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Peripheral pulmonary lesion

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https://www.readbyqxmd.com/read/29770135/mucosal-immunity-and-protective-efficacy-of-intranasal-inactivated-influenza-vaccine-is-improved-by-chitosan-nanoparticle-delivery-in-pigs
#1
Santosh Dhakal, Sankar Renu, Shristi Ghimire, Yashavanth Shaan Lakshmanappa, Bradley T Hogshead, Ninoshkaly Feliciano-Ruiz, Fangjia Lu, Harm HogenEsch, Steven Krakowka, Chang Won Lee, Gourapura J Renukaradhya
Annually, swine influenza A virus (SwIAV) causes severe economic loss to swine industry. Currently used inactivated SwIAV vaccines administered by intramuscular injection provide homologous protection, but limited heterologous protection against constantly evolving field viruses, attributable to the induction of inadequate levels of mucosal IgA and cellular immune responses in the respiratory tract. A novel vaccine delivery platform using mucoadhesive chitosan nanoparticles (CNPs) administered through intranasal (IN) route has the potential to elicit strong mucosal and systemic immune responses in pigs...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29732193/photodynamic-therapeutic-ablation-for-peripheral-pulmonary-malignancy-via-electromagnetic-navigation-bronchoscopy-localization-in-a-hybrid-operating-room-or-a-pioneering-study
#2
Ke-Cheng Chen, Jang-Ming Lee
Background: With the aid of electromagnetic navigation bronchoscopy (ENB), it has become possible to approach peripheral lung tumors from the airway. Meanwhile, local ablation using photodynamic therapy (PDT) has shown increasing promise in the realm of lung cancer treatment. The purpose of this study was to explore an alternative ablation method using PDT with SuperDimension ENB localization in a hybrid operating theater. Methods: Our study includes patients with primary or metastatic lung cancer who underwent PDT via ENB in the hybrid operating room (OR) of National Taiwan University Hospital between January 2016 and January 2017...
April 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29680795/monomac-syndrome-with-associated-neurological-deficits-and-longitudinally-extensive-cord-lesion
#3
Mastura Monif, Aamira Huq, Lynette Chee, Trevor Kilpatrick
We present a case of monocytopaenia and mycobacteria-related infection (MonoMac) syndrome in a 30-year-old man of Indian origin. The clinical diagnosis of GATA2 haploinsufficiency was suspected after an unusual neurological presentation on a background of myelodysplastic syndrome and childhood pulmonary tuberculosis. The patient had a longitudinally extensive spinal cord lesion and a lesion in the medulla. No obvious infective cause for the spinal cord MRI abnormality was found, and the lesions were presumed to be inflammatory in nature...
April 21, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29679545/the-impact-of-ocular-tuberculosis-on-vision-after-two-months-of-intensive-therapy
#4
Suzana Batista Vereza de Oliveira, Ângelo Ferreira Passos, David Jamil Hadad, Lorena Zbyszynski, Pedro Sousa de Almeida Júnior, Luiz Guilherme Schmidt Castellani, Reynaldo Dietze, Moisés Palaci
Tuberculosis (TB) is an infectious disease of global importance with major economic and social burden accounting for 25% of all avoidable deaths in developing countries. Extrapulmonary involvement may occur either in association with clinically apparent pulmonary tuberculosis or in isolation. This cross-sectional descriptive study aimed to evaluate the impact of ocular tuberculosis in visual acuity at baseline and after two months of intensive anti-tuberculous therapy. A sample of 133 pulmonary TB patients, seven disseminated TB, and three pleural TB patients was evaluated...
April 18, 2018: Brazilian Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29643378/the-value-of-radial-endobronchial-ultrasound-guided-bronchial-brushing-in-peripheral-non-squamous-non-small-cell-lung-cancer
#5
Kai-Lun Yu, Tzu-Hsiu Tsai, Chao-Chi Ho, Wei-Yu Liao, Ching-Kai Lin, Chia-Lin Hsu, Jin-Yuan Shih
Radial endobronchial ultrasound (R-EBUS) is one important diagnostic approach in non-small cell lung cancers (NSCLC). However, the small samples obtained from R-EBUS-guided transbronchial biopsies are sometimes insufficient for pathological and molecular diagnosis. Herein, we investigated the suitability of R-EBUS-guided bronchial brushing specimens for NSCLC diagnosis and EGFR genotyping. We enrolled 941 consecutive patients with peripheral pulmonary lesions who underwent R-EBUS. Cytology-positive brushing specimens from non-squamous NSCLC patients were tested for EGFR mutations...
