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https://www.readbyqxmd.com/read/27923094/alienated
#1
Ankur Kalra, Kunal Suri
No abstract text is available yet for this article.
December 6, 2016: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/27919393/business-analysis-for-a-sustainable-multi-stakeholder-ecosystem-for-leveraging-the-electronic-health-records-for-clinical-research-ehr4cr-platform-in-europe
#2
Danielle Dupont, Ariel Beresniak, Mats Sundgren, Andreas Schmidt, John Ainsworth, Pascal Coorevits, Dipak Kalra, Marc Dewispelaere, Georges De Moor
INTRODUCTION: The Electronic Health Records for Clinical Research (EHR4CR) technological platform has been developed to enable the trustworthy reuse of hospital electronic health records data for clinical research. The EHR4CR platform can enhance and speed up clinical research scenarios: protocol feasibility assessment, patient identification for recruitment in clinical trials, and clinical data exchange, including for reporting serious adverse events. Our objective was to seed a multi-stakeholder ecosystem to enable the scalable exploitation of the EHR4CR platform in Europe, and to assess its economic sustainability...
January 2017: International Journal of Medical Informatics
https://www.readbyqxmd.com/read/27913575/lowest-glucose-variability-and-hypoglycemia-are-observed-with-the-combination-of-a-glp-1-receptor-agonist-and-basal-insulin-variation-study
#3
Harpreet S Bajaj, Karri Venn, Chenglin Ye, Avril Patrick, Shivani Kalra, Hasnain Khandwala, Nadeem Aslam, David Twum-Barima, Ronnie Aronson
OBJECTIVE: There is a dearth of published literature comparing glucose variability (GV) between different insulin regimens in type 2 diabetes. This cohort study compares GV using continuous glucose monitoring (CGM) in patients with well-controlled type 2 diabetes using four common insulin regimens: basal insulin + oral drugs (BO), basal insulin + glucagon-like peptide 1 receptor agonist (GLP-1 RA) (BGLP), premixed insulin (PM), and basal-bolus insulin (BB). RESEARCH DESIGN AND METHODS: Consecutive patients from three endocrinology clinics who met study criteria-type 2 diabetes, age 18 to 80 years, BMI ≤ 45 kg/m(2), stable insulin regimen for a minimum of 6 months, and stable A1C value ≤7...
December 2, 2016: Diabetes Care
https://www.readbyqxmd.com/read/27911224/letter-to-the-editor-screening-via-ct-angiogram-and-cervical-spine-fractures
#4
Xiao Wu, David Durand, Vivek B Kalra, Sowmya Mahalingam, Ajay Malhotra
No abstract text is available yet for this article.
December 2, 2016: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/27909567/ovarian-reserve-may-be-compromised-after-adnexal-surgery-are-we-sufficiently-fertility-focused-in-our-surgical-training
#5
G S Kalra, S Campbell, G Nargund
There is a general trend towards delay in childbearing age amongst women. The ovarian reserve clearly falls with increasing age and the impact is greater with advancing age, particularly from late 30s. Presence of other risk factors can increase the risk of subfertility. A large number of women are exposed to pelvic surgery for various reasons, both elective and emergency. There is evidence that some of the pelvic surgery performed around ovaries and tubes has a negative impact on the ovarian reserve and in turn may cause a decline in woman's ability to conceive...
June 27, 2016: Facts, Views & Vision in ObGyn
https://www.readbyqxmd.com/read/27906641/time-to-cooling-is-associated-with-resuscitation-outcomes
#6
Robert B Schock, Andreas Janata, W Frank Peacock, Nathan S Deal, Sarathi Kalra, Fritz Sterz
Our purpose was to analyze evidence related to timing of cooling from studies of targeted temperature management (TTM) after return of spontaneous circulation (ROSC) after cardiac arrest and to recommend directions for future therapy optimization. We conducted a preliminary review of studies of both animals and patients treated with post-ROSC TTM and hypothesized that a more rapid cooling strategy in the absence of volume-adding cold infusions would provide improved outcomes in comparison with slower cooling...
December 2016: Therapeutic Hypothermia and Temperature Management
https://www.readbyqxmd.com/read/27886875/the-role-of-a-miniopen-thoracoscopic-assisted-approach-in-the-management-of-burst-fractures-involving-the-thoracolumbar-junction
#7
REVIEW
Ricky Raj S Kalra, Meic H Schmidt
Thoracoscopic spinal surgery is a minimally invasive open endoscopic approach to the anterior thoracolumbar spine for decompression and stabilization. It offers an alternative to open thoracotomy for thoracolumbar burst fractures, anterior spinal cord decompression, and spinal reconstruction with interbody and anterolateral plate instrumentation for restoration of biomechanical stability and alignment. Posterior instrumentation may not sufficiently stabilize a significantly disrupted anterior load-bearing spinal column, and the high access morbidity of open procedures is of significant concern...
