keyword
https://read.qxmd.com/read/38531219/amiodarone-inhibits-the-toll-like-receptor-3-mediated-nuclear-factor-%C3%AE%C2%BAb-signaling-pathway-by-blocking-organelle-acidification
#21
JOURNAL ARTICLE
Yuka Yokota, Keiko Takaki, Kosuke Baba, Saki Sasaki, Hiroyuki Hirano, Hiroyuki Osada, Takao Kataoka
Toll-like receptor (TLR) agonists or pro-inflammatory cytokines converge to activate the nuclear factor κB (NF-κB) signaling pathway, which provokes inflammatory responses. In the present study, we identified amiodarone hydrochloride as a selective inhibitor of the TLR3-mediated NF-κB signaling pathway by screening the RIKEN NPDepo Chemical Library. In human umbilical vein endothelial cells (HUVEC), amiodarone selectively inhibited the expression of intercellular adhesion molecule-1 (ICAM-1) induced by polyinosinic-polycytidylic acid (Poly(I:C)), but not tumor necrosis factor-α, interleukin-1α, or lipopolysaccharide...
March 19, 2024: Biochemical and Biophysical Research Communications
https://read.qxmd.com/read/38531202/dehydrozaluzanin-c-derivative-protects-septic-mice-by-alleviating-over-activated-inflammatory-response-and-promoting-the-phagocytosis-of-macrophages
#22
JOURNAL ARTICLE
Ying-Xiang Zou, Tian-Nan Xiang, Li-Rong Xu, Huan Zhang, Yu-He Ma, Lu Zhang, Chun-Xian Zhou, Xiao Wu, Qi-Lin Huang, Biao Lei, Jing-Wen Mu, Xiang-Yang Qin, Xin Jiang, Yue-Juan Zheng
Host-directed therapy (HDT) is a new adjuvant strategy that interfere with host cell factors that are required by a pathogen for replication or persistence. In this study, we assessed the effect of dehydrozaluzanin C-derivative (DHZD), a modified compound from dehydrozaluzanin C (DHZC), as a potential HDT agent for severe infection. LPS-induced septic mouse model and Carbapenem resistant Klebsiella pneumoniae (CRKP) infection mouse model was used for testing in vivo. RAW264.7 cells, mouse primary macrophages, and DCs were used for in vitro experiments...
March 25, 2024: International Immunopharmacology
https://read.qxmd.com/read/38530681/trends-in-substance-related-visits-among-youth-to-us-children-s-hospitals-2016-2021-an-analysis-of-the-pediatric-health-information-system-database
#23
JOURNAL ARTICLE
Alexis Ball, Scott Hadland, Jonathan Rodean, Matt Hall, Jason Mendoza, Kym Ahrens
PURPOSE: This study evaluates recent trends in substance-related visits among youth visiting children's hospitals. METHODS: We conducted a cross-sectional study of substance-related visits to pediatric hospitals within the Pediatric Health Information System database of youth aged 12-21 years from 2016 through 2021. Substance-related visits were defined as acute visits for International Classification of Diseases, 10th Revision Clinical Modification codes related to substance 'use', dependence, or overdoses for alcohol, cannabis, nicotine, opioids, sedatives, stimulants, hallucinogens, or other substances...
March 25, 2024: Journal of Adolescent Health
https://read.qxmd.com/read/38530299/dynamics-of-neuronal-firing-modulated-by-high-frequency-electrical-pulse-stimulations-at-axons-in-rat-hippocampus
#24
JOURNAL ARTICLE
Zhaoxiang Wang, Zhouyan Feng, Yue Yuan, Zheshan Guo, Jian Cui, Tianzi Jiang
OBJECTIVE: The development of electrical pulse stimulations in brain, including deep brain stimulation (DBS), is promising for treating various brain diseases. However, the mechanisms of brain stimulations are not yet fully understood. Previous studies have shown that the commonly used high-frequency stimulation (HFS) can increase the firing of neurons and modulate the pattern of neuronal firing. Because the generation of neuronal firing in brain is a nonlinear process, investigating the characteristics of nonlinear dynamics induced by HFS could be helpful to reveal more mechanisms of brain stimulations...
March 26, 2024: Journal of Neural Engineering
https://read.qxmd.com/read/38530258/common-oral-conditions-a-review
#25
JOURNAL ARTICLE
Eric T Stoopler, Alessandro Villa, Mohammed Bindakhil, David L Ojeda Díaz, Thomas P Sollecito
IMPORTANCE: Dry mouth, oral candidiasis, and recurrent aphthous ulcers are 3 of the most common oral conditions that may be associated with patient discomfort, decreased quality of life, and morbidity. OBSERVATIONS: In a meta-analysis of 26 population-based cohort and cross-sectional studies, the global prevalence of dry mouth symptoms was 23% (95% CI, 18% to 28%), placing individuals at risk of oral candidiasis, dental caries, dysgeusia, masticatory/speech impairment, and oropharyngeal dysphagia...
