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https://www.readbyqxmd.com/read/28858134/desflurane-versus-sevoflurane-in-pediatric-anesthesia-with-a-laryngeal-mask-airway-a-randomized-controlled-trial
#1
RANDOMIZED CONTROLLED TRIAL
Eun-Hee Kim, In-Kyung Song, Ji-Hyun Lee, Hee-Soo Kim, Hyun-Chang Kim, Soo-Hyuk Yoon, Young-Eun Jang, Jin-Tae Kim
BACKGROUND: Desflurane with a laryngeal mask airway may have advantages during ambulatory anesthesia. However, desflurane-induced airway irritability makes the use of desflurane challenging, especially in children. This study compared desflurane with sevoflurane maintenance anesthesia in terms of respiratory events and the emergence characteristics in children with a laryngeal mask airway. METHODS: This randomized controlled trial evaluated 200 children undergoing strabismus surgery allocated to desflurane or sevoflurane groups...
September 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28516057/comparison-of-atracurium-and-methocarbamol-for-preventing-succinylcholine-induced-muscle-fasciculation-a-randomized-controlled-trial
#2
Gholamreza Shabanian, Mohammadreza Shabanian, Alireza Shabanian, Saeid Heidari-Soureshjani
Fasciculation is a minor adverse effect of succinylcholine and may be an unpleasant experience for patient. The aim of this study was to compare the use of atracurium and methocarbamol to decrease the occurrence and severity of succinylcholine-induced muscle fasciculation. Fifty-nine adults with American Society of Anesthesiologists I or II hospitalized for elective surgery were randomly assigned to two groups: Group A (n = 29) who received succinylcholine 1 mg/kg body weight (BW) intravenously followed by 0...
April 2017: Journal of Advanced Pharmaceutical Technology & Research
https://www.readbyqxmd.com/read/28511420/effect-of-intraperitoneal-injection-of-saffron-on-the-treatment-of-experimental-endotoxin-induced-uveitis-in-the-rabbit
#3
Mohammad Reza Talebnejad, Kazem Soltanzadeh, Eghtedari Masoomeh, Masoud Yasemi, Mohammad Reza Khalili, Sherafat Maryam
INTRODUCTION: Saffron with scientific name of "Crocus sativus" from the family "Iridaceae" is a plant without stem and root. Antioxidative and immunomodulatory effects of saffron has been demonstrated in different studies. AIM: To assess the effects of saffron in the treatment on Lipopolysaccharide (LPS) induced uveitis in the rabbit. MATERIALS AND METHODS: Thirty healthy female New Zealand white rabbits were prepared. LPS induced uveitis was confirmed via slit lamp examination 24 hours after intravitreal injection of Salmonella typhimurium LPS endotoxin in the right eye of all rabbits...
March 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28414657/death-by-propofol
#4
James H Diaz, Alan David Kaye
Since its introduction in 1986, propofol ( two, 6-diisopropylphenol) , an intravenous sedative-hypnotic agent, has been utilized for the induction and maintenance of general anesthesia and conscious sedation in over 80 percent of cases; largely replacing thiopental ( sodium pentothal) over a decade ago. Unrestricted as a controlled substance, propofol's abuse potential emerged quickly and was highlighted by the death of pop singer, Michael Jackson, in 2009. In order to assess the epidemiological features of fatal propofol abuse, a descriptive analysis of the scientific literature was conducted using Internet search engines...
March 2017: Journal of the Louisiana State Medical Society: Official Organ of the Louisiana State Medical Society
https://www.readbyqxmd.com/read/28277329/sevoflurane-compared-with-isoflurane-minimizes-lung-damage-in-pulmonary-but-not-in-extrapulmonary-acute-respiratory-distress-syndrome-in-rats
#5
COMPARATIVE STUDY
Mariana N Araújo, Cíntia L Santos, Cynthia S Samary, Luciana B B Heil, Vinicius C M Cavalcanti, Fernanda F Cruz, Nathane S Felix, Johnatas D Silva, Marcelo M Morales, Paolo Pelosi, Fatima C Fernandes, Nivaldo R Villela, Pedro L Silva, Patricia R M Rocco
BACKGROUND: Volatile anesthetics modulate inflammation in acute respiratory distress syndrome (ARDS). However, it is unclear whether they act differently depending on ARDS etiology. We hypothesized that the in vivo and in vitro effects of sevoflurane and isoflurane on lung damage would not differ in pulmonary (p) and extrapulmonary (exp) ARDS. METHODS: Twenty-four Wistar rats were randomized to undergo general anesthesia (1-2 minutes) with sevoflurane and isoflurane...
