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https://www.readbyqxmd.com/read/29147448/lessons-from-managing-the-breast-malignant-adenomyoepithelioma-and-the-discussion-on-treatment-strategy
#1
Zhu Yuan, Xiang Qu, Zhong-Tao Zhang, Wen G Jiang
This study set out to investigate the clinical diagnosis and treatment strategies for malignant breast adenomyoepithelioma (AME), thus increasing the clinical knowledge on such disease. Two patients with malignant breast AME in Beijing Friendship Hospital were selected for study. Here we report the diagnosis and treatment processes in terms of the failure experience and lessons and relate our findings to those in the literature. Malignant breast AME is inclined to affect the areola area. It is recommended to conduct simple mastectomy combined with sentinel lymph node dissection due to the low sensitivity of the preoperative imaging diagnosis and difficulty in the pathological diagnosis...
August 2017: World Journal of Oncology
https://www.readbyqxmd.com/read/29142748/intraoperative-prediction-of-the-two-axillary-lymph-node-macrometastases-threshold-in-patients-with-breast-cancer-using-a-one-step-nucleic-acid-cytokeratin-19-amplification-assay
#2
Victoria Fung, Stan Kohlhardt, Patricia Vergani, Gregory J Zardin, Norman R Williams
The aim of the present study was to assess the sensitivity, specificity and practicality of using a one-step nucleic acid amplification (OSNA) assay during breast cancer staging surgery to predict and discriminate between at least 2 involved nodes and more than 2 involved nodes and facilitate the decision to provide axillary conservation in the presence of a low total axillary node tumour burden. A total of 700 consecutive patients, not treated with neo-adjuvant chemotherapy, received intraoperative sentinel lymph node (SLN) analysis using OSNA for cT1-T3 cN0 invasive breast cancer...
November 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/29134954/completion-axillary-lymph-node-dissection-can-be-avoid-in-patients-with-invasive-breast-cancer-and-sentinel-lymph-node-micrometastases
#3
Calogero Cipolla, Giuseppa Graceffa, Sergio Calamia, Stefania Latteri, Marco Vito Marino, Mario Latteri, Salvatore Vieni
BACKGROUND: The prognostic value of sentinel lymph node (SLN) micrometastases in invasive breast cancer patients is still widely debated. Even if, in the absence of unequivocal guidelines, the axillary lynphadenectomy is not still performed in the routine clinical care of these patients. MATERIALS AND METHOD: We have retrospectively analyzed 897 patients with operable invasive breast cancer and clinically negative axillary lymph nodes underwent conservative surgery or total mastectomy with SLN biopsy...
November 14, 2017: Annali Italiani di Chirurgia
https://www.readbyqxmd.com/read/29134374/ultrasound-guided-restaging-and-localization-of-axillary-lymph-nodes-after-neoadjuvant-chemotherapy-for-guidance-of-axillary-surgery-in-breast-cancer-patients-experience-with-activated-charcoal
#4
Won Hwa Kim, Hye Jung Kim, Jin Hyang Jung, Ho Yong Park, Jeeyeon Lee, Wan Wook Kim, Ji Young Park, Yee Soo Chae, Soo Jung Lee
OBJECTIVE: The aim of this study was to review our experience with ultrasound (US)-guided localization of axillary lymph nodes using activated charcoal for the guidance of axillary surgery after neoadjuvant chemotherapy (NAC) in clinically node-positive breast cancer patients. METHODS: Between April 2016 and April 2017, US-guided localization of the most suspicious axillary lymph nodes at restaging US using activated charcoal (Charcotrace™) was performed in 45 consecutive, clinically node-positive breast cancer patients who had less than two suspicious nodes after NAC and axillary surgery with sentinel node biopsy...
