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Marilia de Almeida Correia, Aluísio Andrade-Lima, Paulo Longano Mesquita de Oliveira, Rômulo Martins Domiciano, Wagner Jorge Ribeiro Domingues, Nelson Wolosker, Pedro Puench-Leão, Raphael Mendes Ritti-Dias, Gabriel Grizzo Cucato
BACKGROUND: The vascular quality of life questionnaire (VascuQoL-6) was proposed to evaluate specific quality of life in peripheral arterial disease patients (PAD). However, there is no Brazilian-Portuguese version available, blunting its use in Brazilian patients. OBJECTIVE: To analyze the psychometric properties of a translated Brazilian-Portuguese version of VascuQoL-6 in Brazilian patients with PAD with intermittent claudication symptoms. METHODS: One hundred and eleven patients with PAD participated in the study...
May 14, 2018: Annals of Vascular Surgery
Luzia Aparecida Costa Barreira, Priscila Santos Scheucher, Marilia Farignoli Romeiro, Leonardo La Serra, Soraya Jabur Badra, William Marciel de Souza, Luiz Tadeu Moraes Figueiredo
INTRODUCTION: Dengue virus (DENV) is the most important arthropod-borne viral disease worldwide with an estimated 50 million infections occurring each year. METHODS: In this study, we present a flow cytometry assay (FACS) for diagnosing DENV, and compare its results with those of the non-structural protein 1 (NS1) immunochromatographic assay and reverse transcriptase polymerase chain reaction (RT-PCR). RESULTS: All three assays identified 29...
March 2018: Revista da Sociedade Brasileira de Medicina Tropical
Ivam Freire da Silva-Júnior, Andréia Drawanz Hartwig, Giulia Tarquinio Demarco, Vanessa Müller Stüermer, Gisele Scobernatti, Marília Leão Goettems, Marina Sousa Azevedo
PURPOSE: This study's aim was to evaluate the health-related quality of life (HRQoL) and associated factors of maltreated children and adolescents. METHODS: This cross-sectional study consisted of individuals between 8 and 17 years of age who were victims of maltreatment. The KIDSCREEN-52 was used to measure their HRQoL. Socioeconomic and demographic data were collected, as well as information about the type of abuse, type of perpetrator, and psychological support adherence...
May 15, 2018: Quality of Life Research
Denis Bernardi Bichuetti, Marília Mamprim de Moraes Perin, Nilton Amorim de Souza, Enedina Maria Lobato de Oliveira
BACKGROUND: Neuromyelitis optica leads to severe disability. Preventive treatment includes steroids and immunosuppressants, and indications are based on retrospective and observational studies. METHODS: We analyzed 158 patients with neuromyelitis optica regarding disease course, prognostic factors, and treatment response to azathioprine, a widely available low-cost drug. Disability accumulation was used as an endpoint to treatment response. RESULTS: Eight patients with monophasic and 150 with relapsing disease with a median 7 years of disease duration and 4...
May 1, 2018: Multiple Sclerosis: Clinical and Laboratory Research
Priscille de Dumast, Clément Mirabel, Lucia Cevidanes, Antonio Ruellas, Marilia Yatabe, Marcos Ioshida, Nina Tubau Ribera, Loic Michoud, Liliane Gomes, Chao Huang, Hongtu Zhu, Luciana Muniz, Brandon Shoukri, Beatriz Paniagua, Martin Styner, Steve Pieper, Francois Budin, Jean-Baptiste Vimort, Laura Pascal, Juan Carlos Prieto
OBJECTIVE: The purpose of this study is to describe the methodological innovations of a web-based system for storage, integration and computation of biomedical data, using a training imaging dataset to remotely compute a deep neural network classifier of temporomandibular joint osteoarthritis (TMJOA). METHODS: This study imaging dataset consisted of three-dimensional (3D) surface meshes of mandibular condyles constructed from cone beam computed tomography (CBCT) scans...
