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https://www.readbyqxmd.com/read/29925003/energy-metabolism-rewiring-precedes-uvb-induced-primary-skin-tumor-formation
#1
Mohsen Hosseini, Léa Dousset, Walid Mahfouf, Martin Serrano-Sanchez, Isabelle Redonnet-Vernhet, Samir Mesli, Zeinab Kasraian, Emilie Obre, Marc Bonneu, Stephane Claverol, Marija Vlaski, Zoran Ivanovic, Walid Rachidi, Thierry Douki, Alain Taieb, Anne-Karine Bouzier-Sore, Rodrigue Rossignol, Hamid Reza Rezvani
Although growing evidence indicates that bioenergetic metabolism plays an important role in the progression of tumorigenesis, little information is available on the contribution of reprogramming of energy metabolism in cancer initiation. By applying a quantitative proteomic approach and targeted metabolomics, we find that specific metabolic modifications precede primary skin tumor formation. Using a multistage model of ultraviolet B (UVB) radiation-induced skin cancer, we show that glycolysis, tricarboxylic acid (TCA) cycle, and fatty acid β-oxidation are decreased at a very early stage of photocarcinogenesis, while the distal part of the electron transport chain (ETC) is upregulated...
June 19, 2018: Cell Reports
https://www.readbyqxmd.com/read/29924416/autoantibody-profile-and-clinical-patterns-in-619-italian-patients-with-cutaneous-lupus-erythematosus
#2
A Verdelli, A Coi, A V Marzano, E Antiga, E Cozzani, P Quaglino, M La Placa, M Benucci, C De Simone, M Papini, A Parodi, F Bianchi, M Caproni
BACKGROUND: Anti-nuclear antibodies (ANA), anti-extractable nuclear antigens (ENA) and anti-dsDNA antibodies are often associated with cutaneous lupus erythematosus (CLE), with variable frequency depending on skin subtype. However, specific data based on large case-series on the pathogenetic, diagnostic, and prognostic meaning of such autoantibodies are still lacking. OBJECTIVE: To characterize the correlations between CLE subtypes as well as LE-non specific skin lesions and their autoantibody pattern...
June 20, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29924358/blastomycosis-in-southern-saskatchewan-2000-2015-unique-presentations-and-disease-characteristics
#3
Sarah Lohrenz, Jessica Minion, Mamata Pandey, Kumudhini Karunakaran
In the literature, cases of blastomycosis in Canada have been documented in provinces bordering the Great Lakes, including Ontario and Quebec, as well as Manitoba. This is the first study to our knowledge reporting cases of mycosis seen in southern Saskatchewan suggesting a broader area of endemicity. We searched the Regina Qu'Appelle Health Region (RQHR) Microbiology Laboratory for all culture-confirmed cases of Blastomyces from January 2000 to December 2015 and identified 15 cases. Thirteen cases were reviewed, identifying common presenting symptoms, misdiagnosis, comorbidities, travel history, time from presentation to diagnosis, diagnostic specimen, treatment, and clinical outcome...
June 19, 2018: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
https://www.readbyqxmd.com/read/29924253/density-of-mast-cells-and-intensity-of-pruritus-in-psoriasis-vulgaris-a-cross-sectional-study
#4
Letícia Pargendler Peres, Fabiana Bazanella Oliveira, André Cartell, Nicolle Gollo Mazzotti, Tania Ferreira Cestari
BACKGROUND: Psoriasis is a chronic and prevalent disease, and the associated pruritus is a common, difficult-to-control symptom. The mediators involved in psoriatic pruritus have not been fully established. OBJECTIVE: To evaluate associations between the number of mast cells in psoriatic lesions and the intensity of pruritus. METHODS: 29 patients with plaque psoriasis were recruited. In all participants, Psoriasis Area and Severity Index and Body Surface Area were assessed...
June 2018: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/29924240/clinical-trial-for-uniform-multidrug-therapy-for-leprosy-patients-in-brazil-u-mdt-ct-br-adverse-effects-approach
#5
Rossilene Conceição da Silva Cruz, Samira Bührer-Sékula, Gerson Oliveira Penna, Maria Elisabete Amaral de Moraes, Heitor de Sá Gonçalves, Mariane Martins de Araújo Stefani, Maria Lúcia Fernandes Penna, Maria Araci de Andrade Pontes, Sinésio Talhari
BACKGROUND: The Clinical Trial for Uniform Multidrug Therapy for Leprosy Patients in Brazil (U-MDT/CT-BR), designed to evaluate the effectiveness of a six-months regimen, assessed the adverse effects caused by the drugs. OBJECTIVE: Describe adverse effects due to MDT in U-MDT/CT-BR, comparing the uniform regimen (U-MDT) to the current WHO regimen (R-MDT). PATIENTS AND METHODS: After operational classification, patients were randomly allocated to the study groups...
