keyword
MENU ▼
Read by QxMD icon Read
search

impaired cognitive function

keyword
https://www.readbyqxmd.com/read/28535277/sensory-impairments-and-cognitive-function-in-middle-aged-adults
#1
Carla R Schubert, Karen J Cruickshanks, Mary E Fischer, Yanjun Chen, Barbara E K Klein, Ronald Klein, A Alex Pinto
Background: Hearing, visual, and olfactory impairments have been associated with cognitive impairment in older adults but less is known about associations with cognitive function in middle-aged adults. Methods: Sensory and cognitive functions were measured on participants in the baseline examination (2005-2008) of the Beaver Dam Offspring Study. Cognitive function was measured with the Trail Making tests A (TMTA) and B (TMTB) and the Grooved Peg Board test. Pure-tone audiometry, Pelli-Robson letter charts, and the San Diego Odor Identification test were used to measure hearing, contrast sensitivity, and olfaction, respectively...
May 23, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/28534952/effects-of-exercise-on-mature-or-precursor-brain%C3%A2-derived-neurotrophic-factor-pathways-in-ovariectomized-rats
#2
Joon-Ki Park, Young-Pyo Hong, Sam-Jun Lee
Ovariectomy (OVX) is a method used to block estrogen in female rats that induces hippocampal dysfunction and affects brain‑derived neurotrophic factor (BDNF) pathways. The majority of previous studies investigating OVX focused on BDNF expression in the hippocampus and cognitive function. The present study focused on the pathways of each BDNF type, precursor (proBDNF) and mature (mBDNF), and the effects of regular exercise in the hippocampus of ovariectomized rats. Female Sprague‑Dawely rats were used and OVX surgery was performed...
May 19, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28534935/effect-of-fasudil-on-cognitive-function-following-status-convulsion-in-rats
#3
Rong He, Wei Han, Xiaojie Song, Xiaoju Tang, Li Cheng, Li Jiang
Fasudil has been demonstrated to possess a protective effect in neural injury; however, its protective effect on convulsive brain injury remains to be assessed. The aim of the present study was to investigate the latent mechanism and effect of fasudil on cognitive function following status convulsion (SC) in rats. Initially, to determine the effects of SC, the expression levels of Ras homolog gene family, member A (RhoA)/Rho‑associated protein kinase (ROCK) signaling pathway‑associated proteins were measured by western blot analysis in 16 rats...
May 19, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28533388/selective-lowering-of-synapsins-induced-by-oligomeric-%C3%AE-synuclein-exacerbates-memory-deficits
#4
Megan E Larson, Susan J Greimel, Fatou Amar, Michael LaCroix, Gabriel Boyle, Mathew A Sherman, Hallie Schley, Camille Miel, Julie A Schneider, Rakez Kayed, Fabio Benfenati, Michael K Lee, David A Bennett, Sylvain E Lesné
Mounting evidence indicates that soluble oligomeric forms of amyloid proteins linked to neurodegenerative disorders, such as amyloid-β (Aβ), tau, or α-synuclein (αSyn) might be the major deleterious species for neuronal function in these diseases. Here, we found an abnormal accumulation of oligomeric αSyn species in AD brains by custom ELISA, size-exclusion chromatography, and nondenaturing/denaturing immunoblotting techniques. Importantly, the abundance of αSyn oligomers in human brain tissue correlated with cognitive impairment and reductions in synapsin expression...
May 22, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28533191/mir-34a-knockout-attenuates-cognitive-deficits-in-app-ps1-mice-through-inhibition-of-the-amyloidogenic-processing-of-app
#5
Chongdong Jian, Mengru Lu, Zhao Zhang, Long Liu, Xianfeng Li, Fang Huang, Ning Xu, Lina Qin, Qian Zhang, Donghua Zou
The noncoding miRNA-34a (miR-34a) is involved in Alzheimer's disease (AD) pathologenesis and shows potential for application as a biomarker for early diagnosis and intervention. Here, we established miR-34a knockout mice in an APP/PS1 background (APP/PS1-miR-34a KO mice) by crossbreeding miR-34a(-/-) mice with APP/PS1 mice. We then investigated cognitive impairment and related pathologies. The results showed that the level of miR-34a was increased at about 6months in APP/PS1 mice, consistent with the increase in amyloid β (Aβ), and cognitive function was significantly improved in mice when miR-34a was knocked out in 9-month-old and 12-month-old mice, indicating that miR-34a is a potential candidate for determining the progression of AD...
