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https://www.readbyqxmd.com/read/28551824/the-role-of-the-atp2c1-gene-in-hailey-hailey-disease
#1
REVIEW
Hao Deng, Heng Xiao
Hailey-Hailey disease (HHD) is a rare autosomal dominant acantholytic dermatosis, characterized by a chronic course of repeated and exacerbated skin lesions in friction regions. The pathogenic gene of HHD was reported to be the ATPase calcium-transporting type 2C member 1 gene (ATP2C1) located on chromosome 3q21-q24. Its function is to maintain normal intracellular concentrations of Ca(2+)/Mn(2+) by transporting Ca(2+)/Mn(2+) into the Golgi apparatus. ATP2C1 gene mutations are reportedly responsible for abnormal cytosolic Ca(2+)/Mn(2+) levels and the clinical manifestations of HHD...
May 27, 2017: Cellular and Molecular Life Sciences: CMLS
https://www.readbyqxmd.com/read/28551628/regulation-of-mirna-146a-and-mirna-150-levels-by-celecoxib-in-premalignant-lesions-of-k14-hpv16-mice
#2
Rui M Gil DA Costa, Rita Araújo, Joana M O Santos, Mara Fernandes, Tiago Neto, Hugo Sousa, Joana Ribeiro, Margarida M S M Bastos, Paula A Oliveira, Diogo Carmo, Fátima Casaca, Sandra Silva, Carlos Lopes, Rui Medeiros
BACKGROUND/AIM: Human papillomavirus type 16 (HPV16) induces various types of cancer in several locations. Microenvironmental microRNAs (miRNAs) such as miRNA-146a and miRNA-150 regulate cancer-associated inflammation and are involved in HPV-induced carcinogenesis. We studied the effects of celecoxib on the expression of these two miRNAs in HPV16-induced lesions. MATERIALS AND METHODS: Female transgenic (HPV16(+/-)) and wild-type (HPV16(-/-)) mice were administered 75 mg/kg/day celecoxib orally (treatment groups) or placebo (control groups) for four weeks...
June 2017: Anticancer Research
https://www.readbyqxmd.com/read/28551484/a-common-cancer-in-an-uncommon-location-a-case-report-of-squamous-cell-carcinoma-of-the-nipple
#3
Kelly Dye, Melissa Saucedo, Divya Raju, Nail Aydin
INTRODUCTION: Cutaneous squamous cell carcinoma (SCC) is common however SCC is rarely seen on the nipple, with only ten cases of SCC of the nipple in literature (American Cancer Society, 2015; Scotto et al., 1983; Pendse and O'Connor, 2015; Loveland-Jones et al., 2010; Brookes et al., 2005; Sofos et al., 2013; King and Kremer, 2012; Venkataseshan et al., 1994; Hosaka et al., 2011) [1-9]. CASE: An 80 year old female presenting with a chief complaint of an abnormal lesion on the medial portion of her right nipple areola complex...
May 17, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28551069/gene-expression-of-sphingolipid-metabolism-pathways-is-altered-in-hidradenitis-suppurativa
#4
Mohammed Dany, Dirk Elston
BACKGROUND: Hidradenitis suppurativa (HS) is a debilitating skin disease characterized by painful recurrent nodules and abscesses caused by chronic inflammation. Early events in the development of HS are believed to occur in the folliculopilosebaceous unit; however, the signaling pathways behind this mechanism are unknown. Sphingolipids, such as ceramide, are essential components of the skin and appendages and have important structural and signaling roles. OBJECTIVE: We sought to explore whether the gene expression of enzymes involved in sphingolipid metabolic pathways is altered in HS...
May 24, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28550924/new-perspective-on-the-in%C3%A2-vivo-use-of-cold-stress-dynamic-thermography-in-integumental-reconstruction-with-the-use-of-skin-muscle-flaps
#5
Szymon Kolacz, Mateusz Moderhak, Jerzy Jankau
BACKGROUND: Among the problems encountered by plastic surgeons is the reconstruction of defects following tumors. One of the reconstructive options is trans rectus abdominis (TRAM) flap. Despite that anatomy is well explored, marginal flap necrosis may develop. To minimize the complications, imaging examinations were designed to determine the degree of flap perfusion. One of them is the thermographic examination. MATERIALS AND METHODS: We examined 38 patients who had undergone 10 reconstructive breast surgeries with a pedicled TRAM ipsilateral flap, 10 patients with a TRAM contralateral flap, and 18 patients with a TRAM supercharged flap...
