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https://www.readbyqxmd.com/read/29074496/treatment-of-advanced-glaucoma-study-a-multicentre-randomised-controlled-trial-comparing-primary-medical-treatment-with-primary-trabeculectomy-for-people-with-newly-diagnosed-advanced-glaucoma-study-protocol
#1
Anthony J King, Gordon Fernie, Augusto Azuara-Blanco, Jennifer M Burr, Ted Garway-Heath, John M Sparrow, Luke Vale, Jemma Hudson, Graeme MacLennan, Alison McDonald, Keith Barton, John Norrie
BACKGROUND: Presentation with advanced glaucoma is the major risk factor for lifetime blindness. Effective intervention at diagnosis is expected to minimise risk of further visual loss in this group of patients. AIM: To compare clinical and cost-effectiveness of primary medical management compared with primary surgery for people presenting with advanced open-angle glaucoma (OAG). METHODS: Design: A prospective, pragmatic multicentre randomised controlled trial (RCT)...
October 26, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28937506/role-of-lens-extraction-and-laser-peripheral-iridotomy-in-treatment-of-glaucoma
#2
Sara Pose-Bazarra, Augusto Azuara-Blanco
PURPOSE OF REVIEW: Lens extraction in people with coexisting cataract and open angle glaucoma is associated with a reduction in intraocular pressure (IOP). In primary angle-closure glaucoma (PACG), lens extraction and laser peripheral iridotomy (LPI) can be used to open the anterior chamber angle, increase the outflow through the trabecular meshwork and reduce the IOP. The present review will summarize the recent available literature regarding the role of both interventions for the treatment of glaucoma...
September 20, 2017: Current Opinion in Ophthalmology
https://www.readbyqxmd.com/read/28920761/can-ultra-wide-field-retinal-imaging-replace-colour-digital-stereoscopy-for-glaucoma-detection
#3
Nicola B Quinn, Augusto Azuara-Blanco, Katie Graham, Ruth E Hogg, Ian S Young, Frank Kee
PURPOSE: Ultra-wide field (UWF) retinal imaging (Optomap, Optos plc, Dunfermline, UK) is a novel technique to image the peripheral fundus. The goal of this study was to explore the potential use of UWF imaging to detect glaucoma, and specifically to evaluate the reproducibility of measures of vertical cup-to-disc ratio (VCDR) using ultra-wide field (UWF), and the agreement between UWF and standard colour digital stereoscopy (CDS). METHODS: An observational study...
September 18, 2017: Ophthalmic Epidemiology
https://www.readbyqxmd.com/read/28855198/diagnostic-accuracy-of-optical-coherence-tomography-for-diagnosing-glaucoma-secondary-analyses-of-the-gate-study
#4
Gianni Virgili, Manuele Michelessi, Jonathan Cook, Charles Boachie, Jennifer Burr, Katie Banister, David F Garway-Heath, Rupert R A Bourne, Almudena Asorey Garcia, Craig R Ramsay, Augusto Azuara-Blanco
BACKGROUND/AIMS: To assess the diagnostic performance of retinal nerve fibre layer (RNFL) data of optical coherence tomography (OCT) for detecting glaucoma. METHODS: Secondary analyses of a prospective, multicentre diagnostic study (Glaucoma Automated Tests Evaluation (GATE)) referred to hospital eye services in the UK were conducted. We included data from 899 of 966 participants referred to hospital eye services with suspected glaucoma or ocular hypertension. We used both eyes' data and logistic regression-based receiver operator characteristics analysis to build a set of models to measure the sensitivity and specificity of the average and inferior quadrant RNFL thickness data of OCT...
August 30, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28821554/developing-standards-for-the-development-of-glaucoma-virtual-clinics-using-a-modified-delphi-approach
#5
Aachal Kotecha, Simon Longstaff, Augusto Azuara-Blanco, James F Kirwan, James Edwards Morgan, Anne Fiona Spencer, Paul J Foster
PURPOSE: To obtain consensus opinion for the development of a standards framework for the development and implementation of virtual clinics for glaucoma monitoring in the UK using a modified Delphi methodology. METHODS: A modified Delphi technique was used that involved sampling members of the UK Glaucoma and Eire Society (UKEGS). The first round scored the strength of agreement to a series of standards statements using a 9-point Likert scale. The revised standards were subjected to a second round of scoring and free-text comment...
August 18, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28794074/the-incidence-of-acute-angle-closure-in-scotland-a-prospective-surveillance-study
#6
Paul Y Chua, Alexander C Day, Ken L Lai, Nikki Hall, Lai L Tan, Kamran Khan, Lik Thai Lim, Barny Foot, Paul J Foster, Augusto Azuara-Blanco
PURPOSE: To estimate the incidence, and describe the clinical features and short-term clinical outcomes of acute angle closure (AAC). METHODS: Patients with newly diagnosed AAC were identified prospectively over a 12-month period (November 2011 to October 2012) by active surveillance through the Scottish Ophthalmic Surveillance Unit reporting system. Data were collected at case identification and at 6 months follow-up. RESULTS: There were 114 cases (108 patients) reported, giving an annual incidence of 2...
