keyword
https://read.qxmd.com/read/38498739/repetitive-transcranial-alternating-current-stimulation-to-improve-working-memory-an-eeg-fnirs-study
#21
JOURNAL ARTICLE
Dalin Yang, Min-Kyoung Kang, Guanghao Huang, Adam T Eggebrecht, Keum-Shik Hong
Transcranial electrical stimulation has demonstrated the potential to enhance cognitive functions such as working memory, learning capacity, and attentional allocation. Recently, it was shown that periodic stimulation within a specific duration could augment the human brain's neuroplasticity. This study investigates the effects of repetitive transcranial alternating current stimulation (tACS; 1 mA, 5 Hz, 2 min duration) on cognitive function, functional connectivity, and topographic changes using both electroencephalography (EEG) and functional near-infrared spectroscopy (fNIRS)...
March 18, 2024: IEEE Transactions on Neural Systems and Rehabilitation Engineering
https://read.qxmd.com/read/38494274/paraneoplastic-encephalitis
#22
REVIEW
Silvia Casagrande, Luigi Zuliani, Wolfgang Grisold
The first reports of encephalitis associated with cancer date to the 1960s and were characterized by clinical and pathologic involvement of limbic areas. This specific association was called limbic encephalitis (LE). The subsequent discovery of several "onconeural" antibodies (Abs), i.e., Abs targeting an antigen shared by neurons and tumor cells, supported the hypothesis of an autoimmune paraneoplastic etiology of LE and other forms of rapidly progressive encephalopathy. Over the past 20 years, similar clinical pictures with different clinical courses have been described in association with novel Abs-binding neuronal membrane proteins and proved to be pathogenic...
2024: Handbook of Clinical Neurology
https://read.qxmd.com/read/38492275/regoma-oss-a-large-italian-multicenter-prospective-observational-study-evaluating-the-efficacy-and-safety-of-regorafenib-in-patients-with-recurrent-glioblastoma
#23
JOURNAL ARTICLE
M Caccese, I Desideri, V Villani, M Simonelli, M Buglione, S Chiesa, E Franceschi, P Gaviani, I Stasi, C Caserta, S Brugnara, I Lolli, E Bennicelli, P Bini, A S Cuccu, S Scoccianti, M Padovan, S Gori, A Bonetti, P Giordano, A Pellerino, F Gregucci, N Riva, S Cinieri, V Internò, M Santoni, G Pernice, C Dealis, L Stievano, F Paiar, G Magni, G L De Salvo, V Zagonel, G Lombardi
BACKGROUND: In the randomized phase II REGOMA trial, regorafenib showed promising activity in patients with recurrent glioblastoma. We conducted a large, multicenter, prospective, observational study to confirm the REGOMA data in a real-world setting. PATIENTS AND METHODS: The major inclusion criteria were histologically confirmed diagnosis of glioblastoma according to the World Health Organization (WHO) 2016 classification and relapse after radiotherapy with concurrent/adjuvant temozolomide treatment, good performance status [Eastern Cooperative Oncology Group performance status (ECOG PS 0-1)] and good liver function...
March 15, 2024: ESMO Open
https://read.qxmd.com/read/38490261/impacts-of-environmental-tobacco-smoke-on-the-onset-and-progression-of-multiple-sclerosis-a-systematic-review
#24
JOURNAL ARTICLE
Marco Antônio Machado Schlindwein, Marcelo Henrique de Moura Campos, Leticia Caroline Breis, Beatriz Sordi Chara, Clara Sasse Scherer, Vitória Augusta Piva Caminski, André Matta, Marcus Vinicius Magno Gonçalves
BACKGROUND:  Unlike cigarette smoking, environmental tobacco smoke (ETS) has not been as well described as an environmental risk for Multiple sclerosis (MS) nor as a risk factor for disease progression. OBJECTIVE:  We systematically reviewed the association between ETS and the risk of onset and/or progression of MS. METHODS:  We systematically screened MedLine/PubMed, Science Direct, LILACs, and SciELO searching for publications between January 1st, 2010, and July 5, 2021, with the following keywords: "multiple sclerosis and smoking"; "multiple sclerosis and passive smoking"; "multiple sclerosis and secondhand smoking"...
