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Christos S Karapetis, Lisa Guccione, Martin Hn Tattersall, Helen Gooden, Claire M Vajdic, Sylvie Lambert, Monica Robotin, Linda Mileshkin, Penelope Schofield
INTRODUCTION: Despite being the 6(th) cause of cancer death in Australia, cancer of unknown primary (CUP) site remains poorly understood. AIMS: To describe practices relating to the diagnosis, investigation, classification, communication and management of CUP amongst medical oncologists. METHODS: We invited all members of the Medical Oncology Group of Australia to participate in a national, anonymous online survey about CUP. The survey collected data regarding diagnosis acceptance, diagnostic tests, treatment protocols and communication practices around the diagnosis of CUP...
January 19, 2017: Internal Medicine Journal
Trent M Guess, Swithin Razu
The menisci of the knee reduce tibiofemoral contact pressures and aid in knee lubrication and nourishment. Meniscal injury occurs in half of knees sustaining anterior cruciate ligament injury and the vast majority of tears in the medial meniscus transpire in the posterior horn region. In this study, computational multibody models of the knee were derived from medical images and passive leg motion for two female subjects. The models were validated against experimental measures available in the literature and then used to evaluate medial meniscus contact force and internal hoop tension...
January 11, 2017: Medical Engineering & Physics
Ming-Xiong Huang, Bill Anderson, Charles W Huang, Gerd J Kunde, Erika C Vreeland, Jeffrey W Huang, Andrei N Matlashov, Todor Karaulanov, Christopher P Nettles, Andrew Gomez, Kayla Minser, Caroline Weldon, Giulio Paciotti, Michael Harsh, Roland R Lee, Edward R Flynn
Superparamagnetic relaxometry (SPMR) is a highly sensitive technique for the in vivo detection of tumor cells and may improve early stage detection of cancers. SPMR employs superparamagnetic iron oxide nanoparticles (SPION). After a brief magnetizing pulse is used to align the SPION, SPMR measures the time decay of SPION using super-conducting quantum interference device (SQUID) sensors. Substantial research has been carried out in developing the SQUID hardware and in improving the properties of the SPION. However, little research has been done in the pre-processing of sensor signals and post-processing source modeling in SPMR...
February 7, 2017: Physics in Medicine and Biology
Ahmet Erdemir, Trent M Guess, Jason P Halloran, Luca Modenese, Jeffrey A Reinbolt, Darryl G Thelen, Brian R Umberger, Ahmet Erdemir, Trent M Guess, Jason P Halloran, Luca Modenese, Jeffrey A Reinbolt, Darryl G Thelen, Brian R Umberger, Brian R Umberger, Ahmet Erdemir, Darryl G Thelen, Trent M Guess, Jeffrey A Reinbolt, Luca Modenese, Jason P Halloran
OBJECTIVE: The overall goal of this paper is to demonstrate that dissemination of models and analyses for assessing the reproducibility of simulation results can be incorporated in the scientific review process in biomechanics. METHODS: As part of a special issue on model sharing and reproducibility in the IEEE Transactions on Biomedical Engineering, two manuscripts on computational biomechanics were submitted: Rajagopal et al., IEEE Trans. Biomed. Eng., 2016 and Schmitz and Piovesan, IEEE Trans...
October 2016: IEEE Transactions on Bio-medical Engineering
Alexander Kautzky, Pia Baldinger-Melich, Georg S Kranz, Thomas Vanicek, Daniel Souery, Stuart Montgomery, Julien Mendlewicz, Joseph Zohar, Alessandro Serretti, Rupert Lanzenberger, Siegfried Kasper
OBJECTIVE: Despite a broad arsenal of antidepressants, about a third of patients suffering from major depressive disorder (MDD) do not respond sufficiently to adequate treatment. Using the data pool of the Group for the Study of Resistant Depression and machine learning, we intended to draw new insights featuring 48 clinical, sociodemographic, and psychosocial predictors for treatment outcome. METHOD: Patients were enrolled starting from January 2000 and diagnosed according to DSM-IV...
