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https://www.readbyqxmd.com/read/29104625/high-expression-of-long-chain-acyl-coenzyme-a-synthetase-1-in-peripheral-blood-may-be-a-molecular-marker-for-assessing-the-risk-of-acute-myocardial-infarction
#1
Liping Yang, Yushuang Yang, Daoyuan Si, Kaiyao Shi, Dongna Liu, Heyu Meng, Fanbo Meng
The current study aimed to investigate whether the increased expression of long chain acyl-coenzymeA synthetase 1 (ACSL1) in peripheral blood leukocytes (PBL) may be a molecular marker for the genetic evaluation of acute myocardial infarction (AMI). The mechanism of action of ACSL1 in the pathogenesis of AMI was also investigated. A total of 75 patients with AMI and 70 individuals without coronary heart disease were selected to participate in the present study. The demographic and clinical information of the enrolled subjects was recorded...
November 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29101395/a-teleost-cd46-is-involved-in-the-regulation-of-complement-activation-and-pathogen-infection
#2
Mo-Fei Li, Zhi-Hai Sui, Li Sun
In mammals, CD46 is involved in the inactivation of complement by factor I (FI). In teleost, study on the function of CD46 is very limited. In this study, we examined the immunological property of a CD46 molecule (CsCD46) from tongue sole, a teleost species with important economic value. We found that recombinant CsCD46 (rCsCD46) interacted with FI and inhibited complement activation in an FI-dependent manner. rCsCD46 also interacted with bacterial pathogens via a different mechanism to that responsible for the FI interaction, involving different rCsCD46 sites...
November 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29096591/comparison-between-flipped-classroom-and-lecture-based-classroom-in-ophthalmology-clerkship
#3
Fen Tang, Chuan Chen, Yi Zhu, Chengguo Zuo, Yimin Zhong, Nan Wang, Lijun Zhou, Yuxian Zou, Dan Liang
BACKGROUND: In recent years, the flipped classroom method of teaching has received much attention in health sciences education. However, the application of flipped classrooms in ophthalmology education has not been well investigated. OBJECTIVE: The goal of this study was to investigate the effectiveness and acceptability of the flipped classroom approach to teaching ophthalmology at the clerkship level. DESIGN: Ninety-five fourth year medical students in an ophthalmology clerkship were randomly divided into two groups...
2017: Medical Education Online
https://www.readbyqxmd.com/read/29092557/articulatory-characteristics-of-preboundary-lengthening-in-interaction-with-prominence-on-tri-syllabic-words-in-american-english
#4
Sahyang Kim, Jiyoung Jang, Taehong Cho
This study investigated articulation of preboundary lengthening (PBL) in tri-syllabic pseudo words (bábaba, babába, bababá) in American English. Results from 10 speakers showed that PBL was modulated by the degree of prominence, i.e., the less prominent, the more PBL. PBL was attracted to the penultimate stressed syllable but only when the word received no pitch accent whereas the antepenultimate syllable showed no PBL. Kinematically, PBL was accompanied by a larger movement along with an increase in peak velocity, showing a kind of boundary-related articulatory strengthening, although there was some evidence of temporal expansion possibly due to lowered stiffness...
October 2017: Journal of the Acoustical Society of America
https://www.readbyqxmd.com/read/29092002/pstab-prediction-of-stable-mutants-unfolding-curves-stability-maps-and-protein-electrostatic-frustration
#5
Soundhararajan Gopi, Devanshu Devanshu, Praveen Krishna, Athi N Naganathan
Summary: We present a web-server for rapid prediction of changes in protein stabilities over a range of temperatures and experimental conditions upon single- or multiple-point substitutions of charged residues. Potential mutants are identified by a charge-shuffling procedure while the stability changes (i.e. an unfolding curve) are predicted employing an ensemble-based statistical-mechanical model. We expect this server to be a simple yet detailed tool for engineering stabilities, identifying electrostatically frustrated residues, generating local stability maps and in constructing fitness landscapes...