March 2024: Arquivos de Neuro-psiquiatria
https://read.qxmd.com/read/38487358/the-impact-of-valsalva-manoeuvres-and-exercise-on-intracranial-pressure-and-cerebrovascular-dynamics-in-idiopathic-intracranial-hypertension
#25
JOURNAL ARTICLE
Andreas Yiangou, Samuel R C Weaver, Mark Thaller, James L Mitchell, Hannah S Lyons, Georgios Tsermoulas, Susan P Mollan, Samuel J E Lucas, Alexandra J Sinclair
Idiopathic intracranial hypertension (IIH) is a disease characterised by elevated intracranial pressure (ICP). The impact of straining and exercise on ICP regulation is poorly understood yet clinically relevant to IIH patient care. We sought to investigate the impact of Valsalva manoeuvres (VMs) and exercise on ICP and cerebrovascular haemodynamics in IIH. People with IIH were prospectively enrolled and had an intraparenchymal telemetric ICP sensor inserted. Three participants (age [mean ± standard deviation]: 40...
2024: Neuro-ophthalmology
https://read.qxmd.com/read/38486856/advancements-in-chimeric-antigen-receptor-expressing-t-cell-therapy-for-glioblastoma-multiforme-literature-review-and-future-directions
#26
REVIEW
Michael Goutnik, Alexandria Iakovidis, Megan E H Still, Rachel S F Moor, Kaitlyn Melnick, Sandra Yan, Muhammad Abbas, Jianping Huang, Ashley P Ghiaseddin
Glioblastoma multiforme (GBM) is an aggressive cancer that has been difficult to treat and often requires multimodal therapy consisting of surgery, radiotherapy, and chemotherapy. Chimeric antigen receptor-expressing (CAR-T) cells have been efficacious in treating hematological malignancies, resulting in several FDA-approved therapies. CAR-T cells have been more recently studied for the treatment of GBM, with some promising preclinical and clinical results. The purpose of this literature review is to highlight the commonly targeted antigens, results of clinical trials, novel modifications, and potential solutions for challenges that exist for CAR-T cells to become more widely implemented and effective in eradicating GBM...
2024: Neuro-oncology advances
https://read.qxmd.com/read/38485255/concordance-rate-between-oligoclonal-bands-and-the-kappa-index-in-patients-with-suspected-multiple-sclerosis-ms
#27
JOURNAL ARTICLE
Renan Barros Domingues, Márcio Vega Dos Santos, Daiane Salomão, Carlos Senne
BACKGROUND:  Oligoclonal bands (OCBs) and Kappa free light chains (FLCs) in the cerebrospinal fluid (CSF) are sensitive markers of intrathecal immunoglobulin (Ig)G synthesis in patients with multiple sclerosis. OBJECTIVE:  To evaluate the concordance rate between OCBCs and the Kappa index (KI) in patients with suspected multiple sclerosis (MS). METHODS:  Patients with suspected MS were referred to a specialized CSF laboratory as part of their diagnostic investigation...
March 2024: Arquivos de Neuro-psiquiatria
https://read.qxmd.com/read/38484928/heterogeneity-in-functional-connectivity-dimensional-predictors-of-individual-variability-during-rest-and-task-fmri-in-psychosis
#28
JOURNAL ARTICLE
Maria T Secara, Lindsay D Oliver, Julia Gallucci, Erin W Dickie, George Foussias, James Gold, Anil K Malhotra, Robert W Buchanan, Aristotle N Voineskos, Colin Hawco
BACKGROUND: Individuals with schizophrenia spectrum disorders (SSD) often demonstrate cognitive impairments, associated with poor functional outcomes. While neurobiological heterogeneity has posed challenges when examining social cognition in SSD, it provides a unique opportunity to explore brain-behavior relationships. The aim of this study was to investigate the relationship between individual variability in functional connectivity during resting state and the performance of a social task and social and non-social cognition in a large sample of controls and individuals diagnosed with SSD...
