfully applied to the perchloric acid extract of the joint tissue of CIA rat and control rat for the analysis of aqueous metabolites...
2018: EXCLI Journal
https://www.readbyqxmd.com/read/29703978/time-efficient-whole-brain-coverage-with-mr-fingerprinting-using-slice-interleaved-echo-planar-imaging
#4
Benedikt Rieger, Mehmet Akçakaya, José C Pariente, Sara Llufriu, Eloy Martinez-Heras, Sebastian Weingärtner, Lothar R Schad
Magnetic resonance fingerprinting (MRF) is a promising method for fast simultaneous quantification of multiple tissue parameters. The objective of this study is to improve the coverage of MRF based on echo-planar imaging (MRF-EPI) by using a slice-interleaved acquisition scheme. For this, the MRF-EPI is modified to acquire several slices in a randomized interleaved manner, increasing the effective repetition time of the spoiled gradient echo readout acquisition in each slice. Per-slice matching of the signal-trace to a precomputed dictionary allows the generation of T1 and T2 * maps with integrated B1 + correction...
April 27, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29702604/spectroscopic-chemical-fingerprint-and-biostimulant-activity-of-a-protein-based-product-in-solid-form
#5
Andrea Ertani, Ornella Francioso, Erika Ferrari, Michela Schiavon, Serenella Nardi
A solid biostimulant (AA309) obtained through thermobaric hydrolysis applied on trimmings and shavings of bovine hides tanned with wet-blue technology was chemically characterized, and its effects in maize ( Zea mays L.) were evaluated. AA309 contained 13.60% total nitrogen (N), mainly in organic forms (13.40%), and several amino acids, especially lysine, phenylalanine, glycine, aspartate, and isoleucine. AA309 was further analyzed using Fourier Transform Infrared (FT-IR) spectroscopy, which revealed the presence of amide I and amide II bands, indicative of peptide structures...
April 27, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29624736/mr-fingerprinting-deep-reconstruction-network-drone
#6
Ouri Cohen, Bo Zhu, Matthew S Rosen
PURPOSE: Demonstrate a novel fast method for reconstruction of multi-dimensional MR fingerprinting (MRF) data using deep learning methods. METHODS: A neural network (NN) is defined using the TensorFlow framework and trained on simulated MRF data computed with the extended phase graph formalism. The NN reconstruction accuracy for noiseless and noisy data is compared to conventional MRF template matching as a function of training data size and is quantified in simulated numerical brain phantom data and International Society for Magnetic Resonance in Medicine/National Institute of Standards and Technology phantom data measured on 1...
April 6, 2018: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29545215/estimation-of-perfusion-properties-with-mr-fingerprinting-arterial-spin-labeling
#7
Katherine L Wright, Yun Jiang, Dan Ma, Douglas C Noll, Mark A Griswold, Vikas Gulani, Luis Hernandez-Garcia
In this study, the acquisition of ASL data and quantification of multiple hemodynamic parameters was explored using a Magnetic Resonance Fingerprinting (MRF) approach. A pseudo-continuous ASL labeling scheme was used with pseudo-randomized timings to acquire the MRF ASL data in a 2.5 min acquisition. A large dictionary of MRF ASL signals was generated by combining a wide range of physical and hemodynamic properties with the pseudo-random MRF ASL sequence and a two-compartment model. The acquired signals were matched to the dictionary to provide simultaneous quantification of cerebral blood flow, tissue time-to-peak, cerebral blood volume, arterial time-to-peak, B1 , and T1...
March 12, 2018: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/29531533/metabolic-heterogeneity-evidenced-by-mrs-among-patient-derived-glioblastoma-multiforme-stem-like-cells-accounts-for-cell-clustering-and-different-responses-to-drugs
#8
Sveva Grande, Alessandra Palma, Lucia Ricci-Vitiani, Anna Maria Luciani, Mariachiara Buccarelli, Mauro Biffoni, Agnese Molinari, Annarica Calcabrini, Emanuela D'Amore, Laura Guidoni, Roberto Pallini, Vincenza Viti, Antonella Rosi
Clustering of patient-derived glioma stem-like cells (GSCs) through unsupervised analysis of metabolites detected by magnetic resonance spectroscopy (MRS) evidenced three subgroups, namely clusters 1a and 1b, with high intergroup similarity and neural fingerprints, and cluster 2, with a metabolism typical of commercial tumor lines. In addition, subclones generated by the same GSC line showed different metabolic phenotypes. Aerobic glycolysis prevailed in cluster 2 cells as demonstrated by higher lactate production compared to cluster 1 cells...
2018: Stem Cells International
https://www.readbyqxmd.com/read/29510542/%C3%A2-h-nmr-profiling-and-chemometric-analysis-of-selected-honeys-from-south-africa-zambia-and-slovakia
#9
Emmanuel O Olawode, Roman Tandlich, Garth Cambray
Honey is the natural sweet substance produced by honeybee from nectar or honeydew, exhibiting several nutritional and health benefits. It contains a complex mixture of compounds in different proportions, with sugars being the main component. The physicochemical characteristics of ten honeys were evaluated; represented by five, three, and two from South Africa, Slovakia, and Zambia, respectively. The range of values for the pH (3.75-4.38), electrical conductivity (99-659 µS/cm), and moisture content (14.2-17...
