keyword
MENU ▼
Read by QxMD icon Read
search

MPTP

keyword
https://www.readbyqxmd.com/read/29150919/a-focus-on-the-beneficial-effects-of-alpha-synuclein-and-a-re-appraisal-of-synucleinopathies
#1
Larisa Ryskalin, Carla L Busceti, Fiona Limanaqi, Francesca Biagioni, Stefano Gambardella, Francesco Fornai
Alpha synuclein (α-syn) belongs to a class of proteins which are commonly considered to play a detrimental role in neuronal survival. This assumption is based on the occurrence of a severe neuronal degeneration in patients carrying a multiplication of the α-syn gene (SNCA) and in a variety of experimental models, where overexpression of α-syn leads to cell death and neurological impairment. In these conditions, a higher amount of normally structured α-syn produces a damage, which is even worse compared with that produced by α-syn owing an abnormal structure (as occurring following point gene mutations)...
November 16, 2017: Current Protein & Peptide Science
https://www.readbyqxmd.com/read/29150520/dopaminergic-neurotoxins-induce-cell-death-by-attenuating-nf-%C3%AE%C2%BAb-mediated-regulation-of-trpc1-expression-and-autophagy
#2
Pramod Sukumaran, Yuyang Sun, Neil Antonson, Brij B Singh
Alterations in Ca(2+) homeostasis affect neuronal survival. However, the identity of Ca(2+) channels and the mechanisms underlying neurotoxin-induced neuronal degeneration are not well understood. In this study, the dopaminergic neurotoxins 6-hydroxydopamine (6-OHDA) and 1-methyl -4-phenylpyridium ions (MPP(+)/MPTP), which mimic Parkinson's disease (PD), induced neuronal degeneration by decreasing store-mediated Ca(2+) entry. The function of the transient receptor potential canonical (TRPC)-1 channel was decreased upon exposure to the neurotoxins, followed by a decrease in TRPC1 expression...
November 17, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29150332/organic-arsenicals-target-thioredoxin-reductase-followed-by-oxidative-stress-and-mitochondrial-dysfunction-resulting-in-apoptosis
#3
Xiao-Yang Fan, Yu-Jiao Liu, Kai Chen, Feng-Lei Jiang, Yan-Jun Hu, Dan Liu, Yi Liu, Yu-Shu Ge
Considering the vital role of cellular redox state, more and more researches focus on the design of drugs targeting thioredoxin reductase (TrxR), an important enzyme in maintaining the balance of cellular redox. Here two organic arsenicals, 2-(((4-(1,3,2-dithiarsinan-2-yl) phenyl) imino) methyl) phenol (PIM-PAO-PDT) and N-(4-(1,3,2-dithiarsinan-2-yl) phenyl)-2-hydroxybenzamide (PAM-PAO-PDT), bearing the S-As-S chemical scaffold and different linking groups have been synthesized, and both of them show the better inhibitory activity and selectivity towards HL-60 cells...
May 6, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29136370/ochratoxin-a-induced-apoptosis-of-ipec-j2-cells-through-ros-mediated-mitochondrial-permeability-transition-pore-opening-pathway
#4
Hong Wang, Ying Chen, Nianhui Zhai, Xingxiang Chen, Fang Gan, Hu Li, Kehe Huang
With the purpose to explore the mechanisms associated with the intestinal toxicity of OTA, an intestinal porcine epithelial cell line (IPEC-J2) was applied in this study as in vitro models for intestinal epithelium. The results confirmed that OTA induced IPEC-J2 cell toxicity by MTT assay and apoptosis by Hoechst 33258 staining and flow cytometer analysis. And then, we observed that OTA induced the mitochondrial reactive oxygen species (ROS) production and mitochondrial permeability transition pore (mPTP) opening by confocal microscopy...
November 14, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29125839/csseverin-inhibits-apoptosis-through-mitochondria-mediated-pathways-triggered-by-ca2-dyshomeostasis-in-hepatocarcinoma-plc-cells
#5
Mengchen Shi, Lina Zhou, Lu Zhao, Mei Shang, Tongtong He, Zeli Tang, Hengchang Sun, Pengli Ren, Zhipeng Lin, Tingjin Chen, Jinyun Yu, Jin Xu, Xinbing Yu, Yan Huang
BACKGROUND: Numerous experimental and epidemiological studies have demonstrated a link between Clonorchis sinensis (C. sinensis) infestation and cholangiocarcinoma (CCA) as well as hepatocellular carcinoma (HCC). The underlying molecular mechanism involved in the malignancy of CCA and HCC has not yet been addressed. Csseverin, a component of the excretory/secretory products of C. sinensis (CsESPs), was confirmed to cause obvious apoptotic inhibition in the human HCC cell line PLC. However, the antiapoptotic mechanism is unclear...