May 1, 2018: Computerized Medical Imaging and Graphics: the Official Journal of the Computerized Medical Imaging Society
Diego P Rubert, Edna A Hoshino, Marília D V Braga, Jens Stoye, Fábio V Martinez
BACKGROUND: The genomic similarity is a large-scale measure for comparing two given genomes. In this work we study the (NP-hard) problem of computing the genomic similarity under the DCJ model in a setting that does not assume that the genes of the compared genomes are grouped into gene families. This problem is called family-free DCJ similarity. RESULTS: We propose an exact ILP algorithm to solve the family-free DCJ similarity problem, then we show its APX-hardness and present four combinatorial heuristics with computational experiments comparing their results to the ILP...
May 8, 2018: BMC Bioinformatics
Marília Silveira de Almeida Campos, Lorena Rocha Ayres, Manuela Roque Siane Morelo, Fabiana Angelo Marques Carizio, Leonardo Régis Leira Pereira
Background Valproate is a widely prescribed antiepileptic drug for generalized epilepsies, due to the extensive knowledge on its efficacy since it is on the market for many decades. However, a large number of new antiepileptic medicines was introduced into clinical practice and may be better options for treatment, considering that these medicines differ in terms of efficacy spectrum. Despite extensive research, questions regarding which medicine would constitute the first option for the monotherapy treatment of generalized epilepsy remain...
May 9, 2018: International Journal of Clinical Pharmacy
Carlos Bistafa, Yukichi Kitamura, Marilia T C Martins-Costa, Masataka Nagaoka, Manuel F Ruiz-Lopez
We describe a method to locate stationary points in the free-energy hypersurface of complex molecular systems using high-level correlated ab initio potentials. In this work, we assume a combined QM/MM description of the system although generalization to full ab initio potentials or other theoretical schemes is straightforward. The free-energy gradient (FEG) is obtained as the mean force acting on relevant nuclei using a dual level strategy. First, a statistical simulation is carried out using an appropriate, low-level quantum mechanical force-field...
May 9, 2018: Journal of Chemical Theory and Computation
Gabriela Nagata, Thalita Santana, Aline Queiroz, Renata Helena Caramez, Marília Trierveiler
BACKGROUND: We analyzed the different grades of dysplasia in the epithelium adjacent to lip squamous cell carcinoma (LSCC), as a parallel to actinic cheilitis (AC) that suffered malignant transformation. METHODS: Forty samples of epithelium adjacent to LSCC were histologically graded according to the World Health Organization (WHO) and the binary systems. The expression of mutated p53 was evaluated through immunohistochemistry. RESULTS: According to WHO system, 37...
May 8, 2018: Journal of Cutaneous Pathology
Natália Mello Santos, Maísa Camillo Jordão, Franciny Querobim Ionta, Fernanda Lyrio Mendonça, Camilla Cristina Lira Di Leone, Marília Afonso Rabelo Buzalaf, Thais Marchini Oliveira, Heitor Marques Honório, Thiago Cruvinel, Daniela Rios
This study investigated the effect of the period of use and location of intraoral appliances on enamel surface loss. This randomized, single blind in situ study was conducted in 2 crossover phases based on the period of use, in which maxillary and mandibular appliances were simultaneously worn. Bovine enamel blocks (n = 120) were randomly divided among the studied groups by surface hardness. In each phase, fifteen volunteers used one maxillary appliance and two mandibular appliances for 5 days. Erosive challenge was performed 4X/day by immersion in 0...
2018: PloS One
Argentina Muianga, Gabriela Pinto, Marilia Massangaie, Sadia Ali, John Oludele, Almiro Tivane, Kerstin I Falk, Nina Lagerqvist, Eduardo S Gudo
An outbreak of dengue and high densities of Aedes aegypti were reported in 2014 in northern Mozambique, suggesting an increased risk for other arboviruses such as chikungunya virus (CHIKV) in this region. The aim of this study was to investigate the occurrence of CHIKV during an outbreak of dengue virus (DENV) in Pemba city in northern Mozambique in 2014. Febrile patients (n = 146) seeking medical attention at the Pemba Provincial Hospital between March and April 2014 were enrolled in this study. Blood samples from each participant were tested for chikungunya and DENV RNA, IgM and IgG antibodies using PCR and ELISA, respectively...