May 19, 2017: Life Sciences
https://www.readbyqxmd.com/read/28533141/common-and-distinctive-patterns-of-cognitive-dysfunction-in-children-with-benign-epilepsy-syndromes
#6
Dazhi Cheng, Xiuxian Yan, Zhijie Gao, Keming Xu, Xinlin Zhou, Qian Chen
BACKGROUND: Childhood absence epilepsy and benign childhood epilepsy with centrotemporal spikes are the most common forms of benign epilepsy syndromes. Although cognitive dysfunctions occur in children with both childhood absence epilepsy and benign childhood epilepsy with centrotemporal spikes, the similarity between their patterns of underlying cognitive impairments is not well understood. To describe these patterns, we examined multiple cognitive functions in children with childhood absence epilepsy and benign childhood epilepsy with centrotemporal spikes...
January 4, 2017: Pediatric Neurology
https://www.readbyqxmd.com/read/28531379/the-association-between-an-inflammatory-diet-and-global-cognitive-function-and-incident-dementia-in-older-women-the-women-s-health-initiative-memory-study
#7
Kathleen M Hayden, Daniel P Beavers, Susan E Steck, James R Hebert, Fred K Tabung, Nitin Shivappa, Ramon Casanova, JoAnn E Manson, Claudia B Padula, Elena Salmoirago-Blotcher, Linda G Snetselaar, Oleg Zaslavsky, Stephen R Rapp
INTRODUCTION: The Mediterranean and Dietary Approaches to Stop Hypertension diets have been associated with lower dementia risk. We evaluated dietary inflammatory potential in relation to mild cognitive impairment (MCI)/dementia risk. METHODS: Baseline food frequency questionnaires from n = 7085 women (aged 65-79 years) were used to calculate Dietary Inflammatory Index (DII) scores that were categorized into four groups. Cognitive function was evaluated annually, and MCI and all-cause dementia cases were adjudicated centrally...
May 19, 2017: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://www.readbyqxmd.com/read/28531307/following-instructions-in-patients-with-schizophrenia-the-benefits-of-actions-at-encoding-and-recall
#8
Simon S Y Lui, Tian-Xiao Yang, Chris L Y Ng, Peony T Y Wong, Jessica O Y Wong, Ulrich Ettinger, Eric F C Cheung, Raymond C K Chan
The ability to follow spoken instructions is important to everyday functioning but has seldom been studied in patients with schizophrenia (SZ). Recent evidence suggests that action-based processing may facilitate the ability to follow instructions, which relies largely on working memory. In this study, we tested the hypothesis that SZ patients may also benefit from action-based advantages in following instructions. Forty-eight clinically stable SZ patients and 48 demographic- and IQ-matched controls completed a following spoken instruction span task involving varied encoding and recall conditions...
May 22, 2017: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/28531243/increased-postural-sway-during-quiet-stance-as-a-risk-factor-for-prospective-falls-in-community-dwelling-elderly-individuals
#9
Jonas Johansson, Anna Nordström, Yngve Gustafson, Göran Westling, Peter Nordström
Objective: fall-related injuries constitute major health risks in older individuals, and these risks are projected to increase in parallel with increasing human longevity. Impaired postural stability is a potential risk factor related to falls, although the evidence is inconclusive, partly due to the lack of prospective studies. This study aimed to investigate how objective measures of postural sway predict incident falls. Design, setting and participants: this prospectively observational study included 1,877 community-dwelling individuals aged 70 years who participated in the Healthy Ageing Initiative between June 2012 and December 2015...
May 22, 2017: Age and Ageing
https://www.readbyqxmd.com/read/28529872/functional-network-changes-and-cognitive-control-in-schizophrenia
#10
Kimberly L Ray, Tyler A Lesh, Amber M Howell, Taylor P Salo, J Daniel Ragland, Angus W MacDonald, James M Gold, Steven M Silverstein, Deana M Barch, Cameron S Carter
Cognitive control is a cognitive and neural mechanism that contributes to managing the complex demands of day-to-day life. Studies have suggested that functional impairments in cognitive control associated brain circuitry contribute to a broad range of higher cognitive deficits in schizophrenia. To examine this issue, we assessed functional connectivity networks in healthy adults and individuals with schizophrenia performing tasks from two distinct cognitive domains that varied in demands for cognitive control, the RiSE episodic memory task and DPX goal maintenance task...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28529533/low-expression-of-cd39-and-cd73-genes-in-centenarians-compared-with-octogenarians
#11
Almudena Crooke, Juan Martínez-Henández, Joaquín Martínez-López, Alfonso Cruz-Jentoft, Fernando Huete-Toral, Jesús Pintor
Ageing involves a progressive decline of the body's regulatory systems including immune system. Adenosine regulates immune function by interaction with its receptors, mainly adenosine A2A receptor, present on the surface of immune cells. Furthermore, cellular response to this nucleoside is highly dependent on its extracellular concentration that is regulated by ecto-enzymes such as CD39 and CD73. Therefore, the aim of this study was to investigate the effect of age on adenosine A2A receptor, CD39 and CD73 gene expression...
