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Mptp and apathy

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https://www.readbyqxmd.com/read/26135399/neuroimaging-analysis-of-the-dopamine-basis-for-apathetic-behaviors-in-an-mptp-lesioned-primate-model
#1
COMPARATIVE STUDY
LinLin Tian, Yuanxuan Xia, Hubert P Flores, Meghan C Campbell, Stephen M Moerlein, Joel S Perlmutter
Apathy commonly occurs in Parkinson disease (PD) patients; however, the role of dopamine in the pathophysiology of apathy remains elusive. We previously demonstrated that dopaminergic dysfunction within the ventral tegmental area (VTA)-nucleus accumbens (NAcc) pathway contributes to the manifestation of apathetic behaviors in monkeys treated with the selective dopaminergic neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). We now extend these studies to identify dopaminergic dysfunction in cortical regions that correlate with development of apathetic behaviors...
2015: PloS One
https://www.readbyqxmd.com/read/22579525/dopamine-pathway-loss-in-nucleus-accumbens-and-ventral-tegmental-area-predicts-apathetic-behavior-in-mptp-lesioned-monkeys
#2
C A Brown, M C Campbell, M Karimi, S D Tabbal, S K Loftin, L L Tian, S M Moerlein, J S Perlmutter
Apathy, primarily defined as a lack of motivation, commonly occurs in people with Parkinson disease (PD). Although dysfunction of basal ganglia pathways may contribute to apathy, the role of dopamine remains largely unknown. We investigated the role of dopaminergic pathways in the manifestation of apathetic behaviors by measuring the effects of the selective dopaminergic neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on monkeys' willingness to attempt goal directed behaviors, distinct from their ability to perform tasks...
July 2012: Experimental Neurology
https://www.readbyqxmd.com/read/20206263/genes-regulated-in-mptp-treated-macaques-and-human-parkinson-s-disease-suggest-a-common-signature-in-prefrontal-cortex
#3
Markus Storvik, Marie-Jeanne Arguel, Sandra Schmieder, Audrey Delerue-Audegond, Qin Li, Chuan Qin, Anne Vital, Bernard Bioulac, Christian E Gross, Garry Wong, Jean-Louis Nahon, Erwan Bezard
The presymptomatic phase of Parkinson's disease (PD) is now recognized as a prodromal phase, with compensatory mechanism masking its progression and non-motor early manifestations, such as depression, cognitive disturbances and apathy. Those mechanisms were thought to be strictly dopamine-mediated until recent advances have shed light upon involvement of putative outside-basal ganglia, i.e. cortical, structures. We took advantage of our progressive 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated macaque model to monitor whole genome transcriptional changes in several brain areas...
June 2010: Neurobiology of Disease
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