January 3, 2017: Journal of Clinical Psychiatry
Kohei Yatabe, Kenji Ishikawa, Yasuhiro Oikawa
This paper presents a non-iterative phase retrieval method from randomly phase-shifted fringe images. By combining the hyperaccurate least squares ellipse fitting method with the subspace method (usually called the principal component analysis), a fast and accurate phase retrieval algorithm is realized. The proposed method is simple, flexible, and accurate. It can be easily coded without iteration, initial guess, or tuning parameter. Its flexibility comes from the fact that totally random phase-shifting steps and any number of fringe images greater than two are acceptable without any specific treatment...
January 1, 2017: Journal of the Optical Society of America. A, Optics, Image Science, and Vision
Peter Hegarty
Drawing together social psychologists' concerns with equality and cognitive psychologists' concerns with scientific inference, 6 studies (N = 841) showed how implicit category norms make the generation and test of hypothesis about race highly asymmetric. Having shown that Whiteness is the default race of celebrity actors (Study 1), Study 2 used a variant of Wason's (1960) rule discovery task to demonstrate greater difficulty in discovering rules that require specifying that race is shared by White celebrity actors than by Black celebrity actors...
January 2017: Journal of Experimental Psychology. General
S Lim, K Kainz, X Li
PURPOSE: An objective of retreatment planning is to minimize dose to previously irradiated tissues. Conventional retreatment planning is based largely on best-guess superposition of the previous treatment's isodose lines. In this study, we report a rigorous, automated retreatment planning process to minimize dose to previously irradiated organs at risk (OAR). METHODS: Data for representative patients previously treated using helical tomotherapy and later retreated in the vicinity of the original disease site were retrospectively analyzed in an automated fashion using a prototype treatment planning system equipped with a retreatment planning module (Accuray, Inc...
June 2016: Medical Physics
A Derksen, L Koenig, H Meine, S Heldmann
PURPOSE: To improve results of deformable image registration (DIR) in adaptive radiotherapy for large bladder deformations in CT/CBCT pelvis imaging. METHODS: A variational multi-modal DIR algorithm is incorporated in a joint iterative scheme, alternating between segmentation based bladder matching and registration. Using an initial DIR to propagate the bladder contour to the CBCT, in a segmentation step the contour is improved by discrete image gradient sampling along all surface normals and adapting the delineation to match the location of each maximum (with a search range of +-5/2mm at the superior/inferior bladder side and step size of 0...
June 2016: Medical Physics
Jaewook Jung, Dongwoo Kang, Donghoon Lee, Dongho Won
Nowadays, many hospitals and medical institutes employ an authentication protocol within electronic patient records (EPR) services in order to provide protected electronic transactions in e-medicine systems. In order to establish efficient and robust health care services, numerous studies have been carried out on authentication protocols. Recently, Li et al. proposed a user authenticated key agreement scheme according to EPR information systems, arguing that their scheme is able to resist various types of attacks and preserve diverse security properties...
2017: PloS One
Samuel G Armato, Karen Drukker, Feng Li, Lubomir Hadjiiski, Georgia D Tourassi, Roger M Engelmann, Maryellen L Giger, George Redmond, Keyvan Farahani, Justin S Kirby, Laurence P Clarke
The purpose of this work is to describe the LUNGx Challenge for the computerized classification of lung nodules on diagnostic computed tomography (CT) scans as benign or malignant and report the performance of participants' computerized methods along with that of six radiologists who participated in an observer study performing the same Challenge task on the same dataset. The Challenge provided sets of calibration and testing scans, established a performance assessment process, and created an infrastructure for case dissemination and result submission...
October 2016: Journal of Medical Imaging
A Adrienne Walker, George Engelhard, Mari-Wells Hedgpeth, Kenneth D Royal
Person fit statistics provide equivocal interpretations regarding aberrant responses. This study uses person response functions (PRF) to supplement the interpretation of person fit statistics. Sixty-three multiple-choice items were administered to a sample of persons (N=31) who used guessing strategies to answer them. After answering each item, participants indicated which guessing strategy they used. The data were analyzed with a Rasch (1960) model, where the item calibrations were anchored to values obtained when the items were appropriately administered...
