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Gilles Lemesle, Guillaume Schurtz, Thibaud Meurice, Olivier Tricot, Nestor Lemaire, Sébastien Caudmont, André Philias, Régis Ketelers, Nicolas Lamblin, Christophe Bauters
BACKGROUND: Clopidogrel use as single antiplatelet therapy (SAPT) has never been evaluated in stable coronary artery disease (CAD) outpatients either as compared to placebo or aspirin. METHODS: We therefore studied 2,823 outpatients included in a prospective registry. The patients were divided into 2 groups according to their antiplatelet therapy regimen: patients treated with clopidogrel were compared with those treated with aspirin alone. RESULTS: The mean time since CAD diagnosis was 7...
2016: Cardiology
Ernesto Bonilla
Worldwide, children can be found who reported that they have memories of a previous life. More than 2,500 cases have been studied and their specifications have been published and preserved in the archives of the Division of Perceptual Studies at the University of Virginia (United States). Many of those children come from countries where the majority of the inhabitants believe in reincarnation, but others come from countries with different cultures and religions that reject it. In many cases, the revelations of the children have been verified and have corresponded to a particular individual, already dead...
June 2015: Investigación Clínica
Edgar R Wood, Randy Bledsoe, Jing Chai, Philias Daka, Hongfeng Deng, Yun Ding, Sarah Harris-Gurley, Luz Helena Kryn, Eldridge Nartey, James Nichols, Robert T Nolte, Ninad Prabhu, Cecil Rise, Timothy Sheahan, J Brad Shotwell, Danielle Smith, Vince Tai, J David Taylor, Ginger Tomberlin, Liping Wang, Bruce Wisely, Shihyun You, Bing Xia, Hamilton Dickson
2',5'-Oligoadenylate synthetase (OAS) enzymes and RNase-L constitute a major effector arm of interferon (IFN)-mediated antiviral defense. OAS produces a unique oligonucleotide second messenger, 2',5'-oligoadenylate (2-5A), that binds and activates RNase-L. This pathway is down-regulated by virus- and host-encoded enzymes that degrade 2-5A. Phosphodiesterase 12 (PDE12) was the first cellular 2-5A- degrading enzyme to be purified and described at a molecular level. Inhibition of PDE12 may up-regulate the OAS/RNase-L pathway in response to viral infection resulting in increased resistance to a variety of viral pathogens...
August 7, 2015: Journal of Biological Chemistry
A Ichinose, T Osaki, M Souri
INTRODUCTION: Autoimmune haemophilia-like disease (or haemorrha-philia) due to anti-factor XIII (FXIII; F13 to avoid confusion with FVIII or FXII) antibodies (termed AH13) is a severe bleeding disorder. Although AH13 is thought to be rare, 'the number of its diagnosed patients' has recently increased in Japan. However, its prevalence remains unknown. AIM: To improve understanding of this disease, we examined and diagnosed 32 'new' Japanese patients with AH13. METHODS: The presence of antibodies against F13-A subunit and/or F13-B subunit was confirmed by using a dot blot test and enzyme-linked immunosorbent assays...
September 2015: Haemophilia: the Official Journal of the World Federation of Hemophilia
M Souri, T Osaki, A Ichinose
BACKGROUND: Autoimmune hemophilia-like disease (hemorrha-philia or hemorrhagic disorder) caused by anti-factor XIII antibodies (termed AH13) or 'autoimmune FXIII deficiency' is a life-threatening bleeding disorder. AH13 was thought to be rare worldwide. OBJECTIVES: Because the number of diagnosed AH13 cases has recently been increasing, at least in Japan, we conducted a nationwide survey supported by the Japanese Ministry of Health, Labor, and Welfare, and explored the pathologic mechanism(s) of AH13...
May 2015: Journal of Thrombosis and Haemostasis: JTH
Philias Daka, Aiguo Liu, Chamini Karunaratne, Erika Csatary, Cameron Williams, Hui Xiao, Jiayuh Lin, Zhenghu Xu, Richard C Page, Hong Wang
Inhibition of the signaling pathways of signal transducer and activator of transcription 3 (STAT 3) has shown to be a promising strategy to combat cancer. In this paper we report the design, synthesis and evaluation of a novel class of small molecule inhibitors, that is, XZH-5 and its analogues, as promising leads for further development of STAT3 inhibitors. Preliminary SARs was established for XZH-5 and its derivatives; and the binding modes were predicted by molecular docking. Lead compounds with IC50 as low as 6...