October 28, 2017: Bioinformatics
https://www.readbyqxmd.com/read/29090101/plasmablastic-lymphoma-case-report-of-prolonged-survival-of-an-advanced-human-immunodeficiency-patient-and-literature-review
#6
Hind Rafei, Ehab El-Bahesh, Antoine Finianos, Min-Ling L Liu, Geraldine P Schechter
Clinical Practice Points. Plasmablastic lymphoma (PBL) is a rare and highly aggressive variant of diffuse large B cell lymphoma with median survival of advanced stage patients varying between 6 and 15 months in previous reports. We report here a human immunodeficiency virus-infected patient surviving over 12 years following treatment for advanced PBL with EPOCH chemotherapy and intrathecal therapy. This case highlights the potential for improved survival in PBL with intensive chemotherapy. Further, literature review suggests promising prospects utilizing novel targeted therapies to increase the rate of prolonged responses...
2017: Case Reports in Hematology
https://www.readbyqxmd.com/read/29066482/the-effect-of-metformin-on-the-expression-of-gpr109a-nf-%C3%AE%C2%BAb-and-il-1%C3%AE-in-peripheral-blood-leukocytes-from-patients-with-type-2-diabetes-mellitus
#7
Xiaoling Xu, Shaoda Lin, Yongsong Chen, Xitao Li, Shuhua Ma, Yucai Fu, Chiju Wei, Chang Wang, Wencan Xu
OBJECTIVES: Type 2 Diabetes Mellitus (T2DM), which often accompanies dyslipidemia, is considered an inflammatory disease. GPR109A, as a niacin receptor, is up-regulated under high glucose concentration. Activation of GPR109A reduces GSIS and exerts anti-inflammatory effects by regulating NF-κB/IL-1β signaling. Metformin improves hyperglycemia, increases insulin sensitivity and attenuates the activation of the NF-κB pathway in T2DM. We aimed to examine whether metformin plays beneficial effects in T2DM by regulating the GPR109A signaling...
September 2017: Annals of Clinical and Laboratory Science
https://www.readbyqxmd.com/read/29066398/characterization-of-a-teleost-membrane-associated-protein-that-is-involved-in-the-regulation-of-complement-activation-and-bacterial-infection
#8
Mo-Fei Li, Li Sun
In mammals, membrane-associated complement regulatory proteins (MCRP) can protect host cells from the damaging of the activated complement. In teleost, few studies on the function of MCRP have been documented. In the present report, we identified a MCRP (named CsMCRP) from the teleost fish tongue sole Cynoglossus semilaevis and examined its immune function. CsMCRP shares moderate sequence identities with fish DAF-like molecules. CsMCRP was predicted to be a transmembrane protein with three short consensus repeats located in the extracellular region...
October 21, 2017: Developmental and Comparative Immunology
https://www.readbyqxmd.com/read/29059802/problem-based-learning-for-engineering
#9
Dinesh Kumar, Pj Radcliffe
the role of Problem Based Learning (PBL) is relative clear in domains such as medicine but its efficacy in engineering is as yet less certain. To clarify the role of PBL in engineering, a 3 day workshop was conducted for senior Brazilian engineering academics where they were given the theory and then an immersive PBL experience. One major purpose for running this workshop was for them to identify suitable courses where PBL could be considered. During this workshop, they were split in teams and given a diverse range of problems...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/29056610/problem-based-peer-to-peer-global-mental-health-e-learning-between-the-uk-and-somaliland-a-pilot-study
#10
Roberta Murphy, Elliot Clissold, Roxanne C Keynejad
BACKGROUND: WHO's mental health gap action programme intervention guide (mhGAP-IG) is an evidence-based tool aimed at front-line health workers in low-income and middle-income countries (LMICs). Its potential to improve global mental health education, especially through digital technologies, has been little studied. Problem-based learning (PBL) is usually conducted face-to-face, but its remote application could facilitate cross-cultural education. OBJECTIVE: To evaluate PBL, applied to peer-to-peer global mental health e-learning (Aqoon), using mhGAP-IG...