May 15, 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/28550824/-analysis-of-the-cochrane-review-topical-treatments-for-scalp-psoriasis-cochrane-database-syst-rev-2016-2-cd009687
#6
Catarina Soares Queirós, Gonçalo Silva Duarte, João Costa, António Vaz-Carneiro
Regardless the psoriasis subtype, up to 79% of people with this skin condition present scalp involvement, which is often the first site to show symptoms of the disease. In addition to being itchy, the red and scaly lesions are usually easy to see, and may be embarrassing. Topical therapy is usually the first line of treatment; however the wide array of available interventions can make the choice difficult, and may even lead to an inadequate treatment. The objective of this review was to evaluate the efficacy and safety of topical treatments for scalp psoriasis...
March 31, 2017: Acta Médica Portuguesa
https://www.readbyqxmd.com/read/28550787/apocrine-sweat-gland-adenocarcinoma-a-rare-case-report-and-review
#7
Arthur Paredes Gatti, Luiza Tonello, William Pfaffenzeller, Fernando Oliveira Savóia, Diego Inácio Goergen, Rodrigo De Pieri Coan, Uirá Fernandes Teixeira, Fábio Luiz Waechter, Paulo Roberto Ott Fontes
INTRODUCTION: Primary apocrine sweat gland carcinoma (PASGC) is an extremely rare neoplasia whose management and treatment are still evolving. The only curative therapy is wide local excision. Many patients have metastasis at the time of the diagnosis, mainly because this neoplasm has been misdiagnosed as some benign skin lesions. PRESENTATION OF CASE: We herein report a case of a 72-year-old-man with PASGC affecting the axilla and regional lymph nodes that underwent surgical resection and lymphadenectomy at our Institution...
May 18, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28549611/successful-short-desensitization-treatment-protocol-with-narrowband-uvb-phototherapy-tl-01-in-polymorphic-light-eruption
#8
A Combalia, C Fernández-Sartorio, X Fustà, D Morgado-Carrasco, S Podlipnik, P Aguilera
INTRODUCTION: Polymorphic light eruption (PLE) is a common idiopathic photodermatosis that typically presents with pruritic papular or papulovesicular lesions on sun-exposed skin between spring and autumn. In many subjects PLE is mild, and can usually be prevented by the use of broad-spectrum topical sunscreens and a gradual increase in sunlight exposure. However, in some individuals, sunlight exposure results in florid PLE and they often benefit from prophylactic desensitization treatment using phototherapy in early spring, an artificial method that induces a "hardening" phenomenon...
May 23, 2017: Actas Dermo-sifiliográficas
https://www.readbyqxmd.com/read/28548465/assessment-of-infantile-hemangiomas-using-a-handheld-wireless-diffuse-optical-spectroscopic-device
#9
Christopher J Fong, Maria C Garzon, Jennifer W Hoi, Hyun K Kim, Christine T Lauren, Kimberly Morel, Lauren Geller, Nina Antonov, Nicole Weitz, June Wu, Andreas H Hielscher
BACKGROUND/OBJECTIVES: Infantile hemangiomas (IHs) are vascular tumors with the potential for significant morbidity. There is a lack of validated objective tools to assess IH severity and response to treatment. Diffuse optical spectroscopy (DOS), a noninvasive, nonionizing imaging modality, can measure total hemoglobin concentration and hemoglobin oxygen saturation in tissue to assess IH vascularity and response to treatment. Our objective was to evaluate the utility of a wireless, handheld DOS system to assess IH characteristics at selected points during their clinical course...
May 26, 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/28548244/primary-histiocytic-sarcoma-presenting-as-diffuse-leptomeningeal-disease-case-description-and-review-of-the-literature
#10
Magda Zanelli, Moira Ragazzi, Giovanni Marchetti, Alessandra Bisagni, Massimo Principi, Daniela Fanni, Elisabetta Froio, Silvia Serra, Eleonora Zanetti, Loredana De Marco, Felice Giangaspero, Stefano Ascani
Histiocytic sarcoma is a rare malignant neoplasm arising most commonly in lymph nodes, intestinal tract, skin and soft tissue. The incidence of primary CNS histiocytic sarcoma is even rarer with a total of just 27 cases reported in the literature so far. Herein we describe the first autopsy case of histiocytic sarcoma presenting as a diffuse leptomeningeal disease in absence of a CNS tumor-forming parenchymal lesion. The clinical, pathological and immunophenotypic features are described and an updated literature review on primary CNS histiocytic sarcoma is included...
