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https://www.readbyqxmd.com/read/29780075/prognostic-utility-of-indoxyl-sulfate-for-patients-with-acute-coronary-syndrome
#1
Ippei Watanabe, Junko Tatebe, Takahiro Fujii, Ryota Noike, Daiga Saito, Hideki Koike, Takayuki Yabe, Ryo Okubo, Rine Nakanishi, Hideo Amano, Mikihito Toda, Takanori Ikeda, Toshisuke Morita
AIM: We investigated whether indoxyl sulfate (IS), a protein-bound uremic toxin, predicts prognosis after acute coronary syndrome (ACS). METHODS: Serum IS level was determined prospectively in 98 patients who underwent successful primary percutaneous coronary intervention for ACS. Patients on hemodialysis were excluded. The endpoint of this study was six-month composite events including death, nonfatal myocardial infarction, heart failure requiring hospitalization, and adverse bleeding events...
May 19, 2018: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/29761721/association-between-serum-s100a1-level-and-global-registry-of-acute-coronary-events-score-in-patients-with-non-st-segment-elevation-acute-coronary-syndrome
#2
Yuanmin Li, Chenjun Han, Peng Zhang, Wangfu Zang, Rong Guo
Objective Acute coronary syndrome (ACS) is associated with several clinical syndromes, one of which is acute non-ST-segment ACS (NSTE-ACS). S100A1 is a calcium-dependent regulator of heart contraction and relaxation. We investigated the association between the serum S100A1 level and the Global Registry of Acute Coronary Events (GRACE) risk score in patients with NSTE-ACS and the potential of using the serum S100A1 level to predict the 30-day prognosis of NSTE-ACS. Methods The clinical characteristics of 162 patients with NSTE-ACS were analyzed to determine the GRACE score...
January 1, 2018: Journal of International Medical Research
https://www.readbyqxmd.com/read/29760219/detectable-high-sensitivity-cardiac-troponin-within-the-population-reference-interval-conveys-high-5-year-cardiovascular-risk-an-observational-study
#3
Martin P Than, Sally J Aldous, Richard W Troughton, Christopher J Pemberton, A Mark Richards, Christopher M A Frampton, Christopher M Florkowski, Peter M George, Samantha Bailey, Joanna M Young, Louise Cullen, Jaimi H Greenslade, William A Parsonage, Brendan M Everett, W Frank Peacock, Allan S Jaffe, John W Pickering
BACKGROUND: Increased cardiac troponin I or T detected by high-sensitivity assays (hs-cTnI or hs-cTnT) confers an increased risk of adverse prognosis. We determined whether patients presenting with putatively normal, detectable cTn concentrations [> limit of detection and < upper reference limit (URL)] have increased risk of major adverse cardiovascular events (MACE) or all-cause mortality. METHODS: A prospective 5-year follow-up of patients recruited in the emergency department with possible acute coronary syndrome (ACS) and cTn concentrations measured with hs-cTnI (Abbott) and hs-cTnT (Roche) assays...
May 14, 2018: Clinical Chemistry
https://www.readbyqxmd.com/read/29754668/resource-utilization-and-outcome-among-patients-with-selective-versus-nonselective-troponin-testing
#4
Alex R Campbell, Alexander J Rodriguez, David M Larson, Craig E Strauss, Ross F Garberich, Matthew F Partridge, Timothy D Henry, Scott W Sharkey
OBJECTIVE: In patients with suspected acute coronary syndrome (ACS), troponin testing is effective for diagnosis and prognosis. Troponin testing has now expanded to include patients without suspected ACS. This nonselective troponin testing has unknown consequences for resource utilization and outcome. Therefore, we examined selective versus nonselective troponin testing with respect to patient characteristics, resource utilization, and outcome. METHODS: This retrospective 1-year study included all patients with troponin testing at a U...
May 2018: American Heart Journal
https://www.readbyqxmd.com/read/29747915/prognostic-and-practical-validation-of-current-definitions-of-myocardial-infarction-associated-with-percutaneous-coronary-intervention
#5
Pierluigi Tricoci, L Kristin Newby, Robert M Clare, Sergio Leonardi, C Michael Gibson, Robert P Giugliano, Paul W Armstrong, Frans Van de Werf, Gilles Montalescot, David J Moliterno, Claes Held, Philip E Aylward, Lars Wallentin, Robert A Harrington, Eugene Braunwald, Kenneth W Mahaffey, Harvey D White
OBJECTIVES: In 13,038 patients with non-ST-segment elevation acute coronary syndrome undergoing index percutaneous coronary intervention (PCI) in the EARLY ACS (Early Glycoprotein IIb/IIIa Inhibition in Non-ST-Segment Elevation Acute Coronary Syndrome) and TRACER (Thrombin Receptor Antagonist for Clinical Event Reduction in Acute Coronary Syndrome) trials, the relationship between PCI-related myocardial infarction (MI) and 1-year mortality was assessed. BACKGROUND: The definition of PCI-related MI is controversial...
