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https://www.readbyqxmd.com/read/27875541/new-perspective-on-impact-of-folic-acid-supplementation-during-pregnancy-on-neurodevelopment-autism-in-the-offspring-children-a-systematic-review
#1
Yunfei Gao, Chao Sheng, Ri-Hua Xie, Wen Sun, Elizabeth Asztalos, Diane Moddemann, Lonnie Zwaigenbaum, Mark Walker, Shi Wu Wen
It has been conclusively established that folic acid supplementation prior to and during early pregnancy (up to 12 weeks of gestation) can prevent neural tube defects (NTDs). We hypothesized that folate effects may extend from neuro-structural defects to alterations in neuro-behavioural and emotional skills including autism spectrum disorders (ASDs) and other developmental disorders. The objective of this review was to comprehensively evaluate evidence on the impact of folic acid on neurodevelopment other than NTDs...
2016: PloS One
https://www.readbyqxmd.com/read/27844280/stem-cells-as-a-promising-tool-for-the-restoration-of-brain-neurovascular-unit-and-angiogenic-orientation
#2
REVIEW
Mohammad Hossein Geranmayeh, Alireza Nourazarian, Çığır Biray Avci, Reza Rahbarghazi, Mehdi Farhoudi
Establishing systemic therapeutics for neuro-inflammatory diseases is a main objective of regenerative medicine, certainly focusing on restoration of BBB dysfunction and neurovascular reconstitution. In this context, the regenerative capacity and therapeutic effects of different stem cells have been recently found to bring hopeful outcomes through trans-differentiation, paracrine interactions, and molecular cross-talk of transplanted stem cells with resident cells of blood-brain barrier. Here, we highlight some of the most recent scientific breakthroughs and discoveries by different authorities...
November 14, 2016: Molecular Neurobiology
https://www.readbyqxmd.com/read/27836715/laughter-is-the-best-medicine-the-second-city-%C3%A2-improvisation-as-an-intervention-for-parkinson-s-disease
#3
Danny Bega, Pamela Palmentera, Abby Wagner, Matt Hovde, Becca Barish, Mary J Kwasny, Tanya Simuni
BACKGROUND: Expressive therapies are increasingly incorporated into the management of Parkinson's disease (PD), although there are little objective data assessing their benefits. OBJECTIVE: Develop and study a novel community Improvisation Theater (IT) program for PD in order to improve quality of life. METHODS: A prospective, rater-blinded, modified cross-over design study of IT for PD. 22 subjects were randomized 1:1 to active-start (AS) or control-start (CS) groups, controlling for age and Hoehn and Yahr stage...
November 5, 2016: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/27824311/-unmet-needs-in-the-recognition-and-treatment-of-childhood-depression
#4
Sandor Kalmar
In spite of the fact that the good mental health is indispensable condition of the development of sound personality, in the past years the somatic and mental state of our children did not improve. The author ascertains that there are several obstacles in the recognition, treatment and prevention of child-depression that causes a serious public health problem. He stresses the neurologic, neuropsychiatric, psychopathological and diagnostic deficiencies, and the low number of Child and Youth Dispensaries. He describes the situation of Hungarian Child and Youth Dispensaries network, and states positively that today the child-psychiatric services are not able to provide optimal provision for every depressive child...
September 2016: Neuropsychopharmacologia Hungarica
https://www.readbyqxmd.com/read/27775040/reac-technology-modifies-pathological-neuroinflammation-and-motor-behaviour-in-an-alzheimer-s-disease-mouse-model
#5
Lorenzini Luca, Giuliani Alessandro, Sivilia Sandra, Baldassarro Vito Antonio, Fernandez Mercedes, Lotti Margotti Matteo, Giardino Luciana, Fontani Vania, Rinaldi Salvatore, Calzà Laura
The search for new therapeutic approaches to Alzheimer disease (AD) is a major goal in medicine and society, also due to the impressive economic and social costs of this disease. In this scenario, biotechnologies play an important role. Here, it is demonstrated that the Radio Electric Asymmetric Conveyer (REAC), an innovative technology platform for neuro- and bio-modulation, used according to the neuro-regenerative protocol (RGN-N), significantly increases astroglial reaction around the amyloid plaques in an AD mouse model, as evaluated by GFAP-immunoreactivity, and reduces microglia-associated neuroinflammation markers, as evaluated by Iba1-immunoreactivity and mRNA expression level of inflammatory cytokines TREM...
