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https://www.readbyqxmd.com/read/29351420/fourth-ventricular-tsh-induces-satiety-and-increases-body-temperature-in-rats
#1
Ulrika Smedh, Karen A Scott, Timothy H Moran
Besides its well-known action to stimulate thyroid hormone release, Thyrotropin mRNA is expressed within the brain and Thyrotropin and its receptor have been shown to be present in brain areas that control feeding and gastrointestinal function. Here, the hypothesis that Thyrotropin acts on receptors in the dorsal hindbrain to alter food intake and/or gastric function was tested. Fourth ventricular injections of Thyrotropin (0.06, 0.6 and 6.0 µg) were given to rats with chronic intracerebroventricular cannulas aimed at the fourth ventricle...
January 3, 2018: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/29351395/macrophage-colony-stimulating-factor-increases-hepatic-macrophage-content-liver-growth-and-lipid-accumulation-in-neonatal-rats
#2
Clare Pridans, Kristin A Sauter, Katharine M Irvine, Gemma M Davis, Lucas Lefevre, Anna Raper, Rocio Rojo, Ajit J Nirmal, Philippa Beard, Michael Cheeseman, David A Hume
Signaling via the colony stimulating factor 1 receptor (CSF1R) controls the survival, differentiation and proliferation of macrophages. Mutations in CSF1, or CSF1R in mice and rats have pleiotropic effects on postnatal somatic growth. We tested the possible application of CSF1-Fc as a therapy for low birth weight (LBW) at term, using a model based upon maternal dexamethasone treatment in rats. Neonatal CSF1-Fc treatment did not alter somatic growth, and did not increase the blood monocyte count. Instead, there was a substantial increase in the size of liver in both control and LBW rats, and the treatment greatly exacerbated the lipid droplet accumulation seen in the dexamethasone LBW model...
December 21, 2017: American Journal of Physiology. Gastrointestinal and Liver Physiology
https://www.readbyqxmd.com/read/29350775/randomized-trial-of-transcranial-dc-stimulation-for-post-stroke-dysphagia
#3
Sonja Suntrup-Krueger, Corinna Ringmaier, Paul Muhle, Andreas Wollbrink, Andre Kemmling, Uta Hanning, Inga Claus, Tobias Warnecke, Inga Teismann, Christo Pantev, Rainer Dziewas
OBJECTIVE: We evaluated whether transcranial direct current stimulation (tDCS) is able to enhance dysphagia rehabilitation following stroke. Besides relating clinical effects with neuroplastic changes in cortical swallowing processing we aimed to identify factors influencing treatment success. METHODS: In this double-blind, randomized study 60 acute dysphagic stroke patients received contralesional anodal (1 mA, 20 min) or sham tDCS on four consecutive days. Swallowing function was thoroughly assessed before and after the intervention using the validated Fiberoptic Endoscopic Dysphagia Severity Scale (FEDSS) and clinical assessment...
January 19, 2018: Annals of Neurology
https://www.readbyqxmd.com/read/29350420/over-expression-of-dec1-inhibits-myogenic-differentiation-by-modulating-myog-activity-in-bovine-satellite-cell
#4
Yongzhen Huang, Xinsheng Lai, Linyong Hu, Chuzhao Lei, Xianyong Lan, Chunlei Zhang, Yun Ma, Li Zheng, Yue-Yu Bai, Fengpeng Lin, Hong Chen
Differentiated embryo chondrocyte 1 (DEC1), a member of basic-helix-loop-helix transcription factor Bhlhe40, also called stimulated by retinoic acid 13, STRA13, plays an important role in the regulation of adipogenesis, tumorigenesis, peripheral circadian output, response to hypoxia and development of metabolic syndrome. Previous studies suggested that DEC1 was involved in skeletal muscle development; however, its precise role in myoblast differentiation has not been determined. In the present study, we showed that DEC1 expressed ubiquitously in different bovine tissues and was down-regulated in differentiated bovine satellite cells...
January 19, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29350183/integrated-biocircuits-engineering-functional-multicellular-circuits-and-devices
#5
Jordan Prox, Tory Smith, Chad Holl, Nick Chehade, Liang Guo
Novel in vitro platforms are currently revolutionizing the study and reconstruction of cellular circuitry to bypass the pertaining obstacles of data retrieval in vivo. While earlier approaches have provided great insights into culturing circuits in planar dissociated cell culture systems, the lack of full control over network activity and formation limits our understanding of their functionality. Thus, integrating various controllable parameters are required in creating a suitable microenvironment including cell patterning, highly-specified electrical and chemical stimuli, and rational circuit formation via logic functions...
