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https://www.readbyqxmd.com/read/29055132/gram-negative-bacterial-toe-web-infection-a-systematic-review
#1
REVIEW
Till Weidner, Jörg Tittelbach, Tanja Illing, Peter Elsner
Gram-negative bacterial toe web infection (GNBTWI) is a frequent therapeutic challenge in clinical practice with high recurrence rates and frequent need of systemic drugs. The aim of this systematic review was to provide an updated overview and evidence-based data on pathogens, risk-factors and treatment of GNBTWI along with promoting a consistent international terminology. This systematic review is based on a search in PubMed database for English and German articles published between 1980 and 2016. A total of 7 articles were considered appropriate for inclusion in this review regarding to treatment and outcome...
October 21, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29054972/endothelial-function-is-impaired-in-the-cutaneous-microcirculation-of-adults-with-psoriasis-through-reductions-in-nitric-oxide-dependent-vasodilation
#2
Billie K Alba, Jody L Greaney, Sara B Ferguson, Lacy M Alexander
Psoriasis is an independent risk factor for cardiovascular disease, however the underlying mechanisms are not fully understood. Deficits in conduit arterial function are evident in psoriatics, but potential impairments in microcirculatory endothelial function remain unclear. We hypothesized that cutaneous microvascular dysfunction would be detectable in otherwise healthy psoriatics. Two intradermal microdialysis fibers were placed in (non-lesional) forearm skin of 9 patients with moderate plaque psoriasis (3M, 6F; 39±5 yr; 16±2 %BSA) and 9 non-psoriatic controls (3M, 6F; 38±5 yr) for local delivery of 1) lactated Ringer's (control) and 2) 10mM L-ascorbate (non-specific antioxidant)...
October 20, 2017: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/29054959/honeycomb-and-necklace-signs-in-liver-abscesses-secondary-to-melioidosis
#3
Sidney Ching Liang Ong, Mina Mustafa Mahmood Alemam, Nor Aniza Zakaria, Nur Azidawati Abdul Halim
Melioidosis is endemic in Southeast Asia and tropical Australia with varying clinical features from benign skin lesions to fatal septicaemia. Imaging plays an important role in evaluation of the melioid liver abscesses. A 45-year-old man with underlying diabetes presented with fever and lethargy for 2 weeks and abdominal pain for 2 days. His liver was enlarged on examination. Blood investigations revealed mild leucocytosis and raised liver enzymes. Ultrasound showed multiple multiloculated hypoechoic lesions throughout the liver and spleen...
October 19, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29054896/metastatic-melanoma-of-unknown-primary-in-the-temporalis-muscle
#4
Marco Dalle Carbonare, Mei Xien Goh, Zainab AlshiekhAli, David Howlett
Melanomas are aggressive cancers that present as cutaneous, mucosal and ocular lesions with the ability to metastasise widely. There are, however, occasions where lesions are found in distant sites such as lymph nodes, viscera and subcutaneous tissues without clinically apparent skin involvement. This is known as metastatic melanoma of unknown primary (MUP). Its presentation in skeletal muscle is rare, and the available literature is sparse. This article presents an 85-year-old woman with a MUP presenting in the right temporalis muscle, which was diagnosed with the aid of the ultrasound-guided core biopsy...
October 20, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29053097/-amputation-of-the-forefoot-in-a-14-year-old-boy-due-to-infiltrative-glomus-tumour
#5
Hoda Khorasani, Claus L Jensen, Christian T Bonde
Glomus tumours are rare dermal tumours, which very seldom can be seen viscerally. The majority is benign small tumours of the skin. Malignancy has been reported in very few cases worldwide. The diagnosis is made clinically supported by MRI-scans and biopsy of the lesion. We present a case story of a 14-year-old boy, who had an infiltrative glomus tumour of the foot. The tumour met the criteria for malignancy and was operated radically by amputation of the forefoot. The post-operative period was uncomplicated and no metastases were observed neither clinically nor by PET-CT scans...
