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https://www.readbyqxmd.com/read/28632899/novel-intracytoplasmic-inclusions-immunoreactive-for-phosphorylated-tdp43-and-cystatin-c-in-anterior-horn-cells-in-a-case-of-sporadic-amyotrophic-lateral-sclerosis
#1
Masayuki Shintaku, Daita Kaneda, Kiyomitsu Oyanagi
Novel intracytoplasmic inclusions immunoreactive for phosphorylated transactivation response DNA-binding protein 43 (p-TDP43), cystatin C, and transferrin were found in anterior horn cells in a case of sporadic amyotrophic lateral sclerosis (ALS). The patient was a 59-year-old woman, who died of ALS after a clinical course of 8 years. She had been receiving mechanical support for respiration for 6 years and in a "totally locked-in" state for 4 years prior to death. The spinal cord showed severe degeneration involving the anterior and lateral funiculi, whereas the posterior funiculus was preserved...
June 20, 2017: Neuropathology: Official Journal of the Japanese Society of Neuropathology
https://www.readbyqxmd.com/read/28566399/oxidised-zirconium-versus-cobalt-alloy-bearing-surfaces-in-total-knee-arthroplasty-3d-laser-scanning-of-retrieved-polyethylene-inserts
#2
F L Anderson, C N Koch, M E Elpers, T M Wright, S B Haas, T J Heyse
AIMS: We sought to establish whether an oxidised zirconium (OxZr) femoral component causes less loss of polyethylene volume than a cobalt alloy (CoCr) femoral component in total knee arthroplasty. MATERIALS AND METHODS: A total of 20 retrieved tibial inserts that had articulated with OxZr components were matched with 20 inserts from CoCr articulations for patient age, body mass index, length of implantation, and revision diagnosis. Changes in dimensions of the articular surfaces were compared with those of pristine inserts using laser scanning...
June 2017: Bone & Joint Journal
https://www.readbyqxmd.com/read/28542147/restricting-the-induction-of-ngf-in-ovarian-stroma-engenders-selective-follicular-activation-through-the-mtor-signaling-pathway
#3
Yuanlin He, Xiaoxu Peng, Tinghe Wu, Weijie Yang, Wenwen Liu, Jing Zhang, Yiping Su, Feifei Kong, Xiaowei Dou, Jing Li
In mammalian ovaries, primordial follicles remain in a quiescent state until activation by the surrounding microenvironment. Ovarian intervention, for example, ovarian cystectomy, ovarian wedge resection or laser drilling therapies for polycystic ovarian syndrome, has long been reported to change follicular development by an unknown mechanism(s). Herein, we established a murine model with partial ovarian resection of one ovary unilaterally, with the contralateral ovary undamaged. We found the injury accelerated follicular activation and development through the mTORC1 signaling pathway...
May 25, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28397482/genetic-polymorphism-of-epidermal-growth-factor-rs4444903-influences-susceptibility-to-hcv-related-liver-cirrhosis-and-hepatocellular-carcinoma-in-a-chinese-han-population
#4
Shitian Zhang, Kunyan Qiao, Congdoanh Trieu, Zhixiao Huo, Qinghai Dai, Yanan Du, Wei Lu, Wei Hou
BACKGROUND: Genetic polymorphism in the epidermal growth factor (EGF, rs4444903) gene has been demonstrated to be associated with the clinical deterioration in hepatitis C virus (HCV)-related liver cirrhosis (LC) and the development of hepatocellular carcinoma (HCC). Whether this single nucleotide polymorphism (SNP) influences susceptibility to HCV-related LC and HCC in the Chinese Han population is largely unknown. METHODS: In this case-control study, a total of 187 Chinese Han patients with chronic HCV infection were enrolled, including 62 HCV-related LC patients, 46 HCV-related HCC patients, and 79 chronic hepatitis C (CHC) patients without LC and HCC, and the genetic polymorphism was genotyped via a matrix-assisted laser desorption/ionization time of flight mass spectrometry (MALDI-TOF MS) assay...
April 1, 2017: Clinical Laboratory
https://www.readbyqxmd.com/read/28385302/subclassification-of-primary-angle-closure-using-anterior-segment-optical-coherence-tomography-and-ultrasound-biomicroscopic-parameters
#5
Junki Kwon, Kyung Rim Sung, Seungbong Han, Ye Ji Moon, Joong Won Shin
PURPOSE: To classify eyes with primary angle closure (PAC) in terms of the features visualized using anterior segment optical coherence tomography (AS-OCT) and ultrasound biomicroscopy (UBM). DESIGN: Retrospective, observational study. PARTICIPANTS: A total of 73 eyes of 73 patients with PAC. METHODS: Participants' eyes that had undergone laser peripheral iridotomy (LPI) were imaged using AS-OCT and UBM under the same lighting conditions...
