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https://www.readbyqxmd.com/read/28737989/incremental-effect-of-the-addition-of-prescriber-restrictions-on-a-state-medicaid-s-pharmacy-only-patient-review-and-restriction-program
#1
Shellie L Keast, Timothy Pham, Ashley Teel, Nancy J Nesser
BACKGROUND: Patient review and restriction programs (PRRPs), used by state Medicaid programs to limit potential abuse and misuse of opioids and related controlled medications, often restrict members to a single pharmacy for controlled medications. While most states use a restricted pharmacy access model, not all states include restricted prescriber access. Oklahoma Medicaid (MOK) added a restricted prescriber access feature to its PRRP in July 2014. OBJECTIVE: To evaluate the incremental effect that the addition of a prescriber restriction to MOK's pharmacy-only PRRP had on the pharmacy and resource utilization of the enrolled members...
August 2017: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/28736840/issop-position-statement-on-migrant-child-health
#2
REVIEW
(no author information available yet)
Greater numbers of children are on the move than ever before. In 2015, the number of forcibly displaced people across the globe reached 65.3 million. Of the more than 1 million migrants, asylum seekers, and refugees who arrived in Europe in 2015, nearly one third were children, and 90,000 of these children were unaccompanied. Child migrants are among the most vulnerable, even after arriving at their destination. The health of migrant children is related to their health status before their journey, the conditions during their journey and at their destination, and the physical and mental health of their caregivers...
July 23, 2017: Child: Care, Health and Development
https://www.readbyqxmd.com/read/28735039/frequency-and-correlates-of-sleep-disturbance-in-methadone-and-buprenorphine-maintained-patients
#3
Kelly E Dunn, Patrick H Finan, D Andrew Tompkins, Eric C Strain
BACKGROUND: Opioid use disorder (OUD) is a significant public health problem, and opioid maintenance treatment (OMT) on methadone or buprenorphine is a common approach. This study characterized sleep impairment in patients maintained on methadone or buprenorphine, and evaluated its association with psychiatric and medical comorbidities. METHODS: Participants (N=185) maintained on methadone (N=125) or buprenorphine (N=60) for OUD completed the Medical Outcomes Study Sleep Scale (MOS) to provide a point-prevalence assessment of sleep impairment...
July 14, 2017: Addictive Behaviors
https://www.readbyqxmd.com/read/28732836/adherence-and-healthcare-utilization-among-older-adults-with-copd-and-depression
#4
Jennifer S Albrecht, Bilal Khokhar, Ting-Ying Huang, Yu-Jung Wei, Ilene Harris, Patience Moyo, Peter Hur, Susan W Lehmann, Giora Netzer, Linda Simoni-Wastila
BACKGROUND AND OBJECTIVE: Adherence to chronic obstructive pulmonary disease (COPD) maintenance medications and antidepressants may reduce healthcare utilization among multimorbid individuals with COPD and depression. We quantified the independent effects of adherence to antidepressants and COPD maintenance medications on healthcare utilization among individuals co-diagnosed with COPD and depression. PROCEDURES: We conducted a retrospective cohort study using a 2006-2012 5% random sample of Medicare beneficiaries co-diagnosed with COPD and depression who had two or more prescription fills of both COPD maintenance medications and antidepressants...
August 2017: Respiratory Medicine
https://www.readbyqxmd.com/read/28732479/an-integrated-computational-experimental-approach-reveals-yersinia-pestis-genes-essential-across-a-narrow-or-a-broad-range-of-environmental-conditions
#5
Nicola J Senior, Kalesh Sasidharan, Richard J Saint, Andrew E Scott, Mitali Sarkar-Tyson, Philip M Ireland, Helen L Bullifent, Z Rong Yang, Karen Moore, Petra C F Oyston, Timothy P Atkins, Helen S Atkins, Orkun S Soyer, Richard W Titball
BACKGROUND: The World Health Organization has categorized plague as a re-emerging disease and the potential for Yersinia pestis to also be used as a bioweapon makes the identification of new drug targets against this pathogen a priority. Environmental temperature is a key signal which regulates virulence of the bacterium. The bacterium normally grows outside the human host at 28 °C. Therefore, understanding the mechanisms that the bacterium used to adapt to a mammalian host at 37 °C is central to the development of vaccines or drugs for the prevention or treatment of human disease...
