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https://www.readbyqxmd.com/read/28631525/polyphenol-profile-by-uhplc-ms-ms-anti-glycation-antioxidant-and-cytotoxic-activities-of-several-samples-of-propolis-from-the-northeastern-semi-arid-region-of-brazil
#1
Jadriane de Almeida Xavier, Iara Barros Valentim, Fabiana O S Camatari, Alberto M M de Almeida, Henrique Fonseca Goulart, Jamylle Nunes de Souza Ferro, Emiliano de Oliveira Barreto, Bruno Coelho Cavalcanti, Carla B G Bottoli, Marília Oliveira Fonseca Goulart
CONTEXT: Propolis has promising biological activities. Propolis samples from the Northeast of Bahia, Brazil - sample A from Ribeira do Pombal and B, from Tucano - were investigated, with new information regarding their biological activities. OBJECTIVE: This paper describes the chemical profile, antioxidant, anti-glycation and cytotoxic activities of these propolis samples. MATERIAL AND METHODS: Ethanol extracts of these propolis samples (EEP) and their fractions were analyzed to determine total phenolic content (TPC); antioxidant capacity through DPPH(•), FRAP and lipid peroxidation; anti-glycation activity, by an in vitro glucose (10 mg/mL) bovine serum albumine (1 mg/mL) assay, during 7 d; cytotoxic activity on cancer (SF295, HCT-116, OVCAR-8, MDA-MB435, MX-1, MCF7, HL60, JURKAT, MOLT-4, K562, PC3, DU145) and normal cell lines (V79) at 0...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/28628464/early-evidence-for-zika-virus-circulation-among-aedes-aegypti-mosquitoes-rio-de-janeiro-brazil
#2
Tania Ayllón, Renata de Mendonça Campos, Patrícia Brasil, Fernanda Cristina Morone, Daniel Cardoso Portela Câmara, Guilherme Louzada Silva Meira, Egbert Tannich, Kristie Aimi Yamamoto, Marilia Sá Carvalho, Renata Saraiva Pedro, Jonas Schmidt-Chanasit, Daniel Cadar, Davis Fernandes Ferreira, Nildimar Alves Honório
During 2014-2016, we conducted mosquito-based Zika virus surveillance in Rio de Janeiro, Brazil. Results suggest that Zika virus was probably introduced into the area during May-November 2013 via multiple in-country sources. Furthermore, our results strengthen the hypothesis that Zika virus in the Americas originated in Brazil during October 2012-May 2013.
August 15, 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/28623690/candidate-cytochrome-p450-genes-for-ethoxyresorufin-o-deethylase-activity-in-oyster-crassostrea-gigas
#3
Marília Nardelli Siebert, Jacó Joaquim Mattos, Guilherme Toledo-Silva, Guilherme Razzera, Afonso Celso Dias Bainy
Vertebrate cytochrome P450 1 (CYP1) enzymes metabolize endogenous and xenobiotic compounds and usually demonstrate a substrate-inducible response. Ethoxyresorufin O-deethylase activity (EROD) is a common method to quantify CYP1 enzymes activity in these organisms. Despite the absence of this gene family in protostomes, CYP1-like genes were identified in several species, even though no evolutionary relationship has been established with the vertebrate CYP1 family. In the present study, EROD activity was evaluated in microsomal fraction of gills, digestive gland and mantle of Crassostrea gigas...
June 9, 2017: Aquatic Toxicology
https://www.readbyqxmd.com/read/28623681/soft-tissue-changes-measured-with-three-dimensional-software-provides-new-insights-for-surgical-predictions
#4
Yu-Jen Chang, Antônio C O Ruellas, Marilia S Yatabe, Philip M Westgate, Lucia H S Cevidanes, Sarandeep S Huja
PURPOSE: Although computer-aided craniofacial reconstructions allows for simulation of hard tissue changes, the prediction of the final soft tissue facial changes remains a challenge. The purpose of the present study was to evaluate the 3-dimensional (3D) soft tissue changes in patients undergoing 2-jaw orthognathic surgery. PATIENTS AND METHODS: For the present retrospective cohort study, 40 consecutive patients (11 men and 29 women; mean age 23.5 ± 4.9 years) who had undergone 2-jaw orthognathic surgery were selected...