March 5, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29498849/hsqc-tocsy-fingerprinting-for-prioritization-of-polyketide-and-peptide-producing-microbial-isolates
#10
Larissa Buedenbender, Leesa J Habener, Tanja Grkovic, D İpek Kurtböke, Sandra Duffy, Vicky M Avery, Anthony R Carroll
Microbial products are a promising source for drug leads as a result of their unique structural diversity. However, reisolation of already known natural products significantly hampers the discovery process, and it is therefore important to incorporate effective microbial isolate selection and dereplication protocols early in microbial natural product studies. We have developed a systematic approach for prioritization of microbial isolates for natural product discovery based on heteronuclear single-quantum correlation-total correlation spectroscopy (HSQC-TOCSY) nuclear magnetic resonance profiles in combination with antiplasmodial activity of extracts...
April 27, 2018: Journal of Natural Products
https://www.readbyqxmd.com/read/29477806/metabolite-profiling-of-listeria-innocua-for-unravelling-the-inactivation-mechanism-of-electrolysed-water-by-nuclear-magnetic-resonance-spectroscopy
#11
Qin Liu, Ji'en Wu, Zhi Yang Lim, Shaojuan Lai, Norman Lee, Hongshun Yang
Bactericidal effects of low concentration electrolysed water (LcEW) on microorganisms are previously well reported; however, the inactivation mechanism of EW is not understood. The lethal and sublethal injuries of L. monocytogenes and L. innocua by EW treatments were determined and the metabolic profile changes for L. innocua were characterised using nuclear magnetic resonance (NMR). Microbial metabolomics approach combined with multivariate data analyses was used to interpret the cellular chemical fingerprints of L...
April 20, 2018: International Journal of Food Microbiology
https://www.readbyqxmd.com/read/29409793/brain-mechanisms-underlying-cue-based-memorizing-during-free-viewing-of-movie-memento
#12
Janne Kauttonen, Yevhen Hlushchuk, Iiro P Jääskeläinen, Pia Tikka
How does the human brain recall and connect relevant memories with unfolding events? To study this, we presented 25 healthy subjects, during functional magnetic resonance imaging, the movie 'Memento' (director C. Nolan). In this movie, scenes are presented in chronologically reverse order with certain scenes briefly overlapping previously presented scenes. Such overlapping "key-frames" serve as effective memory cues for the viewers, prompting recall of relevant memories of the previously seen scene and connecting them with the concurrent scene...
May 15, 2018: NeuroImage
https://www.readbyqxmd.com/read/29358016/trimage-a-dedicated-trimodality-pet-mr-eeg-imaging-tool-for-schizophrenia
#13
Alberto Del Guerra, Salleh Ahmad, Mihai Avram, Nicola Belcari, Arne Berneking, Laura Biagi, Maria Giuseppina Bisogni, Felix Brandl, Jorge Cabello, Niccolò Camarlinghi, Piergiorgio Cerello, Chang-Hoon Choi, Silvia Coli, Sabrina Colpo, Julien Fleury, Vito Gagliardi, Giuseppe Giraudo, Karsten Heekeren, Wolfram Kawohl, Theodora Kostou, Jean-Luc Lefaucheur, Christoph Lerche, George Loudos, Matteo Morrocchi, Julien Muller, Mona Mustafa, Irene Neuner, Panagiotis Papadimitroulas, Francesco Pennazio, Ravichandran Rajkumar, Cláudia Régio Brambilla, Julien Rivoire, Elena Rota Kops, Jürgen Scheins, Rémy Schimpf, N Jon Shah, Christian Sorg, Giancarlo Sportelli, Michela Tosetti, Riccardo Trinchero, Christine Wyss, Sibylle Ziegler
Simultaneous PET/MR/EEG (Positron Emission Tomography - Magnetic Resonance - Electroencephalography), a new tool for the investigation of neuronal networks in the human brain, is presented here within the framework of the European Union Project TRIMAGE. The trimodal, cost-effective PET/MR/EEG imaging tool makes use of cutting edge technology both in PET and in MR fields. A novel type of magnet (1.5T, non-cryogenic) has been built together with a PET scanner that makes use of the most advanced photodetectors (i...
April 2018: European Psychiatry: the Journal of the Association of European Psychiatrists
https://www.readbyqxmd.com/read/29350255/nuclear-magnetic-resonance-and-high-performance-liquid-chromatography-techniques-for-the-characterization-of-bioactive-compounds-from-humulus-lupulus-l-hop
#14
Davide Bertelli, Virginia Brighenti, Lucia Marchetti, Anna Reik, Federica Pellati
Humulus lupulus L. (hop) represents one of the most cultivated crops, it being a key ingredient in the brewing process. Many health-related properties have been described for hop extracts, making this plant gain more interest in the field of pharmaceutical and nutraceutical research. Among the analytical tools available for the phytochemical characterization of plant extracts, quantitative nuclear magnetic resonance (qNMR) represents a new and powerful technique. In this ambit, the present study was aimed at the development of a new, simple, and efficient qNMR method for the metabolite fingerprinting of bioactive compounds in hop cones, taking advantage of the novel ERETIC 2 tool...