October 22, 2017: Evidence-based Mental Health
https://www.readbyqxmd.com/read/29052312/bleomycin-induced-chromosomal-damage-and-shortening-of-telomeres-in-peripheral-blood-lymphocytes-of-incident-cancer-patients
#11
Michal Kroupa, Zdenka Polivkova, Sivaramakrishna Rachakonda, Michaela Schneiderova, Sona Vodenkova, Tomas Buchler, Katerina Jiraskova, Marketa Urbanova, Ludmila Vodickova, Kari Hemminki, Rajiv Kumar, Pavel Vodicka
Disruption of genomic integrity due to deficient DNA repair capacity and telomere shortening constitute hallmarks of malignant diseases. Incomplete or deficient repair of DNA double-strand breaks (DSB) is manifested by chromosomal aberrations (CAs) and their frequency reflects inter-individual differences of response to exposure to mutagenic compounds. In this study, we investigated chromosomal integrity in peripheral blood lymphocytes (PBL) from newly diagnosed cancer patients, including 47 breast (BC) and 44 colorectal cancer (CRC) patients and 90 matched healthy controls...
October 20, 2017: Genes, Chromosomes & Cancer
https://www.readbyqxmd.com/read/29049210/topical-use-of-tranexamic-acid-can-effectively-decrease-hidden-blood-loss-during-posterior-lumbar-spinal-fusion-surgery-a-retrospective-study
#12
Zhinan Ren, Shugang Li, Lin Sheng, Qianyu Zhuang, Zheng Li, Derong Xu, Xin Chen, Pengxiang Jiang, Xiao Zhang
In spinal fusion surgery, total blood loss (TBL) is composed of visible blood loss from the surgical field and wound drainage, and hidden blood loss (HBL). Until now, no published studies exist reporting the effect of topical use of tranexamic acid (tTXA) on HBL in patients undergoing posterior lumbar spinal fusion surgery. This study aimed to explore the effect of tTXA on HBL during primary posterior lumbar spinal fusion surgery. Between September 2014 and September 2016, 100 adult patients (age > 18 years) with lumbar disc herniation or lumbar spinal stenosis undergoing primary posterior lumbar instrumented spinal fusions at 1 institution were divided into tTXA and control groups...
October 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29042827/use-of-a-problem-based-learning-teaching-model-for-undergraduate-medical-and-nursing-education-a-systematic-review-and-meta-analysis
#13
REVIEW
Mehdi Sayyah, Kiarash Shirbandi, Amal Saki-Malehi, Fakher Rahim
OBJECTIVES: The aim of this systematic review and meta-analysis was to evaluate the problem-based learning (PBL) method as an alternative to conventional educational methods in Iranian undergraduate medical courses. MATERIALS AND METHODS: We systematically searched international datasets banks, including PubMed, Scopus, and Embase, and internal resources of banks, including MagirIran, IranMedex, IranDoc, and Scientific Information Database (SID), using appropriate search terms, such as "PBL", "problem-based learning", "based on problems", "active learning", and" learner centered", to identify PBL studies, and these were combined with other key terms such as "medical", "undergraduate", "Iranian", "Islamic Republic of Iran", "I...
2017: Advances in Medical Education and Practice
https://www.readbyqxmd.com/read/29032293/facilitating-problem-based-learning-among-undergraduate-nursing-students-a-qualitative-systematic-review
#14
REVIEW
Jacqueline Wosinski, Anne E Belcher, Yvan Dürrenberger, Anne-Claude Allin, Coraline Stormacq, Linda Gerson
OBJECTIVES: The purpose of this study was to identify and synthesize the best available evidence on the perspective of undergraduate nursing students on facilitating elements that contribute to their success with PBL. DESIGN: a qualitative systematic review of the literature according to meta-aggregative methodology using the JBI SUMARI system was conducted. DATA SOURCES: Data was collected across CINAHL, Medline, Embase, Eric, Teacher Reference Center and reference lists...
September 8, 2017: Nurse Education Today
https://www.readbyqxmd.com/read/29029989/the-effect-of-demographic-and-disease-variables-on-schneiderian-membrane-thickness-and-appearance
#15
Tuba Talo Yildirim, Güliz Nigar Güncü, Dincer Göksülük, Melek Didem Tözüm, Mehmet Colak, Tolga Fikret Tözüm
OBJECTIVES: The purpose of this study was to evaluate the prevalence of sinus mucosal thickening (MT) and mucosal appearance (MA) in a patient population as detected with cone beam computed tomography (CBCT) and to determine the effects of various disease and demographic factors on MT and MA. STUDY DESIGN: The retrospective study consisted of CBCT images of 1000 maxillary arches in 500 patients. The arches were divided into 3 groups (atrophic, partially atrophic, and nonatrophic) according to the type of the maxillary dental crest...