May 24, 2017: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28622550/effect-of-gels-containing-chlorhexidine-or-epigallocatechin-3-gallate-on-the-protein-composition-of-the-acquired-enamel-pellicle
#5
Cíntia Maria de Souza-E-Silva, Talita Mendes da Silva Ventura, Luiza de Pau, la Silva Cassiano, Aline de Lima Leite, Marília Afonso Rabelo Buzalaf
OBJECTIVE: This study evaluated changes in protein profile of the acquired enamel pellicle (AEP) formed in vivo, after application of gels containing chlorhexidine or EGCG and further challenge with citric acid. DESIGN: AEP was formed in 9 volunteers for 2h and then treated with one of the following gels: placebo, 400μM EGCG or 0.012% chlorhexidine. A thin layer of gel was applied and after 1min the excess was removed. One hour after gel application, the AEP was collected from the buccal surface (upper and lower jaw) of one of the sides with filter paper dipped in 3% citric acid...
June 3, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/28621488/effects-of-intradialytic-neuromuscular-electrical-stimulation-on-strength-and-muscle-architecture-in-patients-with-chronic-kidney-failure-randomized-clinical-trial
#6
Jociane Schardong, Thiago Dipp, Camila Bassani Bozzeto, Marília Godoy da Silva, Gabriela Leivas Baldissera, Raíssa de Castro Ribeiro, Bruna Pan Valdemarca, Alexandre Severo do Pinho, Graciele Sbruzzi, Rodrigo Della Méa Plentz
This study aimed to evaluate the effects of neuromuscular electrical stimulation (NMES) on muscle strength and architecture, functional capacity, and endothelial function in patients with chronic kidney failure (CKF) on hemodialysis (HD). Twenty-one patients with CKF on HD were randomized into a control group (CG; n = 10) and neuromuscular electrical stimulation group (NMESG; n = 11) who received NMES in the quadriceps muscle for 8 weeks, 3 times/week (20-34 min) during HD sessions. The muscle strength of the lower limbs was evaluated by dynamometry and sit-and-stand test (SST); muscle architecture through ultrasonography; functional capacity by the distance covered in a 6-min walk test and the endothelial function by flow-mediated dilatation technique of the brachial artery...
June 16, 2017: Artificial Organs
https://www.readbyqxmd.com/read/28614714/dectin-1-activation-exacerbates-obesity-and-insulin-resistance-in-the-absence-of-myd88
#7
Angela Castoldi, Vinicius Andrade-Oliveira, Cristhiane Favero Aguiar, Mariane Tami Amano, Jennifer Lee, Marcelli Terumi Miyagi, Marcela Teatin Latância, Tarcio Teodoro Braga, Marina Burgos da Silva, Aline Ignácio, Joanna Darck Carola Correia Lima, Flavio V Loures, José Antonio T Albuquerque, Marina Barguil Macêdo, Rafael Ribeiro Almeida, Jonas W Gaiarsa, Luis A Luévano-Martínez, Thiago Belchior, Meire Ioshie Hiyane, Gordon D Brown, Marcelo A Mori, Christian Hoffmann, Marília Seelaender, Willian T Festuccia, Pedro Manoel Moraes-Vieira, Niels Olsen Saraiva Câmara
The underlying mechanism by which MyD88 regulates the development of obesity, metainflammation, and insulin resistance (IR) remains unknown. Global deletion of MyD88 in high-fat diet (HFD)-fed mice resulted in increased weight gain, impaired glucose homeostasis, elevated Dectin-1 expression in adipose tissue (AT), and proinflammatory CD11c+ AT macrophages (ATMs). Dectin-1 KO mice were protected from diet-induced obesity (DIO) and IR and had reduced CD11c+ AT macrophages. Dectin-1 antagonist improved glucose homeostasis and decreased CD11c+ AT macrophages in chow- and HFD-fed MyD88 KO mice...
