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https://www.readbyqxmd.com/read/28730671/many-faces-of-rationality-implications-of-the-great-rationality-debate-for-clinical-decision-making
#1
Benjamin Djulbegovic, Shira Elqayam
Given that more than 30% of healthcare costs are wasted on inappropriate care, suboptimal care is increasingly connected to the quality of medical decisions. It has been argued that personal decisions are the leading cause of death, and 80% of healthcare expenditures result from physicians' decisions. Therefore, improving healthcare necessitates improving medical decisions, ie, making decisions (more) rational. Drawing on writings from The Great Rationality Debate from the fields of philosophy, economics, and psychology, we identify core ingredients of rationality commonly encountered across various theoretical models...
July 20, 2017: Journal of Evaluation in Clinical Practice
https://www.readbyqxmd.com/read/28725296/revisiting-folk-moral-realism
#2
Thomas Pölzler
Moral realists believe that there are objective moral truths. According to one of the most prominent arguments in favour of this view, ordinary people experience morality as realist-seeming, and we have therefore prima facie reason to believe that realism is true. Some proponents of this argument have claimed that the hypothesis that ordinary people experience morality as realist-seeming is supported by psychological research on folk metaethics. While most recent research has been thought to contradict this claim, four prominent earlier studies (by Goodwin and Darley, Wainryb et al...
2017: Review of Philosophy and Psychology
https://www.readbyqxmd.com/read/28714711/children-understand-that-agents-maximize-expected-utilities
#3
Julian Jara-Ettinger, Sammy Floyd, Joshua B Tenenbaum, Laura E Schulz
A growing set of studies suggests that our ability to infer, and reason about, mental states is supported by the assumption that agents maximize utilities-the rewards they attain minus the costs they incur. This assumption enables observers to work backward from agents' observed behavior to their underlying beliefs, preferences, and competencies. Intuitively, however, agents may have incomplete, uncertain, or wrong beliefs about what they want. More formally, agents try to maximize their expected utilities...
July 17, 2017: Journal of Experimental Psychology. General
https://www.readbyqxmd.com/read/28709305/information-trimming-sufficient-statistics-mutual-information-and-predictability-from-effective-channel-states
#4
Ryan G James, John R Mahoney, James P Crutchfield
One of the most basic characterizations of the relationship between two random variables, X and Y, is the value of their mutual information. Unfortunately, calculating it analytically and estimating it empirically are often stymied by the extremely large dimension of the variables. One might hope to replace such a high-dimensional variable by a smaller one that preserves its relationship with the other. It is well known that either X (or Y) can be replaced by its minimal sufficient statistic about Y (or X) while preserving the mutual information...
June 2017: Physical Review. E
https://www.readbyqxmd.com/read/28686588/inherent-limitations-of-probabilistic-models-for-protein-dna-binding-specificity
#5
Shuxiang Ruan, Gary D Stormo
The specificities of transcription factors are most commonly represented with probabilistic models. These models provide a probability for each base occurring at each position within the binding site and the positions are assumed to contribute independently. The model is simple and intuitive and is the basis for many motif discovery algorithms. However, the model also has inherent limitations that prevent it from accurately representing true binding probabilities, especially for the highest affinity sites under conditions of high protein concentration...
July 2017: PLoS Computational Biology
https://www.readbyqxmd.com/read/28671478/a-qualitative-study-exploring-factors-influencing-clinical-decision-making-for-influenza-like-illness-in-solapur-city-maharashtra-india
#6
A S Ahankari, P R Myles, S Tsang, F Khan, S Atre, T Langley, A Kudale, M Bains
The co-existence of different types of medical systems (medical pluralism) is a typical feature of India's healthcare system. For conditions such as influenza-like illness (ILI), where non-specific disease signs/symptoms exist, clinical reasoning in the context of medical pluralism becomes crucial. Recognising this need, we undertook a qualitative study, which explored factors underpinning clinical decisions on diagnosis and management of ILI. The study involved semi-structured interviews including clinical vignettes with 20 healthcare practitioners (working within allopathy, homeopathy and Ayurveda) working in the private healthcare sector in Solapur city, India...
July 3, 2017: Anthropology & Medicine
https://www.readbyqxmd.com/read/28658946/heating-enhanced-dielectrophoresis-for-aligned-single-walled-carbon-nanotube-film-of-ultrahigh-density
#7
Qingyuan Gu, Maud Guezo, Hervé Folliot, Thomas Batte, Slimane Loualiche, Julie Stervinou
In this paper, we demonstrate that the alignment density of individualized single-walled carbon nanotubes (SWCNTs) can be greatly improved by heating-enhanced dielectrophoresis (HE-DEP) process. The observations by scanning electron microscope (SEM) suggest ultrahigh alignment density and good alignment quality of SWCNTs. The intuitive alignment density of individualized SWCNTs is much higher than the currently reported best results. The reason of this HE-DEP process is explained by simulation work and ascribed to the heating-enhanced convection process, and the "convection force" induced by the heating effect is assessed in a novel way...
