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https://www.readbyqxmd.com/read/29781625/vertically-emitting-indium-phosphide-nanowire-lasers
#1
Wei-Zong Xu, Fang-Fang Ren, Dimitars Jevtics, Antonio Hurtado, Li Li, Qian Gao, Jiandong Ye, Fan Wang, Benoit Guilhabert, Lan Fu, Hai Lu, Rong Zhang, Hark Hoe Tan, Martin Dawson, Chennupati Jagadish
Semiconductor nanowire (NW) lasers have attracted considerable research effort given their excellent promise for nanoscale photonic sources. However, NW lasers currently exhibit poor directionality and high threshold gain, issues critically limiting their prospects for on-chip light sources with extremely reduced footprint and efficient power consumption. Here, we propose a new design and experimentally demonstrate a vertically emitting indium phosphide (InP) NW laser structure showing high emission directionality and reduced energy requirements for operation...
May 21, 2018: Nano Letters
https://www.readbyqxmd.com/read/29781154/neuroglial-ectopia-of-the-vestibular-nerve-masquerading-as-a-vestibular-schwannoma-a-case-report
#2
John P Sheppard, Carlito Lagman, Thien Nguyen, Négar Khanlou, Quinton Gopen, Isaac Yang
Neuroglial ectopia is a rare entity of undetermined clinical significance. Here, we report a unique case of neuroglial ectopia of the vestibular nerve. A 27-year-old pharmacy student with a previous radiological diagnosis of vestibular schwannoma presented to our clinic for surgical evaluation. Magnetic resonance imaging (MRI) of the brain revealed a 17-mm T1 hypo- to isointense, T2 iso- to hyperintense, poorly enhancing left cerebellopontine angle mass extending into the left internal auditory canal compatible by imaging with a vestibular schwannoma...
May 20, 2018: Neuropathology: Official Journal of the Japanese Society of Neuropathology
https://www.readbyqxmd.com/read/29780209/near-infrared-fluorescence-image-guidance-in-plastic-surgery-a-systematic-review
#3
REVIEW
Anouk J M Cornelissen, Tom J M van Mulken, Caitlin Graupner, Shan S Qiu, Xavier H A Keuter, René R W J van der Hulst, Rutger M Schols
Background: Near-infrared fluorescence (NIRF) imaging technique, after administration of contrast agents with fluorescent characteristics in the near-infrared (700-900 nm) range, is considered to possess great potential for the future of plastic surgery, given its capacity for perioperative, real-time anatomical guidance and identification. This study aimed to provide a comprehensive literature review concerning current and potential future applications of NIRF imaging in plastic surgery, thereby guiding future research...
2018: European Journal of Plastic Surgery
https://www.readbyqxmd.com/read/29778401/high-intensity-focused-ultrasound-the-fundamentals-clinical-applications-and-research-trends
#4
I A Shehata Elhelf, H Albahar, U Shah, A Oto, E Cressman, M Almekkawy
Diagnostic ultrasound has been clinically used for decades. More recently, high intensity focused ultrasound (HIFU) has been developed for therapeutic use as a non-invasive technique for tissue ablation. HIFU is also being investigated for advanced applications at the cellular level. Under guidance by magnetic resonance or ultrasound imaging, HIFU can achieve precise biological effects in tissue with a high safety profile. In this article, we discuss the basic principles, advantages and limitations of HIFU...
May 17, 2018: Diagnostic and Interventional Imaging
https://www.readbyqxmd.com/read/29778317/appropriate-use-of-noninvasive-ischemia-testing-to-guide-revascularization-decision-making-following-acute-st-elevation-myocardial-infarction-in-latin-american-countries-results-from-an-expert-panel-meeting-of-the-international-atomic-energy-agency
#5
I Berrocal, A Peix, F Mut, L J Shaw, G Karthikeyan, E Estrada Lobato, D Paez
Across Latin American and Caribbean countries, cardiovascular disease and especially ischemic heart disease is currently the main cause of death both in men and in women. For most Latin American and Caribbean countries, public and community health efforts aim to define care strategies which are both clinically and cost effective and promote primary and secondary prevention, resulting in improved patient outcomes. The optimal approach to deal with acute events such as ST-elevation myocardial infarction (STEMI) is a matter of controversy; however, there is an expanding role for assessing residual ischemic burden in STEMI patients following primary percutaneous coronary intervention...