August 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28252609/-the-morphological-changes-in-the-myocardium-associated-with-the-craniocerebral-injury
#6
G A Boyarinov, A V Deryugina, R R Zaitsev, E I Yakovleva, V O Nikol'sky, L V Boyarinova, M V Galkina
The objective of the present study was to evaluate the structural changes in the capillaries, arterioles, venules, and cardiomyocytes in the myocardium of the rats following the craniocerebral injury (CCI). Eighteen non-pedigree white female rats with the craniocerebral injury were used as the CCI model. All the animals were given an intraperitoneal injection of sodium thiopental (100 mg/kg b.w.) within 3, 7, and 12 days after the injury. The heart was removed after thoracotomy and the myocardial tissue was examined with the light and electron microscopes...
2017: Sudebno-meditsinskaia Ekspertiza
https://www.readbyqxmd.com/read/28155226/propofol-versus-thiopental-sodium-for-the-treatment-of-refractory-status-epilepticus
#7
REVIEW
Hemanshu Prabhakar, Mani Kalaivani
BACKGROUND: This review is an update of a previously published review in the Cochrane Database of Systematic Reviews (Issue 6, 2015).Failure to respond to antiepileptic drugs in patients with uncontrolled seizure activity such as refractory status epilepticus (RSE) has led to the use of anaesthetic drugs. Coma is induced with anaesthetic drugs to achieve complete control of seizure activity. Thiopental sodium and propofol are popularly used for this purpose. Both agents have been found to be effective...
February 3, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28079825/the-utility-of-bispectral-index-monitoring-for-prevention-of-rocuronium-induced-withdrawal-movement-in-children-a-randomized-controlled-trial
#8
RANDOMIZED CONTROLLED TRIAL
Byung Gun Lim, Il Ok Lee, Young Sung Kim, Young Ju Won, Heezoo Kim, Myoung Hoon Kong
BACKGROUND: This study was designed to determine whether a deep hypnotic state with a bispectral index (BIS) value less than 40 could alleviate withdrawal movement (WM) upon rocuronium injection during anesthesia induction in children. METHODS: Finally, 135 healthy children (3-12 years) scheduled for minor elective surgery were studied. Without premedication, anesthesia was induced with thiopental sodium 5 mg/kg. Patients were randomized into 2 groups (control vs experimental) and then by virtue of rocuronium injection time, patients in the experimental group were allocated into 2 groups, as follows: in the control group (group C; n = 45), rocuronium 0...
January 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28076314/in-vivo-sedative-and-hypnotic-activities-of-methanol-extract-from-the-leaves-of-jacquemontia-paniculata-burm-f-hallier-f-in-swiss-albino-mice
#9
Md Jakaria, Chayan Dhar Clinton, Mukimul Islam, Mohammad Belal Talukder, Md Shariful Islam, Syed Mohammed Tareq, Shaikh Bokhtear Uddin
BACKGROUND: The superior genus Jacquemontia belongs to Convolvulaceae, with around 120 species, and is also considered taxonomically difficult. The aim of this experiment was to assess the sedative and hypnotic activities of methanol extract from the leaves of Jacquemontia paniculata (Burm.f.) Hallier f. METHODS: The sedative and hypnotic activities were evaluated by hole-cross, open field, hole-board, elevated plus maze (EPM), and thiopental sodium-induced sleeping time determination tests in mice at doses of 200 and 400 mg/kg...
March 1, 2017: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/28040235/-the-effect-of-palonosetron-on-rocuronium-induced-withdrawal-movement
#10
Ki-Bum Park, Younghoon Jeon, Junggu Yi, Ji-Hyun Kim, Seung-Yeon Chung, Kyung-Hwa Kwak
BACKGROUND: Rocuronium causes pain and withdrawal movement during induction of anesthesia. In this study, palonosetron was investigated to have analgesic effect on the reduction of rocuronium-induced withdrawal movement. METHODS: 120 patients were randomly assigned to one of three groups to receive either saline, lidocaine 20mg, or palonosetron 0.075mg with a tourniquet applied two minutes before thiopental sodium (5mg·kg(-1)) was given intravenously. After loss of consciousness, rocuronium (0...
