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thiopental sodium

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https://www.readbyqxmd.com/read/28079825/the-utility-of-bispectral-index-monitoring-for-prevention-of-rocuronium-induced-withdrawal-movement-in-children-a-randomized-controlled-trial
#1
Byung Gun Lim, Il Ok Lee, Young Sung Kim, Young Ju Won, Heezoo Kim, Myoung Hoon Kong
BACKGROUND: This study was designed to determine whether a deep hypnotic state with a bispectral index (BIS) value less than 40 could alleviate withdrawal movement (WM) upon rocuronium injection during anesthesia induction in children. METHODS: Finally, 135 healthy children (3-12 years) scheduled for minor elective surgery were studied. Without premedication, anesthesia was induced with thiopental sodium 5 mg/kg. Patients were randomized into 2 groups (control vs experimental) and then by virtue of rocuronium injection time, patients in the experimental group were allocated into 2 groups, as follows: in the control group (group C; n = 45), rocuronium 0...
January 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28076314/in-vivo-sedative-and-hypnotic-activities-of-methanol-extract-from-the-leaves-of-jacquemontia-paniculata-burm-f-hallier-f-in-swiss-albino-mice
#2
Md Jakaria, Chayan Dhar Clinton, Mukimul Islam, Mohammad Belal Talukder, Md Shariful Islam, Syed Mohammed Tareq, Shaikh Bokhtear Uddin
BACKGROUND: The superior genus Jacquemontia belongs to Convolvulaceae, with around 120 species, and is also considered taxonomically difficult. The aim of this experiment was to assess the sedative and hypnotic activities of methanol extract from the leaves of Jacquemontia paniculata (Burm.f.) Hallier f. METHODS: The sedative and hypnotic activities were evaluated by hole-cross, open field, hole-board, elevated plus maze (EPM), and thiopental sodium-induced sleeping time determination tests in mice at doses of 200 and 400 mg/kg...
January 11, 2017: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/28040235/-the-effect-of-palonosetron-on-rocuronium-induced-withdrawal-movement
#3
Ki-Bum Park, Younghoon Jeon, Junggu Yi, Ji-Hyun Kim, Seung-Yeon Chung, Kyung-Hwa Kwak
BACKGROUND: Rocuronium causes pain and withdrawal movement during induction of anesthesia. In this study, palonosetron was investigated to have analgesic effect on the reduction of rocuronium-induced withdrawal movement. METHODS: 120 patients were randomly assigned to one of three groups to receive either saline, lidocaine 20mg, or palonosetron 0.075mg with a tourniquet applied two minutes before thiopental sodium (5mg·kg(-1)) was given intravenously. After loss of consciousness, rocuronium (0...
December 28, 2016: Revista Brasileira de Anestesiologia
https://www.readbyqxmd.com/read/27909593/our-anaesthetic-experiences-in-patients-undergoing-percutaneous-mitraclip-implantation
#4
Ezgi Erkılıç, Elvin Kesimci, Cihan Döğer, Tülin Gümüş, Süleyman Ellik, Orhan Kanbak
OBJECTIVE: Percutaneous mitraclip implantation system, is a new technique developed for patients with high surgical risks. It is generally performed in a catheterisation laboratory with the guidance of fluoroscopy and transesophageal echocardiography. In this study, we aimed to share our experiences on anaesthetic in patients undergoing mitraclip implantation under general anaesthesia. METHODS: Eighty four patients with severe, symptomatic mitral insufficiency, who had undergone MitraClip implantation under general anaesthesia between July 2012 and March 2015 (54 male, 30 female; mean age: 68...
August 2016: Turkish Journal of Anaesthesiology and Reanimation
https://www.readbyqxmd.com/read/27769218/in-vivo-sedative-activity-of-methanolic-extract-of-stericulia-villosa-roxb-leaves
#5
Md Forhad Hossain, Bashudeb Talukder, Mohammad Nasiruddin Rana, Refat Tasnim, Tanzina Sharmin Nipun, S M Naim Uddin, S M Moazzem Hossen
BACKGROUND: This plant is very popular ingredient of local made drinks during hot summer. After drinking this drink people feels fresh, relaxed and can enjoy sound sleep. Present study was aimed to assess the sedative properties of a plant Sterculia villosa leaves. Therefore, we tried to find out the methanolic extract from the leaves of Sterculia villosa leaves having any sedative activity or not. METHODS: The extract were subjected to various in vivo methods like hole cross test, open field test, elevated plus-maze (EPM) test, thiopental sodium induced sleeping time test...