March 26, 2024: JAMA
https://read.qxmd.com/read/38530125/disruption-of-awake-sharp-wave-ripples-does-not-affect-memorization-of-locations-in-repeated-acquisition-spatial-memory-tasks
#26
JOURNAL ARTICLE
Lies Deceuninck, Fabian Kloosterman
Storing and accessing memories is required to successfully perform day-to-day tasks, for example for engaging in a meaningful conversation. Previous studies in both rodents and primates have correlated hippocampal cellular activity with behavioral expression of memory. A key role has been attributed to awake hippocampal replay - a sequential reactivation of neurons representing a trajectory through space. However, it is unclear if awake replay impacts immediate future behavior, gradually creates and stabilizes long-term memories over a long period of time (hours and longer), or enables the temporary memorization of relevant events at an intermediate time scale (seconds to minutes)...
March 26, 2024: ELife
https://read.qxmd.com/read/38529428/novel-use-of-clonidine-patch-to-treat-tizanidine-withdrawal
#27
Aaron B Deutsch, Clare F Hartman, Curtis P Flaherty, Natalie E Ebeling-Koning, Gillian A Beauchamp, Kenneth D Katz
Tizanidine is commonly prescribed for muscle spasticity and pain. Yet, withdrawal is rarely reported. Tizanidine stimulates presynaptic α-2 adrenergic and imidazoline receptors decreasing norepinephrine release. Abrupt cessation can cause withdrawal. Current treatment strategies include tapering oral tizanidine or substituting oral clonidine. A 52-year-old male with a history of hypertension, diabetes, coronary artery disease, and chronic back pain presented with altered mental status, agitation, hypertensive emergency (blood pressure: 250/145 mmHg), and tachycardia...
February 2024: Curēus
https://read.qxmd.com/read/38527803/type-i-interferon-regulates-interleukin-1beta-and-il-18-production-and-secretion-in-human-macrophages
#28
JOURNAL ARTICLE
Rodrigo Díaz-Pino, Gillian I Rice, Diego San Felipe, Tamar Pepanashvili, Paul R Kasher, Tracy A Briggs, Gloria López-Castejón
Inflammasomes are immune complexes whose activation leads to the release of pro-inflammatory cytokines IL-18 and IL-1β. Type I IFNs play a role in fighting infection and stimulate the expression of IFN-stimulated genes (ISGs) involved in inflammation. Despite the importance of these cytokines in inflammation, the regulation of inflammasomes by type I IFNs remains poorly understood. Here, we analysed RNA-sequencing data from patients with monogenic interferonopathies and found an up-regulation of several inflammasome-related genes...
June 2024: Life Science Alliance
https://read.qxmd.com/read/38527367/robot-assisted-support-combined-with-electrical-stimulation-for-the-lower-extremity-in-stroke-patients-a-systematic-review
#29
JOURNAL ARTICLE
Cindy J H Rikhof, Yikke Feenstra, Judith F M Fleuren, Jaap H Buurke, Erik C Prinsen, Johan S Rietman, Gerdienke B Prange-Lasonder

The incidence of stroke rising, leading to an increased demand for rehabilitation services. Literature has consistently shown that early and intensive rehabilitation is beneficial for stroke patients. Robot-assisted devices have been extensively studied in this context, as they have the potential to increase the frequency of therapy sessions and thereby the intensity. Robot-assisted systems can be combined with electrical stimulation to further enhance muscle activation and patient compliance. The objective of this study was to review the effectiveness of electrical stimulation combined with all types of robot-assisted technology for lower extremity rehabilitation in stroke patients...
March 25, 2024: Journal of Neural Engineering
https://read.qxmd.com/read/38526882/tracking-the-immediate-and-short-term-effects-of-continuous-theta-burst-stimulation-on-dynamic-brain-states
#30
JOURNAL ARTICLE
Chao Chen, Zhidong Guo, Weiwei Peng, Shengpei Wang, Shuang Qiu, Jing Zhang, Xiaogang Chen, Huiguang He
Continuous Theta Burst Stimulation (cTBS) has been shown to modulate cortical oscillations and induce cortical inhibitory effects. Electroencephalography (EEG) studies have shown some immediate effects of cTBS on brain activity. To investigate both immediate effects and short-term effects of cTBS on dynamic brain changes, cTBS was applied to 22 healthy participants over their left motor cortex. We recorded eyes-open, resting-state EEG and performance in the Nine-Hole Peg Test (NHPT) before cTBS, immediately after cTBS, and 80 minutes after cTBS...