January 19, 2018: Journal of Neural Engineering
https://www.readbyqxmd.com/read/29350069/new-and-developing-pharmacotherapy-for-osteoporosis-in-men
#6
Luigi Gennari, John P Bilezikian
Osteoporosis represents a major health and societal burden in men, as well as in women. However, only a minority of men are screened and treated for osteoporosis and fracture prevention, even after first fracture. Areas covered: This article provides a comprehensive summary of the currently available drugs for osteoporosis in men as well as insights into new and developing pharmacotherapy. Expert opinion: To date, therapeutic approaches to osteoporosis in men remain not as well defined as in women, since antifracture efficacy data are lacking for most approved pharmaceuticals...
January 19, 2018: Expert Opinion on Pharmacotherapy
https://www.readbyqxmd.com/read/29350067/soluble-neuregulin1-is-strongly-up-regulated-in-the-rat-model-of-charcot-marie-tooth-1a-disease
#7
Benedetta Elena Fornasari, Giulia Ronchi, Davide Pascal, Davide Visigalli, Giovanna Capodivento, Lucilla Nobbio, Isabelle Perroteau, Angelo Schenone, Stefano Geuna, Giovanna Gambarotta
Neuregulin1 (NRG1) is a growth factor playing a pivotal role in peripheral nerve development through the activation of the transmembrane co-receptors ErbB2-ErbB3. Soluble NRG1 isoforms, mainly secreted by Schwann cells, are strongly and transiently up-regulated after acute peripheral nerve injury, thus suggesting that they play a crucial role also in the response to nerve damage. Here we show that in the rat experimental model of the peripheral demyelinating neuropathy Charcot-Marie-Tooth 1A (CMT1A) the expression of the different NRG1 isoforms (soluble, type α and β, type a and b) is strongly up-regulated, as well as the expression of NRG1 co-receptors ErbB2-ErbB3, thus showing that CMT1A nerves have a gene expression pattern highly reminiscent of injured nerves...
January 1, 2018: Experimental Biology and Medicine
https://www.readbyqxmd.com/read/29349647/behaviour-of-freshwater-snails-radix-balthica-exposed-to-the-pharmaceutical-sertraline-under-simulated-predation-risk
#8
Melanie Lea Hedgespeth, Tomasz Karasek, Johan Ahlgren, Olof Berglund, Christer Brönmark
Due to their potential for affecting the modulation of behaviour, effects of selective serotonin reuptake inhibitors (SSRIs) in the environment are particularly interesting regarding interspecies interactions and non-consumptive effects (NCEs) induced by predator cues in prey organisms. We evaluated the effects of sertraline (0.4, 40 ng/L, 40 µg/L) over 8 days on activity and habitat choice in the freshwater snail Radix balthica, on snails' boldness in response to mechanical stimulation (simulating predator attack), and their activity/habitat choice in response to chemical cues from predatory fish...
January 18, 2018: Ecotoxicology
https://www.readbyqxmd.com/read/29349567/hbeag-induces-the-expression-of-macrophage-mir-155-to-accelerate-liver-injury-via-promoting-production-of-inflammatory-cytokines
#9
Wenwen Wang, Hongjun Bian, Feifei Li, Xiao Li, Di Zhang, Shuohuan Sun, Shouyang Song, Qiang Zhu, Wanhua Ren, Chengyong Qin, Jianni Qi
Activation of Kupffer cells (KCs) induced that inflammatory cytokine production plays a central role in the pathogenesis of HBV infection. The previous studies from our and other laboratory demonstrated miRNAs can regulate TLR-inducing inflammatory responses to macrophage. However, the involvement of miRNAs in HBV-associated antigen-induced macrophage activation is still not thoroughly understood. Here, we evaluated the effects and mechanisms of miR-155 in HBV-associated antigen-induced macrophage activation...