October 24, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27750470/controls-can-t-be-ignored
#6
W Frank Peacock
No abstract text is available yet for this article.
December 2, 2016: Journal of Neurotrauma
https://www.readbyqxmd.com/read/27741997/neuro-ophthalmology-in-emergency-medicine
#7
J Stephen Huff, Everett W Austin
Understanding the anatomy and physiology of the eye, the orbit, and the central connections is key to understanding neuro-ophthalmologic emergencies. Anisocoria is an important sign that requires a systematic approach to avoid misdiagnosis of serious conditions, including carotid dissection (miosis) and aneurysmal third nerve palsy (mydriasis). Ptosis may be a sign of either Horner syndrome or third nerve palsy. An explanation should be pursued for diplopia since the differential diagnosis ranges from the trivial to life-threatening causes...
November 2016: Emergency Medicine Clinics of North America
https://www.readbyqxmd.com/read/27722688/carbon-disulfide-just-toxic-or-also-bioregulatory-and-or-therapeutic
#8
Anthony W DeMartino, David F Zigler, Jon M Fukuto, Peter C Ford
The overview presented here has the goal of examining whether carbon disulfide (CS2) may play a role as an endogenously generated bioregulator and/or has therapeutic value. The neuro- and reproductive system toxicity of CS2 has been documented from its long-term use in the viscose rayon industry. CS2 is also used in the production of dithiocarbamates (DTCs), which are potent fungicides and pesticides, thus raising concern that CS2 may be an environmental toxin. However, DTCs also have recognized medicinal use in the treatment of heavy metal poisonings as well as having potency for reducing inflammation...
September 27, 2016: Chemical Society Reviews
https://www.readbyqxmd.com/read/27719625/updates-on-therapeutics-in-clinical-trials-for-spinal-cord-injuries-key-translational-applications-of-human-embryonic-stem-cells-derived-neural-progenitors
#9
Habiba Aurang Zeb, Ishaq Nasib Khan, Iqbal Munir, Wafaa Saadeldin Ramadan, Mian Afaq Ahmad, Deema Hussein, Mohammad Amjad Kamal, Saleh Al Karim
Injuries to the spinal cord often have devastating physiological impacts due to the organ's vital role in neuro-impulse communications between muscles and the brain. Spinal Cord Injuries (SCIs) have recently been estimated to affect up to 80,000 individuals per year worldwide, with most occurring following a traumatic event. Unfortunately, effective treatments standardised globally for patients with SCIs have not yet been established. For many years, inadequate understanding of the complexities of the Central and Peripheral Nervous Systems and Neurogenesis has limited progression towards effective cures...
October 4, 2016: CNS & Neurological Disorders Drug Targets
https://www.readbyqxmd.com/read/27705748/cornus-mas-l-cornelian-cherry-an-important-european-and-asian-traditional-food-and-medicine-ethnomedicine-phytochemistry-and-pharmacology-for-its-commercial-utilization-in-drug-industry
#10
REVIEW
Biswanath Dinda, Anthony M Kyriakopoulos, Subhajit Dinda, Vassilis Zoumpourlis, Nikolaos S Thomaidis, Aristea Velegraki, Charlambos Markopoulos, Manikarna Dinda
ETHNOPHARMACOLOGICAL RELEVANCE: Cornus mas L. (cornelian cherry) fruits have been used for centuries as traditional cuisine and folk medicine in various countries of Europe and Asia. In folk medicines, the fruits and other parts of the plant have been used for prevention and treatment of a wide range of diseases such as diabetes, diarrhea, gastrointestinal disorders, fevers, rheumatic pain, skin and urinary tract infections, kidney and liver diseases, sunstroke, among others. This review provides a systematic and constructive overview of ethnomedicinal uses, chemical constituents and pharmacological activities of this plant as well as future research need for its commercial utilization as nutraceutical food supplement and medicine...
December 4, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27690184/are-reprogrammed-cells-a-useful-tool-for-studying-dopamine-dysfunction-in-psychotic-disorders-a-review-of-the-current-evidence
#11
Ulrich Sauerzopf, Roberto Sacco, Gaia Novarino, Marco Niello, Ana Weidenauer, Nicole Praschak-Rieder, Harald Sitte, Matthäus Willeit
Since 2006, reprogrammed cells have increasingly been used as a biomedical research technique in addition to neuro-psychiatric methods. These rapidly evolving techniques allow for the generation of neuronal sub-populations, and have sparked interest not only in monogenetic neuro-psychiatric diseases, but also in poly-genetic and poly-etiological disorders such as schizophrenia (SCZ) and bipolar disorder (BPD). This review provides a summary of 19 publications on reprogrammed adult somatic cells derived from patients with SCZ, and 5 publications using this technique in patients with BPD...