January 19, 2018: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/29342836/cool-climate-red-wines-chemical-composition-and-comparison-of-two-protocols-for-%C3%A2-h-nmr-analysis
#15
Violetta Aru, Klavs Martin Sørensen, Bekzod Khakimov, Torben Bo Toldam-Andersen, Søren Balling Engelsen
This study investigates the metabolome of 26 experimental cool-climate wines made from 22 grape varieties using two different protocols for wine analysis by proton nuclear magnetic resonance (¹H-NMR) spectroscopy. The wine samples were analyzed as-is (wet) and as dried samples. The NMR datasets were preprocessed by alignment and mean centering. No normalization or scaling was performed. The "wet" method preserved the inherent properties of the samples and provided a fast and effective overview of the molecular composition of the wines...
January 13, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29306396/variable-allelopathy-among-phytoplankton-reflected-in-red-tide-metabolome
#16
Remington X Poulin, Kelsey L Poulson-Ellestad, Jessie S Roy, Julia Kubanek
Harmful algae are known to utilize allelopathy, the release of compounds that inhibit competitors, as a form of interference competition. Competitor responses to allelopathy are species-specific and allelopathic potency of producing algae is variable. In the current study, the biological variability in allelopathic potency was mapped to the underlying chemical variation in the exuded metabolomes of five genetic strains of the red tide dinoflagellate Karenia brevis using 1 H nuclear magnetic resonance (NMR) spectroscopy...
January 2018: Harmful Algae
https://www.readbyqxmd.com/read/29287330/detection-of-counterfeit-brand-spirits-using-1-h-nmr-fingerprints-in-comparison-to-sensory-analysis
#17
Thomas Kuballa, Thomas Hausler, Alex O Okaru, Maria Neufeld, Kennedy O Abuga, Isaac O Kibwage, Jürgen Rehm, Burkhard Luy, Stephan G Walch, Dirk W Lachenmeier
Beverage fraud involving counterfeiting of brand spirits is an increasing problem not only due to deception of the consumer but also because it poses health risks e.g. from possible methanol admixture. Suspicious spirit samples from Russia and Kenya were analysed using1 H nuclear magnetic resonance (NMR) spectroscopy in comparison to authentic products. Using linear regression analysis of spectral integral values, 4 counterfeited samples from Russia and 2 from Kenya were easily identifiable with R2  < 0...
April 15, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29285295/nmr-based-metabolomic-techniques-identify-potential-urinary-biomarkers-for-early-colorectal-cancer-detection
#18
Zhening Wang, Yan Lin, Jiahao Liang, Yao Huang, Changchun Ma, Xingmu Liu, Jurong Yang
Better early detection methods are needed to improve the outcomes of patients with colorectal cancer (CRC). Proton nuclear magnetic resonance spectroscopy (1 H-NMR), a potential non-invasive early tumor detection method, was used to profile urine metabolites from 55 CRC patients and 40 healthy controls (HCs). Pattern recognition through orthogonal partial least squares-discriminant analysis (OPLS-DA) was applied to1 H-NMR processed data. Model specificity was confirmed by comparison with esophageal cancers (EC, n=18)...
December 1, 2017: Oncotarget
https://www.readbyqxmd.com/read/29278766/phase-unwinding-for-dictionary-compression-with-multiple-channel-transmission-in-magnetic-resonance-fingerprinting
#19
Riccardo Lattanzi, Bei Zhang, Florian Knoll, Jakob Assländer, Martijn A Cloos
PURPOSE: Magnetic Resonance Fingerprinting reconstructions can become computationally intractable with multiple transmit channels, if the B1 + phases are included in the dictionary. We describe a general method that allows to omit the transmit phases. We show that this enables straightforward implementation of dictionary compression to further reduce the problem dimensionality. METHODS: We merged the raw data of each RF source into a single k-space dataset, extracted the transceiver phases from the corresponding reconstructed images and used them to unwind the phase in each time frame...
December 24, 2017: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/29258686/bioprofiling-of-salvia-miltiorrhiza-via-planar-chromatography-linked-to-bio-assays-high-resolution-mass-spectrometry-and-nuclear-magnetic-resonance-spectroscopy
#20
Ebrahim Azadniya, Gertrud E Morlock
An affordable bioanalytical workflow supports the collection of data on active ingredients, required for the understanding of health-related food, superfood and traditional medicines. Targeted effect-directed responses of single compounds in a complex sample highlight this powerful bioanalytical hyphenation of planar chromatography with (bio)assays. Among many reports about biological properties of Salvia miltiorrhiza Bunge root (Danshen) and their analytical methods, the highly efficient direct bioautography (DB) workflow has not been considered so far...
January 19, 2018: Journal of Chromatography. A
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