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https://www.readbyqxmd.com/read/28741573/novel-radiation-dose-reduction-fluoroscopic-technology-facilitates-chronic-total-occlusion-percutaneous-coronary-interventions
#1
Stephen Balter, Matthew Brinkman, Sanjog Kalra, Tamim Nazif, Manish Parikh, Ajay J Kirtane, Jeffrey Moses, Martin B Leon, Angeli Feri, Philip Green, Ziad A Ali, Ming Liao, Dimitrios Karmpaliotis
AIMS: Radiation exposure and prolonged procedure time continue to limit the complexity of CTO-PCI procedures attempted. This study aimed assess the impact of radiation-dose-limiting equipment on radiation dosage and fluoroscopic time in chronic total occlusion (CTO) percutaneous coronary interventions (PCI). METHODS AND RESULTS: Retrospective clinical and dosimetric data from diagnostic catheterizations (DXC) and CTO-PCI procedures performed on one of three variants of interventional fluoroscopic equipment were collected...
July 25, 2017: EuroIntervention
https://www.readbyqxmd.com/read/28737650/thalidomide-in-transfusion-dependent-thalassemia-hope-or-hype
#2
Manas Kalra, Virender K Khanna, Amita Trehan, Amita Mahajan
No abstract text is available yet for this article.
August 2017: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/28735783/myocardial-viability-state-of-the-art-is-it-still-relevant-and-how-to-best-assess-it-with-imaging
#3
REVIEW
Hena Patel, Wojciech Mazur, Kim Allan Williams, Dinesh K Kalra
Despite major advances, ischemic cardiomyopathy (ICM) remains a significant cause of death and disability worldwide, with coronary artery disease (CAD) the leading cause of left ventricular (LV) systolic dysfunction. Coronary revascularization may improve LV function, heart failure symptoms and cardiovascular outcomes in high-risk patients with myocardial viability. Multiple imaging modalities have been utilized to detect viable myocardium and predict functional recovery following revascularization. Dobutamine stress echocardiography (DSE), nuclear imaging and cardiac MRI (CMR) are frequently used to assess viability...
July 10, 2017: Trends in Cardiovascular Medicine
https://www.readbyqxmd.com/read/28734394/low-dose-computed-tomography-for-lung-cancer-screening-the-protocol-and-the-dose
#4
Shaunagh McDermott, Mannudeep K Kalra
No abstract text is available yet for this article.
July 2017: Seminars in Roentgenology
https://www.readbyqxmd.com/read/28730951/penumbra-and-re-canalization-acute-computed-tomography-in-ischemic-stroke-evaluation-practise-study-protocol
#5
Salwa El-Tawil, Joanna Wardlaw, Ian Ford, Grant Mair, Tom Robinson, Lalit Kalra, Keith W Muir
Rationale Multimodal imaging, including computed tomography angiography and computed tomography perfusion imaging, yields additional information on intracranial vessels and brain perfusion and can differentiate between ischemic core and penumbra which may affect patient selection for intravenous thrombolysis. Hypothesis The use of multimodal imaging will increase the number of patients receiving intravenous thrombolysis and lead to better treatment outcomes. Sample size 400 patients. Methods and design PRACTISE is a prospective, multicenter, randomized, controlled trial in which patients presenting within 4...
August 2017: International Journal of Stroke: Official Journal of the International Stroke Society
https://www.readbyqxmd.com/read/28725482/systems-biology-driving-drug-development-from-design-to-the-clinical-testing-of-the-anti-erbb3-antibody-seribantumab-mm-121
#6
REVIEW
Birgit Schoeberl, Art Kudla, Kristina Masson, Ashish Kalra, Michael Curley, Gregory Finn, Emily Pace, Brian Harms, Jaeyeon Kim, Jeff Kearns, Aaron Fulgham, Olga Burenkova, Viara Grantcharova, Defne Yarar, Violette Paragas, Jonathan Fitzgerald, Marisa Wainszelbaum, Kip West, Sara Mathews, Rachel Nering, Bambang Adiwijaya, Gabriela Garcia, Bill Kubasek, Victor Moyo, Akos Czibere, Ulrik B Nielsen, Gavin MacBeath
The ErbB family of receptor tyrosine kinases comprises four members: epidermal growth factor receptor (EGFR/ErbB1), human EGFR 2 (HER2/ErbB2), ErbB3/HER3, and ErbB4/HER4. The first two members of this family, EGFR and HER2, have been implicated in tumorigenesis and cancer progression for several decades, and numerous drugs have now been approved that target these two proteins. Less attention, however, has been paid to the role of this family in mediating cancer cell survival and drug tolerance. To better understand the complex signal transduction network triggered by the ErbB receptor family, we built a computational model that quantitatively captures the dynamics of ErbB signaling...