January 18, 2018: Cellular and Molecular Life Sciences: CMLS
https://www.readbyqxmd.com/read/29349552/european-network-of-trainees-in-obstetrics-and-gynaecology-entog-exchange-2017-an-experience-report-from-slovenia-outlining-the-different-trainee-situations-around-europe
#10
Nathalie Rippinger, P Turtiainen, I Šibli, S Keß, Jure Klanjšček, M D'Oliveira, C Schneidinger, M Barbier, D M Bos, J Bartašius, J Puppe, L Gabriel, R Vochem
PURPOSE: The European Network of Trainees in Obstetrics and Gynaecology (ENTOG) is a non-profit, independent organisation that represents young trainees in obstetrics and gynaecology around Europe. At present, ENTOG has 32 member countries. The organisation was founded in 1997 and shall assure the exchange of experiences between young physicians all over Europe. The aim is to improve the quality of traineeship in all participating countries and consequently enhance the standards for women's healthcare...
January 18, 2018: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/29348538/broadband-wave-plates-made-by-plasmonic-metamaterials
#11
Lin Chen, Xianmin Ke, Huijie Guo, Junhao Li, Xun Li, Lei Zhou
Although metamaterials wave-plates have been demonstrated previously, many of them suffer from the issue of narrow bandwidth since they typically rely on resonance principles and thus exhibit inevitable frequency dispersions. Here, we show that the dispersion of spoof surface plasmon (SSP) mode supported by a fishbone structure can be freely modulated by varying the structural parameters. This motivates us to establish a general strategy of building broadband wave-plates by cascading two fishbone structures with different propagation constants of SSP modes...
January 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29347851/the-era-of-biofunctional-biomaterials-in-orthopedics-what-does-the-future-hold
#12
Mubashar Rehman, Asadullah Madni, Thomas J Webster
Titanium-based materials do not fulfill all the requirements of orthopedic implants due to a mismatch in mechanical properties with bone which are prone to change during the course of bone growth. Biofunctional biomaterials are a new class of materials that show bioactivity and adaptability at any stage of bone growth. Areas covered: Different biofunctional biomaterials have evolved over time that can enhance calcium phosphate (CaP) precipitation, stimulate osteogenic differentiation, and can control osteoblast gene expression...
January 18, 2018: Expert Review of Medical Devices
https://www.readbyqxmd.com/read/29347784/parametric-pulse-amplification-by-acoustic-quasimodes-in-electron-positron-plasma
#13
F Schluck, G Lehmann, K H Spatschek
In a recent paper, M. R. Edwards, N. J. Fisch, and J. M. Mikhailova [Phys. Rev. Lett. 116, 015004 (2016)PRLTAO0031-900710.1103/PhysRevLett.116.015004] reported that in electron-positron plasma stimulated Brillouin scattering is drastically enhanced, while stimulated Raman scattering is completely absent. However, when theory was compared to particle-in-cell (PIC) simulations, a discrepancy by at least a factor four appeared. Authors correctly argued that the disparity might be due to the fluid approximation of the low-frequency mode...
November 2017: Physical Review. E
https://www.readbyqxmd.com/read/29346027/postsurgical-outcomes-and-surgical-completeness-of-robotic-thyroid-surgery-a-single-surgeon-s-experience-on-700-cases
#14
Eon-Bin Kim, Jae Won Cho, Yu-Mi Lee, Tae-Yon Sung, Jong Ho Yoon, Ki-Wook Chung, Suck Joon Hong
BACKGROUND: Advanced technology and understanding of robotic surgical system have rendered robotic thyroid surgery more expanding. The aim of this study was to identify the periodic changes in postsurgical outcomes of robotic thyroid surgery performed by a single surgeon. METHODS: We conducted a retrospective review of 700 robotic thyroid surgery cases using gasless trans-axillary approach. RESULTS: All patients underwent successful operations without conversion to open surgery, and were mostly younger than 45 years, female, less-extended thyroid surgery and lymph node dissection, and thyroid cancer...
January 18, 2018: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://www.readbyqxmd.com/read/29345843/does-the-use-of-epiduroscopic-lysis-of-adhesions-reduce-the-need-for-spinal-cord-stimulation-in-failed-back-surgery-syndrome-a-short-term-pilot-study
#15
S J Tuijp, J Van Zundert, P De Vooght, M Puylaert, R Mestrum, R Heylen, P Vanelderen
BACKGROUND AND AIMS: Persistent low back pain after initially successful surgery that is not attributed to structural deficits, is called failed back surgery syndrome (FBSS). When conservative and minimal invasive therapy fail, the recommended treatment is spinal cord stimulation (SCS). Because epidural fibrosis can be a contributing factor in the majority of FBSS patients, lumbosacral epiduroscopic lysis of adhesions may be considered as a less invasive alternative treatment option. We hypothesized that the use of epiduroscopic lysis of adhesions could reduce the need for SCS...