April 3, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28347715/preeclampsia-novel-insights-from-global-rna-profiling-of%C3%A2-trophoblast-subpopulations
#6
Matthew Gormley, Katherine Ona, Mirhan Kapidzic, Tamara Garrido-Gomez, Tamara Zdravkovic, Susan J Fisher
BACKGROUND: The maternal signs of preeclampsia, which include the new onset of high blood pressure, can occur because of faulty placentation. We theorized that transcriptomic analyses of trophoblast subpopulations in situ would lend new insights into the role of these cells in preeclampsia pathogenesis. OBJECTIVE: Our goal was to enrich syncytiotrophoblasts, invasive cytotrophoblasts, or endovascular cytotrophoblasts from the placentas of severe preeclampsia cases...
March 24, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28301678/effectiveness-of-adjunctive-interventions-for-accelerating-orthodontic-tooth-movement-a-systematic-review-of-systematic-reviews
#7
REVIEW
J Yi, J Xiao, H Li, Y Li, X Li, Z Zhao
This study was aimed to summarise published systematic reviews (SRs) that assess the effects of adjunctive interventions on the acceleration of orthodontic tooth movement (OTM). Electronic and manual searches were performed up to August 2016. Systematic reviews investigating the impact of adjunctive techniques on the promotion of OTM were included. The methodological quality of the included reviews was evaluated using the A Measurement Tool to Assess Systematic Reviews (AMSTAR) scale. The quality of evidence for each intervention was assessed using GRADE...
March 16, 2017: Journal of Oral Rehabilitation
https://www.readbyqxmd.com/read/28271015/lactate-based-optical-screening-of-dengue-virus-infection-in-human-sera-using-raman-spectroscopy
#8
Muhammad Bilal, Rahat Ullah, Saranjam Khan, Hina Ali, Muhammad Saleem, Mushtaq Ahmed
This study presents the screening of dengue virus (DENV) infection in human blood sera based on lactate concentration using Raman spectroscopy. A total of 70 samples, 50 from confirmed DENV infected patients and 20 from healthy volunteers have been used in this study. Raman spectra of all these samples have been acquired in the spectral range from 600 cm(-1) to 1800 cm(-1) using a 532 nm laser as an excitation source. Spectra of all these samples have been analyzed for assessing the biochemical changes resulting from infection...
February 1, 2017: Biomedical Optics Express
https://www.readbyqxmd.com/read/28262709/a-standardized-method-for-lectin-microarray-based-tissue-glycome-mapping
#9
Xia Zou, Maki Yoshida, Chiaki Nagai-Okatani, Jun Iwaki, Atsushi Matsuda, Binbin Tan, Kozue Hagiwara, Takashi Sato, Yoko Itakura, Erika Noro, Hiroyuki Kaji, Masashi Toyoda, Yan Zhang, Hisashi Narimatsu, Atsushi Kuno
The significance of glycomic profiling has been highlighted by recent findings that structural changes of glycans are observed in many diseases, including cancer. Therefore, glycomic profiling of the whole body (glycome mapping) under different physiopathological states may contribute to the discovery of reliable biomarkers with disease-specific alterations. To achieve this, standardization of high-throughput and in-depth analysis of tissue glycome mapping is needed. However, this is a great challenge due to the lack of analytical methodology for glycans on small amounts of endogenous glycoproteins...
March 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28242296/proteomic-and-histopathological-characterization-of-the-interface-between-oral-squamous-cell-carcinoma-invasion-fronts-and-non-cancerous-epithelia
#10
Tatsuya Abé, Satoshi Maruyama, Manabu Yamazaki, Bo Xu, Hamzah Babkair, Yoshimasa Sumita, Jun Cheng, Tadashi Yamamoto, Takashi Saku
Oral squamous cell carcinomas (SCCs) are frequently associated with pre-invasive lesions including carcinoma in-situ (CIS), and CISs further form lateral interfaces against surrounding normal or dysplastic epithelia (ND). At the interface where keratin (K) 17 positive (+) SCC/CIS cells are in contact with K13+ ND cells, "cell competition" must be evoked between two such different cell types. Thus, the aim of this study was to characterize the histopathology of the SCC/CIS-ND interface and to determine protein profiles around the interface by proteomics...