March 15, 2015: Bioorganic & Medicinal Chemistry
Taghogho Agarin, Ejine Okorafor, Vasanth Kailasam, Aniefiok Agarin, Willy Philias, Dianelys Garcia, Uzoma Osuchukwu, Dimy Fluyah, Chinedu Iheagwara, Dennis Donovan, Carol Roberts, Deepika Singh, Charles Nnadi, Zafar Sharif
Dropping out of scheduled care leads to medication non adherence, increased morbidity, relapse and readmission rates. As part of a performance improvement project to increase attendance rates at our outpatient clinic, psychiatric residents and Behavioral Health Technicians made reminder telephone calls under similar circumstances. We compared follow up appointment rates in the two groups. Our analysis showed that there was no significant difference in the rates of kept appointment overall between the two groups...
April 2015: Community Mental Health Journal
Nai-Gang Zheng, Sai-Jun Mo, Jin-Ping Li, Jing-Lan Wu
CD133 was recently reported to be a cancer stem cell and prognostic marker. Quercetin is considered as a potential chemopreventive agent due to its involvement in suppression of oxidative stress, proliferation and metastasis. In this study, the expression of CD133/CD44 in esophageal carcinomas and Eca109/9706 cells was explored. In immunoflurorescence the locations of CD133+ and multidrug resistance 1 (MDR 1)+ in the same E-cancer cells were coincident, mainly in cytomembranes. In esophageal squamous cell carcinomas detected by double/single immunocytochemistry, small CD133+ cells were located in the basal layer of stratified squamous epithelium, determined as CSLC (cancer stem like cells); CD44+ surrounding the cells appeared in diffuse pattern, and the larger CD44+ (hi) cells were mainly located in the prickle cell layer of the epithelium, as progenitor cells...
2014: Asian Pacific Journal of Cancer Prevention: APJCP
Akitada Ichinose
Factor XIII/13 (FXIII or F13) is a plasma protransglutaminase, which stabilizes fibrin clots, and thus plays an important role in hemostasis. Autoimmune hemo(rrha)philia due to anti-F13 autoantibodies (AH13) has been on the rise in Japan, which has become the leading superaging society in the 21st century. The mean age of Japanese AH13 cases has risen to 70.4 years. A total of 83 AH13 cases have been diagnosed in the world as of July 2014. To raise the awareness of AH13, the author and members of the Japanese Collaborative Research Group first proposed "Criterion and Algorithm of Laboratory Tests for anti F13" in February 2012...
September 2014: Seminars in Thrombosis and Hemostasis
Xianghua Wang, Shuli Dong, Zhili Yao, Lei Feng, Philias Daka, Hong Wang, Zhenghu Xu
A novel tandem metal relay catalytic system was developed by combining gold-catalyzed cycloisomerization with an early transition-metal-catalyzed inverse-electron-demand hetero-Diels-Alder (IED-HDA) reaction. Various biologically important spiroaminals and spiroketals were obtained with very high efficiency under mild conditions.
January 3, 2014: Organic Letters
Philia Gau, Jason Poon, Carmen Ufret-Vincenty, Corey D Snelson, Sharona E Gordon, David W Raible, Ajay Dhaka
The ability to detect hot temperatures is critical to maintaining body temperature and avoiding injury in diverse animals from insects to mammals. Zebrafish embryos, when given a choice, actively avoid hot temperatures and display an increase in locomotion similar to that seen when they are exposed to noxious compounds such as mustard oil. Phylogenetic analysis suggests that the single zebrafish ortholog of TRPV1/2 may have arisen from an evolutionary precursor of the mammalian TRPV1 and TRPV2. As opposed to TRPV2, mammalian TRPV1 is essential for environmentally relevant heat sensation...
March 20, 2013: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
Philias Daka, Zhenghu Xu, Alexandru Alexa, Hong Wang
A novel class of primary amine-metal Lewis acid bifunctional catalysts based on a bidentate ligand was developed. These catalysts were highly efficient in catalyzing the direct asymmetric aldol reactions of ketones offering excellent stereoselectivity. The aldol reactions required a low catalyst loading (2.5 mol%), and were water compatible.