May 26, 2017: Neuropathology: Official Journal of the Japanese Society of Neuropathology
https://www.readbyqxmd.com/read/28547523/cutaneous-manifestations-of-medium-and-large-vessel-vasculitis
#11
REVIEW
Francois Chasset, Camille Francès
Dermatologic manifestations are observed in almost all systemic vasculitides, even in large-and medium-vessel vasculitides, although such vessels are not found in the skin. Cutaneous manifestations may be related to a direct skin localization of the systemic vasculitis or a non-specific process associated with the vasculitis. According to the 2012 International Chapel Hill consensus, the two major variants of large-vessel vasculitides are Takayasu arteritis and giant-cell arteritis. In Europe and North America, acute inflammatory nodules or erythema nodosum-like lesions are the most commonly observed skin lesions with Takayasu arteritis...
May 26, 2017: Clinical Reviews in Allergy & Immunology
https://www.readbyqxmd.com/read/28547342/trichosporon-asteroides-isolated-from-cutaneous-lesions-of-a-suspected-case-of-paracoccidioidomycosis-ceti-in-a-bottlenose-dolphin-tursiops-truncatus
#12
Keiichi Ueda, Ichiro Nakamura, Eiko Nakagawa Itano, Kazunori Takemura, Yasutomo Nakazato, Ayako Sano
"Paracoccidioidomycosis ceti" is a rare zoonotic fungal infection affecting dolphins and is endemic worldwide. The causative agents are Paracoccidioides species; however, it is impossible to isolate the fungal species. We isolated Trichosporon asteroides from multifocal, irregularly raised skin lesions on a female bottlenose dolphin (Tursiops truncatus) captured off coast of Japan, which was suspected to have "paracoccidioidomycosis ceti." An abundance of round, yeast-like cells was detected in a potassium hydroxide direct-mount specimen of the skin samples; however, nested PCR targeting the partial sequence of 43-kDa glycoprotein-coding gene correspondent to Paracoccidioides sp...
May 25, 2017: Mycopathologia
https://www.readbyqxmd.com/read/28546473/complete-genome-sequence-of-staphylococcus-aureus-bacteriophage-psa-3
#13
Sang Guen Kim, Jin Woo Jun, Sib Sankar Giri, Saekil Yun, Hyoun Joong Kim, Cheng Chi, Sang Wha Kim, Se Chang Park
Staphylococcus aureus phage pSa-3, isolated in South Korea from a sewage sample, has a 137-kb genome with 29% G+C content. This phage was targeted to control the bacteria in clinical isolates (mainly from skin lesions) and can be used in the decolonization of S. aureus.
May 25, 2017: Genome Announcements
https://www.readbyqxmd.com/read/28544808/the-first-transepidermal-transplantation-of-non-cultured-epidermal-suspension-using-a-dermarolling-system-in-vitiligo-a-sequential-histological-and-clinical-study
#14
L Benzekri, Y Gauthier
The current methods for melanocyte delivery to depigmented skin are invasive and often require sophisticated approaches. Here we describe a promising simple and minimally invasive technique based on the dermarolling system. The technique involves preparation of a keratinocyte/melanocyte suspension prepared by trypsinization from a non-lesioned part of a patient's scalp skin and transepidermal delivery using a dermaroller equipped with 0.2 mm needles. Dermarolling leads to epidermal microinjuries without, however, causing pain or inflammation...
May 19, 2017: Pigment Cell & Melanoma Research
https://www.readbyqxmd.com/read/28544089/benign-atrophic-papulosis-k%C3%A3-hlmeier-degos-disease-the-wedge-shaped-dermal-necrosis-can-resolve-with-time
#15
Christos C Zouboulis, Athanasios Theodoridis, Martina Brunner, Cynthia M Magro
BACKGROUND: Atrophic papulosis is a rare thrombo-occlusive disease, characterized by the appearance of multiple atrophic porcelain-white skin papules, with a surrounding erythematous rim, which are histologically consisting of wedge-shaped necrosis of the dermis. OBJECTIVE: It consists of two variants: a) the benign atrophic papulosis (BAP) only involving the skin and b) the malignant atrophic papulosis (MAP) also involving several internal organs with a cumulative 5-year survival rate of approx...
