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https://www.readbyqxmd.com/read/29339061/dose-dependent-photochemical-photothermal-toxicity-of-indocyanine-green-based-therapy-on-three-different-cancer-cell-lines
#1
Mustafa Kemal Ruhi, Ayşe Ak Can, Murat Gülsoy
The Food and Drug Administration-approved Indocyanine Green can be used as a photosensitizer to kill cancer cells selectively. Although indocyanine green is advantageous as a photosensitizer in terms of strong absorption in the near-infrared region, indocyanine green-based cancer treatment is still not approved as a clinical method. Some reasons for this are aggregation at high concentrations, rapid clearance of the photosensitizer from the body, low singlet oxygen quantum yield, and the uncertainty concerning its action mechanism...
January 12, 2018: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/29315899/expanded-neurochemical-profile-in-the-early-stage-of-huntington-disease-using-proton-magnetic-resonance-spectroscopy
#2
Isaac M Adanyeguh, Marie-Lorraine Monin, Daisy Rinaldi, Léorah Freeman, Alexandra Durr, Stéphane Lehéricy, Pierre-Gilles Henry, Fanny Mochel
The striatum is a well-known region affected in Huntington disease (HD). However, other regions, including the visual cortex, are implicated. We have identified previously an abnormal energy response in the visual cortex of patients at an early stage of HD using 31 P magnetic resonance spectroscopy (31 P MRS). We therefore sought to further characterize these metabolic alterations with 1 H MRS using a well-validated semi-localized by adiabatic selective refocusing (semi-LASER) sequence that allows the measurement of an expanded number of neurometabolites...
January 9, 2018: NMR in Biomedicine
https://www.readbyqxmd.com/read/29261659/assessment-of-maldi-tof-mass-spectrometry-for-filariae-detection-in-aedes-aegypti-mosquitoes
#3
Djamel Tahir, Lionel Almeras, Marie Varloud, Didier Raoult, Bernard Davoust, Philippe Parola
Matrix Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry (MALDI-TOF MS) is an emerging tool for routine identification of bacteria, archaea and fungi. It has also been recently applied as an accurate approach for arthropod identification. Preliminary studies have shown that the MALDI-TOF MS was able to differentiate whether ticks and mosquitoes were infected or not with some bacteria and Plasmodium parasites, respectively. The aim of the present study was to test the efficiency of MALDI-TOF MS tool in distinguishing protein profiles between uninfected mosquitoes from specimens infected by filarioid helminths...
December 20, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29151682/anterior-segment-morphology-in-primary-angle-closure-glaucoma-using-ultrasound-biomicroscopy
#4
Tarannum Mansoori, Nagalla Balakrishna
Aim: To evaluate the configuration of the anterior chamber angle quantitatively and study the morphological changes in the eye with ultrasound biomicroscopy (UBM) in primary angle closure glaucoma (PACG) patients after laser peripheral iridotomy (LPI). Materials and methods: A total of 185 eyes of 185 PACG patients post-LPI and 126 eyes of 126 normal subjects were included in this prospective study. All subjects underwent complete ophthalmic evaluation, A-scan biometry, and UBM...
September 2017: Journal of Current Glaucoma Practice
https://www.readbyqxmd.com/read/29131947/on-line-differential-thermal-isotope-analysis-of-hydration-water-in-minerals-by-cavity-ring-down-laser-spectroscopy
#5
Thomas K Bauska, Gregory Walters, Fernando Gázquez, David Hodell
We have developed a new method for measuring the isotopic composition (δ18O and δD) of different types of bonded water (e.g., molecular water, hydroxyl) contained in hydrated minerals by coupling a thermal gravimeter (TG) and a cavity ringdown laser spectrometer (CRDS). The method involves precisely step-heating a mineral sample, allowing the separation of the different types of waters that are released at different temperatures. Simultaneously, the water vapor evolved from the mineral sample is analysed for oxygen and hydrogen isotopes by CRDS...
