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Peripheral pulmonary lesion

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https://www.readbyqxmd.com/read/29321931/novel-hybrid-cryo-radial-method-an-emerging-alternative-to-ct-guided-biopsy-in-suspected-lung-cancer-a-prospective-case-series-and-description-of-technique
#1
Samantha Herath, Elaine Yap
In diagnosing peripheral pulmonary lesions (PPL), radial endobronchial ultrasound (R-EBUS) is emerging as a safer method in comparison to CT-guided biopsy. Despite the better safety profile, the yield of R-EBUS remains lower (73%) than CT-guided biopsy (90%) due to the smaller size of samples. We adopted a hybrid method by adding cryobiopsy via the R-EBUS Guide Sheath (GS) to produce larger, non-crushed samples to improve diagnostic capability and enhance molecular testing. We report six prospective patients who underwent this procedure in our institution...
February 2018: Respirology Case Reports
https://www.readbyqxmd.com/read/29320832/-diagnostic-value-of-endobronchial-ultrasonography-with-a-guide-sheath-for-peripheral-pulmonary-ground-glass-opacity
#2
L Zhang, M Li, S He, R Tong, J Q Zhu, G Q Wang
Objective: To explore the diagnostic value of endobronchial ultrasonography with a guide sheath (EBUS-GS) for peripheral pulmonary ground glass opacity (GGO). Methods: The clinical data of 27 consecutive patients with 27 GGOs diagnosed by EBUS-GS between November 2014 to December 2015 in our Cancer Hospital were retrospectively analyzed. The average age of these 27 patients, including 9 males and 18 females, was 59±11 years. The median lesion size of the 27 GGOs was 2.9±1.2 cm, including 24 mixed GGOs and 3 pure GGOs...
November 12, 2017: Chinese Journal of Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/29319027/comparison-of-diagnostic-yield-and-safety-profile-of-radial-endobronchial-ultrasound-guided-bronchoscopic-lung-biopsy-with-computed-tomography-guided-percutaneous-needle-biopsy-in-evaluation-of-peripheral-pulmonary-lesions-a-randomized-controlled-trial
#3
Ayush Gupta, Jagdish Chander Suri, Dipak Bhattacharya, Manas Kamal Sen, Shibdas Chakrabarti, Abhijeet Singh, Tulsi Adhikari
BACKGROUND: Peripheral pulmonary lesions (PPLs) pose a diagnostic challenge, and the optimal investigation in many such cases remains unclear. Computed tomography (CT)-guided percutaneous needle biopsy (CT-PNB) has been the modality of choice for such lesions with a high diagnostic accuracy but with high rates of pneumothorax. Endobronchial ultrasound (EBUS) with a radial probe is an alternate diagnostic modality with increased diagnostic yield of bronchoscopy in the evaluation of PPL...
January 2018: Lung India: Official Organ of Indian Chest Society
https://www.readbyqxmd.com/read/29308309/the-t-cell-repertoire-in-tumors-overlaps-with-pulmonary-inflammatory-lesions-in-patients-treated-with-checkpoint-inhibitors
#4
Heinz Läubli, Viktor H Koelzer, Matthias S Matter, Petra Herzig, Béatrice Dolder Schlienger, Mark Nikolaj Wiese, Didier Lardinois, Kirsten D Mertz, Alfred Zippelius
Cancer immunotherapy with antibodies targeting immune checkpoints such as the PD-1/PD-L1 pathway have emerged as breakthrough treatment for multiple solid tumors with high response rates and durable remissions. Despite the benefit for patients and encouraging safety profile, severe inflammatory reactions are observed in some patients. Such immune-related adverse events (irAEs) frequently lead to temporary or permanent cessation of the treatment and require systemic immunosuppression yet underlying mechanisms of irAEs are not known in detail...
2018: Oncoimmunology
https://www.readbyqxmd.com/read/29277183/-diagnostic-utility-of-electromagnetic-navigation-bronchoscopy-combined-with-%C3%A2-radial-probe-endobronchial-ultrasound-in-peripheral-pulmonary-lesions
#5
Haitao Huang, Shaomu Chen, Liangbin Pan, Ke Chen, Feirong Yao, Haitao Ma
BACKGROUND: With the application of high resolution computed tomography (CT), a large number of peripheral lung lesions were found. It put forward new challenge on clinical diagnosis and treatment for these peripheral lung lesions. Electromagnetic navigation bronchoscopy (ENB) and radial endobronchial ultrasound probe (R-EBUS) are new technologies used for the diagnosis of peripheral lung lesions. The aim of this study is to explore the application value of ENB combined with R-EBUS in the diagnosis of peripheral pulmonary lesions...
