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Peripheral pulmonary lesion

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https://www.readbyqxmd.com/read/29143683/the-progression-of-heartworm-associated-respiratory-disease-hard-in-spf-cats-18%C3%A2-months-after-dirofilaria-immitis-infection
#1
A Ray Dillon, Bryon L Blagburn, Michael Tillson, William Brawner, Betsy Welles, Calvin Johnson, Russell Cattley, Pat Rynders, Sharron Barney
BACKGROUND: Heartworm-associated respiratory disease (HARD) in cats is induced by the arrival and death of immature adult Dirofilaria immitis in the pulmonary system and is indistinguishable from mature adult heartworm infection. METHODS: A controlled, blind research study investigated the long-term (18 months post infection, PI) consequences of the inflammatory response associated with the death of immature adult heartworms in cats. Three groups of cats, 10 per group, were infected with 100 third-stage (L3) larvae by subcutaneous injection...
November 9, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/29143661/heartworm-associated-respiratory-disease-hard-induced-by-immature-adult-dirofilaria-immitis-in-cats
#2
A Ray Dillon, Byron L Blagburn, Michael Tillson, William Brawner, Betsy Welles, Calvin Johnson, Russell Cattley, Pat Rynders, Sharron Barney
BACKGROUND: A controlled, blind research study was conducted to define the initial inflammatory response and lung damage associated with the death of immature adult Dirofilaria immitis in cats as compared with cats developing adult heartworm infections and cats on preventive medication. METHODS: Three groups of cats were utilized, 10 per group. All cats were infected with 100 third-stage (L3) larvae by subcutaneous injection. Group A cats were treated topically with selamectin (Revolution®; Zoetis) per label directions at 28 days post infection (PI) and once monthly for 8 months...
November 9, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/29124003/inflammatory-myofibroblastic-tumour-a-case-report-and-a-clinical-update
#3
Neelam N Andrade, Paul C Mathai, Rajpari Kamil, Neha Aggarwal
The Inflammatory myofibroblastic tumor (IMT) is a heterogeneous group of rare lesions consisting predominantly of inflammatory cells and myofibroblastic spindle cells. Head and neck IMTs account for 14 to 18% of extra-pulmonary IMTs [lungs being the most commonly affected regions]. On account of its ambiguous clinical presentation, an IMT needs to be differentiated from other infectious, granulomatous, autoimmune and neoplastic lesions on the basis of histopathologic findings and immunohistochemical analysis...
September 2017: Journal of Oral Biology and Craniofacial Research
https://www.readbyqxmd.com/read/29118338/sialidase-inhibitors-attenuate-pulmonary-fibrosis-in-a-mouse-model
#4
Tejas R Karhadkar, Darrell Pilling, Nehemiah Cox, Richard H Gomer
Fibrosis involves increasing amounts of scar tissue appearing in a tissue, but what drives this is unclear. In fibrotic lesions in human and mouse lungs, we found extensive desialylation of glycoconjugates, and upregulation of sialidases. The fibrosis-associated cytokine TGF-β1 upregulates sialidases in human airway epithelium cells, lung fibroblasts, and immune system cells. Conversely, addition of sialidases to human peripheral blood mononuclear cells induces accumulation of extracellular TGF-β1, forming what appears to be a sialidase - TGF-β1 - sialidase positive feedback loop...
November 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29113271/significance-of-imaging-and-clinical-features-in-the-differentiation-between-primary-and-secondary-pulmonary-lymphoma
#5
Yuhao Dong, Miaoyu Zeng, Bin Zhang, Lujun Han, Entao Liu, Zhouyang Lian, Jing Liu, Changhong Liang, Shuixing Zhang
The aim of the present study was to analyze the differences in imaging and clinical features between primary pulmonary lymphoma (PPL) and secondary pulmonary lymphoma (SPL) to provide insight into pulmonary lymphoma for an improved clinical diagnosis. A retrospective study of 38 patients with pulmonary lymphoma (19 PPL and 19 SPL) treated between September 1, 2006, and December 31, 2015, was performed. The clinical manifestations, and computed tomography (CT) and positron emission tomography-CT images of each case were collected...
