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https://www.readbyqxmd.com/read/29791929/documenting-routinely-what-matters-to-people-standardized-headings-for-health-records-of-patients-with-chronic-health-conditions
#1
Birgit Prodinger, Paul Rastall, Dipak Kalra, Darren Wooldridge, Iain Carpenter
OBJECTIVE:  Specifying the content in electronic health records (EHRs) through standardized headings based on international reference classifications will facilitate their semantic interoperability. The objective of this study was to specify potential chapter headings for EHRs aligned with the World Health Organization's (WHO) International Classification of Functioning, Disability, and Health (ICF) based on the perspectives of people living with chronic health conditions, carers, and professionals...
April 2018: Applied Clinical Informatics
https://www.readbyqxmd.com/read/29779802/feasibility-of-initiating-early-enteral-nutrition-after-congenital-heart-surgery-in-neonates-and-infants
#2
Rajat Kalra, Rohit Vohra, Malti Negi, Reena Joshi, Neeraj Aggarwal, Mridul Aggarwal, Raja Joshi
OBJECTIVE: To assess the feasibility of initiating enteral nutrition support with first 24 h of congenital heart repairs in neonates and Infants and its impact on outcomes following surgery. DESIGN: It is a prospective randomized control single blind study. SETTING: It is a single centre prospective study carried out in a tertiary care centre at Pediatric cardiac intensive care unit. PATIENTS: All patients with the cyanotic congenital heart disease with increase pulmonary blood flow, weighing less than 5 kg and undergoing congenital heart repair during the study period were included in the study...
June 2018: Clinical Nutrition ESPEN
https://www.readbyqxmd.com/read/29778861/multicenter-randomized-controlled-crossover-trial-comparing-hemodynamic-optimization-against-echocardiographic-optimization-of-av-and-vv-delay-of-cardiac-resynchronization-therapy-the-bravo-trial
#3
Zachary I Whinnett, S M Afzal Sohaib, Mark Mason, Edward Duncan, Mark Tanner, David Lefroy, Mohamed Al-Obaidi, Sue Ellery, Francisco Leyva-Leon, Tim Betts, Mark Dayer, Paul Foley, Jon Swinburn, Martin Thomas, Raj Khiani, Tom Wong, Zaheer Yousef, Dominic Rogers, Paul R Kalra, Vignesh Dhileepan, Katherine March, James Howard, Andreas Kyriacou, Jamil Mayet, Prapa Kanagaratnam, Michael Frenneaux, Alun D Hughes, Darrel P Francis
OBJECTIVES: BRAVO (British Randomized Controlled Trial of AV and VV Optimization) is a multicenter, randomized, crossover, noninferiority trial comparing echocardiographic optimization of atrioventricular (AV) and interventricular delay with a noninvasive blood pressure method. BACKGROUND: Cardiac resynchronization therapy including AV delay optimization confers clinical benefit, but the optimization requires time and expertise to perform. METHODS: This study randomized patients to echocardiographic optimization or hemodynamic optimization using multiple-replicate beat-by-beat noninvasive blood pressure at baseline; after 6 months, participants were crossed over to the other optimization arm of the trial...
May 11, 2018: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/29772332/outcomes-following-transaxillary-approach-to-cervical-and-first-rib-resection-for-neurogenic-thoracic-outlet-syndrome
#4
Arjun Jayaraj, Audra A Duncan, Manju Kalra, Thomas C Bower, Peter Gloviczki
OBJECTIVE: Cervical rib can often be symptomatic causing neurogenic thoracic outlet syndrome (nTOS). Surgical treatment involves rib resection through a supraclavicular, transaxillary or combined approach. We review outcomes of different approaches and describe our technique of transaxillary resection through a video. METHODS: Single center retrospective review of peri-operative and short-term outcomes in subjects undergoing cervical rib resection for nTOS between 1994 and 2013...
May 14, 2018: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/29766945/proposed-solution-for-dorsal-internal-carotid-artery-aneurysms-suggestion-of-a-novel-new-clip-design
#5
Ashish Aggarwal, Manarshhjot Singh, Parveen Kalra
Dorsal internal carotid artery (ICA) aneurysms are notorious for their high morbidity and mortality. They have an extremely fragile wall and have a high chance of rupture and clip slippage during the intraoperative and postoperative period. Strategies proposed to mitigate these problems encompass including part of the normal ICA wall in addition to neck of aneurysm in clip blades, as well as the use of encircling materials (silicon, cellulose, Weck's clip) over a clip. The Achilles' heel of the problem is to take an appropriate thickness of the normal ICA in clip blades...