November 10, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29124672/radio-electric-asymmetric-conveyer-technology-modulates-neuroinflammation-in-a-mouse-model-of-neurodegeneration
#6
Maria Antonietta Panaro, Alessandra Aloisi, Giuseppe Nicolardi, Dario Domenico Lofrumento, Francesco De Nuccio, Velia La Pesa, Antonia Cianciulli, Rosaria Rinaldi, Rosa Calvello, Vania Fontani, Salvatore Rinaldi
In this study, the effects of Radio Electric Asymmetric Conveyer (REAC), a non-invasive physical treatment, on neuroinflammatory responses in a mouse model of parkinsonism induced by intoxication with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), were investigated in vivo. We found that the REAC tissue optimization treatment specific for neuro-regenerative purposes (REAC TO-RGN-N) attenuated the inflammatory picture evoked by MPTP-induced nigro-striatal damage in mice, decreasing the levels of pro-inflammatory molecules and increasing anti-inflammatory mediators...
November 10, 2017: Neuroscience Bulletin
https://www.readbyqxmd.com/read/29123128/pink1-mediated-phosphorylation-of-letm1-regulates-mitochondrial-calcium-transport-and-protects-neurons-against-mitochondrial-stress
#7
En Huang, Dianbo Qu, Tianwen Huang, Nicoletta Rizzi, Wassamon Boonying, Dorothy Krolak, Paolo Ciana, John Woulfe, Christine Klein, Ruth S Slack, Daniel Figeys, David S Park
Mutations in PTEN-induced kinase 1 (PINK1) result in a recessive familial form of Parkinson's disease (PD). PINK1 loss is associated with mitochondrial Ca(2+) mishandling, mitochondrial dysfunction, as well as increased neuronal vulnerability. Here we demonstrate that PINK1 directly interacts with and phosphorylates LETM1 at Thr192 in vitro. Phosphorylated LETM1 or the phospho-mimetic LETM1-T192E increase calcium release in artificial liposomes and facilitates calcium transport in intact mitochondria. Expression of LETM1-T192E but not LETM1-wild type (WT) rescues mitochondrial calcium mishandling in PINK1-deficient neurons...
November 9, 2017: Nature Communications
https://www.readbyqxmd.com/read/29115479/overexpression-of-mir%C3%A2-185-inhibits-autophagy-and-apoptosis-of-dopaminergic-neurons-by-regulating-the-ampk-mtor-signaling-pathway-in-parkinson-s-disease
#8
Zhi Wen, Jie Zhang, Peng Tang, Ning Tu, Ke Wang, Guangyao Wu
Parkinson's disease (PD) is an age‑associated neurodegenerative disorder characterized by the death of dopaminergic neurons in the substantia nigra pars compacta. Activation of 5'‑adenosine monophosphate‑activated protein kinase (AMPK) has been suggested to be associated with PD pathogenesis. The aim of the present study was to investigate the effects of the aberrant expression of microRNA‑185 (miR‑185) in PD. A 1‑methyl‑4‑phenyl‑1,2,3,6‑tetrahydropyridine (MPTP)‑induced in vitro model of PD was generated using the human SH‑SY5Y dopaminergic neuroblastoma cell line, in order to examine the potential molecular mechanisms underlying the roles of miR‑185 in PD...
October 26, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29096532/effects-of-chronic-aspartame-consumption-on-mptp-induced-parkinsonism-in-male-and-female-mice
#9
Shaimaa Nasr Amin, Sherif Sabry Hassan, Laila Ahmed Rashed
BACKGROUND: Parkinson's disease is a progressive neurodegenerative disorder. Aspartame (l-aspartyl-l-phenylalanine methyl ester), a low calorie sweetener used in foods and beverages. OBJECTIVES: This study investigated the effect of chronic aspartame intake on Parkinsonism induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). METHOD: Forty-eight mice (24 males and 24 females): control, aspartame, MPTP, and aspartame + MPTP groups tested by Y-maze, stepping, forced swimming and olfactory preference tests...
November 2, 2017: Archives of Physiology and Biochemistry
https://www.readbyqxmd.com/read/29089984/interleukin-4-induced-neuroprotection-and-regulation-of-microglia-activation-as-a-therapeutic-approach-in-the-mptp-model-of-parkinson-s-disease
#10
Björn Spittau
No abstract text is available yet for this article.