October 16, 2017: Ugeskrift for Laeger
https://www.readbyqxmd.com/read/29052949/the-risks-and-external-effects-of-diabetic-foot-ulcer-on-diabetic-patients-a-hospital-based-survey-in-wuhan-area-china
#6
Aimei Zhong, Gongchi Li, Dan Wang, Yi Sun, Xinghua Zou, Binghui Li
Diabetic foot ulcer (DFU) is a common complication observed in diabetic patients and affects diabetic patients in multiple ways. Severe DFU even leads to amputation in many cases. Early detection and intervention of DFU in diabetic patients can significantly relieve the pain caused by the ulcer and also keep patients from losing limbs in severe cases. In this study, the risks of diabetic patients getting DFU were estimated through a hospital-based survey. This survey collected information from hospitalized diabetic patients in Wuhan City, Hubei Province, China, using a questionnaire...
October 20, 2017: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/29052374/portable-fluorescence-lifetime-spectroscopy-system-for-in-situ-interrogation-of-biological-tissues
#7
Marcelo Saito Nogueira, Alessandro Cosci, Ramon Gabriel Teixeira Rosa, Ana Gabriela Salvio, Sebastião Pratavieira, Cristina Kurachi
Fluorescence spectroscopy and lifetime techniques are potential methods for optical diagnosis and characterization of biological tissues with an in-situ, fast, and noninvasive interrogation. Several diseases may be diagnosed due to differences in the fluorescence spectra of targeted fluorophores, when, these spectra are similar, considering steady-state fluorescence, others may be detected by monitoring their fluorescence lifetime. Despite this complementarity, most of the current fluorescence lifetime systems are not robust and portable, and not being feasible for clinical applications...
October 2017: Journal of Biomedical Optics
https://www.readbyqxmd.com/read/29051884/curettage-using-soft-wire-for-enchondroma-in-the-hand-a-technical-note
#8
Akio Sakamoto, Shuichi Matsuda
INTRODUCTION: Enchondromas are benign bone cartilaginous lesions predominantly seen in the hand, possibly leading to a pathological fracture. When the lesion expands to the whole phalanx, curettage through a small fenestration is difficult. To overcome the problem, soft-wire (cerclage wire) was used as a curette. Soft-wire is commonly used for a tension band wiring method for patellar or olecranon fractures. TECHNIQUE: Two representative cases are presented: one is a 43-year-old male with enchondroma in the middle phalanx of the left index finger, and the other is a 28-year-old female with enchondroma in the distal phalanx of the right thumb...
May 2017: Journal of Orthopaedic Case Reports
https://www.readbyqxmd.com/read/29051777/melanoma-in-pregnancy
#9
REVIEW
Rebecca Still, Shaun Brennecke
Melanoma is one of the most common cancers diagnosed in pregnancy and has a high metastatic potential. As the incidence of melanoma increases, careful clinical evaluation of suspicious skin lesions remains the mainstay of early diagnosis. There is controversy in the literature as to whether pregnancy-associated melanoma has worse survival than other melanomas. Any changing-pigmented lesion should be biopsied, regardless of pregnancy hyperpigmentation. Increased lymphangiogenesis in pregnancy is associated with increased metastasis - timely diagnosis is therefore imperative...
September 2017: Obstetric Medicine
https://www.readbyqxmd.com/read/29051020/draft-genome-sequences-of-three-multidrug-resistant-cutibacterium-formerly-propionibacterium-acnes-strains-isolated-from-acne-patients-china
#10
Nanxue Zhang, Zhong Lu, Ying Ma
OBJECTIVES: Cutibacterium acnes (formerly Propionibacterium acnes), an anaerobic Gram-positive bacterium, is a skin commensal and considered to be associated with acne. Here we report draft genome sequences of three multidrug-resistant C. acnes strains (CA17, CA39, and CA51), isolated from skin lesions of acne patients from China. METHODS: The whole genome of the three multidrug-resistant C. acnes strains were sequenced using an Illumina HiSeq 2500 platform. De novo assembly and annotation were performed with SPAdes-3...
October 16, 2017: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/29050978/chrysin-attenuates-atopic-dermatitis-by-suppressing-inflammation-of-keratinocytes
#11
Jin Kyeong Choi, Yong Hyun Jang, Soyoung Lee, Sang-Rae Lee, Young-Ae Choi, Meiling Jin, Jung Ho Choi, Jee Hun Park, Pil-Hoon Park, Hyukjae Choi, Taeg Kyu Kwon, Dongwoo Khang, Sang-Hyun Kim
We previously reported the inhibitory effect of chrysin, a natural flavonoid plentifully contained in propolis, vegetables and fruits, on the mast cell-mediated allergic reaction. In this study, we evaluated the effect of chrysin on atopic dermatitis (AD) and defined underlying mechanisms of action. We used an AD model in BALB/c mice by the repeated local exposure of 2,4-dinitrochlorobenzene (DNCB) and house dust mite (Dermatophagoides farinae extract, DFE) to the ears. Repeated alternative treatment of DNCB/DFE caused AD-like skin lesions...
