keyword
https://read.qxmd.com/read/38532289/synaptic-vesicle-glycoprotein-2c-enhances-vesicular-storage-of-dopamine-and-counters-dopaminergic-toxicity
#1
JOURNAL ARTICLE
Meghan L Bucher, Amy R Dunn, Joshua M Bradner, Kristen Stout Egerton, James P Burkett, Michelle A Johnson, Gary W Miller
Dopaminergic neurons of the substantia nigra exist in a persistent state of vulnerability resulting from high baseline oxidative stress, high-energy demand, and broad unmyelinated axonal arborisations. Impairments in the storage of dopamine compound this stress because of cytosolic reactions that transform the vital neurotransmitter into an endogenous neurotoxicant, and this toxicity is thought to contribute to the dopamine neuron degeneration that occurs Parkinson's disease. We have previously identified synaptic vesicle glycoprotein 2C (SV2C) as a modifier of vesicular dopamine function, demonstrating that genetic ablation of SV2C in mice results in decreased dopamine content and evoked dopamine release in the striatum...
March 26, 2024: European Journal of Neuroscience
https://read.qxmd.com/read/38518965/si-wu-tang-attenuates-hepatocyte-panoptosis-and-m1-polarization-of-macrophages-in-non-alcoholic-fatty-liver-disease-by-influencing-the-intercellular-transfer-of-mtdna
#2
JOURNAL ARTICLE
Zhi Ma, Kaihong Xie, Xiaoyong Xue, Jianan Li, Yang Yang, Jianzhi Wu, Yufei Li, Xiaojiaoyang Li
ETHNOPHARMACOLOGICAL RELEVANCE: Non-alcoholic fatty liver disease (NAFLD) represents a burgeoning challenge for public health with potential progression to malignant liver diseases. PANoptosis, an avant-garde conceptualization of cell deaths, is closely associated with mitochondrial damage and linked to multiple liver disorders. Si-Wu-Tang (SWT), a traditional Chinese herbal prescription renowned for regulating blood-related disorders and ameliorating gynecological and hepatic diseases, has been demonstrated to alleviate liver fibrosis by regulating bile acid metabolism and immune responses...
March 20, 2024: Journal of Ethnopharmacology
https://read.qxmd.com/read/38514795/mcu-independent-ca-2-uptake-mediates-mitochondrial-ca-2-overload-and-necrotic-cell-death-in-a-mouse-model-of-duchenne-muscular-dystrophy
#3
JOURNAL ARTICLE
Michael J Bround, Eaman Abay, Jiuzhou Huo, Julian R Havens, Allen J York, Donald M Bers, Jeffery D Molkentin
Mitochondrial Ca2+ overload can mediate mitochondria-dependent cell death, a major contributor to several human diseases. Indeed, Duchenne muscular dystrophy (MD) is driven by dysfunctional Ca2+ influx across the sarcolemma that causes mitochondrial Ca2+ overload, organelle rupture, and muscle necrosis. The mitochondrial Ca2+ uniporter (MCU) complex is the primary characterized mechanism for acute mitochondrial Ca2+ uptake. One strategy for preventing mitochondrial Ca2+ overload is deletion of the Mcu gene, the pore forming subunit of the MCU-complex...
March 21, 2024: Scientific Reports
https://read.qxmd.com/read/38514185/structural-plasticity-of-gabaergic-pallidothalamic-terminals-in-mptp-treated-parkinsonian-monkeys-a-3d-electron-microscopic-analysis
#4
JOURNAL ARTICLE
G J Masilamoni, H Kelly, A J Swain, J F Pare, R M Villalba, Y Smith
The internal globus pallidus (GPi) is a major source of tonic GABAergic inhibition to the motor thalamus. In parkinsonism, the firing rate of GPi neurons is increased, and their pattern switches from a tonic to a burst mode, two pathophysiological changes associated with increased GABAergic pallidothalamic activity. In this study, we used high-resolution 3D electron microscopy to demonstrate that GPi terminals in the parvocellular ventral anterior nucleus (VApc) and the centromedian nucleus (CM), the two main GPi-recipient motor thalamic nuclei in monkeys, undergo significant morphometric changes in parkinsonian monkeys including (1) increased terminal volume in both nuclei; (2) increased surface area of synapses in both nuclei; (3) increased number of synapses/GPi terminals in the CM, but not VApc; and (4) increased total volume, but not number, of mitochondria/terminals in both nuclei...
