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https://www.readbyqxmd.com/read/28426845/her2-specific-chimeric-antigen-receptor-modified-virus-specific-t-cells-for-progressive-glioblastoma-a-phase-1-dose-escalation-trial
#1
Nabil Ahmed, Vita Brawley, Meenakshi Hegde, Kevin Bielamowicz, Mamta Kalra, Daniel Landi, Catherine Robertson, Tara L Gray, Oumar Diouf, Amanda Wakefield, Alexia Ghazi, Claudia Gerken, Zhongzhen Yi, Aidin Ashoori, Meng-Fen Wu, Hao Liu, Cliona Rooney, Gianpietro Dotti, Adrian Gee, Jack Su, Yvonne Kew, David Baskin, Yi Jonathan Zhang, Pamela New, Bambi Grilley, Milica Stojakovic, John Hicks, Suzanne Z Powell, Malcolm K Brenner, Helen E Heslop, Robert Grossman, Winfried S Wels, Stephen Gottschalk
Importance: Glioblastoma is an incurable tumor, and the therapeutic options for patients are limited. Objective: To determine whether the systemic administration of HER2-specific chimeric antigen receptor (CAR)-modified virus-specific T cells (VSTs) is safe and whether these cells have antiglioblastoma activity. Design, Setting, and Participants: In this open-label phase 1 dose-escalation study conducted at Baylor College of Medicine, Houston Methodist Hospital, and Texas Children's Hospital, patients with progressive HER2-positive glioblastoma were enrolled between July 25, 2011, and April 21, 2014...
April 20, 2017: JAMA Oncology
https://www.readbyqxmd.com/read/28423825/hemic-project-design-of-a-clinical-information-modelling-tool-based-on-iso13972-technical-specification
#2
Alberto Moreno-Conde, Francisco Sanchez-Laguna, Bidatzi Marin-Bastida, Antonio Romero-Tabares, Eva Martin-Sánchez, Dipak Kalra, Carlos Luis Parra-Calderón
The Andalusian Health Service is the public healthcare provider for 8.302.923 inhabitants in the South Spain. This organization coordinates primary and specialized care with an IT infrastructure composed by multiple Electronic Health Record Systems. According to the large volume of healthcare professionals involved, there is a need for providing a consistent management of information through multiple locations and systems. The HEMIC project aims to address this need developing and validating a methodology based on a software tool for standardizing information contained within EHR systems...
2017: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/28423747/establishment-of-requirements-and-methodology-for-the-development-and-implementation-of-greymatters-a-memory-clinic-information-system
#3
Archana Tapuria, Matt Evans, Vasa Curcin, Tony Austin, Nathan Lea, Dipak Kalra
INTRODUCTION: The aim of the paper is to establish the requirements and methodology for the development process of GreyMatters, a memory clinic system, outlining the conceptual, practical, technical and ethical challenges, and the experiences of capturing clinical and research oriented data along with the implementation of the system. METHODS: The methodology for development of the information system involved phases of requirements gathering, modeling and prototype creation, and 'bench testing' the prototype with experts...
2017: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/28420935/prevention-of-hypoglycaemia-the-asap-anticipate-suspect-act-prevent-strategy
#4
Sanjay Kalra, Yashdeep Gupta
This article describes a simple framework to prevent hypoglycaemia. Four strategies of prevention are detailed, which correspond to four levels of prevention (primordial, primary, secondary and tertiary). This framework, given the mnemonic ASAP (As Soon As Possible) includes action to Anticipate and Avoid, and Suspect and Screen hypoglycaemia. It also enjoins us to Act and Assist persons with hypoglycaemia in a timely manner, while working to Prevent and Protect them by using safer glucose lowering drugs and insulins...
April 2017: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/28420934/preconception-management-of-thyroid-disorders
#5
Bharti Kalra, Yashdeep Gupta, Sanjay Kalra
Thyroid function is closely interlinked with pregnancy. Maternal and foetal outcomes can be improved if optimal thyroid function is achieved, and maintained prior to conception. This needs a systematic approach which includes rational screening, appropriate management, and pragmatic counseling. This review describes pre-conception management of thyroid disorders, and completes an earlier article on preconception management of other endocrine diseases.
