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https://www.readbyqxmd.com/read/28107577/is-palmoplantar-pustulosis-simply-a-variant-of-psoriasis-or-a-distinct-entity
#1
Magdalena Misiak-Galazka, Hanna Wolska, Lidia Rudnicka
We read with interest the comment of Brunasso and Massone to our review article.(1) We agree that palmoplantar pustulosis (PPP) shares many features with palmoplantar pustular psoriasis (PPPP), and about 1/3 patients with PPP present with psoriasis lesions (skin, nail or joint changes). The close relationship and coexistence of PPP and psoriasis was confirmed in many studies. (3-5) This article is protected by copyright. All rights reserved.
January 20, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28107576/non-invasive-anaesthetic-methods-for-dermatological-laser-procedures-a-systematic-review
#2
REVIEW
K Greveling, E P Prens, L Liu, M B A van Doorn
Pain is a common side-effect of dermatological laser procedures. Non-invasive anaesthetic drugs and anaesthetic procedures can be used to provide pain relief and increase patient satisfaction and treatment efficacy. However, it remains unclear which method provides the best pain relief. The objective of this systematic review was therefore to assess the efficacy and safety of non-invasive anaesthetic methods during dermatological laser procedures. A systematic literature search was conducted. Randomized and non-randomized controlled clinical trials (RCTs and CCTs) were included...
January 20, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28107575/spanish-version-of-actinic-keratosis-quality-of-life-questionnaire-akqol
#3
I Alarcon, G R Vinding, K B Christensen, S Esmann, J Malvehy, S Puig, G B E Jemec
BACKGROUND: Patient Reported Outcome Measures are very important outcomes. For specific diseases Health Related Quality of Life-instruments (HRQoL) are increasingly used to provide data on patients' overall perceptions of the course of a given disease. Actinic keratoses (AKs) are common keratotic lesions that occur on chronically sunlight-exposed skin. Only few studies regarding HRQoL in AKs have been made. OBJECTIVE: In order to be able to compare HRQoL among different countries and cultures we aimed to translate and validate the Actinic Keratosis Quality of Life (AKQoL) questionnaire into Spanish and quantify the impairment caused by AKs in Spanish patients...
January 20, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28107524/the-frequency-spectral-properties-of-electrode-skin-contact-impedance-on-human-head-and-its-frequency-dependent-effects-on-frequency-difference-eit-in-stroke-detection-from-10hz-to-1mhz
#4
Lin Yang, Meng Dai, Canhua Xu, Ge Zhang, Weichen Li, Feng Fu, Xuetao Shi, Xiuzhen Dong
Frequency-difference electrical impedance tomography (fdEIT) reconstructs frequency-dependent changes of a complex impedance distribution. It has a potential application in acute stroke detection because there are significant differences in impedance spectra between stroke lesions and normal brain tissues. However, fdEIT suffers from the influences of electrode-skin contact impedance since contact impedance varies greatly with frequency. When using fdEIT to detect stroke, it is critical to know the degree of measurement errors or image artifacts caused by contact impedance...
2017: PloS One
https://www.readbyqxmd.com/read/28107182/the-nitrobenzoxadiazole-derivative-mc3181-blocks-melanoma-invasion-and-metastasis
#5
Anastasia De Luca, Debora Carpanese, Maria Cristina Rapanotti, Tara Mayte Suarez Viguria, Maria Antonietta Forgione, Dante Rotili, Chiara Fulci, Egidio Iorio, Luigi Quintieri, Sergio Chimenti, Luca Bianchi, Antonio Rosato, Anna Maria Caccuri
The novel nitrobenzoxadiazole (NBD) derivative MC3181 is endowed with remarkable therapeutic activity in mice bearing both sensitive and vemurafenib-resistant human melanoma xenografts. Here, we report that subtoxic concentrations of this compound significantly reduced invasiveness of BRAF-V600D mutated WM115 and WM266.4 melanoma cell lines derived from the primary lesion and related skin metastasis of the same patient, respectively. The strong antimetastatic activity of MC3181 was observed in both 2D monolayer cultures and 3D multicellular tumor spheroids, and confirmed in vivo by the significant decrease in the number of B16-F10 melanoma lung metastases in drug-treated mice...