July 21, 2017: BMC Microbiology
https://www.readbyqxmd.com/read/28732367/significantly-more-intense-pain-in-methadone-maintained-patients-who-are-addicted-to-nicotine
#6
Lian-Zhong Liu, Lin-Xiang Tan, Yan-Min Xu, Xue-Bing Liu, Wen-Cai Chen, Jun-Hong Zhu, Jin Lu, Bao-Liang Zhong
Pain and cigarette smoking are very common in heroin-dependent patients (HDPs) receiving methadone maintenance treatment (MMT) and both have substantial negative effects on HDPs' physical and mental health. Nevertheless, very few studies have assessed the relationship between the two in HDPs. This study examined the association between pain intensity and smoking in Chinese methadone-maintained HDPs. A total of 603 HDPs were consecutively recruited from three MMT clinics in Wuhan, China, and administered with a socio-demographic and drug use questionnaire, a smoking questionnaire concerning average number of cigarettes smoked daily and Heaviness of Smoking Index, and Zung's Self-rating Depression Scale...
July 13, 2017: Oncotarget
https://www.readbyqxmd.com/read/28731034/regulation-of-hepatic-glucose-metabolism-in-health-and-disease
#7
REVIEW
Max C Petersen, Daniel F Vatner, Gerald I Shulman
The liver is crucial for the maintenance of normal glucose homeostasis - it produces glucose during fasting and stores glucose postprandially. However, these hepatic processes are dysregulated in type 1 and type 2 diabetes mellitus, and this imbalance contributes to hyperglycaemia in the fasted and postprandial states. Net hepatic glucose production is the summation of glucose fluxes from gluconeogenesis, glycogenolysis, glycogen synthesis, glycolysis and other pathways. In this Review, we discuss the in vivo regulation of these hepatic glucose fluxes...
July 21, 2017: Nature Reviews. Endocrinology
https://www.readbyqxmd.com/read/28729383/definitions-and-end-points-for-interventional-studies-for-arteriovenous-dialysis-access
#8
Gerald A Beathard, Charmaine E Lok, Marc H Glickman, Ahmed A Al-Jaishi, Donna Bednarski, David L Cull, Jeffery H Lawson, Timmy C Lee, Vandana D Niyyar, Donna Syracuse, Scott O Trerotola, Prabir Roy-Chaudhury, Surendra Shenoy, Margo Underwood, Haimanot Wasse, Karen Woo, Theodore H Yuo, Thomas S Huber
This paper is part of the Clinical Trial Endpoints for Dialysis Vascular Access Project of the American Society of Nephrology Kidney Health Initiative. The purpose of this project is to promote research in vascular access by clarifying trial end points which would be best suited to inform decisions in those situations in which supportive clinical data are required. The focus of a portion of the project is directed toward arteriovenous access. There is a potential for interventional studies to be directed toward any of the events that may be associated with an arteriovenous access' evolution throughout its life cycle, which has been divided into five distinct phases...
July 20, 2017: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/28727956/increasing-availability-of-benzodiazepines-among-people-who-inject-drugs-in-a-canadian-setting
#9
Geoffrey Walton, Huiru Dong, M J Milloy, Kora DeBeck, Thomas Kerr, Evan Wood, Kanna Hayashi
BACKGROUND: Benzodiazepine misuse is associated with mortality and is common among people who inject drugs (PWID). This study aimed to examine the temporal trends in the availability of benzodiazepines among PWID in a Canadian setting, and to identify factors associated with more immediate access to benzodiazepines. METHODS: Data were derived from three prospective cohorts of PWID in Vancouver, Canada, between June 2012 and May 2015. The primary outcome was the perceived availability of benzodiazepines, measured in three levels: not available, delayed availability (available in ≥10 min), and immediate availability (available in <10 min)...