April 2017: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/28417301/overview-of-coronary-heart-disease-risk-initiatives-in-south-asia
#6
REVIEW
Ankur Kalra, Deepak L Bhatt, Sanjay Rajagopalan, Kunal Suri, Sundeep Mishra, Romaina Iqbal, Salim S Virani
PURPOSE OF REVIEW: Cardiovascular disease (CVD) is now the leading cause of morbidity and mortality worldwide. Industrialization and economic growth have led to an unprecedented increment in the burden of CVD and their risk factors in less industrialized regions of the world. While there are abundant data on CVD and their risk factors from longitudinal cohort studies done in the West, good-quality data from South Asia are lacking. RECENT FINDINGS: Several multi-institutional, observational, prospective registries, and epidemiologic cohorts in South Asia have been established to systematically evaluate the burden of CVD and their risk factors...
June 2017: Current Atherosclerosis Reports
https://www.readbyqxmd.com/read/28416929/role-of-coma-acidosis-malaria-score-in-patients-with-severe-malaria-among-indian-population-a-tertiary-care-center-experience
#7
Hari Krishan Aggarwal, Deepak Jain, Avinash Rao, Rajinish Kalra
OBJECTIVE: Malaria is a prime public health threat in developing countries like India. There is an unmet need of a simplified methodology for the purpose of triage and provision of intensive care to the severely infected patients in these areas. MATERIALS AND METHODS: We did a prospective study in patients (n=60) admitted with severe malaria in a single tertiary care center in the state of Haryana, India. We assessed the role of coma acidosis malaria (CAM) score in these patients when predicting mortality and morbidity events...
February 2017: Eurasian Journal of Medicine
https://www.readbyqxmd.com/read/28400813/adenyl-cyclase-activator-forskolin-protects-against-huntington-s-disease-like-neurodegenerative-disorders
#8
Sidharth Mehan, Shaba Parveen, Sanjeev Kalra
Long term suppression of succinate dehydrogenase by selective inhibitor 3-nitropropionic acid has been used in rodents to model Huntington's disease where mitochondrial dysfunction and oxidative damages are primary pathological hallmarks for neuronal damage. Improvements in learning and memory abilities, recovery of energy levels, and reduction of excitotoxicity damage can be achieved through activation of Adenyl cyclase enzyme by a specific phytochemical forskolin. In this study, intraperitoneal administration of 10 mg/kg 3-nitropropionic acid for 15 days in rats notably reduced body weight, worsened motor cocordination (grip strength, beam crossing task, locomotor activity), resulted in learning and memory deficits, greatly increased acetylcholinesterase, lactate dehydrogenase, nitrite, and malondialdehyde levels, obviously decreased adenosine triphosphate, succinate dehydrogenase, superoxide dismutase, catalase, and reduced glutathione levels in the striatum, cortex and hippocampus...
February 2017: Neural Regeneration Research
https://www.readbyqxmd.com/read/28385700/establishing-a-contemporary-training-curriculum-for-the-next-generation-of-interventional-cardiology-fellows
#9
EDITORIAL
Harsh B Golwala, Ankur Kalra, David P Faxon
No abstract text is available yet for this article.
April 2017: Circulation. Cardiovascular Interventions
https://www.readbyqxmd.com/read/28384940/a-rare-case-of-successfully-treated-coombs-negative-immune-haemolytic-anaemia-in-pregnancy
#10
Pradip Kumar Saha, Japleen Kaur, Rashmi Bagga, Jaswinder Kaur Kalra, Arihant Jain
Immune haemolytic anaemia in pregnancy, although rare, but it can be life threatening. Severe anaemia with jaundice, unresponsive to blood transfusion can clinch the diagnosis of immune haemolytic anaemia. Our patient was a 27-year-old second gravida, with all the above features, but there was diagnostic challenge as her Coombs test was negative. A high index of suspicion and rapid response to glucocorticoids, pointed towards the diagnosis. Thereafter, the course of pregnancy and postpartum period was uneventful...
