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https://www.readbyqxmd.com/read/28331079/characterization-and-vaccine-potential-of-membrane-vesicles-produced-by-francisella-noatunensis-sup-orientalis-in-an-adult-zebrafish-model
#1
Leidy Lagos, Julia I Tandberg, Urska Repnik, Preben Boysen, Erik Ropstad, Deepa Varkey, Ian T Paulsen, Hanne C Winther-Larsen
Vaccine development against extracellular bacteria has been important for the sustainability of the aquaculture industry. In contrast, infections with intracellular pathogens remain largely an unresolved problem. Francisella noatunensis subspecies orientalis (Fno) are Gram-negative, facultative intracellular bacteria that cause the disease francisellosis in fish. Francisellosis is commonly characterized as a chronic granulomatous disease with high morbidity and can result in high mortality depending on the host...
March 22, 2017: Clinical and Vaccine Immunology: CVI
https://www.readbyqxmd.com/read/28315455/7-8-dihydroxyflavone-facilitates-the-action-exercise-to-restore-plasticity-and-functionality-implications-for-early-brain-trauma-recovery
#2
Gokul Krishna, Rahul Agrawal, Yumei Zhuang, Zhe Ying, Afshin Paydar, Neil G Harris, Luiz Fernando F Royes, Fernando Gomez-Pinilla
Metabolic dysfunction accompanying traumatic brain injury (TBI) severely impairs the ability of injured neurons to comply with functional demands. This limits the success of rehabilitative strategies by compromising brain plasticity and function, and highlights the need for early interventions to promote energy homeostasis. We sought to examine whether the TrkB agonist, 7,8-dihydroxyflavone (7,8-DHF) normalizes brain energy deficits and restablishes more normal patterns of functional connectivity, while enhancing the effects of exercise during post-TBI period...
March 14, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28303450/dr%C3%AE-1-mog-35-55-treatment-reduces-lesion-volumes-and-improves-neurological-deficits-after-traumatic-brain-injury
#3
Liu Yang, Zhijia Liu, Honglei Ren, Lei Zhang, Siman Gao, Li Ren, Zhi Chai, Roberto Meza-Romero, Gil Benedek, Arthur A Vandenbark, Halina Offner, Minshu Li
Traumatic brain injury (TBI) results in severe neurological impairments without effective treatments. Inflammation appears to be an important contributor to key pathogenic events such as secondary brain injury following TBI and therefore serves as a promising target for novel therapies. We have recently demonstrated the ability of a molecular construct comprised of the human leukocyte antigen (HLA)-DRα1 domain linked covalently to mouse (m)MOG-35-55 peptide (DRα1-MOG-35-55 construct) to reduce CNS inflammation and tissue injury in animal models of multiple sclerosis and ischemic stroke...
March 16, 2017: Metabolic Brain Disease
https://www.readbyqxmd.com/read/28289563/persistent-erectile-dysfunction-in-men-exposed-to-the-5%C3%AE-reductase-inhibitors-finasteride-or-dutasteride
#4
Tina Kiguradze, William H Temps, Paul R Yarnold, John Cashy, Robert E Brannigan, Beatrice Nardone, Giuseppe Micali, Dennis Paul West, Steven M Belknap
IMPORTANCE: Case reports describe persistent erectile dysfunction (PED) associated with exposure to 5α-reductase inhibitors (5α-RIs). Clinical trial reports and the manufacturers' full prescribing information (FPI) for finasteride and dutasteride state that risk of sexual adverse effects is not increased by longer duration of 5α-RI exposure and that sexual adverse effects of 5α-RIs resolve in men who discontinue exposure. OBJECTIVE: Our chief objective was to assess whether longer duration of 5α-RI exposure increases risk of PED, independent of age and other known risk factors...
2017: PeerJ
https://www.readbyqxmd.com/read/28284784/trends-in-provider-management-of-patients-with-food-protein-induced-enterocolitis-syndrome
#5
Matthew Greenhawt, J Andrew Bird, Anna H Nowak-Węgrzyn
BACKGROUND: Food protein-induced enterocolitis syndrome (FPIES) is a non-IgE-mediated food allergy. OBJECTIVE: To better understand provider-level variation in FPIES knowledge and management. METHODS: A 23-question online survey was administered to AAAAI members during the spring and summer of 2014. RESULTS: Among 470 respondents, 64% reported "full understanding" of FPIES diagnosis/management; 78.8% reported managing 1 or more patient with FPIES; and 80...