November 13, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29132268/simplifying-logistics-and-avoiding-the-unnecessary-in-patients-with-breast-cancer-undergoing-sentinel-node-biopsy-a-prospective-feasibility-trial-of-the-preoperative-injection-of-super-paramagnetic-iron-oxide-nanoparticles
#5
A Karakatsanis, H Olofsson, P Stålberg, L Bergkvist, S Abdsaleh, F Wärnberg
PURPOSE: Sentinel node is routinely localized with the intraoperative use of a radioactive tracer, involving challenging logistics. Super paramagnetic iron oxide nanoparticle is a non-radioactive tracer with comparable performance that could allow for preoperative localization, would simplify the procedure, and possibly be of value in axillary mapping before neoadjuvant treatment. The current trial aimed to determine the a priori hypothesis that the injection of super paramagnetic iron oxide nanoparticles in the preoperative period for the localization of the sentinel node is feasible...
November 1, 2017: Scandinavian Journal of Surgery: SJS
https://www.readbyqxmd.com/read/29132012/distinct-ezrin-truncations-differentiate-metastases-in-sentinel-lymph-nodes-from-unaffected-lymph-node-tissues-from-primary-breast-tumors-and-from-healthy-glandular-breast-tissues
#6
Claudia Röwer, Christian George, Toralf Reimer, Bernd Stengel, Anngret Radtke, Bernd Gerber, Michael O Glocker
BACKGROUND: Lymph node metastasis status is a prognostic factor for further lymph node involvement and for patient survival in breast cancer patients. Frozen section analysis of lymph nodes is a reliable method for detection of macro-metastases. However, this method is far less effective in detecting micro-metastases, requesting improved diagnostic procedures. METHODS: We investigated expression and truncation of ezrin in (i) sentinel lymph node metastases, (ii) unaffected axillary lymph nodes, (iii) primary breast tumors, and (iv) healthy glandular breast tissues using 2D gel electrophoresis, SDS-PAGE, and mass spectrometry in addition to Western blotting...
November 10, 2017: Translational Oncology
https://www.readbyqxmd.com/read/29131021/a-novel-color-fluorescence-navigation-system-for-intraoperative-transcutaneous-lymphatic-mapping-and-resection-of-sentinel-lymph-nodes-in-breast-cancer-comparison-with-the-combination-of-gamma-probe-scanning-and-visible-dye-methods
#7
Norihiro Hokimoto, Takeki Sugimoto, Tsutomu Namikawa, Taku Funakoshi, Toyokazu Oki, Maho Ogawa, Hideo Fukuhara, Keiji Inoue, Takayuki Sato, Kazuhiro Hanazaki
BACKGROUND: This study evaluated the clinical efficacy of a novel imaging system (HyperEye Medical System [HEMS]; Mizuho Corp., Tokyo, Japan) that uses the near-infrared (NIR) fluorescence of indocyanine green to analyze sentinel lymph node (SLN) biopsies for the staging of breast cancer. METHODS: This study enrolled 91 patients with histologically confirmed breast cancer that was clinically node negative with a tumor size <3 cm. We compared SLN identification rates between HEMS and conventional methods (gamma probe scanning using a colloidal radioisotope [RI] and a blue dye method) by analyzing the relationships of lymphatic to axillary lesions and SLNs...
November 10, 2017: Oncology
https://www.readbyqxmd.com/read/29129549/application-of-acosog-z1071-effect-of-results-on-patient-care-and-surgical-decision-making
#8
Jacquelyn A V Palmer, Teresa Flippo-Morton, Kendall K Walsh, Lejla Hadzikadic Gusic, Terry Sarantou, Myra M Robinson, Richard L White
BACKGROUND: The ACOSOG (American College of Surgeons Oncology Group) Z1071 assessed the feasibility of performing sentinel lymph node biopsy (SLNB) in node-positive patients who completed neoadjuvant chemotherapy (NACT). Historically, adoption of clinical research into practice takes years. The goal of this study was to determine the effect of Z1071 on our practice. MATERIALS AND METHODS: This is a retrospective review of Z1071's influence on a single institution's practice...