November 2017: Oncology Letters
https://www.readbyqxmd.com/read/29108823/cocaine-and-anca-associated-vasculitis-like-syndromes-a-case-series
#6
REVIEW
Sujith Subesinghe, Sander van Leuven, Leena Yalakki, Shirish Sangle, David D'Cruz
OBJECTIVES: We analysed the spectrum of clinical manifestations of cocaine associated pseudovasculitis. METHODS: Clinical, serological, radiological and histological features of 14 patients with cocaine pseudovasculitis syndromes were included. RESULTS: Twelve patients had significant sinus thickening or erosive disease. Other multi-system manifestations included vasculitic rashes, pulmonary lesions and peripheral neuropathy. All patients had positive ANCA titres at presentation...
November 3, 2017: Autoimmunity Reviews
https://www.readbyqxmd.com/read/29104652/plain-and-contrast-enhanced-chest-computed-tomography-scan-findings-of-pulmonary-cryptococcosis-in-immunocompetent-patients
#7
Rongshui Yang, Yan Yan, Yuhuan Wang, Xiaohuan Liu, Xinhui Su
Pulmonary cryptococcosis is most commonly reported in immunocompromised patients, whereas immunocompetent hosts are rarely affected and may be asymptomatic, resulting in reduced diagnostic performance of computed tomography (CT) imaging. Thus, the aim of the present study was to review the plain and contrast-enhanced chest CT scan findings of primary pulmonary cryptococcosis in immunocompetent patients, with the aim of improving the diagnosis of this type of pulmonary disease. In the present study, a total of 27 immunocompetent patients of clinically confirmed pulmonary cryptococcosis were analyzed retrospectively...
November 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29063872/endobronchial-ultrasonography-using-a-guide-sheath-technique-for-diagnosis-of-peripheral-pulmonary-lesions
#8
REVIEW
Lei Zhang, Hongxu Wu, Guiqi Wang
Endobronchial ultrasonography using a guide sheath (EBUS-GS) is a novel method used for collecting peripheral pulmonary lesion (PPL) samples. EBUS-GS is performed by introducing a guide sheath-covered miniprobe into the target bronchus and then withdrawing the miniprobe after lesion detection, leaving the guide sheath in situ as a working channel for obtaining lesion samples. EBUS-GS can improve PPL diagnosis rates and be used for obtaining specimens for molecular analysis. In this review, we discuss the clinical applications of EBUS-GS, the factors that affect its diagnostic sensitivity, and potential complications...
September 2017: Endoscopic Ultrasound
https://www.readbyqxmd.com/read/29053224/programmed-death-ligand-1-testing-of-lung-cancer-cytology-specimens-obtained-with-bronchoscopy
#9
Sean P Stoy, Lauren Rosen, Jeffrey Mueller, Septimiu Murgu
BACKGROUND: Programmed death-ligand 1 (PD-L1) expression testing is recommended by guidelines for patients with advanced non-small cell lung cancer (NSCLC). The primary objective of the current study was to determine the success rate of PD-L1 testing from cytology cell block samples obtained by bronchoscopic needle aspiration. The secondary objective was the assessment of the difference in specimen adequacy acquired via needles of different gauges. METHODS: Patients with NSCLC who underwent bronchoscopic needle aspirations for which PD-L1 testing was requested between November 1, 2016, and February 6, 2017, were included in the current analysis...
October 20, 2017: Cancer
https://www.readbyqxmd.com/read/29041924/the-value-of-repeat-radial-probe-endobronchial-ultrasound-guided-transbronchial-biopsy-after-initial-non-diagnostic-results-in-patients-with-peripheral-pulmonary-lesions
#10
Chun-Ta Huang, Yi-Ju Tsai, Chao-Chi Ho, Chong-Jen Yu
BACKGROUND: Radial-probe endobronchial ultrasound (rEBUS)-guided transbronchial biopsy (TBB) is invaluable in the diagnosis of peripheral pulmonary lesions (PPLs); however, in certain instances, the procedure has to be repeated because of initial non-diagnostic procedure(s). Little if any literature has been published on this issue. Therefore, the aim of this study was to investigate the utility of repeat rEBUS-guided TBB in achieving a definitive diagnosis of PPLs. METHODS: All patients who underwent rEBUS-guided TBB of PPLs at National Taiwan University Hospital between 2011 and 2015 and had a repeat procedure after non-diagnostic initial procedures were identified as the study subjects...
