Ying-Xiang Zou, Tian-Nan Xiang, Li-Rong Xu, Huan Zhang, Yu-He Ma, Lu Zhang, Chun-Xian Zhou, Xiao Wu, Qi-Lin Huang, Biao Lei, Jing-Wen Mu, Xiang-Yang Qin, Xin Jiang, Yue-Juan Zheng
Host-directed therapy (HDT) is a new adjuvant strategy that interfere with host cell factors that are required by a pathogen for replication or persistence. In this study, we assessed the effect of dehydrozaluzanin C-derivative (DHZD), a modified compound from dehydrozaluzanin C (DHZC), as a potential HDT agent for severe infection. LPS-induced septic mouse model and Carbapenem resistant Klebsiella pneumoniae (CRKP) infection mouse model was used for testing in vivo. RAW264.7 cells, mouse primary macrophages, and DCs were used for in vitro experiments...
March 25, 2024: International Immunopharmacology