October 12, 2017: Clinical Breast Cancer
https://www.readbyqxmd.com/read/29125333/enhanced-pre-operative-axillary-staging-using-intradermal-microbubbles-and-contrast-enhanced-ultrasound-to-detect-and-biopsy-sentinel-lymph-nodes-in-breast-cancer-a-potential-replacement-for-axillary-surgery
#9
Karina Cox, Sian Taylor-Phillips, Nisha Sharma, Jennifer Weeks, Philippa Mills, Ali Sever, Adrian Lim, Isobel Haigh, Mohamed Hashem, Tania D'Silva, Keshthra Satchithananda, Mengxing Tang, Matthew Wallis
OBJECTIVE: To compare the experience of 4 UK Centres in the use of intradermal microbubbles and contrast enhanced ultrasound (CEUS) to pre-operatively identify and biopsy sentinel lymph nodes (SLN) in patients with breast cancer. METHODS: In all centres, breast cancer patients had a microbubble/ CEUS SLN core biopsy prior to axillary surgery and patients in Centres 1 and 2 had a normal grey-scale axillary ultrasound. Data was collected between 2010 and 2016; 1361 from Centre 1 (prospective, sequential), 376 from Centre 2 (retrospective, sequential), 122 from Centre 3 (retrospective, selected) and 48 from Centre 4 (prospective, selected)...
November 10, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/29124038/intraoperative-radiation-for-breast-cancer-with-intrabeam%C3%A2-factors-associated-with-decreased-operative-times-in-patients-having-iort-for-breast-cancer
#10
Stephanie A Valente, Alicia Fanning, Robyn A Stewart, Sharon Grundfest, Rahul D Tendulkar, Sheen Cherian, Chirag Shah, Chao Tu, Courtney Yanda, Diane Radford, Zahraa Al-Hilli, Stephen R Grobmyer
Introduction: Intraoperative radiation with Intrabeam™ (IORT) for breast cancer is a newer technology recently implemented into the operating room (OR). This procedure requires time and coordination between the surgeon and radiation oncologist, who both perform their treatments in a single operative setting. We evaluated the surgeons at our center, who perform IORT and their OR times to examine changes in OR times following implementation of this new surgical procedure. We hypothesized that IORT is a technique for which timing could be improved with the increasing number of cases performed...
2017: Frontiers in Oncology
https://www.readbyqxmd.com/read/29119692/impact-of-same-day-vs-day-before-pre-operative-lymphoscintigraphy-for-sentinel-lymph-node-biopsy-for-early-breast-cancer-local-australian-experience
#11
Yang Yang Huang, Amelie Maurel, Saud Hamza, Lee Jackson, Zeyad Al-Ogaili
INTRODUCTION: To assess the impact of delayed vs immediate pre-operative lymphoscintigraphy (LSG) for sentinel lymph node biopsy in a single Australian tertiary breast cancer centre. METHODS: Retrospective cohort study analysing patients with breast cancer or DCIS who underwent lumpectomy or mastectomy with pre-operative LSG and intra-operative sentinel lymph node biopsy from January 2015 to June 2016. RESULTS: A total of 182 LSG were performed...
November 9, 2017: Journal of Medical Imaging and Radiation Oncology
https://www.readbyqxmd.com/read/29116108/precision-targeting-of-tumor-macrophages-with-a-cd206-binding-peptide
#12
Pablo Scodeller, Lorena Simón-Gracia, Sergei Kopanchuk, Allan Tobi, Kalle Kilk, Pille Säälik, Kaarel Kurm, Mario Leonardo Squadrito, Venkata Ramana Kotamraju, Ago Rinken, Michele De Palma, Erkki Ruoslahti, Tambet Teesalu
Tumor-associated macrophages (TAMs) expressing the multi-ligand endocytic receptor mannose receptor (CD206/MRC1) contribute to tumor immunosuppression, angiogenesis, metastasis, and relapse. Here, we describe a peptide that selectively targets MRC1-expressing TAMs (MEMs). We performed in vivo peptide phage display screens in mice bearing 4T1 metastatic breast tumors to identify peptides that target peritoneal macrophages. Deep sequencing of the peptide-encoding inserts in the selected phage pool revealed enrichment of the peptide CSPGAKVRC (codenamed "UNO")...