September 30, 2016: European Journal of Neuroscience
https://www.readbyqxmd.com/read/27685355/phospholipid-complexation-of-nmitli118rt-way-to-a-prudent-therapeutic-approach-for-beneficial-outcomes-in-ischemic-stroke-in-rats
#12
Hafsa Ahmad, Abhishek Arya, Satish Agrawal, Sheeba Saji Samuel, Sandeep Kumar Singh, Guru Raghavendra Valicherla, Neelam Sangwan, Kalyan Mitra, Jiaur R Gayen, Sarwesh Paliwal, Rakesh Shukla, Anil Kumar Dwivedi
Withania somnifera Dunal (Solanaceae) known as Ashwagandha, a popular plant of Indian origin is known to possess tremedous medicinal potential, often used as anti-inflammatory, anti-platelet, antihypertensive, hypoglycemic, hypolipidemic and adaptogenic candidate. Some of its chemotypes developed by CSIR, India includes NMITLI-101, NMITLI-118, NMITLI-128. In this study the investigators have attempted development of a phytosomal complex of NMITLI118RT + (standardized ethanolic extract of a new chemotype of W...
November 2016: Drug Delivery
https://www.readbyqxmd.com/read/27646569/a-four-part-working-bibliography-of-neuroethics-part-3-second-tradition-neuroethics-ethical-issues-in-neuroscience
#13
EDITORIAL
Amanda Martin, Kira Becker, Martina Darragh, James Giordano
BACKGROUND: Neuroethics describes several interdisciplinary topics exploring the application and implications of engaging neuroscience in societal contexts. To explore this topic, we present Part 3 of a four-part bibliography of neuroethics' literature focusing on the "ethics of neuroscience." METHODS: To complete a systematic survey of the neuroethics literature, 19 databases and 4 individual open-access journals were employed. Searches were conducted using the indexing language of the U...
September 19, 2016: Philosophy, Ethics, and Humanities in Medicine: PEHM
https://www.readbyqxmd.com/read/27644129/differentiation-of-spermatogonia-stem-cells-into-functional-mature-neurons-characterized-with-differential-gene-expression
#14
Maryam Nazm Bojnordi, Hossein Azizi, Thomas Skutella, Mansoureh Movahedin, Fereshteh Pourabdolhossein, Amir Shojaei, Hatef Ghasemi Hamidabadi
Transplantation of embryonic stem cells (ESCs) is a promising therapeutic approach for the treatment of neurodegenerative diseases. However, ESCs are not usable clinically due to immunological and ethical limitations. The identification of an alternative safe cell source opens novel options via autologous transplantation in neuro-regeneration circumventing these problems. Here, we examined the neurogenic capacity of embryonic stem-like cells (ES-like cells) derived from the testis using neural growth factor inducers and utilized them to generate functional mature neurons...
September 19, 2016: Molecular Neurobiology
https://www.readbyqxmd.com/read/27556225/technique-of-spinal-cord-compression-induced-by-inflation-of-epidural-balloon-catheter-in-rabbits-oryctologus-cuniculus-efficient-and-easy-to-use-model
#15
Antonio F B DA Fonseca, Jussara P Scheffer, Barbara P Coelho, Graciane Aiello, Arthur G Guimarães, Carlos R B Gama, Victor Vescovini, Paula G A Cabral, André L A Oliveira
The most common cause of spinal cord injury are high impact trauma, which often result in some motor impairment, sensory or autonomic a greater or lesser extent in the distal areas the level of trauma. In terms of survival and complications due to sequelae, veterinary patients have a poor prognosis unfavorable. Therefore justified the study of experimental models of spinal cord injury production that could provide more support to research potential treatments for spinal cord injuries in medicine and veterinary medicine...