January 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/28107076/characterization-of-an-avipoxvirus-from-a-bald-eagle-haliaeetus-leucocephalus-using-novel-consensus-pcr-protocols-for-the-rpo147-and-dna-dependent-dna-polymerase-genes
#6
Alexa A Stephen, Angelique M Leone, David E Toplon, Linda L Archer, James F X Wellehan
A juvenile female bald eagle ( Haliaeetus leucocephalus ) was presented with emaciation and proliferative periocular lesions. The eagle did not respond to supportive therapy and was euthanatized. Histopathologic examination of the skin lesions revealed plaques of marked epidermal hyperplasia parakeratosis, marked acanthosis and spongiosis, and eosinophilic intracytoplasmic inclusion bodies. Novel polymerase chain reaction (PCR) assays were done to amplify and sequence DNA polymerase and rpo147 genes. The 4b gene was also analyzed by a previously developed assay...
December 2016: Journal of Avian Medicine and Surgery
https://www.readbyqxmd.com/read/28107063/hematologic-and-biochemical-values-of-wild-red-tailed-amazon-parrot-amazona-brasiliensis-nestlings-with-abnormal-clinical-examination-in-rasa-island-brazil
#7
Frederico Fontanelli Vaz, Rosangela Locatelli-Dittrich, Olair Carlos Beltrame, Elenise Angelotti Bastos Sipinski, Maria Cecília Abbud, Rafael Meirelles Sezerban
The red-tailed Amazon parrot (Amazona brasiliensis) is an endangered psittacine species, but little information is available about abnormal clinical findings and hematologic and biochemical values of this species, which are important for monitoring the health of this population. To determine hematologic and biochemical values for wild red-tailed parrot nestlings exhibiting abnormal clinical findings, 31 nestlings from the Rasa Island (Paraná State, Southern Brazil) were physically restrained for clinical examination and blood sample collection...
December 2016: Journal of Avian Medicine and Surgery
https://www.readbyqxmd.com/read/28106802/effects-of-the-truck-suspension-system-on-animal-welfare-carcass-and-meat-quality-traits-in-pigs
#8
Filipe Antônio Dalla Costa, Letícia S Lopes, Osmar Antônio Dalla Costa
The objective of this study was to assess the effects of two types of commercial suspension (leaf-spring (LS) vs. air suspension (AS)) installed on two similar double-decked trucks on blood cortisol and lactate concentration, lairage behavior, carcass skin lesions and pork quality traits of 120 crossbred pigs. The suspension type neither influenced pig behaviour in lairage nor blood cortisol and lactate concentrations (p > 0.10). However, when compared with the AS suspension system, the use of LS increased the number of skin lesions in the back and thigh (p = 0...
January 18, 2017: Animals: An Open Access Journal From MDPI
https://www.readbyqxmd.com/read/28106291/ocular-effects-of-sulfur-mustard-and-therapeutic-approaches-a-review
#9
Yunes Panahi, Seyyed Mahdi Rajaee, Amirhossein Sahebkar
Sulfur mustard (SM) is a strong blistering, highly reactive, lipophilic chemical war agent that causes injury in different organs including the skin, eyes and respiratory tract. The Eyes are especially susceptible to the consequences of SM poisoning because of the aqueous and mucosal nature of conjunctiva and cornea. DNA alkylation and depletion of glutathione, are the most important mechanisms of SM action in the eye injuries. Acute clinical symptoms are including decrease in visual acuity, dryness, photophobia, blepharospasm, conjunctivitis and complaints of foreign body sensation and soreness that gradually progress to severe ocular pain...