June 13, 2017: Cell Reports
https://www.readbyqxmd.com/read/28614381/the-cytotoxic-effect-of-tif4-and-naf-on-fibroblasts-is-influenced-by-the-experimental-model-fluoride-concentration-and-exposure-time
#8
Priscila Maria Aranda Salomão, Flávia Amadeu de Oliveira, Paula Danielle Rodrigues, Luana Polioni Al-Ahj, Kellen Cristina da Silva Gasque, Pia Jeggle, Marilia Afonso Rabelo Buzalaf, Rodrigo Cardoso de Oliveira, John Michael Edwardson, Ana Carolina Magalhães
OBJECTIVE: Titanium tetrafluoride (TiF4) has shown promising effect in preventing tooth lesions. Therefore, we compared the cytotoxicity of TiF4 with sodium fluoride (NaF) (already applied in Dentistry) considering different fluoride concentrations, pH values and experimental models. MATERIALS AND METHODS: Step 1) NIH/3T3 fibroblasts were exposed to mediums containing NaF or TiF4 (from 0.15 to 2.45% F), both at native and adjusted pH, for 6 h. Step 2) NIH/3T3 were exposed to NaF or TiF4 varnishes with 0...
2017: PloS One
https://www.readbyqxmd.com/read/28612092/involvement-of-cytochrome-p450-in-cisplatin-treatment-implications-for-toxicity
#9
REVIEW
Júlia Coelho França Quintanilha, Vanessa Marcilio de Sousa, Marília Berlofa Visacri, Laís Sampaio Amaral, Roseane Maria Maia Santos, Tomás Zambrano, Luis Antonio Salazar, Patricia Moriel
PURPOSE: The aim of this study is to evaluate the relationship between the CYP450 enzyme family and cisplatin toxicity. METHODS: This article examined a collection of studies suggesting that CYP450 enzymes may influence cisplatin toxicity. We performed a narrative mini-review. RESULTS: The studies review showed that CYP450 enzymes have an important role in drug-induced hepatotoxicity and nephrotoxicity, mainly CYP2E1 and CYP4A11. The studies also suggested that the cisplatin and CYP2E1 interaction leads to the generation of reactive oxygen species (ROS) and other oxidants resulting in renal injury; and that ROS generated by both the use of cisplatin and by the CYP2E1 increases tissue damage, induces apoptosis, and causes liver failure...
June 13, 2017: Cancer Chemotherapy and Pharmacology
https://www.readbyqxmd.com/read/28601647/metalloproteomic-and-differential-expression-in-plasma-in-a-rat-model-of-type-1-diabetes
#10
Camila Pereira Braga, José Cavalcante Souza Vieira, Aline de Lima Leite, Ana Angélica Henrique Fernandes, Marília Afonso Rabelo Buzalaf, Pedro de Magalhães Padilha
Type 1 diabetes is characterized by hyperglycemia, which in the chronic stage is associated with abnormalities in lipids, protein and, carbohydrate metabolism, as well as oxidative stress. New strategies for prevention and treatment are needed, as type 1 diabetes affects life quality and survival, and involves high-cost treatment. Proteomic and metalloproteomic studies can elucidate the functional and physiological aspects of biomolecules. In the present study, differential proteomics was used to identify potential biomarkers of diabetes in rat plasma associated with copper, selenium, zinc, and magnesium fractionation in control and diabetic rats, as well as diabetic rats treated with insulin...
June 8, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28598896/assessing-pathophysiology-of-cancer-anorexia
#11
Alessandro Laviano, Angela Koverech, Marilia Seelaender
PURPOSE OF REVIEW: Cancer anorexia is a negative prognostic factor and is broadly defined as the loss of the interest in food. However, multiple clinical domains contribute to the phenotype of cancer anorexia. The characterization of the clinical and molecular pathophysiology of cancer anorexia may enhance the efficacy of preventive and therapeutic strategies. RECENT FINDINGS: Clinical trials showed that cancer anorexia should be considered as an umbrella encompassing different signs and symptoms contributing to appetite disruption in cancer patients...