May 14, 2018: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/29747324/-prognostic-value-of-myeloperoxidase-concentration-in-patients-with-acute-coronary-syndrome
#6
S C Liu, T C Yi, H Y Weng, L Zhang, Y X Li, Momin Mohetaboer, Y Zhang, J Jiang, J P Li, Y Huo
Objective: To evaluate the difference of plasma myeloperoxidase (MPO) level in different types of acute coronary syndrome (ACS) patients, and the value of baseline MPO level in predicting short-term and long-term outcomes in patients with ACS. Methods: The study cohort was derived from "the 12th Five-Year" National Science and Technology Support Program Project "Study on Comprehensive Intervention and Prognosis of Acute Coronary Syndrome" . We enrolled all hospitalized ACS patients who were enrolled in "the 12th Five-Year" cohort from January 1, 2011 to December 31, 2013...
April 24, 2018: Zhonghua Xin Xue Guan Bing za Zhi
https://www.readbyqxmd.com/read/29743902/early-and-long-term-outcomes-of-complete-revascularization-with-percutaneous-coronary-intervention-in-patients-with-multivessel-coronary-artery-disease-presenting-with-non-st-segment-elevation-acute-coronary-syndromes
#7
Michał Hawranek, Piotr Desperak, Paweł Gąsior, Aneta Desperak, Andrzej Lekston, Mariusz Gąsior
Introduction: The clinical significance of complete revascularization with percutaneous coronary intervention (CR-PCI) in patients with non-ST-segment acute coronary syndrome (NSTE-ACS) remains uncertain. Aim: To evaluate the impact of CR-PCI during index hospitalization on short and long-term incidence of death and composite endpoint among patients with multivessel coronary artery disease (CAD) presenting with NSTE-ACS. Material and methods: We analyzed consecutive data of 1,592 patients with multivessel CAD from 2006 to 2014...
2018: Postępy W Kardiologii Interwencyjnej, Advances in Interventional Cardiology
https://www.readbyqxmd.com/read/29716535/predictive-value-of-neutrophil-to-lymphocyte-ratio-in-patients-with-acute-st-segment-elevation-myocardial-infarction-after-percutaneous-coronary-intervention-a-meta-analysis
#8
Sai Zhang, Jun Diao, Chunmei Qi, Jingjing Jin, Li Li, Xingjuan Gao, Lei Gong, Weiheng Wu
BACKGROUND: The neutrophil to lymphocyte ratio (NLR) is an indicator of systemic inflammation and a prognostic marker in patients with acute coronary syndrome (ACS). This study aims to investigate the value of NLR to predict the in-hospital and long-term prognosis in patients with ST segment elevation myocardial infarction (STEMI) after percutaneous coronary intervention (PCI) by meta-analysis. METHOD: The studies related to the prognosis of NLR and STEMI patients published in the Pubmed, Embase, and Ovid databases before June 2017 were retrieved...
May 2, 2018: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/29715175/prognostic-implications-of-detectable-cardiac-troponin-i-below-the-99th-percentile-in-patients-admitted-to-an-emergency-department-without-acute-coronary-syndrome
#9
Alfredo Bardají, Gil Bonet, Anna Carrasquer, Maribel González-Del Hoyo, Fernando Domínguez, Rafael Sánchez, Carme Boqué, Germán Cediel
BACKGROUND: Detectable troponin below the 99th percentile may reflect an underlying cardiac abnormality which might entail prognostic consequences. This study aimed to investigate the prognosis of patients admitted to an emergency department (ED) with detectable troponin below the 99th percentile reference limit who did not present with an acute coronary syndrome (ACS). METHODS: We analysed the clinical data of all consecutive patients admitted to the ED during the years 2012 and 2013 in whom cardiac troponin was requested by the attending clinician (cTnI Ultra Siemens, Advia Centaur)...
May 1, 2018: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/29708956/optimal-management-of-cancer-patients-with-acute-coronary-syndrome
#10
Waldemar Banasiak, Robert Zymliński, Anetta Undas
Cancer at various stages and therapy is observed in about 15% of patients with acute coronary syndrome (ACS). Current guidelines for invasive and conservative treatment of ACS cannot be applied to all patients with cancer. The choice of antiplatelet and anticoagulant drugs should be individualized with clopidogrel as a key P2Y12 inhibitor in this population. Major challenges of therapy in patients with ACS and cancer include limitations for the use of the recommended antithrombotic therapy (particularly in case of cancer-related thrombocytopenia or when anticoagulation is needed due to concomitant atrial fibrillation or venous thromboembolism), the management of bleeding complications, eligibility criteria for cancer surgery, and reinitiation of chemotherapy or radiotherapy after ACS...