December 20, 2017: Zhongguo Fei Ai za Zhi, Chinese Journal of Lung Cancer
https://www.readbyqxmd.com/read/29258402/pathology-of-the-emerging-mycobacterium-tuberculosis-complex-pathogen-mycobacterium-mungi-in-the-banded-mongoose-mungos-mungo
#6
Kathleen A Alexander, Peter N Laver, Mark C Williams, Claire E Sanderson, Carly Kanipe, Mitchell V Palmer
Wild banded mongooses ( Mungos mungo) in northeastern Botswana and northwest Zimbabwe are infected with a novel Mycobacterium tuberculosis complex (MTC) pathogen, Mycobacterium mungi. We evaluated gross and histologic lesions in 62 infected mongooses (1999-2017). Many tissues contained multifocal irregular, lymphohistiocytic to granulomatous infiltrates and/or multifocal or coalescing noncaseating to caseating granulomas with variable numbers of intralesional acid-fast bacilli. Over one-third of nasal turbinates examined had submucosal lymphohistiocytic to granulomatous infiltrates, erosion and ulceration of the nasal mucosa, bony remodeling, and nasal distortion...
January 1, 2017: Veterinary Pathology
https://www.readbyqxmd.com/read/29239031/molecular-alterations-of-neuroendocrine-tumours-of-the-lung
#7
REVIEW
Giulio Rossi, Luca Bertero, Caterina Marchiò, Mauro Papotti
Neuroendocrine tumours of the lung comprise low [typical carcinoid (TC)], intermediate [atypical carcinoid (AC)] and high-grade [small-cell lung cancer (SCLC) and large-cell neuroendocrine carcinoma (LCNEC)] malignancies, while a pre-invasive lesion [diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH)] may generate a subset of peripheral carcinoid tumours. These neoplasms are differentiated conventionally based on mitotic rate, presence of necrosis and cytological details, according to the 2015 World Health Organisation (WHO) classification...
January 2018: Histopathology
https://www.readbyqxmd.com/read/29236566/genome-profile-in-a-extremely-rare-case-of-pulmonary-sclerosing-pneumocytoma-presenting-with-diffusely-scattered-nodules-in-the-right-lung
#8
Xiangshan Fan, Ling Lin, Jianjun Wang, Yu Wang, Anning Feng, Ling Nie, Hongyan Wu, Fanqing Meng, Haodong Xu
BACKGROUND: Pulmonary sclerosing pneumocytoma (PSP) typically presents solitary and peripheral mass, while only rarely cases display unusual multiple lesions. We reported a extremely rare case of PSP with diffusely-scattered nodules in the right lung. CASE PRESENTATION: Diffusely round-shaped nodular shadows in the right lung were found by CT scan in a 31-year-old Chinese woman. The patient undergone the right pneumnectomy. Grossly, numerous small nodules, up to 2...
December 13, 2017: Cancer Biology & Therapy
https://www.readbyqxmd.com/read/29229202/-endobronchial-ultrasound-for-peripheral-pulmonary-lesions
#9
REVIEW
B Escarguel
No abstract text is available yet for this article.
December 8, 2017: Revue des Maladies Respiratoires
https://www.readbyqxmd.com/read/29228929/virtual-bronchoscopic-navigation-without-x-ray-fluoroscopy-to-diagnose-peripheral-pulmonary-lesions-a-randomized-trial
#10
Fumihiro Asano, Takashi Ishida, Naofumi Shinagawa, Noriaki Sukoh, Masaki Anzai, Kenya Kanazawa, Akifumi Tsuzuku, Satoshi Morita
BACKGROUND: Transbronchial biopsy for peripheral pulmonary lesions is generally performed under X-ray fluoroscopy. Virtual bronchoscopic navigation (VBN) is a method in which virtual images of the bronchial route to the lesion are produced based on CT images obtained before VBN, and the bronchoscope is guided using these virtual images, improving the diagnostic yield of peripheral pulmonary lesions. VBN has the possibility of eliminating the need for X-ray fluoroscopy in the bronchoscopic diagnosis of peripheral lesions...
December 11, 2017: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/29221268/the-introduction-of-electromagnetic-navigation-bronchoscopy-for-the-diagnosis-of-small-pulmonary-peripheral-lesions-in-an-asian-population
#11
Ye Gu, Shanhao Chen, Jingyun Shi, Chunyan Wu, Zongmei Wen, Hong Shi, Baomei Wu, Xin Xu, Hao Wang
Background: Electromagnetic navigation bronchoscopy (ENB) is emerging as a useful new technique for diagnosing small pulmonary peripheral lesions (SPPLs). However, the accuracy and efficiency of ENB have not been investigated in Asian populations where the differential diagnoses for SPPLs may be different. To analyze this question, this study included patients who received diagnostic ENB followed by surgery for the excision of SPPLs. Methods: Consecutive patients referred to the Department of Thoracic Surgery, Shanghai Pulmonary Hospital (Tongji University), between May 2014 and April 2015 were recruited...