2017: NPJ Systems Biology and Applications
https://www.readbyqxmd.com/read/28720226/a-comparative-review-of-open-and-endovascular-abdominal-aortic-aneurysm-repairs-in-the-national-operative-quality-improvement-database
#7
Kanika Kalra, Shipra Arya
Repair of abdominal aortic aneurysms with endovascular techniques has emerged as the first line of therapy, due to procedural ease and excellent patient outcomes. Open aneurysm repair is increasingly used as a secondary option for lesions with anatomic complexity that involve arterial branches. Understanding the impact of endovascular abdominal aortic aneurysms repair on the shift in vascular operation practice for abdominal aortic aneurysms repair, requires a comprehensive and risk-adjusted review of operative outcomes between the 2 repair types...
July 15, 2017: Surgery
https://www.readbyqxmd.com/read/28716322/parkinson-s-disease-and-its-effect-on-the-lower-urinary-tract-evaluation-of-complications-and-treatment-strategies
#8
REVIEW
Benjamin M Brucker, Sidhartha Kalra
Parkinson's disease (PD) and atypical Parkinsonism are the second most common neurodegenerative movement disorders. Lower urinary tract dysfunction is among the most common types of associated autonomic dysfunctions. Differentiating the subtypes of PD is important for symptom management and understanding prognosis, because Lower urinary tract symptoms (LUTS) can evolve differently depending on the primary disease. LUTS are caused by storage and/or voiding dysfunctions. Urodynamics is a key investigative tool...
August 2017: Urologic Clinics of North America
https://www.readbyqxmd.com/read/28691946/number-of-bacteria-and-time-of-coincubation-with-bacteria-required-for-the-development-of-acanthamoeba-keratitis
#9
Prabhakar Singh, Paavan Kalra, Bhupesh Bagga, Savitri Sharma
No abstract text is available yet for this article.
July 6, 2017: Cornea
https://www.readbyqxmd.com/read/28688028/novel-assessment-of-interstitial-lung-disease-using-the-computer-aided-lung-informatics-for-pathology-evaluation-and-rating-caliper-software-system-in-idiopathic-inflammatory-myopathies
#10
Patompong Ungprasert, Katelynn M Wilton, Floranne C Ernste, Sanjay Kalra, Cynthia S Crowson, Srinivasan Rajagopalan, Brian J Bartholmai
PURPOSE: To evaluate the correlation between measurements from quantitative thoracic high-resolution CT (HRCT) analysis with "Computer-Aided Lung Informatics for Pathology Evaluation and Rating" (CALIPER) software and measurements from pulmonary function tests (PFTs) in patients with idiopathic inflammatory myopathies (IIM)-associated interstitial lung disease (ILD). METHODS: A cohort of patients with IIM-associated ILD seen at Mayo Clinic was identified from medical record review...
July 7, 2017: Lung
https://www.readbyqxmd.com/read/28672082/toward-an-understanding-of-structural-insights-of-xanthine-and-aldehyde-oxidases-an-overview-of-their-inhibitors-and-role-in-various-diseases
#11
REVIEW
Raj Kumar, Gaurav Joshi, Harveen Kler, Sourav Kalra, Manpreet Kaur, Ramandeep Arya
Almost all drug molecules become the substrates for oxidoreductase enzymes, get metabolized into more hydrophilic products and eliminated from the body. These metabolites sometime may be more potent, active, inactive, or toxic in nature compared to parent molecule. Xanthine oxidoreductase and aldehyde oxidase belong to molybdenum containing family and are well characterized for their structures and functions, in particular to their ability to oxidize/hydroxylate the xenobiotics. Their upregulated clinical levels causing oxidative stress are associated with pathways either directly involved in the progression of diseases, gout, or indirectly with the succession of other diseases such as diabetes, cancer, etc...
July 3, 2017: Medicinal Research Reviews
https://www.readbyqxmd.com/read/28670559/metabolic-karma-in-diabetes-care-medico-philosophical-reflections
#12
Sanjay Kalra, Pallavi Kawatra
No abstract text is available yet for this article.
July 2017: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28670550/thyro-stress
#13
Sanjay Kalra, Komal Verma, Yatan Pal Singh Balhara
Our understanding of the biopsychosocial model of health, and its influence on chronic endocrine conditions, has improved over the past few decades. We can distinguish, for example, between diabetes distress and major depressive disorders in diabetes. Similar to diabetes distress, we suggest the existence of "thyrostress" in chronic thyroid disorders. Thyro-stress is defined as an emotional state, characterized by extreme apprehension, discomfort or dejection, caused by the challenges and demand of living with thyroid disorders such as hypothyroidism...