June 2018: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/29924021/mammographic-and-ultrasound-findings-in-poroid-hidradenoma-of-the-breast-mimicking-intraductal-papilloma-and-papillary-carcinoma-a-case-report
#6
Bo Hwa Choi, Mi Young Kim, So Dug Lim, Jung-Hyun Yang, Ji Young Ha, Nami Choi
RATIONALE: Poroid hidradenoma (PH) is a rare variant of benign sweat gland neoplasm without connection to the epidermis. This tumor presents clinically as a solitary lesion with a cystic component located in the subcutaneous layer abutting the skin. On ultrasound, it appears as a circumscribed complex cystic and solid mass abutting the dermis. The occurrence of PH in the breast is very rare. Its features overlap with intraductal papilloma and papillary carcinoma. PATIENT CONCERNS: A 66-year-old woman presented with a palpable lump in her right breast...
June 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29924015/cutaneous-mucormycosis-caused-by-rhizopus-microsporus-in-an-immunocompetent-patient-a-case-report-and-review-of-literature
#7
Yilun Wang, Min Zhu, Yunqi Bao, Li Li, Liping Zhu, Feng Li, Jinhua Xu, Jun Liang
RATIONALE: Cutaneous mucormycosis is an uncommon disease and occurs rarely in immunocompetent patients. PATIENT CONCERNS: We reported the case of a 37-year-old man presenting with a skin lesion on the left side of the chest wall with no history of trauma or primary diseases. He was firstly misdiagnosed as tuberculosis and the proper treatment was thus delayed. DIAGNOSES: Histopathological examination and fungal culture of the lesion confirmed cutaneous mucormycosis...
June 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29923228/the-self-assessed-psychological-comorbidities-of-prurigo-in-european-patients-a-multi-centre-study-in-13-countries
#8
Emilie Brenaut, Jon Anders Halvorsen, Florence J Dalgard, Lars Lien, Flora Balieva, Francesca Sampogna, Dennis Linder, Andrea W M Evers, Gregor B E Jemec, Uwe Gieler, Jacek Szepietowski, Françoise Poot, Ilknur K Altunay, Andrew Y Finlay, Sam S Salek, Csanad Szabo, Andrey Lvov, Servando E Marron, Lucia Tomas-Aragones, Jörg Kupfer, Laurent Misery
BACKGROUND: Prurigo is defined by the presence of chronic pruritus and multiple localized or generalized pruriginous lesions. OBJECTIVE: The aim of this study was to assess the psychological burden of prurigo in patients of European countries. METHODS: In this multicentre European study, 3635 general dermatology outpatients and 1359 controls were included. Socio-demographic data and answers to questionnaires (regarding quality of life, general health, anxiety and depression and suicidal ideation) were collected...
June 19, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29923189/the-new-8th-edition-of-tnm-staging-and-its-implications-for-skin-cancer-a-review-by-the-british-association-of-dermatologists-and-the-royal-college-of-pathologists-united-kingdom
#9
REVIEW
S G Keohane, C M Proby, C Newlands, R J Motley, I Nasr, M F Mohd Mustapa, D N Slater
The 8th edition of TNM (Tumour, Node and Metastasis) has numerous and important changes compared to the 7th edition. Public Health England (PHE) and the Royal College of Pathologists, United Kingdom (RCPath) have adopted the 8th edition of TNM (TNM8) published by the Union for International Cancer Control (UICC) for skin cancer staging. These changes will have an impact on the management of both non-melanoma and melanoma skin cancer by all members of the skin cancer multidisciplinary team. These will also need to be highlighted to commissioners and managers for appropriate service planning...
June 19, 2018: British Journal of Dermatology
https://www.readbyqxmd.com/read/29922466/hidradenitis-suppurativa-with-sapho-syndrome-maintained-effectively-with-adalimumab-methotrexate-and-intralesional-corticosteroid-injections
#10
Erika L Crowley, Ashley O'Toole, Melinda J Gooderham
Introduction: Hidradenitis suppurativa and synovitis, acne, pustulosis, hyperostosis, osteitis syndrome are chronic, debilitating diseases involving apocrine gland-bearing skin inflammation and bone inflammation, respectively. Although both often present with multiple comorbidities, single patient co-presentation is rare. Methods/Results: This study reports the 8-year treatment course of a 40-year-old man with hidradenitis suppurativa and synovitis, acne, pustulosis, hyperostosis, osteitis syndrome, and reviews relevant literature...