January 7, 2011: Chemical Communications: Chem Comm
D Lossignol
This paper presents the medical practice according to the occidental philosophy (Platon, Spinoza, Kant). Relationships with the concept of "love" (eros, philia, agape) will be described, and the concept of dignity and autonomy as well. The reflection will focus on the end of life aspects. Although medicine cannot avoid morality, ethic, and deontology, it is also part of philosophy and must warrant the respect of human dignity, especially when a physician helps a patient to die.
January 2010: Revue Médicale de Bruxelles
Zhenghu Xu, Philias Daka, Hong Wang
The first example of metal Lewis acid-primary amine bifunctional cooperative catalyst derived from primary amino acids was developed, and it was found to catalyze aldol reactions of cyclic ketones highly efficiently with very good to excellent stereoselectivities.
November 28, 2009: Chemical Communications: Chem Comm
Christine Savoye, Octave Equine, Olivier Tricot, Olivier Nugue, Benoit Segrestin, Karine Sautière, Mariam Elkohen, Eduard Matei Pretorian, Kouroch Taghipour, André Philias, Valérie Aumégeat, Eric Decoulx, Pierre V Ennezat, Christophe Bauters et al.
Left ventricular (LV) remodeling after acute myocardial infarction (AMI) has been well described in previous studies. However, there is a paucity of data on the incidence of and risk factors for LV remodeling in modern clinical practice that incorporates widespread use of acute reperfusion strategies and almost systematic use of "antiremodeling" medications, such as angiotensin-converting enzyme inhibitors and beta blockers. We enrolled 266 patients with anterior wall Q-wave AMI who had >or=3 segments of the infarct zone that were akinetic on echocardiography before discharge...
November 1, 2006: American Journal of Cardiology
Bernard E Rollin
Moral psychology is often ignored in ethical theory, making applied ethics difficult to achieve in practice. This is particularly true in the new field of animal ethics. One key feature of moral psychology is recognition of the moral primacy of those with whom we enjoy relationships of love and friendship--philia in Aristotle's term. Although a radically new ethic for animal treatment is emerging in society, its full expression is severely limited by our exploitative uses of animals. At this historical moment, only the animals with whom we enjoy philia--companion animals--can be treated with unrestricted moral concern...
April 2005: Ethical Theory and Moral Practice: An International Forum
Joyce Davidson, Mick Smith
In modern society natural objects like spiders or snakes have a primary role as the loci of specific phobias. Drawing on interviews with members of the UK National Phobics Society (NPS) and associated service providers, this paper explores the implications of the increasingly significant role played by new media, particularly Virtual Reality technologies, in the treatment of these 'bio-phobias'. While advanced technological approaches provide new possibilities for individual sufferers to experiment with and control their phobic responses they also exemplify certain aspects of those specifically modern social relations that are the media within which bio-phobic behaviours develop...
September 2003: Sociology of Health & Illness
Erwin W Gelfand, Zhi-Hua Cui, Katsuyuki Takeda, Arihiko Kanehiro, Anthony Joetham
BACKGROUND: Antihistamines have been evaluated for usefulness in the treatment of asthma for more than 50 years. Interest was limited until the introduction of newer compounds that were free of much of the dose-limiting sedation associated with the earlier drugs. OBJECTIVE: In a murine model of allergen-induced airway inflammation and hyperresponsiveness, the efficacy of an H1 receptor antagonist to prevent allergic inflammation and altered airway function was evaluated...
July 2002: Journal of Allergy and Clinical Immunology
I Stevenson
Several disorders or abnormalities observed in medicine and psychology are not explicable (or not fully explicable) by genetics and environmental influences, either alone or together. These include phobias and philias observed in early infancy, unusual play in childhood, homosexuality, gender identity disorder, a child's idea of having parents other than its own, differences in temperament manifested soon after birth, unusual birthmarks and their correspondence with wounds on a deceased person, unusual birth defects, and differences (physical and behavioral) between monozygotic twins...
April 2000: Medical Hypotheses
J W Shields
From 1578-1628, Fabricius and his pupils, Asellius and Harvey, sequentially laid the foundations for the modern sciences of comparative anatomy, lymphology and circulation, as well as a state of lympho-philia or "-mania" which persists to the present time. Lymphomania persists because there remains a fundamental controversy and ignorance about the precise functions of lymph, lymphatics, lymph glands, lymphocytes, and the bursa of Fabricius. In 1778, William Hewson deduced that lymph effluent from lymph glands contains globular particles essential to normal body growth and tissue repair...
March 1994: Lymphology
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