March 2024: ENeuro
https://read.qxmd.com/read/38511277/emodin-blocks-mptp-opening-and-improves-lps-induced-hmec-1cell-injury-by-upregulation-of-atp5a1
#5
JOURNAL ARTICLE
Tietao Di, Limin He, Qing Shi, Lu Chen, Lei Zhu, Sisi Zhao, Chunling Zhang
BACKGROUND: Emodin has been shown to exert anti-inflammatory and cytoprotective effects. Our study aimed to identify a novel anti-inflammatory mechanism of emodin. METHODS: An LPS-induced model of microvascular endothelial cell (HMEC-1) injury was constructed. Cell proliferation was examined using a CCK-8 assay. The effects of emodin on reactive oxygen species (ROS), cell migration, the mitochondrial membrane potential (MMP), and the opening of the mitochondrial permeability transition pore (mPTP) were evaluated...
March 21, 2024: Chemistry & Biodiversity
https://read.qxmd.com/read/38501412/-resveratrol-protects-dopaminergic-neurons-in-a-mouse-model-of-parkinson-s-disease-by-regulating-the-gut-brain-axis-via-inhibiting-the-tlr4-signaling-pathway
#6
JOURNAL ARTICLE
J Gui, X Sun, S Wen, X Liu, B Qin, M Sang
OBJECTIVE: To investigate the protective effect of resveratrol on intestinal barrier in 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP)-induced Parkinson's disease (PD) mouse models and its mechanism for regulating TLR4/MyD88/NF-κB signaling to protect dopaminergic neurons. METHODS: Fifty-two C57BL/6J mice were randomized into control group ( n = 12), MPTP group ( n =14), MPTP + resveratrol (30 mg/kg) group ( n =13), and MPTP + resveratrol (90 mg/kg) group ( n =13), and mouse models were established by intraperitoneal MPTP (30 mg/kg) injection for 7 days in the latter 3 groups...
February 20, 2024: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://read.qxmd.com/read/38500318/effects-of-electroacupuncture-on-mitophagy-mediated-by-sirt3-pink1-parkin-pathway-in-parkinson-s-disease-mice
#7
JOURNAL ARTICLE
Gui-Jun Zhang, Yao Wang, Jun-Ling Li, Jun Ma, Yan-Chun Wang
OBJECTIVES: To observe the effects of electroacupuncture (EA) at "Fengfu"(GV16), "Taichong"(LR3), and "Zusanli"(ST36) on mitophagy mediated by silencing regulatory protein 3 (SIRT3)/ PTEN induced putative kinase 1 (PINK1)/PARK2 gene coding protein (Parkin) in the midbrain substantia nigra of Parkinson's disease (PD) mice, and to explore the potential mechanisms of EA in treating PD. METHODS: C57BL/6 mice were randomly divided into the control, model, EA, and sham EA groups, with 12 mice in each group...
March 25, 2024: Zhen Ci Yan Jiu, Acupuncture Research
https://read.qxmd.com/read/38491377/effects-of-latroeggtoxin-vi-on-dopamine-and-%C3%AE-synuclein-in-pc12-cells-and-the-implications-for-parkinson-s-disease
#8
JOURNAL ARTICLE
Dianmei Yu, Haiyan Wang, Yiwen Zhai, Zhixiang Lei, Minglu Sun, Si Chen, Panfeng Yin, Xianchun Wang
BACKGROUND: Parkinson's disease (PD) is characterized by death of dopaminergic neurons leading to dopamine deficiency, excessive α-synuclein facilitating Lewy body formation, etc. Latroeggtoxin-VI (LETX-VI), a proteinaceous neurotoxin discovered from the eggs of spider L. tredecimguttatus, was previously found to promote the synthesis and release of PC12 cells, showing a great potential as a drug candidate for PD. However, the relevant mechanisms have not been understood completely...