June 8, 2017: Current Opinion in Clinical Nutrition and Metabolic Care
https://www.readbyqxmd.com/read/28591268/diagnosis-of-mycobacteria-in-bovine-milk-an-overview
#12
Carmen Alicia Daza Bolaños, Carolina Lechinski de Paula, Simony Trevizan Guerra, Marília Masello Junqueira Franco, Márcio Garcia Ribeiro
Tuberculosis remains as the world's biggest threat. In 2014, human tuberculosis ranked as a major infectious disease by the first time, overcoming HIV death rates. Bovine tuberculosis is a chronic disease of global distribution that affects animals and can be transmitted to humans by the consumption of raw milk, representing a serious public health concern. Despite the efforts of different countries to control and eradicate bovine tuberculosis, the high negative economic impact on meat and milk production chains remains, given the decreased production efficiency (approximately 25%), the high number of condemned carcasses, and increased animal culling rates...
June 5, 2017: Revista do Instituto de Medicina Tropical de São Paulo
https://www.readbyqxmd.com/read/28586504/removal-of-persistent-cellular-deposits-after-foldable-iris-fixated-phakic-iol-implantation
#13
Marilia Lordello Passos, Ramon Coral Ghanem, Vinícius Coral Ghanem
PURPOSE: To report a case of severe recurrent cellular deposits after Artiflex intraocular lens (Ophtec B. V., Groningen, The Netherlands) implantation. METHODS: Case report. RESULTS: A 25-year-old woman underwent uneventful Artiflex intraocular lens implantation in both eyes. After 3 months, severe cellular deposits were seen in the posterior surface of the lens in one eye. Topical steroids were administered, with temporary improvement. Four months later, the deposits recurred and did not respond to topical steroids...
June 1, 2017: Journal of Refractive Surgery
https://www.readbyqxmd.com/read/28585767/computational-insights-into-the-ch3cl-oh-chemical-reaction-dynamics-at-the-air-water-interface
#14
Manuel Ruiz-Lopez, Marilia Martins-Costa, Josep M Anglada
The reaction of methyl chloride with the hydroxyl radical OH is an important process in the troposphere. The kinetics of this reaction has been thoroughly studied in the gas phase, both experimentally and theoretically, but little is known about the effect of water on this reaction. In particular, investigating the reaction mechanism at the air-water interface is key in order to better understand the role of cloud water droplets and aerosols on the overall oxidation capacity of the troposphere. In this work, we have implemented a "rare event" approach combined to QM/MM (Quantum Mechanics and Molecular Mechanics) Molecular Dynamics simulations to investigate the dynamics of the H-abstraction reaction CH3Cl + OH → CH2Cl + H2O at the air-water interface...
June 6, 2017: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
https://www.readbyqxmd.com/read/28571055/-intera%C3%A3-%C3%A3%C2%B5es-medicamentosas-potenciais-e-risco-de-medicamentos-durante-a-gravidez-e-amamenta%C3%A3-%C3%A3-o-um-estudo-observacional-em-unidade-de-terapia-intensiva
#15
Amanda Canato Ferracini, Aline Teotonio Rodrigues, Marília Berlofa Visacri, Rebeca Stahlschmidt, Nice Maria Oliveira da Silva, Fernanda Garanhani Surita, Priscila Gava Mazzola
Introdução No ciclo gravídico-puerperal, as mulheres podem desenvolver complicações que necessitam de internação na Unidade de Terapia Intensiva (UTI). Assim, é necessária uma atenção especial à farmacoterapia, particularmente às interações medicamentosas potenciais (IMPs) e ao risco dos medicamentos para o feto e o recém-nascido. Objetivo Determinar o perfil das IMPs e o risco potencial dos medicamentos utilizados durante a gravidez e a amamentação entre as mulheres internadas em UTI...
June 1, 2017: Revista Brasileira de Ginecologia e Obstetrícia
https://www.readbyqxmd.com/read/28568475/factors-associated-with-functional-capacity-in-hemodialysis-patients
#16
Rodrigo Schinniger Assun Garcia, Leda Marília Fonseca Lucinda, Fábio Amaral Ramos, Gabriela de Souza Bueno, Gustavo Moreira Ribeiro de Oliveira, Lígia Sant'Ana Bonisson, Marco Antonio Silva, Thomaz Izola Zolli, Bruno Valle Pinheiro, Rogério Baumgratz de Paula, José Muniz Pazeli, Maycon Moura Reboredo
Hemodialysis patients have a marked decrease in functional capacity when compared to healthy individuals. We evaluated the factors associated with functional capacity in hemodialysis patients. A total of 102 hemodialysis patients were evaluated. The patients were submitted to a 6-min walk test, peripheral muscle strength tests, and an evaluation of quality of life, anxiety, and depression. The laboratory data were measured. The 6-min walk test distance correlated significantly with age, educational level, hemoglobin, creatinine, number of comorbidities, peripheral muscle strength, and some domains of SF-36 quality of life questionnaire and depression (P < 0...
