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https://www.readbyqxmd.com/read/29765068/linking-cervicovaginal-immune-signatures-hpv-and-microbiota-composition-in-cervical-carcinogenesis-in-non-hispanic-and-hispanic-women
#1
Paweł Łaniewski, Dominique Barnes, Alison Goulder, Haiyan Cui, Denise J Roe, Dana M Chase, Melissa M Herbst-Kralovetz
While high-risk human papillomavirus (HPV) infection is a well-established risk factor for cervical cancer, there are likely other factors within the local microenvironment that contribute to cervical carcinogenesis. Here we investigated relationships between HPV, vaginal pH, vaginal microbiota (VMB) composition, level of genital immune mediators and severity of cervical neoplasm. We enrolled women with low- and high-grade cervical dysplasia (LGD, HGD), invasive cervical carcinoma (ICC), and healthy controls...
May 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29761764/case-report-filaria-or-megasperm-a-cause-of-an-ultrasonographic-filarial-dance-sign
#2
J Brad Wiggers, Hyun-Jung Jang, Jay S Keystone
Bancroftian filariasis can cause genital abnormalities related to chronic inflammation and obstruction of the afferent lymphatic vessels, and may demonstrate a "filarial dance sign" on scrotal ultrasound with mobile echogenic particles observed. We present a patient with a positive "filarial dance sign," travel within Latin America and negative filarial serology.
May 14, 2018: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29750417/hits-clip-reveals-sex-differential-rna-binding-and-alterative-splicing-regulation-of-srm160-in-drosophila
#3
Chen Qiu, Yu Zhang, Yu-Jie Fan, Ting-Lin Pang, Yan Su, Shuai Zhan, Yong-Zhen Xu
Serine/arginine (SR)-rich proteins are critical for the regulation of alternative splicing (AS), which generates multiple mRNA isoforms from one gene and provides protein diversity for cell differentiation and tissue development. Genetic evidence suggests that Drosophila genital-specific overexpression of SR-related nuclear matrix protein of 160 kDa (SRm160), an SR protein with a PWI RNA-binding motif, causes defective development only in male flies and results in abnormal male genital structures and abnormal testis...
May 10, 2018: Journal of Molecular Cell Biology
https://www.readbyqxmd.com/read/29729217/improving-care-for-women-with-obstetric-fistula-new-who-recommendation-on-duration-of-bladder-catheterization-after-the-surgical-repair-of-a-simple-obstetric-urinary-fistula
#4
Mariana Widmer, Özge Tunçalp, Maria Regina Torloni, Olufemi T Oladapo, Maurice Bucagu, A Metin Gülmezoglu
Under the Sustainable Development Goals (SDGs) and universal health coverage, the "survive, thrive, transform" agenda moves beyond reducing mortality and focuses on the importance of maternal morbidity.(1 ) An obstetric fistula, one of the most devastating types of maternal morbidity, is usually caused by injury during childbirth from prolonged or obstructed labour. The prolonged compression of the fetal head against the pelvic bones can cause ischaemic necrosis of parts of the bladder, urethra or vagina, resulting in an abnormal opening between a woman's genital tract and her urinary tract that leads to the continuous flow of urine through the vagina...
May 5, 2018: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/29717924/prevalence-and-burden-related-to-genital-warts-in-india
#5
Uday S Khopkar, Murlidhar Rajagopalan, Anahita R Chauhan, Smita Kothari-Talwar, Puneet K Singhal, Karen Yee, Amit Kulkarni, Nuria Lara, Montserrat Roset, Anna R Giuliano, Suzanne M Garland
The prevalence of genital warts (GW) and self-reported human papillomavirus (HPV) as well as disease-related psychosocial impact among male and female patients aged 18-60 years in India were assessed. GW prevalence was estimated using a 2-week daily log of patients examined from June 7-September 22, 2011 by 200 participating physicians in 6 regions of India. Psychosocial impact was estimated using one-time, self-administered surveys, including HPV Impact Profile (HIP), Cuestionario Específico para Condiloma Acuminado ([Spanish] CECA; "Specific questionnaire for Condylomata Acuminata") and EuroQol-5 Dimension survey...