2017: Immunity & Ageing: I & A
https://www.readbyqxmd.com/read/28529531/the-protective-effect-of-lavender-essential-oil-and-its-main-component-linalool-against-the-cognitive-deficits-induced-by-d-galactose-and-aluminum-trichloride-in-mice
#12
Pan Xu, Kezhu Wang, Cong Lu, Liming Dong, Li Gao, Ming Yan, Silafu Aibai, Yanyan Yang, Xinmin Liu
Lavender essential oil (LO) is a traditional medicine used for the treatment of Alzheimer's disease (AD). It was extracted from Lavandula angustifolia Mill. This study was designed to investigate the effects of lavender essential oil (LO) and its active component, linalool (LI), against cognitive impairment induced by D-galactose (D-gal) and AlCl3 in mice and to explore the related mechanisms. Our results revealed that LO (100 mg/kg) or LI (100 mg/kg) significantly protected the cognitive impairments as assessed by the Morris water maze test and step-though test...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28529459/cold-inducible-rna-binding-protein-is-involved-in-chronic-hypoxia-induced-neuron-apoptosis-by-down-regulating-hif-1%C3%AE-expression-and-regulated-by-microrna-23a
#13
Xiaoming Chen, Xinqin Liu, Bin Li, Qian Zhang, Jiye Wang, Wenbin Zhang, Wenjing Luo, Jingyuan Chen
Background: Neuron apoptosis mediated by hypoxia inducible factor 1α (HIF-1α) in hippocampus is one of the most important factors accounting for the chronic hypobaric hypoxia induced cognitive impairment. As a neuroprotective molecule that is up-regulated in response to various environmental stress, CIRBP was reported to crosstalk with HIF-1α under cellular stress. However, its function under chronic hypobaric hypoxia remains unknown. Objective: In this study, we tried to identify the role of CIRBP in HIF-1α mediated neuron apoptosis under chronic hypobaric hypoxia and find a possible method to maintain its potential neuroprotective in long-term high altitude environmental exposure...
2017: International Journal of Biological Sciences
https://www.readbyqxmd.com/read/28529242/hyperuricemia-as-a-protective-factor-for-mild-cognitive-impairment-in-non-obese-elderly
#14
Feng Wang, Minghui Zhao, Zhaoli Han, Dai Li, Shishuang Zhang, Yongqiang Zhang, Xiaodong Kong, Ning Sun, Qiang Zhang, Ping Lei
Mild cognitive impairment (MCI) is regarded as incipient dementia. Patients with MCI have increased risk of later progressing to dementia. Blood uric acid (UA) is an important non-enzymatic antioxidant in peripheral circulation, and plays an unconfirmed protective role in MCI. Furthermore, obesity-induced inflammation, which affects UA metabolism and MCI onset, might regulate such protective role. Thus, the aim of the study was to determine the relationship of UA to MCI and the potential effect from inflammation...
2017: Tohoku Journal of Experimental Medicine
https://www.readbyqxmd.com/read/28529220/clinical-correlates-of-treatment-response-among-patients-with-schizophrenia-in-a-tertiary-nigerian-hospital
#15
Mark Sunday Ezeme, Richard Uwakwe, Appolos Chidi Ndukuba, Monday N Igwe, Paul Chigozie Odinka, Kennedy Amadi, Nichodemus O Obayi
A significant proportion of patients treated for schizophrenia respond poorly to medication. Few studies have systematically examined the impact of clinical characteristics of patients to antipsychotic response in our environment. The study aimed to identify clinical variables associated with response in patients with schizophrenia. A total of 172 participants diagnosed with schizophrenia, placed on antipsychotics, who presented for the first time to the hospital or have stopped medication in the preceding six months, whose responses were assessed after four to six weeks were studied...