September 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29214064/bronchoscopy-for-the-diagnosis-of-peripheral-lung-lesions
#12
REVIEW
Samjot Singh Dhillon, Kassem Harris
Peripheral pulmonary lesions (PPLs) are generally considered as lesions in the peripheral one-third of the lung although a precise definition and radiographic anatomical landmarks separating central and peripheral lesion does not yet exist. The radiographic detection of such lesions has increased significantly with the adoption of lung cancer screening programs. These lesions are not directly visible by regular flexible bronchoscopes as they are usually distal to the lobar and segmental bronchi. Traditionally, depending on location and clinical stage at presentation, these lesions were typically sampled by computerized tomography (CT) guided needle or surgical biopsy although some centers also used ultrasound and fluoroscopy guided percutaneous needle biopsy...
September 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29204340/evaluation-of-coexistence-of-cancer-and-active-tuberculosis-16-case-series
#13
Beyhan Çakar, Aydın Çiledağ
Introduction: Tuberculosis is an important risk factor for cancer. Pulmonary TB and lung cancer(LC) may mimic each other especially in the aspect of the clinical and radiological features. The aim of the study was to evaluate the features and risk factors of cases with coexistence cancer and active TB. Methodology: We retrospectively reviewed the medical records of patients with coexisting TB and cancer a period from 2009 to 2014. We evaluated demographic data, the ways diagnosis of TB cases, the location of TB and cancer, TB treatment results of the cases...
2018: Respiratory Medicine Case Reports
https://www.readbyqxmd.com/read/29174934/primary-lesions-that-may-imitate-metastatic-tumors-histologically-a-selective-review
#14
REVIEW
Mark R Wick
Several primary pathologic entities in diverse anatomic locations have the potential to simulate metastatic neoplasms histologically. Their misinterpretation as such may result in needless and extensive clinical evaluations that are intended to detect a presumed malignancy at another site. More importantly, mistakes of this type can deprive patients of surgical excisions that could be curative. This presentation considers a review of selected primary lesions that can simulate metastases. They include hemangioblastoma, glioblastoma and meningioma with epithelial metaplasia, choroid plexus carcinomas, primary neuroendocrine carcinomas in unusual locations, special forms of sinonasal and salivary glandular adenocarcinoma, clear-cell thyroid carcinomas, unusual microscopic subtypes of pulmonary adenocarcinoma, epithelioid myomelanocytomas ("sugar tumors"), mesotheliomas, primary thymic carcinomas, endodermal choristomas of the interatrial myocardium, peripheral cholangiocarcinoma, adrenocortical carcinoma, adenocarcinomas of the urinary bladder, mucinous and "rhabdoid" tumors of the ovaries, rete testis adenocarcinomas, interdigitating dendritic-cell sarcoma of lymph nodes, selected sweat gland carcinomas, cutaneous Merkel cell carcinoma, primary dermal and subcutaneous melanoma, mucosal and visceral melanomas, epithelioid sarcoma, clear-cell sarcoma, and adamantinoma of long bones...
November 17, 2017: Seminars in Diagnostic Pathology
https://www.readbyqxmd.com/read/29156147/electromagnetic-navigational-bronchoscopy-versus-ct-guided-percutaneous-sampling-of-peripheral-indeterminate-pulmonary-nodules-a-cohort-study
#15
Kavita M Bhatt, Yasmeen K Tandon, Ruffin Graham, Charles T Lau, Jason K Lempel, Joseph T Azok, Peter J Mazzone, Erika Schneider, Nancy A Obuchowski, Michael A Bolen
Purpose To compare the diagnostic yield and complication rates of electromagnetic navigational bronchoscopic (ENB)-guided and computed tomography (CT)-guided percutaneous tissue sampling of lung nodules. Materials and Methods Retrospectively identified were 149 patients sampled percutaneously with CT guidance and 146 patients who underwent ENB with transbronchial biopsy of a lung lesion between 2013 and 2015. Clinical data, incidence of complications, and nodule pathologic analyses were assessed through electronic medical record review...