May 2, 2018: Viral Immunology
https://www.readbyqxmd.com/read/29714466/the-relation-between-isolated-micropenis-in-childhood-with-cag-and-ggn-repeat-polymorphisms-in-the-androgen-receptor-gene
#6
Esra Tuğ, Sezen Güntekin Ergün, Mehmet Ali Ergün, Fatma Nihal Dilek, Emriye Ferda Perçin
Background/aim: In micropenis cases accompanied by external genital abnormalities such as hypospadias and cryptorchidism, infertility and spermatogenic failures have been reported to correlate with androgen receptor ( AR ) gene CAG and GGN repeat polymorphisms. While there is one study on isolated micropenis and CAG repeats, no study related to GGN repeats has been reported. We investigated the relation between CAG and GGN repeats in the AR gene with development of penis length in boys with isolated micropenis...
April 30, 2018: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/29713857/case-of-successful-ivf-treatment-of-an-oligospermic-male-with-46-xx-46-xy-chimerism
#7
R J Laursen, B Alsbjerg, I Vogel, C H Gravholt, H Elbaek, D L Lildballe, P Humaidan, E M Vestergaard
INTRODUCTION: We present a case of an infertile male with 46,XX/46,XYchimerism fathering a child after ICSI procedure. METHODS: Conventional cytogenetic analysis on chromosomes, derived from lymphocytes, using standard Q-banding procedures with a 450-550-band resolution and short-tandem-repeat analysis of 14 loci. RESULTS: Analysis of 20 metaphases from lymphocytes indicated that the proband was a karyotypic mosaic with an almost equal distribution between male and female cell lines...
April 30, 2018: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/29671733/what-should-be-the-surgeon-s-role-in-defining-normal-genital-appearance
#8
Devan Stahl, Christian J Vercler
The recent rise in women seeking cosmetic surgery of their genitalia (labiaplasty) coincides with the increasing number of surgeons posting videos of these operations on social media accounts and websites. Sociocultural influences significantly contribute to our ideas of what constitutes healthy and pathologic, and surgeons have historically played a role in defining "normal" and "abnormal" anatomy. In the nineteenth century, Saartjie Baartman-a woman with a large posterior and unusually long labia minora-was used by physicians to "educate" the public about these differences...
April 1, 2018: AMA Journal of Ethics
https://www.readbyqxmd.com/read/29666339/phenotypic-characterization-of-derivative-22-syndrome-case-series-and-review
#9
Deepti Saxena, Priyanka Srivastava, Moni Tuteja, Kausik Mandal, Shubha R Phadke
Emanuel syndrome is caused due to an additional derivative chromosome 22 and is characterized by severe intellectual disability, microcephaly, failure to thrive, preauricular tags or pits, ear anomalies, cleft or high-arched palate, micrognathia, kidney abnormalities, congenital heart defects and genital abnormalities in males. In 99% of the cases, one of the parents is a carrier of balanced translocation between chromosomes 11 and 22. It occurs due to malsegregation of the gametes with 3:1 segregation. In this case series, we describe four patients with diverse manifestations of this condition...
March 2018: Journal of Genetics
https://www.readbyqxmd.com/read/29659752/performance-of-anal-cytology-compared-with-high-resolution-anoscopy-and-histology-in-women-with-lower-anogenital-tract-neoplasia
#10
Andreia Albuquerque, Michael Sheaff, Oliver Stirrup, Carmelina Cappello, Julie Bowring, Tamzin Cuming, Anke de Masi, Adam N Rosenthal, Mayura Nathan
Background: Information on the performance of anal cytology in women who are high-risk for human papillomavirus-related lesions and the factors that might influence it are largely lacking. Aims: Evaluate the performance of anal cytology in women with lower anogenital tract neoplasia. Methods: retrospective study including all new referrals of women with a previous history of anogenital neoplasia, from January 2012 to July 2017, with concomitant anal cytology and high-resolution anoscopy with or without biopsies...