July 20, 2017: Substance Abuse
https://www.readbyqxmd.com/read/28727546/a-formative-evaluation-of-a-diabetes-prevention-program-using-the-re-aim-framework-in-a-learning-health-care-system-utah-2013-2015
#10
Kimberly D Brunisholz, Jaewhan Kim, Lucy A Savitz, Mia Hashibe, Lisa H Gren, Sharon Hamilton, Kelly Huynh, Elizabeth A Joy
INTRODUCTION: Evaluation of interventions can help to close the gap between research and practice but seldom takes place during implementation. Using the RE-AIM framework, we conducted a formative evaluation of the first year of the Intermountain Healthcare Diabetes Prevention Program (DPP). METHODS: Adult patients who met the criteria for prediabetes (HbA1c of 5.70%-6.49% or fasting plasma glucose of 100-125 mg/dL) were attributed to a primary care provider from August 1, 2013, through July 31, 2014...
July 20, 2017: Preventing Chronic Disease
https://www.readbyqxmd.com/read/28727346/-doctor-physical-activity-at-my-age
#11
Martial Coutaz
Engaging in regular and appropriate physical activity confers health benefits at any age. For seniors, swapping the role of « sedentary » for « someone who's on the move » offers much more substantial benefits than any medication, and notably even starting at a dose of 10-15 minutes per day ! Any physician who cares for elderly patients must pursue the objective of encouraging physical activity that is integrated into daily life (e.g. walking, gardening, shopping). This article consists of a literature review concerning the evidence for the benefits of physical activity in seniors in terms of quality of life, longevity, maintenance of functional independence, and prevention of cognitive decline...
April 19, 2017: Revue Médicale Suisse
https://www.readbyqxmd.com/read/28727179/overexpression-of-g%C3%AE-s-in-murine-osteoblasts-in-vivo-leads-to-increased-bone-mass-and-decreased-bone-quality
#12
Lucia Zhang, Kim S Sugamori, Colin Claridge, Ariana Dela Cruz, Marc D Grynpas, Jane Mitchell
GαS is a heterotrimeric G protein that transduces signals from activated G protein-coupled receptors on the cell surface to stimulate adenylyl cyclase/cyclic AMP signaling. GαS plays a central role in mediating numerous growth and maintenance processes including osteogenesis and bone turnover. Decreased GαS expression or activating mutations in GαS both affect bone suggesting that modulating GαS protein levels may be important for bone health and development. To examine the effects of increased osteoblastic GαS expression on bone development in vivo, we generated transgenic mice with GαS over-expression in osteoblasts (HOM-Gs mice) driven by the 3...
July 20, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/28727052/rapid-communication-subclinical-bovine-respiratory-disease-loci-and-pathogens-associated-with-lung-lesions-in-feedlot-cattle
#13
J N Kiser, T E Lawrence, M Neupane, C M Seabury, J F Taylor, J E Womack, H L Neibergs
Bovine respiratory disease (BRD) is an economically important disease of feedlot cattle that is caused by viral and bacterial pathogen members of the BRD complex. Many cases of subclinical BRD go untreated and are not detected until slaughter, when lung lesions are identified. The objectives of this study were to identify which BRD pathogens were associated with the presence of lung lesions at harvest and to identify genomic loci that were associated with susceptibility to lung lesions as defined by consolidation of the lung and/or the presence of fibrin tissue...
June 2017: Journal of Animal Science
https://www.readbyqxmd.com/read/28727021/physiology-and-endocrinology-symposium-the-effects-of-poor-maternal-nutrition-during-gestation-on-offspring-postnatal-growth-and-metabolism
#14
M L Hoffman, S A Reed, S M Pillai, A K Jones, K K McFadden, S A Zinn, K E Govoni
Poor maternal nutrition during gestation has been linked to poor growth and development, metabolic dysfunction, impaired health, and reduced productivity of offspring in many species. Poor maternal nutrition can be defined as an excess or restriction of overall nutrients or specific macro- or micronutrients in the diet of the mother during gestation. Interestingly, there are several reports that both restricted- and over-feeding during gestation negatively affect offspring postnatal growth with reduced muscle and bone deposition, increased adipose accumulation, and metabolic dysregulation through reduced leptin and insulin sensitivity...
May 2017: Journal of Animal Science
https://www.readbyqxmd.com/read/28725328/heterozygous-familial-hypercholesterolemia-with-apoe-haplotype-a-prospective-harbinger-of-a-catastrophic-cardiovascular-event
#15
Glenmore Lasam, Siddesh Shambhu, Robert Fishberg
We report a very young man with heterozygous familial hypercholesterolemia (FH) with APOE haplotype and a significant cardiac family history who underwent cardiac catheterization for intermittent episodes of exertional dyspnea and was noted to have a severe triple vessel coronary artery disease (CAD). He underwent coronary artery bypass graft (CABG) surgery which was uneventful. He was discharged on antiplatelet, beta blocker, nitrate, and statin. On routine health maintenance evaluation, he had no cardiac complaints and had been tolerating well his activities of daily living...