November 20, 2017: Radiology
https://www.readbyqxmd.com/read/29153417/the-efficacy-of-transbronchial-needle-aspiration-with-endobronchial-ultrasonography-using-a-guide-sheath-for-peripheral-pulmonary-lesions-suspected-to-be-lung-cancer
#16
Ken Arimura, Yasuo Sekine, Kenzo Hiroshima, Akitoshi Sato, Mizue Hasegawa, Hideki Katsura, Etsuko Tagaya, Mitsuko Kondo, Jun Tamaoki
BACKGROUND: The efficacy of transbronchial needle aspiration (TBNA) with endobronchial ultrasonography using a guide sheath (EBUS-GS) for cases of peripheral pulmonary lesions (PPLs) has not been well established. The purpose of this study was to evaluate the efficacy of TBNA with EBUS-GS for PPLs. METHODS: We evaluated 130 patients suspected to have lung cancer who underwent transbronchial brushing (brushing), transbronchial biopsy (TBB), and TBNA with EBUS-GS...
November 2017: Respiratory Investigation
https://www.readbyqxmd.com/read/29151936/multiple-guided-technologies-based-on-radial-probe-endobronchial-ultrasound-for-the-diagnosis-of-solitary-peripheral-pulmonary-lesions-a-single-center-study
#17
Huang Haidong, Ning Yunye, Zhang Wei, Paul Zarogoulidis, Wolfgang Hohenforst-Schmidt, Yan-Gao Man, Yang Yuguang, Dong Yuchao, Bai Chong
Objective To evaluate the value of multiple guided technologies based on radial probe endobronchial ultrasound (R-EBUS) in the application of the diagnosis of solitary pulmonary peripheral lesions (PPLs). Methods Analysis of diagnostic yield in 4 groups patients with different combined multiple guided technologies based on R-EBUS, 94 patients with 94 solitary PPLs from Mar, 2013 to Nov, 2014 in Changhai Hospital. Results The overall diagnostic yield was 75% (70/94), the diagnostic yield of Group A (R-EBUS) was 62%(16/26), Group B (R-EBUS with guided sheath, EBUS-GS) was 76% (34/45), Group C (EBUS-GS with fluoroscopy) was 82% (9/11), Group D (virtual bronchoscopic navigation guided EBUS-GS with fluoroscopy) was 92% (11/12)...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/29143683/the-progression-of-heartworm-associated-respiratory-disease-hard-in-spf-cats-18%C3%A2-months-after-dirofilaria-immitis-infection
#18
A Ray Dillon, Bryon L Blagburn, Michael Tillson, William Brawner, Betsy Welles, Calvin Johnson, Russell Cattley, Pat Rynders, Sharron Barney
BACKGROUND: Heartworm-associated respiratory disease (HARD) in cats is induced by the arrival and death of immature adult Dirofilaria immitis in the pulmonary system and is indistinguishable from mature adult heartworm infection. METHODS: A controlled, blind research study investigated the long-term (18 months post infection, PI) consequences of the inflammatory response associated with the death of immature adult heartworms in cats. Three groups of cats, 10 per group, were infected with 100 third-stage (L3) larvae by subcutaneous injection...
November 9, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/29143661/heartworm-associated-respiratory-disease-hard-induced-by-immature-adult-dirofilaria-immitis-in-cats
#19
A Ray Dillon, Byron L Blagburn, Michael Tillson, William Brawner, Betsy Welles, Calvin Johnson, Russell Cattley, Pat Rynders, Sharron Barney
BACKGROUND: A controlled, blind research study was conducted to define the initial inflammatory response and lung damage associated with the death of immature adult Dirofilaria immitis in cats as compared with cats developing adult heartworm infections and cats on preventive medication. METHODS: Three groups of cats were utilized, 10 per group. All cats were infected with 100 third-stage (L3) larvae by subcutaneous injection. Group A cats were treated topically with selamectin (Revolution®; Zoetis) per label directions at 28 days post infection (PI) and once monthly for 8 months...
November 9, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/29124003/inflammatory-myofibroblastic-tumour-a-case-report-and-a-clinical-update
#20
Neelam N Andrade, Paul C Mathai, Rajpari Kamil, Neha Aggarwal
The Inflammatory myofibroblastic tumor (IMT) is a heterogeneous group of rare lesions consisting predominantly of inflammatory cells and myofibroblastic spindle cells. Head and neck IMTs account for 14 to 18% of extra-pulmonary IMTs [lungs being the most commonly affected regions]. On account of its ambiguous clinical presentation, an IMT needs to be differentiated from other infectious, granulomatous, autoimmune and neoplastic lesions on the basis of histopathologic findings and immunohistochemical analysis...
September 2017: Journal of Oral Biology and Craniofacial Research
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