May 2018: Neurology India
https://www.readbyqxmd.com/read/29752222/the-berlin-declaration-a-call-to-improve-early-actions-related-to-type-2-diabetes-why-is-primary-care-important
#6
REVIEW
Kamlesh Khunti, James R Gavin, Andrew J M Boulton, Rick Blickstead, Margaret McGill, Antonio Ceriello, Itamar Raz, Shaukat Sadikot, David A Wood, Xavier Cos, Sanjay Kalra, Ashok Kumar Das, Cutberto Espinosa López
Diabetes is epidemic worldwide and places a huge burden on healthcare systems. The majority of the cost of type 2 diabetes (T2D) is related to hospitalization and the management of complications, and these also have a negative impact on the individual's quality of life. The Berlin Declaration is a global call for early action for the identification of high risk individuals, prevention of T2D and the prevention of complications in those with T2D, through prevention, early detection, early control and early access to the right multidisciplinary interventions...
May 8, 2018: Primary Care Diabetes
https://www.readbyqxmd.com/read/29748568/carf-enrichment-promotes-epithelial-mesenchymal-transition-via-wnt-%C3%AE-catenin-signaling-its-clinical-relevance-and-potential-as-a-therapeutic-target
#7
Rajkumar S Kalra, Anupama Chaudhary, A-Rum Yoon, Priyanshu Bhargava, Amr Omar, Sukant Garg, Chae-Ok Yun, Sunil C Kaul, Renu Wadhwa
CARF (Collaborator of ARF)/CDKN2AIP was discovered as a novel ARF-binding protein. It has been established as an essential cell survival, p53-, and cell proliferation-regulatory protein. Although a moderate upregulation of CARF caused growth arrest and senescence, its excessively enriched levels were shown to facilitate aggressive proliferation and malignant transformation of cancer cells. Here, we examined the relevance of CARF levels in clinical tumors and found its amplification (both at gene and transcript levels) in a variety of invasive and metastatic malignancies...
May 11, 2018: Oncogenesis
https://www.readbyqxmd.com/read/29745979/trends-etiologies-and-predictors-of-90-day-readmission-after-percutaneous-ventricular-assist-device-implantation-a-national-population-based-cohort-study
#8
Hafeez Ul Hassan Virk, Byomesh Tripathi, Shuchita Gupta, Akanksha Agrawal, Sandeep Dayanand, Faisal Inayat, Chayakrit Krittanawong, Ali Raza Ghani, Mohammad Nour Zabad, Parasuram Melarcode Krishnamoorthy, Aman Amanullah, Gregg Pressman, Christian Witzke, Sean Janzer, Jon George, Sanjog Kalra, Vincent Figueredo
Percutaneous ventricular assist devices (pVADs) are indicated to provide hemodynamic support in high-risk percutaneous interventions and cardiogenic shock. However, there is a paucity of published data regarding the etiologies and predictors of 90-day readmissions following pVAD use. We studied the data from the US Nationwide Readmissions Database (NRD) for the years 2013 and 2014. Patients with a primary discharge diagnosis of pVAD use were collected by searching the database for International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM) procedural code 37...
May 10, 2018: Clinical Cardiology
https://www.readbyqxmd.com/read/29744821/thoughts-words-action-the-alma-ata-declaration-to-diabetes-care-transformation
#9
EDITORIAL
Sanjay Kalra, Zhanay A Akanov, Alex Y Pleshkova
The International Conference on Primary Health Care, held at Alma-Ata, present-day Kazakhstan, in September 1978, was a landmark in global health care. The Declaration of Alma-Ata that was adopted at that conference successfully refocused attention and energy on primary health care. In a similar manner, the United Nations resolution of 2006 highlighted the dangers of the diabetes pandemic. The underlying philosophy of the Declaration of Alma-Ata is assessed in this editorial, to determine whether it remains relevant for modern and future diabetes care...
May 9, 2018: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://www.readbyqxmd.com/read/29743996/emerging-transcatheter-options-for-tricuspid-regurgitation
#10
REVIEW
Ankur Kalra, Angad S Uberoi, Azeem Latib, Sahil Khera, Stephen H Little, Deepak L Bhatt, Michael J Reardon, Neal S Kleiman, Colin M Barker
Tricuspid regurgitation (TR) presents as either primary valve pathology or secondary to pulmonary or left-sided heart disease. Severe TR portends a worse prognosis independent of age, right ventricular size and function, severe left ventricular dysfunction, and increased pulmonary arterial pressures. Surgical treatment for TR has mostly been limited to patients undergoing mitral valve repair since those at high surgical risk are not candidates for traditional TR surgery. For these patients, minimally invasive techniques could be of great benefit, yet these techniques have been slow to develop because of the various anatomic and physiological aspects of the tricuspid valve apparatus...
