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https://www.readbyqxmd.com/read/28430558/lower-esophageal-sphincter-augmentation-for-gastroesophageal-reflux-disease-the-safety-of-a-modern-implant
#1
C Daniel Smith, Robert A Ganz, John C Lipham, Reginald C Bell, David W Rattner
INTRODUCTION: Use of the magnetic sphincter augmentation device (MSAD) for gastroesophageal reflux disease (GERD) is increasing. As this innovative treatment for GERD gains widespread use and adoption, an assessment of its safety since U.S. market introduction is presented. METHODS: Events were collected from the Manufacturer and User Facility Device Experience (MAUDE) database, which reports events submitted to the Food and Drug Administration (FDA) of suspected device-associated deaths, serious injuries, and malfunctions...
April 21, 2017: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://www.readbyqxmd.com/read/28421759/is-the-accuracy-of-density-functional-theory-for-atomization-energies-and-densities-in-bonding-regions-correlated
#2
Kurt R Brorsen, Yang Yang, Michael V Pak, Sharon Hammes-Schiffer
The development of approximate exchange-correlation functionals is critical for modern density functional theory. A recent analysis of atomic systems suggested that some modern functionals are straying from the path toward the exact functional because electron densities are becoming less accurate while energies are becoming more accurate since the year 2000. To investigate this trend for more chemically relevant systems, the electron densities in the bonding regions and the atomization energies are analyzed for a series of diatomic molecules with 90 different functionals...
April 19, 2017: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/28421100/integrated-approach-of-agri-nanotechnology-challenges-and-future-trends
#3
REVIEW
Sandhya Mishra, Chetan Keswani, P C Abhilash, Leonardo F Fraceto, Harikesh Bahadur Singh
Nanotechnology representing a new frontier in modern agriculture is anticipated to become a major thrust in near future by offering potential applications. This integrating approach, i.e., agri-nanotechnology has great potential to cope with global challenges of food production/security, sustainability and climate change. However, despite the potential benefits of nanotechnology in agriculture so far, their relevance has not reached up to the field conditions. The elevating concerns about fate, transport, bioavailability, nanoparticles toxicity and inappropriateness of regulatory framework limit the complete acceptance and inclination to adopt nanotechnologies in agricultural sector...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28419523/multiple-imputation-to-evaluate-the-impact-of-an-assay-change-in-national-surveys
#4
Maya Sternberg
National health surveys, such as the National Health and Nutrition Examination Survey, are used to monitor trends of nutritional biomarkers. These surveys try to maintain the same biomarker assay over time, but there are a variety of reasons why the assay may change. In these cases, it is important to evaluate the potential impact of a change so that any observed fluctuations in concentrations over time are not confounded by changes in the assay. To this end, a subset of stored specimens previously analyzed with the old assay is retested using the new assay...
April 16, 2017: Statistics in Medicine
https://www.readbyqxmd.com/read/28411696/first-10-month-results-of-the-vascular-quality-initiative-varicose-vein-registry
#5
Andrea T Obi, Danielle C Sutzko, Jose I Almeida, Lowell Kabnick, Jack L Cronenwett, Nicholas H Osborne, Brajesh K Lal, Thomas W Wakefield
OBJECTIVE: The Vascular Quality Initiative Varicose Vein Registry (VQI VVR) represents a new Patient Safety Organization database launched in January 2015 as a collaborative effort between the American Venous Forum and the Society for Vascular Surgery. This study was undertaken to identify real-world trends among treatment choices and outcomes of varicose vein patients. METHODS: Registry data prospectively captured anatomic, procedural, and outcome data for patients with C2 or more severe disease undergoing intervention for venous varicosities from January to November 2015...