December 2017: Nanoscale Research Letters
https://www.readbyqxmd.com/read/28657313/novel-methods-for-prioritizing-close-in-analogs-from-structure-activity-relationship-matrices
#8
Liying Zhang, Kjell Johnson, Jeremy Starr, Jared Milbank, Andrew M Kuhn, Christopher Poss, Robert V Stanton, Veerabahu Shanmugasundaram
Here we describe the development of novel methods for compound evaluation and prioritization based on the structure-activity relationship matrix (SARM) framework. The SARM data structure allows automatic and exhaustive extraction of SAR patterns from data sets and their organization into a chemically intuitive scaffold/functional-group format. While SARMs have been used in the retrospective analysis of SAR discontinuity and identifying underexplored regions of chemistry space, there have been only a few attempts to apply SARMs prospectively in the prioritization of "close-in" analogs...
July 13, 2017: Journal of Chemical Information and Modeling
https://www.readbyqxmd.com/read/28651546/allocating-health-care-resources-a-questionnaire-experiment-on-the-predictive-success-of-rules
#9
Marlies Ahlert, Lars Schwettmann
BACKGROUND: The topic of this paper is related to equity in health within a country. In public health care sectors of many countries decisions on priority setting with respect to treatment of different types of diseases or patient groups are implicitly or explicitly made. Priorities are realized by allocation decisions for medical resources where moral judgments play an important role with respect to goals and measures that should be applied. The aim of this study is to explore the moral intuitions held in the German society related to priorities in medical treatment...
June 26, 2017: International Journal for Equity in Health
https://www.readbyqxmd.com/read/28629648/ten-reasons-to-embrace-scientism
#10
Rik Peels
A strong version of scientism, such as that of Alex Rosenberg, says, roughly, that natural science reliably delivers rational belief or knowledge, whereas common sense sources of belief, such as moral intuition, memory, and introspection, do not. In this paper I discuss ten reasons that adherents of scientism have or might put forward in defence of scientism. The aim is to show which considerations could plausibly count in favour of scientism and what this implies for the way scientism ought to be formulated...
June 2017: Studies in History and Philosophy of Science
https://www.readbyqxmd.com/read/28582254/studies-involving-people-with-dementia-and-touchscreen-technology-a-literature-review
#11
REVIEW
Phil Joddrell, Arlene J Astell
BACKGROUND: Devices using touchscreen interfaces such as tablets and smartphones have been highlighted as potentially suitable for people with dementia due to their intuitive and simple control method. This population experience a lack of meaningful, engaging activities, yet the potential use of the touchscreen format to address this issue has not been fully realized. OBJECTIVE: To identify and synthesize the existing body of literature involving the use of touchscreen technology and people with dementia in order to guide future research in this area...
November 4, 2016: JMIR Rehabil Assist Technol
https://www.readbyqxmd.com/read/28558050/citizen-science-a-new-perspective-to-advance-spatial-pattern-evaluation-in-hydrology
#12
Julian Koch, Simon Stisen
Citizen science opens new pathways that can complement traditional scientific practice. Intuition and reasoning often make humans more effective than computer algorithms in various realms of problem solving. In particular, a simple visual comparison of spatial patterns is a task where humans are often considered to be more reliable than computer algorithms. However, in practice, science still largely depends on computer based solutions, which inevitably gives benefits such as speed and the possibility to automatize processes...
2017: PloS One
https://www.readbyqxmd.com/read/28557945/how-entrustment-is-informed-by-holistic-judgments-across-time-in-a-family-medicine-residency-program-an-ethnographic-nonparticipant-observational-study
#13
Margaretha H Sagasser, Cornelia R M G Fluit, Chris van Weel, Cees P M van der Vleuten, Anneke W M Kramer
PURPOSE: Entrustment has mainly been conceptualized as delegating discrete professional tasks. Because residents provide most of their patient care independently, not all resident performance is visible to supervisors; the entrustment process involves more than granting discrete tasks. This study explored how supervisors made entrustment decisions based on residents' performance in a long-term family medicine training program. METHOD: A qualitative nonparticipant observational study was conducted in 2014-2015 at competency-based family medicine residency programs in the Netherlands...
June 2017: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/28554318/anti-cancer-compounds-targeted-to-vdac-potential-and-perspectives
#14
Simona Reina, Vito De Pinto
VDAC (Voltage-Dependent Anion selective Channel) is a small family of abundant pore-forming proteins located in the outer mitochondrial membrane. Their role range from the most intuitive, the formation of a hydrophilic conduit through the membrane thanks to its beta-barrel structure, to less understood functions that make them essential actors in the cross-talk between the bioenergetics metabolism and the cytosol components. Due to this localization, VDAC1, in particular, has been reported to be involved in apoptosis, hexokinase and tubulin binding, and in the Warburg effect...
