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GTN Patches

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https://www.readbyqxmd.com/read/27873224/therapeutic-potential-of-transdermal-glyceryl-trinitrate-in-the-management-of-acute-stroke
#1
Jason P Appleton, Nikola Sprigg, Philip M Bath
The nitric oxide donor, glyceryl trinitrate (GTN), is a candidate treatment for the management of acute stroke with haemodynamic and potential reperfusion and neuroprotective effects. When administered as a transdermal patch during the acute and subacute phases after stroke, GTN was safe, lowered blood pressure, maintained cerebral blood flow, and did not induce cerebral steal or alter functional outcome. However, when given within 6 h of stroke onset, GTN reduced death and dependency (odds ratio 0.52; 95% confidence interval 0...
November 21, 2016: CNS Drugs
https://www.readbyqxmd.com/read/27470183/randomized-clinical-trial-of-the-use-of-glyceryl-trinitrate-patches-to-aid-arteriovenous-fistula-maturation
#2
M Field, D McGrogan, Y Marie, M Joinson, C Andujar, M Dutton, H Krishnan, J Hodson, D van Dellen, N G Inston
BACKGROUND: Arteriovenous fistulas are critical for haemodialysis, but maturation rates remain poor. Experimental and anecdotal evidence has supported the use of transdermal glyceryl trinitrate (GTN) patches. The aim of this RCT was to determine whether use of a GTN patch aids arteriovenous fistula maturation. METHODS: Patients referred for arteriovenous fistula formation were eligible. The GTN or placebo patch was applied immediately after surgery and left in situ for 24 h...
September 2016: British Journal of Surgery
https://www.readbyqxmd.com/read/26279411/comparison-between-transdermal-nitroglycerin-and-sildenafil-citrate-in-intrauterine-growth-restriction-effects-on-uterine-umbilical-and-fetal-middle-cerebral-artery-pulsatility-indices
#3
A Trapani, L F Gonçalves, T F Trapani, M J Franco, R N Galluzzo, M M S Pires
OBJECTIVES: To evaluate the effects of transdermal nitroglycerin (GTN) and sildenafil citrate on Doppler velocity waveforms of the uterine (UtA), umbilical (UA) and fetal middle cerebral (MCA) arteries in pregnancies with intrauterine growth restriction (IUGR). METHODS: This was a prospective study of 35 singleton pregnancies (gestational age, 24-31 weeks) with IUGR and abnormal UtA and UA Doppler waveforms. We compared maternal arterial blood pressure and Z-scores of the pulsatility index (PI) of UtA, UA and fetal MCA before and after application of a transdermal GTN patch (average dose, 0...
July 2016: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/26102687/8c-09-a-central-iliac-arteriovenous-anastomosis-results-in-durable-and-substantial-blood-pressure-reduction-in-a-woman-with-uncontrolled-hypertension-and-multiple-drug-intolerances
#4
M Saxena, D Collier, A Jain, C Knight, A Mathur, P Sobotka, M Lobo
OBJECTIVE: Intolerance of antihypertensive medications is a major cause of non-adherence to pharmacotherapy leading to poor blood pressure control in the hypertensive population. We investigated the role of a central iliac arteriovenous (AV) anastomosis in a woman with uncontrolled hypertension due to multidrug intolerances. DESIGN AND METHOD: A sixty-one year old Caucasian female with long-standing poorly-controlled hypertension was referred with multiple drug intolerances...
June 2015: Journal of Hypertension
https://www.readbyqxmd.com/read/25583629/pharmacological-interventions-for-the-treatment-of-achilles-tendinopathy-a-systematic-review-of-randomized-controlled-trials
#5
Nicola Maffulli, Rocco Papalia, Stefano D'Adamio, Lorenzo Diaz Balzani, Vincenzo Denaro
INTRODUCTION: Several pharmacological interventions have been proposed for the management of Achilles tendinopathy, with no agreement on which is the overall best option available. This systematic review investigates the efficacy and safety of different local pharmacological treatments for Achilles tendinopathy. SOURCES OF DATA: We included only randomized controlled studies (RCTs) focusing on clinical and functional outcomes of therapies consisting in injection of a substance or local application...