October 21, 2016: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/27742301/long-time-choledochal-clamping-in-wistar-rats-causes-biliary-obstruction-progressing-to-hepatic-fibrosis
#6
G D L Jorge, R R Tártaro, C A F Escanhoela, I D F S F Boin
BACKGROUND: Biliary complications are important causes of morbidity and mortality in patients undergoing hepatic surgery. The aim of the study was to evaluate late liver alterations after a long period of choledochal clamping in Wistar rats. METHODS: Ten male Wistar rats, weighing 304 grams, anesthetized with sodium thiopental (25 mg/kg) and xylazine (10 mg/kg) intravenously, were distributed into 2 groups: the choledochal clamping group (CCG) and the operation sham group (OSG), with 5 animals each submitted to an abdominal incision...
September 2016: Transplantation Proceedings
https://www.readbyqxmd.com/read/27685364/a-light-meal-three-hours-preoperatively-decreases-the-incidence-of-gastro-esophageal-reflux-in-dogs
#7
Ioannis Savvas, Dimitrios Raptopoulos, Timoleon Rallis
Emerging evidence from veterinary and medical clinical research shows that reducing preoperative fasting time may reduce the incidence of gastro-esophageal reflux (GER) intraoperatively. In order to evaluate the effect of two different preoperative fasting times on the incidence of GER during general anesthesia, 120 dogs were randomly assigned to two groups: administration of canned food 3 h before premedication (group C3, n = 60) and administration of canned food 10 h before premedication (group C10, n = 60)...
November 2016: Journal of the American Animal Hospital Association
https://www.readbyqxmd.com/read/27597405/synthesis-biological-evaluation-and-molecular-modeling-study-of-thiadiazolo-3-2-a-1-3-diazepine-analogues-of-hie-124-as-a-new-class-of-short-acting-hypnotics
#8
Hussein I El-Subbagh, Ghada S Hassan, Kamal E H El-Taher, Shahenda M El-Messery, Adel S Al-Azab, Alaa A-M Abdelaziz, Mohamed M Hefnawy
A new series of 6,7-dihydro-[1,3,4]thiadiazolo[3,2-a][1,3]diazepine analogues were synthesized, and biological evaluated. Compound GS-62 (33) exhibited potent in vivo short acting hypnotic activity with onset time, duration of sleep and therapeutic index of 6.4 ± 0.2, 94.8 ± 5.3 min, 6.62, respectively), in comparison to thiopental sodium (6). Compounds 33 did not show any sign of acute tolerance reported with the maintenance dose of 6. Meanwhile 33 potentiated the in vivo hypnotic effect of 6 in an equimolar amounts (0...
November 29, 2016: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/27548910/is-neuromuscular-blocker-necessary-in-pediatric-patients-undergoing-laparoscopic-inguinal-hernia-repair-with-percutaneous-internal-ring-suturing
#9
Ali Ahiskalioglu, İlker İnce, Elif Oral Ahiskalioglu, Akgun Oral, Mehmet Aksoy, Murat Yiğiter, Mehmet Emin Celikkaya, Ahmet Bedii Salman
Purpose The aim of this study is to evaluate operating conditions during general anesthesia with or without neuromuscular blocker (NMB) in patients undergoing percutaneous internal ring suturing (PIRS). Materials and Methods In this study, 40 patients, with American Society of Anesthesiologists I and II between the ages of 1 and 12 years, were randomly assigned to two groups to receive muscle relaxant with endotracheal tube (ETT) (ETT group) or without muscle relaxant with supreme laryngeal mask airway (sLMA) (LMA group)...
August 22, 2016: European Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/27488151/effect-of-thiamine-pyrophosphate-on-retinopathy-induced-by-hyperglycemia-in-rats-a-biochemical-and-pathological-evaluation
#10
Emine Cinici, Ibrahim Ahiskali, Nihal Cetin, Bahadir Suleyman, Osman Kukula, Durdu Altuner, Abdulkadir Coban, Hilal Balta, Mehmet Kuzucu, Halis Suleyman
PURPOSE: Information is lacking on the protective effects of thiamine pyrophosphate (TPP) against hyperglycemia-induced retinopathy in rats. This study investigated the biochemical and histopathological aspects of the effect of TPP on hyperglycemia-induced retinopathy induced by alloxan in rats. MATERIALS AND METHODS: The rats were separated into a diabetic TPP-administered group (DTPG), a diabetes control group (DCG) and a healthy group (HG). While the DTPG was given TPP, the DCG and HG were administered distilled water as a solvent at the same concentrations...