January 18, 2018: Pain Practice: the Official Journal of World Institute of Pain
https://www.readbyqxmd.com/read/29345415/investigating-complications-associated-with-occipital-nerve-stimulation-a-maude-study
#16
REVIEW
Joseph Doran, Max Ward, Brittany Ward, Boris Paskhover, Michael Umanoff, Antonios Mammis
OBJECTIVES: The objectives of this study are to utilize the MAUDE data base to enhance our understanding of the complication profile for Occipital Nerve Stimulation, a therapy for which the current level of evidence is limited. Additionally, it is our objective to describe a systematic approach to processing the MAUDE data, which addresses its flaws and enhances its utility. METHODS: From the FDA website, we accessed adverse events reports from the MAUDE data base for devices used in Occipital Nerve Stimulation between June 30, 2007 and June 30, 2017...
January 18, 2018: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/29345235/news-on-climate-change-air-pollution-and-allergic-trigger-factors-of-asthma
#17
REVIEW
M D Amato, L Cecchi, I Annesi-Maesano, G D Amato
The rising frequency of obstructive respiratory diseases,in particular allergic asthma, observed over the last years, can be partially explained by changes occurring in the environment, with increasing presence in atmosphere of chemical (particulate matter and gaseous components such as nitrogen dioxide and ozone) and biologic (aeroallergens) trigger factors. Aeroallergens are able to stimulate, in allergic subjects, the airways' sensitization, inducing symptoms of bronchial asthma. Over the last 50 years, global earth's temperature has markedly risen likely because of growing emission of anthropogenic greenhouse gas concentrations...
January 17, 2018: Journal of Investigational Allergology & Clinical Immunology
https://www.readbyqxmd.com/read/29345187/the-formation-of-a-medical-student-research-committee-and-its-impact-on-involvement-in-departmental-research
#18
Stuart Schexnayder, Hunter Starring, Matt Fury, Arthur Mora, Claudia Leonardi, Vinod Dasa
Over the past ten years, medical students have increased their research activity to be competitive for orthopaedic residency positions throughout the country. This increase may favor students at institutions with a strong history of research production and well-established research departments with supporting staff. To compete with these institutions, a Musculoskeletal Research Committee was developed at a southern academic institution to provide a mutually beneficial link between orthopaedic research faculty and medical students...
December 2018: Medical Education Online
https://www.readbyqxmd.com/read/29342125/induction-of-pro-apoptotic-endoplasmic-reticulum-stress-in-multiple-myeloma-cells-by-neo214-perillyl-alcohol-conjugated-to-rolipram
#19
Thomas C Chen, Nymph Chan, Shirin Labib, Jiali Yu, Hee-Yeon Cho, Florence M Hofman, Axel H Schönthal
Despite the introduction of new therapies for multiple myeloma (MM), many patients are still dying from this disease and novel treatments are urgently needed. We have designed a novel hybrid molecule, called NEO214, that was generated by covalent conjugation of the natural monoterpene perillyl alcohol (POH), an inducer of endoplasmic reticulum (ER) stress, to rolipram (Rp), an inhibitor of phosphodiesterase-4 (PDE4). Its potential anticancer effects were investigated in a panel of MM cell lines. We found that NEO214 effectively killed MM cells in vitro with a potency that was over an order of magnitude stronger than that of its individual components, either alone or in combination...
January 17, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29342050/intraoperative-cochlear-implant-device-testing-utilizing-an-automated-remote-system-a-prospective-pilot-study
#20
Amanda R Lohmann, Matthew L Carlson, Douglas P Sladen
INTRODUCTION: Intraoperative cochlear implant device testing provides valuable information regarding device integrity, electrode position, and may assist with determining initial stimulation settings. Manual intraoperative device testing during cochlear implantation requires the time and expertise of a trained audiologist. The purpose of the current study is to investigate the feasibility of using automated remote intraoperative cochlear implant reverse telemetry testing as an alternative to standard testing...
January 16, 2018: Otology & Neurotology
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