March 16, 2024: Biological Research
https://read.qxmd.com/read/38481801/mtdna-cgas-sting-axis-dependent-nlrp3-inflammasome-activation-contributes-to-postoperative-cognitive-dysfunction-induced-by-sevoflurane-in-mice
#9
JOURNAL ARTICLE
Nan-Shi-Yu Yang, Wen-Jing Zhong, Han-Xi Sha, Chen-Yu Zhang, Ling Jin, Jia-Xi Duan, Jian-Bing Xiong, Zhi-Jian You, Yong Zhou, Cha-Xiang Guan
The activation of NLRP3 inflammasome in microglia is critical for neuroinflammation during postoperative cognitive dysfunction (POCD) induced by sevoflurane. However, the molecular mechanism by which sevoflurane activates the NLRP3 inflammasome in microglia remains unclear. The cGAS-STING pathway is an evolutionarily conserved inflammatory defense mechanism. The role of the cGAS-STING pathway in sevoflurane-induced NLRP3 inflammasome-dependent neuroinflammation and the underlying mechanisms require further investigation...
2024: International Journal of Biological Sciences
https://read.qxmd.com/read/38479634/neuroprotective-effects-of-cordycepin-on-mptp-induced-parkinson-s-disease-mice-via-suppressing-pi3k-akt-mtor-and-mapk-mediated-neuroinflammation
#10
JOURNAL ARTICLE
Linhai Wang, Shu Tian, Sisi Ruan, Jingjing Wei, Sijia Wei, Weiwei Chen, Hangcui Hu, Weiwei Qin, Yan Li, Hang Yuan, Jian Mao, Yan Xu, Jianping Xie
Parkinson's disease (PD) is a prevalent progressive and multifactorial neurodegenerative disorder. Cordycepin is known to exhibit antitumor, anti-inflammatory, antioxidative stress, and neuroprotective effects; however, few studies have explored the neuroprotective mechanism of cordycepin in PD. Using a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced mouse model, we investigated the impact of cordycepin on PD and its underlying molecular mechanisms. The findings indicated that cordycepin significantly mitigated MPTP-induced motor dysfunction and neuroapoptosis, diminished the loss of dopaminergic neurons in the striatum-substantia nigra pathway, elevated striatal monoamine levels and its metabolites, and increased the levels of striatal monoamine and its metabolites, and inhibited the polarization of microglia and the expression of pro-inflammatory factors...
March 11, 2024: Free Radical Biology & Medicine
https://read.qxmd.com/read/38479621/new-sesquiterpenoids-with-neuroprotective-effects-in-vitro-and-in-vivo-from-the-picrasma-chinensis
#11
JOURNAL ARTICLE
Xian-Zhe Fan, Jia-Qi Song, Xin-Yi Shi, Jin-Fang Zhou, Rui-Juan Yuan, Ting Liu, Xiang-Qian Kong, Ya-Si Huang, Li-Jun Zhang, Hai-Bing Liao
Three undescribed sesquiterpenes, designed as pichinenoid A-C (1-3), along with nine known ones (4-12) were isolated from the stems and leaves of Picrasma chinensis. The new isolates including their absolute configurations were elucidated based on extensive spectroscopic methods, single crystal X-ray diffraction, and electronic circular dichroism (ECD) experiments, as well as comparison with literature data. Structurally, compounds 1 and 2 are descending sesquiterpenes, while pichinenoid C (3) is a rare sesquiterpene bearing a 2-methylenebut-3-enoic acid moiety at the C-6 side chain...
March 11, 2024: Fitoterapia
https://read.qxmd.com/read/38479556/early-b-cell-factor-3-ebf3-attenuates-parkinson-s-disease-through-directly-regulating-contactin-associated-protein-like-4-cntnap4-transcription-an-experimental-study
#12
JOURNAL ARTICLE
Wentao Hu, Menghan Wang, Guifang Sun, Limin Zhang, Hong Lu
Parkinson's disease (PD) is a gradually debilitating neurodegenerative syndrome. Here, we analyzed GSE7621 chip data obtained from the Gene Expression Omnibus (GEO) database to explore the pathogenesis of PD. Early B Cell Factor 3 (EBF3), a member of the highly evolutionarily conserved EBF-transcription factor family, is involved in neuronal development. EBF3 expression is low in the substantia nigra of patients with PD. However, whether EBF3 is implicated in dopaminergic neuron death during PD has not yet been investigated...