September 8, 2017: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
https://www.readbyqxmd.com/read/29029457/prognostic-relevance-of-protein-expression-clinical-factors-and-myd88-mutation-in-primary-bone-lymphoma
#16
Yong Xu, Jian Li, Jian Ouyang, Juan Li, Jingyan Xu, Qiguo Zhang, Yonggong Yang, Min Zhou, Jing Wang, Cuiling Zhang, Yueyi Xu, Ping Li, Rongfu Zhou, Bing Chen
Primary bone lymphomas (PBLs) are composed of malignant lymphoid cells presenting in osseous sites, without supra-regional lymph node or extranodal involvement. We systematically characterized the immunophenotype and the myeloid differentiation factor 88 (MYD88)-L265P gene mutation status in PBL. Clinical data from 19 patients with PBL treated at Nanjing Drum Tower Hospital between 2009 and 2015 were analyzed retrospectively. Protein expression patterns were identified immunohistochemically, and MYD88 mutation was assessed using polymerase chain reaction and direct DNA sequencing...
September 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/29019447/survival-of-patients-with-cd20-negative-variants-of-large-b-cell-lymphoma-an-analysis-of-the-national-cancer-data-base
#17
Lindor Qunaj, Jorge J Castillo, Adam J Olszewski
Using records from the National Cancer Data Base, we studied overall survival of CD20-negative variants of diffuse large B-cell lymphoma (DLBCL): primary effusion (PEL, N = 228), plasmablastic (PBL, N = 481), ALK-positive large B-cell (ALK + LBLC, N = 15), and human herpesvirus-8-positive DLBCL (HHV8 + DLBCL, N = 77). Three-year survival was 27% for PEL, 40% for PBL, 34% for ALK + LBCL, and 63% for HHV8 + DLBCL. Compared with unspecified DLBCL, and adjusting for clinical characteristics (including the HIV status), survival was significantly worse for PEL (hazard ratio [HR], 1...
October 11, 2017: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/28993364/durable-complete-remission-with-combination-chemotherapy-and-bortezomib-in-hiv-associated-plasmablastic-lymphoma
#18
Nivedita Arora, Arjun Gupta, Navid Sadeghi
Plasmablastic lymphoma (PBL) is an aggressive form of non-Hodgkin's lymphoma (NHL) classically seen in patients infected with the human immunodeficiency virus, but can also be seen in other immunocompromised states such as transplant recipients, autoimmune diseases and the elderly. PBL is generally associated with a poor prognosis despite chemotherapy. There is evidence supporting the use of bortezomib in combination with standard chemotherapy to achieve durable responses in patients with PBL. We describe a patient with acquired immunodeficiency syndrome who presented with rectal pain and bright red blood per rectum...
October 9, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28974125/prevalence-of-depressive-symptoms-among-medical-students-taught-using-problem-based-learning-versus-traditional-methods
#19
José Aderval Aragão, Marianna Ribeiro de Menezes Freire, Lucas Guimarães Nolasco Farias, Sarah Santana Diniz, Felipe Matheus Sant'anna Aragão, Iapunira Catarina Sant'anna Aragão, Tarcisio Brandão Lima, Francisco Prado Reis
OBJECTIVE: To compare depressive symptoms among medical students taught using problem-based learning (PBL) and the traditional method. MATERIAL AND METHODS: Beck's Depression Inventory was applied to 215 medical students. The prevalence of depression was calculated as the number of individuals with depression divided by the total number in the sample from each course, with 95% confidence intervals. The statistical significance level used was 5% (p ≤ .05). RESULTS: Among the 215 students, 52...
October 3, 2017: International Journal of Psychiatry in Clinical Practice
https://www.readbyqxmd.com/read/28970465/exploring-a-problem-based-learning-approach-in-pharmaceutics
#20
Barbara McKenzie, Alyson Brown
OBJECTIVE: The basis of this study was to explore the impact of the initiation of a Problem-Base Learning (PBL) approach within a second-year pharmaceutics degree on a Master of Pharmacy programme, introduced as a way of improving deep learning and to foster independent learning. DESIGN: A semi-structured interview was used to seek feedback from the students, and feedback from staff was secured though a focus group. A thematic approach was used for the analysis, once data saturation had been reached...
September 20, 2017: Pharmacy (Basel, Switzerland)
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