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https://www.readbyqxmd.com/read/28912017/indoleamine-2-3-dioxygenase-1-increased-in-human-gastric-pre-neoplasia-promotes-inflammation-and-metaplasia-in-mice-and-is-associated-with-type-ii-hypersensitivity-autoimmunity
#1
Mohamad El-Zaatari, Adam J Bass, Reanne Bowlby, Min Zhang, Li-Jyun Syu, Yitian Yang, Helmut Grasberger, Andrew Shreiner, Bei Tan, Shrinivas Bishu, Wai K Leung, Andrea Todisco, Nobuhiko Kamada, Marilia Cascalho, Andrzej A Dlugosz, John Y Kao
BACKGROUND & AIMS: Chronic gastrointestinal inflammation increases the risk of cancer by mechanisms that are not well understood. Indoleamine-2,3-dioxygenase 1 (IDO1) is a heme-binding enzyme that regulates the immune response via catabolization and regulation of tryptophan availability for immune cell uptake. IDO1 expression is increased during the transition from chronic inflammation to gastric metaplasia. We investigated whether IDO1 contributes to the inflammatory response that mediates loss of parietal cells leading to metaplasia...
September 11, 2017: Gastroenterology
https://www.readbyqxmd.com/read/28902861/epigenetic-regulation-of-metalloproteinases-and-their-inhibitors-in-rotator-cuff-tears
#2
Mariana Ferreira Leal, Leonardo Caires Dos Santos, Adrielle Martins de Oliveira, Paulo Santoro Belangero, Eduardo Antônio Figueiredo, Carina Cohen, Felipe de Seixas Alves, Wânia Hiromi Yanaguizawa, Carlos Vicente Andreoli, Alberto de Castro Pochini, Benno Ejnisman, Marília Cardoso Smith, Maria Teresa de Seixas Alves, Moises Cohen
Rotator cuff tear is a common orthopedic condition. Metalloproteinases (MMP) and their inhibitors (TIMP) seem to play a role in the development of joint injuries and in the failure of tissue healing. However, the mechanisms of regulation of gene expression in tendons are still unknown. Epigenetic mechanisms, such as DNA methylation and microRNAs regulation, are involved in the dynamic control of gene expression. Here, the mRNA expression and DNA methylation status of MMPs (MMP1, MMP2, MMP3, MMP9, MMP13, and MMP14) and TIMPs (TIMP1-3) and the expression of miR-29 family members in ruptured supraspinatus tendons were compared with non-injured tendons of individuals without this lesion...
2017: PloS One
https://www.readbyqxmd.com/read/28902322/evaluation-of-body-posture-in-nursing-students
#3
Marília Fernandes Andrade, Érika de Cássia Lopes Chaves, Michele Rita Oliveira Miguel, Talita Prado Simão, Denismar Alves Nogueira, Denise Hollanda Iunes
OBJECTIVE: To investigate the body posture of nursing students before and after clinical practice. METHOD: The study was developed in two stages. Initially the body posture of students of the 2nd, 4th, 6th, and 8th periods were assessed through photogrammetry. All images were analyzed in a random and masked manner with CorporisPro® 3.1.3 software. Three evaluations were performed for each angle and then the mean value was calculated. Two years later, when the 4th period students had developed their clinical internships, their body posture was again evaluated...
August 28, 2017: Revista da Escola de Enfermagem da U S P
https://www.readbyqxmd.com/read/28901658/monoclonal-antibodies-production-platforms-an-opportunity-study-of-a-non-protein-a-chromatographic-platform-based-on-process-economics
#4
António Lima Grilo, Marilia Mateus, M Raquel Aires-Barros, Ana M Azevedo
Monoclonal antibodies currently dominate the biopharmaceutical market with growing sales having reached 80 billion USD in 2016. As most top-selling mAbs are approaching the end of their patent life, biopharmaceutical companies compete fiercely in the biosimilars market. These two factors present a strong motivation for alternative process strategies and process optimization. In this work a novel purification strategy for monoclonal antibodies comprising phenylboronic acid multimodal chromatography for capture followed by polishing by ion exchange monolithic chromatography and packed bed hydrophobic interaction chromatography is presented and compared to the traditional protein-A-based process...