2017: Journal of Health Care for the Poor and Underserved
https://www.readbyqxmd.com/read/28529052/prenatal-melamine-exposure-induces-impairments-of-spatial-cognition-and-hippocampal-synaptic-plasticity-in-female-adolescent-rats
#16
Lei An, Wei Sun
Developmental exposure to melamine induces long-term effects on brain and behavior in male rodents. To examine whether this prenatal event damages cognitive function in female offspring, we evaluated the behavioral effects and further attempted to investigate synaptic function. Prenatal melamine exposure (PME) was given by oral treatment to pregnant females through the whole gestational days with 400mg/day/kg bodyweight. On postnatal day (PD) 36, female offspring were assessed for spatial cognition in the Morris Water Maze (MWM) test...
May 18, 2017: Neurotoxicology
https://www.readbyqxmd.com/read/28528774/local-to-remote-cortical-connectivity-in-amnestic-mild-cognitive-impairment
#17
Yi-Wen Zhang, Zhi-Lian Zhao, Zhigang Qi, Yang Hu, Yin-Shan Wang, Can Sheng, Yu Sun, Xiaoni Wang, Li-Li Jiang, Chao-Gan Yan, Kuncheng Li, Hui-Jie Li, Xi-Nian Zuo
Alterations in both local and remote connectivity were reported in amnestic mild cognitive impairment (aMCI) patients but rarely in the same group of patients. In the present study, we employed a novel resting-state functional magnetic resonance imaging (rfMRI) connectome index, regional functional homogeneity on the 2-dimensional cortical surface, to detect full-cortex vertex-wise changes of the local rfMRI connectivity in 32 aMCI patients compared with 40 healthy controls. We further used the seed-based functional connectivity to explore the remote rfMRI connectivity in aMCI...
April 26, 2017: Neurobiology of Aging
https://www.readbyqxmd.com/read/28528555/development-and-evaluation-of-the-adhd-cognitions-scale-for-adults
#18
Laura E Knouse, John T Mitchell, Nathan A Kimbrel, Arthur D Anastopoulos
OBJECTIVE: The clinical literature on ADHD in adults suggests that "overly positive" or optimistic cognitions may contribute to impairment and failure to use self-regulation skills in this population, yet the research literature on this topic is limited. We developed the ADHD Cognitions Scale (ACS), a brief self-report measure of ADHD-related thoughts, and evaluated its psychometric properties. METHOD: We collected self-report measures, inculding the ACS, from two large community samples ( Ns = 262, 304)...
May 1, 2017: Journal of Attention Disorders
https://www.readbyqxmd.com/read/28528243/overvalued-ideation-in-adolescents-with-obsessive-compulsive-disorder
#19
Tania Borda, Fugen Neziroglu, William Taboas, Dean McKay, Leah Frenkiel
In Obsessive Compulsive Disorder (OCD), overvalued ideas (OVI) are considered poor prognostic indicators in adults. To date, OVI has not been studied in an adolescent population with OCD, nor has it been examined in relation to obsessive-compulsive beliefs. To investigate the relationship between OVI and specific cognitions, fifty-five adolescents with OCD (35 male; 20 female; age range 13-17 years; M=14.05 years, SD=1.75 years) participated. It was predicted that OVI would be associated with symptom severity and would moderate obsessive-compulsive beliefs and functional disability...
May 3, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28528231/neurocognitive-dysfunction-in-problem-gamblers-with-co-occurring-antisocial-personality-disorder
#20
Austin W Blum, Eric W Leppink, Jon E Grant
OBJECTIVES: Problem gamblers with symptoms of antisocial personality disorder (ASPD) may represent a distinct problem gambling subtype, but the neurocognitive profile of individuals affected by both disorders is poorly characterized. METHOD: Non-treatment-seeking young adults (18-29years) who gambled ≥5 times in the preceding year were recruited from the general community. Problem gamblers (defined as those meeting ≥1 DSM-5 diagnostic criteria for gambling disorder) with a lifetime history of ASPD (N=26) were identified using the Mini International Neuropsychiatric Interview (MINI) and compared with controls (N=266) using questionnaire-based impulsivity scales and objective computerized neuropsychological tasks...
May 12, 2017: Comprehensive Psychiatry
keyword
keyword
69111
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"