February 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28382771/patterns-of-cultural-consensus-and-intracultural-diversity-in-ghanaian-complementary-feeding-practices
#11
Nikhila Kalra, Gretel Pelto, Charlotte Tawiah, Stephanie Zobrist, Peiman Milani, Grace Manu, Amos Laar, Megan Parker
Designing effective interventions to improve infant and young child (IYC) feeding requires knowledge about determinants of current practices, including cultural factors. Current approaches to obtaining and using research on culture tend to assume cultural homogeneity within a population. The purpose of this study was to examine the extent of cultural consensus (homogeneity) in communities where interventions to improve IYC feeding practices are needed to address undernutrition during the period of complementary feeding...
April 6, 2017: Maternal & Child Nutrition
https://www.readbyqxmd.com/read/28371854/the-effect-of-revascularization-in-patients-with-anatomically-significant-atherosclerotic-renovascular-disease-presenting-with-high-risk-clinical-features
#12
Diana Vassallo, James Ritchie, Darren Green, Constantina Chrysochou, PhilipA Kalra
Background.: Patients with atherosclerotic renovascular disease (ARVD) and high-risk clinical presentations have largely been excluded from randomized controlled trials comparing renal revascularization and optimal medical therapy. Here, we explore the effect of revascularization on death, progression to end-stage kidney disease (ESKD) and cardiovascular events (CVE) in a highly selected cohort of patients with ARVD. Methods.: All patients with a radiological diagnosis of ARVD referred to our tertiary centre have been recruited into a single-centre cohort study between 1986 and 2014...
March 23, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/28368271/consensus-statement-of-the-indian-academy-of-pediatrics-on-evaluation-and-management-of-attention-deficit-hyperactivity-disorder
#13
Samir Dalwai, Jeeson Unni, Veena Kalra, Pratibha Singhi, Leena Shrivastava, M K C Nair
JUSTIFICATION: Attention-Deficit/Hyperactivity Disorder (ADHD) is a highly prevalent in children worldwide. Management of ADHD requires a systematic, multidisciplinary approach and thereby, evidence-based, standardized national guidelines are essential. PROCESS: A meeting for formulation of national consensus guidelines on neurodevelopmental disorders was organized by Indian Academy of Pediatrics in Mumbai, on 18th and 19th December, 2015. The invited experts included Pediatricians, Developmental Pediatricians, Pediatric Neurologists, Psychiatrists, Remedial Educators and Clinical Psychologists...
March 29, 2017: Indian Pediatrics
https://www.readbyqxmd.com/read/28367495/long-term-outcomes-of-palliative-colonic-stenting-versus-emergency-surgery-for-acute-proximal-malignant-colonic-obstruction-a-multicenter-trial
#14
Ali Siddiqui, Natalie Cosgrove, Linda H Yan, Daniel Brandt, Raymond Janowski, Ankush Kalra, Tingting Zhan, Todd H Baron, Allesandro Repici, Linda Jo Taylor, Douglas G Adler
Background and study aims Long-term data are limited regarding clinical outcomes of self-expanding metal stents as an alternative for surgery in the treatment of acute proximal MBO. The aim of this study was to compare the long-term outcomes of stenting to surgery for palliation in patients with incurable obstructive CRC for lesions proximal to the splenic flexure. Patients and methods Retrospective multicenter cohort study of obstructing proximal CRC patients with who underwent insertion of a SEMS (n = 69) or surgery (n = 36) from 1999 to 2014...
April 2017: Endoscopy International Open
https://www.readbyqxmd.com/read/28361822/comparative-study-of-clozapine-versus-risperidone-in-treatment-naive-first-episode-schizophrenia-a-pilot-study
#15
Sukhtej Sahni, B S Chavan, Ajeet Sidana, Priyanka Kalra, Gurjit Kaur
BACKGROUND & OBJECTIVES: Clozapine may be more useful in treatment-naive patients with first-episode schizophrenia for better symptoms control and improving quality of life. The current study was carried out to compare the efficacy and tolerability of clozapine versus risperidone in treatment-naive, first-episode patients of schizophrenia. METHODS: This was a comparative, open-label, six months prospective study of treatment-naive, first-episode patients with schizophrenia between the age group of 18 and 40 yr diagnosed as per the International Classification of Diseases-10 (ICD-10) criteria...