September 13, 2017: Biotechnology Journal
https://www.readbyqxmd.com/read/28895751/extreme-skeletal-open-bite-correction-with-vertical-elastics
#5
Marco Antonio Cruz-Escalante, Aron Aliaga-Del Castillo, Luciano Soldevilla, Guilherme Janson, Marilia Yatabe, Ricardo Voss Zuazola
Severe skeletal open bites may be ideally treated with a combined surgical-orthodontic approach. Alternatively, compensations may be planned to camouflage the malocclusion with orthodontics alone. This case report describes the treatment of an 18-year-old man who presented with a severe open bite involving the anterior and posterior teeth up to the first molars, increased vertical dimension, bilateral Class III molar relationship, bilateral posterior crossbite, dental midline deviation, and absence of the maxillary right canine and the mandibular left first premolar...
September 12, 2017: Angle Orthodontist
https://www.readbyqxmd.com/read/28877281/effect-of-vegetable-oils-applied-over-acquired-enamel-pellicle-on-initial-erosion
#6
Franciny Querobim Ionta, Catarina Ribeiro Barros de Alencar, Poliana Pacifico Val, Ana Paula Boteon, Maisa Camillo Jordão, Heitor Marques Honório, Marília Afonso Rabelo Buzalaf, Daniela Rios
Objective: The prevalence of dental erosion has been recently increasing, requiring new preventive and therapeutic approaches. Vegetable oils have been studied in preventive dentistry because they come from a natural, edible, low-cost, and worldwide accessible source. This study aimed to evaluate the protective effect of different vegetable oils, applied in two concentrations, on initial enamel erosion. Material and Methods: Initially, the acquired pellicle was formed in situ for 2 hours...
July 2017: Journal of Applied Oral Science: Revista FOB
https://www.readbyqxmd.com/read/28877278/effect-of-photodynamic-therapy-and-non-thermal-plasma-on-root-canal-filling-analysis-of-adhesion-and-sealer-penetration
#7
Marilia Menezes, Maíra Prado, Brenda Gomes, Heloisa Gusman, Renata Simão
Objective: The aim of this study was to evaluate the effect of photodynamic therapy (PDT) and non-thermal plasma (NTP) on adhesion and sealer penetration in root canals. Material and Methods: Sixty single-rooted premolars were used. The teeth were prepared using a crown-down technique. NaOCl and EDTA were used for irrigation and smear layer removal, respectively. The root canals were divided into three groups: control, PDT, and NTP. After treatments, the roots were filled using gutta-percha and either AH Plus (AHP) or MTA Fillapex (MTAF) sealers...
July 2017: Journal of Applied Oral Science: Revista FOB
https://www.readbyqxmd.com/read/28876381/assessment-of-the-antiproliferative-and-antigenotoxic-activity-and-phytochemical-screening-of-aqueous-extracts-of-sambucus-australis-cham-schltdl-adoxaceae
#8
Marília Tedesco, Andrielle W Kuhn, Viviane Dal-Souto Frescura, Aline A Boligon, Margareth L Athayde, Solange B Tedesco, Antonio C F DA Silva
The purpose of this study was to evaluate the antiproliferative and antigenotoxic activity of Sambucus australis Cham. & Schltdl. aqueous extracts on the cell cycle of Allium cepa L. as well as determine the phenolic compounds in such extracts. S. australis inflorescences and leaves of two accessions were used for aqueous extract preparation at concentrations: 0.003 g/ml and 0.012 g/ml. A. cepa bulbs were rooted in distilled water and, subsequently, placed in treatments for 24 hours. Rootlets were collected and fixed in modified Carnoy's solution for 24 hours and kept...