May 7, 2018: Vector Borne and Zoonotic Diseases
Guilhermo F S Congio, Camila D A Batalha, Marília B Chiavegato, Alexandre Berndt, Patrícia P A Oliveira, Rosa T S Frighetto, Thomas M R Maxwell, Pablo Gregorini, Sila C Da Silva
Agricultural systems are responsible for environmental impacts that can be mitigated through the adoption of more sustainable principles. Our objective was to investigate the influence of two pre-grazing targets (95% and maximum canopy light interception during pasture regrowth; LI95% and LIMax , respectively) on sward structure and herbage nutritive value of elephant grass cv. Cameroon, and dry matter intake (DMI), milk yield, stocking rate, enteric methane (CH4 ) emissions by Holstein × Jersey dairy cows...
May 1, 2018: Science of the Total Environment
Helena Maciel-Guerra, Mariana Álvares Penha, Marília Formentini Scotton Jorge, Ricardo da Silva Libório, Ana Cláudia Nazareno Dos Anjos Carrijo, Maria Rita Parise-Fortes, Hélio Amante Miot
BACKGROUND: Several dermatoses are mediated by histamine, such as urticaria, angioedema, and papular urticaria. There are no Brazilian studies comparing the potency of antihistamines. OBJECTIVES: To evaluate the tolerability and efficacy of the main commercial brand and generic H1 antihistamines, regarding the suppression of the wheal and flare to the histamine test. METHODS: A quasi-experimental, open study with 10 healthy adults submitted to the histamine test on the ventral aspect of the forearms...
March 2018: Anais Brasileiros de Dermatologia
Marília Miranda da Conceição Araújo, Mara Rodrigues Martins, Anna Rachel Dos Santos Soares, Luísa Rodrigues de Abreu Carvalho, Viviane Elisângela Gomes, Efigênia Ferreira E Ferreira, Luís Otávio Miranda Cota, Maria Inês Barreiros Senna, Raquel Conceição Ferreira
AIMS: To evaluate the effects of complete denture (CD) quality and user satisfaction on the use of CDs provided by primary care services at 1 and 5 years postinsertion. MATERIALS AND METHODS: A random sample of 233 individuals were evaluated regarding the use of maxillary and/or mandibular CDs at 1 and 5 years after insertion; at both time points, denture quality, integrity, and user satisfaction were measured. The covariates included age, gender, marital status, years of education, family income, past use of CD, time since maxillary teeth loss, mandibular ridge height, and frequency of return visits to the dentist after receiving the prostheses...
May 2018: International Journal of Prosthodontics
Sheile Pinheiro de Jesus, Ana Carla Marques da Costa, Regina Bones Barcellos, Rubia Marília de Medeiros, Cláudia Maria Dornelles da Silva, Maria Lucia Rossetti
HPV types 16 and 18 were studied in paraffin-fixed cervical biopsy collected in southern Brazil. HPV 16, HPV 18 and co-infection HPV 16/18 were identified in 10/57 (17.5%), 4/57 (7%) and in 43/57 (75.4%) samples, respectively. Southern Brazil has one of the highest prevalence rates of HPV 16/18 reported.