December 29, 2016: Revista Brasileira de Anestesiologia
https://www.readbyqxmd.com/read/27909593/our-anaesthetic-experiences-in-patients-undergoing-percutaneous-mitraclip-implantation
#11
Ezgi Erkılıç, Elvin Kesimci, Cihan Döğer, Tülin Gümüş, Süleyman Ellik, Orhan Kanbak
OBJECTIVE: Percutaneous mitraclip implantation system, is a new technique developed for patients with high surgical risks. It is generally performed in a catheterisation laboratory with the guidance of fluoroscopy and transesophageal echocardiography. In this study, we aimed to share our experiences on anaesthetic in patients undergoing mitraclip implantation under general anaesthesia. METHODS: Eighty four patients with severe, symptomatic mitral insufficiency, who had undergone MitraClip implantation under general anaesthesia between July 2012 and March 2015 (54 male, 30 female; mean age: 68...
August 2016: Turkish Journal of Anaesthesiology and Reanimation
https://www.readbyqxmd.com/read/27769218/in-vivo-sedative-activity-of-methanolic-extract-of-stericulia-villosa-roxb-leaves
#12
Md Forhad Hossain, Bashudeb Talukder, Mohammad Nasiruddin Rana, Refat Tasnim, Tanzina Sharmin Nipun, S M Naim Uddin, S M Moazzem Hossen
BACKGROUND: This plant is very popular ingredient of local made drinks during hot summer. After drinking this drink people feels fresh, relaxed and can enjoy sound sleep. Present study was aimed to assess the sedative properties of a plant Sterculia villosa leaves. Therefore, we tried to find out the methanolic extract from the leaves of Sterculia villosa leaves having any sedative activity or not. METHODS: The extract were subjected to various in vivo methods like hole cross test, open field test, elevated plus-maze (EPM) test, thiopental sodium induced sleeping time test...
October 21, 2016: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/27742301/long-time-choledochal-clamping-in-wistar-rats-causes-biliary-obstruction-progressing-to-hepatic-fibrosis
#13
G D L Jorge, R R Tártaro, C A F Escanhoela, I D F S F Boin
BACKGROUND: Biliary complications are important causes of morbidity and mortality in patients undergoing hepatic surgery. The aim of the study was to evaluate late liver alterations after a long period of choledochal clamping in Wistar rats. METHODS: Ten male Wistar rats, weighing 304 grams, anesthetized with sodium thiopental (25 mg/kg) and xylazine (10 mg/kg) intravenously, were distributed into 2 groups: the choledochal clamping group (CCG) and the operation sham group (OSG), with 5 animals each submitted to an abdominal incision...
September 2016: Transplantation Proceedings
https://www.readbyqxmd.com/read/27685364/a-light-meal-three-hours-preoperatively-decreases-the-incidence-of-gastro-esophageal-reflux-in-dogs
#14
RANDOMIZED CONTROLLED TRIAL
Ioannis Savvas, Dimitrios Raptopoulos, Timoleon Rallis
Emerging evidence from veterinary and medical clinical research shows that reducing preoperative fasting time may reduce the incidence of gastro-esophageal reflux (GER) intraoperatively. In order to evaluate the effect of two different preoperative fasting times on the incidence of GER during general anesthesia, 120 dogs were randomly assigned to two groups: administration of canned food 3 h before premedication (group C3, n = 60) and administration of canned food 10 h before premedication (group C10, n = 60)...
November 2016: Journal of the American Animal Hospital Association
https://www.readbyqxmd.com/read/27597405/synthesis-biological-evaluation-and-molecular-modeling-study-of-thiadiazolo-3-2-a-1-3-diazepine-analogues-of-hie-124-as-a-new-class-of-short-acting-hypnotics
#15
Hussein I El-Subbagh, Ghada S Hassan, Kamal E H El-Taher, Shahenda M El-Messery, Adel S Al-Azab, Alaa A-M Abdelaziz, Mohamed M Hefnawy
A new series of 6,7-dihydro-[1,3,4]thiadiazolo[3,2-a][1,3]diazepine analogues were synthesized, and biological evaluated. Compound GS-62 (33) exhibited potent in vivo short acting hypnotic activity with onset time, duration of sleep and therapeutic index of 6.4 ± 0.2, 94.8 ± 5.3 min, 6.62, respectively), in comparison to thiopental sodium (6). Compounds 33 did not show any sign of acute tolerance reported with the maintenance dose of 6. Meanwhile 33 potentiated the in vivo hypnotic effect of 6 in an equimolar amounts (0...