August 31, 2017: Anais da Academia Brasileira de Ciências
https://www.readbyqxmd.com/read/28875505/atlantic-bats-a-dataset-of-bat-communities-from-the-atlantic-forests-of-south-america
#9
Renata de Lara Muylaert, Richard D Stevens, Carlos Eduardo Lustosa Esbérard, Marco Aurelio Ribeiro Mello, Guilherme Siniciato Terra Garbino, Luiz H Varzinczak, Deborah Faria, Marcelo de Moraes Weber, Patricia Kerches Rogeri, André Luis Regolin, Hernani Fernandes Magalhães de Oliveira, Luciana de Moraes Costa, Marília A S Barros, Gilberto Sabino-Santos, Mara Ariane Crepaldi de Morais, Vinicius Silva Kavagutti, Fernando C Passos, Emma-Liina Marjakangas, Felipe Gonçalves Motta Maia, Milton Cezar Ribeiro, Mauro Galetti
Bats are the second most diverse mammal order and they provide vital ecosystem functions (e.g., pollination, seed dispersal, and nutrient flux in caves) and services (e.g., crop pest suppression). Bats are also important vectors of infectious diseases, harboring more than 100 different virus types. In the present study, we compiled information on bat communities from the Atlantic Forests of South America, a species-rich biome that are highly threatened by habitat loss and fragmentation. ATLANTIC BATS dataset comprises 135 quantitative studies carried out in 205 sites, which cover most vegetation types of the tropical and subtropical Atlantic Forest: dense ombrophilous forest, mixed ombrophilous forest, semideciduous forest, deciduous forest, savanna, steppe, and open ombrophilous forest...
September 6, 2017: Ecology
https://www.readbyqxmd.com/read/28868482/self-expandable-metal-stents-for-colorectal-cancer-from-guidelines-to-clinical-practice
#10
Maria Pia Costa Santos, Carolina Palmela, Rosa Ferreira, Elídio Barjas, António Alberto Santos, Rui Maio, Marília Cravo
INTRODUCTION: Colonic self-expandable metal stent placement is widely used for palliation of obstructive colorectal cancer. The European recommendations for stent placement as a bridge to elective surgery in obstructive colorectal cancer were recently reviewed. The aim of this study was to evaluate the efficacy and safety of stent placement in obstructive colorectal cancer and to discuss these recent guidelines. MATERIALS AND METHODS: Demographic characteristics, procedure indications, complications and final outcome in patients with obstructive colorectal cancer who underwent endoscopic stent placement between January 2012 and June 2015 were retrospectively analyzed...
November 2016: GE Port J Gastroenterol
https://www.readbyqxmd.com/read/28864274/retraction-notice-to-obesity-induced-increase-in-tumor-necrosis-factor-%C3%AE-leads-to-development-of-colon-cancer-in-mice-gastroenterology-2012-143-741-753-e4
#11
Marcelo B S Flores, Guilherme Z Rocha, Danilo M Damas-Souza, Felipe Osório-Costa, Marília M Dias, Eduardo R Ropelle, Juliana A Camargo, Rita B de Carvalho, Hernandes F Carvalho, Mario J A Saad, José B C Carvalheira
This article has been retracted: please see Elsevier Policy on Article Withdrawal (http://www.elsevier.com/locate/withdrawalpolicy). This article has been retracted at the request of the Editor-in-Chief and Deputy Editor-in-Chief following an investigation into the data that were presented in several figures within the article. A number of images used in this article are believed to be duplicated images. The authors stated that they inadvertently inserted images of the wrong blots in several of the figures, resulting in the duplications; however, they did not address all of the concerns raised...