2018: SAGE Open Medical Case Reports
https://www.readbyqxmd.com/read/29922288/translating-observations-from-leishmanization-into-non-living-vaccines-the-potential-of-dendritic-cell-based-vaccination-strategies-against-leishmania
#11
REVIEW
Negar Seyed, Nathan C Peters, Sima Rafati
Leishmaniasis is a health-threatening vector-borne disease in almost 90 different countries. While a prophylactic human vaccine is not yet available, the fact that recovery from leishmaniasis establishes lifelong immunity against secondary infection suggests that a vaccine is attainable. In the past, deliberate infection with virulent parasites, termed Leishmanization, was used as a live-vaccine against cutaneous leishmaniasis and effectively protected against vector-transmitted disease in endemic areas. However, the practice was discontinued due to major complications including non-healing skin lesions, exacerbation of skin diseases, and the potential impact of immunosuppression...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29921365/idiopathic-dermal-necrosis-in-black-tailed-prairie-dogs-cynomys-ludovicianus
#12
Brandi M Heckel, David Eshar, Kelli M Almes
Because black-tailed prairie dogs (Cynomys ludovicianus) are used as a model for research on gallstones and bacterial infections, performing urinary evaluations can provide invaluable data. This case report involves 5 prairie dogs that developed moist necrotic skin lesions after urine collection by cystocentesis. The information presented here serves as a resource regarding a potential adverse event that may develop after cystocentesis in black-tailed prairie dogs.
June 1, 2018: Comparative Medicine
https://www.readbyqxmd.com/read/29921290/causes-of-mortality-and-morbidity-in-free-ranging-mustelids-in-switzerland-necropsy-data-from-over-50-years-of-general-health-surveillance
#13
E Akdesir, F C Origgi, J Wimmershoff, J Frey, C F Frey, M-P Ryser-Degiorgis
BACKGROUND: Although mustelids occur worldwide and include a wide range of species, little is known about the diseases affecting them. Mustelids have regularly been submitted for post mortem investigation in the framework of the program for general wildlife health surveillance in Switzerland, which has been in place for nearly 60 years. We performed a retrospective analysis of the necropsy reports on mustelids submitted to the diagnostic service of the University of Bern. The aims of this study were to present an overview of the causes of mortality and morbidity observed in these carnivores, to assess differences among species, to assess changes in disease detection over the study period, and to describe the pathology of selected diseases...
June 19, 2018: BMC Veterinary Research
https://www.readbyqxmd.com/read/29921238/jaundice-caused-by-protrusion-of-a-hepatic-cyst-into-common-bile-duct-that-was-resolved-by-choledochoscopic-needle-knife-electrotomy-a-case-report
#14
Cheng Zhang, Yue-Feng Ma, Yu-Long Yang
BACKGROUD: Hepatic cysts are the most frequent, innocuous, space-occupying lesions of the liver. The majority of solitary liver cysts are nonsymptomatic. When liver cysts reach a large size, there are some complications, including infection, rupture, spontaneous hemorrhage, obstructive jaundice, and neoplastic degeneration. Percutaneous aspiration, fenestration, hepatic resection, and liver transplantation have been proposed for symptomatic patients. CASE PRESENTATION: In this case report, we describe a 41-year-old woman who presented with persistent liver dysfunction, indolent xanthochromia, and skin itching for 3 months...
June 19, 2018: BMC Gastroenterology
https://www.readbyqxmd.com/read/29921078/-surgical-treatment-of-external-auricular-cholesteatoma-involving-tympanum-and-papilloma
#15
Z Y Song, X M Yu, C F Wang, N Wang, Y Fu, Y Q Song
Objective: To explore the operation treatments and their outcomes of external auditory canal cholesteatomas involving the tympanic cavity and mastoid process. Method: Forty-two patients (45 ears) with external auditory canal cholesteatomas were included in this study who were operated. All lesions invaded the tympanic cavity and mastoid process. Excision of cholesteatoma, external auditory canal angioplasty and concha formation were performed. Ossicular chain reconstruction was performed in 3 ears. Mastoidectomy with close technique were performed in 4 ears...