February 27, 2017: Experimental and Molecular Pathology
https://www.readbyqxmd.com/read/28123436/review-of-the-mechanisms-and-effects-of-noninvasive-body-contouring-devices-on-cellulite-and-subcutaneous-fat
#11
REVIEW
Zahra Alizadeh, Farzin Halabchi, Reza Mazaheri, Maryam Abolhasani, Mastaneh Tabesh
CONTEXT: Today, different kinds of non-invasive body contouring modalities, including cryolipolysis, radiofrequency (RF), low-level laser therapy (LLLT), and high-intensity focused ultrasound (HIFU) are available for reducing the volume of subcutaneous adipose tissue or cellulite. Each procedure has distinct mechanisms for stimulating apoptosis or necrosis adipose tissue. In addition to the mentioned techniques, some investigations are underway for analyzing the efficacy of other techniques such as whole body vibration (WBV) and extracorporeal shockwave therapy (ESWT)...
October 2016: International Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28103890/the-association-between-diabetes-and-dermal-microvascular-dysfunction-non-invasively-assessed-by-laser-doppler-with-local-thermal-hyperemia-a-systematic-review-with-meta-analysis
#12
REVIEW
Dagmar Fuchs, Pepijn P Dupon, Laura A Schaap, Richard Draijer
BACKGROUND/INTRODUCTION: Diabetes and cardiovascular disease develop in concert with metabolic abnormalities mirroring and causing changes in the vasculature, particularly the microcirculation. The microcirculation can be affected in different parts of the body of which the skin is the most easily accessible tissue. PURPOSE: The association between diabetes and dermal microvascular dysfunction has been investigated in observational studies. However, the strength of the association is unknown...
January 19, 2017: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/28093589/selective-bond-breaking-of-co2-in-phase-locked-two-color-intense-laser-fields-laser-field-intensity-dependence
#13
Tomoyuki Endo, Hikaru Fujise, Yuuna Kawachi, Ayaka Ishihara, Akitaka Matsuda, Mizuho Fushitani, Hirohiko Kono, Akiyoshi Hishikawa
Selective bond breaking of CO2 in phase-locked ω-2ω two-color intense laser fields (λ = 800 nm and 400 nm, total field intensity I ∼ 10(14) W cm(-2)) has been investigated by coincidence momentum imaging. The CO(+) and O(+) fragment ions produced by two-body Coulomb explosion, CO2(2+) → CO(+) + O(+), exhibit asymmetric distributions along the laser polarization direction, showing that one of the two equivalent C-O bonds is selectively broken by the laser fields. At a field intensity higher than 2 × 10(14) W cm(-2), the largest fragment asymmetry is observed when the relative phase ϕ between the ω and 2ω laser fields is ∼0 and π...
February 1, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28058160/long-term-results-of-small-incision-lenticule-extraction-in-high-myopia
#14
Yusuf Yıldırım, Cengiz Alagöz, Abdülvahit Demir, Onur Ölçücü, Mehmet Özveren, Alper Ağca, Engin Bilge Özgürhan, Ahmet Demirok
OBJECTIVES: To evaluate two-year results of small-incision lenticule extraction (SMILE) for correction of high myopia. MATERIALS AND METHODS: Forty-five eyes of 35 patients with mean spherical equivalent (SE) of -7.10±0.95 D who underwent routine SMILE by a single surgeon and were followed for at least 2 years were analyzed by retrospective chart review. SMILE was performed with a Visumax femtosecond laser (Carl Zeiss Meditec, Jena, Germany). Follow-up intervals were at 1, 6, 12, and 24 months after surgery...
October 2016: Turkish Journal of Ophthalmology
https://www.readbyqxmd.com/read/28054261/effectiveness-of-low-level-laser-therapy-on-pain-intensity-pressure-pain-threshold-and-sf-mpq-indexes-of-women-with-myofascial-pain
#15
RANDOMIZED CONTROLLED TRIAL
Laís Valencise Magri, Vinícius Almeida Carvalho, Flávia Cássia Cabral Rodrigues, César Bataglion, Christie Ramos Andrade Leite-Panissi
Women with temporomandibular disorders (TMD) frequently report pain areas in body regions. This process is associated with central sensitization phenomena, present in chronic pain. The low-level laser therapy (LLLT) has been reported as a therapeutic option for the painful TMD treatment. The aim of this study was to analyze the effect of LLLT on pain intensity (visual analogue scale, VAS), pain sensitivity in orofacial and corporal points (pressure pain threshold, PPT), and on Short Form-McGill Pain Questionnaire (SF-MPQ) indexes of women with myofascial pain (subtype of muscle TMD)...