May 29, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28544082/a-resource-of-potential-drug-targets-and-strategic-decision-making-for-obstructive-sleep-apnoea-pharmacotherapy
#15
REVIEW
Richard L Horner, Kevin P Grace, Andrew Wellman
There is currently no pharmacotherapy for obstructive sleep apnoea (OSA) but there is no principled a priori reason why there should not be one. This review identifies a rational decision-making strategy with the necessary logical underpinnings that any reasonable approach would be expected to navigate to develop a viable pharmacotherapy for OSA. The process first involves phenotyping an individual to quantify and characterize the critical predisposing factor(s) to their OSA pathogenesis and identify, a priori, if the patient is likely to benefit from a pharmacotherapy that targets those factors...
July 2017: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/28537565/surrogate-and-clinical-endpoints-for-studies-in-peripheral-artery-occlusive-disease-are-statistics-the-brakes
#16
Matthias W Waliszewski, Ulf Redlich, Victor Breul, Jörg Tautenhahn
BACKGROUND: The aim of this review is to present the available clinical and surrogate endpoints that may be used in future studies performed in patients with peripheral artery occlusive disease (PAOD). Importantly, we describe statistical limitations of the most commonly used endpoints and offer some guidance with respect to study design for a given sample size. The proposed endpoints may be used in studies using surgical or interventional revascularization and/or drug treatments. METHODS: Considering recently published study endpoints and designs, the usefulness of these endpoints for reimbursement is evaluated...
April 30, 2017: Polski Przeglad Chirurgiczny
https://www.readbyqxmd.com/read/28536918/-cognitive-errors-in-diagnostic-decision-making
#17
REVIEW
Martin Gäbler
Approximately 10-15% of our diagnostic decisions are faulty and may lead to unfavorable and dangerous outcomes, which could be avoided. These diagnostic errors are mainly caused by cognitive biases in the diagnostic reasoning process.Our medical diagnostic decision-making is based on intuitive "System 1" and analytical "System 2" diagnostic decision-making and can be deviated by unconscious cognitive biases.These deviations can be positively influenced on a systemic and an individual level. For the individual, metacognition (internal withdrawal from the decision-making process) and debiasing strategies, such as verification, falsification and rule out worst-case scenarios, can lead to improved diagnostic decisions making...
May 23, 2017: Wiener Medizinische Wochenschrift
https://www.readbyqxmd.com/read/28512524/promoting-the-multidimensional-character-of-scientific-reasoning
#18
William S Bradshaw, Jennifer Nelson, Byron J Adams, John D Bell
This study reports part of a long-term program to help students improve scientific reasoning using higher-order cognitive tasks set in the discipline of cell biology. This skill was assessed using problems requiring the construction of valid conclusions drawn from authentic research data. We report here efforts to confirm the hypothesis that data interpretation is a complex, multifaceted exercise. Confirmation was obtained using a statistical treatment showing that various such problems rank students differently-each contains a unique set of cognitive challenges...
April 2017: Journal of Microbiology & Biology Education: JMBE
https://www.readbyqxmd.com/read/28504021/the-theory-of-dyadic-morality-reinventing-moral-judgment-by-redefining-harm
#19
Chelsea Schein, Kurt Gray
The nature of harm-and therefore moral judgment-may be misunderstood. Rather than an objective matter of reason, we argue that harm should be redefined as an intuitively perceived continuum. This redefinition provides a new understanding of moral content and mechanism-the constructionist Theory of Dyadic Morality (TDM). TDM suggests that acts are condemned proportional to three elements: norm violations, negative affect, and-importantly-perceived harm. This harm is dyadic, involving an intentional agent causing damage to a vulnerable patient (A→P)...
May 1, 2017: Personality and Social Psychology Review
https://www.readbyqxmd.com/read/28500981/some-consequences-of-normal-aging-for-generating-conceptual-explanations-a-case-study-of-vitalist-biology
#20
Nathan Tardiff, Igor Bascandziev, Kaitlin Sandor, Susan Carey, Deborah Zaitchik
Accumulating evidence suggests that not only diseases of old age, but also normal aging, affect elderly adults' ability to draw on the framework theories that structure our abstract causal-explanatory knowledge, knowledge that we use to make sense of the world. One such framework theory, the cross-culturally universal vitalist biology, gives meaning to the abstract concepts life and death. Previous work shows that many elderly adults are animists, claiming that active, moving entities such as the sun and the wind are alive (Zaitchik & Solomon, 2008)...
June 2017: Cognitive Psychology
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