January 2017: Neurosurgery Clinics of North America
https://www.readbyqxmd.com/read/27883312/time-course-analysis-of-gene-expression-during-the-saccharomyces-cerevisiae-hypoxic-response
#8
Nasrine Bendjilali, Samuel MacLeon, Gurmannat Kalra, Stephen D Willis, A K M Nawshad Hossian, Erica Avery, Olivia Wojtowicz, Mark J Hickman
Many cells experience hypoxia, or low oxygen, and respond by dramatically altering gene expression. In the yeast S. cerevisiae, genes that respond are required for many oxygen-dependent cellular processes, such as respiration, biosynthesis and redox regulation. To more fully characterize the global response to hypoxia, we exposed yeast to hypoxic conditions, extracted RNA at different times and performed RNA-seq analysis. Time-course statistical analysis revealed hundreds of genes that changed expression by up to 550-fold...
November 9, 2016: G3: Genes—Genomes—Genetics
https://www.readbyqxmd.com/read/27873474/spectrum-of-gallbladder-malignancies-on-fine-needle-aspiration-cytology-5-years-retrospective-single-institutional-study-with-emphasis-on-uncommon-variants
#9
Rajesh Kumar, Radhika Srinivasan, Nalini Gupta, Pranab Dey, Arvind Rajwanshi, Raje Nijhawan, Anupam Lal, Naveen Kalra
BACKGROUND: Ultrasound-guided fine-needle aspiration cytology (FNAC) is the standard modality for diagnosis of gallbladder malignant neoplasms. Adenocarcinoma is the most common malignancy; however, other types may also be encountered. The aim of this study was to perform a retrospective analysis of gallbladder malignancies diagnosed on FNAC in the last 5 years to document the cytomorphological spectrum and the variations thereof. METHODS: The records of the Department of Cytology, PGIMER were searched from July 2010 to June 2015 and all cases of gallbladder malignancies were analyzed in detail for cytomorphological characteristics...
November 22, 2016: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/27871721/roles-of-human-epididymis-protein-4-carbohydrate-antigen-125-inhibin-b-and-anti-m%C3%A3-llerian-hormone-in-the-differential-diagnosis-and-follow-up-of-ovarian-granulosa-cell-tumors
#10
Ulla-Maija Haltia, Marianne Hallamaa, Johanna Tapper, Johanna Hynninen, Henrik Alfthan, Bhanu Kalra, Olli Ritvos, Markku Heikinheimo, Leila Unkila-Kallio, Antti Perheentupa, Anniina Färkkilä
OBJECTIVE: Evaluation of circulating tumor markers in ovarian cancer is crucial for optimal patient care. The goal of this study was to verify the most accurate circulating tumor markers for the diagnosis and follow-up of adult-type granulosa cell tumors (AGCTs). METHODS: The levels of circulating human epididymis protein 4 (HE4) and carbohydrate antigen 125 (CA125), together with AGCT markers inhibin B and anti-Müllerian hormone (AMH), were measured in 135 samples from AGCT patients, 37 epithelial ovarian carcinoma (EOC) patients, and 40 endometrioma (ENDO) patients...
November 18, 2016: Gynecologic Oncology
https://www.readbyqxmd.com/read/27870633/dsa-of-perimesencephalic-hemorrhage
#11
Ajay Malhotra, Xiao Wu, David Durand, Vivek B Kalra, Howard P Forman
No abstract text is available yet for this article.
December 2016: Radiology
https://www.readbyqxmd.com/read/27868075/novel-mutation-of-interferon-%C3%AE-receptor-1-gene-presenting-as-early-life-mycobacterial-bronchial-disease
#12
Maria J Gutierrez, Neelu Kalra, Alexandra Horwitz, Gustavo Nino
Mendelian susceptibility to mycobacterial diseases (MSMD) are a spectrum of inherited disorders characterized by localized or disseminated infections caused by atypical mycobacteria. Interferon-γ receptor 1 (IFNGR1) deficiency was the first identified genetic disorder recognized as MSMD. Mutations in the genes encoding IFNGR1 can be recessive or dominant and cause complete or partial receptor deficiency. We present the case of a 2½-year-old boy with a history of recurrent wheezing, diagnosed with endobronchial mycobacterial infection...
October 2016: Journal of Investigative Medicine High Impact Case Reports
https://www.readbyqxmd.com/read/27867903/incretin-learning-and-excellence-academy-for-diabetes-ilead
#13
Sarita Bajaj, Subhankar Chowdhury, Ashok Kumar Das, Sanjay Kalra, Rakesh Kumar Sahay
No abstract text is available yet for this article.