October 17, 2017: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/28994206/the-computed-tomographic-tree-in-bud-pattern-characterization-and-comparison-with-radiographic-and-clinical-findings-in-36-cats
#11
Harriet Hahn, Swan Specchi, Isabelle Masseau, Carol Reinero, Ghita Benchekroun, Jaime Rechy, Gabriela Seiler, Pascaline Pey
In humans, a CT "tree-in-bud" pattern has been described as a characteristic of centrilobular bronchiolar dilation, with bronchiolar plugging by mucus, pus, or fluid. Aims of this retrospective, descriptive, multi-center study were to characterize the CT appearance of a "tree-in-bud" pattern in a group of cats, and compare this pattern with radiographic and clinical findings. Databases from four hospitals were searched during the period of January 2012 to September 2015 and cats with thoracic radiographs, thoracic CT scans and CT reports describing findings consistent with a "tree-in-bud" pattern were included...
October 9, 2017: Veterinary Radiology & Ultrasound
https://www.readbyqxmd.com/read/28942887/bronchoscopic-diagnosis-of-peripheral-pulmonary-lung-cancer-employing-sedation-with-fentanyl-and-midazolam
#12
Daisuke Minami, Takamasa Nakasuka, Chihiro Ando, Yoshitaka Iwamoto Md, Ken Sato, Keiichi Fujiwara, Takuo Shibayama, Toshirou Yonei Md PhD, Toshio Sato
BACKGROUND: Sedation with fentanyl and midazolam during bronchoscopic examination is commonly employed by pulmonary physicians in the USA and Europe. We assessed the efficacy of such sedation in the bronchoscopic diagnosis of peripheral lung cancer. METHODS: We retrospectively evaluated data from 102 patients who underwent transbronchial biopsies (TBB) for diagnosis of peripheral lung cancer. Bronchoscopies with and without fentanyl were performed in 61 (group A) and 41 (group B) patients, respectively...
September 2017: Respiratory Investigation
https://www.readbyqxmd.com/read/28938635/distribution-of-circulating-tumor-dna-in-lung-cancer-analysis-of-the-primary-lung-and-bone-marrow-along-with-the-pulmonary-venous-and-peripheral-blood
#13
Taichiro Goto, Yosuke Hirotsu, Kenji Amemiya, Takahiro Nakagomi, Daichi Shikata, Yujiro Yokoyama, Kenichiro Okimoto, Toshio Oyama, Hitoshi Mochizuki, Masao Omata
Circulating tumor DNA (ctDNA), extracted from plasma, is a non-invasive surrogate biomarker. However, the distribution of ctDNA in the body still remains to be elucidated. In this study, resected lung tumors, with simultaneous blood and bone marrow samples, were analyzed to elucidate the distribution of ctDNA. Rib bone marrow, pulmonary venous blood (Pul.V) and peripheral blood (Peri.B) were obtained from 30 patients. The liquid samples were divided into cell pellets and supernatant by centrifugation; a total of 212 DNA samples were subjected to massively parallel sequencing...
August 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28901312/magnetic-resonance-imaging-evaluation-after-radiofrequency-ablation-for-malignant-lung-tumors
#14
Jin Chen, Zheng-Yu Lin, Zhi-Bin Wu, Zhong-Wu Chen, Yi-Ping Chen
OBJECTIVE: The objective of this study was to investigate magnetic resonance imaging (MRI) assessment of the therapeutic response in small lung malignancies (<3 cm) immediately after radiofrequency ablation (RFA). MATERIALS AND METHODS: This is a retrospective analysis of MRI performance in 24 cases of small lung tumors (16 primary, 8 metastatic; 20 patients) immediately, post-RFA, and at follow-up. Variables measured included maximum diameters of tumors on pre-RFA MRI, central areas of low signal intensity (SI) on post-RFA T2-weighted images (T2WIs), and central areas of high SI on post-RFA T1WIs...
2017: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/28879079/intrathoracic-ganglioneuroma-presenting-as-an-endobronchial-mass
#15
Brandon T Nokes, Coralie P Baumann, Kristopher W Cummings, Brandon T Larsen, Rodrigo Cartin-Ceba, Karen L Swanson
Peripheral nerve sheath tumors (PNST) are exceedingly rare, especially outside of the posterior mediastinum. These tumors represent less than 1% of pulmonary tumors. Very few pulmonary PNSTs are ganglioneuromas. We present a case of a ganglioneuroma presenting as an endobronchial mass. CASE PRESENTATION: An 80 year old male was seen in pulmonary clinic for routine cancer screening. He had a 60-pack year smoking history. CT evaluation noted a 1cm right lower lobe endobronchial lesion. This lesion was present since 2012 and had slightly increased in size since that time from 8mm (Figure 1)...