November 13, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/29104316/determination-of-size-sex-and-maturity-stage-of-free-swimming-catsharks-using-laser-photogrammetry
#6
REVIEW
Toby D Rogers, Giulia Cambiè, Michel J Kaiser
The lack of detailed life history (LH) information (e.g. age, growth, size at maturity, sex composition etc.) for many species of conservation importance limits the implementation of appropriate conservation measures. Typically, LH information is acquired using lethal sampling techniques, which undermines the goal of conservation. This is particularly problematic for many shark species that have low fecundity and slow growth rates. Here we tested the use of non-invasive laser photogrammetry to measure body morphometry in vivo...
2017: Marine Biology
https://www.readbyqxmd.com/read/29076886/effects-of-forced-air-warming-on-airflow-around-the-operating-table
#7
Kazuhiro Shirozu, Tetsuya Kai, Hidekazu Setoguchi, Nobuyasu Ayagaki, Sumio Hoka
BACKGROUND: Forced air warming systems are used to maintain body temperature during surgery. Benefits of forced air warming have been established, but the possibility that it may disturb the operating room environment and contribute to surgical site contamination is debated. The direction and speed of forced air warming airflow and the influence of laminar airflow in the operating room have not been reported. METHODS: In one institutional operating room, we examined changes in airflow speed and direction from a lower-body forced air warming device with sterile drapes mimicking abdominal surgery or total knee arthroplasty, and effects of laminar airflow, using a three-dimensional ultrasonic anemometer...
October 26, 2017: Anesthesiology
https://www.readbyqxmd.com/read/29068750/long-term-therapeutic-outcomes-of-photodynamic-therapy-based-or-photocoagulation-based-treatments-on-retinal-capillary-hemangioma
#8
Chuangxin Huang, Zhen Tian, Kunbei Lai, Xiaojin Zhong, Lijun Zhou, Fabao Xu, Huasheng Yang, Lin Lu, Chenjin Jin
BACKGROUND: Retinal capillary hemangioma (RCH) is a rare and refractory eye tumor. OBJECTIVE: The aim of this study was to investigate the therapeutic efficacy of two laser-based therapies for RCH, photodynamic therapy (PDT), and focal photocoagulation-based treatment. MATERIALS AND METHODS: This was a retrospective study. Eight RCH patients (10 eyes) receiving laser treatment and followed up from November 2011 to December 2016 in our hospital were selected and their medical records reviewed...
October 25, 2017: Photomedicine and Laser Surgery
https://www.readbyqxmd.com/read/29043677/using-optical-tweezers-combined-with-total-internal-reflection-microscopy-to-study-interactions-between-the-er-and-golgi-in-plant-cells
#9
Imogen Sparkes, Rhiannon R White, Benjamin Coles, Stanley W Botchway, Andy Ward
Optical tweezers have been used to trap and micromanipulate several biological specimens ranging from DNA, macromolecules, organelles to single celled organisms. Using a combination of the refraction and scattering of laser light from a focused laser beam, refractile objects are physically captured and can be moved within the surrounding media. The technique is routinely used to determine biophysical properties such as the forces exerted by motor proteins. Here, we describe how optical tweezers combined with total internal reflection fluorescence (TIRF) microscopy can be used to assess physical interactions between organelles, more specifically the ER and Golgi bodies in plant cells...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29028106/correlation-between-presence-of-primary-iris-and-cilliary-body-cysts-and-intraocular-pressure
#10
K-C Xue, D-D Hu, L Zhao, N Li, H-Y Shen
OBJECTIVE: The objective of this study was to examine the correlation between the presence of primary iris-ciliary cysts and the intraocular pressure. PATIENTS AND METHODS: Sixty patients with short-sightedness undergoing routine examination for laser vision correction in our hospital in 2003 were enrolled. Patients with known high intraocular pressure and risk of glaucoma were excluded from the study. A total of 119 eyes were examined by the Ultrasound Biomicroscope (UBM), and the presence of the primary iris-ciliary cysts was confirmed...
September 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28984677/advances-in-the-understanding-and-management-of-mucositis-during-stem-cell-transplantation
#11
Joanne M Bowen, Hannah R Wardill
PURPOSE OF REVIEW: Mucositis is a severe and common side effect of anticancer treatments, with an incidence of between 40 and 80% depending on the cytotoxic regimen used. The most profound mucositis burden is experienced during conditioning regimens for hematopoietic stem cell transplant (HSCT), where the use of highly mucotoxic agents with or without total body irradiation leads to serious damage throughout the alimentary tract. Currently, the assessment and management of both oral and gastrointestinal mucositis lack authoritative guideline, with recommendations only achieved in narrow clinical scenarios...