2016: Journal of Applied Measurement
Michael S Pratte, Young Eun Park, Rosanne L Rademaker, Frank Tong
If we view a visual scene that contains many objects, then momentarily close our eyes, some details persist while others seem to fade. Discrete models of visual working memory (VWM) assume that only a few items can be actively maintained in memory, beyond which pure guessing will emerge. Alternatively, continuous resource models assume that all items in a visual scene can be stored with some precision. Distinguishing between these competing models is challenging, however, as resource models that allow for stochastically variable precision (across items and trials) can produce error distributions that resemble random guessing behavior...
January 2017: Journal of Experimental Psychology. Human Perception and Performance
Robyn S Weisman, Ralf E Gebhard
No abstract text is available yet for this article.
January 2017: Regional Anesthesia and Pain Medicine
Slavica Dimitrieva, Ralph Schlapbach, Hubert Rehrauer
BACKGROUND: Kidney renal clear cell carcinoma (KIRC) is a type of cancer that is resistant to chemotherapy and radiotherapy and has limited treatment possibilities. Large-scale molecular profiling of KIRC tumors offers a great potential to uncover the genetic and epigenetic changes underlying this disease and to improve the clinical management of KIRC patients. However, in practice the clinicians and researchers typically focus on single-platform molecular data or on a small set of genes...
December 20, 2016: Biology Direct
Emily K Farran, Lauren Atkinson, Hannah Broadbent
The aims of this study were to: provide a precise characterisation of spatial category representations in Williams syndrome (WS); to determine the nature of the mechanistic contributions from spatial language performance and non-verbal cognition to spatial category representations in WS; and to explore the stability of spatial category representations in WS using error analysis. Spatial category representation was assessed across nine spatial categories (In, On, Under, In Front, Behind, Above, Below, Left, and Right) using an odd-one-out task...
2016: Frontiers in Psychology
Julian Hering, Erik H Waller, Georg Von Freymann
Controlling the point-spread-function in three-dimensional laser lithography is crucial for fabricating structures with highest definition and resolution. In contrast to microscopy, aberrations have to be physically corrected prior to writing, to create well defined doughnut modes, bottlebeams or multi foci modes. We report on a modified Gerchberg-Saxton algorithm for spatial-light-modulator based automated aberration compensation to optimize arbitrary laser-modes in a high numerical aperture system. Using circularly polarized light for the measurement and first-guess initial conditions for amplitude and phase of the pupil function our scalar approach outperforms recent algorithms with vectorial corrections...
December 12, 2016: Optics Express
Jo Van Herwegen, Hiwet Mariam Costa, Maria Chiara Passolunghi
Previous studies in both typically and atypically developing children have shown that approximate number system (ANS) abilities predict formal mathematical knowledge later on in life. The current study investigated whether playing specially designed training games that targets the ANS system using nonsymbolic stimuli only would improve preschool children's ANS abilities. Thirty-eight preschool children were randomly allocated to either the training or control group. For 5 weeks, 20 preschoolers (9 girls) in the training group played daily games for 10 min that included guessing and comparing numerosities, whereas 18 control children (6 girls) were involved in interactive picture book reading sessions...
December 12, 2016: School Psychology Quarterly
Emma Delhaye, Christine Bastin
Aging is accompanied by a decline in associative memory that can, however, be attenuated when associations are unitized at encoding, that is, when they form an integrated entity. Unitization is thought to promote familiarity-based recognition memory, which is preserved in aging. We examined whether preexperimentally unitized associations (compound words (CWs)) do indeed reduce age differences in memory, and whether preexperimental unitization promotes familiarity. In Experiment 1, we assessed the memory of 20 young and 20 older participants for compound versus unrelated word pairs using a yes/no recognition test with Remember/Know/Guess judgments...
December 9, 2016: Neuropsychology, Development, and Cognition. Section B, Aging, Neuropsychology and Cognition
Trent M Guess, Swithin Razu, Amirhossein Jahandar, Marjorie Skubic, Zhiyu Huo
The Microsoft Kinect is becoming a widely used tool for inexpensive, portable measurement of human motion with the potential to support clinical assessments of performance and function. In this study, the relative osteokinematic Cardan joint angles of the hip and knee were calculated using the Kinect 2.0 skeletal tracker. The pelvis segments of the default skeletal model were reoriented and three-dimensional joint angles were compared to a marker-based system during a drop vertical jump and a hip abduction motion...
December 5, 2016: Journal of Applied Biomechanics
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