November 2016: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/28344754/role-of-angiotensin-converting-enzyme-and-angiotensinogen-gene-polymorphisms-in-angiotensin-converting-enzyme-inhibitor-mediated-antiproteinuric-action-in-type-2-diabetic-nephropathy-patients
#16
Neerja Aggarwal, Pawan Kumar Kare, Parul Varshney, Om Prakash Kalra, Sri Venkata Madhu, Basu Dev Banerjee, Anil Yadav, Alpana Raizada, Ashok Kumar Tripathi
AIM: To investigate the role of genetic variants of angiotensin converting enzyme (ACE) and angiotensinogen (AGT) genes in the antiproteinuric efficacy of ACE inhibitor therapy in diabetic nephropathy (DN) patients. METHODS: In the present study, 270 type 2 diabetes mellitus patients with nephropathy were enrolled and treated with ACE inhibitor (ramipril) and followed at 6 mo for renal function and albumin excretion by estimating serum creatinine, end stage renal disease, and albumin/creatinine ratio (ACR) in urine...
March 15, 2017: World Journal of Diabetes
https://www.readbyqxmd.com/read/28336414/ccr6-th-cells-in-the-cerebrospinal-fluid-of-persons-with-multiple-sclerosis-are-dominated-by-pathogenic-non-classic-th1-cells-and-gm-csf-only-secreting-th-cells
#17
S M Restorick, L Durant, S Kalra, G Hassan-Smith, E Rathbone, M R Douglas, S J Curnow
Considerable attention has been given to CCR6(+) IL-17-secreting CD4(+) T cells (Th17) in the pathology of a number of autoimmune diseases including multiple sclerosis (MS). However, other Th subsets also play important pathogenic roles, including those that secrete IFNγ and GM-CSF. CCR6 expression by Th17 cells allows their migration across the choroid plexus into the cerebrospinal fluid (CSF), where they are involved in the early phase of experimental autoimmune encephalomyelitis (EAE), and in MS these cells are elevated in the CSF during relapses and contain high frequencies of autoreactive cells...
March 20, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/28331253/content-of-food-advertising-for-young-adolescents-on-television
#18
Setu Gupta, Swati Kalra, Jaya Shankar Kaushik, Piyush Gupta
BACKGROUND: Food related advertisements on television may have a major influence on the dietary habits and obesity among young adolescents. OBJECTIVE: To evaluate the frequency and typology of food advertisements on most popular television channels, watched by school-going young adolescents in Delhi. METHODOLOGY: Biphasic study to (a) identify the three television channels most frequently watched by administering a questionnaire to 400 school going young adolescents; and (b) view each of these channels for 2 hours per day for 6 days each, and observe the content of advertisements related to foods, beverages, and food outlets...
January 2017: Indian Journal of Community Medicine
https://www.readbyqxmd.com/read/28325543/consensus-recommendations-on-exploring-effective-solutions-for-the-rising-cost-of-diabetes
#19
REVIEW
Shaukat M Sadikot, Ashok Kumar Das, John Wilding, Ali Siyan, Abdul Hamid Zargar, Banshi Saboo, S R Aravind, Bhavana Sosale, Sanjay Kalra, G Vijayakumar, K K Manojan, Anuj Maheshwari, Jayant K Panda, Samar Banerjee, Rajeev Chawla, Sambu Potty Vasudevan, O S Syam Sundar, Jothydev Kesavadev
Diabetes remains asymptomatic for a long period of time and its real burden gets noticed only once the complications set in. The number of individuals affected with the disease is also on the rise and more so in the low income countries. This scenario calls for urgent precautionary measures that need to be undertaken to equip ourselves to fight against this chronic disease. Individuals with financial constraints cannot afford to access even the basic treatment facilities and thus stands the most burdened. The International Diabetes Federation calls for 'Eyes on Diabetes' for the society to focus on early screening and early intervention...
March 7, 2017: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/28304008/contraception-in-women-with-diabetes
#20
Bharti Kalra, Sanjay Kalra
This brief article covers the diabetes related aspects of contraception in women. It classifies various methods of contraception and describes how presence of diabetes influences their use. The article lists the high risk conditions in diabetes which may discourage use of combined hormonal contraceptives. It discusses the relation of glycaemic control and medical termination of pregnancy (MTP), and calls for universal provision of contraceptive services to all women with diabetes.
March 2017: JPMA. the Journal of the Pakistan Medical Association
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