Read by QxMD icon Read

Skin lesion

F Bath-Hextall, S Nalubega, C Evans
BACKGROUND: Skin cancer incidence is increasing worldwide. This is an update of a previous review published in 2010 that identified only two studies and found that the needs and experiences of individuals with skin cancer were under-researched. OBJECTIVES: To undertake a qualitative systematic review of the needs and experiences of people with a diagnosis of skin cancer. METHODS: As an update of a previous review, the following databases were searched from 2010 to 30/11/15: CINAHL PsycINFO, MEDLINE and EMBASE...
October 24, 2016: British Journal of Dermatology
T-C Chou, K-B Tsai, C-Y Wu, C-H Hong, C-H Lee
We present a case of Merkel cell carcinoma (MCC) coincident with squamous cell carcinoma (SCC) on the breast of a woman with chronic arsenism. This case demonstrates the distinct association of chronic arsenism with two different primary cutaneous carcinomas. Merkel cell polyomavirus (MCPyV) was identified in the lesional skin of the MCC but not in that of the SCC, suggesting there are different interactions of MCPyV in the pathogenesis of SCC and MCC related to arsenic. Physicians need to be vigilant in the occurrence of both SCC and MCC in patients with chronic arsenism...
October 23, 2016: Clinical and Experimental Dermatology
Ying Wang, Lili Wang, Haoyu Yang, Weichang Yuan, Jingyi Ren, Yanping Bai
Circulating T follicular helper (cTfh) cells are known to be involved in numerous immune-mediated diseases, but their pathological role in psoriasis is less fully investigated. Herein, we aimed to identify whether cTfh cells contributed to the pathogenesis of psoriasis. The frequency and function of cTfh cells were compared between patients with psoriasis vulgaris and healthy controls, and the infiltration of Tfh cells was detected between lesional and nonlesional skin tissues of psoriasis patients. Moreover, the dynamic change of cTfh cells before and after acitretin treatment was evaluated...
2016: Journal of Immunology Research
Uzma Jamil, M Usman Akram, Shehzad Khalid, Sarmad Abbas, Kashif Saleem
Digital dermoscopy aids dermatologists in monitoring potentially cancerous skin lesions. Melanoma is the 5th common form of skin cancer that is rare but the most dangerous. Melanoma is curable if it is detected at an early stage. Automated segmentation of cancerous lesion from normal skin is the most critical yet tricky part in computerized lesion detection and classification. The effectiveness and accuracy of lesion classification are critically dependent on the quality of lesion segmentation. In this paper, we have proposed a novel approach that can automatically preprocess the image and then segment the lesion...
2016: BioMed Research International
Sulev Kõks, Maris Keermann, Ene Reimann, Ele Prans, Kristi Abram, Helgi Silm, Gea Kõks, Kulli Kingo
BACKGROUND: Several studies have been published that investigated potential links between transcriptome changes and psoriasis using microarrays and RNA-seq technologies, but no previous study has analyzed expression profile of alternatively spliced transcripts in psoriasis. OBJECTIVES: Identification of potential alternatively spliced RNA isoforms with disease-specific expression profile. METHODS: Using our published RNA sequencing data from lesional psoriatic (LP), non-lesional psoriatic (NLP), and normal control skin (C), we analyzed the differential expression of RNA splicing variants...
2016: Frontiers in Medicine
Nima Mesbah Ardakani, Benjamin A Wood
No abstract text is available yet for this article.
February 2016: Pathology
Sujatha Fernando, Fong Seen Koh, Anna Durie, Anne Gilroy
No abstract text is available yet for this article.
February 2016: Pathology
Andrew Johnston
IL-17-driven pathways are active in the skin of patients with psoriasis. Kim et al. examined lesions from mild and moderate to severe psoriasis and found that differences in cutaneous disease severity may be the outcome of lapses in immunoregulatory mechanisms; because as much, if not more, T helper type 17-induced inflammation was seen in mild psoriasis, these patients may also benefit from anti-IL-17-targeted biologics.
