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Dua ocular

Harminder S Dua, Dalia G Said, Elisabeth M Messmer, Maurizio Rolando, Jose M Benitez-Del-Castillo, Parwez N Hossain, Alex J Shortt, Gerd Gerling, Mario Nubile, Francisco C Figueiredo, Saaeha Rauz, Leonardo Mastropasqua, Paolo Rama, Christophe Baudouin
Neurotrophic Keratopathy (NK) refers to a condition where corneal epitheliopathy leading to frank epithelial defect with or without stromal ulceration (melting) is associated with reduced or absent corneal sensations. Sensory nerves serve nociceptor and trophic functions, which can be affected independently or simultaneously. Loss of trophic function and consequent epithelial breakdown exposes the stroma making it susceptible to enzymatic degradation. Nerve pathology can range from attrition to aberrant re-generation with corresponding symptoms from anaesthesia to hyperaesthesia/allodynia...
April 23, 2018: Progress in Retinal and Eye Research
Marco Messina, Harminder S Dua
PURPOSE: To evaluate the effect of once daily administration of chitosan-N-acetylcysteine (Lacrimera® ) in the management of dry eye disease (DED). METHODS: Eighteen patients (3 male, 15 female) aged 25-86 years (mean 61.1) and suffering from moderate to severe DED with superficial punctate keratitis (SPK) were retrospectively evaluated after a trial of Lacrimera® drops (1 drop in the morning for 5 days only). All the patients were using other artificial tears before the treatment...
March 16, 2018: International Ophthalmology
Prachi Dua, Roman Shinder, Derek B Laskar, Douglas R Lazzaro, Allison E Rizzuti
Purpose: To report a case of hypertrophic herpes simplex virus (HSV) of the eyelid and cornea masquerading as IgG4-related disease. Observations: A 37-year old African American female with a past medical history of human immunodeficiency virus (HIV) on highly active antiretroviral therapy (HAART) and a recent history of treated genital herpes, presented with an ulcerative lesion of the left upper and lower eyelids, and severe ocular inflammation with symblepharon...
March 2018: American Journal of Ophthalmology Case Reports
Jennifer P Craig, Kelly K Nichols, Esen K Akpek, Barbara Caffery, Harminder S Dua, Choun-Ki Joo, Zuguo Liu, J Daniel Nelson, Jason J Nichols, Kazuo Tsubota, Fiona Stapleton
The goals of the TFOS DEWS II Definition and Classification Subcommittee were to create an evidence-based definition and a contemporary classification system for dry eye disease (DED). The new definition recognizes the multifactorial nature of dry eye as a disease where loss of homeostasis of the tear film is the central pathophysiological concept. Ocular symptoms, as a broader term that encompasses reports of discomfort or visual disturbance, feature in the definition and the key etiologies of tear film instability, hyperosmolarity, and ocular surface inflammation and damage were determined to be important for inclusion in the definition...
July 2017: Ocular Surface
Imran Mohammed, Dalia G Said, Harminder S Dua
Sight depends on the passage of light through the transparent cornea and being focused on the fovea. Its exposed position renders it vulnerable to microbial infection. The cornea has developed a wide array of defense mechanisms against infection, of which endogenous antimicrobial peptides (AMPs) are key. AMPs are essentially small molecular weight cationic peptides with a wide range of activity against virus, bacteria, fungi and parasites. Some proteins such as RNases and S100As are also included in this group...
November 2017: Progress in Retinal and Eye Research
Elisabetta Prina, Pritesh Mistry, Laura E Sidney, Jing Yang, Ricky D Wildman, Marina Bertolin, Claudia Breda, Barbara Ferrari, Vanessa Barbaro, Andrew Hopkinson, Harminder S Dua, Stefano Ferrari, Felicity R A J Rose
In recent years, there has been increased research interest in generating corneal substitutes, either for use in the clinic or as in vitro corneal models. The advancement of 3D microfabrication technologies has allowed the reconstruction of the native microarchitecture that controls epithelial cell adhesion, migration and differentiation. In addition, such technology has allowed the inclusion of a dynamic fluid flow that better mimics the physiology of the native cornea. We review the latest innovative products in development in this field, from 3D microfabricated hydrogels to microfluidic devices...