August 9, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28522116/a-new-approach-for-the-management-of-primary-angle-closure-glaucoma-after-eagle-trial
#7
F J Muñoz Negrete, A Azuara-Blanco
No abstract text is available yet for this article.
May 15, 2017: Archivos de la Sociedad Española de Oftalmología
https://www.readbyqxmd.com/read/28315873/clear-lens-extraction-for-early-angle-closure-glaucoma-revolution-or-overtreatment
#8
Ke Shi, Zhipeng You, Changyun Wang
No abstract text is available yet for this article.
2017: Medical Principles and Practice: International Journal of the Kuwait University, Health Science Centre
https://www.readbyqxmd.com/read/28114574/author-response-statin-use-and-open-angle-glaucoma-evidence-from-observational-studies
#9
Paul McCann, Ruth E Hogg, Augusto Azuara-Blanco
No abstract text is available yet for this article.
January 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28102642/glaucoma-blindness-at-the-end-of-life
#10
EDITORIAL
Palwasha Mokhles, Jan Sag Schouten, Henny Jm Beckers, Augusto Azuara-Blanco, Anja Tuulonen, Carroll Ab Webers
No abstract text is available yet for this article.
February 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/28087548/early-lens-extraction-with-intraocular-lens-implantation-for-the-treatment-of-primary-angle-closure-glaucoma-an-economic-evaluation-based-on-data-from-the-eagle-trial
#11
Mehdi Javanbakht, Augusto Azuara-Blanco, Jennifer M Burr, Craig Ramsay, David Cooper, Claire Cochran, John Norrie, Graham Scotland
OBJECTIVE: To investigate the cost-effectiveness of early lens extraction with intraocular lens implantation for the treatment of primary angle closure glaucoma (PACG) compared to standard care. DESIGN: Cost-effectiveness analysis alongside a multicentre pragmatic two-arm randomised controlled trial. Patients were followed-up for 36 months, and data on health service usage and health state utility were collected and analysed within the trial time horizon. A Markov model was developed to extrapolate the results over a 5-year and 10-year time horizon...
January 13, 2017: BMJ Open
https://www.readbyqxmd.com/read/27726283/survey-of-glaucoma-surgical-preferences-and-post-operative-care-in-the-united-kingdom
#12
Ignacio Rodriguez-Una, Augusto Azuara-Blanco, Anthony J King
BACKGROUND: To evaluate the spectrum of glaucoma surgery and the post-operative follow-up regimes undertaken among glaucoma specialists in the United Kingdom. DESIGN: National survey. PARTICIPANTS: Seventy-five glaucoma specialists (consultants and fellows). METHODS: An eight-question survey was emailed to all glaucoma subspecialists members of the United Kingdom and Eire Glaucoma Society. MAIN OUTCOME MEASURES: Surgery undertaken, post-operative management, awareness of intervention tariff and handling of the follow-up burden generated through surgery...
April 2017: Clinical & Experimental Ophthalmology
https://www.readbyqxmd.com/read/27707497/effectiveness-of-early-lens-extraction-for-the-treatment-of-primary-angle-closure-glaucoma-eagle-a-randomised-controlled-trial
#13
COMMENT
Augusto Azuara-Blanco, Jennifer Burr, Craig Ramsay, David Cooper, Paul J Foster, David S Friedman, Graham Scotland, Mehdi Javanbakht, Claire Cochrane, John Norrie
BACKGROUND: Primary angle-closure glaucoma is a leading cause of irreversible blindness worldwide. In early-stage disease, intraocular pressure is raised without visual loss. Because the crystalline lens has a major mechanistic role, lens extraction might be a useful initial treatment. METHODS: From Jan 8, 2009, to Dec 28, 2011, we enrolled patients from 30 hospital eye services in five countries. Randomisation was done by a web-based application. Patients were assigned to undergo clear-lens extraction or receive standard care with laser peripheral iridotomy and topical medical treatment...
October 1, 2016: Lancet
https://www.readbyqxmd.com/read/27196321/the-effect-of-statins-on-intraocular-pressure-and-on-the-incidence-and-progression-of-glaucoma-a-systematic-review-and-meta-analysis
#14
REVIEW
Paul McCann, Ruth E Hogg, Richard Fallis, Augusto Azuara-Blanco
PURPOSE: We conducted a systematic review and meta-analysis of observational studies to evaluate the effect of oral statins on intraocular pressure (IOP) and the incidence and progression of glaucoma. METHODS: This was a systematic review of the literature and meta-analysis. Searches of PubMed/Medline and Embase were conducted to include all types of studies. Gray literature abstracts were also considered for inclusion. Last search date was February 2016. Risk of bias was assessed using the Newcastle-Ottawa scale independently by two reviewers...