March 11, 2024: Cellular Signalling
https://read.qxmd.com/read/38478195/effects-of-the-glucocorticoid-mediated-mitochondrial-translocation-of-glucocorticoid-receptors-on-oxidative-stress-and-pyroptosis-in-bv-2-microglia
#13
JOURNAL ARTICLE
Ruonan Dang, Xuyang Hou, Xinglan Huang, Caifeng Huang, Xiaoqing Zhao, Xingrong Wang, Ning Zhang, Yuqi Yang, Nan Li, Sheng Liu, Peng Yan, Ping Fan, Xinghua Song, Suiying Zhang, Yuqiong Deng, Xiping Cheng, Xinhua Xia
Microglia are resident macrophages within the central nervous system, serving as the first responders to neuroinflammation. Glucocorticoids (GCs) may cause damage to brain tissue, but the specific mechanism remains unclear. This study was divided into two parts: a glucocorticoid receptor (GR) mitochondrial translocation intervention experiment and a mitochondrial oxidative stress inhibition experiment. BV-2 microglia were stimulated with dexamethasone (DEX) and treated with either tubastatin-A or mitoquinone (MitoQ) for 24 h...
March 13, 2024: Journal of Molecular Neuroscience: MN
https://read.qxmd.com/read/38477420/lrrk2-regulates-ferroptosis-through-the-system-xc-gsh-gpx4-pathway-in-the-neuroinflammatory-mechanism-of-parkinson-s-disease
#14
JOURNAL ARTICLE
Zijian Zheng, Shushan Zhang, Xinjie Liu, Xiangrong Wang, Cheng Xue, Xiao Wu, Xinran Zhang, Xinping Xu, Zheng Liu, Longping Yao, Guohui Lu
Parkinson's disease (PD) is the most prevalent neurodegenerative disorder. Neuroinflammation mediated by activated microglia and apoptosis of dopaminergic (DA) neurons in the midbrain are its primary pathological manifestations. Leucine-rich repeat protein kinase 2 (LRRK2) kinase has been observed to increase expression during neuroinflammation, however, the effect of LRRK2 on microglia activation remains poorly understood. In this study, we have established lipopolysaccharide (LPS) treated BV2 cells and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) models for both in vivo and in vitro investigation...
March 13, 2024: Journal of Cellular Physiology
https://read.qxmd.com/read/38473763/linalool-a-fragrance-compound-in-plants-protects-dopaminergic-neurons-and-improves-motor-function-and-skeletal-muscle-strength-in-experimental-models-of-parkinson-s-disease
#15
JOURNAL ARTICLE
Wan-Hsuan Chang, Hung-Te Hsu, Chih-Cheng Lin, Li-Mei An, Chien-Hsing Lee, Horng-Huey Ko, Chih-Lung Lin, Yi-Ching Lo
Parkinson's disease (PD) is a common neurodegenerative disorder characterized by the gradual loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc), resulting in reduced dopamine levels in the striatum and eventual onset of motor symptoms. Linalool (3,7-dimethyl-1,6-octadien-3-ol) is a monoterpene in aromatic plants exhibiting antioxidant, antidepressant, and anti-anxiety properties. The objective of this study is to evaluate the neuroprotective impacts of linalool on dopaminergic SH-SY5Y cells, primary mesencephalic and cortical neurons treated with 1-methyl-4-phenylpyridinium ion (MPP+ ), as well as in PD-like mice induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)...
February 21, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38471370/asiaticoside-exerts-neuroprotection-through-targeting-nlrp3-inflammasome-activation
#16
JOURNAL ARTICLE
Ziliang He, Yeye Hu, Ying Zhang, Jing Xie, Zhiqiang Niu, Guigui Yang, Ji Zhang, Zixuan Zhao, Shuai Wei, Haifeng Wu, Weicheng Hu
BACKGROUND: Parkinson's disease (PD), a neurodegenerative disorder, is characterized by motor symptoms due to the progressive loss of dopaminergic neurons in the substantia nigra (SN) and striatum (STR), alongside neuroinflammation. Asiaticoside (AS), a primary active component with anti-inflammatory and neuroprotective properties, is derived from Centella asiatica. However, the precise mechanisms through which AS influences PD associated with inflammation are not yet fully understood...