June 2017: Cardiology Research
https://www.readbyqxmd.com/read/28724370/facing-unemployment-study-protocol-for-the-implementation-and-evaluation-of-a-community-based-intervention-for-psychological-well-being-promotion
#16
Ana Virgolino, Maria João Heitor, Joana Carreiras, Elisa Lopes, Simon Øverland, Steffen Torp, Dora Guðmundsdóttir, José Pereira Miguel, M Fátima Reis, Osvaldo Santos
BACKGROUND: Economic crises and unemployment have profound impact on mental health and well-being. Main goal of the Healthy Employment (HE) project is to enhance intersectoral actions promoting mental health among unemployed, namely through the implementation and effectiveness-evaluation of short-term and sustainable group interventions. METHODS: The project follows a RE-AIM-based (Reach, Effectiveness, Adoption, Implementation and Maintenance) framework for assessing a cognitive-behavioural and psychoeducational intervention that has been developed for promoting mental health among unemployed people...
July 19, 2017: BMC Psychiatry
https://www.readbyqxmd.com/read/28723981/intestinal-microbiota-in-digestive-diseases
#17
Maria do Carmo Friche Passos, Joaquim Prado Moraes-Filho
BACKGROUND: In recent years, especially after the development of sophisticated metagenomic studies, research on the intestinal microbiota has increased, radically transforming our knowledge about the microbiome and its association with health maintenance and disease development in humans. Increasing evidence has shown that a permanent alteration in microbiota composition or function (dysbiosis) can alter immune responses, metabolism, intestinal permeability, and digestive motility, thereby promoting a proinflammatory state...
July 6, 2017: Arquivos de Gastroenterologia
https://www.readbyqxmd.com/read/28722213/countering-resistance-to-protected-area-extension
#18
David Lindenmayer, Simon Thorn, Reed Noss
The establishment of protected areas is a critical strategy for conserving biodiversity. Key policy directives like the Aichi targets seek to expand protected areas to 17% of the earth's land surface, with calls by some conservation biologists for much more. However, in places such as the USA, Germany and Australia, attempts to increase protected areas are meeting strong resistance from communities, industry groups, and governments. Here we provide case studies of such resistance and suggest four ways to tackle this problem: (1) Broaden the case for protected areas beyond just nature conservation, to include the economic, human health, and other benefits, and translate these into a persuasive business case for protected areas...
July 19, 2017: Conservation Biology: the Journal of the Society for Conservation Biology
https://www.readbyqxmd.com/read/28721154/obesity-and-inflammation-the-linking-mechanism-and-the-complications
#19
Mohammed S Ellulu, Ismail Patimah, Huzwah Khaza'ai, Asmah Rahmat, Yehia Abed
Obesity is the accumulation of abnormal or excessive fat that may interfere with the maintenance of an optimal state of health. The excess of macronutrients in the adipose tissues stimulates them to release inflammatory mediators such as tumor necrosis factor α and interleukin 6, and reduces production of adiponectin, predisposing to a pro-inflammatory state and oxidative stress. The increased level of interleukin 6 stimulates the liver to synthesize and secrete C-reactive protein. As a risk factor, inflammation is an imbedded mechanism of developed cardiovascular diseases including coagulation, atherosclerosis, metabolic syndrome, insulin resistance, and diabetes mellitus...
June 2017: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/28721128/insulin-and-brain-aging
#20
REVIEW
Agnieszka Baranowska-Bik, Wojciech Bik
The world's population is living much longer than in the past. It is crucial to find as many pathological factors that deteriorate the health condition and well-being of elderly people as possible. Loss of activity and functions over time is typical for elderly people. Aging affects brain function, metabolism and structure in different ways, and these effects have multiple etiologies. Cognitive impairment, impaired neurotransmitter activity and reduction of brain volume are observed in the elderly population...
June 2017: Przeglad Menopauzalny, Menopause Review
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