March 8, 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/28282960/a-micro-bubble-structure-based-fabry-perot-optical-fiber-strain-sensor-with-high-sensitivity-and-low-cost-characteristics
#6
Lu Yan, Zhiguo Gui, Guanjun Wang, Yongquan An, Jinyu Gu, Meiqin Zhang, Xinglin Liu, Zhibin Wang, Gao Wang, Pinggang Jia
A high-sensitivity, low-cost, ultrathin, hollow fiber micro bubble structure was proposed; such a bubble can be used to develop a high-sensitivity strain sensor based on a Fabry-Perot interferometer (FPI). The micro bubble is fabricated at the fiber tip by splicing a glass tube to a single mode fiber (SMF) and then the glass tube is filled with gas in order to expand and form a micro bubble. The sensitivity of the strain sensor with a cavity length of about 155 μm and a bubble wall thickness of about 6 μm was measured to be up to 8...
March 9, 2017: Sensors
https://www.readbyqxmd.com/read/28271402/cortical-bilateral-adaptations-in-rats-submitted-to-focal-cerebral-ischemia-emphasis-on-glial-metabolism
#7
Yasmine Nonose, Pedro E Gewehr, Roberto F Almeida, Jussemara S da Silva, Bruna Bellaver, Leo A M Martins, Eduardo R Zimmer, Samuel Greggio, Gianina T Venturin, Jaderson C Da Costa, André Quincozes-Santos, Luc Pellerin, Diogo O de Souza, Adriano M de Assis
This study was performed to evaluate the bilateral effects of focal permanent ischemia (FPI) on glial metabolism in the cerebral cortex. Two and 9 days after FPI induction, we analyze [(18)F]FDG metabolism by micro-PET, astrocyte morphology and reactivity by immunohistochemistry, cytokines and trophic factors by ELISA, glutamate transporters by RT-PCR, monocarboxylate transporters (MCTs) by western blot, and substrate uptake and oxidation by ex vivo slices model. The FPI was induced surgically by thermocoagulation of the blood in the pial vessels of the motor and sensorimotor cortices in adult (90 days old) male Wistar rats...
March 7, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28257641/the-effect-of-fertility-stress-on-endometrial-and-subendometrial-blood-flow-among-infertile-women
#8
Yuezhi Dong, Yanna Cai, Yu Zhang, Yurong Xing, Yingpu Sun
BACKGROUND: To investigate the effect of fertility stress on endometrial and subendometrial blood flow among infertile women. METHODS: This case-control study was conducted in The First Affiliated Hospital of Zhengzhou University. The fertility problem inventory (FPI) was adopted to evaluate fertility stress. Three-dimensional power Doppler ultrasonography (3D PD-US) was performed during the proliferative phase of the menstrual cycle (days 5-11) to measure endometrial thickness, pattern, endometrial and subendometrial volume (V), the vascularization index (VI), the flow index (FI) and the vascularization-FI (VFI) index...
March 4, 2017: Reproductive Biology and Endocrinology: RB&E
https://www.readbyqxmd.com/read/28254007/ft-ir-and-raman-spectroscopies-determine-structural-changes-of-tilapia-fish-protein-isolate-and-surimi-under-different-comminution-conditions
#9
Yuka Kobayashi, Steven G Mayer, Jae W Park
Tilapia proteins refined by pH shift and water washing were chopped under various comminution conditions and their structural changes were investigated using Fourier transform infrared (FT-IR) and Raman spectroscopies. Both techniques revealed the degree of unfolding in protein structure increased when fish protein isolate (FPI) and surimi were chopped at 25°C for 18min compared to samples chopped at 5°C for 6min. Results indicated both hydrophobic interactions and disulfide bonds were significantly enhanced during gelation...
July 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28218658/uw-imaging-of-seismic-physical-models-in-air-using-fiber-optic-fabry-perot-interferometer
#10
Qiangzhou Rong, Yongxin Hao, Ruixiang Zhou, Xunli Yin, Zhihua Shao, Lei Liang, Xueguang Qiao
A fiber-optic Fabry-Perot interferometer (FPI) has been proposed and demonstrated for the ultrasound wave (UW) imaging of seismic-physical models. The sensor probe comprises a single mode fiber (SMF) that is inserted into a ceramic tube terminated by an ultra-thin gold film. The probe performs with an excellent UW sensitivity thanks to the nanolayer gold film, and thus is capable of detecting a weak UW in air medium. Furthermore, the compact sensor is a symmetrical structure so that it presents a good directionality in the UW detection...