January 20, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28106273/the-immunoglobulin-superfamily-member-cd200r-identifies-cells-involved-in-type-2-immune-responses
#10
Lars H Blom, Britta C Martel, Lau F Larsen, Camilla V Hansen, Malene P Christensen, Nanna Juel-Berg, Thomas Litman, Lars K Poulsen
BACKGROUND: The pathology of allergic diseases involves type 2 immune cells, such as Th2, ILC2, and basophils exerting their effect by production of IL-4, IL-5, and IL-13. However, surface receptors that are specifically expressed on type 2 immune cells are less well documented. The aim of this investigation was to identify surface markers associated with type 2 inflammation. METHODS: Naïve human CD4(+) T-cells were short-term activated in the presence or absence of IL-4, and analysed for expression of >300 cell-surface proteins...
January 20, 2017: Allergy
https://www.readbyqxmd.com/read/28105789/pdgfra-amplification-in-multiple-skin-lesions-of-undifferentiated-pleomorphic-sarcoma-ups-a-clue-for-intimal-sarcoma-metastases
#11
A Osio, M-D Vignon-Pennamen, F Pedeutour, C Le Maignan, F Koskas, C Lebbé, A Janin, M Battistella
A 62-year-old HIV-positive man was admitted for multiple cutaneous and subcutaneous nodules on his lower limbs, corresponding to an undifferentiated proliferation of spindle and pleomorphic cells, with irregular nuclei and numerous mitoses. The tumor cells were negative for a large panel of immunohistochemical markers, except CD10. MDM2 immunohistochemical staining was also negative, leading to the diagnosis of FNCLCC grade III Undifferentiated Pleomorphic Sarcoma (UPS). aCGH showed a highly complex karyotype, with amplification of the 4q12 region, an area that contains only the PDGFRa gene...
January 20, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/28105724/intraepidermal-proliferation-of-merkel-cells-within-a-seborrheic-keratosis-merkel-cell-carcinoma-in-situ-or-merkel-cell-hyperplasia
#12
Jeanne McFalls, Lauren Okon, Sarah Cannon, Jason B Lee
Intradepidermal proliferation of Merkel cells without any dermal component has been interpreted as either a hyperplastic process secondary to chronic ultraviolet radiation (UVR) or a neoplastic process, namely, Merkel cell carcinoma (MCC) in-situ. The recent criteria that have been proffered to diagnose MCC in-situ, unfortunately, are identical to those that have been applied to Merkel cell hyperplasia in the past, posing a diagnostic quandary when faced with an intraepidermal proliferation of Merkel cells...
January 20, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/28104899/amino-acid-based-material-for-the-complementary-therapy-of-decubitus-ulcers
#13
Frederico Nogueira, Isabel C Gouveia
Chronic wounds, pressure sores, lesions and infections of microbial origin in bedridden, paralyzed or malnutrition patients remain the object of study of many researchers. There are several intrinsic and extrinsic factors involved in the development of these disorders, which are related to the patient's immune system, making it unable to respond effectively to the treatment of the wound. These factors can be properly controlled, giving particular importance to the ethiology and stage of the wound, as well as the time periods corresponding to the replacement of the dressings...
January 20, 2017: Journal of Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28104255/nmosd-triggered-by-yellow-fever-vaccination-an-unusual-clinical-presentation-with-segmental-painful-erythema
#14
F Schöberl, E Csanadi, O Eren, M Dieterich, T Kümpfel
Neuromyelitis Optica Spectrum Disorder (NMOSD) is an immune-mediated disease of the central nervous system with the presence of aquaporin 4-antibodies (AQP4-abs) in most cases. We describe a patient who developed NMOSD after a yellow fever vaccination. He presented to us with an unusual painful erythema Th7-9 triggered by touch in the respective skin area due to a cervical spinal cord lesion affecting the dorsolateral parts of C6/7. To our knowledge, this is the first case of NMOSD with such a clinical presentation expanding the clinical spectrum of NMOSD...