May 2017: Journal of Vascular Surgery. Venous and Lymphatic Disorders
https://www.readbyqxmd.com/read/28410855/methods-of-albumin-estimation-in-clinical-biochemistry-past-present-and-future
#6
REVIEW
Deepak Kumar, Dibyajyoti Banerjee
Estimation of serum and urinary albumin is routinely performed in clinical biochemistry laboratories. In the past, precipitation-based methods were popular for estimation of human serum albumin (HSA). Currently, dye-binding or immunochemical methods are widely practiced. Each of these methods has its limitations. Research endeavors to overcome such limitations are on-going. The current trends in methodological aspects of albumin estimation guiding the field have not been reviewed. Therefore, it is the need of the hour to review several aspects of albumin estimation...
April 11, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/28408854/control-of-confounding-in-the-analysis-phase-an-overview-for-clinicians
#7
Johnny Kahlert, Sigrid Bjerge Gribsholt, Henrik Gammelager, Olaf M Dekkers, George Luta
In observational studies, control of confounding can be done in the design and analysis phases. Using examples from large health care database studies, this article provides the clinicians with an overview of standard methods in the analysis phase, such as stratification, standardization, multivariable regression analysis and propensity score (PS) methods, together with the more advanced high-dimensional propensity score (HD-PS) method. We describe the progression from simple stratification confined to the inclusion of a few potential confounders to complex modeling procedures such as the HD-PS approach by which hundreds of potential confounders are extracted from large health care databases...
2017: Clinical Epidemiology
https://www.readbyqxmd.com/read/28401032/modern-trends-in-lipomodeling
#8
REVIEW
Ahmed Hassan El-Sabbagh
Lipomodeling is the process of relocating autologous fat to change the shape, volume, consistency, and profile of tissues, with the aim of reconstructing, rejuvenating, and regenerating body features. There have been several important advancements in lipomodeling procedures during the last thirty years. Four clinical steps are important for the success of engraftment: fat harvesting, fat processing, fat reinjection, and preconditioning of the recipient site. With the discovery of adipose derived stem cells and dedifferentiated cells, fat cells become a major tool of regenerative medicine...
2017: GMS Interdisciplinary Plastic and Reconstructive Surgery DGPW
https://www.readbyqxmd.com/read/28393866/long-term-trends-in-the-intensity-and-relative-toxicity-of-herbicide-use
#9
Andrew R Kniss
Herbicide use is among the most criticized aspects of modern farming, especially as it relates to genetically engineered (GE) crops. Many previous analyses have used flawed metrics to evaluate herbicide intensity and toxicity trends. Here, I show that herbicide use intensity increased over the last 25 years in maize, cotton, rice and wheat. Although GE crops have been previously implicated in increasing herbicide use, herbicide increases were more rapid in non-GE crops. Even as herbicide use increased, chronic toxicity associated with herbicide use decreased in two out of six crops, while acute toxicity decreased in four out of six crops...
April 10, 2017: Nature Communications
https://www.readbyqxmd.com/read/28391001/three-dimensional-mitral-valve-morphology-and-age-related-trends-children-and-young-adults-with-structurally-normal-hearts-using-transthoracic-echocardiography
#10
Matthew A Jolley, Sunil J Ghelani, Adi Adar, David M Harrild
BACKGROUND: The mitral valve has a complex three-dimensional (3D) morphology that is incompletely described by two-dimensional echocardiography (echo). Three-dimensional echo provides a more robust tool to analyze the mitral valve. The shape of the mitral annulus and leaflets, and differences with age, have not been described by 3D echo in normal children. Our objective was to characterize and quantify the 3D mitral valve morphology in children with normal transthoracic echocardiograms over a broad spectrum of age and to identify differences in valve shape with age...