February 28, 2024: Phytomedicine
https://read.qxmd.com/read/38468197/species-delimitation-of-tea-plants-camellia-sect-thea-based-on-super-barcodes
#17
JOURNAL ARTICLE
Yinzi Jiang, Junbo Yang, Ryan A Folk, Jianli Zhao, Jie Liu, Zhengshan He, Hua Peng, Shixiong Yang, Chunlei Xiang, Xiangqin Yu
BACKGROUND: The era of high throughput sequencing offers new paths to identifying species boundaries that are complementary to traditional morphology-based delimitations. De novo species delimitation using traditional or DNA super-barcodes serve as efficient approaches to recognizing putative species (molecular operational taxonomic units, MOTUs). Tea plants (Camellia sect. Thea) form a group of morphologically similar species with significant economic value, providing the raw material for tea, which is the most popular nonalcoholic caffeine-containing beverage in the world...
March 11, 2024: BMC Plant Biology
https://read.qxmd.com/read/38466012/investigating-the-effect-of-an-anti-inflammatory-drug-in-determining-nurr1-expression-and-thus-exploring-the-progression-of-parkinson-s-disease
#18
JOURNAL ARTICLE
X Zheng, Z Zhao, L Zhao
Nonsteroidal anti-inflammatory drugs are the most widely used drugs for Parkinson's disease (PD), of which ibuprofen shows positive effects in suppressing symptoms; however, the associated risk needs to be addressed in different pathological stages. Initially, we developed an initial and advanced stage of the Parkinson disease mouse model by intraperitoneal injection of MPTP (20 mg/kg; 1-methyl-4-phenyl-1,2,3,6-tetrahydro-pyridine) for 10 and 20 days, respectively. Subsequently, ibuprofen treatment was administered for 2 months, and a pole test, rotarod test, histology, immunohistochemistry, and western blotting were performed to determine neuronal motor function...
March 11, 2024: Physiological Research
https://read.qxmd.com/read/38464835/phosphoglycerate-mutase-5-aggravates-alcoholic-liver-disease-through-disrupting-vdac-1-dependent-mitochondrial-integrity
#19
JOURNAL ARTICLE
Tian Xia, Jiachi Yu, Ye Chen, Xing Chang, Miao Meng
Alcoholic liver disease (ALD) poses a substantial global health challenge, with its pathogenesis deeply rooted in mitochondrial dysfunction. Our study explores the pivotal roles of Phosphoglycerate mutase family member 5 (Pgam5) and Voltage-Dependent Anion Channel 1 (VDAC1) in the progression of ALD, providing novel insights into their interplay and impact on mitochondrial integrity. We demonstrate that Pgam5 silencing preserves hepatocyte viability and attenuates ethanol-induced apoptosis, underscoring its detrimental role in exacerbating hepatocyte dysfunction...
2024: International Journal of Medical Sciences
https://read.qxmd.com/read/38461204/the-potential-of-targeting-autophagy-related-non-coding-rnas-in-the-treatment-of-alzheimer-s-and-parkinson-s-diseases
#20
REVIEW
Abdolkarim Talebi Taheri, Zakieh Golshadi, Hamidreza Zare, Azam Alinaghipour, Zahra Faghihi, Ehsan Dadgostar, Zeinab Tamtaji, Michael Aschner, Hamed Mirzaei, Omid Reza Tamtaji, Fatemeh Nabavizadeh
Clearance of accumulated protein aggregates is one of the functions of autophagy. Recently, a clearer understanding of non-coding RNAs (ncRNAs) functions documented that ncRNAs have important roles in several biological processes associated with the development and progression of neurodegenerative disorders. Subtypes of ncRNA, including microRNA (miRNA), long noncoding RNA (lncRNA), and circular RNA (circRNA), are commonly dysregulated in neurodegenerative disorders such as Alzheimer and Parkinson diseases...
March 10, 2024: Cellular and Molecular Neurobiology
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