February 17, 2017: Sensors
https://www.readbyqxmd.com/read/28211341/food-protein-induced-enterocolitis-syndrome
#11
REVIEW
A Nowak-Węgrzyn, E Jarocka-Cyrta, Apb Moschione Castro
Food protein-induced enterocolitis syndrome (FPIES) is a non-IgE-, cell-mediated food allergy of unknown prevalence and pathophysiology. Onset is typically during the first year of life; seafood-induced FPIES may start in adulthood. Acute FPIES manifests within 1-4 hours after ingestion with repetitive emesis, pallor, and lethargy progressing to dehydration and hypovolemic shock in 15% of cases. Chronic FPIES manifests with intermittent emesis, watery diarrhea, and poor growth progressing to dehydration and hypovolemic shock over a period of days to weeks...
2017: Journal of Investigational Allergology & Clinical Immunology
https://www.readbyqxmd.com/read/28192147/systemic-innate-immune-activation-in-food-protein-induced-enterocolitis-syndrome
#12
Ritobrata Goswami, Ana Belen Blazquez, Roman Kosoy, Adeeb Rahman, Anna Nowak-Węgrzyn, M Cecilia Berin
BACKGROUND: Food protein-induced enterocolitis syndrome (FPIES) is a non-IgE-mediated food allergy of infancy whose pathophysiology is poorly understood. OBJECTIVES: We set out to identify and phenotype allergen-responsive cells in peripheral blood of a cohort of subjects undergoing supervised food challenge for FPIES. METHODS: We profiled antigen-responsive cells in PBMCs by flow cytometry, and examined cells in whole blood obtained before and after challenge by CyTOF mass cytometry and RNAseq...
February 10, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28157992/generalized-high-spectral-resolution-lidar-technique-with-a-multimode-laser-for-aerosol-remote-sensing
#13
Zhongtao Cheng, Dong Liu, Yupeng Zhang, Chong Liu, Jian Bai, Dan Wang, Nanchao Wang, Yudi Zhou, Jing Luo, Yongying Yang, Yibing Shen, Lin Su, Liming Yang
High-spectral-resolution lidar (HSRL) is a powerful tool for atmospheric aerosol remote sensing. The current HSRL technique often requires a single longitudinal mode laser as the transmitter to accomplish the spectral discrimination of the aerosol and molecular scattering conveniently. However, single-mode laser is cumbersome and has very strict requirements for ambient stability, making the HSRL instrument not so robust in many cases. In this paper, a new HSRL concept, called generalized HSRL technique with a multimode laser (MML-gHSRL), is proposed, which can work using a multimode laser...
January 23, 2017: Optics Express
https://www.readbyqxmd.com/read/28157119/reduce-beam-hardening-artifacts-of%C3%A2-polychromatic-x-ray-computed-tomography-by-an-iterative-approximation-approach
#14
Hongli Shi, Zhi Yang, Shuqian Luo
BACKGROUND: The beam hardening artifact is one of most important modalities of metal artifact for polychromatic X-ray computed tomography (CT), which can impair the image quality seriously. OBJECTIVE: An iterative approach is proposed to reduce beam hardening artifact caused by metallic components in polychromatic X-ray CT. METHODS: According to Lambert-Beer law, the (detected) projections can be expressed as monotonic nonlinear functions of element geometry projections, which are the theoretical projections produced only by the pixel intensities (image grayscale) of certain element (component)...
February 3, 2017: Journal of X-ray Science and Technology
https://www.readbyqxmd.com/read/28152648/changes-in-apparent-fibre-density-and-track-weighted-imaging-metrics-in-white-matter-following-experimental-traumatic-brain-injury
#15
David Wright, Leigh Johnston, Jeff Kershaw, Roger Ordidge, Terence John O'Brien, Sandy Richard Shultz
Traumatic brain injury (TBI) has been assessed with diffusion tensor imaging (DTI), a commonly used magnetic resonance imaging (MRI) marker for white matter integrity. However, as the DTI model only fits a single fibre orientation, results can become confounded in regions of 'crossing' white matter fibres. In contrast, constrained spherical deconvolution estimates a fibre orientation distribution directly from high angular resolution diffusion weighted images. Consequently, constrained spherical deconvolution-based measures such as apparent fibre density and track-weighted imaging metrics (including tract density imaging, average pathlength mapping, and mean curvature), may be more sensitive than DTI metrics to white matter injury following TBI...