March 12, 2024: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://read.qxmd.com/read/38484017/insider-interpretable-sparse-matrix-decomposition-for-rna-expression-data-analysis
#29
JOURNAL ARTICLE
Kai Zhao, Sen Huang, Cuichan Lin, Pak Chung Sham, Hon-Cheong So, Zhixiang Lin
RNA sequencing (RNA-Seq) is widely used to capture transcriptome dynamics across tissues, biological entities, and conditions. Currently, few or no methods can handle multiple biological variables (e.g., tissues/ phenotypes) and their interactions simultaneously, while also achieving dimension reduction (DR). We propose INSIDER, a general and flexible statistical framework based on matrix factorization, which is freely available at https://github.com/kai0511/insider. INSIDER decomposes variation from different biological variables and their interactions into a shared low-rank latent space...
March 14, 2024: PLoS Genetics
https://read.qxmd.com/read/38481999/systemic-and-local-immunosuppression-in-glioblastoma-and-its-prognostic-significance
#30
REVIEW
Aleksei A Stepanenko, Anastasiia O Sosnovtseva, Marat P Valikhov, Anastasia A Chernysheva, Olga V Abramova, Konstantin A Pavlov, Vladimir P Chekhonin
The effectiveness of tumor therapy, especially immunotherapy and oncolytic virotherapy, critically depends on the activity of the host immune cells. However, various local and systemic mechanisms of immunosuppression operate in cancer patients. Tumor-associated immunosuppression involves deregulation of many components of immunity, including a decrease in the number of T lymphocytes (lymphopenia), an increase in the levels or ratios of circulating and tumor-infiltrating immunosuppressive subsets [e.g., macrophages, microglia, myeloid-derived suppressor cells (MDSCs), and regulatory T cells (Tregs)], as well as defective functions of subsets of antigen-presenting, helper and effector immune cell due to altered expression of various soluble and membrane proteins (receptors, costimulatory molecules, and cytokines)...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38476931/unraveling-the-relations-between-post-traumatic-stress-symptoms-neurocognitive-functioning-and-limbic-white-matter-in-pediatric-brain-tumor-patients
#31
JOURNAL ARTICLE
Anne E M Leenders, Eva Kremer-Hooft van Huijsduijnen, Bruno Robalo, Rosa van Male, Alberto De Luca, Rachèl Kemps, Eelco Hoving, Maarten H Lequin, Martha A Grootenhuis, Marita Partanen
BACKGROUND: Pediatric brain tumor patients are at risk of developing neurocognitive impairments and associated white matter alterations. In other populations, post-traumatic stress symptoms (PTSS) impact cognition and white matter. This study aims to investigate the effect of PTSS on neurocognitive functioning and limbic white matter in pediatric brain tumor patients. METHODS: Sixty-six patients (6-16 years) completed neuropsychological assessment and brain MRI (1-year post-diagnosis) and parents completed PTSS proxy questionnaires (CRIES-13; 1-3 months and 1-year post-diagnosis)...
2024: Neuro-oncology advances
https://read.qxmd.com/read/38474510/antimicrobial-activity-of-syzygium-aromaticum-essential-oil-in-human-health-treatment
#32
REVIEW
Valentina Maggini, Giulia Semenzato, Eugenia Gallo, Alessia Nunziata, Renato Fani, Fabio Firenzuoli
The use of natural compounds to prevent and treat infective diseases is increasing its importance, especially in the case of multidrug-resistant (MDR) microorganisms-mediated infections. The drug resistance phenomenon is today a global problem, so it is important to have available substances able to counteract MDR infections. Syzygium aromaticum (L.) Merr. & L.M. Perry (commonly called clove) is a spice characterized by several biological properties. Clove essential oil (EO) consists of numerous active molecules, being eugenol as the principal component; however, other compounds that synergize with each other are responsible for the biological properties of the EO...