September 2017: Gastroenterology
https://www.readbyqxmd.com/read/28863913/bone-anchored-maxillary-protraction-therapy-in-patients-with-unilateral-complete-cleft-lip-and-palate-3-dimensional-assessment-of-maxillary-effects
#12
Marília Yatabe, Daniela Gamba Garib, Renato André de Souza Faco, Hugo de Clerck, Guilherme Janson, Tung Nguyen, Lucia Helena Soares Cevidanes, Antonio Carlos Ruellas
INTRODUCTION: The aim of this study was to 3-dimensionally assess the treatment outcomes of bone-anchored maxillary protraction (BAMP) in patients with unilateral cleft lip and palate. METHODS: The cleft group comprised 24 patients with unilateral cleft lip and palate and Class III malocclusion with mean initial and final ages of 11.8 and 13.2 years, respectively. The noncleft group comprised 24 noncleft patients with Class III malocclusion with mean initial and final ages of 11...
September 2017: American Journal of Orthodontics and Dentofacial Orthopedics
https://www.readbyqxmd.com/read/28862539/lead-pb-exposure-induces-disturbances-in-epigenetic-status-in-workers-exposed-to-this-metal
#13
Paula Pícoli Devóz, Willian Robert Gomes, Marília Ladeira De Araújo, Diego Luis Ribeiro, Tatiana Pedron, Lusânia Maria Greggi Antunes, Bruno Lemos Batista, Fernando Barbosa, Gustavo Rafael Mazzaron Barcelos
Previous studies showed that lead (Pb) exposure may modulate gene expression by changes in the epigenetic status. However, little is known about the impact of Pb exposure and alterations on DNA methylation patterns in humans exposed to this metal. The aim of this study was to assess the consequences of exposure to Pb on DNA global methylation, in order to gain a better understanding of the interactions between Pb exposure and epigenetic effects. The study included 100 male workers employed in automotive battery factories from Paraná State, Brazil...
September 1, 2017: Journal of Toxicology and Environmental Health. Part A
https://www.readbyqxmd.com/read/28856015/antenatal-corticosteroid-treatment-for-the-prevention-of-peri-intraventricular-haemorrhage-in-preterm-newborns-a-retrospective-cohort-study-using-transfontanelle-ultrasonography
#14
Bianca A Almeida, Livia T Rios, Edward Araujo Júnior, Luciano M Nardozza, Antonio F Moron, Marília G Martins
OBJECTIVE: The objective of this study was to assess the correlation between antenatal corticosteroids and peri-intraventricular haemorrhage (PIVH) using transfontanelle ultrasonography, as well as to evaluate the risk factors for its incidence. METHODS: We performed a retrospective cohort study using medical records of preterm newborns. The protocol for maternal corticoid administration for foetal lung maturation included dexamethasone 4 mg (intramuscular) 8/8 hours per 48 hours, with one cycle per week...
June 2017: Journal of Ultrasonography
https://www.readbyqxmd.com/read/28854934/social-vulnerability-and-factors-associated-with-oral-impact-on-daily-performance-among-adolescents
#15
Inara Pereira da Cunha, Antônio Carlos Pereira, Antônio Carlos Frias, Vladen Vieira, Marcelo de Castro Meneghim, Marília Jesus Batista, Karine Laura Cortellazzi, Jaqueline Vilela Bulgareli
BACKGROUND: Oral disorders may negatively affect the quality of life (QoL) of adolescents. To investigate how social vulnerability and oral-health status factors affect QoL in 15-19 years olds who participated in the "SB São Paulo 2015" state survey. METHODS: The relationship of several independent variables, namely Paulista Social Vulnerability Index (PSVI) score, gender, skin color, family income, age, untreated caries, tooth loss [determined by the Decayed, Missing, Filled-Teeth (DMF-T) index], toothache, periodontal condition [determined by the Community Periodontal Index (CPI)], and malocclusion (maxillary overjet, cross bite, or open bite) affect daily life, measured by the Oral Impacts on Daily Performance (OIDP) instrument...