January 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/28103910/epithelioid-schwannoma-of-the-skin-displaying-unique-histopathological-features-a-teaching-case-giving-rise-to-diagnostic-difficulties-on-a-morphological-examination-of-a-resected-specimen-with-a-brief-literature-review
#15
Sohsuke Yamada, Mari Kirishima, Tsubasa Hiraki, Michiyo Higashi, Kazuhito Hatanaka, Akihide Tanimoto
BACKGROUND: Epithelioid schwannoma as a rare variant poses a challenge to all pathologists, as this uncommon entity is extremely difficult to conclusively diagnose by morphological analyses on a resected sample alone owing to its unique histopathological features. However, few papers have described the detailed clinicopathological characteristics of epithelioid schwannoma. CASE PRESENTATION: A 65-year-old female presented with a history of a flat and slightly elevated firm and tan plaque accompanied by occasional tenderness, measuring 10 × 8 mm, in the right joint of her hand 1 year before resection...
January 19, 2017: Diagnostic Pathology
https://www.readbyqxmd.com/read/28103792/diagnosis-implications-of-the-whole-genome-sequencing-in-a-large-lebanese-family-with-hyaline-fibromatosis-syndrome
#16
Zahraa Haidar, Ramzi Temanni, Eliane Chouery, Puthen Jitesh, Wei Liu, Rashid Al-Ali, Ena Wang, Francesco M Marincola, Nadine Jalkh, Soha Haddad, Wassim Haidar, Lotfi Chouchane, André Mégarbané
BACKGROUND: Hyaline fibromatosis syndrome (HFS) is a recently introduced alternative term for two disorders that were previously known as juvenile hyaline fibromatosis (JHF) and infantile systemic hyalinosis (ISH). These two variants are secondary to mutations in the anthrax toxin receptor 2 gene (ANTXR2) located on chromosome 4q21. The main clinical features of both entities include papular and/or nodular skin lesions, gingival hyperplasia, joint contractures and osteolytic bone lesions that appear in the first few years of life, and the syndrome typically progresses with the appearance of new lesions...
January 19, 2017: BMC Genetics
https://www.readbyqxmd.com/read/28103501/congenital-embryonal-rhabdomyosarcoma-multiple-lesions
#17
Heidarali Esmaeili, Mahzad Azimpouran
INTRODUCTION: Congenital or neonatal rhabdomyosarcoma (RMS) is a rare soft tissue tumor with the most common sites of origin in genitourinary tract, head, and neck regions and extremities are less commonly involved. PRESENTATION OF CASE: In this paper, a case of embryonal RMS with skin lesions, lymph nodes metastasis, and bone marrow metastasis is reported for a 1-month old female patient. DISCUSSION: This study presents how within 8-months of chemotherapy, the lesions got subsided and the patient became disease free...
January 5, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28102840/cancer-associated-fibroblasts-enact-field-cancerization-by-promoting-extratumoral-oxidative-stress
#18
Jeremy Soon Kiat Chan, Ming Jie Tan, Ming Keat Sng, Ziqiang Teo, Terri Phua, Chee Chong Choo, Liang Li, Pengcheng Zhu, Nguan Soon Tan
Histological inspection of visually normal tissue adjacent to neoplastic lesions often reveals multiple foci of cellular abnormalities. This suggests the presence of a regional carcinogenic signal that spreads oncogenic transformation and field cancerization. We observed an abundance of mutagenic reactive oxygen species in the stroma of cryosectioned patient tumor biopsies, indicative of extratumoral oxidative stress. Diffusible hydrogen peroxide (H2O2) was elevated in the conditioned medium of cultured skin epithelia at various stages of oncogenic transformation, and H2O2 production increased with greater tumor-forming and metastatic capacity of the studied cell lines...
January 19, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28101638/refractory-skin-lesion-hypertension-and-acute-kidney-injury-in-a-young-boy-answers
#19
Valeriya M Feygina, Thomas F Hahn, Dianne G Muchant
No abstract text is available yet for this article.
January 18, 2017: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/28101637/refractory-skin-lesion-hypertension-and-acute-kidney-injury-in-a-young-boy-questions
#20
Valeriya M Feygina, Thomas F Hahn, Dianne G Muchant
No abstract text is available yet for this article.
January 18, 2017: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
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