June 1, 2017: Artificial Organs
https://www.readbyqxmd.com/read/28566085/prevalence-of-autoantibodies-against-cellular-antigens-in-patients-with-hiv-and-leprosy-coinfection-in-the-amazon-region
#17
Clea Nazaré Carneiro Bichara, Carlos David Araújo Bichara, Camila Tostes, Marinete Marins Povoa, Juarez Antonio Simões Quaresma, Marília Brasil Xavier
BACKGROUND: Infectious agents can activate self-reactive T cells. In general, infections trigger various mechanisms, including a lack of auto-tolerance, induction of costimulatory molecules on antigen presenting cells, and molecular simulation, in addition to cross-reactions between microbial antigens and self-antigens. HIV and leprosy coinfections lead to self-immunity with the production of autoantibodies. However, not enough data on the immune behaviour associated with this coinfection are available...
June 1, 2017: Infectious Diseases of Poverty
https://www.readbyqxmd.com/read/28564584/hydroalcoholic-extract-from-nerium-oleander-l-apocynaceae-elicits-arrhythmogenic-activity
#18
Ana Flávia Machado Botelho, Artur Santos-Miranda, Humberto Cavalcante Joca, Cláudio Roberto Scabelo Mattoso, Maira Souza de Oliveira, Felipe Pierezan, Jader Santos Cruz, Benito Soto-Blanco, Marília Martins Melo
ETHNOPHARMACOLOGICAL RELEVANCE: Nerium oleander L. (OLE) has been used medicinally and is reported to possess a wide range of pharmacological activities. OLE effects are caused by different cardiac glycosides (CG), primarily oleandrin, found within the plant. CG can potentially impair sodium-potassium ATPase (NKA) pump activity and cause positive inotropic effects on the heart. AIM OF THE STUDY: The aim of this study was to investigate the potential arrhythmogenic effects of hydroalcoholic extracts from N...
May 28, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28559594/cassava-derivatives-in-ice-cream-formulations-effects-on-physicochemical-physical-and-sensory-properties
#19
Daiana de Souza Fernandes, Magali Leonel, Marilia Sbragia Del Bem, Martha Maria Mischan, Émerson Loli Garcia, Thaís Paes Rodrigues Dos Santos
In the present study, the effects of derivatives of cassava, maltodextrin and bagasse, on the physicochemical, physical and sensory properties of ice creams were investigated. The content of cassava maltodextrin increased significantly the content of carbohydrate and total soluble solids and decreased lipids content. The effect of cassava bagasse was more pronounced than the maltodextrin on physical and sensory parameters. Increased percentage of cassava bagasse in formulation led to decrease of overrun, melting and luminosity, but increased hardness and unfreezable water...
May 2017: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/28558149/mandibulofacial-dysostosis-bauru-type-refining-the-phenotype
#20
Priscila P Moura, Nancy M Kokitsu-Nakata, Marília S Yatabe, Siulan Vendramini-Pittoli, Pedro H Hori, Maria L Guion-Almeida, Daniela G Garib, Antonio Richieri-Costa, Roseli M Zechi-Ceide
Mandibulofacial dysostosis (MFD) Bauru type (OMIM 604830) is a rare genetic condition characterized mainly by malar hypoplasia, orofacial cleft, and micrognathia. Here, we describe the clinical and radiographic sings of 13 individuals (12 female and 1 male) from eight unrelated kindreds with MFD Bauru type, including four previously reported cases, treated at the Hospital for Rehabilitation of Craniofacial Anomalies. The clinical phenotype was characterized by severe underdevelopment of mandible, midface hypoplasia, orofacial cleft, bitemporal narrowing, mild upper eyelid down slanting, high nasal bridge, thick and everted lower lip, minor ears abnormalities, and hearing loss...
May 30, 2017: American Journal of Medical Genetics. Part A
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