October 16, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29050898/sushi-cervice-and-gnathostomiasis-a-case-report-and-review-of-imported-infections
#12
REVIEW
Jordan Leroy, Marjorie Cornu, Anne Sophie Deleplancque, Séverine Loridant, Emmanuel Dutoit, Boualem Sendid
We describe a case of imported cutaneous gnathostomiasis in a Thai patient living in France. Gnathostomiasis is a zoonosis of food origin. The disease is endemic in Southeast Asia and Latin America. However, over the past 30 years, an increasing number of imported cases has been described in Europe and America. The disease is rare in Western Europe and the majority of cases described had a cutaneous clinical presentation. The disease may sometimes be confused with allergy, leading to a delay in diagnosis. Visceral symptoms are rare but may follow severe attacks...
October 16, 2017: Travel Medicine and Infectious Disease
https://www.readbyqxmd.com/read/29048439/advancing-porphyrin-s-biomedical-utility-via-supramolecular-chemistry
#13
M A Rajora, J W H Lou, G Zheng
Porphyrins are organic heterocyclic macrocycles with photophysical properties well-suited for clinical phototherapy and cancer imaging. However, their wider application in the clinical management of disease is barred by poor aqueous solubility, bioavailability, tumour accumulation and skin phototoxicity. These limitations instigated the development of supramolecular platforms that improved porphyrin pharmacokinetics and tumour-homing. The supramolecular formulation of porphyrins also facilitates single agent-mediated deeper tissue photoactivation, extended imaging and theranostic multimodality, and synergistic application of multiple therapies...
October 19, 2017: Chemical Society Reviews
https://www.readbyqxmd.com/read/29047032/rethinking-skin-lesion-segmentation-in-a-convolutional-classifier
#14
Jack Burdick, Oge Marques, Janet Weinthal, Borko Furht
Melanoma is a fatal form of skin cancer when left undiagnosed. Computer-aided diagnosis systems powered by convolutional neural networks (CNNs) can improve diagnostic accuracy and save lives. CNNs have been successfully used in both skin lesion segmentation and classification. For reasons heretofore unclear, previous works have found image segmentation to be, conflictingly, both detrimental and beneficial to skin lesion classification. We investigate the effect of expanding the segmentation border to include pixels surrounding the target lesion...
October 18, 2017: Journal of Digital Imaging: the Official Journal of the Society for Computer Applications in Radiology
https://www.readbyqxmd.com/read/29046669/susceptibility-to-mycobacterium-ulcerans-disease-buruli-ulcer-is-associated-with-ifng-and-inos-gene-polymorphisms
#15
Stéphanie Bibert, Martin W Bratschi, Samuel Y Aboagye, Emilie Collinet, Nicole Scherr, Dorothy Yeboah-Manu, Christian Beuret, Gerd Pluschke, Pierre-Yves Bochud
Buruli ulcer (BU) is a chronic necrotizing disease of the skin and subcutaneous fat tissue. The causative agent, Mycobacterium ulcerans, produces mycolactone, a macrolide toxin, which causes apoptosis of mammalian cells. Only a small proportion of individuals exposed to M. ulcerans develop clinical disease, as surrounding macrophages may control the infection by bacterial killing at an early stage, while mycolactone concentration is still low. Otherwise, bacterial multiplication leads to in higher concentrations of mycolactone, with formation of necrotizing lesions that are no more accessible to immune cells...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29045624/long-term-cell-culture-isolated-from-lesions-of-mice-infected-with-leishmania-amazonensis-a-new-approach-to-study-mononuclear-phagocyte-subpopulations-during-the-infection
#16
Myriam Janeth Salazar Terreros, Luis Augusto Visani de Luna, Selma Giorgio
Leishmanioses are neglected diseases and the parasite Leishmania survives and proliferates within mononuclear phagocytes, particularly macrophages. In vitro studies of the immunology and cell biology of leishmaniosis are performed in murine peritoneum and bone marrow macrophages and immortalized cell lines despite the normal and injured tissue-specific heterogeneity of macrophages. In this work we established an ex vivo methodology to culture lesional cells from BALB/c mice infected with L. amazonensis. The cells were successfully isolated from footpad skin lesions and those exhibiting macrophage morphology were maintained in long-term culture (12 days), while the small number of lymphocytes, polymorphonuclear and unidentified cells died after one day of culture...