April 11, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29642696/periprocedural-and-perioperatory-management-of-patients-with-tricuspid-valve-disease
#6
Fabrizio Monaco, Ambra L DI Prima, Monica DE Luca, Gaia Barucco, Alberto Zangrillo
Tricuspid regurgitation (TR) is a common valvular lesion which may affect morbidity and mortality. It can be related to an intrinsic abnormality of the tricuspid valve leaflets (organic) or secondary to annular dilatation (functional). Often organic and functional TR coexist in the same patient. A long standing TR is associated with ascites, congestive hepatopathy, peripheral edema, renal failure, and abdominal fullness which significantly affect the outcome. In particular, the perioperative course may be complicated due to both the presence of comorbidities and the development of a severe postoperative right ventricle (RV) dysfunction...
April 11, 2018: Minerva Cardioangiologica
https://www.readbyqxmd.com/read/29626619/a-brief-report-localization-of-pulmonary-ground-glass-opacities-with-folate-receptor-targeted-intraoperative-molecular-imaging
#7
Jarrod D Predina, Andrew Newton, Christopher Corbett, Leilei Xia, Lydia Frenzel Sulyok, Michael Shin, Charuhas Deshpande, Leslie Litzky, Eduardo Barbosa, Philip S Low, John C Kucharczuk, Sunil Singhal
PURPOSE: Intraoperative localization and resection of ill-defined pulmonary ground-glass opacities (GGOs) during minimally invasive pulmonary resection is technically challenging. Current preoperative techniques to facilitate GGO localization include microcoil and hook-wire placement, but have logistic limitations, carry safety concerns, and do not help with margin assessment. In this clinical trial, we explore an alternative method involving near-infrared molecular imaging using a folate receptor-targeted agent, OTL38, to improve localization and margin confirmation of GGOs...
April 4, 2018: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/29616019/the-syk-coupled-c-type-lectin-receptors-dectin-2-and-dectin-3-are-involved-in-paracoccidioides-brasiliensis-recognition-by-human-plasmacytoid-dendritic-cells
#8
Nycolas Willian Preite, Claudia Feriotti, Dhêmerson Souza de Lima, Bruno Borges da Silva, Antônio Condino-Neto, Alessandra Pontillo, Vera Lúcia Garcia Calich, Flávio Vieira Loures
Plasmacytoid dendritic cells (pDCs), which have been extensively studied in the context of the immune response to viruses, have recently been implicated in host defense mechanisms against fungal infections. Nevertheless, the involvement of human pDCs during paracoccidioidomycosis (PCM), a fungal infection endemic to Latin America, has been scarcely studied. However, pDCs were found in the cutaneous lesions of PCM patients, and in pulmonary model of murine PCM these cells were shown to control disease severity...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29600105/fan-shaped-ground-glass-opacity-ggo-as-a-premonitory-sign-of-pulmonary-infarction-a-case-report
#9
Tsutomu Shinohara, Keishi Naruse, Norihiko Hamada, Takashi Yamasaki, Nobuo Hatakeyama, Fumitaka Ogushi
Radiological findings of pulmonary infarction have been well characterized mainly in established infarction. However, the early course CT appearance of patients who develop pulmonary infarction has not yet been fully elucidated. A 50-year-old female with a history of postmenopausal hormone replacement therapy (HRT) presented with dry cough and high-resolution computed tomography (HRCT) findings of fan-shaped segmental ground-glass opacity (GGO) in the right lower lobe. As the parenchymal density in the GGO gradually enlarged over a period of 4 weeks in spite of antibiotic treatment, the patient was referred to our hospital on clinical suspicion of bronchioloalveolar cell carcinoma...
January 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29548309/acantholytic-squamous-cell-carcinoma-of-the-lung-with-marked-lymphogenous-metastases-and-high-titers-of-myeloperoxidase-antineutrophil-cytoplasmic-antibodies-a-case-report
#10
Kenji Yorita, Kazuya Tsuji, Yoko Takano, Naoto Kuroda, Kei Sakamoto, Kaoru Arii, Yukio Yoshimoto, Kimiko Nakatani, Satoshi Ito
BACKGROUND: Acantholytic squamous cell carcinoma (ASQCC), histologically characterized by intercellular bridge loosening, is recognized as a rare variant of squamous cell carcinoma (SQCC). ASQCC may demonstrate a worse prognosis than conventional SQCC. Pulmonary ASQCC is particularly rare; its biological behavior and prognostic data have not been reported. CASE PRESENTATION: We report the clinical and autopsy findings of a 71-year-old Japanese man with pulmonary ASQCC...