July 2017: Methodist DeBakey Cardiovascular Journal
https://www.readbyqxmd.com/read/29737542/anticancer-activity-of-dihydropyrazolo-1-5-c-quinazolines-against-rat-c6-glioma-cells-via-inhibition-of-topoisomerase-ii
#11
Gagandeep Kaur, Ravi P Cholia, Gaurav Joshi, Suyog M Amrutkar, Sourav Kalra, Anil K Mantha, Uttam C Banerjee, Raj Kumar
The design and synthesis of dihydropyrazolo[1,5-c]quinazolines (1a-h) as human topoisomerase II (TopoII) catalytic inhibitors are reported. The compounds were investigated for their antiproliferative activity against the C6 rat glial cell line. Two compounds, 1b and 1h, were found to be potent cytotoxic agents against glioma cells and exerted selective TopoII inhibitory activity. Furthermore, the compounds induced alterations in reactive oxygen species levels as measured by DCFDA assay and were found to induce cell cycle arrest at the G1 phase at lower concentrations and profound apoptosis at higher concentrations...
May 8, 2018: Archiv der Pharmazie
https://www.readbyqxmd.com/read/29727056/a-comparison-of-ketamine-midazolam-to-propofol-for-procedural-sedation-for-lumbar-puncture-in-pediatric-oncology-by-nonanesthesiologists-a-randomized-comparative-trial
#12
Varsha Chayapathi, Manas Kalra, Anita S Bakshi, Amita Mahajan
BACKGROUND: Both ketamine-midazolam and propofol are frequently used in pediatric oncology units for procedural sedation. However, there are no prospective, randomized comparative trials (RCT) comparing the two groups when the procedure is performed by nonanesthesiologists. OBJECTIVE: To compare ketamine + midazolam (group A) and propofol (group B) as sedative agents for intrathecal chemotherapy with regard to efficacy, side effects, time to induction, time to recovery, and smoothness of recovery...
May 4, 2018: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/29724365/trends-and-cost-of-heart-transplantation-and-left-ventricular-assist-devices-impact-of-proposed-federal-cuts
#13
Nirav Patel, Rajat Kalra, Rajkumar Doshi, Navkaranbir S Bajaj, Garima Arora, Pankaj Arora
OBJECTIVES: The purpose of this study was to compare trends of use, in-hospital mortality, and annual expenditures associated with orthotopic heart transplantation (OHT) and left ventricular assist device (LVAD) implantation. In view of the changing health care landscape, we assessed the impact of federal funding cuts on Medicare and Medicaid beneficiaries seeking these procedures. BACKGROUND: Use and cost trends associated with OHT and LVAD are not well defined...
May 2018: JACC. Heart Failure
https://www.readbyqxmd.com/read/29697545/transcatheter-valvular-interventions-in-2017-some-things-old-some-things-new
#14
Hasan Rehman, Neal S Kleiman, Ankur Kalra
PURPOSE OF REVIEW: Transcatheter valvular interventions have changed the landscape of valvular therapies. We examine some studies on transcatheter valvular interventions published in the year 2017 to better understand their implications on clinical practice and future research. RECENT FINDINGS: Findings from the SURTAVI study suggest TAVR to be a reasonable option in intermediate risk patients with aortic stenosis. Recent studies indicate that valve leaflet thrombosis is associated with poor outcomes...
April 24, 2018: Current Opinion in Cardiology
https://www.readbyqxmd.com/read/29689070/fti-277-inhibits-smooth-muscle-cell-calcification-by-up-regulating-pi3k-akt-signaling-and-inhibiting-apoptosis
#15
Arvind Ponnusamy, Smeeta Sinha, Gareth D Hyde, Samantha J Borland, Rebecca F Taylor, Emma Pond, Heather J Eyre, Colette A Inkson, Andrew Gilmore, Nick Ashton, Philip A Kalra, Ann E Canfield
BACKGROUND: Vascular calcification is associated with increased cardiovascular morbidity and mortality in patients with atherosclerosis, diabetes and chronic kidney disease. However, no viable treatments for this condition have been identified. This study aimed to determine whether farnesyl transferase inhibitors (FTIs) can reduce vascular calcification and the mechanism by which this reduction occurs. RESULTS: We demonstrate that FTI-277 significantly inhibits phosphate-induced mineral deposition by vascular smooth muscle cells (VSMC) in vitro, prevents VSMC osteogenic differentiation, and increases mRNA expression of matrix Gla protein (MGP), an inhibitor of mineralization...