April 24, 2018: Brazilian Journal of Microbiology: [publication of the Brazilian Society for Microbiology]
Flávia Sayuri Matsuo, Marília Ferreira Andrade, Adriano Mota Loyola, Sindeval José da Silva, Marcelo José Barbosa Silva, Sérgio Vitorino Cardoso, Paulo Rogério de Faria
Phosphatidylinositol-3-kinases are kinases that lead to AKT phosphorylation and thus mTOR and GSK3β activation. These proteins are linked to tumorigenesis, but their roles in driving cervical lymph node (CLN) metastasis of oral squamous cell carcinoma (OSCC) cells are unknown. This study aimed to investigate the role of AKT, mTOR, and GSK3β proteins in the occurrence of CLN metastasis in OSCC patients. Ninety and 18 paraffin-embedded OSCC and oral mucosa samples were included, respectively. We divided our OSCC patients into non-metastasizing (PNM) and metastasizing (PM) groups, and the expression of total AKT, pAKT1Thr308 , pAKTSer473 , GSK3β, pGSK3βSer9 , and pmTORSer2448 was analyzed by immunohistochemistry...
April 30, 2018: Virchows Archiv: An International Journal of Pathology
Zohaib Nisar Khan, Isabela Tomazini Sabino, Carina Guimarães de Souza Melo, Tatiana Martini, Heloísa Aparecida Barbosa da Silva Pereira, Marília Afonso Rabelo Buzalaf
Appropriate doses of fluoride (F) have therapeutic action against dental caries, but higher levels can cause disturbances in soft and mineralized tissues. Interestingly, the susceptibility to the toxic effects of F is genetically determined. This study evaluated the effects of F on the liver proteome of mice susceptible (A/J) or resistant (129P3/J) to the effects of F. Weanling male A/J (n = 12) and 129P3/J (n = 12) mice were housed in pairs and assigned to two groups given low-F food and drinking water containing 15 or 50 ppm F for 6 weeks...
April 29, 2018: Biological Trace Element Research
Valentina Satta, Maria Elena Manca, Laura Torres-Rovira, Sara Succu, Paolo Mereu, Michella Nehme, Gianpaolo Epifani, Marilia Gallus, Fiammetta Berlinguer, Salvatore Naitana, Giovanni Giuseppe Leoni
The purpose of this study was to investigate the effects of ram melatonin treatment on the sperm quality and metabolite composition of the seminal plasma in the non-breeding season. Four mature rams were treated with 54 mg melatonin in March subcutaneous implants and four untreated rams served as control. At 0, 30, 90 and 120 days semen samples were collected and sperm, separated from seminal plasma, was evaluated for its capacity to fertilize and produce embryos in vitro. Seminal plasma metabolites were extracted and analyzed by capillary electrophoresis/mass spectroscopy...
April 23, 2018: Theriogenology
Marília C M Ribeiro, Camila C Amorim, Regina F P M Moreira, Luiz C A Oliveira, Andréia B Henriques, Mônica M D Leão
Semiconductors based on Fe/Nb oxides can present both solar sensitivity and high catalytic activity. However, there is still a lack regarding the comparison between different routes to produce Fe/Nb-based solar photocatalysts and the evaluation of the impact of the synthesis operating conditions on the material properties. In this work, Fe/Nb2 O5 ratio, type of precipitating agent, presence/absence of washing stage, and temperature of calcination were verified to be the most relevant parameters in the synthesis by the co-precipitation method...
April 27, 2018: Environmental Science and Pollution Research International
Marilia Ladeira de Araújo, Wellington Duarte, Augusto César Penalva de Oliveira, Maria Rita Polo Gascón, Luiz Augusto Marcondes Fonseca, Raquel de Melo Alves Paiva, Bárbara Santana, Rodrigo Tocantins Calado, Jorge Casseb
OBJECTIVE: We evaluated the association between cognitive deficits and leukocyte telomere length (LTL) in HIV-1-infected individuals. DESIGN: 73 HIV-1-infected patients undergoing neuropsychological evaluation and 91 healthy controls were included in this study. Fifteen HIV-1 positive patients did not have cognitive disorders whereas 26 had asymptomatic neurocognitive disorder (ANI), 13 presented mild to moderate neurocognitive disorder (MND), and 10 had HIV-associated dementia (HAD)...
2018: Revista do Instituto de Medicina Tropical de São Paulo
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