June 2017: Stem Cell Reviews
Geetha Iyer, Bhaskar Srinivasan, Shweta Agarwal, Anil Tarigopula
PURPOSE: To analyse the outcome of allo simple limbal epithelial transplantation (alloSLET) in eyes in the early stage following ocular chemical injury to achieve rapid epithelialisation. PATIENTS AND METHODS: Records of 18 eyes of 17 patients who underwent alloSLET between April 2013 and Jan 2016 were analysed retrospectively. Patients with grade 4 or worse Dua's classification for chemical injury, who presented within a month of the injury or with a non-healing epithelial defect since the injury despite earlier medical or surgical interventions, were included in the study...
June 2017: British Journal of Ophthalmology
B Iaccheri, G Torroni, C Cagini, T Fiore, A Cerquaglia, M Lupidi, S Cillino, H S Dua
PurposeTo investigate the effect of cyclosporine on corneal ultrastructure and on major signs and symptoms of patients with dry eye disease.Patients and methodsIn this prospective cohort study, patients with dry eye disease were treated with a drop of cyclosporine 0.05% twice daily. Clinical evaluation was carried out at baseline and at months 1, 3, and 6. All patients completed the Ocular Surface Disease Index (OSDI) questionnaire, and tear film break-up time (BUT), fluorescein and lissamine green staining, and Schirmer test were carried out...
May 2017: Eye
Harminder S Dua, Ammar Miri, Mohamed S Elalfy, Anna Lencova, Dalia G Said
AIMS: To develop a technique using amniotic membrane (AM) to prevent admixture of conjunctival epithelial cells and limbal explant-derived corneal epithelial cells in patients undergoing limbal stem cell transplantation. To compare this technique with the current method of 'sequential sector conjunctival epitheliectomy' (SSCE). METHODS: 26 patients with total limbal stem cell deficiency who underwent ocular surface reconstruction with limbal stem cells transplantation were retrospectively studied...
July 2017: British Journal of Ophthalmology
A M Yeung, L A Faraj, O D McIntosh, V K Dhillon, H S Dua
PurposeFibrin glue has been used successfully in numerous ophthalmic surgical procedures. Recently, fibrin glue has been used in limbal stem cell transplantation to reduce both operative time and to negate the need for sutures. The aim of this study was to determine the effects of fibrin glue on epithelial cell migration in vitro.MethodsCorneoscleral rims were split to retain the epithelial layer, Bowman's layer, and anterior stroma. Rims were cut into eight equal-sized pieces and were placed directly on culture plates or affixed with fibrin glue...
October 2016: Eye
Namrata Sharma, Divya Singh, Prafulla K Maharana, Alka Kriplani, Thirumurthy Velpandian, Ravindra Mohan Pandey, Rasik B Vajpayee
PURPOSE: To compare the efficacy of topical umbilical cord serum drops (UCS) and amniotic membrane transplantation (AMT) in acute ocular chemical burns. DESIGN: Randomized controlled trial. METHODS: setting: Tertiary care hospital. STUDY POPULATION: Forty-five eyes with acute chemical burns of grade III, IV, and V (Dua's classification) presenting within the first week of injury were randomized into 3 groups (15 each)...
August 2016: American Journal of Ophthalmology
Henrike Westekemper, Francisco C Figueiredo, We Fong Siah, Nina Wagner, Klaus-Peter Steuhl, Daniel Meller
BACKGROUND: Amniotic membrane transplantation (AMT) has been used in the management of acute ocular chemical burns to promote epithelialisation, reduce inflammation and restore ocular surface integrity. The aim of this study is to analyse the morphological and functional outcomes of patients receiving AMT after ocular chemical burn. METHODS: We performed a retrospective analysis of all patients treated for acute ocular chemical burn between 1998 and 2008 in two participating centres (University of Duisburg-Essen, Germany and Royal Victoria Infirmary, Department of Ophthalmology, Newcastle University, UK)...
February 2017: British Journal of Ophthalmology
Wendy Chao, Carlos Belmonte, José M Benitez Del Castillo, Anthony J Bron, Harminder S Dua, Kelly K Nichols, Gary D Novack, Stefan Schrader, Mark D Willcox, James S Wolffsohn, David A Sullivan
On March 21, 2015, a meeting was held in London, United Kingdom, to address the progress in targeting the unmet need for dry eye disease (DED) treatment. The meeting, which launched the i(2) = initiating innovation series, was sponsored by the Tear Film & Ocular Surface Society (TFOS; and supported by Dompé. The TFOS i(2) meeting was designed to review advances in the understanding of DED since publication of the 2007 TFOS International Dry Eye WorkShop (DEWS) report, and to help launch the highly anticipated sequel, DEWS II...