September 2017: Neural Regeneration Research
https://www.readbyqxmd.com/read/29089467/suppression-of-stim1-reduced-intracellular-calcium-concentration-and-attenuated-hypoxia-reoxygenation-induced-apoptosis-in-h9c2-cells
#11
Fei He, Qianfu Wu, Banglong Xu, Xiaocheng Wang, Jixiong Wu, Li Huang, Jing Cheng
Objective: Previous studies have demonstrated STIM1-mediated store-operated Ca(2+) entry(SOCE) contributes to intracellular Ca(2+) accumulation. The present study aimed to investigate the expression of STIM1 and Orai1/TRPC1 in the context of myocardial ischemia/reperfusion injury(MIRI) and the effect of STIM1 inhibition on Ca(2+) accumulation and apoptosis in H9c2 cardiomyocytes subjected to hypoxia/reoxygenation(H/R). Methods: Expression of STIM1/Orai1/TRPC1 was determined by RT-PCR and Western Blot in mice subjected to MIRI and H9C2 cardiomyocytes subjected to H/R...
October 31, 2017: Bioscience Reports
https://www.readbyqxmd.com/read/29078122/reliability-of-the-twitch-evoked-skeletal-muscle-electromechanical-efficiency-a-ratio-between-tensiomyogram-and-m-wave-amplitudes
#12
Armin Paravlić, Damir Zubac, Boštjan Šimunič
Electromechanical efficiency (EME) of skeletal muscle represents the dissociation between the mechanomyographic (MMG) to electromyographic (EMG) amplitudes and was commonly used in clinical settings (e.g. muscle disease, atrophy, rehabilitation). However, due to lower reliability and of both MMG and EMG as well as lower validity of MMG we aimed to establish the intra-day, inter-day and inter-rater reliability of modified EME. Reliability was examined for maximal soleus twitch amplitudes of tensiomyographic (Dm) and M-wave (Mptp) responses, as well as for EME derived as Dm/Mptp, in 18 healthy participants (55% males; 30...
October 19, 2017: Journal of Electromyography and Kinesiology
https://www.readbyqxmd.com/read/29076602/diffusion-tensor-imaging-marks-dopaminergic-and-serotonergic-lesions-in-the-parkinsonian-monkey
#13
Elise Météreau, Maude Beaudoin-Gobert, Sandra Duperrier, Stéphane Thobois, Léon Tremblay, Véronique Sgambato-Faure
BACKGROUND: Diffusion tensor imaging has received major interest to highlight markers of neurodegeneration in Parkinson's disease. Whether the alteration of diffusion parameters mostly depicts dopaminergic lesions or can also reveal serotonergic denervation remains a question. OBJECTIVES: The aim of this study was to determine the best diffusion tensor imaging markers of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and 3,4-methylene-dioxy-methamphetamine (MDMA; also known as ecstasy) lesions in the nonhuman primate...
October 27, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/29071302/paraquat-and-mptp-induce-neurodegeneration-and-alteration-in-the-expression-profile-of-micrornas-the-role-of-transcription-factor-nrf2
#14
Qingqing Wang, Nan Ren, Zhipeng Cai, Qingxia Lin, Zhangjing Wang, Qunwei Zhang, Siying Wu, Huangyuan Li
Both transcription factors (TFs) and microRNAs (miRNAs) can exert a widespread impact on gene expression. In the present study, we investigated the role of Nrf2 in paraquat-induced intracorporeal neurodegeneration and miRNA expression by exposing Nrf2 wild-type and knockout mice to paraquat (PQ) or 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Exposure to 10 mg/kg PQ or 30 mg/kg MPTP caused damage to nerve cells in the substantia nigra (SN) in both Nrf2 (+/+) and Nrf2 (-/-) ICR mice, which included cell morphological changes, detectable apoptosis and a significant reduction in the number of dopaminergic (DA) neurons...
2017: NPJ Parkinson's Disease
https://www.readbyqxmd.com/read/29063978/mst1-regulates-colorectal-cancer-stress-response-via-inhibiting-bnip3-related-mitophagy-by-activation-of-jnk-p53-pathway
#15
Qi Li, Feng Qi, Xiangchao Meng, Chenpei Zhu, Yingtang Gao
The Hippo-Mst1 pathway is associated with tumor development and progression. However, little evidence is available for its role in colorectal cancer (CRC) stress response via mitochondrial homeostasis. In this study, we conducted gain-of function assay about Mst1 in CRC via adenovirus transfection. Then, cellular viability and apoptosis were measured via MTT, TUNEL assay, and typan blue staining. Mitochondrial function was detected via JC1 staining, mPTP opening assay, and immunofluorescence of cyt-c. Mitophagy was observed via western blots and immunofluorescence...