May 16, 2018: Revista Española de Medicina Nuclear e Imagen Molecular
https://www.readbyqxmd.com/read/29777008/multispectral-fluorescence-imaging-as-a-tool-to-separate-healthy-and-disease-related-lymphatic-anatomies-during-robot-assisted-laparoscopic-procedures
#6
Philippa Meershoek, Gijs H KleinJan, Matthias N van Oosterom, Esther M Wit, Danny M van Willigen, Kevin P Bauwens, Erik J van Gennep, Alexandre M Mottrie, Henk G van der Poel, Fijs van Leeuwen
To reduce the invasive nature of extended pelvic lymph node dissections (ePLND) in prostate cancer, we have developed a multicolor fluorescence guidance approach that enables the discrimination between prostate draining lymph nodes (LNs) and lower limb draining LNs. Methods: In five porcine models multispectral-fluorescence guidance was performed using da Vinci Si- and Xi-robot consoles. They received fluorescein into the lower limb(s) and indocyanine green (ICG)-nanocolloid into the prostate. Results: Fluorescein was detected in 29 LNs (average of 3...
May 18, 2018: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/29776790/-modern-treatment-of-mesenteric-ischemia
#7
Alexandre Nuzzo, Audrey Huguet, Olivier Corcos
Acute mesenteric ischemia is a highly morbid affliction which requires urgent care. Acute mesenteric ischemia consists in an ischemia injury of the small bowel, secondary to vascular insufficiency, either occlusive (thrombosis, embolism, arterial, venous) or non-occlusive (low flow or vasospasm). Given that the superior mesenteric artery supplies the small bowel as well as the right part of the colon, any ischemic process involving the right colon should be considered an acute mesenteric ischemia until proven otherwise...
May 15, 2018: La Presse Médicale
https://www.readbyqxmd.com/read/29774064/tumour-homing-chimeric-polypeptide-conjugated-polypyrrole-nanoparticles-for-imaging-guided-synergistic-photothermal-and-chemical-therapy-of-cancer
#8
Mengmeng Sun, Jianwen Guo, Hanjun Hao, Tong Tong, Kun Wang, Weiping Gao
Near-infrared (NIR)-absorbing conjugated polymer nanoparticles are interesting for imaging-guided combination therapy, especially for synergistic photothermal therapy and chemotherapy; however, most of them target tumours passively through the enhanced permeability and retention (EPR) effect, leading to low utilization efficiency. To address this problem, we report an active tumour-targeting strategy of tumour-homing chimeric polypeptide-conjugated NIR-absorbing conjugated-polymer nanoparticles as a new class of drug nanocarriers for imaging-guided combination therapy of cancer...
2018: Theranostics
https://www.readbyqxmd.com/read/29773582/activation-of-large-conductance-calcium-activated-k-channels-by-nitric-oxide-mediates-apelin-induced-relaxation-of-coronary-arteries
#9
Amreen Mughal, Chengwen Sun, Stephen T O'Rourke
Apelin increases coronary blood flow, cardiac contractility and cardiac output. Based on these favorable hemodynamic effects, apelin and apelin-like analogs are being developed for treating heart failure and related disorders; however, the molecular mechanisms underlying apelin-induced coronary vasodilation are unknown. This study aimed to elucidate the signaling pathways by which apelin causes smooth muscle relaxation in coronary arteries. Receptors for apelin (APJ receptors) were expressed in coronary arteries, as determined by Western blot and PCR analyses...
May 17, 2018: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/29773331/novel-use-of-viewray-mri-guidance-for-high-dose-rate-brachytherapy-in-the-treatment-of-cervical-cancer
#10
Huaising C Ko, Jessie Y Huang, Jessica R Miller, Rupak K Das, Charles R Wallace, Anna-Maria A De Costa, David M Francis, Margaret R Straub, Bethany M Anderson, Kristin A Bradley
PURPOSE: To characterize image quality and feasibility of using ViewRay MRI (VR)-guided brachytherapy planning for cervical cancer. METHODS AND MATERIALS: Cervical cancer patients receiving intracavitary brachytherapy with tandem and ovoids, planned using 0.35T VR MRI at our institution, were included in this series. The high-risk clinical target volume (HR-CTV), visible gross tumor volume, bladder, sigmoid, bowel, and rectum contours for each fraction of brachytherapy were evaluated for dosimetric parameters...