December 2017: Current Opinion in Supportive and Palliative Care
https://www.readbyqxmd.com/read/28965597/new-insights-into-the-metal-partitioning-in-different-microphases-of-human-gallstones
#12
Annika Parviainen, Manuel Jesús Roman-Alpiste, Claudio Marchesi, Juan Manuel Suárez-Grau, Rafael Pérez-López
Chronic metal exposure, e.g. from metal mining, may cause accumulation of metals in soft and hard tissues, and in developing biomineralizations in the human body. Gallstones are biomineralizations formed in the gallbladder which are able to trap trace elements from the bile. Laser Ablation-Inductively Coupled Plasma-Mass Spectrometry (LA-ICP-MS) was used to analyze gallstone cross-sections to trace the elemental abundances and correlate them with the principal phases constituting gallstones, namely cholesterol, Ca bilirubinate salts, Ca carbonate, and Ca phosphate...
December 2017: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/28917809/characterization-of-sodium-tripolyphosphate-and-sodium-citrate-dehydrate-residues-on-surfaces
#13
M Sadi Gurses, Can Erkey, Seda Kizilel, Alper Uzun
Sodium tripolyphosphate (STPP) and sodium citrate dihydrate (sodium citrate) are the most widely used components in detergent formulations. Here, we characterized these two components on glass surfaces to assess their possible exposures from white spots on dishwasher-washed dishes. Ultraviolet/visible near infrared spectroscopy (UV/Vis-NIR), Fourier transform infrared spectroscopy (FTIR) in the attenuated total reflectance mode (ATR-FTIR), Raman spectroscopy and laser ablation-inductively coupled plasma mass spectroscopy (LA-ICP-MS) were utilized to design calibration models for a range of STPP and sodium citrate concentrations 1-8% w/w) precipitated on glass surfaces...
January 1, 2018: Talanta
https://www.readbyqxmd.com/read/28840382/new-photobiomodulation-protocol-prevents-oral-mucositis-in-hematopoietic-stem-cell-transplantation-recipients-a-retrospective-study
#14
Camila Weissheimer, Marina Curra, Lauro J Gregianin, Liane E Daudt, Vivian P Wagner, Marco Antonio T Martins, Manoela D Martins
Oral mucositis (OM) is an adverse side effect among hematopoietic stem cell transplantation (HSCT) recipients. The objective of this retrospective study was to evaluate the preventive effect of photobiomodulation (PBM) applied three times per week versus seven times per week in patients undergoing HSCT. The risk factors related to the incidence and severity of OM were also assessed. This was a retrospective study that evaluated 99 HSCT recipients who received different PBM protocols. Group I received three sessions per week, and group II received daily treatment...
December 2017: Lasers in Medical Science
https://www.readbyqxmd.com/read/28817604/therapeutic-flexible-airway-endoscopy-of-small-children-in-a-tertiary-referral-center-11-years-experience
#15
Wen-Jue Soong, Pei-Chen Tsao, Yu-Sheng Lee, Chia-Feng Yang
OBJECTIVES: Use of therapeutic flexible airway endoscopy (TFAE) is very limited in pediatrics. We report our clinical experiences and long term outcomes of TFAE in small children from a single tertiary referral center. METHODS: This is a retrospective cohort study. Small children with their body weight no more than 5.0 kg who had received TFAE between 2005 and 2015 were enrolled. Demographic information and outcomes were reviewed and analyzed from medical charts and TFAE videos...