February 25, 2024: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/38470723/zirconia-hybrid-dental-implants-influence-the-biological-properties-of-neural-crest-derived-mesenchymal-stromal-cells
#33
JOURNAL ARTICLE
Nadia Tagliaferri, Alessandra Pisciotta, Giulia Orlandi, Giulia Bertani, Rosanna Di Tinco, Laura Bertoni, Paola Sena, Alice Lunghi, Michele Bianchi, Federica Veneri, Pierantonio Bellini, Jessika Bertacchini, Enrico Conserva, Ugo Consolo, Gianluca Carnevale
Dental implants are regularly employed in tooth replacement, the good clinical outcome of which is strictly correlated to the choice of an appropriate implant biomaterial. Titanium-based implants are considered the gold standard for rehabilitation of edentulous spaces. However, the insurgence of allergic reactions, cellular sensitization and low integration with dental and gingival tissues lead to poor osseointegration, affecting the implant stability in the bone and favoring infections and inflammatory processes in the peri-implant space...
February 20, 2024: Nanomaterials
https://read.qxmd.com/read/38470098/non-acute-exposure-of-neonicotinoids-health-risk-assessment-and-evidence-integration-a-systematic-review
#34
REVIEW
Imen Benchikh, Kaddour Ziani, Antonio Gonzalez Mateos, Boumediène Méghit Khaled
Neonicotinoid pesticides are utilized against an extensive range of insects. A growing body of evidence supports that these neuro-active insecticides are classified as toxicants in invertebrates. However, there is limited published data regarding their toxicity in vertebrates and mammals. the current systematic review is focused on the up-to-date knowledge available for several neonicotinoid pesticides and their non-acute toxicity on rodents and human physiology. Oral lethal dose 50 (LD50 ) of seven neonicotinoids (i...
March 12, 2024: Critical Reviews in Toxicology
https://read.qxmd.com/read/38469828/a-framework-for-the-analysis-of-skin-sores-disease-using-evolutionary-intelligent-computing-approach
#35
JOURNAL ARTICLE
Muhammad Shoaib, Rafia Tabassum, Kottakkaran Sooppy Nisar, Muhammad Asif Zahoor Raja
The most common and contagious bacterial skin disease i.e. skin sores (impetigo) mostly affects newborns and young children. On the face, particularly around the mouth and nose area, as well as on the hands and feet, it typically manifests as reddish sores. In this study, a neuro-evolutionary global algorithm is introduced to solve the dynamics of nonlinear skin sores disease model (SSDM) with the help of an artificial neural network. The global genetic algorithm is integrated with local sequential quadratic programming (GA-LSQP) to obtain the optimal solution for the proposed model...
March 12, 2024: Computer Methods in Biomechanics and Biomedical Engineering
https://read.qxmd.com/read/38468051/computational-fractal-based-analysis-of-brain-tumor-microvascular-networks
#36
JOURNAL ARTICLE
Antonio Di Ieva, Omar S Al-Kadi
Brain parenchyma microvasculature is set in disarray in the presence of tumors, and malignant brain tumors are among the most vascularized neoplasms in humans. As microvessels can be easily identified in histologic specimens, quantification of microvascularity can be used alone or in combination with other histological features to increase the understanding of the dynamic behavior, diagnosis, and prognosis of brain tumors. Different brain tumors, and even subtypes of the same tumor, show specific microvascular patterns, as a kind of "microvascular fingerprint," which is particular to each histotype...