May 14, 2018: Brachytherapy
https://www.readbyqxmd.com/read/29772408/hysteroscopic-myomectomy-of-a-large-submucosal-leiomyoma-with-novel-use-of-fluid-warming
#11
Tess Chase, Stephanie J Estes
Uterine fibroid size is often considered a limiting factor for considering the surgical approach to myomectomy. In this case, a 35-year-old woman presented with heavy menstrual bleeding and desire for fertility. An ultrasound three months prior could not assess the endometrium and suggested leiomyoma. Magnetic resonance imaging of the pelvis identified a fundal submucosal myoma measuring 6.8 × 7.1 × 3.5 cm. A planned staged hysteroscopic resection of the large submucosal fibroid with intramural component was achieved...
May 14, 2018: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/29770767/pelvic-abscess-drainage-outcome-with-factors-affecting-the-clinical-success
#12
Devrim Akıncı, Onur Ergun, Çağdaş Topel, Türkmen Çiftçi, Okan Akhan
PURPOSE: We aimed to evaluate the success and complication rates of image-guided pelvic abscess drainage with emphasis on factors affecting the clinical success. METHODS: During a 7-year period, 185 pelvic abscesses were treated in 163 patients under ultrasonography and fluoroscopy (n=140) or computed tomography (n=45) guidance with transabdominal (n=107), transvaginal (n=39), transrectal (n=21) and transgluteal (n=18) approaches. Abscess characteristics (etiology, number, size, intrastructure, microbiological content, presence of fistula), patient demographics (age, sex, presence of malignancy, primary disease, antibiotic treatments), procedure-related factors (guidance method, access route, catheter size) and their effects on clinical success, complications, and duration of catheterization were statistically analyzed...
May 2018: Diagnostic and Interventional Radiology: Official Journal of the Turkish Society of Radiology
https://www.readbyqxmd.com/read/29769600/x-ray-based-virtual-histology-allows-guided-sectioning-of-heavy-ion-stained-murine-lungs-for-histological-analysis
#13
Jonas Albers, M Andrea Markus, Frauke Alves, Christian Dullin
Examination of histological or immunohistochemically stained 2D sections of embedded tissue is one of the most frequently used tools in biomedical research and clinical routine. Since to date, targeted sectioning of specific regions of interest (ROI) in the sample is not possible, we aimed at developing a guided sectioning approach based on x-ray 3D virtual histology for heavy ion stained murine lung samples. For this purpose, we increased the contrast to noise ratio of a standard benchtop microCT by 5-10-fold using free-propagation phase contrast imaging and thus substantially improved image quality...
May 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29768067/the-development-of-fluorescence-guided-surgery-for-pancreatic-cancer-from-bench-to-clinic
#14
Thinzar M Lwin, Robert M Hoffman, Michael Bouvet
Surgeons face major challenges in achieving curative R0 resection for pancreatic cancers. When the lesion is localized, they must appropriately visualize the tumor, determine appropriate resection margins, and ensure complete tumor clearance. Real-time surgical navigation using fluorescence-guidance has enhanced the ability of surgeons to see the tumor and has the potential to assist in achieving more oncologically-complete resections. When there is metastatic disease, fluorescence enhancement can help detect these lesions and prevent unnecessary and futile surgeries...
May 16, 2018: Expert Review of Anticancer Therapy
https://www.readbyqxmd.com/read/29766937/enhanced-resection-of-primary-high-grade-gliomas-using-a-combination-of-intraoperative-magnetic-resonance-imaging-and-intraoperative-fluorescence-5-aminolevulinic-acid-a-single-centre-experience
#15
Vikas Sharma, Rishabh Kedia, Karanjit S Narang, Ajaya N Jha
Background: The extent of resection (EOR) of a tumor is a proven prognostic factor in patients undergoing surgery for suspected high grade glioma. A few recent publications have shown the importance of intraoperative magnetic resonance imaging (iMRI) with 5-aminolevulinic acid (5-ALA) fluorescence-guidance in order to maximally increase the EOR. Aim: The objective of our study was to calculate the effect on survival of patients with high grade gliomas of resection using both iMRI and 5-ALA fluorescence-guidance as intraoperative adjuncts...