April 30, 2018: Polish Archives of Internal Medicine
https://www.readbyqxmd.com/read/29685010/expressions-and-clinical-significance-of-factors-related-to-acute-coronary-syndrome
#11
H Sun, J Zhang, Y Zheng, S Shang
Acute coronary syndrome (ACS) is the acute stage of coronary artery disease, which remains a major cause of mortality and morbidity. It is essential to explore the role of matrix metalloproteinase -2 (MMP-2) and interleukin (IL)-18 and their association with disease in patients with severe ACS. Circulating MMP-2 and IL-18 levels were measured using enzyme linked immunosorbent assay (ELISA) in 94 subjects with acute coronary syndrome (ACS, n=38), stable angina pectoris (SAP, n=27) and healthy individuals (control group, n=29)...
March 2018: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/29662508/obstructive-sleep-apnea-is-associated-with-severity-and-long-term-prognosis-of-acute-coronary-syndrome
#12
Shuo Jia, Yu-Jie Zhou, Yi Yu, Si-Jing Wu, Yan Sun, Zhi-Jian Wang, Xiao-Li Liu, Bright Eric King, Ying-Xin Zhao, Dong-Mei Shi, Yu-Yang Liu, Zhi-Ming Zhou
Background: Obstructive sleep apnea (OSA) is a common disease in patients with acute coronary syndrome (ACS) and associated with an increased risk of fatal and nonfatal cardiovascular events. However, most patients in previous study were treated with bare metal stents and the sample sizes were relatively low. The goal of this study was to evaluate the influence of OSA on the severity and prognosis of patients admitted for ACS. Methods: In this prospective cohort study, we enrolled patients with ACS who were hospitalized for coronary angiogram/percutaneous coronary intervention and undergone polysomnography...
February 2018: Journal of Geriatric Cardiology: JGC
https://www.readbyqxmd.com/read/29624523/optimizing-a-positive-psychology-intervention-to-promote-health-behaviors-following-an-acute-coronary-syndrome-the-positive-emotions-after-acute-coronary-events-iii-peace-iii-randomized-factorial-trial
#13
Christopher M Celano, Ariana M Albanese, Rachel A Millstein, Carol A Mastromauro, Wei-Jean Chung, Kirsti A Campbell, Sean R Legler, Elyse R Park, Brian C Healy, Linda M Collins, James L Januzzi, Jeff C Huffman
OBJECTIVE: Despite the clear benefits of physical activity and related behaviors on prognosis, most patients suffering an acute coronary syndrome (ACS) remain nonadherent to these behaviors. Deficits in positive psychological constructs (e.g., optimism) are linked to reduced participation in health behaviors, supporting the potential utility of a positive psychology (PP)-based intervention in post-ACS patients. Accordingly, we aimed to identify optimal components of a PP-based intervention to promote post-ACS physical activity...
April 5, 2018: Psychosomatic Medicine
https://www.readbyqxmd.com/read/29622507/serum-neutrophil-gelatinase-associated-lipocalin-ngal-concentration-is-independently-associated-with-mortality-in-patients-with-acute-coronary-syndrome
#14
Ståle H Nymo, Marianne Hartford, Thor Ueland, Arne Yndestad, Erik Lorentzen, Katarina Truvé, Thomas Karlsson, Annica Ravn-Fischer, Pål Aukrust, Kenneth Caidahl
BACKGROUND: Circulating neutrophil gelatinase-associated lipocalin (NGAL) concentration increases in cardiovascular disease, but the long-term prognostic value of NGAL concentration has not been evaluated in acute coronary syndrome (ACS). We examined the association between NGAL concentration and prognosis in patients with ACS after non-ST-elevation myocardial infarction (NSTEMI) or STEMI. METHODS AND RESULTS: NGAL concentration was measured in blood from 1121 consecutive ACS patients (30% women, mean age 65 years) on the first morning after admission...
March 8, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29622456/%C3%AE-blocker-treatment-and-prognosis-in-acute-coronary-syndrome-associated-with-cocaine-consumption-the-ruti-cocaine-study
#15
Germán Cediel, Xavier Carrillo, Cosme García-García, Ferran Rueda, Teresa Oliveras, Carlos Labata, Jordi Serra, Marc Ferrer, Oriol de Diego, Antoni Bayés-Genís
BACKGROUND: The use of β-blocker therapy in the setting of acute coronary syndrome (ACS) associated with cocaine consumption (ACS-ACC) is discouraged due to the risk of coronary vasoconstriction. We examined the prognostic value of β-blocker therapy in a contemporary ACS cohort. METHODS AND RESULTS: Prospective, single-center study conducted between January 2001 and December 2014 that examined cocaine use among young (≤50-year-old) consecutive patients admitted with an ACS...