June 2016: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/27413390/sedative-and-anxiolytic-like-actions-of-ethanol-extract-of-leaves-of-glinus-oppositifolius-linn-aug-dc
#11
Md Moniruzzaman, Partha Sharoti Bhattacharjee, Moushumi Rahman Pretty, Md Sarwar Hossain
Glinus oppositifolius is a small herb, widely used in the traditional medicine of Bangladesh in treatment of a variety of diseases and disorders such as insomnia, pain, inflammation, jaundice, and fever. The present study evaluated the sedative and anxiolytic potentials of the ethanol extract of leaves of G. oppositifolius (EEGO) in different behavioral models in mice. The sedative activity of EEGO was investigated using hole cross, open field, rotarod, and thiopental sodium- (TS-) induced sleeping time determination tests, where the elevated plus maze (EPM) and light-dark box (LDB) exploration tests were employed to justify the anxiolytic potentials in mice at the doses of 50, 100, and 200 mg/kg...
2016: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/27388495/gastro-oesophageal-reflux-in-large-sized-deep-chested-versus-small-sized-barrel-chested-dogs-undergoing-spinal-surgery-in-sternal-recumbency
#12
Tilemahos L Anagnostou, George M Kazakos, Ioannis Savvas, Charalampos Kostakis, Paraskevi Papadopoulou
OBJECTIVE: The aim of this study was to investigate whether an increased frequency of gastro-oesophageal reflux (GOR) is more common in large-sized, deep-chested dogs undergoing spinal surgery in sternal recumbency than in small-sized, barrel-chested dogs. STUDY DESIGN: Prospective, cohort study. ANIMALS: Nineteen small-sized, barrel-chested dogs (group B) and 26 large-sized, deep-chested dogs (group D). METHODS: All animals were premedicated with intramuscular (IM) acepromazine (0...
July 7, 2016: Veterinary Anaesthesia and Analgesia
https://www.readbyqxmd.com/read/27306661/splenic-artery-embolization-with-ankaferd-blood-stopper-in-a-sheep-model
#13
Osman Koç, Kadir Acar, Orhan Özbek, İbrahim Güler, Kadir Sarıtaş, Tuba Bera Erdem, Yalçın Solak, Hatice Toy, Ahmet Küçükapan, Seda Özbek, Abduzhappar Gaipov, İbrahim C Haznedaroğlu
PURPOSE: Splenic artery embolization is a minimally invasive therapeutic procedure utilized in a number of disorders. Ankaferd blood stopper (ABS) is a novel hemostatic agent with a new mechanism of action independent of clotting factors. We aimed to investigate the safety and efficiency of ABS for splenic artery embolization in a sheep model. METHODS: Seven adult female sheep were included in the study. Selective celiac angiography was performed using a 5F diagnostic catheter and then a 2...
July 2016: Diagnostic and Interventional Radiology: Official Journal of the Turkish Society of Radiology
https://www.readbyqxmd.com/read/27247914/comparing-clonidine-and-lidocaine-on-attenuation-of-hemodynamic-responses-to-laryngoscopy-and-tracheal-intubation-in-controlled-hypertensive-patients-a-randomized-double-blinded-clinical-trial
#14
Sussan Soltani Mohammadi, Alireza Maziar, Alireza Saliminia
BACKGROUND: Hemodynamic fluctuations in response to laryngoscopy and tracheal intubation and their potential hazards have been well-recognized, especially in hypertensive patients. Many drugs in various combinations have been used to attenuate these adverse responses. OBJECTIVES: We conducted a study to compare lidocaine with clonidine on the attenuation of hemodynamic responses to laryngoscopy and tracheal intubation, in controlled hypertensive patients undergoing general anesthesia...
April 2016: Anesthesiology and Pain Medicine
https://www.readbyqxmd.com/read/27206889/thiopental-sodium-preserves-the-responsiveness-to-glutamate-but-not-acetylcholine-in-rat-primary-cultured-neurons-exposed-to-hypoxia
#15
Tomotaka Morita, Satoshi Shibuta, Jun Kosaka, Yuji Fujino
Although many in vitro studies demonstrated that thiopental sodium (TPS) is a promising neuroprotective agent, clinical attempts to use TPS showed mainly unsatisfactory results. We investigated the neuroprotective effects of TPS against hypoxic insults (HI), and the responses of the neurons to l-glutamate and acetylcholine application. Neurons prepared from E17 Wistar rats were used after 2weeks in culture. The neurons were exposed to 12-h HI with or without TPS. HI-induced neurotoxicity was evaluated morphologically...