May 2018: Neurology India
https://www.readbyqxmd.com/read/29765388/changes-of-vegetation-distribution-in-the-east-dongting-lake-after-the-operation-of-the-three-gorges-dam-china
#16
Jia-Yu Hu, Yong-Hong Xie, Yue Tang, Feng Li, Ye-Ai Zou
Water regime is regarded as the primary factor influencing the vegetation distribution in natural wetland ecosystems. However, the effect of water regime change induced by large-scale hydraulic engineering on vegetation distribution is still unclear. In this study, multi-temporal TM/ETM+/OLI images and hydrological data from 1995 to 2015 were used to elucidate how the change in water regime influenced the vegetation distribution in the East Dongting Lake (EDTL), especially after the operation of the Three Gorges Dam (TGD) in 2003...
2018: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29763612/topographic-correspondence-of-macular-atrophy-with-choroidal-neovascularization-in-ranibizumab-treated-eyes-of-the-trex-amd-trial
#17
Nizar Saleh Abdelfattah, Amirhossein Hariri, Mayss Al-Sheikh, Sean Pitetta, Adel Ebraheem, Charles C Wykoff, SriniVas R Sadda
PURPOSE: To quantify the extent of topographic correspondence between baseline (BSL) CNV and macular atrophy (MA) at follow-up in eyes with NVAMD. DESIGN: Post hoc analysis of randomized, controlled clinical trial data. METHODS: Sixty treatment-naïve neovascular age-related macular degeneration (NVAMD) patients from TREX-AMD trial were followed for 18-months. Regions of month-18 macular atrophy (MA) were graded on fundus autofluorescence (FAF) with guidance of spectral domain optical coherence tomography (SD-OCT)...
May 12, 2018: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/29761663/a-prospective-pilot-study-on-early-toxicity-from-a-simultaneously-integrated-boost-technique-for-canine-sinonasal-tumours-using-image-guided-intensity-modulated-radiation-therapy
#18
A Soukup, V Meier, S Pot, K Voelter, C Rohrer Bley
In order to overcome the common local treatment failure of canine sinonasal tumours, integrated boost techniques were tried in the cobalt/orthovoltage era, but dismissed because of unacceptable early (acute) toxicity. Intriguingly, a recent calculation study of a simultaneously integrated boost (SIB) technique for sinonasal irradiation using intensity-modulated radiation therapy (IMRT) predicted theoretical feasibility. In this prospective pilot study we applied a commonly used protocol of 10 × 4.2 Gy to the planning target volume (PTV) with a 20%-SIB dose to the gross tumour volume (GTV)...
May 14, 2018: Veterinary and Comparative Oncology
https://www.readbyqxmd.com/read/29761001/multiscale-nonlinear-microscopy-and-widefield-white-light-imaging-enables-rapid-histological-imaging-of-surgical-specimen-margins
#19
Michael G Giacomelli, Tadayuki Yoshitake, Lucas C Cahill, Hilde Vardeh, Liza M Quintana, Beverly E Faulkner-Jones, Jeff Brooker, James L Connolly, James G Fujimoto
The ability to histologically assess surgical specimens in real-time is a long-standing challenge in cancer surgery, including applications such as breast conserving therapy (BCT). Up to 40% of women treated with BCT for breast cancer require a repeat surgery due to postoperative histological findings of close or positive surgical margins using conventional formalin fixed paraffin embedded histology. Imaging technologies such as nonlinear microscopy (NLM), combined with exogenous fluorophores can rapidly provide virtual H&E imaging of surgical specimens without requiring microtome sectioning, facilitating intraoperative assessment of margin status...
May 1, 2018: Biomedical Optics Express
https://www.readbyqxmd.com/read/29760987/5-ala-fluorescence-and-laser-doppler-flowmetry-for-guidance-in-a-stereotactic-brain-tumor-biopsy
#20
Neda Haj-Hosseini, Johan C O Richter, Peter Milos, Martin Hallbeck, Karin Wårdell
A fiber optic probe was developed for guidance during stereotactic brain biopsy procedures to target tumor tissue and reduce the risk of hemorrhage. The probe was connected to a setup for the measurement of 5-aminolevulinic acid (5-ALA) induced fluorescence and microvascular blood flow. Along three stereotactic trajectories, fluorescence (n = 109) and laser Doppler flowmetry (LDF) (n = 144) measurements were done in millimeter increments. The recorded signals were compared to histopathology and radiology images...
May 1, 2018: Biomedical Optics Express
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