June 1, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29619130/copeptin-as-a-prognostic-marker-in-acute-chest-pain-and-suspected-acute-coronary-syndrome
#16
Beata Morawiec, Damian Kawecki, Brygida Przywara-Chowaniec, Mariusz Opara, Piotr Muzyk, Lam Ho, Lui Chun Tat, Artur Gabrysiak, Olivier Muller, Ewa Nowalany-Kozielska
Background: In patients admitted with chest pain and suspected acute coronary syndrome (ACS), it is crucial to early identify those who are at higher risk of adverse events. The study aim was to assess the predictive value of copeptin in patients admitted to the emergency department with chest pain and nonconclusive ECG. Methods: Consecutive patients suspected for an ACS were enrolled prospectively. Copeptin and high-sensitive troponin T (hs-TnT) were measured at admission...
2018: Disease Markers
https://www.readbyqxmd.com/read/29606324/comparison-of-outcomes-and-intervention-among-patients-with-non-st-segment-elevation-acute-myocardial-infarction-of-those-with-a-left-circumflex-versus-those-with-a-non-left-circumflex-related-coronary-artery-from-the-elisa-3-trial
#17
Erik A Badings, Renicus S Hermanides, Salem H K The, Jan-Henk E Dambrink, Saman Rasoul, Jan Van Wijngaarden, Esther Van 't Riet, Evelien Kolkman, Wouter S Remkes, Geert Tjeerdsma, Marloes L J Van Der Wielen, Dirk J A Lok, Harry Suryapranata, Arnoud W J Van 't Hof
Previous studies found that patients with an acute coronary syndrome (ACS) due to occlusion of the left circumflex (LC) coronary artery often present without ST-elevation, leading to a delay in diagnosis and revascularization, a larger infarct size, and a worse prognosis. In this subgroup analysis of the ELISA-3 study (early or late intervention in high-risk non-ST-segment elevation acute coronary syndromes [NSTE-ACS]) incidence, characteristics and prognosis of LC-related NSTE-ACS was investigated, and the outcome of early versus late invasive strategy was compared...
May 15, 2018: American Journal of Cardiology
https://www.readbyqxmd.com/read/29601955/the-prognostic-value-of-cha-2-ds-2-vasc-and-grace-risk-scores-in-acs-patients
#18
George Trantalis, Konstantina Aggeli, Konstantinos Toutouzas, Andreas Synetos, George Latsios, Maria Drakopoulou, Vasiliki Penesopoulou, Chrysoula Patsa, Dimitrios Tousoulis
Cardiovascular diseases are the first cause of death in western societies. Therapeutic interventions in the individual patient should be guided by the so-called ischemic risk of this patient. PURPOSE: The aim of the study was to study the ischemic prognostic scores GRACE and CHA2 DS2 -VASc, in patients underwent angioplasty to highlight which best predicts better the ischemic risk. RESULTS: 667 patients participated in the study with an average age of 61 ± 11 years and were followed-up for 2 years...
March 27, 2018: Hellenic Journal of Cardiology: HJC, Hellēnikē Kardiologikē Epitheōrēsē
https://www.readbyqxmd.com/read/29574074/prevalence-management-and-outcomes-of-familial-hypercholesterolemia-in-patients-with-acute-coronary-syndromes-in-the-arabian-gulf
#19
Khalid Al-Rasadi, Ibrahim Al-Zakwani, Alawi A Alsheikh-Ali, Wael Almahmeed, Wafa Rashed, Mustafa Ridha, Raul D Santos, Mohammad Zubaid
BACKGROUND: Information on the epidemiology of familial hypercholesterolemia (FH) in the Arabian Gulf region, which has an elevated rate of consanguinity and type II diabetes, is scarce. OBJECTIVES: To assess the prevalence of FH, its management, and impact on atherosclerotic cardiovascular disease (ASCVD) outcomes in a multicenter cohort of Arabian Gulf patients with acute coronary syndrome (ACS). METHODS: Patients (N = 3224) hospitalized with ACS were studied...
February 14, 2018: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/29558752/lateral-medullary-infarction-with-or-without-extra-lateral-medullary-lesions-what-is-the-difference
#20
Hyun Goo Kang, Bum Joon Kim, Sang Hun Lee, Dong-Wha Kang, Sun U Kwon, Jong S Kim
BACKGROUND: Lateral medullary infarction (LMI) is not an uncommon disease. Although lesions are usually restricted to the lateral medullary area, some patients have additional infarcts in other parts of the brain. The clinical features and prognosis of isolated LMI (pure LMI, LMIpr) have been investigated. However, it remains unclear whether clinical characteristics, prognosis and factors associated with prognosis differ between patients with LMIpr and those with additional lesions (LMI plus, LMIpl)...
2018: Cerebrovascular Diseases
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