November 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29113649/endoscopic-sentinel-lymph-node-biopsy-and-endoscopic-axillary-lymphadenectomy-without-liposuction-in-patients-with-early-stage-breast-cancer
#13
Jing Fang, Li Ma, Yong-Hui Zhang, Zheng-Jun Yang, Yue Yu, Xu-Chen Cao
BACKGROUND: Our purpose was to present a new method of endoscopic sentinel lymph node biopsy (ESLNB) and endoscopic axillary lymphadenectomy (EALND) without liposuction for treating early-stage breast cancer, and compare results with traditional open dissection. METHODS: The medical records of patients with early-stage breast cancer who underwent EALND/ESLNB without liposuction or traditional open dissection between March 2015 and September 2016 were retrospectively reviewed...
December 2017: Surgical Oncology
https://www.readbyqxmd.com/read/29113416/internal-mammary-lymph-nodes-radiotherapy-of-breast-cancer-in-the-era-of-individualized-medicine
#14
REVIEW
Bin-Bin Cong, Xiao-Shan Cao, Lu Cao, Hui Zhu, Yi-Shan Yu, Jin-Ming Yu, Yong-Sheng Wang
Inclusion internal mammary lymph nodes as a part of regional nodal irradiation have a potential to reduce local recurrence, distant recurrence, and improve survival in breast cancer. However, the increased risk of cardiac toxicity and lungs injure associated with internal mammary lymph nodes irradiation has drew more and more attention. Estimating risk of metastasis in internal mammary lymph nodes based on axillary lymph nodes metastasis status is not always reliable: low-risk do not always mean negative in internal mammary lymph nodes and high-risk do not always indicate positive in internal mammary lymph nodes...
October 6, 2017: Oncotarget
https://www.readbyqxmd.com/read/29109950/paget-s-breast-disease-a-case-report-and-review-of-the-literature
#15
S Dubar, M Boukrid, Jean Bouquet de Joliniere, L Guillou, Quoc Duy Vo, A Major, N Ben Ali, F Khomsi, A Feki
Paget's disease of the breast is a rare cancer. This typical clinical case illustrates the different epidemiological, clinical, histological, therapeutic, and evolving aspects of the disease. We report a case of Paget's disease in a 43-year-old woman who presented eczema of the nipple. Mammography and ultrasounds did reveal a lesion in situ. The patient was scheduled for mastectomy and sentinel node biopsy. She had chosen a radical bilateral surgery. The histological diagnosis was Paget's disease of the breast with a carcinoma in situ...
2017: Frontiers in Surgery
https://www.readbyqxmd.com/read/29107433/-use-of-indocyanine-green-angiography-in-oncological-and-reconstructive-breast-surgery
#16
S Struk, J-F Honart, Q Qassemyar, N Leymarie, B Sarfati, H Alkhashnam, C Mazouni, F Rimareix, F Kolb
The Indocyanine green (ICG) is a soluble dye that is eliminated by the liver and excreted in bile. When illuminated by an near-infrared light, the ICG emits fluorescence in the near-infrared spectrum, which can be captured by a near-infrared camera-handled device. In case of intravenous injection, ICG may be used as a marker of skin perfusion. In case of interstitial injection, it may be useful for lymphatic network mapping. In oncological and reconstructive breast surgery, ICG is used for sentinel lymph node identification, to predict mastectomy skin flap necrosis, to assess the perfusion of free flaps in autologous reconstruction and for diagnosis and treatment of upper limb secondary lymphedema...