April 5, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29656585/adenocarcinoma-in-situ-admixed-with-small-cell-neuroendocrine-carcinoma-of-the-cervix-a-case-report-with-cytological-features
#11
Yukimi Nishiumi, Toshiyuki Nishimura, Ippei Kashu, Takayuki Aoki, Ryoji Itoh, Koji Tsuta, Mitsuaki Ishida
Primary cervical small cell neuroendocrine carcinoma (SCNEC) is a rare and aggressive tumor. Herein, we describe the first cytological case of adenocarcinoma in situ (AIS) admixed with SCNEC. A 65-year-old postmenopausal Japanese female presented with abnormal genital bleeding. The Papanicolaou smear of the cervix demonstrated the presence of 2 distinct neoplastic components in an inflammatory background. One component consisted of aggregates of small round cells with a high nuclear/cytoplasmic ratio and round to oval nuclei with powdery chromatin, and inconspicuous nucleoli...
April 15, 2018: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/29622552/clival-malformations-in-charge-syndrome
#12
E S Mahdi, M T Whitehead
BACKGROUND AND PURPOSE: CHARGE syndrome is a multisystemic congenital disorder, most commonly including coloboma, heart malformations, choanal atresia, developmental delay, and genital and ear anomalies. The diagnostic criteria for CHARGE syndrome have been refined with time. However, limited reports describe skull base and craniocervical junction abnormalities. Recently, a coronal clival cleft has been identified in association with CHARGE syndrome. The aim of our study was to assess the prevalence of clival pathology in CHARGE syndrome...
April 5, 2018: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/29618062/45-x-46-xy-mosaicism-presenting-with-isolated-unilateral-cryptorchidism-and-a-normal-blood-karyotype
#13
Grazia Morandi, Manuela Cerbone, Elisa B Lamback, Eleni Rapti, Mehul T Dattani
Context: 45,X/46,XY mosaicism is a disorder of sex development leading to abnormal gonadal development and to unpredictable genital phenotype, growth and pubertal development. Case Description: A two year old male presented with a right impalpable testis. Blood karyotype was 46,XY. A laparoscopy performed for right orchidopexy revealed a right streak gonad with Mullerian structures, while on the left side a normal descended testis was present. The karyotype of the removed gonad was 45,X/46,XY...
March 30, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29610178/proximal-hypospadias-and-a-novel-wt1-variant-when-should-genetic-testing-be-considered
#14
Elizabeth Dabrowski, Amy E Armstrong, Elizabeth Leeth, Emilie Johnson, Earl Cheng, Yasmin Gosiengfiao, Courtney Finlayson
We present a case of an infant with proximal hypospadias, penoscrotal transposition, and bilaterally descended testes found to have a clinically significant WT1 gene alteration on a customized disorder of sex development genetic panel in which 62 genes associated with 46, XY disorders of sex development were evaluated. This diagnosis led to early screening for and diagnosis and treatment of Wilms tumor. Patients with proximal hypospadias are not routinely evaluated by genetic testing, and when initial hormonal analyses are within normal ranges for a typical male patient, the genital atypia is usually attributed to an isolated anatomic abnormality...
April 2018: Pediatrics
https://www.readbyqxmd.com/read/29607236/a-case-of-primary-uterina-lymphoma-presenting-with-bleeding-pelvic-pain-and-dysmenorrhea
#15
Lilian Yukari Miura, Miriam Anyury Daquin Maure, Monica Tessmann Zomer, Reitan Ribeiro, Teresa Cristina Santos Cavalcanti, William Kondo
Primary non-Hodgkin's lymphoma (NHL) can arise from lymphatic cells located in solid organs (extranodal) and it accounts for 25 to 35% of all NHL. Primary lymphoma on the female genital tract (PLFGT) is a rare disease, comprising 0.2 to 1.1% of all extranodal lymphomas in the female population. In this paper, the authors report an extremely rare case of a 48-year-old woman who exhibited an abnormal uterine bleeding, pelvic pain, and dysmenorrhea history. The transvaginal ultrasound showed an anteverted uterus measuring 153 cm3 in volume, with intramural leiomyomas...