May 23, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28543966/development-of-a-quantitative-assessment-method-of-pigmentary-skin-disease-using-ultraviolet-optical-imaging
#16
Onseok Lee, Sunup Park, Jaeyoung Kim, Chilhwan Oh
BACKGROUND/PURPOSE: The visual scoring method has been used as a subjective evaluation of pigmentary skin disorders. Severity of pigmentary skin disease, especially melasma, is evaluated using a visual scoring method, the MASI (melasma area severity index). This study differentiates between epidermal and dermal pigmented disease. The study was undertaken to determine methods to quantitatively measure the severity of pigmentary skin disorders under ultraviolet illumination. METHODS: The optical imaging system consists of illumination (white LED, UV-A lamp) and image acquisition (DSLR camera, air cooling CMOS CCD camera)...
May 21, 2017: Skin Research and Technology
https://www.readbyqxmd.com/read/28543887/treatment-of-venous-lake-with-multi-wavelength-595-and-1064-nm-lasers-in-asian-fitzpatrick-skin-type-iv-patients
#17
Jing Yang, Xiaohong Guo, Xiaorong Tong, Juan Tao
BACKGROUND: Multi-wavelength lasers are reportedly useful for treating venous lake (VL) in Caucasian patients. However, the same parameters may not be safe for Asian patients with Fitzpatrick skin type (FST) IV. PURPOSE: Report experience with using multi-wavelength laser for VL treatment in Asian patients with FST IV. METHODS: Seventeen episodes of VL in 15 Chinese patients with FST IV were treated. 595-nm pulsed dye (PDL) laser followed by 1,064-nm neodymium-doped yttrium aluminum garnet (Nd:YAG) laser were administered...
May 24, 2017: Photodermatology, Photoimmunology & Photomedicine
https://www.readbyqxmd.com/read/28543730/treatment-of-disseminated-superficial-actinic-porokeratosis-with-oral-alitretinoin
#18
B J Park, E H Oh, J E Kim, J Y Ko, Y S Ro
Disseminated superficial actinic porokeratosis (DSAP), the most common type of porokeratosis, usually presents as large numbers of lesions on sun-exposed skin. Although several treatment options including corticosteroids, keratolytics, 5-fluorouracil, imiquimod, vitamin D3 analogues, cryotherapy, curettage, laser therapy and dermabrasion may be considered, there is no evidence-based standard treatment.(1-2) Patient 1 was a 26-year-old female who presented with a 2-year history of progressive scaly macules on both upper and lower extremities...
May 22, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28543665/immunohistochemical-evaluation-of-epidermal-proliferation-differentiation-and-melanocytic-density-in-symmetrical-acrokeratoderma
#19
P-P Yang, J Peng, Y-Y Wu, Z Liu, P Sheng, Y Zhou, S-J Li, Y-M Fan
BACKGROUND: Symmetrical acrokeratoderma (SAK) is characterized by brown to black hyperkeratotic patches on acral regions. Although epidermal hyperkeratosis and acanthosis are consistent pathological changes, the nature of epidermal hyperplasia is unknown. AIM: To evaluate epidermal proliferation and differentiation and melanocytic density in skin lesions of SAK. METHODS: Expression of keratin 10 (K10), K14, K16, involucrin, filaggrin, Ki-67, and Melan-A was detected by immunohistochemistry in eight patients with SAK, seven patients with ichthyosis vulgaris (IV) and six healthy controls (HCs)...
May 22, 2017: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/28543605/eosinophilic-annular-erythema-is-clinically-characterized-by-central-pigmentation-reflecting-basal-melanosis-a-clinicopathological-study-of-10-cases
#20
Shinichi Nakazato, Yasuyuki Fujita, Satoru Shinkuma, Toshifumi Nomura, Hiroshi Shimizu
BACKGROUND: Eosinophilic annular erythema (EAE) has been proposed as a clinical entity to describe annular skin lesions associated with tissue eosinophilia. However, systematic investigations on the histopathology of EAE have not been performed, and useful histopathological findings for diagnosis of EAE remain unknown. OBJECTIVE: The aim of this study was to investigate the clinicopathological features of EAE METHODS: We retrospectively studied 10 patients at our hospital during a 5-year span who clinically showed annular or figurate lesions and histopathologically exhibited eosinophilic infiltration in the dermis...
May 22, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
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