2024: Advances in Neurobiology
https://read.qxmd.com/read/38468037/fractal-analysis-in-clinical-neurosciences-an-overview
#37
JOURNAL ARTICLE
Antonio Di Ieva
Over the last years, fractals have entered into the realms of clinical neurosciences. The whole brain and its components (i.e., neurons and astrocytes) have been studied as fractal objects, and even more relevant, the fractal-based quantification of the geometrical complexity of histopathological and neuroradiological images as well as neurophysiopathological time series has suggested the existence of a gradient in the pattern representation of neurological diseases. Computational fractal-based parameters have been suggested as potential diagnostic and prognostic biomarkers in different brain diseases, including brain tumors, neurodegeneration, epilepsy, demyelinating diseases, cerebrovascular malformations, and psychiatric disorders as well...
2024: Advances in Neurobiology
https://read.qxmd.com/read/38467394/frederic-lewy-how-the-two-world-wars-changed-his-life-work-and-name
#38
JOURNAL ARTICLE
Patrick Emanuell Mesquita Sousa-Santos, Pedro Machry Pozzobon, Igor de Lima E Teixeira
In 1912, Friedrich Lewy described the inclusion bodies present in Parkinson disease and in Lewy body dementia. Throughout his life, Lewy fought in two wars - on opposite sides. He was born in Berlin in a Jewish family, and served in the German Army in World War I. In the following years, on many occasions he had to change his line of research due to Nazi persecution. Lewy became a naturalized American, changed his name to Frederic Henry Lewey, and served in the US Army as a lieutenant colonel. Lewy died in 1950 and never used the famous eponym in his papers...
March 2024: Arquivos de Neuro-psiquiatria
https://read.qxmd.com/read/38467393/cerebral-palsy-and-sleep-nonpharmacological-treatment-and-impact-on-the-life-of-caregivers-an-integrative-review
#39
REVIEW
Marcela Fischer de Almeida, Suzane Mello, Marise Bueno Zonta, Ana Chrystina Crippa
BACKGROUND:  Children with cerebral palsy have a higher prevalence of sleep disorders, with numerous factors associated with a negative impact on the quality of life of caregivers. OBJECTIVE:  To identify factors related to sleep disorders, nonpharmacological treatment, and the impact on the lives of caregivers. METHODS:  The present literature review was carried out in the Latin American and Caribbean Center on Health Sciences Information (BIREME), the Cochrane Library, Scopus, PubMed, the Cumulative Index to Nursing and Allied Health Literature (CINAHL), PsycInfo, WorldCat, Web of Science, Latin American Literature on Health Sciences (LILACS), and Excerpta Medica Database (EMBASE), with the descriptors sleep, child, cerebral palsy, parents , and nursing ...
March 2024: Arquivos de Neuro-psiquiatria
https://read.qxmd.com/read/38466087/challenges-limitations-and-pitfalls-of-pet-and-advanced-mri-in-patients-with-brain-tumors-a-report-of-the-pet-rano-group
#40
JOURNAL ARTICLE
Norbert Galldiks, Timothy J Kaufmann, Philipp Vollmuth, Philipp Lohmann, Marion Smits, Michael C Veronesi, Karl-Josef Langen, Roberta Rudá, Nathalie L Albert, Elke Hattingen, Ian Law, Markus Hutterer, Riccardo Soffietti, Michael A Vogelbaum, Patrick Y Wen, Michael Weller, Joerg-Christian Tonn
Brain tumor diagnostics have significantly evolved with the use of PET and advanced MRI techniques. In addition to anatomical MRI, these modalities may provide valuable information for several clinical applications such as differential diagnosis, delineation of tumor extent, prognostication, differentiation between tumor relapse and treatment-related changes, and the evaluation of response to anticancer therapy. In particular, joint recommendations of the RANO group, the EANO, and major European and American Nuclear Medicine societies highlighted that the additional clinical value of radiolabeled amino acids compared to anatomical MRI alone is outstanding and that its widespread clinical use should be supported...
March 11, 2024: Neuro-oncology
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