March 2015: British Medical Bulletin
https://www.readbyqxmd.com/read/25364398/nitric-oxide-signaling-pathway-activation-inhibits-the-immune-escape-of-pancreatic-carcinoma-cells
#6
Yebin Lu, Juanjuan Hu, Weijia Sun, Xiaohui Duan, Xiong Chen
The aim of the present study was to investigate the effect of the nitric oxide signaling pathway on immune escape; thus, a tumorigenesis model was established using nude mice. The mice were inoculated with pancreatic carcinoma cells and divided into two groups, a glyceryl trinitrate (GTN) and a placebo group. When tumor volumes reached 150 mm(3), the mice in the GTN group were treated with GTN transdermal patches (dose, 7.3 μg/h) while the mice in the placebo group were administered untreated patches. Following treatment, the tumor volume was recorded every 3-4 days and after 28 days, the tumors were analyzed...
December 2014: Oncology Letters
https://www.readbyqxmd.com/read/24918079/the-effects-of-glyceryl-trinitrate-patch-on-the-treatment-of-preterm-labor-a-single-blind-randomized-clinical-trial
#7
Anisodowleh Nankali, Parnian Kord Jamshidi, Mansour Rezaei
BACKGROUND: Preterm labor (PTL) is one of the main causes of neonatal mortality and morbidity. PTL leads to serious complications especially in the gestational age prior to 24-26 weeks. The aim of this study was to investigate the effect of glyceryl trinitrate (GTN) patch on the treatment and complications of PTL. METHODS: In this clinical trial, 84 singleton pregnant women with gestational age of 27-35 weeks were surveyed. PTL was clinically diagnosed and the patients were randomly divided into two groups who were treated with GTN or placebo for 48 hr...
April 2014: Journal of Reproduction & Infertility
https://www.readbyqxmd.com/read/24901312/calcium-channel-blockers-for-inhibiting-preterm-labour-and-birth
#8
REVIEW
Vicki Flenady, Aleena M Wojcieszek, Dimitri N M Papatsonis, Owen M Stock, Linda Murray, Luke A Jardine, Bruno Carbonne
BACKGROUND: Preterm birth is a major contributor to perinatal mortality and morbidity, affecting around 9% of births in high-income countries and an estimated 13% of births in low- and middle-income countries. Tocolytics are drugs used to suppress uterine contractions for women in preterm labour. The most widely used tocolytic are the betamimetics, however, these are associated with a high frequency of unpleasant and sometimes severe maternal side effects. Calcium channel blockers (CCBs) (such as nifedipine) may have similar tocolytic efficacy with less side effects than betamimetics...
2014: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/24747626/management-of-tennis-elbow-with-topical-glyceryl-trinitrate
#9
RANDOMIZED CONTROLLED TRIAL
Raif Ozden, Vedat Uruç, Yunus Doğramaci, Aydiner Kalaci, Erhan Yengil
OBJECTIVE: The aim of this study was to evaluate the treatment results of the application of nitric oxide (NO) in the form of topical glyceryl trinitrate (GTN) for the treatment of lateral epicondylitis (LE). METHODS: The study included 40 patients with LE randomized into 2 equal groups. Selection criteria included the presence of pain, tenderness, and positive pain stimulating maneuvers. Glyceryl trinitrate patches were applied to the area of maximal tenderness once a day in the treatment group and placebo patches in the control group...
2014: Acta Orthopaedica et Traumatologica Turcica
https://www.readbyqxmd.com/read/23599320/impact-of-autologous-blood-injections-in-treatment-of-mid-portion-achilles-tendinopathy-double-blind-randomised-controlled-trial
#10
RANDOMIZED CONTROLLED TRIAL
Kevin J Bell, Mark L Fulcher, David S Rowlands, Ngaire Kerse
OBJECTIVE: To assess the effectiveness of two peritendinous autologous blood injections in addition to a standardised eccentric calf strengthening programme in improving pain and function in patients with mid-portion Achilles tendinopathy. DESIGN: Single centre, participant and single assessor blinded, parallel group, randomised, controlled trial. SETTING: Single sports medicine clinic in New Zealand. PARTICIPANTS: 53 adults (mean age 49, 53% men) with symptoms of unilateral mid-portion Achilles tendinopathy for at least three months...