April 6, 2017: Journal of the American Society of Echocardiography
https://www.readbyqxmd.com/read/28390104/historical-and-projected-trends-in-landscape-drivers-affecting-carbon-dynamics-in-alaska
#11
Neal J Pastick, Paul Duffy, Hélène Genet, T Scott Rupp, Bruce K Wylie, Kristofer D Johnson, M Torre Jorgenson, Norman Bliss, A David McGuire, Elchin E Jafarov, Joseph F Knight
Modern climate change in Alaska has resulted in widespread thawing of permafrost, increased fire activity, and extensive changes in vegetation characteristics that have significant consequences for socio-ecological systems. Despite observations of the heightened sensitivity of these systems to change, there has not been a comprehensive assessment of factors that drive ecosystem changes throughout Alaska. Here we present research that improves our understanding of the main drivers of the spatiotemporal patterns of carbon dynamics using in situ observations, remote sensing data, and an array of modeling techniques...
April 8, 2017: Ecological Applications: a Publication of the Ecological Society of America
https://www.readbyqxmd.com/read/28361271/the-development-of-translational-biomarkers-as-a-tool-for-improving-the-understanding-diagnosis-and-treatment-of-chronic-neuropathic-pain
#12
David A Buckley, Elaine M Jennings, Nikita N Burke, Michelle Roche, Veronica McInerney, Jonathan D Wren, David P Finn, Patrick C McHugh
Chronic neuropathic pain (CNP) is one of the most significant unmet clinical needs in modern medicine. Alongside the lack of effective treatments, there is a great deficit in the availability of objective diagnostic methods to reliably facilitate an accurate diagnosis. We therefore aimed to determine the feasibility of a simple diagnostic test by analysing differentially expressed genes in the blood of patients diagnosed with CNP of the lower back and compared to healthy human controls. Refinement of microarray expression data was performed using correlation analysis with 3900 human 2-colour microarray experiments...
March 30, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28355887/micro-to-nanoneedles-a-trend-of-modernized-transepidermal-drug-delivery-system
#13
Pravin Shende, Mrunmayi Sardesai, R S Gaud
The transdermal route of drug delivery is convenient, pain-free and follows controlled rate release pattern. However, many therapeutically active drugs cannot cross the stratum corneum effectively. Lipophilic drugs like nifedipine cross the outer skin barrier easily and polar drugs, such as epinephrine are ineffective in showing the same effect. Due to these reasons, advancements in drug delivery have taken place to deliver a wide range of drugs, especially macromolecules through the transdermal route and directly into systemic circulation bypassing hepatic metabolism and GIT degradation...
March 30, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/28355616/medical-evacuations-in-the-oil-and-gas-industry-a-retrospective-review-with-implications-for-future-evacuation-and-preventative-strategies%C3%A2
#14
Sharyn Toner, Derkje H Andrée Wiltens, Johannes Berg, Hector Williams, Susan Klein, Simon Marshall, Neil Nerwich, Ryan Copeland
BACKGROUND: Businesses increasingly conduct operations in remote areas where medical evacuation [Medevac(s)] carries more risk. Royal Dutch Shell developed a remote healthcare strategy whereby enhanced remote healthcare is made available to the patient through use of telemedicine and telemetry. To evaluate that strategy, a review of Medevacs of Shell International employees [i.e. expatriate employees (EEs) and frequent business travellers (FBTs)] was undertaken. METHOD: A retrospective review of Medevac data (period 2008-12) that were similar in operational constraints and population profile was conducted...
May 1, 2017: Journal of Travel Medicine
https://www.readbyqxmd.com/read/28352118/body-composition-and-susceptibility-to-type-2-diabetes-an-evolutionary-perspective
#15
REVIEW
J C K Wells
Type 2 diabetes is rapidly increasing in prevalence worldwide, in concert with epidemics of obesity and sedentary behavior that are themselves tracking economic development. Within this broad pattern, susceptibility to diabetes varies substantially in association with ethnicity and nutritional exposures through the life-course. An evolutionary perspective may help understand why humans are so prone to this condition in modern environments, and why this risk is unequally distributed. A simple conceptual model treats diabetes risk as the function of two interacting traits, namely 'metabolic capacity' which promotes glucose homeostasis, and 'metabolic load' which challenges glucose homoeostasis...