2017: PloS One
https://www.readbyqxmd.com/read/28790895/brain-metal-distribution-and-neuro-inflammatory-profiles-after-chronic-vanadium-administration-and-withdrawal-in-mice
#16
Oluwabusayo R Folarin, Amanda M Snyder, Douglas G Peters, Funmilayo Olopade, James R Connor, James O Olopade
Vanadium is a potentially toxic environmental pollutant and induces oxidative damage in biological systems including the central nervous system (CNS). Its deposition in brain tissue may be involved in the pathogenesis of certain neurological disorders which after prolonged exposure can culminate into more severe pathology. Most studies on vanadium neurotoxicity have been done after acute exposure but in reality some populations are exposed for a lifetime. This work was designed to ascertain neurodegenerative consequences of chronic vanadium administration and to investigate the progressive changes in the brain after withdrawal from vanadium treatment...
2017: Frontiers in Neuroanatomy
https://www.readbyqxmd.com/read/28764888/baseline-factors-affecting-changes-in-diabetic-retinopathy-severity-scale-score-after-intravitreal-aflibercept-or-laser-for-diabetic-macular-edema-post-hoc-analyses-from-vista-and-vivid
#17
Dilsher S Dhoot, Keith Baker, Namrata Saroj, Robert Vitti, Alyson J Berliner, Carola Metzig, Desmond Thompson, Rishi P Singh
PURPOSE: To evaluate whether select baseline systemic and ocular factors influence ≥2-step improvement in the Diabetic Retinopathy Severity Scale (DRSS) score at week 100 in VISTA and VIVID. DESIGN: Post hoc analysis of 2 similarly designed phase 3 trials, VISTA and VIVID. PARTICIPANTS: Total of 456 patients with center-involved diabetic macular edema (DME). METHODS: VISTA and VIVID randomized 872 DME patients to receive intravitreal aflibercept injection (IAI) 2 mg every 4 weeks (2q4), IAI 2 mg every 8 weeks after 5 monthly doses (2q8), or macular laser photocoagulation...
July 29, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28753957/the-uremic-toxin-indoxyl-sulfate-accelerates-thrombotic-response-after-vascular-injury-in-animal-models
#18
Malgorzata Karbowska, Tomasz W Kaminski, Natalia Marcinczyk, Tomasz Misztal, Tomasz Rusak, Lukasz Smyk, Dariusz Pawlak
Chronic kidney disease (CKD) patients are at high risk for thrombotic events. Indoxyl sulfate (IS) is one of the most potent uremic toxins that accumulates during CKD. Even though IS is associated with an increased risk for cardiovascular disease, its impact on thrombotic events still remains not fully understood. The purpose of the study was to evaluate the direct effect of IS on thrombotic process. We examined the impact of acute exposure to IS on thrombus development induced by electric current in Wistar rats, intravital thrombus formation after laser-induced injury in the mice endothelium, coagulation profile, clot formation dynamics, platelet aggregations, and erythrocyte osmotic resistance...
July 19, 2017: Toxins
https://www.readbyqxmd.com/read/28716090/clinical-workflow-for-mr-only-simulation-and-planning-in-prostate
#19
Neelam Tyagi, Sandra Fontenla, Michael Zelefsky, Marcia Chong-Ton, Kyle Ostergren, Niral Shah, Lizette Warner, Mo Kadbi, Jim Mechalakos, Margie Hunt
PURPOSE: To describe the details and experience of implementing a MR-only workflow in the clinic for simulation and planning of prostate cancer patients. METHODS: Forty-eight prostate cancer patients from June 2016 - Dec 2016 receiving external beam radiotherapy were scheduled to undergo MR-only simulation. MR images were acquired for contouring (T2w axial, coronal, sagittal), synthetic-CT generation (3D FFE-based) and fiducial identification (3D bFFE-based). The total acquisition time was 25 min...
July 17, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/28703288/a-comparative-proteomic-analysis-of-blood-serum-for-developmental-stages-in-pigs
#20
K Srikanth, E Lee, A Kwon, J Shin, H Chung
This study aimed to differentiate genes at developmental stages of pigs from 0 to 150 days of age, to build up a protein database and to find candidate genetic markers for growth traits. The analysis of two-dimensional electrophoresis and matrix-assisted laser-desorption/ionization mass spectrometry separated 252 protein segments. After successfully blasting the peptide sequences, the analysis confirmed 37 differentially expressed proteins that increased from birth to 150 days of age (type A), whereas the type B proteins presented the inverse pattern...
October 2017: Animal Genetics
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