2013: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/23230283/acute-and-chronic-effects-of-glyceryl-trinitrate-therapy-on-insulin-and-glucose-regulation-in-humans
#11
Sean Jedrzkiewicz, John D Parker
This study examined the effect of acute and sustained transdermal glyceryl trinitrate (GTN) therapy on insulin and glucose regulation. Totally, 12 males (18-30 years) underwent a glucose tolerance test at baseline (visit 1), 90 minutes after acute transdermal GTN 0.6 mg/h (visit 2), following 7 days of continuous GTN (visit 3), and 2 to 3 days after stopping GTN (visit 4). At each visit, plasma glucose and insulin concentrations were measured before and 30, 60, 90, and 120 minutes after a 75-g oral glucose load...
May 2013: Journal of Cardiovascular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/22930695/topical-glyceryl-trinitrate-treatment-of-chronic-patellar-tendinopathy-a-randomised-double-blind-placebo-controlled-clinical-trial
#12
RANDOMIZED CONTROLLED TRIAL
Mirjam Steunebrink, Johannes Zwerver, Ruben Brandsema, Petra Groenenboom, Inge van den Akker-Scheek, Adam Weir
OBJECTIVES: To assess if continuous topical glyceryl trinitrate (GTN) treatment improves outcome in patients with chronic patellar tendinopathy when compared with eccentric training alone. METHODS: Randomised double-blind, placebo-controlled clinical trial comparing a 12-week programme of using a GTN or placebo patch in combination with eccentric squats on a decline board. Measurements were performed at baseline, 6, 12 and 24 weeks. Primary outcome measure was the Victorian Institute of Sports Assessment-Patella (VISA-P) questionnaire...
January 2013: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/22352102/efficacy-of-transdermal-nitroglycerine-in-idiopathic-pre-term-labour
#13
Shahida Shaikh, Abdul Hameed Shaikh, Saleem Akhter, Basma Isran
OBJECTIVE: To determine the efficacy of transdermal Nitroglycerine patch in idiopathic pre-term labour and foetomaternal outcome. METHODS: This quasi-experimental study was conducted at the Obstetrics Unit-II of Shaikh Zayed Hospital for Women, Chandka Medical College, Shaheed Mohtarma Benazir Bhutto Medical University, Larkana, from Jan 1 to June 30, 2010. Sixtyfive pregnant women at 28-34 weeks of gestation were recruited after they met the selection criteria based on non-probability consecutive sampling...
January 2012: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/22274747/nitroglycerin-prevents-coagulopathies-and-foetal-death-associated-with-abnormal-maternal-inflammation-in-rats
#14
Tiziana Cotechini, Maha Othman, Charles H Graham
Inflammation-associated foetal loss is often linked to maternal coagulopathies. Here, we characterised the role of maternal inflammation in the development of various systemic maternal coagulopathies and foetal death during mid-to-late gestation in rats. Since nitric oxide (NO) functions as an inhibitor of platelet aggregation and anti-oxidant, we also tested whether the NO mimetic nitroglycerin (glyceryl trinitrate, GTN) prevents inflammation-associated coagulopathies and foetal death. To induce chronic inflammation, pregnant Wistar rats were injected with low-doses of lipopolysaccharide (LPS; 10-40 μg/kg) on gestational days (GD) 13...
May 2012: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/22244067/the-role-of-nitric-oxide-in-tendon-healing
#15
REVIEW
Ali R Bokhari, George A C Murrell
Nitric oxide (NO) is a small free radical that is generated by a family of enzymes called the nitric oxide synthases (NOS). There are 3 isoforms of NOS: endothelial NOS (eNOS), brain or neuronal NOS (bNOS), and inducible NOS (iNOS). In experiments performed during the last 20 years, we have shown that NO is induced by all 3 isoforms of NOS after tendon injury and that NOS activity is upregulated in tendinopathy. In normal uninjured tendons, there is very little NOS activity. In injured rat and human tendons, NOS activity was found in healing fibroblasts in a temporal fashion...
