Read by QxMD icon Read

Dua ocular

A M Yeung, L A Faraj, O D McIntosh, V K Dhillon, H S Dua
PurposeFibrin glue has been used successfully in numerous ophthalmic surgical procedures. Recently, fibrin glue has been used in limbal stem cell transplantation to reduce both operative time and to negate the need for sutures. The aim of this study was to determine the effects of fibrin glue on epithelial cell migration in vitro.MethodsCorneoscleral rims were split to retain the epithelial layer, Bowman's layer, and anterior stroma. Rims were cut into eight equal-sized pieces and were placed directly on culture plates or affixed with fibrin glue...
July 1, 2016: Eye
Namrata Sharma, Divya Singh, Prafulla K Maharana, Alka Kriplani, Thirumurthy Velpandian, Ravindra Mohan Pandey, Rasik B Vajpayee
PURPOSE: To compare the efficacy of topical umbilical cord serum drops (UCS) and amniotic membrane transplantation (AMT) in acute ocular chemical burns. DESIGN: Randomized controlled trial. METHODS: setting: Tertiary care hospital. STUDY POPULATION: Forty-five eyes with acute chemical burns of grade III, IV, and V (Dua's classification) presenting within the first week of injury were randomized into 3 groups (15 each)...
August 2016: American Journal of Ophthalmology
Henrike Westekemper, Francisco C Figueiredo, We Fong Siah, Nina Wagner, Klaus-Peter Steuhl, Daniel Meller
BACKGROUND: Amniotic membrane transplantation (AMT) has been used in the management of acute ocular chemical burns to promote epithelialisation, reduce inflammation and restore ocular surface integrity. The aim of this study is to analyse the morphological and functional outcomes of patients receiving AMT after ocular chemical burn. METHODS: We performed a retrospective analysis of all patients treated for acute ocular chemical burn between 1998 and 2008 in two participating centres (University of Duisburg-Essen, Germany and Royal Victoria Infirmary, Department of Ophthalmology, Newcastle University, UK)...
May 5, 2016: British Journal of Ophthalmology
Wendy Chao, Carlos Belmonte, José M Benitez Del Castillo, Anthony J Bron, Harminder S Dua, Kelly K Nichols, Gary D Novack, Stefan Schrader, Mark D Willcox, James S Wolffsohn, David A Sullivan
On March 21, 2015, a meeting was held in London, United Kingdom, to address the progress in targeting the unmet need for dry eye disease (DED) treatment. The meeting, which launched the i(2) = initiating innovation series, was sponsored by the Tear Film & Ocular Surface Society (TFOS; and supported by Dompé. The TFOS i(2) meeting was designed to review advances in the understanding of DED since publication of the 2007 TFOS International Dry Eye WorkShop (DEWS) report, and to help launch the highly anticipated sequel, DEWS II...
April 2016: Ocular Surface
Vikas Mittal, Rajat Jain, Ruchi Mittal, Urvish Vashist, Purvasha Narang
AIM: To study the outcomes of simple limbal epithelial transplantation (SLET) for unilateral total limbal stem cell deficiency (LSCD) secondary to severe ocular surface burns in children. METHODS: Retrospective interventional case series was performed at a private referral tertiary care centre. Children less than 15 years of age who underwent autologous SLET for total LSCD and had a minimum follow-up of 6 months were included in the study. Demographic and clinical data were recorded in a predesigned form...
August 2016: British Journal of Ophthalmology
J Mayouego Kouam, E Epée, S Azria, D Enyama, A Omgbwa Eballe, C Ebana Mvogo, M Cherifi
INTRODUCTION: Ocular and orbital trauma is a leading cause of acquired monocular blindness in childhood. These injuries differ from those in adults in some aspects of the management and prognosis, notably the risk of amblyopia. The goal of this study was to analyze the epidemiological, clinical and therapeutic features of ocular trauma in children who consulted in an eye emergency department in Île-de-France. PATIENTS AND METHODS: This was a descriptive, prospective and longitudinal study...