2017: Respiratory Medicine Case Reports
https://www.readbyqxmd.com/read/28869233/meropenem-a-possible-new-culprit-in-eosinophilic-lung-diseases
#16
Nathalie Abi Hatem, Sabrina Campbell, Edmundo Rubio, Anthony Lukas Loschner
Eosinophilic lung diseases are a diverse group of pulmonary disorders with an extensive list of differential diagnoses. Multiple drugs particularly antibiotics can cause pulmonary eosinophilia with variable pulmonary manifestations. Cutaneous drug reactions are common. Diagnosis is usually made on clinical history and blood eosinophilia with an accumulation of eosinophils in alveolar spaces on histologic analysis. Imaging findings are nonspecific. Stopping the offending agent is often enough while a short course of corticosteroids can hasten recovery...
September 2017: Lung India: Official Organ of Indian Chest Society
https://www.readbyqxmd.com/read/28861589/erratum-to-ct-guided-percutaneous-trans-scapular-lung-biopsy-in-the-diagnosis-of-peripheral-pulmonary-lesion-nodules-of-the-superior-lobes-using-large-needles
#17
Alberto Rebonato, Daniele Maiettini, Marco Andolfi, Matthias J Fischer, Jacopo Vannucci, Giulio Metro, Antonio Basile, Michele Duranti, Michele Rossi
No abstract text is available yet for this article.
August 31, 2017: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/28858088/placental-transmogrification-of-the-lung-case-report-and-systematic-review-of-the-literature
#18
REVIEW
Dong-Jie Ma, Hong-Sheng Liu, Shan-Qing Li, Xiao-Yun Zhou, Yu-Shang Cui, Huan-Wen Wu, Wei-Xun Zhou
OBJECTIVE: Placental transmogrification of the lung (PTL) is rare cystic lesion. Thus, we summarized the characteristics of PTL to explore the strategy of diagnosis and treatment. METHODS: Two patients pathologically confirmed PTL were treated in our hospital. Retrospectively analysis was performed on such 2 cases and 34 cases of PTL reported in abroad. The basic information and clinical characteristics from each patient were gathered and analyzed. RESULTS: The imaging findings of 2 patients were the pulmonary solid mass with peripheral multiple pulmonary bullae...
September 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28839991/combination-of-virtual-bronchoscopic-navigation-endobronchial-ultrasound-and-rapid-on-site-evaluation-for-diagnosing-small-peripheral-pulmonary-lesions-a-prospective-phase-ii-study
#19
Toshiya Maekura, Chikatoshi Sugimoto, Akihiro Tamiya, Nobuhiko Saijo, Yoko Naoki, Taro Koba, Yohei Kimura, Yoshinobu Matsuda, Masaki Kanazu, Naoko Takeuchi, Yumiko Sasaki, Yujiro Naito, Taisuke Tsuji, Reiko Sugawara, Takehiko Kobayashi, Keiko Nakao, Yoshihiko Taniguchi, Kyoichi Okishio, Naoki Omachi, Takahiko Kasai, Shinji Atagi
BACKGROUND: The diagnostic yield of peripheral pulmonary lesions (PPLs) by flexible bronchoscopy (FB) is still insufficient. To improve the diagnostic yield of bronchoscopy, several techniques such as endobronchial ultrasound (EBUS), virtual bronchoscopic navigation (VBN), and rapid on-site evaluation (ROSE) have been examined. The primary purpose of the present study was to evaluate the usefulness of combining EBUS, VBN, and ROSE for diagnosing small PPLs. METHODS: Patients with PPLs 30 mm or less on chest computed tomography (CT) were prospectively enrolled...
July 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28834894/value-of-radial-probe-endobronchial-ultrasound-guided-transbronchial-biopsy-and-computer-tomography-guided-transthoracic-needle-aspiration-in-the-diagnosis-of-peripheral-pulmonary-lesions
#20
Qiudi Zhang, Sujuan Zhang, Xiong Xu, Qianqian Xu, Jun Zhou
Computer tomography-guided transthoracic needle aspiration (CT-TTNA) is a minimally invasive technique for sampling peripheral lung lesions. Radial endobronchial ultrasound-guided transbronchial biopsy (rEBUS-TBB) is an alternative. The present study analyzed and compared rEBUS-TBB and CT-TTNA in the diagnosis of peripheral pulmonary lesions (PPL).Clinical data of 513 patients with PPL who underwent an rEBUS-TBB or CT-TTNA examination were analyzed retrospectively. The positive diagnostic rate, complication rate, and influencing factors of the 2 methods were compared...
August 2017: Medicine (Baltimore)
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