February 2012: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/21609410/the-effect-of-transdermal-glyceryl-trinitrate-on-24-h-ambulatory-blood-pressure-in-acute-subacute-stroke
#16
RANDOMIZED CONTROLLED TRIAL
Chamila M Geeganage, Andrew J G Bath, Philip M W Bath
BACKGROUND: High blood pressure is a common complication in acute stroke and is associated with a poor outcome. Aims This study assesses the effects of transdermal glyceryl trinitrate on 24 h ambulatory blood pressure in patients with recent stroke. METHODS: One hundred and seven patients with acute ischaemic or haemorrhagic stroke were included. The patients had been enrolled in one of two trials of transdermal glyceryl trinitrate (5 mg daily) or placebo/control, and underwent 24 h ambulatory blood pressure monitoring (56 glyceryl trinitrate, 51 control)...
August 2011: International Journal of Stroke: Official Journal of the International Stroke Society
https://www.readbyqxmd.com/read/21296600/cost-effectiveness-of-transdermal-nitroglycerin-use-for-preterm-labor
#17
RANDOMIZED CONTROLLED TRIAL
Yanfang Guo, Christopher J Longo, Rihua Xie, Shi Wu Wen, Mark C Walker, Graeme N Smith
OBJECTIVE: The objective of this study was to determine the cost-effectiveness of using transdermal nitroglycerin (GTN) for cases of preterm labor. METHODS: The study included 153 women with clinical preterm labor, who were randomly allocated to either a GTN or placebo arm. All randomized cases were included in the final economic analysis. Differences between the two arms in gestational age at delivery, neonatal intensive care unit (NICU) admission, length of NICU stay, and NICU cost were assessed...
March 2011: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/20717044/a-randomized-controlled-trial-of-valdecoxib-and-glyceryl-trinitrate-for-the-prevention-of-post-ercp-pancreatitis
#18
RANDOMIZED CONTROLLED TRIAL
Vikram Bhatia, Vineet Ahuja, Subrat Kumar Acharya, Pramod Kumar Garg
BACKGROUND: Efforts to prevent post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis have been largely unsuccessful. Cyclo-oxygenase-2 enzyme-mediated inflammatory pathway has been suggested in the pathophysiology of acute pancreatitis. Glyceryl trinitrate (GTN) might prevent post-ERCP pancreatitis by relaxing the sphincter of Oddi. OBJECTIVE: To evaluate the efficacy of valdecoxib, a cyclo-oxygenase-2 inhibitor, and GTN transdermal patch for the prevention of post-ERCP pancreatitis...
February 2011: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/20557963/nitrates-for-stable-angina-a-systematic-review-and-meta-analysis-of-randomized-clinical-trials
#19
REVIEW
Jiafu Wei, Taixiang Wu, Qing Yang, Mao Chen, Juan Ni, Dejia Huang
OBJECTIVE: To assess the effect (harms and benefits) of nitrates for stable angina. METHODS: We searched the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE and EMBASE. Randomized controlled trials with both parallel and crossover design were included. The following outcome measures were evaluated: number of angina attacks weekly and nitroglycerin consumption, quality of life, total exercise duration, time to onset of angina and time to 1 mm ST depression...
January 7, 2011: International Journal of Cardiology
https://www.readbyqxmd.com/read/20079349/sildenafil-and-glyceryl-trinitrate-reduce-tactile-allodynia-in-streptozotocin-injected-rats
#20
Claudia I Araiza-Saldaña, Héctor I Rocha-González, Mónica Ambriz-Tututi, Gabriela Castañeda-Corral, Nadia L Caram-Salas, Enrique Hong, Vinicio Granados-Soto
The possible antiallodynic effect of phosphodiesterase 5 inhibitor sildenafil and nitric oxide donor glyceryl trinitrate as well as the changes in phosphodiesterase 5A2 mRNA expression in dorsal root ganglion and spinal cord of allodynic diabetic rats was assessed. Diabetes was induced by streptozotocin (50mg/kg, i.p.) in male Wistar rats. Streptozotocin injection produced hyperlglycemia, polydipsia, polyphagia and polyuria as well as long-term tactile allodynia (12 weeks) and a reduction of phosphodiesterase 5A2 mRNA expression in spinal cord of diabetic rats...
April 10, 2010: European Journal of Pharmacology
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