September 2016: Anais da Academia Brasileira de Ciências
https://www.readbyqxmd.com/read/27523637/co-evolution-of-peer-reviewed-literature-and-clinical-practice-in-high-grade-glioma-resection
#16
Brian R Hirshman, Laurie A Jones, Kate T Carroll, Jessica A Tang, James A Proudfoot, Kathleen M Carley, Bob S Carter, Clark C Chen
BACKGROUND: The paradigm of evidence-based medicine dictates that clinical practice should reflect the shifting landscape of the peer-reviewed literature. Here, we examine the extent to which this premise is fulfilled as it pertains to the surgical resection of high-grade gliomas (HGGs). OBJECTIVE: We assess trends in published literature regarding HGG survival after resection in conjunction with clinical practice patterns of HGG resection. METHODS: We performed a comprehensive PubMed search to identify articles that examined whether gross total resection (GTR) improves HGG survival...
August 11, 2016: World Neurosurgery
https://www.readbyqxmd.com/read/27521025/investigation-of-the-protective-effect-of-paeonia-lactiflora-on-semen-strychni-induced-neurotoxicity-based-on-monitoring-nine-potential-neurotoxicity-biomarkers-in-rat-serum-and-brain-tissue
#17
Huiyan Shi, Chenzhi Hou, Liqiang Gu, Hang Xing, Meiyu Zhang, Longshan Zhao, Kaishun Bi, Xiaohui Chen
Semen Strychni has been widely used as a traditional Chinese herb medicine, but its clinical use was limited for its potential neurotoxicity and nephrotoxicity. This study aimed to investigate S. Strychni-induced neurotoxicity and the neuro-protective effect of Paeonia lactiflora based on monitoring nine potential neurotoxicity biomarkers in rat serum and brain tissue. A sensitive liquid chromatography-tandem mass spectrometry method was developed and validated to monitor serotonin, tryptophan, dopamine, tyrosine and glutamate in serum and five brain regions (prefrontal cortex, hippocampus, striatum, cerebellum and hypothalamus)...
August 13, 2016: Metabolic Brain Disease
https://www.readbyqxmd.com/read/27510612/pediatrics-in-21-st-century-and-beyond
#18
Meharban Singh
Pediatrics is a dynamic discipline and there is awareness and hope for actualizing outstanding achievements in the field of child health in 21(st) century and beyond. Improved lifestyle and quality of children's health is likely to reduce the burden of adult diseases and enhance longevity because seeds of most adult diseases are sown in childhood. Identification and decoding of human genome is expected to revolutionize the practice of pediatrics. The day is not far off when a patient will walk into doctor's chamber with an electronic or digital health history on a CD or palmtop and a decoded genomic constitution...
November 2016: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/27509070/defining-glioblastoma-resectability-through-the-wisdom-of-the-crowd-a-proof-of-principle-study
#19
Adam M Sonabend, Brad E Zacharia, Michael B Cloney, Aarón Sonabend, Christopher Showers, Victoria Ebiana, Matthew Nazarian, Kristin R Swanson, Anne Baldock, Henry Brem, Jeffrey N Bruce, William Butler, Daniel P Cahill, Bob Carter, Daniel A Orringer, David W Roberts, Oren Sagher, Nader Sanai, Theodore H Schwartz, Daniel L Silbergeld, Michael B Sisti, Reid C Thompson, Allen E Waziri, Guy McKhann
BACKGROUND: Extent of resection (EOR) correlates with glioblastoma outcomes. Resectability and EOR depend on anatomical, clinical, and surgeon factors. Resectability likely influences outcome in and of itself, but an accurate measurement of resectability remains elusive. An understanding of resectability and the factors that influence it may provide a means to control a confounder in clinical trials and provide reference for decision making. OBJECTIVE: To provide proof of concept of the use of the collective wisdom of experienced brain tumor surgeons in assessing glioblastoma resectability...
August 4, 2016: Neurosurgery
https://www.readbyqxmd.com/read/27487266/network-ethnopharmacological-evaluation-of-the-immunomodulatory-activity-of-withania-somnifera
#20
Uma Chandran, Bhushan Patwardhan
ETHNOPHARMACOLOGICAL RELEVANCE: Withania somnifera (L.) Dunal (Ashwagandha, WS) is one of the extensively explored Ayurvedic botanicals. Several properties including immunomodulation, anti-cancer and neuro-protection of the botanical have been reported. Even though, in indigenous medicine, WS is well known for its immunomodulatory activity, the molecular mechanism of immunomodulation has not been elucidated. AIM OF THE STUDY: This study aimed the evaluation of the immunomodulatory effect of WS using network ethnopharmacology technique to elucidate the in silico molecular mechanism...
July 31, 2016: Journal of Ethnopharmacology
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