October 24, 2017: Cell Biology and Toxicology
https://www.readbyqxmd.com/read/29053638/neuroprotective-surgical-strategies-in-parkinson-s-disease-role-of-preclinical-data
#16
REVIEW
Napoleon Torres, Jenny Molet, Cecile Moro, John Mitrofanis, Alim Louis Benabid
Although there have been many pharmacological agents considered to be neuroprotective therapy in Parkinson's disease (PD) patients, neurosurgical approaches aimed to neuroprotect or restore the degenerative nigrostriatal system have rarely been the focus of in depth reviews. Here, we explore the neuroprotective strategies involving invasive surgical approaches (NSI) using neurotoxic models 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and 6-hydroxydopamine (6-OHDA), which have led to clinical trials. We focus on several NSI approaches, namely deep brain stimulation of the subthalamic nucleus, glial neurotrophic derived factor (GDNF) administration and cell grafting methods...
October 20, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29050969/a-novel-selective-mao-b-inhibitor-with-neuroprotective-and-anti-parkinsonian-properties
#17
Hugh H Chan, Man Kit Tse, Saravana Kumar, Lang Zhuo
We previously reported that 1,3-bisbenzylimidazolium (DBZIM) bromide was neuroprotective for the dopaminergic system in Parkinson's disease (PD) models of rodent, however the underlying mechanism was unclear. We currently further confirmed that DBZIM ameliorated the Parkinsonian motor deficit and protected the nigrostriatal tract from the neurotoxicity of 1-methyl-4-(2'-methylphenyl)-1,2,3,6-tetrahydropyridine (2'-CH3-MPTP) in C57Bl/6 mice. The dopaminergic degeneration in the substantia nigra par compacta (SNc) and striatum was analyzed by immunohistochemistry while the monoamine oxidase B (MAO-B) inhibition effect of DBZIM was determined by enzyme kinetics...
October 17, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29032054/role-of-ethanolic-extract-of-bacopa-monnieri-against-1-methyl-4-phenyl-1-2-3-6-tetrahydropyridine-mptp-induced-mice-model-via-inhibition-of-apoptotic-pathways-of-dopaminergic-neurons
#18
Babita Singh, Shivani Pandey, Satyndra Kumar Yadav, Rajesh Verma, Surya Pratap Singh, Abbas Ali Mahdi
Parkinson's disease (PD) is a neurodegenerative disease which causes rigidity, resting tremor and postural instability. The neuroprotective effects of an ethanolic extract of Bacopa monnieri (BM) were evaluated in a Parkinsonian mice model induced by the MPTP. The present study investigates the mechanisms of neuroprotection elicited by BM, an herb traditionally recognized by the Indian system of medicine, Ayurveda. An ethanolic extract of BM was co-treated with the MPTP induced mouse model of PD and was shown to significantly rescue the motor behaviour (Rotarod, Grip Strength and Foot Printing test)...
October 12, 2017: Brain Research Bulletin
https://www.readbyqxmd.com/read/29031076/synthesis-and-evaluation-of-new-pyridyl-pyrazinyl-thiourea-derivatives-neuroprotection-against-amyloid-%C3%AE-induced-toxicity
#19
Jung-Eun Park, Ahmed Elkamhawy, Ahmed H E Hassan, Ae Nim Pae, Jiyoun Lee, Sora Paik, Beoung-Geon Park, Eun Joo Roh
Herein, we report synthesis and evaluation of new twenty six small molecules against β amyloid (Aβ)-induced opening of mitochondrial permeability transition pore (mPTP) using JC-1 assay which measures the change of mitochondrial membrane potential (ΔΨm). The neuroprotective effect of seventeen compounds against Aβ-induced mPTP opening was superior to that of the standard Cyclosporin A (CsA). Fifteen derivatives eliciting increased green to red fluorescence percentage less than 40.0% were evaluated for their impact on ATP production, cell viability and neuroprotection against Aβ-induced neuronal cell death...
December 1, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29030221/inhibition-of-bdnf-production-by-mpp-through-up-regulation-of-mir-210-3p-contributes-to-dopaminergic-neuron-damage-in-mptp-model
#20
Shan Zhang, Shu Chen, Anmin Liu, Jungang Wan, Lingwen Tang, Niandong Zheng, Yi Xiong
The neurotrophin brain-derived neurotrophic factor (BDNF) has been involved in supporting of neuron survival. The observation of reduced level of BDNF in the substantia nigra (SN) of Parkinson's disease (PD) patients suggests its important role in neuron protection in PD pathogenesis. However, the mechanism underlying the down-regulation of BDNF in PD was largely unknown. In this study, we found that miR-210-3p is involved in the regulation of BDNF production by 1-methyl-4-phenylpyridinium (MPP(+)). MPP(+) inhibits the BDNF production in SH-SY5Y cells through a transcription independent manner...
October 10, 2017: Neuroscience Letters
keyword
keyword
69090
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"