February 3, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/28149661/biomechanical-podiatric-evaluation-in-an-italian-cohort-of-patients-with-systemic-sclerosis-a-pilot-study
#16
Susanna Maddali Bongi, Giovanni Ravenni, Benedetta Ciampi, Angela Del Rosso, Khadija El Aoufy
OBJECTIVE: Foot problems are often present in Systemic Sclerosis (SSc) patients, however studies regarding podiatric problems related to SSc are lacking and there are no data evaluating the foot biomechanical changes. The aim of the present pilot study was to evaluate podiatric problems in an Italian cohort of SSc patients by assessing received podiatric services, foot pain and disability and biomechanical foot deformity. MATERIAL AND METHODS: 25 consecutive SSc patients were enrolled from the Division of Rheumatology, University of Florence...
December 2016: European Journal of Rheumatology
https://www.readbyqxmd.com/read/28134855/low-coherence-interferometric-fiber-optic-sensors-with-potential-applications-as-biosensors
#17
Marzena Hirsch, Daria Majchrowicz, Paweł Wierzba, Matthieu Weber, Mikhael Bechelany, Małgorzata Jędrzejewska-Szczerska
Fiber-optic Fabry-Pérot interferometers (FPI) can be applied as optical sensors, and excellent measurement sensitivity can be obtained by fine-tuning the interferometer design. In this work, we evaluate the ability of selected dielectric thin films to optimize the reflectivity of the Fabry-Pérot cavity. The spectral reflectance and transmittance of dielectric films made of titanium dioxide (TiO₂) and aluminum oxide (Al₂O₃) with thicknesses from 30 to 220 nm have been evaluated numerically and compared...
January 28, 2017: Sensors
https://www.readbyqxmd.com/read/28131968/effect-of-intravenous-plasma-transfusion-on-granulocyte-and-monocyte-oxidative-and-phagocytic-activity-in-dairy-calves-with-failure-of-passive-immunity
#18
Victoria C Yang, Maire C Rayburn, Munashe Chigerwe
Plasma administration has been recommended in calves older than 48h with failure of passive immunity (FPI) to provide immunity consistent with adequate colostral ingestion. However, the protective serum immunoglobulin G (IgG) concentrations (≥1000mg/dL) of plasma derived IgG only lasts up to 12h. In addition to IgG, maternally derived colostral cells also confer immunity. The objective of the study was to determine the effect of intravenous plasma transfusion on granulocyte and monocyte oxidative and phagocytic activity in calves with FPI...
January 21, 2017: Research in Veterinary Science
https://www.readbyqxmd.com/read/28120606/a-very-unusual-case-of-food-allergy-between-fpies-and-ige-mediated-food-allergy
#19
S Miceli Sopo, S Monaco, G Cerchiara, G Bersani
Food protein induced enterocolitis syndrome (FPIES) is a food-related gastrointestinal hypersensitivity disorder, probably non-IgE-mediated. Over the years, various diagnostic criteria have been proposed to identify FPIES. In the last few years, there was an increased interest from researchers about FPIES's syndrome, that frequently brought to discover new aspects of this disease. We describe an unusual case of FPIES to egg in a 21-months-old child, because of its clinical characteristics that reflect some aspects of IgE-mediated allergy and other of non IgE-mediated allergy...
January 2017: European Annals of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28117255/examination-of-the-correlation-between-foot-morphology-measurements-using-pedography-and-radiographic-measurements
#20
Kentaro Inui, Kazuya Ikoma, Kan Imai, Suzuyo Ohashi, Masahiro Maki, Masamitsu Kido, Yusuke Hara, Yoshinobu Oka, Hiroyoshi Fujiwara, Toshikazu Kubo
Pedography provides excellent visualization of the footprint. However, the correlation between the footprint images and radiographic measures has not been thoroughly evaluated. Therefore, the objectives of our study were to examine the correlation between the pedography-based measures of foot morphology and radiographic measurements and to propose reference values for the diagnosis of flatfoot using footprint imaging. The plantar footprints of 100 right feet were photographed using a pedography standing platform...
March 2017: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
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