March 16, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29535991/pulmonary-inflammatory-myofibroblastic-tumor-in-children-a-case-report-and-brief-review-of-literature
#11
Federica Camela, Marcella Gallucci, Emanuela di Palmo, Salvatore Cazzato, Mario Lima, Giampaolo Ricci, Andrea Pession
The inflammatory myofibroblastic tumor (IMT) is a rare lesion of unclear etiology and variable clinical course, consisting of a proliferation of fibroblasts and myofibroblasts, mixed with inflammatory cells. Synonyms of IMT are inflammatory pseudotumor and plasma cell granuloma reflecting the alleged inflammatory nature attributed to this lesion, even though this heterogeneity in the disease denomination is probably involved in a dispersion of the literature data. Among primary pulmonary neoplasms, it represents the most frequent endobronchial tumor of childhood and beyond the lung it has been described mainly in the bladder, mediastinum and mesentery...
2018: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/29535914/radial-endobronchial-ultrasonography-with-distance-measurement-through-a-thin-bronchoscope-for-the-diagnosis-of-malignant-peripheral-pulmonary-lesions
#12
Su-Juan Zhang, Ming Zhang, Jun Zhou, Qiu-Di Zhang, Qian-Qian Xu, Xiong Xu
Background: Peripheral pulmonary lesions (PPLs) are being discovered more frequently. We investigated efficiency, safety, and influencing factors in radial probe endobronchial ultrasound with distance measurement (rEBUS-D) using a thin bronchoscope during transbronchial biopsy (TBB) for the diagnosis of malignant PPLs. Methods: Patients with PPLs who underwent rEBUS were retrospectively analyzed. Cases with rEBUS-D and a gold-standard final diagnosis were considered...
February 2018: Translational Lung Cancer Research
https://www.readbyqxmd.com/read/29530553/-extragenital-endometriosis-parietal-thoracic-diaphragmatic-and-nervous-lesions-cngof-has-endometriosis-guidelines
#13
B Merlot, S Ploteau, A Abergel, C Rubob, C Hocke, M Canis, X Fritel, H Roman, P Collinet
According to some studies, extragenital endometriosis represents 5% of the localisations. Its prevalence seems to be underestimated. The extra pelvic localisation can make the diagnosis more difficult. Nevertheless, the recurrent and catamenial symptomatology can evoke this pathology. Surgery seems to be the unique efficient treatment for parietal lesions. Pain linked to nervous lesions (peripheric and sacral roots) seems to be underestimated and difficult to diagnose because of various localisations. Neurolysis seems to have encouraging results...
March 9, 2018: Gynecologie, Obstetrique, Fertilite & Senologie
https://www.readbyqxmd.com/read/29525458/ultrasound-guided-percutaneous-needle-biopsy-for-peripheral-pulmonary-lesions-diagnostic-accuracy-and-influencing-factors
#14
Yu-Qing Guo, Xin-Hong Liao, Zhi-Xian Li, Yuan-Yuan Chen, Si-Da Wang, Ji-Han Wang, Xian-Shan Liao, Yuan Luo
A retrospective study was carried out to evaluate the diagnostic accuracy and the factors influencing the diagnostic accuracy of 648 procedures of ultrasound-guided percutaneous needle biopsy (PNB) for peripheral pulmonary lesions (PPLs). We reviewed the histopathology results, the clinical records and the procedure reports of these 648 biopsies and the final diagnoses of 637 PPLs to determine the diagnostic accuracy of ultrasound-guided PNB. Factors that influenced the diagnostic accuracy were assessed by analysis of the biopsy procedures, which were classified as diagnostic cases (true-positive and true-negative) and non-diagnostic cases (false-positive, false-negative and indeterminate)...
March 8, 2018: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/29504866/diagnostic-challenges-of-adult-t-cell-leukemia-lymphoma-in-north-america-a-clinical-histological-and-immunophenotypic-correlation-with-a-workflow-proposal
#15
Michael J Licata, Murali Janakiram, Stephanie Tan, Yanan Fang, Urvi A Shah, Amit K Verma, Yanhua Wang
Adult T-cell leukemia-lymphoma (ATLL) is caused by human T-cell lymphotropic virus type 1 (HTLV-1) and little is known about ATLL endemic to the Caribbean basin and Latin America, designated as western ATLL (W-ATLL). Due to extensive systemic involvement and nonspecific clinical presentation, the initial diagnosis in this cohort can be very challenging. We have diagnosed 60 patients with W-ATLL over a 14-year period. ATLL involves the peripheral blood, bone marrow, and cerebrospinal fluid (CSF) in 98, 87, and 52% cases, respectively; while lymphadenopathy, pulmonary infiltrates, splenomegaly, and hepatomegaly was present in 90, 82, 48, and 45% patients, respectively...