March 25, 2024: IEEE Transactions on Neural Systems and Rehabilitation Engineering
https://read.qxmd.com/read/38526369/five-year-follow-up-of-health-related-quality-of-life-in-differentiated-thyroid-cancer-patients-treated-with-total-thyroidectomy-and-radioiodine-in-sweden-a-nationwide-prospective-cohort-study
#31
JOURNAL ARTICLE
Julia Winter, Erland Axelsson, Linda Björkhem-Bergman, Catharina Ihre Lundgren, Christel Hedman
Background Despite a good prognosis, survivors of differentiated thyroid cancer (DTC) may have reduced health-related quality of life (HRQOL) many years after treatment, and it is unclear how suppression of thyroid stimulating hormone (TSH) may contribute to HRQOL. This study investigated changes in HRQOL in the five years following DTC treatment, the association between HRQOL and TSH suppression, and how HRQOL compares to the general population. Methods In this nationwide prospective cohort study, 487 DTC patients were identified between 2012 and 2017 from all Swedish hospitals treating DTC patients...
March 25, 2024: Thyroid: Official Journal of the American Thyroid Association
https://read.qxmd.com/read/38526060/a-proof-of-concept-study-evaluating-cardiac-compression-techniques-for-cardiopulmonary-resuscitation-in-laying-hens-gallus-gallus
#32
JOURNAL ARTICLE
Jessica Eisenbarth, Charles O Cummings, Elizabeth A Rozanski, Emily Karlin, John Rush
OBJECTIVE: To determine in adult chickens which of 3 CPR techniques, sternal compressions (SC), SC with interposed caudal coelomic compressions (ICCC), or lateral compressions (LC), results in the highest mean systolic (SAP), diastolic (DAP), and mean arterial pressure (MAP) as measured directly from the carotid artery. DESIGN: Prospective, nonblinded, experimental crossover study. SETTING: University teaching hospital laboratory. ANIMALS: Ten retired laying hens...
March 25, 2024: Journal of Veterinary Emergency and Critical Care
https://read.qxmd.com/read/38525540/the-role-of-nano-systems-in-the-delivery-of-glucose-lowering-drugs-for-the-pre-emption-and-treatment-of-diabetes-associated-atherosclerosis
#33
REVIEW
Luke James Conroy, Alyssa McCann, Nan Zhang, Monica de Gaetano
Diabetes is one of the most prevalent diseases worldwide. In recent decades, type-2 diabetes has become increasingly common, particularly in younger individuals. Diabetes leads to many vascular complications, including atherosclerosis. Atherosclerosis is a cardiovascular disease characterized by lipid-rich plaques within the vasculature. Plaques develop over time, restricting blood flow; and can therefore be the underlying cause of major adverse cardiovascular events, including myocardial infarction and stroke...
March 25, 2024: American Journal of Physiology. Cell Physiology
https://read.qxmd.com/read/38525480/new-therapeutic-targets-and-drugs-for-schizophrenia-beyond-dopamine-d2-receptor-antagonists
#34
REVIEW
Aineng Peng, Jianbo Chai, Haiyuan Wu, Bing Bai, Huihui Yang, Weizhi He, Yonghou Zhao
Schizophrenia is a disease with a complex pathological mechanism that is influenced by multiple genes. The study of its pathogenesis is dominated by the dopamine hypothesis, as well as other hypotheses such as the 5-hydroxytryptamine hypothesis, glutamate hypothesis, immune-inflammatory hypothesis, gene expression abnormality hypothesis, and neurodevelopmental abnormality hypothesis. The first generation of antipsychotics was developed based on dopaminergic receptor antagonism, which blocks dopamine D2 receptors in the brain to exert antipsychotic effects...
2024: Neuropsychiatric Disease and Treatment
https://read.qxmd.com/read/38525392/the-efficacy-of-repetitive-transcranial-magnetic-stimulation-rtms-versus-transcranial-direct-current-stimulation-tdcs-on-migraine-headaches-a-randomized-clinical-trial
#35
JOURNAL ARTICLE
Fatemeh Naji, Mohammad Reza Sharbafchi, Fariborz Khorvash, Mohammad R Maracy, Niloofar Ghasemi Mobarak Abadi
BACKGROUND: Non-pharmacologic prophylactic methods for chronic migraine have been developed, including the promising non-invasive techniques of repetitive transcranial magnetic stimulation (rTMS) and transcranial direct-current stimulation (tDCS). This study aimed to compare the efficacy of rTMS and tDCS on pain intensity, the impact of headaches on daily life, anxiety, and depression in migraine headaches patients. MATERIALS AND METHODS: This randomized clinical trial was conducted on 72 patients with migraine headaches, randomly allocated to the rTMS and tDCS groups...