March 29, 2017: European Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28347727/a-novel-method-for-examining-corneal-endothelial-cell-morphology-in-infants
#16
S R Rufai, N Y Tan, R Barbara, R Hartrey, J E Self
Previous studies suggest that central corneal endothelial cell density (ECD) decreases from 6,100 cells/mm(2) in neonates to 3,100 cells/mm(2) in 10-year-olds. Currently, there is very sparse data regarding ECD in young children as well as the trend in which ECD decreases during childhood. This is because young children were unable to comply with existing clinic-based specular microscopes. Hence, we developed a novel method of imaging young children intra-operatively to help establish age-specific normative data for ECD and hexagonality of cells (%HEX)...
March 24, 2017: Journal of AAPOS: the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus
https://www.readbyqxmd.com/read/28345565/upgradation-and-modernization-of-eye-banking-services-integrating-tradition-with-innovative-policies-and-current-best-practices
#17
Radhika Tandon, Archita Singh, Noopur Gupta, M Vanathi, Vivek Gupta
PURPOSE: The purpose of this study is to review the history and evolution of the National Eye Bank (NEB) and analyze the impact over the years and report the outcome of the invested resources. METHODS: Review of archival material, records, project reports, policy and procedures' manuals, and publications was done. Descriptive and analytical processing of data obtained was undertaken. Parameters evaluated included total collection, transplantation, utilization rates of donor cornea, changing trends over time in terms of numbers and duration of recipients waiting, impactful research translated into changes in standard operating protocols, new facilities, and subsequent effects on numbers or quality assurance measures and overview of major achievements...
February 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/28343208/legal-features-of-the-drug-advertising
#18
Vitalii M Pashkov, Andrii A Olefir, Oleksiy Y Bytyak
INTRODUCTION: In the article discribed current trends of advertising in the pharmaceutical market and foreign experience of legal regulation of these relations. As for the advertising of medicines identified it's symptoms, types, basic rules and prohibitions. Modern pharmaceutical companies can not successfully carry out economic activities without advertising. Besides we can mention some fundamental changes in society (information overload, universal access to internet, social media, freedom of movement of goods, labor and finance), also self-medication becomes more popular...
2017: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/28342340/cellulose-decomposition-and-larval-biomass-production-from-the-co-digestion-of-dairy-manure-and-chicken-manure-by-mini-livestock-hermetia-illucens-l
#19
Kashif Ur Rehman, Minmin Cai, Xiaopeng Xiao, Longyu Zheng, Hui Wang, Abdul Aziz Soomro, Yusha Zhou, Wu Li, Ziniu Yu, Jibin Zhang
World trends toward the modern dairies intensification on large production units cause massive animal manure production and accumulation. Improper handling of manure produced by industrial farm operation greatly deteriorates the major environmental media including air, water and soil. The black soldier fly utilizes organic waste and converts it into larvae biomass to be used as livestock feed and into residues to be used as bio-fertilizer. However, due to the high ratio of cellulose, hemicellulose and lignin in dairy manure, this conversion is difficult...
March 22, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28335373/dietary-patterns-and-insomnia-symptoms-in-chinese-adults-the-china-kadoorie-biobank
#20
Canqing Yu, Zumin Shi, Jun Lv, Yu Guo, Zheng Bian, Huaidong Du, Yiping Chen, Ran Tao, Ying Huang, Junshi Chen, Zhengming Chen, Liming Li
Limited attention has been paid to the effect of dietary patterns on sleep problems. In the present study, we analyzed the cross-sectional data of 481,242 adults aged 30-79 years from the China Kadoorie Biobank. A laptop-based questionnaire was administered to collect information on food intakes and insomnia symptoms. Logistic regression was used to estimate the odds ratios of each insomnia symptom according to quartiles of each dietary pattern, with adjustment for potential confounders. Two major dietary patterns were derived by factor analysis...
March 4, 2017: Nutrients
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