October 2015: Journal Français D'ophtalmologie
Ravi Sheshala, Yong Y Kok, Jun M Ng, Raghu R S Thakur, Kamal Dua
Ophthalmic drug delivery system is very interesting and challenging due to the normal physiologically factor of eyes which reduces the bioavailability of ocular products. The development of new ophthalmic dosage forms for existing drugs to improve efficacy and bioavailability, patient compliance and convenience has become one of the main trend in the pharmaceuticals industry. The present review encompasses various conventional and novel ocular drug delivery systems, methods of preparation, characterization and recent research in this area...
2015: Recent Patents on Drug Delivery & Formulation
Virinder K Dhillon, Mohamed S Elalfy, Mouhamed Al-Aqaba, Ankur Gupta, Surajit Basu, Harminder S Dua
PURPOSE: To evaluate the corneal sub-basal nerve plexus in patients presenting with hypoesthesia following surgery for trigeminal neuralgia. METHODS: Twenty-one patients who had unilateral medically uncontrolled trigeminal neuralgia and underwent ipsilateral surgery from 2006 to 2012 were included. Of these, 10 had microvascular decompression (MVD group) and 11 had balloon compression of the trigeminal ganglion (BC group). Slit lamp examination, Cochet-Bonnet aesthesiometery and in vivo confocal microscopy were carried out on both eyes of each patient...
February 2016: Acta Ophthalmologica
Rajbir Kaur, Anish Dua
The present study was aimed to evaluate the effect of municipal wastewater of Tung Dhab drain on morphology of scale melanophores in freshwater fish Labeo rohita (Ham.). Chronic, non-renewal toxicity tests were performed with sub lethal concentrations (17.7, 26.6 and 35.4%) of wastewater for exposure durations of 15, 30 and 60 days. Recovery experiments were also performed for duration of 60 days. The scales were removed, processed and diameters of melanophores were measured using an ocular micrometer. The results showed concentration and duration dependent changes in melanophore morphology (size and dendricity) in experimental fish as compared to control fish...
March 2015: Environmental Toxicology and Pharmacology
Harminder S Dua, Ahmad Muneer Otri, Andrew Hopkinson, Imran Mohammed
PURPOSE: Human β-defensins (HBDs) are an important part of the innate immune host defense at the ocular surface. Unlike other defensins, expression of HBD9 at the ocular surface is reduced during microbial infection, but activation of toll-like receptor 2 (TLR2) in corneal epithelial cells has been shown to up-regulate HBD9. Our purpose was to test the hypothesis that TLR2 has a key role in the signalling pathway(s) involved in the overexpression or underexpression of HBD9, and accordingly, different pathogens would induce a different expression pattern of HBD9...
July 2014: Transactions of the American Ophthalmological Society
Ciro Costagliola, Mark Batterbury, Harminder Singh Dua, Leonardo Mastropasqua
No abstract text is available yet for this article.
2014: BioMed Research International
Namrata Sharma, Shiv Shankar Lathi, Sri Vatsa Sehra, Tushar Agarwal, Rajesh Sinha, Jeewan S Titiyal, Thirumurthy Velpandian, Radhika Tandon, Rasik B Vajpayee
PURPOSE: To compare the efficacy of umbilical cord serum (UCS) with amniotic membrane transplantation (AMT) in cases of acute ocular chemical burns. METHODS: In a retrospective, interventional, comparative case series, 55 eyes with grades III, IV and V chemical burns (Dua's classification) who presented within 3 weeks of injury were evaluated. Patients were treated with conventional medical (CM group, 20 eyes) management alone or combined with either UCS (UCS group, 17 eyes) or AMT (AMT group, 18 eyes)...
May 2015: British Journal of Ophthalmology
José Manuel Benitez Del Castillo, Thomas Kaercher, Khaled Mansour, Edward Wylegala, Harminder Dua
Meibomian gland dysfunction (MGD) is widespread and has significant impact on patients' quality of life. Eyelid hygiene is the mainstay of treatment but is unstandardized and requires commitment from the patient and encouragement from the ophthalmologist. Blephasteam(®) is an eyelid warming device designed to be an easy-to-use and standardized treatment for MGD. In the present study, 73 patients were treated for 21 days with twice daily Blephasteam(®) sessions. The primary efficacy variable, a symptomatology visual analog scale score, declined from 63...