May 1, 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/27016459/can-automated-imaging-for-optic-disc-and-retinal-nerve-fiber-layer-analysis-aid-glaucoma-detection
#15
COMPARATIVE STUDY
Katie Banister, Charles Boachie, Rupert Bourne, Jonathan Cook, Jennifer M Burr, Craig Ramsay, David Garway-Heath, Joanne Gray, Peter McMeekin, Rodolfo Hernández, Augusto Azuara-Blanco
PURPOSE: To compare the diagnostic performance of automated imaging for glaucoma. DESIGN: Prospective, direct comparison study. PARTICIPANTS: Adults with suspected glaucoma or ocular hypertension referred to hospital eye services in the United Kingdom. METHODS: We evaluated 4 automated imaging test algorithms: the Heidelberg Retinal Tomography (HRT; Heidelberg Engineering, Heidelberg, Germany) glaucoma probability score (GPS), the HRT Moorfields regression analysis (MRA), scanning laser polarimetry (GDx enhanced corneal compensation; Glaucoma Diagnostics (GDx), Carl Zeiss Meditec, Dublin, CA) nerve fiber indicator (NFI), and Spectralis optical coherence tomography (OCT; Heidelberg Engineering) retinal nerve fiber layer (RNFL) classification...
May 2016: Ophthalmology
https://www.readbyqxmd.com/read/26900829/a-systematic-review-of-end-of-life-visual-impairment-in-open-angle-glaucoma-an-epidemiological-autopsy
#16
REVIEW
Palwasha Mokhles, Jan S A G Schouten, Henny J M Beckers, Augusto Azuara-Blanco, Anja Tuulonen, Carroll A B Webers
PURPOSE: Glaucoma patients are still at risk of becoming blind. It is of clinical significance to determine the risk of blindness and its causes to prevent its occurrence. This systematic review estimates the number of treated glaucoma patients with end-of-life visual impairment (VI) and blindness and the factors that are associated with this. METHODS: A systematic literature search in relevant databases was conducted in August 2014 on end-of-life VI. A total of 2574 articles were identified, of which 5 on end-of-life VI...
July 2016: Journal of Glaucoma
https://www.readbyqxmd.com/read/26822760/automated-imaging-technologies-for-the-diagnosis-of-glaucoma-a-comparative-diagnostic-study-for-the-evaluation-of-the-diagnostic-accuracy-performance-as-triage-tests-and-cost-effectiveness-gate-study
#17
COMPARATIVE STUDY
Augusto Azuara-Blanco, Katie Banister, Charles Boachie, Peter McMeekin, Joanne Gray, Jennifer Burr, Rupert Bourne, David Garway-Heath, Mark Batterbury, Rodolfo Hernández, Gladys McPherson, Craig Ramsay, Jonathan Cook
BACKGROUND: Many glaucoma referrals from the community to hospital eye services are unnecessary. Imaging technologies can potentially be useful to triage this population. OBJECTIVES: To assess the diagnostic performance and cost-effectiveness of imaging technologies as triage tests for identifying people with glaucoma. DESIGN: Within-patient comparative diagnostic accuracy study. Markov economic model comparing the cost-effectiveness of a triage test with usual care...
January 2016: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/26659710/monitoring-ocular-hypertension-how-much-and-how-often-a-cost-effectiveness-perspective
#18
MULTICENTER STUDY
R Hernández, J M Burr, L Vale, A Azuara-Blanco, J A Cook, K Banister, A Tuulonen, M Ryan
OBJECTIVE: To assess the efficiency of alternative monitoring services for people with ocular hypertension (OHT), a glaucoma risk factor. DESIGN: Discrete event simulation model comparing five alternative care pathways: treatment at OHT diagnosis with minimal monitoring; biennial monitoring (primary and secondary care) with treatment if baseline predicted 5-year glaucoma risk is ≥6%; monitoring and treatment aligned to National Institute for Health and Care Excellence (NICE) glaucoma guidance (conservative and intensive)...
September 2016: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/26206532/design-characteristic-of-randomised-controlled-trials-for-geographic-atrophy-in-age-related-macular-degeneration-selection-of-outcomes-and-sample-size-calculation
#19
REVIEW
A K Krezel, R E Hogg, S Krezel, R Fallis, A Azuara-Blanco
PURPOSE: The selection of suitable outcomes and sample size calculation are critical factors in the design of a randomised controlled trial (RCT). The goal of this study was to identify the range of outcomes and information on sample size calculation in RCTs on geographic atrophy (GA). METHODS: We carried out a systematic review of age-related macular degeneration (AMD) RCTs. We searched MEDLINE, EMBASE, Scopus, Cochrane Library, www.controlled-trials.com, and www...
November 2015: Eye
https://www.readbyqxmd.com/read/26091178/consensus-on-outcome-measures-for-glaucoma-effectiveness-trials-results-from-a-delphi-and-nominal-group-technique-approaches
#20
MULTICENTER STUDY
Rehab Ismail, Augusto Azuara-Blanco, Craig R Ramsay
PURPOSE: Comparing the relative effectiveness of interventions across glaucoma trials can be problematic due to differences in definitions of outcomes. We sought to identify a key set of clinical outcomes and reach consensus on how best to measure them from the perspective of glaucoma experts. METHODS: A 2-round electronic Delphi survey was conducted. Round 1 involved 25 items identified from a systematic review. Round 2 was developed based on information gathered in round 1...
June 2016: Journal of Glaucoma
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