November 29, 2016: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/27548910/is-neuromuscular-blocker-necessary-in-pediatric-patients-undergoing-laparoscopic-inguinal-hernia-repair-with-percutaneous-internal-ring-suturing
#16
Ali Ahiskalioglu, İlker İnce, Elif Oral Ahiskalioglu, Akgun Oral, Mehmet Aksoy, Murat Yiğiter, Mehmet Emin Celikkaya, Ahmet Bedii Salman
Purpose The aim of this study is to evaluate operating conditions during general anesthesia with or without neuromuscular blocker (NMB) in patients undergoing percutaneous internal ring suturing (PIRS). Materials and Methods In this study, 40 patients, with American Society of Anesthesiologists I and II between the ages of 1 and 12 years, were randomly assigned to two groups to receive muscle relaxant with endotracheal tube (ETT) (ETT group) or without muscle relaxant with supreme laryngeal mask airway (sLMA) (LMA group)...
June 2017: European Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/27488151/effect-of-thiamine-pyrophosphate-on-retinopathy-induced-by-hyperglycemia-in-rats-a-biochemical-and-pathological-evaluation
#17
Emine Cinici, Ibrahim Ahiskali, Nihal Cetin, Bahadir Suleyman, Osman Kukula, Durdu Altuner, Abdulkadir Coban, Hilal Balta, Mehmet Kuzucu, Halis Suleyman
PURPOSE: Information is lacking on the protective effects of thiamine pyrophosphate (TPP) against hyperglycemia-induced retinopathy in rats. This study investigated the biochemical and histopathological aspects of the effect of TPP on hyperglycemia-induced retinopathy induced by alloxan in rats. MATERIALS AND METHODS: The rats were separated into a diabetic TPP-administered group (DTPG), a diabetes control group (DCG) and a healthy group (HG). While the DTPG was given TPP, the DCG and HG were administered distilled water as a solvent at the same concentrations...
June 2016: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/27413390/sedative-and-anxiolytic-like-actions-of-ethanol-extract-of-leaves-of-glinus-oppositifolius-linn-aug-dc
#18
Md Moniruzzaman, Partha Sharoti Bhattacharjee, Moushumi Rahman Pretty, Md Sarwar Hossain
Glinus oppositifolius is a small herb, widely used in the traditional medicine of Bangladesh in treatment of a variety of diseases and disorders such as insomnia, pain, inflammation, jaundice, and fever. The present study evaluated the sedative and anxiolytic potentials of the ethanol extract of leaves of G. oppositifolius (EEGO) in different behavioral models in mice. The sedative activity of EEGO was investigated using hole cross, open field, rotarod, and thiopental sodium- (TS-) induced sleeping time determination tests, where the elevated plus maze (EPM) and light-dark box (LDB) exploration tests were employed to justify the anxiolytic potentials in mice at the doses of 50, 100, and 200 mg/kg...
2016: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/27388495/gastro-oesophageal-reflux-in-large-sized-deep-chested-versus-small-sized-barrel-chested-dogs-undergoing-spinal-surgery-in-sternal-recumbency
#19
Tilemahos L Anagnostou, George M Kazakos, Ioannis Savvas, Charalampos Kostakis, Paraskevi Papadopoulou
OBJECTIVE: The aim of this study was to investigate whether an increased frequency of gastro-oesophageal reflux (GOR) is more common in large-sized, deep-chested dogs undergoing spinal surgery in sternal recumbency than in small-sized, barrelchested dogs. STUDY DESIGN: Prospective, cohort study. ANIMALS: Nineteen small-sized, barrel-chested dogs (group B) and 26 large-sized, deep-chested dogs (group D). METHODS: All animals were premedicated with intramuscular (IM) acepromazine (0...
January 2017: Veterinary Anaesthesia and Analgesia
https://www.readbyqxmd.com/read/27306661/splenic-artery-embolization-with-ankaferd-blood-stopper-in-a-sheep-model
#20
Osman Koç, Kadir Acar, Orhan Özbek, İbrahim Güler, Kadir Sarıtaş, Tuba Bera Erdem, Yalçın Solak, Hatice Toy, Ahmet Küçükapan, Seda Özbek, Abduzhappar Gaipov, İbrahim C Haznedaroğlu
PURPOSE: Splenic artery embolization is a minimally invasive therapeutic procedure utilized in a number of disorders. Ankaferd blood stopper (ABS) is a novel hemostatic agent with a new mechanism of action independent of clotting factors. We aimed to investigate the safety and efficiency of ABS for splenic artery embolization in a sheep model. METHODS: Seven adult female sheep were included in the study. Selective celiac angiography was performed using a 5F diagnostic catheter and then a 2...
July 2016: Diagnostic and Interventional Radiology: Official Journal of the Turkish Society of Radiology
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