June 2018: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
https://www.readbyqxmd.com/read/29921037/hydrogen-gas-inhalation-protects-against-cutaneous-ischaemia-reperfusion-injury-in-a-mouse-model-of-pressure-ulcer
#16
Wei Fang, Guizhen Wang, Luyan Tang, Huilin Su, Huyan Chen, Wanqing Liao, Jinhua Xu
Pressure ulcer formation depends on various factors among which repetitive ischaemia/reperfusion(I/R) injury plays a vital role. Molecular hydrogen (H2 ) was reported to have protective effects on I/R injuries of various internal organs. In this study, we investigated the effects of H2 inhalation on pressure ulcer and the underlying mechanisms. H2 inhalation significantly reduced wound area, 8-oxo-dG level (oxidative DNA damage) and cell apoptosis rates in skin lesions. H2 remarkably decreased ROS accumulation and enhanced antioxidant enzymes activities by up-regulating expression of Nrf2 and its downstream components in wound tissue and/or H2 O2 -treated endothelia...
June 19, 2018: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/29920828/cannabinoid-receptor-types-1-and-2-and-peroxisome-proliferator-activated-receptor-%C3%AE-distribution-in-the-skin-of-clinically-healthy-cats-and-cats-with-hypersensitivity-dermatitis
#17
Vincenzo Miragliotta, Pier Luca Ricci, Francesco Albanese, Andrea Pirone, Danika Tognotti, Francesca Abramo
BACKGROUND: Cannabinoid receptors and peroxisome proliferator-activated receptor-alpha (PPAR-α) are gaining recognition as potential therapeutic targets for the treatment of skin disorders. HYPOTHESIS/OBJECTIVES: The aim of this study was to investigate the distribution of cannabinoid type 1 and 2 receptors (CBR1 and CBR2) and PPAR-α in feline skin and verify whether changes occur in the course of hypersensitivity dermatitis. ANIMALS: Twelve privately owned cats...
June 19, 2018: Veterinary Dermatology
https://www.readbyqxmd.com/read/29920789/physician-patient-communication-and-patient-reported-outcomes-in-the-actinic-keratosis-treatment-adherence-initiative-ak-train-a-multicenter-prospective-real-life-study-of-treatment-satisfaction-quality-of-life-and-adherence-to-topical-field-directed-therapy
#18
Luca Neri, Ketty Peris, Caterina Longo, Stefano Calvieri, Pasquale Frascione, Aurora Parodi, Eibenschuz Laura, Ugo Bottoni, Giovanni Pellacani
BACKGROUND: Patients with multiple actinic keratoses (AK) should be treated with field-directed therapy. Such treatments challenge patients' adherence due out-of-pocket costs, length of treatment and severity of Local Skin Reactions (LSRs). Effective physician-patient communication (PPC) may buffer therapy-related distress thus improving quality of life, treatment satisfaction and adherence. OBJECTIVES: We evaluated the interplay between PPC, LSR intensity (safety) and lesion clearance rates (effectiveness) on treatment satisfaction, quality of life and treatment adherence among patients with multiple AK receiving topical field-directed therapies...
June 19, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29920317/alternative-uses-of-dermatoscopy-in-daily-clinical-practice-an-update
#19
REVIEW
Giuseppe Micali, Anna Elisa Verzì, Francesco Lacarrubba
Dermatoscopy is a non-invasive diagnostic tool currently used for neoplastic skin lesions, several inflammatory and infectious diseases, and skin appendage disorders. As the clinical applications of dermatoscopy beyond pigmented lesions are constantly increasing, the aim of this paper is to provide an update on this topic. This comprehensive review substantiates how several diseases may show peculiar dermatoscopy features so to enhance the diagnosis and to avoid in selected cases unnecessary histological confirmation...
June 16, 2018: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29920140/the-utility-of-muscle-sparing-axillar-skin-crease-incision-with-thoracoscopic-surgery-in-children
#20
Ryota Souzaki, Naonori Kawakubo, Kina Miyoshi, Satoshi Obata, Yoshiaki Kinoshita, Junkichi Takemoto, Kenichi Kohashi, Yoshinao Oda, Tomoaki Taguchi
BACKGROUND: Thoracoscopic surgery for pediatric benign tumors is a common procedure. However, a large incision is needed to remove large tumors from the thoracic cavity. And, for intrapulmonary sequestration in lower lobe, it sometimes needs a large incision to ligate the aberrant vessels. A muscle-sparing axillar skin crease incision (MSASCI) has been introduced for thoracic open surgery, resulting in excellent aesthetic outcomes compared with a standard incision. We herein report the utility of this MSASCI technique in thoracoscopic surgery to remove large tumors from the thoracic cavity and to ligate the aberrant vessels in intrapulmonary sequestration in lower lobe...
June 19, 2018: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
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