February 2017: Lasers in Medical Science
https://www.readbyqxmd.com/read/28040973/combined-laser-ultrasonics-laser-heating-and-raman-scattering-in-diamond-anvil-cell-system
#16
Pavel V Zinin, Vitali B Prakapenka, Katherine Burgess, Shoko Odake, Nikolay Chigarev, Shiv K Sharma
We developed a multi-functional in situ measurement system under high pressure equipped with a laser ultrasonics (LU) system, Raman device, and laser heating system (LU-LH) in a diamond anvil cell (DAC). The system consists of four components: (1) a LU-DAC system (probe and pump lasers, photodetector, and oscilloscope) and DAC; (2) a fiber laser, which is designed to allow precise control of the total power in the range from 2 to 100 W by changing the diode current, for heating samples; (3) a spectrometer for measuring the temperature of the sample (using black body radiation), fluorescence spectrum (spectrum of the ruby for pressure measurement), and Raman scattering measurements inside a DAC under high pressure and high temperature (HPHT) conditions; and (4) an optical system to focus laser beams on the sample and image it in the DAC...
December 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/28027905/notochord-isolation-using-laser-capture-microdissection
#17
R G C Santegoeds, Y Yakkioui, A Jahanshahi, G Raven, J J Van Overbeeke, A Herrler, Y Temel
BACKGROUND: Chordoma are malignant tumors of the axial skeleton, which arise from remnants of the notochord. The Notochord (chorda dorsalis) is an essential embryonic structure involved in the development of the nervous system and axial skeleton. Therefore, the notochord seems to be the most biologically relevant control tissue to study chordoma in molecular biology research. Nevertheless, up to now mainly different tissues but not the notochord have been used as control for chordoma, due to difficulty of isolating notochordal tissue...
March 2017: Journal of Chemical Neuroanatomy
https://www.readbyqxmd.com/read/28005625/a-prospective-study-of-axillary-hair-reduction-in-patients-treated-with-microwave-technology
#18
MULTICENTER STUDY
Jeremy A Brauer, Julia P Neckman, Brian Zelickson, David B Vasily, Roy G Geronemus
BACKGROUND: Removing unwanted body hair is a growing trend in society today, and there are many laser-based devices for hair reduction. There are some limitations to those methods, including the lack of efficacy for lighter color hair. OBJECTIVE: The objective was to quantify hair reduction in the axillae after treatment with a noninvasive microwave energy device. MATERIALS AND METHODS: A prospective, multicenter study was performed at 3 private dermatology clinics...
April 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/27990665/clinical-assessment-of-a-new-755%C3%A2-nm-diode-laser-for-hair-removal-efficacy-safety-and-practicality-in-56-patients
#19
Josefina Royo, Javier Moreno-Moraga, Mario A Trelles
BACKGROUND AND OBJECTIVE: Recently, the first diode laser with a wavelength of 755 nm for in-motion hair removal came on the market. The objective of this study was to check its efficacy, safety, and practicality under different options for its use. METHODS: A prospective study in a heterogeneous group of 56 patients who had hair removed from various areas of their bodies using three different treatment methods. Four sessions were scheduled in all cases, with a gap of 3 months between each session...
December 19, 2016: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/27935737/low-level-laser-therapy-for-reducing-the-hip-waist-and-upper-abdomen-circumference-of-individuals-with-obesity
#20
Gregory C Roche, Steven Shanks, Robert F Jackson, Laura Jane Holsey
OBJECTIVE: To assess the effectiveness of low-level laser therapy (LLLT) for reducing hip, thigh, and abdomen circumference of individuals with body-mass index (BMI) between 30 and 40 kg/m(2). BACKGROUND: Previous studies demonstrated the effectiveness of LLLT for reducing body circumference in the hips, thighs, and abdomen of nonobese individuals with a BMI <30 kg/m(2). METHODS: In this randomized, double-blind sham-controlled study, obese, but otherwise healthy, individuals were randomized to undergo 30-min LLLT (n = 28) or sham treatments (n = 25) three times weekly for 4 weeks...
March 2017: Photomedicine and Laser Surgery
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