October 14, 2017: Pathogens and Disease
https://www.readbyqxmd.com/read/29045565/cigarette-sidestream-smoke-delays-nucleotide-excision-repair-inhibited-accumulation-of-repair-proteins-at-dna-lesions
#17
Guang Yang, Yuko Ibuki
Cigarette sidestream smoke (CSS) contains many carcinogens that induce DNA damage. DNA damage plays an important role in the initiation of cancer and several diseases, and repair is the major defense mechanism; however, the relationship between CSS and the repair of DNA damage remains unclear. We herein investigated whether CSS influences nucleotide excision repair (NER) in vivo and in vitro. HR-1 hairless mouse skin treated with CSS was exposed to UVB, as a result of which pyrimidine dimers (cyclobutane pyrimidine dimers (CPDs) and pyrimidine(6-4)pyrimidone photoproducts (6-4PPs)) were formed and repaired via the NER pathway...
October 13, 2017: Carcinogenesis
https://www.readbyqxmd.com/read/29045078/skin-tears-and-risk-factors-assessment-a-systematic-review-on-evidence-based-medicine
#18
Raffaele Serra, Nicola Ielapi, Andrea Barbetta, Stefano de Franciscis
Skin tears represent a common condition of traumatic wounds, which may be encountered in some categories of individuals at the extremes of age, such as infants and the elderly. Despite the high prevalence and cost of these lesions, there has been little investigation into the risk factors that lead to this condition. The aim of this review was to systematically evaluate the main risk factors involved in development of skin tears. We planned to include all the studies dealing with risk factors related to skin tears...
October 17, 2017: International Wound Journal
https://www.readbyqxmd.com/read/29044786/unique-profile-of-antimicrobial-peptides-expression-in-polymorphic-light-eruption-lesions-compared-to-healthy-skin-atopic-dermatitis-and-psoriasis
#19
VijayKumar Patra, Gerlinde Mayer, Alexandra Gruber-Wackernagel, Michael Horn, Serena Lembo, Peter Wolf
BACKGROUND: Polymorphic light eruption (PLE) has been attributed to type IV, most likely delayed-type hypersensitivity response (adaptive immunity) but little is known on innate immunity, especially antimicrobial peptides (AMPs) in the disease. Abnormalities in AMP expression have been linked to pathological skin conditions such as atopic dermatitis (AD) and psoriasis. METHODS: AMP profiling was done in PLE skin samples (n,12) compared with that of healthy (n,13), atopic (n,6) and psoriatic skin (n,6)...
October 16, 2017: Photodermatology, Photoimmunology & Photomedicine
https://www.readbyqxmd.com/read/29044628/possible-pro-inflammatory-role-of-heparin-binding-epidermal-growth-factor-like-growth-factor-in-the-active-phase-of-systemic-sclerosis
#20
Megumi Hirabayashi, Yoshihide Asano, Takashi Yamashita, Shunsuke Miura, Kouki Nakamura, Takashi Taniguchi, Ryosuke Saigusa, Takehiro Takahashi, Yohei Ichimura, Takuya Miyagawa, Ayumi Yoshizaki, Tomomitsu Miyagaki, Makoto Sugaya, Shinichi Sato
Heparin-binding epidermal growth factor (EGF)-like growth factor (HB-EGF) is a member of the EGF family growth factors, which affects multiple aspects of the wound healing process such as epithelialization, wound contraction and angiogenesis. In our study, we measured the serum HB-EGF levels of 51 systemic sclerosis (SSc) patients, which showed a significant increase compared with those of 20 normal subjects. Further analysis revealed a positive correlation between the HB-EGF level and pulmonary ground-glass score but no correlation between the former and pulmonary fibrosis score...
October 17, 2017: Journal of Dermatology
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