November 2016: Journal of Investigative Dermatology
Pallavi Basu, Anwen Williams, Matthew T O'Brien, Mattheus Brouns, Paul Edwards
A 44-year-old alcoholic, and therefore immunocompromised hospital cleaner presented with general malaise, weight loss, and erythematous skin nodules. CT scanning revealed a neck mass invading the thyroid gland, pulmonary infiltrates, liver lesions and deposits on the anterior abdominal wall, consistent with disseminated malignancy. However, tissue diagnosis showed a necro-inflammatory process with no evidence of malignancy. Microscopy and culture of samples failed to detect any infectious pathogen but after an extended incubation period, Finegoldia magna was isolated...
October 19, 2016: International Journal of Infectious Diseases: IJID
Masamoto Murakami, Kenji Kameda, Hiroki Tsumoto, Teruko Tsuda, Kana Masuda, Ryo Utsunomiya, Hideki Mori, Yuri Miura, Koji Sayama
We previously reported that the early vesicle of the palmoplantar pustulosis (PPP) vesicle originated from eccrine sweat in the acrosyringium, and that the PPP vesicle contains the antimicrobial peptide human cathelicidin (hCAP)-18/LL-37. The concentration of LL-37 was sufficient to induce the subsequent inflammation in lesions and human keratinocytes, and the PPP vesicles contained additional small fragments of hCAP-18, of ∼7 kDa, which have not been identified. The aim of the present study was to clarify the additional processed forms found in PPP vesicles and their physiological effects on normal keratinocytes and sweat gland cells...
October 19, 2016: Journal of Investigative Dermatology
Ge Shi, Ting-Ting Wang, Juan-Hua Quan, Shi-Jie Li, Man-Feng Zhang, Pei-Yu Liao, Yi-Ming Fan
BACKGROUND: The transcription factor Sox9 is pivotal in the morphogenesis of hair follicles, but its role in sebocytes is poorly understood. OBJECTIVE: We investigated the effect of Sox9 on human sebocyte proliferation, differentiation and lipogenesis. METHODS: Sox9 expression was detected by immunohistochemistry in normal skin and acne lesion. Primary cultured human sebocytes were transfected with adenovirus expressing GFP-Sox9 or Sox9 microRNA...
October 13, 2016: Journal of Dermatological Science
M-H Jegou, P Huet, I Penchet
BACKGROUND: Nested melanoma in elderly subjects is an entity that has been reported in the literature only since 2012. In this paper, we describe its distinctive clinical, dermatoscopic and histopathological features and compare them to previous published cases, with the aim of highlighting certain specific criteria of this melanoma subtype. CASE REPORT: A 52-year-old man was referred for the presence on his chest of a large suspicious pigmented lesion of irregular shape and colour...
October 19, 2016: Annales de Dermatologie et de Vénéréologie
S Topin-Ruiz, J-M Debarre, E Blanchard, S Kettani, P-J Valmier, L Martin, Y Le Corre
BACKGROUND: Circumscribed palmar hypokeratosis (CPH) is a rare skin disease, first described in 2002, associated with sudden localized reduction of the corneal layer. In most cases, it presents as an isolated rounded erythematous palmar lesion on the thenar eminence. We describe the dermoscopic semiology of CPH in 3 cases. PATIENTS AND METHODS: Three patients between the ages of 59 and 72 presented very limited erythematous lesions suggestive of CPH. Dermoscopic examination of these lesions provided similar findings...
October 19, 2016: Annales de Dermatologie et de Vénéréologie
Jian Du, Liqing Wang, Yuanxian Wang, Jian Shen, Chuanyin Pan, Yan Meng, Changming Yang, Hong Ji, Wuzi Dong
The outbreak of Chinese Giant Salamander (Andrias davidianus, CGS) Iridovirus (CGSIV) caused massive death of CGSs. However, some CGSs with low level of CGSIV usually could survive. In our study, major capsid protein (MCP) DNA replicates of CGSIV in shedding skin were employed to assess the relative content of CGSIV in the living CGSs by qPCR. Furthermore, the examinations of autophagy and apoptosis in CGSs in vivo and in the primary renal cells in vitro were performed, respectively. The results showed that the relative contents of CGSIV in the shedding skin could reflect those in liver, spleen, and kidney of the CGSs...
November 15, 2016: Veterinary Microbiology
Andreas Keil, Sean R Hall, Meike Körner, Martin Herrmann, Ralph A Schmid, Steffen Frese
BACKGROUND: Since the precise mechanism for the pathogenesis of systemic lupus erythematosus (SLE) is unknown, no targeted therapies in addition to immunosuppression are available so far. We recently demonstrated that administration of the topoisomerase I (topo I) inhibitor irinotecan at extremely low concentrations reversed established lupus nephritis in NZB/NZW mice. While profound immunosuppression was absent, we proposed changes in DNA relaxation and anti-double-stranded (ds)DNA antibody binding as the underlying mechanism...