2018: PloS One
https://www.readbyqxmd.com/read/29685638/a-human-centered-approach-to-cv-care-infrastructure-development-in-uganda
#16
Christopher T Longenecker, Ankur Kalra, Emmy Okello, Peter Lwabi, John O Omagino, Cissy Kityo, Moses R Kamya, Allison R Webel, Daniel I Simon, Robert A Salata, Marco A Costa
In this case study, we describe an ongoing approach to develop sustainable acute and chronic cardiovascular care infrastructure in Uganda that involves patient and provider participation. Leveraging strong infrastructure for HIV/AIDS care delivery, University Hospitals Harrington Heart and Vascular Institute and Case Western Reserve University have partnered with U.S. and Ugandan collaborators to improve cardiovascular capabilities. The collaboration has solicited innovative solutions from patients and providers focusing on education and advanced training, penicillin supply, diagnostic strategy (e...
April 20, 2018: Global Heart
https://www.readbyqxmd.com/read/29685508/superior-mesenteric-artery-stenting-using-embolic-protection-device-for-treatment-of-acute-or-chronic-mesenteric-ischemia
#17
Bernardo C Mendes, Gustavo S Oderich, Tiziano Tallarita, Karina S Kanamori, Manju Kalra, Randall R DeMartino, Fahad Shuja, Jill K Johnstone
OBJECTIVE: The objective of the study was to report the feasibility and results of superior mesenteric artery (SMA) stenting using embolic protection devices (EPDs) to treat acute mesenteric ischemia (AMI) and chronic mesenteric ischemia (CMI). METHODS: A retrospective review was conducted of consecutive patients who underwent SMA stenting with EPDs from 2007 to 2016. EPDs were used selectively in patients with occlusions, severe calcification, or acute thrombus...
April 20, 2018: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/29674011/endovascular-transjugular-occlusion-of-congenital-intrahepatic-portosystemic-venous-shunt-using-simultaneous-fluoroscopy-and-transabdominal-ultrasound-guidance-report-of-2-cases
#18
Ujjwal Gorsi, Naveen Kalra, Pankaj Gupta, Karthik Rayasam, Babu Ram Thapa, Hemant Bhagat, Niranjan Khandelwal
Congenital intrahepatic portosystemic venous shunts (CIPVS) are rare anomalies that can be detected before birth or in early infancy or later in life. Symptomatic shunts are treated as they carry high risk of complications like hepatic encephalopathy. Various treatment options include surgery, endovascular embolization, and percutaneous closure devices. We treated 2 infants with CIPVS successfully by endovascular embolization of the shunt using vascular plug through transjugular route. Transabdominal ultrasound guidance in addition to fluoroscopy was used at the time of vascular plug placement...
March 20, 2018: Current Problems in Diagnostic Radiology
https://www.readbyqxmd.com/read/29671218/neuroimaging-of-meckel-s-cave-in-normal-and-disease-conditions
#19
REVIEW
Ajay Malhotra, Long Tu, Vivek B Kalra, Xiao Wu, Ali Mian, Rajiv Mangla, Elias Michaelides, Pina Sanelli, Dheeraj Gandhi
Meckel's cave is a dural recess in the posteromedial portion of the middle cranial fossa that acts as a conduit for the trigeminal nerve between the prepontine cistern and the cavernous sinus, and houses the Gasserian ganglion and proximal rootlets of the trigeminal nerve. It serves as a major pathway in perineural spread of pathologies such as head and neck neoplasms, automatically upstaging tumours, and is a key structure to assess in cases of trigeminal neuralgia. The purpose of this pictorial review is threefold: (1) to review the normal anatomy of Meckel's cave; (2) to describe imaging findings that identify disease involving Meckel's cave; (3) to present case examples of trigeminal and non-trigeminal processes affecting Meckel's cave...
April 18, 2018: Insights Into Imaging
https://www.readbyqxmd.com/read/29663916/a-bag-of-marbles-a-fascinating-compound-odontoma-of-the-maxilla
#20
Aneesh Kalra, Evelyn C Sheehy, Joanna Johnson, Fraser McDonald
Odontomas are the most common odontogenic tumors, typically diagnosed during the first two decades of life. 1 The purpose of this paper was to report an interesting case of an eight-year-old Caucasian boy who presented with an asymptomatic, progressive, firm swelling of the right maxilla with no eruption of the permanent maxillary right lateral incisor. Radiographic investigation revealed a mixed radiolucent and radiopaque lesion measuring 28 by 24 by 17 mm with a corticated border causing expansion and thinning of the buccal cortical plate...
March 15, 2018: Pediatric Dentistry
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