November 2016: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27867893/forum-for-injection-technique-2-0-addendum-1-insulin-use-in-indoor-settings
#14
Sanjay Kalra, Hemraj B Chandalia, Manoj Chawla, Nita Munshi, Aruna Poojary, Ami Varaiya, Prajakta Hindlekar, Mugdha Lad, Valsa Thomas, Neha Karle, A G Unnikrishnan
Insulin is a frequently used drug in the indoor setting. Comprehensive recommendations for best practice in insulin injection technique have been published by the forum for injection technique (FIT), India. This addendum focuses on insulin use in indoor settings, and complements the FIT 2.0 recommendations. It discusses insulin use and disposal in critical care and noncritical care settings. It also highlights the need to ensure continuing nursing and medical education, and frame insulin policies for such use...
November 2016: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27867874/serum-adiponectin-levels-in-gestational-diabetes-mellitus
#15
Abhijit Bhograj, K M Suryanarayana, Ashwini Nayak, N S Murthy, Mala Dharmalingam, Pramila Kalra
INTRODUCTION: Gestational diabetes mellitus (GDM) is defined as any degree of glucose intolerance with onset or first recognition during pregnancy.([1]) Pregnancy is a unique situation in which there is a physiological temporary increase in insulin resistance (IR). The mechanisms responsible for the gestational-induced IR are not completely understood. The current study was undertaken to compare adiponectin levels during 24-28 weeks period of gestation in drug-naive newly diagnosed GDM women with a cohort of normoglycemic pregnant women...
November 2016: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27867872/the-rule-of-two-thirds-in-thyroid-epidemiology
#16
EDITORIAL
Sanjay Kalra, A G Unnikrishnan, Vipin Talwar
No abstract text is available yet for this article.
November 2016: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27864668/unproven-therapies-for-diabetes-and-their-implications
#17
REVIEW
Jothydev Kesavadev, Banshi Saboo, Shaukat Sadikot, Ashok Kumar Das, Shashank Joshi, Rajeev Chawla, Hemant Thacker, Arun Shankar, Lakshmy Ramachandran, Sanjay Kalra
Diabetes is a chronic disease and is one of the leading causes of morbidity and mortality worldwide. Being an ancient disease, many individuals follow complementary and alternative medicinal (CAM) therapies for either the cure or prevention of the disease. The popularity of these practices among the general public is in no way a testimony to their safety and efficacy. Due to the possibility of undesirable interactions with conventional medicines, it is imperative that patients are asked about CAM use during patient assessment...
November 18, 2016: Advances in Therapy
https://www.readbyqxmd.com/read/27854224/can-human-pluripotent-stem-cell-derived-cardiomyocytes-advance-understanding-of-muscular-dystrophies
#18
Spandan Kalra, Federica Montanaro, Chris Denning
Muscular dystrophies (MDs) are clinically and molecularly a highly heterogeneous group of single-gene disorders that primarily affect striated muscles. Cardiac disease is present in several MDs where it is an important contributor to morbidity and mortality. Careful monitoring of cardiac issues is necessary but current management of cardiac involvement does not effectively protect from disease progression and cardiac failure. There is a critical need to gain new knowledge on the diverse molecular underpinnings of cardiac disease in MDs in order to guide cardiac treatment development and assist in reaching a clearer consensus on cardiac disease management in the clinic...
August 30, 2016: Journal of Neuromuscular Diseases
https://www.readbyqxmd.com/read/27852662/the-associations-of-blood-kidney-injury-molecule-1-and-neutrophil-gelatinase-associated-lipocalin-with-progression-from-ckd-to-esrd
#19
Helen V Alderson, James P Ritchie, Sabrina Pagano, Rachel J Middleton, Menno Pruijm, Nicolas Vuilleumier, Philip A Kalra
BACKGROUND AND OBJECTIVES: Elevated levels of urinary kidney injury molecule-1 and neutrophil gelatinase-associated lipocalin are associated with negative outcomes in CKD. Our study aimed to explore the prognostic accuracy of blood levels of kidney injury molecule-1 and neutrophil gelatinase-associated lipocalin for progression to ESRD, major adverse cardiovascular events, and death in a large cohort of adult patients with all-cause nondialysis-dependent CKD stages 3-5. We considered whether these factors improve prediction in relation to traditional biomarkers and clinical parameters...
November 16, 2016: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/27851537/1902-acute-presentation-of-plastic-bronchitis-with-h1n1-2009-co-infection
#20
Pratibha Agarwal, Melinda Lucas, Barbara Stewart, Kiran Kalra
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
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