July 2017: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28670549/medication-counseling-for-thyroxine
#14
Sanjay Kalra, A G Unnikrishnan, Mangesh Tiwaskar, Rakesh Sahay, Banshi Saboo, Vijay Negalur, Deepak Khandelwal, Pritam Gupta, Sujoy Ghosh, A K Das, Ganapathi Bantwal, Sarita Bajaj, Sameer Agarwal, Rashmi Aggarwal, Navneet Agarwal
This communication from the National Indian Patient-centered Thyroid Management group provides a useful tool to help in medication counseling during hypothyroidism management. The authors classify and list aspects of thyroxine use which must be discussed with patients on thyroxine supplementation or replacement. Issues related to concomitant food and medications intake, preconception and pregnancy management, as well as sick day care, are also discussed.
July 2017: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28670547/forum-for-injection-technique-and-therapy-expert-recommendations-india-the-indian-recommendations-for-best-practice-in-insulin-injection-technique-2017
#15
REVIEW
Nikhil Tandon, Sanjay Kalra, Yatan Pal Singh Balhara, Manash P Baruah, Manoj Chadha, Hemraj B Chandalia, K M Prasanna Kumar, S V Madhu, Ambrish Mithal, Rakesh Sahay, Rishi Shukla, Annamalai Sundaram, Ambika G Unnikrishnan, Banshi Saboo, Vandita Gupta, Subhankar Chowdhury, Jothydev Kesavadev, Subhash K Wangnoo
Health-care professionals in India frequently manage injection or infusion therapies in persons with diabetes (PWD). Patients taking insulin should know the importance of proper needle size, correct injection process, complication avoidance, and all other aspects of injection technique from the first visit onward. To assist health-care practitioners in their clinical practice, Forum for Injection Technique and Therapy Expert Recommendations, India, has updated the practical advice and made it more comprehensive evidence-based best practice information...
July 2017: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28670541/occurrence-and-predictors-of-depression-and-poor-quality-of-life-among-patients-with-type-2-diabetes-a-northern-india-perspective
#16
Prerna Bahety, Gunjan Agarwal, Deepak Khandelwal, Deep Dutta, Sanjay Kalra, Pankaj Taparia, Vikas Singhal
BACKGROUND AND AIMS: Globally, depression has been linked to Type-2 diabetes mellitus (T2DM). However, similar data from India are scant. This study evaluated the occurrence and predictors of depression and health-related quality of life (QOL) in patients with T2DM as compared to healthy controls. MATERIALS AND METHODS: One hundred adults with T2DM without prior diagnosis of depression and 100 matched controls were evaluated. Depression was assessed using Patient Health Questionnaire-9...
July 2017: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28670528/diabetes-care-evolution-of-philosophy
#17
EDITORIAL
Sanjay Kalra, Manash P Baruah, Bharti Kalra
No abstract text is available yet for this article.
July 2017: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28670527/thyroid-vigilance
#18
EDITORIAL
Sanjay Kalra, Deepak Khandelwal, Sameer Aggarwal
No abstract text is available yet for this article.
July 2017: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28670526/technosocial-competence-in-diabetology
#19
EDITORIAL
Sanjay Kalra, Karthik Balachandran
No abstract text is available yet for this article.
July 2017: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28660161/posttraumatic-stress-disorder-after-myocardial-infarction-and-coronary-artery-bypass-grafting
#20
REVIEW
Amitoj Singh, Sahil Agrawal, Sanchita Gargya, Sabir Saluja, Akshat Kumar, Abhishek Kumar, Kartik Kalra, Munveer Thind, Sajeev Saluja, Lauren E Stone, Farhan Ali, Rodrigo Duarte-Chavez, Christine Marchionni, Farhad Sholevar, Jamshid Shirani, Sudip Nanda
Post traumatic stress disorder is a psychiatric disease that is usually precipitated by life threatening stressors. Myocardial infarction, especially in the young can count as one such event. The development of post traumatic stress after a coronary event not only adversely effects psychiatric health, but leads to increased cardiovascular morbidity and mortality. There is increasing evidence that like major depression, post traumatic stress disorder is also a strong coronary risk factor. Early diagnosis and treatment of this disease in patients with acute manifestations of coronary artery disease can improve patient outcomes...
April 2017: International Journal of Critical Illness and Injury Science
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