2018: Case Reports in Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29582635/possible-synergistic-interactions-among-multiple-hpv-genotypes-in-women-suffering-from-genital-neoplasia
#16
Massoud Hajia, Amir Sohrabi
Objective: Persistence of HPV infection is the true cause of cervical disorders. It is reported that competition may exist among HPV genotypes for colonization. This survey was designed to establish the multiple HPV genotype status in our community and the probability of multiple HPV infections involvement. Methods: All multiple HPV infections were selected for investigation in women suffering from genital infections referred to private laboratories in Tehran, Iran. A total of 160 multi HPV positive specimens from cervical scraping were identified by the HPV genotyping methods, "INNO-LiPA and Geno Array"...
March 27, 2018: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/29564132/large-cell-neuroendocrine-carcinoma-arising-in-the-endometrium-a-case-report
#17
Jumpei Ogura, Yasushi Adachi, Koji Yasumoto, Akiharu Okamura, Hirofumi Nonogaki, Kazuyo Kakui, Koji Yamanoi, Koh Suginami, Takashi Koyama, Susumu Ikehara
Large-cell neuroendocrine carcinoma (LCNEC) of the endometrium is an extremely rare, high-grade malignant tumor. We herein report a case of a rapidly growing LCNEC arising in the endometrium. A 52-year-old woman was referred to Toyooka Hospital (Tooyoka, Japan) due to genital bleeding in February 2016. There had been no abnormalities on a regular gynecological and physical examination 3 months prior to the consultation. Imaging (computed tomography and magnetic resonance imaging) and a pelvic examination revealed a tumor sized 16...
April 2018: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/29531007/uterus-septus-subtotalis-bicollis-a-rare-mullerian-duct-abnormality
#18
Paloma Del C Monroig-Bosque, Ekene I Okoye
Mullerian duct anomalies (MDAs) are congenital defects of the female genital system that arise from abnormal embryological development of the Mullerian ducts. Septate uterus is the most common, resulting from incomplete resorption of the medial septum after fusion of the Mullerian ducts. Two main types of septate uterus exist, including septa that extend completely or partially from the uterine fundus to the cervical os. The combination of a uterine septum with a double cervix has been previously described; however, in most cases the septum was complete...
January 2018: Annals of Clinical and Laboratory Science
https://www.readbyqxmd.com/read/29520664/association-between-genital-mycoplasmas-infection-and-human-papillomavirus-infection-abnormal-cervical-cytopathology-and-cervical-cancer-a-systematic-review-and-meta-analysis
#19
REVIEW
Hui Ye, Tiange Song, Xi Zeng, Lin Li, Minmin Hou, Mingrong Xi
BACKGROUND: Some studies demonstrated that female genital mycoplasmas play important roles in human papillomavirus (HPV) infection, abnormal cervical cytopathology, and cervical cancer. However, those results remained inconclusive. We aimed to perform a systematic review and meta-analysis to investigate the association between female genital mycoplasmas and those disorders. METHODS: Computerized databases were comprehensively searched before 26 January 2017. Pooled odd radios (ORs) and correlative 95% confidence intervals (CIs) were adopted to evaluate the strength of association...
June 2018: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/29516876/chronic-epididymitis-and-grade-iii-varicocele-and-their-associations-with-semen-characteristics-in-men-consulting-for-couple-infertility
#20
Alejandro Oliva, Luc Multigner
Chronic epididymitis and varicocele are frequently observed genital disorders in men consulting for couple infertility, but their impact on semen characteristics at the time of infertility consultation is still a matter of debate. We investigated 652 male partners of couples who had their first infertility consultation between 1999 and 2015 in Argentina. Men with chronic epididymitis (n = 253), Grade III varicocele (n = 106), and both conditions (n = 125) were compared with a control group (n = 168) composed of men without these disorders or any other recognized causes of male infertility...
March 6, 2018: Asian Journal of Andrology
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