October 26, 2017: Annales de Chirurgie Plastique et Esthétique
https://www.readbyqxmd.com/read/29104611/frozen-section-evaluation-of-sentinel-lymph-nodes-in-breast-carcinoma-a-retrospective-analysis
#17
Leonardo Russo, Luis Betancourt, Gabriel Romero, Alí Godoy, Laura Bergamo, Rafael Delgado, Ángela Ruiz, Marianna Gutiérrez, Eduardo Salas, Maria Puzzi
Objective: To determine the false-negative rate, sensitivity, and diagnostic accuracy of the frozen section analysis of the sentinel lymph node (SLN) biopsy in early-stage breast cancer compared to the definitive section and to identify the factors that could be associated with the appearance of false-negative cases. Secondarily, to evaluate the pathological results of cases submitted to completion axillary lymph node dissection (ALND) for positive SLN. Methods: We performed a five-year review of cases (2011-2015), including patients with early-stage breast cancer undergoing SLN biopsy, with frozen section evaluation and subsequent definitive pathological analysis...
2017: Ecancermedicalscience
https://www.readbyqxmd.com/read/29100726/expanding-implementation-of-acosog-z0011-in-surgeon-practice
#18
Anna Weiss, Elizabeth A Mittendorf, Sarah M DeSnyder, Rosa F Hwang, Vivian Bea, Isabelle Bedrosian, Karen Hoffman, Beatriz Adrade, Aysegul A Sahin, Henry M Kuerer, Kelly K Hunt, Abigail S Caudle
BACKGROUND: After publication of American College of Surgeons Oncology Group (ACOSOG) Z0011, surgeons at our institution limited axillary surgery to sentinel lymph node dissection (SLND) in 76% of patients meeting trial eligibility criteria. Our study objective was to assess incorporation of the trial data into practice 5 years later. PATIENTS AND METHODS: Patients with clinical T1-2, N0 invasive breast cancer undergoing breast conserving surgery were included. Comparisons were made between patients who underwent axillary lymph node dissection (ALND) and those that had no further surgery...
October 13, 2017: Clinical Breast Cancer
https://www.readbyqxmd.com/read/29100452/clinical-significance-of-mskcc-nomogram-on-guiding-the-application-of-touch-imprint-cytology-and-frozen-section-in-intraoperative-assessment-of-breast-sentinel-lymph-nodes
#19
Lisha Sun, Guanglei Chen, Yizhen Zhou, Lei Zhang, Zining Jin, Weiguang Liu, Guangping Wu, Feng Jin, Kai Li, Bo Chen
The widely practiced intra-operative methods for rapid evaluation and detection of sentinel lymph node (SLN) status include frozen section (FS) and touch imprint cytology (TIC). This study optimized the use of TIC and FS in the intra-operative detection of breast SLNs based on the Memorial Sloan Kettering Cancer Center (MSKCC) nomogram. Three hundred forty-two SLNs were removed from 79 patients. SLN metastatic probability was assessed by the MSKCC nomogram. The SLNs underwent intra-operative TIC and FS, as well as routine post-operative paraffin sections (RPSs)...
September 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/29096643/comparison-of-sentinel-lymph-node-biopsy-guided-by-indocyanine-green-blue-dye-and-their-combination-in-breast-cancer-patients-a-prospective-cohort-study
#20
Jiajia Guo, Houpu Yang, Shu Wang, Yingming Cao, Miao Liu, Fei Xie, Peng Liu, Bo Zhou, Fuzhong Tong, Lin Cheng, Hongjun Liu, Siyuan Wang
BACKGROUND: Recent studies show that near-infrared (NIR) fluorescence imaging using indocyanine green (ICG) has the potential to improve the performance of sentinel lymph node (SLN) mapping. The current cohort study was designed to assess the value of the combination of ICG and methylene blue (MB) dye in patients undergoing SLN biopsy. METHODS: A prospective self-controlled trial was designed to detect the difference in the detection efficacies of ICG, MB, and combined ICG and MB (ICG + MB) navigation methods...
November 2, 2017: World Journal of Surgical Oncology
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