2024: Advanced Biomedical Research
https://read.qxmd.com/read/38525219/probiotic-supplementation-as-an-alternative-to-antibiotics-in-broiler-chickens
#36
JOURNAL ARTICLE
Grzegorz Tomczyk, Jowita Samanta Niczyporuk, Wojciech Kozdruń, Anna Sawicka-Durkalec, Łukasz Bocian, Marcin Barabasz, Marcin Michalski
INTRODUCTION: The broiler chicken digestive tract microbiome maintains the bird's immunity. Its composition has been shown to be important not only for the immune system but also for the gastrointestinal function and productivity of broiler chickens. If the microbiome is populated by supplementation with Lactobacillus, Pediococcus and Saccharomyces spp. - microorganisms with probiotic properties and alternatives to antibiotics - the immune system is stimulated. The use of probiotic supplements in the broiler production cycle can boost bird immunity and prevent adenovirus infection...
March 2024: Journal of Veterinary Research
https://read.qxmd.com/read/38524852/stimulation-of-muscle-protein-synthesis-with-low-dose-amino-acid-composition-in-older-individuals
#37
JOURNAL ARTICLE
David D Church, Arny A Ferrando, Robert R Wolfe
Essential amino acid (EAA)-based compositions have been shown to be effective stimulators of muscle protein synthesis, but the lower limit of effective dosage is not clear. We have used stable isotope tracer methodology to quantify the response of muscle protein fractional synthetic rate (FSR) to a dose of 3.6 g of a high-leucine composition of EAAs plus arginine in older subjects. Muscle protein FSR increased 0.058%/hour over 3 h following consumption. When account was taken of the total muscle mass, this increase in muscle protein FSR represented approximately 80% of ingested EAAs...
2024: Frontiers in Nutrition
https://read.qxmd.com/read/38524120/a-mini-review-phosphodiesterases-in-charge-to-balance-intracellular-camp-during-t-cell-activation
#38
REVIEW
Marie Bielenberg, Roberta Kurelic, Stefan Frantz, Viacheslav O Nikolaev
T-cell activation is a pivotal process of the adaptive immune response with 3',5'-cyclic adenosine monophosphate (cAMP) as a key regulator of T-cell activation and function. It governs crucial control over T-cell differentiation and production of pro-inflammatory cytokines, such as IFN-γ. Intriguingly, levels of intracellular cAMP differ between regulatory (Treg) and conventional T-cells (Tcon). During cell-cell contact, cAMP is transferred via gap junctions between these T-cell subsets to mediate the immunosuppressive function of Treg...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38523313/water-in-oil-adjuvant-challenges-in-fish-vaccination-an-experimental-inactivated-adjuvanted-vaccine-against-betanodavirus-infection-in-senegalese-sole
#39
JOURNAL ARTICLE
Yulema Valero, Sandra Souto, José G Olveira, Carmen López-Vázquez, Carlos P Dopazo, Isabel Bandín
The extensive growth of intensive fish farming has led to a massive spread of infectious diseases. Nervous necrosis virus (NNV) is the causative agent of the viral encephalo- and retinopathy disease which has become a major threat for fish farming all over the globe. The devastating mortality rates recorded in disease outbreaks, especially when infected specimens are at early stages of development, have a high economic impact on the sector. Currently, vaccines are the most cost-effective preventing tool in the fight against viruses...
March 24, 2024: Journal of Fish Diseases
https://read.qxmd.com/read/38522806/low-intensity-transcranial-ultrasound-stimulation-improves-memory-in-vascular-dementia-by-enhancing-neuronal-activity-and-promoting-spine-formation
#40
JOURNAL ARTICLE
Jiamin Pei, Cong Zhang, Xiao Zhang, Zhe Zhao, Xiangjian Zhang, Yi Yuan
Memory is closely associated with neuronal activity and dendritic spine formation. Low-intensity transcranial ultrasound stimulation (TUS) improves the memory of individuals with vascular dementia (VD). However, it is unclear whether neuronal activity and dendritic spine formation under ultrasound stimulation are involved in memory improvement in VD. In this study, we found that seven days of TUS improved memory in VD model while simultaneously increasing pyramidal neuron activity, promoting dendritic spine formation, and reducing dendritic spine elimination...
March 22, 2024: NeuroImage
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