May 2018: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/29488414/factors-affecting-local-control-of-pulmonary-oligometastases-treated-with-stereotactic-body-radiotherapy
#16
Aman Sharma, Marloes Duijm, Esther Oomen-de Hoop, Joachim G Aerts, Cornelis Verhoef, Mischa Hoogeman, Joost Jan Nuyttens
BACKGROUND: Oligometastases refers to a state of limited metastatic disease. The use of local ablative therapies to patients with oligometastases can result in durable state of remission or long-term cure. Stereotactic body radiotherapy (SBRT) is a highly conformal radiation technique that delivers ablative doses to the target. The study aimed to evaluate local control (LC) and identify factors associated with poor LC in patients with pulmonary oligometastases treated with SBRT. Primary endpoint of the study was to assess LC; secondary endpoint was to determine factors associated with LC...
February 28, 2018: Acta Oncologica
https://www.readbyqxmd.com/read/29486178/robotic-endoscopic-airway-challenge-reach-assessment
#17
Alexander C Chen, Colin T Gillespie
PURPOSE: Bronchoscopy for peripheral pulmonary lesions continues to present challenges to clinicians. One potential limitation may be the inability to advance conventional bronchoscopes into close proximity of peripheral lesions prior to biopsy. This study was performed to assess the reach of a robotic endoscopic system within human cadaveric lungs compared to conventional thin bronchoscopes. DESCRIPTION: All segmental bronchi (RB1-10, LB1-10) were accessed in two human cadavers using a conventional thin bronchoscope and robotic endoscope of identical outer diameter...
February 24, 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29484624/deep-sequencing-reveals-the-molecular-pathology-characteristics-between-primary-uterine-leiomyoma-and-pulmonary-benign-metastasizing-leiomyoma
#18
J Jiang, M He, X Hu, C Ni, L Yang
PURPOSE: Pulmonary benign metastasizing leiomyoma (PBML), a rare condition of smooth muscle tumor, originates from women with a history of uterine leiomyoma (LM). Numerous genetic studies of uterine LM have been reported; however, there are few cytogenetic and molecular descriptions of PBML. Therefore, molecular subtyping is necessary to understand the pathogenesis of metastasizing sites. METHODS: Driver gene exon-capture sequencing was performed on one patient's peripheral blood, paraffin samples from primary uterine LM, and lung metastasizing leiomyoma 8 years later...
February 26, 2018: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/29484083/adrenal-mass-of-unusual-etiology-ewing-sarcoma-in-a-young-man
#19
Levent Soydan, Ali Aslan Demir, Elif Sayman, Burcu Onomay Celik, Bala Basak Oven Ustaalioglu
Ewing sarcoma and peripheral primitive neuroectodermal tumor belong to the Ewing sarcoma (ES) family of tumors originating from a primitive neural tube. We report a 31-year-old man who was admitted to the urology clinic with complaints of fever, nausea, and dysuria. A right-sided adrenal mass was detected during ultrasonography. The lesion was then evaluated with magnetic resonance imaging, which showed areas of necrosis amid heterogeneous solid areas. Whole body scan with 2-deoxy-2-[fluorine-18]fluoro-D-glucose integrated with computed tomography and bone scan studies showed pulmonary and osseous metastatic foci...
December 2017: Radiology Case Reports
https://www.readbyqxmd.com/read/29473313/vectorial-localization-of-peripheral-pulmonary-lesion-guided-by-electromagnetic-navigation-a-novel-method-for-diagnostic-surgical-resection-without-dye-marking
#20
Tong Qiu, Baohua Yu, Yunpeng Xuan, Haihong Luan, Wenjie Jiao
We describe a novel method using electromagnetic navigation bronchoscopy (ENB) without dye marking to perform vectorial localization for an impalpable peripheral lesion in the right lower lobe during diagnostic surgical resection in a 52-year-old woman. After the ENB registration process, the anesthetist changed the single-lumen endotracheal tube to a double-lumen endobronchial tube. Guided by the ENB system, the operator delivered the probe of the locatable guide to the planned site through the right lumen of the endobronchial tube...
April 2018: Thoracic Cancer
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