April 2016: Ocular Surface
Vikas Mittal, Rajat Jain, Ruchi Mittal, Urvish Vashist, Purvasha Narang
AIM: To study the outcomes of simple limbal epithelial transplantation (SLET) for unilateral total limbal stem cell deficiency (LSCD) secondary to severe ocular surface burns in children. METHODS: Retrospective interventional case series was performed at a private referral tertiary care centre. Children less than 15 years of age who underwent autologous SLET for total LSCD and had a minimum follow-up of 6 months were included in the study. Demographic and clinical data were recorded in a predesigned form...
August 2016: British Journal of Ophthalmology
J Mayouego Kouam, E Epée, S Azria, D Enyama, A Omgbwa Eballe, C Ebana Mvogo, M Cherifi
INTRODUCTION: Ocular and orbital trauma is a leading cause of acquired monocular blindness in childhood. These injuries differ from those in adults in some aspects of the management and prognosis, notably the risk of amblyopia. The goal of this study was to analyze the epidemiological, clinical and therapeutic features of ocular trauma in children who consulted in an eye emergency department in Île-de-France. PATIENTS AND METHODS: This was a descriptive, prospective and longitudinal study...
October 2015: Journal Français D'ophtalmologie
Ravi Sheshala, Yong Y Kok, Jun M Ng, Raghu R S Thakur, Kamal Dua
Ophthalmic drug delivery system is very interesting and challenging due to the normal physiologically factor of eyes which reduces the bioavailability of ocular products. The development of new ophthalmic dosage forms for existing drugs to improve efficacy and bioavailability, patient compliance and convenience has become one of the main trend in the pharmaceuticals industry. The present review encompasses various conventional and novel ocular drug delivery systems, methods of preparation, characterization and recent research in this area...
2015: Recent Patents on Drug Delivery & Formulation
Virinder K Dhillon, Mohamed S Elalfy, Mouhamed Al-Aqaba, Ankur Gupta, Surajit Basu, Harminder S Dua
PURPOSE: To evaluate the corneal sub-basal nerve plexus in patients presenting with hypoesthesia following surgery for trigeminal neuralgia. METHODS: Twenty-one patients who had unilateral medically uncontrolled trigeminal neuralgia and underwent ipsilateral surgery from 2006 to 2012 were included. Of these, 10 had microvascular decompression (MVD group) and 11 had balloon compression of the trigeminal ganglion (BC group). Slit lamp examination, Cochet-Bonnet aesthesiometery and in vivo confocal microscopy were carried out on both eyes of each patient...
February 2016: Acta Ophthalmologica
Rajbir Kaur, Anish Dua
The present study was aimed to evaluate the effect of municipal wastewater of Tung Dhab drain on morphology of scale melanophores in freshwater fish Labeo rohita (Ham.). Chronic, non-renewal toxicity tests were performed with sub lethal concentrations (17.7, 26.6 and 35.4%) of wastewater for exposure durations of 15, 30 and 60 days. Recovery experiments were also performed for duration of 60 days. The scales were removed, processed and diameters of melanophores were measured using an ocular micrometer. The results showed concentration and duration dependent changes in melanophore morphology (size and dendricity) in experimental fish as compared to control fish...
March 2015: Environmental Toxicology and Pharmacology
Harminder S Dua, Ahmad Muneer Otri, Andrew Hopkinson, Imran Mohammed
PURPOSE: Human β-defensins (HBDs) are an important part of the innate immune host defense at the ocular surface. Unlike other defensins, expression of HBD9 at the ocular surface is reduced during microbial infection, but activation of toll-like receptor 2 (TLR2) in corneal epithelial cells has been shown to up-regulate HBD9. Our purpose was to test the hypothesis that TLR2 has a key role in the signalling pathway(s) involved in the overexpression or underexpression of HBD9, and accordingly, different pathogens would induce a different expression pattern of HBD9...
July 2014: Transactions of the American Ophthalmological Society
Ciro Costagliola, Mark Batterbury, Harminder Singh Dua, Leonardo Mastropasqua
No abstract text is available yet for this article.
2014: BioMed Research International
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