June 15, 2016: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/27192084/exercise-ameliorates-endocrine-pancreas-damage-induced-by-chronic-cola-drinking-in-rats
#16
Matilde Otero-Losada, Julián González, Angélica Müller, Graciela Ottaviano, Gabriel Cao, Francisco Azzato, Giuseppe Ambrosio, José Milei
PURPOSE: This study evaluates whether the daily practice of an exercise routine might protect from endocrine pancreas damage in cola drinking rats. METHODS: Forty-eight Wistar rats were randomly assigned to 4 groups depending on a) beverage consumption ad libitum, water (W) or cola beverage (C), and b) physical activity, sedentary (S) or treadmill running (R). Accordingly, 4 groups were studied: WS (water sedentary), WR (water runner), CS (cola sedentary) and CR (cola runner)...
2016: PloS One
https://www.readbyqxmd.com/read/27127737/aqueous-leaf-extract-of-ocimum-gratissimum-improves-hematological-parameters-in-alloxan-induced-diabetic-rats-via-its-antioxidant-properties
#17
Shehu-Tijani Toyin Shittu, Wahab A Oyeyemi, Taye J Lasisi, Seyid Alli-Siise Shittu, Temitope T Lawal, Samuel T Olujobi
OBJECTIVE: This study was designed to investigate the effects of Ocimum gratissimum (OG) on hematological parameters and oxidative stress in diabetic rats. MATERIALS AND METHODS: Twenty-five male rats (150-200 g) were randomly grouped into five as control, normal + OG, diabetic untreated, diabetic + OG, and diabetic + glibenclamide groups. Diabetes was induced by 100 mg/kg of alloxan monohydrate in the diabetic untreated and diabetic + OG groups followed by treatment with distilled water and 400 mg/kg OG, respectively, whereas control, normal + OG, and diabetic + glibenclamide groups were treated with distilled water, 400 mg/kg OG, and 5 mg/kg glibenclamide, respectively...
April 2016: International Journal of Applied and Basic Medical Research
https://www.readbyqxmd.com/read/27110526/effect-of-etomidate-versus-combination-of-propofol-ketamine-and-thiopental-ketamine-on-hemodynamic-response-to-laryngoscopy-and-intubation-a-randomized-double-blind-clinical-trial
#18
Afshin Gholipour Baradari, Abolfazl Firouzian, Alieh Zamani Kiasari, Mohsen Aarabi, Seyed Abdollah Emadi, Ali Davanlou, Nima Motamed, Ensieh Yousefi Abdolmaleki
BACKGROUND: Laryngoscopy and intubation frequently used for airway management during general anesthesia, is frequently associated with undesirable hemodynamic disturbances. OBJECTIVES: The aim of this study was to compare the effects of etomidate, combination of propofol-ketamine and thiopental-ketamine as induction agents on hemodynamic response to laryngoscopy and intubation. PATIENTS AND METHODS: In a double blind, randomized clinical trial a total of 120 adult patients of both sexes, aged 18 - 45 years, scheduled for elective surgery under general anesthesia were randomly assigned into three equally sized groups...
February 2016: Anesthesiology and Pain Medicine
https://www.readbyqxmd.com/read/27053335/comparison-of-sevoflurane-administered-through-a-face-mask-versus-rectal-thiopental-sodium-in-children-undergoing-magnetic-resonance-imaging
#19
Manuel Ángel Gómez-Ríos, Enrique Freire-Vila, Krzysztof M Kuczkowski, Alberto Pensado-Castiñeiras
OBJECTIVE: Sevoflurane (S) and thiopental sodium (T) are commonly used to produce sedation for routine MRI procedures. However, to date there have been no comparative studies evaluating both techniques. We herein present the firt study comparing S and T techniques for pediatric sedation in MRI procedures. MATERIALS AND METHODS: 21 children, aged from 3 months to 6 years, scheduled for MRI were randomly assigned to either S or T group. Sedation performed under spontaneous respiration was induced with inspired 1-8% S in oxigen by face mask connected to a Mapleson C circuit or T (25 mg/kg) administered in distal rectum by cannula...
February 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/27051438/cardiopulmonary-effects-of-thiopental-versus-propofol-as-an-induction-agent-prior-to-isoflurane-anesthesia-in-chair-trained-rhesus-macaques-macaca-mulatta
#20
Yun-Jung Choi, Hye-Jin Park, Hyeon-Ho Kim, Yun-Jin Lee, Kyeong-Cheon Jung, Seong-Hoe Park, Jae-Il Lee
The purpose of this study was to evaluate the effects of thiopental versus propofol on cardiopulmonary functions, when used as an induction agent prior to isoflurane anesthesia in rhesus monkeys. Eight healthy rhesus monkeys weighing 3.72 to 5.7 kg, 4-5 years old, were used in the study. Anesthesia was induced with thiopental or propofol intravenous injection, and then maintained with isoflurane in oxygen for 45 minutes. Cardiopulmonary measurements were obtained before and 5, 15, 30, 45, and 60 minutes after induction...
March 2016: Laboratory Animal Research
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