October 22, 2016: Arthritis Research & Therapy
Victor Monteon, Enrique Quen-Rámirez, Veronica Macedo-Reyes, Ruth Lopez, Karla Acosta-Viana, Pamela Pennigton, Angel Ramos-Ligonio
Under natural conditions, Trypanosoma cruzi infection is transmitted to mammals when faeces contaminated with metacyclic trypomastigotes gain access through skin lesions, mucosa or bite wounds. Natural infection of bugs with T. cruzi can vary greatly from less than 1% up to 70%, depending on triatomine species: in the case of Triatoma dimidiata, the percentage of infection is around 30%. In this work uses biological fluids (saliva and faeces) from Triatoma dimidiata to inoculate experimental animals once or multiple times, before inoculation with faeces contaminated with metacyclic trypomastigotes discrete type unit Ia (TcI)...
October 1, 2016: Annals of Parasitology
Yanhong Li, Xiaolong Sui, Hua Zhu, Yanfeng Xu, Lan Huang, Yuhuan Xu, Yunlin Han, Xiaochun Feng, Chuan Qin
Henoch-Schönlein purpura (HSP) is a systemic vasculitis mediated by autologous immune complex. Animal models of HSP are scarce. Here, we describe the characteristics of HSP rabbit model in the acute and recovery phase. First, we constructed the HSP rabbit models, and then assessed immunologic indicators of models by enzyme-linked immunosorbent assay and immunoturbidimetry. Histomorphological characteristics were analyzed by haematoxylin-eosin, immunofluorescence and special staining. In the acute stage (24 h) after antigen challenge, the model group rabbits featured skin ecchymosis and abnormal laboratory examination results...
October 21, 2016: Archives of Dermatological Research
S E Choon, C F Ngim, S Premaa, K W Tey, M N Nalini
BACKGROUND: Limited information exists regarding paediatric psoriasis and its association with body mass index (bMI) in Asia. OBJECTIVES: to determine the clinico-epidemiological profile and to compare the bMI of children with and without psoriasis. METHODS: A case-control study of 92 children with psoriasis versus 59 with atopic eczema and 56 with non-inflammatory skin conditions. RESULTS: Psoriasis was more common in Malay and Indian children when compared to Chinese with odds ratios (Or) of 4...
August 2016: Medical Journal of Malaysia
Natasha R Catlin, Ron Herbert, Kyathanahalli Janardhan, Milton R Hejtmancik, Laurene M Fomboy, Molly Vallant, Grace E Kissling, Michael J DeVito
Virginia cedarwood oil is widely used as a fragrance material in household and personal products and as a naturally derived pesticide alternative. Due to conflicting literature on dermal exposures in animals and humans, concern for safe levels of human exposure remains. The present study evaluated the toxicity of cedarwood oil applied dermally to F344/N rats and B6C3F1/N mice for 13 weeks. Groups of 10 male and female rats and mice received no treatment (untreated control) or were administered cedarwood oil in 95% aqueous ethanol dermally at concentrations ranging from 0% (vehicle control), 6...
October 18, 2016: Food and Chemical Toxicology
Satomi Igawa, Mari Kishibe, Masako Minami-Hori, Masaru Honma, Hisashi Tsujimura, Junko Ishikawa, Tsutomu Fujimura, Masamoto Murakami, Akemi Ishida-Yamamoto
Atopic dermatitis (AD) is a common inflammatory skin disorder. Chronic AD lesions present hyperkeratosis, indicating a disturbed desquamation process. Kallikrein-related peptidase (KLK) 7 is a serine protease involved in the proteolysis of extracellular corneodesmosome (CD) components, including desmocollin1 and corneodesmosin (Cdsn), which leads to desquamation. KLK7 is secreted by lamellar granules, and upregulated in AD lesional skin. However, despite increased KLK7 protein levels, immunostaining and electron microscopy indicated numerous CDs remaining in the uppermost layer of the stratum corneum (SC) from AD lesions...
October 18, 2016: Journal of Investigative Dermatology
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"