2014: Clinical Ophthalmology
J Timkovič, P Smehlík, D Cholevík, J Němčanský, R Kiszová, P Mašek
OBJECTIVE: to investigate and analyze the group of child patients with ocular trauma in the Ostrava region in the Czech Republic. METHODS: A retrospective observational case series. We reviewed and analyzed clinical records of all the paediatric patients with ocular trauma treated at the University Hospital Ostrava in the years 2007 - 2011. Age, sex, mechanism of injury, type of ocular trauma, the consequences of injury and period of the year when the accident occurred were evaluated...
October 2013: Ceská a Slovenská Oftalmologie
Qing Guo, Yuli Pi, Ying Dong, Jing Zhu
PURPOSE: To evaluate the clinical outcomes of tissue-engineered epithelium transplantation for severe ocular surface burns. METHODS: This was a retrospective observational case series. From October 2005 to May 2011, 19 eyes of 19 patients with grade IV to VI ocular surface burns (Dua Classification) were treated by autologous transplantation of corneal stem cells cultivated on a fibrin gel membrane, with a mean follow-up of 16.2 months (range 12-36 months). Postoperative corneal surface stability, visual acuity (VA), corneal opacity, and neovascularization were evaluated...
March 2013: Eye Science
Claire L Allen, Gerry Clare, Elizabeth A Stewart, Matthew J Branch, Owen D McIntosh, Megha Dadhwal, Harminder S Dua, Andrew Hopkinson
PURPOSE: Dried amniotic membrane (AM) can be a useful therapeutic adjunct in ophthalmic surgery and possesses logistical advantages over cryopreserved AM. Differences in preservation techniques can significantly influence the biochemical composition and physical properties of AM, potentially affecting clinical efficacy. This study was established to investigate the biochemical and structural effects of drying AM in the absence and presence of saccharide lyoprotectants and its biocompatibility compared to cryopreserved material...
2013: PloS One
Bina B Kulkarni, Desmond G Powe, Andrew Hopkinson, Harminder S Dua
BACKGROUND: The most important challenge of performing insitu transcriptional profiling of the human ocular surface epithelial regions is obtaining samples in sufficient amounts, without contamination from adjacent tissue, as the region of interest is microscopic and closely apposed to other tissues regions. We have effectively collected ocular surface (OS) epithelial tissue samples from the Limbal Epithelial Crypt (LEC), limbus, cornea and conjunctiva of post-mortem cadaver eyes with laser microdissection (LMD) technique for gene expression studies with spotted oligonucleotide microarrays and Gene 1...
2013: BMC Ophthalmology
U Fares, A A Mokashi, M S Elalfy, H S Dua
AIMS: In a previous study, we proposed that corneal topography performed 30-40 min after the initial suture removal can identify the next set of sutures requiring removal, for the treatment of post-keratoplasty astigmatism. The aim of this study was to evaluate the effect of removing subsequent sets of sutures at the same sitting. METHODS: 10/0 nylon interrupted sutures were placed, to secure the graft-host junction, at the time of keratoplasty. Topography was performed using Pentacam (Oculus) before suture removal...
September 2013: Eye
Fabiana dos Santos Paris, Eliana Domingues Gonçalves, Mauro Silveira de Queiroz Campos, Elcio Hideo Sato, Harminder S Dua, José Álvaro Pereira Gomes
PURPOSE: To compare amniotic membrane transplantation (AMT) and anterior stromal puncture (ASP) in the management of pain in patients with symptomatic bullous keratopathy (BK). METHODS: In this prospective comparative study, 40 eyes of 40 patients with symptomatic BK (chronic intermittent pain) were randomised and divided into two groups (AMT and ASP) according to the technique used to treat symptomatic BK. The patients were examined on days 1, 14, 30, 90 and 180 postoperatively...
August 2013: British Journal of Ophthalmology
John V Forrester, Raymond J Steptoe, Izabela P Klaska, Cristina Martin-Granados, Harminder S Dua, Mariapia A Degli-Esposti, Matthew E Wikstrom
Since the plasticity and the potential for re-programming cells has become widely accepted, there has been great interest in cell-based therapies. These are being applied to a range of diseases, not least ocular diseases, where it is assumed that there is a reduced risk of immune rejection although this may be more perceived than real. There are two broad classes of cell-based therapies: those aimed at restoring structure and function of specific tissues and cells; and those directed towards restoring immunological homeostasis by controlling the damaging effects of inflammatory disease...
July 2013: Progress in Retinal and Eye Research
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"