August 30, 2017: Health and Quality of Life Outcomes
https://www.readbyqxmd.com/read/28853537/is-digital-technology-sufficient-to-counteract-sedentary-behavior
#16
Rodrigo L Vancini, Marília S Andrade, Claudio A Barbosa de Lira
No abstract text is available yet for this article.
October 2017: Journal of Sports Medicine and Physical Fitness
https://www.readbyqxmd.com/read/28843883/fatigue-strength-of-yttria-stabilized-zirconia-polycrystals-effects-of-grinding-polishing-glazing-and-heat-treatment
#17
Camila Pauleski Zucuni, Luís Felipe Guilardi, Marilia Pivetta Rippe, Gabriel Kalil Rocha Pereira, Luiz Felipe Valandro
This study aimed to evaluate and compare the effect of different surface post-processing treatments (polishing, heat treatment, glazing, polishing + heat treatment and polishing + glazing) on the superficial characteristics (micromorphology and roughness), phase transformation and fatigue strength of a Y-TZP ceramic ground with diamond bur. Discs of Y-TZP ceramic were manufactured (ISO:6872-2015; final dimensions of 15mm in diameter and 1.2 ± 0.2mm in thickness) and randomly allocated according to the surface condition: Ctrl - as-sintered; Gr - ground with coarse diamond bur; Gr+HT - ground and subjected to the heat treatment; Gr+Pol - ground and polished; Gr+Pol+HT - ground, polished and heat treated; Gr+Gl - ground and glazed; Gr+Pol+Gl - ground, polished and glazed...
June 15, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/28840249/a-kinase-phosphatase-network-that-regulates-kinetochore-microtubule-attachments-and-the-sac
#18
Giulia Vallardi, Marilia Henriques Cordeiro, Adrian Thomas Saurin
The KMN network (for KNL1, MIS12 and NDC80 complexes) is a hub for signalling at the outer kinetochore. It integrates the activities of two kinases (MPS1 and Aurora B) and two phosphatases (PP1 and PP2A-B56) to regulate kinetochore-microtubule attachments and the spindle assembly checkpoint (SAC). We will first discuss each of these enzymes separately, to describe how they are regulated at kinetochores and why this is important for their primary function in controlling either microtubule attachments or the SAC...
2017: Progress in Molecular and Subcellular Biology
https://www.readbyqxmd.com/read/28834075/therapeutic-inertia-in-the-treatment-of-hyperglycaemia-in-patients-with-type-2-diabetes-a-systematic-review
#19
REVIEW
Kamlesh Khunti, Marilia B Gomes, Stuart Pocock, Marina V Shestakova, Stéphane Pintat, Peter Fenici, Niklas Hammar, Jesús Medina
AIMS: Therapeutic inertia, defined as the failure to initiate or intensify therapy in a timely manner according to evidence-based clinical guidelines, is a key reason for uncontrolled hyperglycaemia in patients with type 2 diabetes. The aims of this systematic review were to identify how therapeutic inertia in the management of hyperglycaemia was measured and to assess its extent over the past decade. MATERIALS AND METHODS: Systematic searches for articles published from 1 January 2004 to 1 August 2016 were conducted in MEDLINE and Embase...
August 22, 2017: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/28832853/assessment-of-pharmaceutical-services-in-a-southern-brazilian-city
#20
Raqueli Altamiranda Bittencourt, Marysabel Pinto Telis Silveira, Marília Cruz Guttier, Fernanda Fernandes Miranda, Andréa Dâmaso Bertoldi
Introduction: Well-planned and executed pharmaceutical services (PS) are important for proper treatment of the population's health needs, thus enabling the access to essential drugs and promoting their rational use. Objective: To assess the situation of PS in the city of Uruguaiana (State of Rio Grande do Sul), Brazil. Methods: This cross-sectional study was applied to 650 interviews between June and September of 2013 in 11 Basic Health Units (UBS) and in the Main Pharmacy of the city...
April 2017: Revista Brasileira de Epidemiologia, Brazilian Journal of Epidemiology
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